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Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
AH-23848 | 218901 | 3H-ILOPROST | 0 | Human | Binding | pKi | = | 10000.00 | 5.00 | -10 | 6 | - | PDSP KiDatabase | 477.3 | 11 | 1 | 5 | 5.08 | O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1 | - | |
AH-23848 | 218901 | 3H-ILOPROST | 0 | Human | Binding | pKi | = | 10000.00 | 5.00 | -10 | 6 | - | PDSP KiDatabase | 477.3 | 11 | 1 | 5 | 5.08 | O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1 | - | |
AH6809 | 320 | 3H-ILOPROST | 49 | Human | Binding | pKi | = | 10000.00 | 5.00 | -30 | 10 | - | PDSP KiDatabase | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | - | |
AP-227 | 97263 | None | 0 | Human | Binding | IC50 | = | 150.00 | 6.82 | - | 1 | Displacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets | ChEMBL | 471.2 | 11 | 1 | 4 | 6.61 | CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 | https://dx.doi.org/10.1016/0960-894X(95)00168-S | |
beraprost | 601 | None | 0 | Human | Binding | pKi | = | - | 7.41 | -2 | 5 | Unclassified | Guide to Pharmacology | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)C(O)/C=C/C1C(O)CC2Oc3c(CCCC(=O)O)cccc3C21 | https://pubmed.ncbi.nlm.nih.gov/17545310 | |
beraprost | 601 | None | 0 | Rat | Binding | pKi | = | - | 7.72 | -1 | 5 | Unclassified | Guide to Pharmacology | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)C(O)/C=C/C1C(O)CC2Oc3c(CCCC(=O)O)cccc3C21 | https://pubmed.ncbi.nlm.nih.gov/17545310 | |
beraprost | 220183 | None | 0 | Rat | Binding | pKi | = | 7.72 | 8.11 | -1 | 5 | None | Drug Central | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3O[C@H]2C[C@H]1O | - | |
beraprost | 601 | None | 0 | Mouse | Binding | pKi | = | - | 7.80 | 1 | 5 | Unclassified | Guide to Pharmacology | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)C(O)/C=C/C1C(O)CC2Oc3c(CCCC(=O)O)cccc3C21 | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
BERAPROST | 218536 | 3H-ILOPROST | 0 | Mouse | Binding | pKi | = | 16.00 | 7.80 | 6 | 2 | - | PDSP KiDatabase | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)C(O)C=CC1C(O)CC2Oc3c(CCCC(=O)O)cccc3C21 | - | |
beraprost | 220183 | None | 0 | Mouse | Binding | pKi | = | 7.80 | 8.11 | -1 | 5 | None | Drug Central | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3O[C@H]2C[C@H]1O | - | |
BUTAPROST | 97856 | None | 23 | Human | Binding | IC50 | = | 37.00 | 7.43 | -91 | 9 | Agonist activity at prostanoid IP receptor (unknown origin) by functional assay | ChEMBL | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | https://dx.doi.org/10.1021/jm401431x | |
BUTAPROST | 97856 | 3H-ILOPROST | 23 | Human | Binding | pKi | = | 10000.00 | 5.00 | -91 | 9 | - | PDSP KiDatabase | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | - | |
BUTAPROST | 97856 | 3H-ILOPROST | 23 | Human | Binding | pKi | = | 10000.00 | 5.00 | -91 | 9 | - | PDSP KiDatabase | 408.3 | 13 | 2 | 5 | 4.34 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | - | |
butaprost (free acid form) | 747 | None | 19 | Human | Binding | pKi | None | - | 4.30 | -104 | 9 | Unclassified | Guide to Pharmacology | 394.3 | 13 | 3 | 4 | 4.25 | CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 | https://pubmed.ncbi.nlm.nih.gov/10634944 | |
butaprost (free acid form) | 747 | None | 19 | Human | Binding | IC50 | = | 25.00 | 7.60 | -104 | 9 | Agonist activity at prostanoid IP receptor (unknown origin) by functional assay | ChEMBL | 394.3 | 13 | 3 | 4 | 4.25 | CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 | https://dx.doi.org/10.1021/jm401431x | |
butaprost (free acid form) | 747 | None | 19 | Human | Binding | Ki | = | 870.00 | 6.06 | -104 | 9 | Binding affinity to prostanoid IP receptor (unknown origin) | ChEMBL | 394.3 | 13 | 3 | 4 | 4.25 | CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 | https://dx.doi.org/10.1021/jm401431x | |
BW 245C | 752 | 3H-ILOPROST | 0 | Human | Binding | pKi | = | 10000.00 | 5.00 | -14125 | 9 | - | PDSP KiDatabase | 368.2 | 11 | 3 | 4 | 2.66 | O=C(O)CCCCCCC1C(=O)NC(=O)N1CCC(O)C1CCCCC1 | - | |
carbacyclin | 795 | None | 0 | Human | Binding | pKi | None | - | 6.55 | -19 | 13 | Unclassified | Guide to Pharmacology | 350.2 | 10 | 3 | 3 | 4.07 | CCCCC[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C\CCCC(=O)O)C[C@H]2C[C@H]1O | https://pubmed.ncbi.nlm.nih.gov/10634944 | |
CARBACYCLIN | 218534 | 3H-PGI2 | 0 | Human | Binding | pKi | = | 16.60 | 7.78 | -3 | 14 | - | PDSP KiDatabase | 350.2 | 10 | 3 | 3 | 4.07 | CCCCCC(O)C=CC1C(O)CC2CC(=CCCCC(=O)O)CC21 | - | |
CARBACYCLIN | 218534 | None | 0 | Human | Binding | pKi | = | 7.80 | 8.11 | -3 | 14 | None | Drug Central | 350.2 | 10 | 3 | 3 | 4.07 | CCCCCC(O)C=CC1C(O)CC2CC(=CCCCC(=O)O)CC21 | - |
Showing 1 to 20 of 374 entries
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
AFP-07 | 305 | None | 0 | Human | Functional | pIC50 | = | - | 8.50 | - | 1 | Unclassified | Guide to Pharmacology | 388.2 | 10 | 3 | 4 | 3.65 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@H]2O/C(=C\CCCC(=O)O)C(F)(F)[C@@H]21 | https://pubmed.ncbi.nlm.nih.gov/9112287 | |
BAY-73-1449 | 587 | None | 0 | Human | Functional | pIC50 | < | - | 10.00 | - | 1 | Unclassified | Guide to Pharmacology | 425.2 | 9 | 2 | 5 | 4.83 | O=C(O)[C@H](Cc1ccccc1)Nc1cc(-c2ccc(OCc3ccccc3)cc2)ncn1 | https://pubmed.ncbi.nlm.nih.gov/18603238 | |
beraprost | 220183 | None | 0 | Human | Functional | pIC50 | = | 8.37 | 8.08 | - | 5 | None | Drug Central | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3O[C@H]2C[C@H]1O | - | |
BMY 45778 | 694 | None | 0 | Human | Functional | pIC50 | = | - | 8.00 | - | 1 | Unclassified | Guide to Pharmacology | 438.1 | 7 | 1 | 6 | 5.79 | O=C(O)COc1cccc(-c2ocnc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://pubmed.ncbi.nlm.nih.gov/9156364 | |
CAY10441 | 811 | None | 43 | Human | Functional | pA2 | = | - | 8.60 | 1071 | 3 | Unclassified | Guide to Pharmacology | 309.2 | 5 | 2 | 4 | 3.44 | CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 | https://pubmed.ncbi.nlm.nih.gov/16331286 | |
CAY10441 | 811 | None | 43 | Human | Functional | pA2 | = | - | 8.60 | 1071 | 3 | Unclassified | Guide to Pharmacology | 309.2 | 5 | 2 | 4 | 3.44 | CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 | https://pubmed.ncbi.nlm.nih.gov/21549696 | |
CHEMBL1188479 | 12837 | None | 0 | Human | Functional | IC50 | = | 48.00 | 7.32 | 14 | 2 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 454.2 | 8 | 1 | 5 | 5.81 | O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1188479 | 12837 | None | 0 | Rat | Functional | IC50 | = | 700.00 | 6.16 | -14 | 2 | Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 454.2 | 8 | 1 | 5 | 5.81 | O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL119397 | 13572 | None | 0 | Human | Functional | IC50 | = | 1400.00 | 5.85 | 2 | 2 | Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay | ChEMBL | 445.2 | 10 | 2 | 4 | 6.45 | O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 | https://dx.doi.org/10.1021/jm970343g | |
CHEMBL119550 | 13794 | None | 0 | Human | Functional | IC50 | = | 7500.00 | 5.12 | -91 | 3 | Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay | ChEMBL | 459.2 | 8 | 2 | 3 | 6.57 | CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 | https://dx.doi.org/10.1021/jm970343g | |
CHEMBL1205677 | 14678 | None | 3 | Human | Functional | IC50 | = | 60.00 | 7.22 | 19 | 4 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 465.2 | 8 | 1 | 4 | 6.90 | O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1205677 | 14678 | None | 3 | Rat | Functional | IC50 | = | 1200.00 | 5.92 | -19 | 4 | Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 465.2 | 8 | 1 | 4 | 6.90 | O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1205678 | 14679 | None | 0 | Human | Functional | IC50 | = | 533.00 | 6.27 | - | 1 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 465.2 | 8 | 1 | 4 | 7.04 | O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1206115 | 14706 | None | 0 | Human | Functional | IC50 | = | 114.00 | 6.94 | - | 1 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 467.2 | 8 | 1 | 4 | 6.99 | O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1206120 | 14707 | None | 0 | Human | Functional | IC50 | = | 39.00 | 7.41 | - | 1 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 453.2 | 8 | 1 | 4 | 6.60 | O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1207258 | 14824 | None | 0 | Human | Functional | IC50 | = | 53.00 | 7.28 | - | 1 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 453.2 | 8 | 1 | 4 | 6.60 | O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1207287 | 14829 | None | 0 | Human | Functional | IC50 | = | 930.00 | 6.03 | - | 1 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 461.2 | 8 | 1 | 4 | 6.73 | O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1207438 | 14862 | None | 0 | Human | Functional | IC50 | = | 115.00 | 6.94 | - | 1 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 467.2 | 8 | 1 | 4 | 6.99 | O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL1207781 | 14890 | None | 0 | Human | Functional | IC50 | = | 58.00 | 7.24 | - | 1 | Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation | ChEMBL | 454.2 | 8 | 1 | 5 | 5.81 | O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | https://dx.doi.org/10.1016/j.bmcl.2006.06.076 | |
CHEMBL166351 | 57560 | None | 0 | Human | Functional | Ki | = | 37000.00 | 4.43 | - | 8 | Antagonistic activity at Prostanoid IP receptor in human was determined | ChEMBL | 306.0 | 4 | 1 | 1 | 4.68 | O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 | https://dx.doi.org/10.1016/s0960-894x(01)00056-7 |
Showing 1 to 20 of 283 entries