Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
138107701 194243 46 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
5311181 194243 46 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
CHEMBL494 194243 46 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
DB01088 194243 46 None -4 7 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2022.114154
138107701 194243 46 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 194243 46 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 194243 46 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
DB01088 194243 46 None -1 7 Rat 9.2 pEC50 = 9.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
138 9855 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
149351 9855 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 9855 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 9855 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 9855 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 9855 88 None -16 10 Human 8.7 pEC50 = 8.7 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
2720 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
5820 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
6918140 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
CHEMBL1237119 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
DB00374 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis
ChEMBL 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 10.1016/j.ejmech.2022.114154
118727298 124191 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 124191 0 None -3 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
118727308 124201 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 124201 0 None 1 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235755 160487 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 160487 0 None 81 3 Human 8.0 pEC50 = 8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727301 124194 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 124194 0 None -1 3 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839344 158830 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
CHEMBL3967284 158830 0 None -3311 8 Human 6.0 pEC50 = 6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
137636847 162771 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL4061744 162771 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 554 11 3 7 4.1 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
118727293 124186 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 124186 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727305 124198 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398226 124198 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
127052613 146984 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3804978 146984 0 None -13 6 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727312 124205 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 124205 0 None 3 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727307 124200 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 124200 0 None -1 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727297 124190 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 124190 0 None -5 3 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727296 124189 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 124189 0 None 13 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234782 154050 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 154050 0 None 51 3 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727294 124187 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 124187 0 None -7 3 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
118727306 124199 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 124199 0 None -5 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 124188 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 124188 0 None -5 2 Rat 6.9 pEC50 = 6.9 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235522 149298 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 149298 0 None -53 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 124195 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 124195 0 None -2 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 124202 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 124202 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727296 124189 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398217 124189 0 None -13 2 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccc(F)cc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44236221 154497 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 154497 0 None -151 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
44235044 154363 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3930990 154363 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232565 160751 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 160751 0 None -190 3 Rat 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235044 149641 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 149641 0 None -28 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727311 124204 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 124204 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
126495507 146157 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793167 146157 0 None -154 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 425 5 1 5 5.1 Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727292 124185 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398213 124185 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727313 124206 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 124206 0 None -2 2 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
44235519 154984 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 154984 0 None -23 3 Rat 6.8 pEC50 = 6.8 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44232564 152207 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 152207 0 None 162 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727288 124181 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 124181 0 None -7 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44235291 158710 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 158710 0 None 19 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44233041 152053 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
CHEMBL3912947 152053 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)s1 nan
138107701 194243 46 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 194243 46 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 194243 46 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
DB01088 194243 46 None -4 7 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44219292 119359 38 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3301604 119359 38 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3919269 119359 38 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
DB12462 119359 38 None 54 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44235522 149298 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3890685 149298 0 None 53 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 nan
44234781 149314 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3890828 149314 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233522 149606 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
CHEMBL3893059 149606 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)nc2)CC1 nan
44235044 149641 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3893346 149641 0 None 28 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234027 149707 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3893909 149707 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 418 8 1 6 4.6 Cc1cnc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44235289 149837 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3895137 149837 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232806 149950 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3896069 149950 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(F)c2)CC1 nan
58172125 150022 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3896580 150022 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 nan
44234528 150349 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3899229 150349 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234532 150447 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3900038 150447 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233772 150452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3900091 150452 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 425 9 1 4 4.8 CN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234533 150774 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3902808 150774 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44233523 150788 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
CHEMBL3902855 150788 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 399 8 1 6 3.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cnccn2)CC1 nan
44235040 151372 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3907754 151372 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235291 151923 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3912086 151923 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44232564 152207 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3914174 152207 0 None 162 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 nan
44236219 152219 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
CHEMBL3914231 152219 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 444 9 2 4 4.6 COc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1F nan
44234780 152249 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3914443 152249 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44233776 152253 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3914495 152253 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 428 9 1 6 4.3 COc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233282 152362 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3915367 152362 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(Cl)c2)CC1 nan
44236220 152584 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3917017 152584 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
58172129 152620 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3917222 152620 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 2 3 4.8 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233775 152624 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
CHEMBL3917276 152624 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccnc(F)c2)CC1 nan
44234028 152650 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
CHEMBL3917503 152650 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O nan
44236217 152746 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3918258 152746 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44219292 152866 38 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3919269 152866 38 None 20 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44234029 152997 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3920236 152997 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 488 10 2 5 4.6 O=C(O)CNC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 nan
44232567 153110 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3921158 153110 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44235983 153156 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3921534 153156 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 9 2 3 4.3 CN(C(=O)NC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44234032 153216 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3922000 153216 0 None 22 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44233042 153313 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3922686 153313 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44235289 153447 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3923745 153447 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44233520 153608 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
CHEMBL3924965 153608 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)c1 nan
58172126 153675 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
CHEMBL3925563 153675 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cn2)CC1 nan
44235521 153734 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3926078 153734 0 None 67 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
58172128 153779 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
CHEMBL3926491 153779 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccccc1N(C(=O)OC[C@H]1CC[C@@H](COCC(=O)O)CC1)c1ccccc1 nan
44233280 153793 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
CHEMBL3926604 153793 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(Cl)cc2)CC1 nan
44235984 154042 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
CHEMBL3928658 154042 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccnc2)CC1 nan
44234782 154050 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3928729 154050 0 None 51 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235044 154363 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3930990 154363 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44234284 154472 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
CHEMBL3931899 154472 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cncc(F)c2)CC1 nan
44235290 154633 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
CHEMBL3933131 154633 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 321 7 2 4 3.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)Nc2ccccc2)CC1 nan
44234032 154703 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3933704 154703 0 None 38 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44232808 154782 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3934336 154782 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44234026 154817 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
CHEMBL3934619 154817 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 453 11 1 4 5.5 CCCN(C(=O)OC[C@H]1CC[C@H](COCC(=O)O)CC1)C(c1ccccc1)c1ccccc1 nan
44235519 154984 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3935924 154984 0 None 23 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
58172127 154991 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
CHEMBL3935961 154991 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 1 5 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cn2)CC1 nan
44233038 155119 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
CHEMBL3937089 155119 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 443 8 1 4 5.6 Cc1cc(C)cc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)c1 nan
44233283 155283 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
CHEMBL3938313 155283 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccnc2)CC1 nan
44233777 155327 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3938716 155327 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 412 8 1 5 4.6 Cc1cncc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44232804 155470 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
CHEMBL3939932 155470 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 398 8 1 5 4.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccn2)CC1 nan
44233518 155607 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
CHEMBL3941036 155607 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 459 10 1 5 5.4 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)cc1 nan
44235519 155817 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3942683 155817 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235043 155856 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
CHEMBL3943011 155856 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 464 8 2 3 5.5 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(C(F)(F)F)c2)CC1 nan
44234530 155884 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
CHEMBL3943161 155884 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 8 1 3 4.8 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(c1ccccc1)c1ccccc1 nan
44232568 155971 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3943791 155971 0 None 346 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 nan
44234529 156204 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
CHEMBL3945849 156204 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 nan
44234532 157004 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3952237 157004 0 None 31 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44233774 157015 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3952293 157015 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 441 10 1 5 5.3 CCOc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44233521 157033 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
CHEMBL3952439 157033 0 None 81 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 nan
44235042 157050 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
CHEMBL3952569 157050 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 440 9 2 4 4.8 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c(C)c1 nan
44232569 157187 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
CHEMBL3953739 157187 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(F)c(Cl)c2)CC1 nan
44233279 157448 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
CHEMBL3955699 157448 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 6 3.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cnccn2)CC1 nan
44233039 157675 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3957516 157675 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44232805 157708 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3957760 157708 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 451 8 1 4 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cc(F)cc(F)c2)CC1 nan
44235979 157864 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3959044 157864 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44233040 158026 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
CHEMBL3960203 158026 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 434 8 1 5 4.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)nc2)c2cccc(F)c2)CC1 nan
44233281 158148 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
CHEMBL3961361 158148 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 435 8 1 5 5.4 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(F)cc2)s1 nan
44235756 158197 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
CHEMBL3961761 158197 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 432 8 2 3 4.7 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(F)c2F)CC1 nan
44233773 158205 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
CHEMBL3961809 158205 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 438 9 1 3 4.7 CN(C[C@H]1CC[C@H](COCC(=O)O)CC1)C(=O)N(C)C(c1ccccc1)c1ccccc1 nan
44235041 158538 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
CHEMBL3964788 158538 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 426 9 2 4 4.5 COc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 nan
44235291 158710 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3966307 158710 0 None 19 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
44235039 158716 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
CHEMBL3966331 158716 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1cccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(C)c2)c1 nan
44236216 158933 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
CHEMBL3968156 158933 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 417 8 1 5 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)s1 nan
44234783 159008 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
CHEMBL3968835 159008 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 424 8 2 3 5.1 Cc1ccc(N(C(=O)NC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccc(C)cc2)cc1 nan
44235982 159043 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3969137 159043 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44232566 159222 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
CHEMBL3970829 159222 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(Cl)c2)CC1 nan
44235520 159737 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3975122 159737 0 None 89 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44234528 159764 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3975263 159764 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 396 8 2 3 4.4 O=C(O)COC[C@H]1CC[C@@H](CNC(=O)N(c2ccccc2)c2ccccc2)CC1 nan
44234283 159772 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
CHEMBL3975307 159772 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 466 8 1 5 5.3 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(C(F)(F)F)cn2)CC1 nan
44232807 159882 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
CHEMBL3976286 159882 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(F)c2)CC1 nan
44233519 160016 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
CHEMBL3977415 160016 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(OC(F)(F)F)cc2)CC1 nan
44236218 160033 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
CHEMBL3977559 160033 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 nan
44234779 160058 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
CHEMBL3977761 160058 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 414 8 2 3 4.6 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2ccccc2F)CC1 nan
44235980 160203 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
CHEMBL3979096 160203 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 448 8 2 3 5.2 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2F)CC1 nan
44233043 160393 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
CHEMBL3980758 160393 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 499 9 1 5 5.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2cccc(OC(F)(F)F)c2)CC1 nan
44234782 160468 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
CHEMBL3981383 160468 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@@H](COCC(=O)O)CC2)c2ccccc2)c1 nan
44235981 160484 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
CHEMBL3981484 160484 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(Cl)c2)CC1 nan
44235755 160487 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
CHEMBL3981509 160487 0 None 81 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 nan
44232803 160573 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
CHEMBL3982288 160573 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 447 8 1 4 5.5 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1F nan
44233278 160684 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
CHEMBL3983200 160684 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 416 8 1 5 4.4 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccnc2)c2cccc(F)c2)CC1 nan
44232565 160751 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
CHEMBL3983767 160751 0 None 95 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 nan
44235754 160777 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
CHEMBL3984010 160777 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cc(F)cc(F)c2)CC1 nan
44234278 160799 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
CHEMBL3984207 160799 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 410 9 3 3 4.0 O=C(O)COC[C@H]1CC[C@H](CNC(=O)NC(c2ccccc2)c2ccccc2)CC1 nan
44235753 160958 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
CHEMBL3985726 160958 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 429 8 1 4 5.3 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1F nan
118727297 124190 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398218 124190 0 None 1 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)c(F)c1 10.1016/j.bmcl.2015.01.024
118727311 124204 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 124204 0 None 2 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 124208 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 124208 0 None -10 3 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 10351 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 10351 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 10351 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 10351 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 10351 79 None -7 13 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44234532 157004 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 157004 0 None 31 3 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727285 124178 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 124178 0 None -104 3 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
5852 9395 55 None 1 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 9395 55 None 1 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 9395 55 None 1 6 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44232568 155971 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 155971 0 None 346 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727293 124186 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398214 124186 0 None -2 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3cccc(F)c3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727295 124188 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398216 124188 0 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
58172125 150022 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3896580 150022 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 447 8 2 5 5.2 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(O)cc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44304181 210052 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 210052 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
127052614 147004 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3805176 147004 0 None -645 6 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
118727310 124203 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 124203 0 None 3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727301 124194 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 124194 0 None -1 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727304 124197 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 124197 0 None -3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5283086 210089 24 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
CHEMBL64804 210089 24 None -1258 4 Human 6.6 pEC50 = 6.6 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(01)00359-6
118727314 124207 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 124207 0 None -6 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727286 124179 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398207 124179 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44235291 158710 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 158710 0 None -19 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
44232568 155971 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3943791 155971 0 None -346 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 467 8 1 4 5.8 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2cccc(F)c2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727299 124192 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 124192 0 None -2 3 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 154703 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 154703 0 None -38 3 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
56839536 149947 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
CHEMBL3896035 149947 0 None -16 7 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
44235044 149641 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 149641 0 None 28 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
44235521 153734 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 153734 0 None 67 3 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44235519 154984 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 154984 0 None 23 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727287 124180 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 124180 0 None -18 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232564 152207 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3914174 152207 0 None -446 3 Rat 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(Cl)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727314 124207 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 124207 0 None -1 3 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
1883 9856 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
1916 9856 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
5280360 9856 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
913 9856 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
CHEMBL548 9856 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
DB00917 9856 75 None -54 12 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
118727291 124184 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 124184 0 None -57 3 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
118727290 124183 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 124183 0 None -6 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234532 157004 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 157004 0 None -32 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118727291 124184 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398212 124184 0 None -6 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44303980 174853 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL432522 174853 0 None -1 2 Human 7.4 pEC50 = 7.4 Functional
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptorEffective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor
ChEMBL 408 13 2 5 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1016/s0960-894x(01)00359-6
118727288 124181 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398209 124181 0 None -14 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 480 7 1 5 5.2 Cc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727309 124202 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398230 124202 0 None -2 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3F)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727307 124200 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 124200 0 None 1 3 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44235522 149298 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 149298 0 None 53 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
118727289 124182 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 124182 0 None -8 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 124205 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 124205 0 None -3 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
118727308 124201 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 124201 0 None -1 3 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
44235521 153734 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 153734 0 None -67 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44233521 157033 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952439 157033 0 None 81 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727303 124196 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 124196 0 None -4 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727306 124199 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 124199 0 None -13 3 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44219292 152866 38 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 152866 38 None 20 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
69753740 147000 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
CHEMBL3805134 147000 0 None -12 5 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human IP receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.5b00455
44234782 154050 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 154050 0 None -51 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
44234532 150447 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 150447 0 None -23 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
118352160 146207 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793892 146207 0 None -7079 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 423 5 2 6 4.1 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44236221 154497 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
CHEMBL3932106 154497 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 nan
44236221 154497 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 154497 0 None 97 3 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
118727298 124191 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398219 124191 0 None -16 3 Rat 7.3 pEC50 = 7.3 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1F 10.1016/j.bmcl.2015.01.024
44219292 119359 38 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 119359 38 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 119359 38 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
DB12462 119359 38 None -54 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
118352285 146247 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3794226 146247 0 None -2398 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 406 5 2 5 4.2 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
44235520 159737 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 159737 0 None -89 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234532 150447 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 150447 0 None 23 3 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
56649302 159445 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3972583 159445 0 None -14 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
44235520 154051 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
CHEMBL3928737 154051 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 nan
44219292 152866 38 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 152866 38 None -20 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 153216 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 153216 0 None -22 3 Rat 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727315 124208 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 124208 0 None 4 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
5077 10351 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 10351 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 10351 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 10351 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 10351 79 None -5 13 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
44235520 159737 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 159737 0 None 89 3 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
118727287 124180 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398208 124180 0 None -3 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
118727290 124183 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398211 124183 0 None 1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(Cl)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
118727303 124196 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 124196 0 None -1 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44234531 158196 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
CHEMBL3961754 158196 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at human recombinant prostacyclin receptor expressed in CHO-K1 cells assessed as induction of cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 430 8 2 3 5.1 O=C(O)COC[C@H]1CC[C@H](CNC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 nan
118727300 124193 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 124193 0 None -2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44234032 153216 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 153216 0 None 22 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727300 124193 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398221 124193 0 None -25 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2015.01.024
44235755 160487 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 160487 0 None -81 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727302 124195 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398223 124195 0 None -14 3 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1 10.1016/j.bmcl.2015.01.024
44232565 160751 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 160751 0 None 95 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727316 124209 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 124209 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
118727310 124203 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398231 124203 0 None -3 2 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3cccc(F)c3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029402 146136 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
CHEMBL3793009 146136 0 None -524 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human IP receptor expressed in CHO cells assessed as cAMP level by HTRF assay
ChEMBL 407 5 2 6 3.6 Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl 10.1016/j.bmcl.2016.03.110
118727294 124187 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398215 124187 0 None -5 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2nn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)cc2-c2ccccc2)cc1 10.1016/j.bmcl.2015.01.024
44219292 119359 38 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 119359 38 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 119359 38 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
DB12462 119359 38 None 54 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
44234032 154703 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 154703 0 None 38 3 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727313 124206 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398234 124206 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 514 8 1 6 5.0 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1F 10.1016/j.bmcl.2015.01.024
118727304 124197 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398225 124197 0 None 3 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 500 7 1 5 5.5 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(Cl)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
56839342 155786 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3942394 155786 0 None -85 7 Human 6.1 pEC50 = 6.1 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
118727299 124192 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
CHEMBL3398220 124192 0 None 1 3 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 510 8 1 6 5.2 COc1cccc(-c2cc(=O)n(CC3CCc4c(cccc4OCC(=O)O)C3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2015.01.024
118727289 124182 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398210 124182 0 None -20 3 Rat 6.1 pEC50 = 6.1 Functional
Agonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at rat recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3cccc(F)c3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
44234028 152650 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 152650 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
56839343 151057 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
CHEMBL3904989 151057 0 None -257 6 Human 5.0 pEC50 = 5.0 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
118727285 124178 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398206 124178 0 None -46 3 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assayAgonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1nc(-c3ccccc3)c(-c3ccccc3)cc1=O)C2 10.1016/j.bmcl.2015.01.024
24901445 94021 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 94021 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416266 21472 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206115 21472 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL212943 21472 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44416264 21628 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207438 21628 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL405770 21628 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 467 8 1 4 7.0 O=C(O)COc1cccc(C[C@@H]2CCCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10028418 21444 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 21444 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 21444 3 None -19 2 Rat 5.9 pIC50 = 5.9 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901438 93476 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 93476 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10694649 20339 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
CHEMBL119397 20339 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 445 10 2 4 6.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NC(=O)c1ccc(/N=N/c2ccccc2)cc1 10.1021/jm970343g
10671942 110993 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
CHEMBL309835 110993 0 None -16 3 Human 5.8 pIC50 = 5.8 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 467 9 2 4 5.5 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3ccccc3c2c1 10.1021/jm970343g
16664733 161606 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 161606 0 None 275 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
24901440 93764 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 93764 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901439 93561 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 93561 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901443 93978 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 93978 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10717385 175291 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
CHEMBL435382 175291 0 None -25703 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@@H](NS(=O)(=O)c2ccc3ccccc3c2)[C@H]2CC[C@@H]1C2 10.1021/jm970343g
24901449 160377 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 160377 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901451 161214 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 161214 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
10529683 170423 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
CHEMBL420404 170423 0 None -4 3 Human 5.5 pIC50 = 5.5 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 509 11 2 5 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NS(=O)(=O)c3ccc(/N=N/c4ccccc4)cc3)[C@@H]1C2 10.1021/jm970343g
24901441 152875 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 152875 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 93461 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 93461 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
44416281 21473 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1206120 21473 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL215442 21473 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10553794 170417 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
CHEMBL420398 170417 0 None -14 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 512 10 2 6 5.4 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2oc3cc([N+](=O)[O-])ccc3c2c1 10.1021/jm970343g
24901447 94074 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 94074 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 19605 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 19605 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 19605 0 None 14 2 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10623568 212107 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
CHEMBL79511 212107 0 None -9 3 Human 5.3 pIC50 = 5.3 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 453 10 2 3 5.2 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 10.1021/jm970343g
24901442 93815 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 93815 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44416279 21590 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207258 21590 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL379203 21590 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 453 8 1 4 6.6 O=C(O)COc1cccc(C[C@@H]2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9825740 21445 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205678 21445 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132649 21445 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 7.0 O=C(O)COc1cccc(CC2=C(c3nc(-c4ccccc4)c(-c4ccccc4)o3)CCCC2)c1 10.1016/j.bmcl.2006.06.076
44416294 21656 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207781 21656 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL438092 21656 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
10601359 111076 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
CHEMBL309987 111076 0 None -151 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 497 10 2 5 5.5 COc1cc2c(cc1S(=O)(=O)N[C@@H]1[C@@H]3CC[C@@H](C3)[C@H]1C/C=C\CCCC(=O)O)oc1ccccc12 10.1021/jm970343g
10028418 21444 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 21444 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 21444 3 None 19 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901437 94835 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 94835 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10139047 19605 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 19605 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 19605 0 None -14 2 Rat 6.2 pIC50 = 6.2 Functional
Agonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at rat PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
24901446 161607 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 161607 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10813802 20561 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
CHEMBL119550 20561 0 None -91 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 459 8 2 3 6.6 CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3ccc4oc5ccccc5c4c3)[C@@H]1C2 10.1021/jm970343g
24901448 93717 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 93717 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901444 93979 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 93979 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP productionAntagonist activity at human IP receptor in HEL 92.1.7 cells assessed as inhibition of iloprost-induced cAMP production
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
10502610 170497 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
CHEMBL420507 170497 0 None -13 3 Human 5.1 pIC50 = 5.1 Functional
Inhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assayInhibition of cAMP formation by carbacyclin in Prostaglandin I2 receptor (IP) assay
ChEMBL 427 9 2 3 4.7 O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2ccccc2c1 10.1021/jm970343g
19358473 21595 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1207287 21595 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL386580 21595 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 461 8 1 4 6.7 O=C(O)COc1cccc(Cc2ccccc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
44377464 126863 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
CHEMBL350832 126863 0 None - 0 Human 4.5 pKi = 4.5 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
10402929 64317 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
CHEMBL166351 64317 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid IP receptor in human was determinedAntagonistic activity at Prostanoid IP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
10204312 10121 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 10121 0 None - 1 Human 8.5 pA2 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
1969 7598 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1969 7598 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
9839644 7598 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 7598 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
CHEMBL9540 7598 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 7598 0 None - 1 Human 8.6 pA2 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 21549696
138 9855 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
149351 9855 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 9855 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 9855 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 9855 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 9855 88 None -16 10 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138107701 194243 46 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 194243 46 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 194243 46 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
DB01088 194243 46 None -4 7 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 10626 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
5820 10626 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
6918140 10626 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
CHEMBL1237119 10626 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
DB00374 10626 59 None -5 5 Human 8.1 pEC50 = 8.1 Functional
NoneNone
Drug Central 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O None
138107701 194243 46 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 194243 46 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 194243 46 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
DB01088 194243 46 None -1 7 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF methodAgonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
2720 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
2720 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
5820 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
6918140 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
CHEMBL1237119 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
DB00374 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 10626 59 None -5 5 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 33440084
11743147 7374 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
5851 7374 0 None - 1 Human 10.0 pIC50 < 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology 425 9 2 5 4.8 OC(=O)[C@@H](Nc1ncnc(c1)c1ccc(cc1)OCc1ccccc1)Cc1ccccc1 18603238
1883 9856 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 None -54 12 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
69658829 224476 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
5853 8349 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
73755162 8349 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 443 11 1 3 6.8 OC(=O)CCC/C=C\C[C@@H]1[C@@H]2CC[C@H]([C@H]1/C=N/OC(c1ccccc1)c1ccccc1)C=C2 3026540
127861 7481 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1963 7481 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
CHEMBL125569 7481 0 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 438 7 1 6 5.8 OC(=O)COc1cccc(c1)c1ocnc1c1nc(c(o1)c1ccccc1)c1ccccc1 9156364
1962 7093 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
5311226 7093 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 10 3 4 3.7 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(=C/CCCC(=O)O)/O2)O 9112287
1968 10526 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
5311243 10526 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
CHEMBL2104890 10526 0 None - 1 Human 6.9 pIC50 None 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 9156364
1965 10546 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
73755022 10546 0 None - 1 Human 8.5 pIC50 None 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 12 3 3 4.7 CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC2C1CC(=C2)CCCCC(=O)O)O)C 9156364
1987175 10566 31 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
9283 10566 31 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
CHEMBL1372836 10566 31 None -1 5 Human 6.7 pKB = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 491 7 3 7 3.6 CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F 23914286
10204312 10121 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
10204312 10121 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040
4042 10121 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 19880449
4042 10121 0 None - 1 Human 9.3 pKB = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 21173040


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
9955130 16277 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11211 16277 0 None - 0 Human 8.0 pIC50 = 8 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 9 2 4 5.2 O=C(O)COc1cccc2c1CCCC2CCC(=O)NN(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
138107701 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
5311181 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
CHEMBL494 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
DB01088 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodDisplacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.11.014
138107701 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
5311181 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
CHEMBL494 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
DB01088 194243 46 None -5 15 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsDisplacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2016.03.006
127029421 146098 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3792615 146098 0 None - 0 Human 6.0 pIC50 = 6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 424 10 1 4 3.9 CCCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
86277844 118703 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
CHEMBL3287898 118703 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibition of prostanoid IP receptor (unknown origin)Inhibition of prostanoid IP receptor (unknown origin)
ChEMBL 512 6 2 3 7.5 CCc1ccccc1NC(=O)N1C[C@@H](C)Oc2cc(-c3ccc([C@H]4CC[C@H](CC(=O)O)CC4)cc3)ccc21 10.1021/ml400527n
44235520 159737 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3975122 159737 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)cc2)CC1 10.1021/acs.jmedchem.6b00871
24901449 160377 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
CHEMBL398063 160377 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 349 5 2 4 3.3 CNC(=O)c1ncoc1Cc1ccc(-c2cccc(NC(C)=O)c2)cc1 10.1016/j.bmcl.2006.12.025
24901439 93561 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232156 93561 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 7 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44432434 93461 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231709 93461 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 363 5 1 4 3.6 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
155544367 180153 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
CHEMBL4527708 180153 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assayAntagonist activity at human Gs-coupled PTGIR assessed as inhibition in beraprost-induced beta-arrestin 2 recruitment incubated for 30 mins followed by beraprost- addition and measured after 90 or 180 mins by pathhunter beta-arrestin assay
ChEMBL 508 3 0 4 6.0 CC[C@]12CCCN(C(=O)c3cccc(Br)c3)CCc3c(n(c4ccccc34)C(=O)C1)[C@@H]2OC 10.1021/acs.jmedchem.9b01924
58602756 146209 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793903 146209 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 466 8 1 5 4.3 O=C(O)COc1cccc2c1OCCN2CCN(C(=O)c1ccccc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.03.009
138107701 194243 46 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
5311181 194243 46 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
CHEMBL494 194243 46 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
DB01088 194243 46 None -5 15 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayBinding affinity to PGI2 receptor (unknown origin) by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmc.2013.03.016
127029417 146213 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 146213 0 None - 1 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
138 9855 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
149351 9855 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
1882 9855 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
5280723 9855 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
CHEMBL495 9855 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
DB00770 9855 88 None -165 18 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/0960-894X(95)00168-S
44235522 149298 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3890685 149298 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
11296282 8191 32 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
5822 8191 32 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
CHEMBL565591 8191 32 None - 1 Human 4.8 pIC50 = 4.8 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 590 6 1 5 7.3 Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C 10.1021/jm9005912
9847589 103985 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268477 103985 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 471 11 1 4 6.6 CCC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
10095633 169010 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL416334 169010 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 457 10 1 4 6.2 CC/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
131814 19165 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL118567 19165 11 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 452 12 1 3 7.7 O=C(O)CCCCCCCCn1nc(-c2ccccc2)c(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
10090048 176195 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL442405 176195 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 362 10 1 3 5.6 O=C(O)CCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
44219292 152866 38 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 152866 38 None - 0 Human 6.8 pIC50 = 6.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 194243 46 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 194243 46 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 194243 46 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
DB01088 194243 46 None -5 15 Human 7.8 pIC50 = 7.8 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
44234032 154703 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 154703 0 None 7 6 Human 7.8 pIC50 = 7.8 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
15236833 17791 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11746 17791 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 466 9 1 4 6.0 O=C(O)COc1cccc2c1CCCC2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
44157014 199396 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL521609 199396 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
44235755 160487 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3981509 160487 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(F)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
118727303 124196 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398224 124196 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
23355418 13473 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL10836 13473 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 8 2 4 4.5 O=C(O)COc1cccc2c1CCC(CC(=O)NN(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44267380 16752 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
CHEMBL11480 16752 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 464 9 1 4 5.9 O=C(O)COc1cccc2c1CCC=C2CCn1cc(C(c2ccccc2)c2ccccc2)cn1 10.1016/0960-894X(95)00170-X
127028521 146250 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3794245 146250 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 423 9 1 3 5.1 O=C(O)COc1ccc(CCCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
9823958 16444 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11291 16444 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCCC2CCON=C(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
44267033 13316 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10829 13316 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 485 12 1 4 7.3 CCC/C(CCC1CCCc2c(OCC(=O)O)cccc21)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235044 149641 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3893346 149641 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
118727306 124199 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398227 124199 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44267032 103937 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL268051 103937 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44267058 169998 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL418338 169998 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(C[C@@H]1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235521 153734 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3926078 153734 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 449 8 1 4 5.7 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)c(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44234782 154050 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
CHEMBL3928729 154050 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 5 4.9 COc1cccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)c1 10.1021/acs.jmedchem.6b00871
118727311 124204 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398232 124204 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 484 7 1 5 5.0 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
127029147 146288 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3793541 146288 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
CHEMBL3794662 146288 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 402 8 1 4 3.2 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)C1 10.1016/j.bmcl.2016.03.009
44266708 11554 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
CHEMBL10404 11554 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 320 12 2 3 4.0 CCCCCC(O)/C=C/CCCc1cccc(OCC(=O)O)c1 10.1016/0960-894X(95)00167-R
44267244 169482 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL417069 169482 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 415 8 1 4 4.7 O=C(O)COc1cccc2c1CCC(CON=C(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
44234532 157004 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3952237 157004 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
1892 7534 20 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 7534 20 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 7534 20 None -104 9 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
1883 9856 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
1916 9856 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
5280360 9856 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
913 9856 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
CHEMBL548 9856 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
DB00917 9856 75 None -10000 24 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/jm401431x
138107701 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
5311181 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
CHEMBL494 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
DB01088 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00168-S
138107701 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5311181 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
CHEMBL494 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
DB01088 194243 46 None -5 15 Human 7.6 pIC50 = 7.6 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/0960-894X(95)00167-R
5852 9395 55 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9931891 9395 55 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL239226 9395 55 None 10 4 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727316 124209 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398237 124209 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 427 9 1 4 5.3 O=C(O)COc1cccc2c1CCC=C2CCON=C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2015.01.024
44232565 160751 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3983767 160751 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 433 8 1 4 5.1 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccc(F)cc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
10477568 11650 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10442 11650 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C\CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10477567 13968 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10856 13968 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 426 9 1 2 6.4 O=C(O)COc1cccc2c1CCC(C/C=C/CC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
127028838 146267 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3794451 146267 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 413 7 1 3 5.0 O=C(O)COC1CCC(=CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
127029416 146199 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793824 146199 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 382 8 1 4 2.9 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccccc2)CC1 10.1016/j.bmcl.2016.03.009
118727301 124194 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398222 124194 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 466 7 1 5 4.8 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3ccccc3)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727312 124205 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
CHEMBL3398233 124205 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 8 1 6 4.9 COc1ccc(-c2c(-c3ccccc3)cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c2=O)cc1 10.1016/j.bmcl.2015.01.024
44159772 75167 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916708 75167 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 535 9 1 4 6.8 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccc(Cl)cc1 10.1016/j.bmcl.2011.01.024
24901441 152875 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL391933 152875 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 451 7 2 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H]3C[C@@H]3c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901451 161214 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL399000 161214 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 406 8 2 5 3.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCN(C)C)cc2)c1 10.1016/j.bmcl.2006.12.025
24901448 93717 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232330 93717 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 411 6 2 4 5.1 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)Nc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
10090958 17421 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
CHEMBL117038 17421 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1cc(-c2ccccc2)c(-c2ccccc2)n1 10.1021/jm00080a028
5311035 104579 29 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
CHEMBL271896 104579 29 None -91 9 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at prostanoid IP receptor (unknown origin) by functional assayAgonist activity at prostanoid IP receptor (unknown origin) by functional assay
ChEMBL 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 10.1021/jm401431x
44219292 119359 38 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 119359 38 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 119359 38 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
DB12462 119359 38 None 25 7 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
15290482 16054 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL11088 16054 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 9 1 4 5.8 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44235519 154984 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3935924 154984 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 411 8 1 4 5.2 Cc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.6b00871
15428700 11354 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
CHEMBL10261 11354 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 403 11 1 4 5.3 O=C(O)COc1cccc(CCC/C=N/OC(c2ccccc2)c2ccccc2)c1 10.1016/0960-894X(95)00167-R
9955518 17815 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
CHEMBL11765 17815 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 452 8 1 4 5.3 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)C2 10.1016/0960-894X(95)00170-X
44565193 183639 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL461390 183639 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of radioligand from IP receptorDisplacement of radioligand from IP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
44267245 16906 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL11571 16906 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 444 11 1 3 6.5 O=C(O)COc1cccc2c1CCCC2CCCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901444 93979 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232768 93979 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44236221 154497 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
CHEMBL3932106 154497 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 445 9 1 5 5.0 COc1ccc(N(C(=O)OC[C@H]2CC[C@H](COCC(=O)O)CC2)c2cccc(F)c2)cc1 10.1021/acs.jmedchem.6b00871
127029420 146151 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793117 146151 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 410 9 1 4 3.5 CCc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
127028839 146165 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
CHEMBL3793265 146165 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 416 8 1 4 3.6 O=C(O)COC1CCN(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2016.03.009
44267196 103783 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
CHEMBL266622 103783 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 430 10 1 3 6.2 O=C(O)COc1cccc2c1CCCC2CCCOC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00169-T
24901447 94074 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL233170 94074 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccncc3)cc2)c1 10.1016/j.bmcl.2006.12.025
16664733 161606 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400404 161606 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 483 9 3 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1 10.1016/j.bmcl.2006.12.025
44266736 11889 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10564 11889 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 366 8 2 3 3.8 O=C(O)COc1cccc2c1CCC(C/C=C/C(O)Cc1ccccc1)C2 10.1016/0960-894X(95)00167-R
24901446 161607 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL400405 161607 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3cccnc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901442 93815 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232578 93815 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
15290515 13904 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10853 13904 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 367 8 1 4 4.2 C/C(CC1CCc2c(cccc2OCC(=O)O)C1)=N\OCc1ccccc1 10.1016/0960-894X(95)00168-S
44266758 105186 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL275493 105186 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 350 8 1 2 4.8 O=C(O)COc1cccc2c1CCC(C/C=C/CCc1ccccc1)C2 10.1016/0960-894X(95)00167-R
44234532 150447 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3900038 150447 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 397 8 1 4 4.9 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2ccccc2)CC1 10.1021/acs.jmedchem.6b00871
44235291 158710 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3966307 158710 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(Cl)c2)CC1 10.1021/acs.jmedchem.6b00871
24901437 94835 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234598 94835 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 425 7 2 4 4.8 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44159530 75159 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
CHEMBL1916700 75159 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranesDisplacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
ChEMBL 501 9 1 4 6.2 CCN(Cc1cc(C(F)(F)F)ccc1-c1cc(CC(=O)O)ccc1OC)C(=O)OCc1ccccc1 10.1016/j.bmcl.2011.01.024
11462174 10592 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
9277 10592 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
CHEMBL560993 10592 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
DB11900 10592 90 None - 2 Human 4.2 pIC50 = 4.2 Binding
Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membraneDisplacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
ChEMBL 348 4 1 3 4.3 Fc1ccc2c(c1)c(Cc1ccc3c(n1)cccc3)c(n2CC(=O)O)C 10.1016/j.bmcl.2009.06.085
44627395 203651 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
CHEMBL565992 203651 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 563 7 1 7 5.6 O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 10.1021/jm9005912
44266768 11704 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
CHEMBL10470 11704 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00168-S
44266768 11704 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
CHEMBL10470 11704 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 443 10 1 4 6.1 O=C(O)COc1cccc2c1CCCC2CC/C=N/OC(c1ccccc1)c1ccccc1 10.1016/0960-894X(95)00167-R
5077 10351 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
7552 10351 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
9913767 10351 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
CHEMBL238804 10351 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
DB11362 10351 79 None -8 4 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.6b00871
118727314 124207 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398235 124207 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
118727315 124208 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398236 124208 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 520 7 1 5 5.3 O=C(O)COc1cccc2c1CC[C@@H](Cn1ncc(-c3cccc(F)c3F)c(-c3ccc(F)cc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44190762 183659 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 183659 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of prostanoid IP receptorInhibition of prostanoid IP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
118727308 124201 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
CHEMBL3398229 124201 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 514 8 1 6 5.0 COc1cccc(-c2cnn(CC3CCc4c(cccc4OCC(=O)O)C3)c(=O)c2-c2ccccc2)c1F 10.1016/j.bmcl.2015.01.024
5077 10351 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
7552 10351 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
9913767 10351 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
CHEMBL238804 10351 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
DB11362 10351 79 None -8 4 Human 5.2 pIC50 = 5.2 Binding
Agonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human PGI2 receptor assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 10.1021/acs.jmedchem.0c01093
10320441 12220 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
CHEMBL10742 12220 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsDisplacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00168-S
10320441 12220 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
CHEMBL10742 12220 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 429 9 1 4 5.4 O=C(O)COc1cccc2c1CCC(C/C=N/OC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00167-R
10452166 25741 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
CHEMBL128747 25741 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptorIC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
ChEMBL 376 11 1 3 6.0 O=C(O)CCCCCCCCn1ncc(-c2ccccc2)c1-c1ccccc1 10.1021/jm00080a028
24901440 93764 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232362 93764 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 1 4 5.2 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N(C)CCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901438 93476 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL231746 93476 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 439 8 2 4 4.9 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
127028837 146170 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793336 146170 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 409 8 1 3 4.7 O=C(O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2016.03.009
24901445 94021 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232964 94021 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 440 8 2 5 4.3 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCCc3ccccn3)cc2)c1 10.1016/j.bmcl.2006.12.025
24901436 94787 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL234391 94787 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NCC(C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44266710 12217 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
CHEMBL10740 12217 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 346 10 2 3 4.1 CCCCCC(O)/C=C/CC1CCc2c(cccc2OCC(=O)O)C1 10.1016/0960-894X(95)00167-R
10321522 174410 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
CHEMBL430154 174410 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human plateletsCompound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
ChEMBL 450 8 1 4 5.6 O=C(O)COc1cccc2c1CCC(Cn1cc(C(c3ccccc3)c3ccccc3)cn1)=C2 10.1016/0960-894X(95)00170-X
138107701 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
DB01088 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
15290495 105013 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
CHEMBL274393 105013 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assayCompound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
ChEMBL 416 9 1 3 5.5 O=C(O)COc1cccc2c1CCC(CCOC(c1ccccc1)c1ccccc1)C2 10.1016/0960-894X(95)00169-T
9934864 214325 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
CHEMBL94751 214325 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregationAgonist activity at PGI2 in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/j.ejmech.2016.07.061
9934864 214325 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
CHEMBL94751 214325 12 None - 1 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregationAgonist activity at PGI2 receptor in Homo sapiens (human) platelets assessed as inhibition of ADP-induced aggregation
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1007/s00044-012-0261-1
118727307 124200 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
CHEMBL3398228 124200 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at human IP receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 502 7 1 5 5.1 O=C(O)COc1cccc2c1CCC(Cn1ncc(-c3cccc(F)c3F)c(-c3ccccc3)c1=O)C2 10.1016/j.bmcl.2015.01.024
44627515 203616 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
CHEMBL565799 203616 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation countingDisplacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
ChEMBL 572 6 1 5 7.2 Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 10.1021/jm9005912
138107701 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
DB01088 194243 46 None -5 15 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
127029418 146172 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793345 146172 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Agonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometryAgonist activity at human IP receptor in platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1 min followed by addition of ADP by aggregometry
ChEMBL 412 9 1 5 2.9 COc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
24901443 93978 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
CHEMBL232767 93978 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Displacement of [3H]iloprost from IP receptor in human platelet membraneDisplacement of [3H]iloprost from IP receptor in human platelet membrane
ChEMBL 453 8 2 4 5.4 CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)NC[C@@H](C)c3ccccc3)cc2)c1 10.1016/j.bmcl.2006.12.025
44234032 153216 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3922000 153216 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationAgonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44266775 11647 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
CHEMBL10439 11647 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsProstaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
ChEMBL 360 11 2 3 4.8 CCCCCC(O)/C=C/CCC1CCCc2c(OCC(=O)O)cccc21 10.1016/0960-894X(95)00167-R
138107701 194243 46 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 194243 46 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 194243 46 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
DB01088 194243 46 None 5 15 Rat 9.0 pKi = 9 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
11414893 213836 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9172 213836 4 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 3 2 4 3.5 Cc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11230941 215122 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9936 215122 1 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 3 2 4 2.7 COc1ccc(-c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10185382 71189 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813119 71189 0 None -100 5 Human 6.0 pKi = 6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
1932 9716 5 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
5311228 9716 5 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
CHEMBL3286796 9716 5 None -5888 6 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 410 12 3 3 4.8 C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O 10.1021/jm401431x
9807448 209951 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
CHEMBL64246 209951 0 None -6309 4 Human 5.0 pKi = 5 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 398 11 3 3 4.7 CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 10.1021/jm401431x
11771014 214135 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9367 214135 4 None - 1 Human 5.0 pKi = 5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 5 0 3 4.4 COc1ccc(Sc2ccc(CN3CCCC3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56681885 71193 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813122 71193 0 None -28 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
44402824 77896 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
CHEMBL195456 77896 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 463 7 3 6 3.8 O=C(O)COc1cccc2c1CC[C@](O)(COC(=O)N(c1ccccc1)c1ccccc1)[C@@H]2O 10.1016/j.bmcl.2005.04.047
10277744 71186 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813116 71186 0 None -38 7 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10185103 21465 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL1206056 21465 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
CHEMBL190497 21465 2 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.042
10185103 21465 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL1206056 21465 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
CHEMBL190497 21465 2 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 494 7 1 5 6.7 O=C(O)COc1cccc2c1CCC[C@H]2N1CCC[C@@H]1c1nc(-c2ccccc2)c(-c2ccccc2)o1 10.1016/j.bmcl.2005.04.047
11461588 11041 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10058 11041 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NCCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11402676 215153 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9953 215153 6 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 258 4 2 3 3.1 COc1ccc(Sc2ccc(C(=N)N)cc2)cc1 10.1016/j.bmcl.2003.10.070
10299717 71191 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813120 71191 0 None -37 6 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
10300724 71203 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813275 71203 0 None -47 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
9939791 168697 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
CHEMBL415310 168697 0 None -1071 8 Human 4.9 pKi = 4.9 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
44402710 78734 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
CHEMBL197319 78734 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 431 7 1 4 5.2 O=C(O)COc1cccc2c1CCC(COC(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/j.bmcl.2005.04.047
44304334 208355 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL60555 208355 0 None -707 5 Human 5.9 pKi = 5.9 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
56682059 71595 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819619 71595 0 None -53 2 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.08.065
11269563 148388 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
CHEMBL385126 148388 0 None -12882 5 Human 4.9 pKi = 4.9 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 399 5 1 3 5.2 CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 10.1021/jm0603668
138 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
149351 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
1882 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
5280723 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
CHEMBL495 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
DB00770 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00365-1
138 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
149351 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
1882 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
5280723 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
CHEMBL495 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
DB00770 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00359-6
138 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
149351 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
1882 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
5280723 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
CHEMBL495 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
DB00770 9855 88 None -165 18 Human 6.8 pKi = 6.8 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(01)00364-x
56678560 71207 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813279 71207 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 518 7 1 7 4.7 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
11488860 26063 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
CHEMBL1290413 26063 0 None -36307 8 Human 4.8 pKi = 4.8 Binding
Binding affinity to prostanoid receptor IP receptorBinding affinity to prostanoid receptor IP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
11198334 214510 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9573 214510 0 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 331 4 2 6 1.9 COc1ccc(S(=O)(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11737656 215024 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9873 215024 5 None - 1 Human 6.8 pKi = 6.8 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 283 4 2 5 2.9 COc1ccc(Oc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
56668353 71206 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813278 71206 0 None -2 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 502 6 1 6 5.0 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56665068 71598 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819622 71598 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56665068 71598 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819622 71598 0 None -123 4 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 500 7 2 5 5.1 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
44400189 74263 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL189378 74263 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 449 7 1 3 7.1 O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
57391066 75017 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915864 75017 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 520 7 2 5 5.6 Cc1cc(C(=O)Nc2cc(C3(C(=O)O)CC3)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
56675399 71590 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
CHEMBL1819614 71590 0 None -229 2 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 480 7 2 5 4.8 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cc(CC(=O)O)ccc1Cl 10.1016/j.bmc.2011.08.065
11260449 75005 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915677 75005 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1cc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11237257 74381 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
CHEMBL190288 74381 0 None -446 2 Human 5.7 pKi = 5.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 494 10 2 6 4.3 CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(=O)O)cccc12 10.1021/jm050194z
10116116 71185 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813115 71185 0 None -25 5 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
53358922 71204 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813276 71204 0 None -38 6 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
15947857 162292 7 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
CHEMBL404199 162292 7 None -1778 7 Human 5.7 pKi = 5.7 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
10163305 71196 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813125 71196 0 None 1 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(F)c1 10.1016/j.bmc.2011.06.014
11374965 75968 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL192662 75968 0 None -2 2 Human 6.7 pKi = 6.7 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 5.7 CC(SCCc1c(CCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
56671851 71211 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813283 71211 0 None -48 2 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.1 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9809136 113666 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL314533 113666 0 None -2089 8 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
9895436 113793 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL315391 113793 0 None -1174 7 Human 4.7 pKi = 4.7 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
53358921 71215 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813287 71215 0 None -457 6 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56678561 71208 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813280 71208 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c1C 10.1016/j.bmc.2011.06.014
21877027 215092 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9910 215092 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 281 4 2 4 2.7 COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
10139183 74997 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915669 74997 0 None -1 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 456 6 1 6 4.2 CN1C[C@@H](COc2ccc(C(=O)n3ccc4c(CC(=O)O)cccc43)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11220357 104120 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL269403 104120 5 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 301 5 2 3 3.6 CC/N=C(\N)Nc1ccc(Sc2ccc(OC)cc2)cc1 10.1016/j.bmcl.2003.10.070
11186023 214139 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9368 214139 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 311 4 2 4 4.3 CC(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
53494965 71587 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1819611 71587 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
11236846 75002 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
CHEMBL1915674 75002 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1cc(C)c(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.065
53494965 71587 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
CHEMBL1819611 71587 0 None -85 3 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C 10.1016/j.bmc.2011.08.007
11350967 73961 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187758 73961 0 None 11 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CCCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56661652 71584 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819609 71584 0 None -169 2 Human 5.6 pKi = 5.6 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 466 7 2 5 4.5 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
56664921 71212 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813284 71212 0 None -39 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 455 6 1 5 5.0 Cc1cc(OC[C@@H]2Cc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
9938626 213612 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL90491 213612 0 None -1778 7 Human 4.6 pKi = 4.6 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
56668527 71582 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819607 71582 0 None -4 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 8 1 5 4.3 CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
11282605 74748 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL191175 74748 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 460 12 1 4 6.8 O=C(O)COc1cccc2c(CCCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44219292 119359 38 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 119359 38 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 119359 38 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
DB12462 119359 38 None 25 7 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
138107701 194243 46 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
5311181 194243 46 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
CHEMBL494 194243 46 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
DB01088 194243 46 None -5 15 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/acs.jmedchem.6b00871
44304436 210099 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64854 210099 0 None -8 5 Human 8.5 pKi = 8.5 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 400 14 3 5 3.8 CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56661510 71213 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813285 71213 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 457 6 1 6 4.8 Cc1cc(OCC2Oc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11336395 214559 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9604 214559 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 5 2 5 4.0 CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11255468 214619 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9639 214619 3 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 314 4 2 6 3.1 O=[N+]([O-])c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44266308 214806 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9744 214806 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 295 4 2 5 2.3 COc1ccc(C(=O)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460304 215225 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9998 215225 5 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 284 4 1 4 3.2 COc1ccc(Sc2ccc(C3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
22024188 104136 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
CHEMBL269520 104136 4 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 267 1 2 4 3.4 c1ccc2c(c1)sc1ccc(NC3=NCCN3)cc12 10.1016/j.bmcl.2003.10.070
11254374 214526 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9583 214526 1 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 275 3 2 4 3.5 c1cc(SC2CCCCC2)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
10228100 71188 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813118 71188 0 None -54 5 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
56661509 71205 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
CHEMBL1813277 71205 0 None -83 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 506 6 1 6 4.8 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1F 10.1016/j.bmc.2011.06.014
57391065 75014 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915861 75014 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 528 7 2 5 5.9 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(C)(C)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
57403305 75015 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
CHEMBL1915862 75015 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 522 7 2 5 5.8 Cc1cc(C(=O)Nc2cc(C(C)(C)C(=O)O)ccc2Cl)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.08.065
11260506 74314 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL189694 74314 0 None -19 2 Human 5.5 pKi = 5.5 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 476 11 2 5 6.0 CCC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11352417 75004 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915676 75004 0 None -123 2 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 494 7 2 5 5.1 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)Nc2cc(CC(=O)O)ccc2Cl)c1C 10.1016/j.bmc.2011.08.065
56672019 71588 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819612 71588 0 None -416 4 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 460 7 2 5 4.5 Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1 10.1016/j.bmc.2011.08.007
56675398 71583 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
CHEMBL1819608 71583 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.065
56675398 71583 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
CHEMBL1819608 71583 0 None -204 2 Human 5.4 pKi = 5.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 446 7 2 5 4.2 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)Nc1cccc(CC(=O)O)c1 10.1016/j.bmc.2011.08.007
10116114 132664 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL364841 132664 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10116114 132664 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
CHEMBL364841 132664 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.065
10116114 132664 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
CHEMBL364841 132664 0 None -10 8 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
11278428 214474 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9552 214474 4 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 5 2 5 3.6 CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11208785 214195 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9398 214195 4 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1cccc(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
11461526 214484 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9558 214484 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 325 3 2 4 4.5 CC(C)(C)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460765 105135 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275233 105135 4 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2cccc(NC3=NCCN3)c2)cc1 10.1016/j.bmcl.2003.10.070
11324024 214272 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9442 214272 3 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccccc1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
138107701 194243 46 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
5311181 194243 46 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
CHEMBL494 194243 46 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
DB01088 194243 46 None -5 15 Human 8.3 pKi = 8.3 Binding
Binding affinity to human PGI2 receptor by radioligand displacement assayBinding affinity to human PGI2 receptor by radioligand displacement assay
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.ejmech.2013.01.044
127046072 146614 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3798917 146614 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
CHEMBL3799044 146614 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptorBinding affinity to human IP receptor
ChEMBL 440 8 1 6 2.9 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccc3c(c2)OCO3)cc1 10.1016/j.bmcl.2016.04.043
11597294 172955 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
CHEMBL426387 172955 4 None -478 8 Human 6.4 pKi = 6.4 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
44234028 152650 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
CHEMBL3917503 152650 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 538 11 2 6 4.4 O=C(COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1)NCCS(=O)(=O)O 10.1021/acs.jmedchem.6b00871
11201693 74159 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188758 74159 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10225921 21586 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1207206 21586 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL363350 21586 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 451 8 1 4 6.5 O=C(O)COc1cccc(C[C@@H]2CCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
11316066 74084 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL188384 74084 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10300616 71200 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813272 71200 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 500 7 1 7 4.6 COc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56658143 71579 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819604 71579 0 None -32 6 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 468 8 2 6 3.4 CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
11292620 75967 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL192661 75967 0 None 1 2 Human 5.3 pKi = 5.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 404 8 1 4 5.9 O=C(O)COc1cccc2c(CSC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
10185612 71187 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813117 71187 0 None -1 4 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
11392403 11322 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10241 11322 5 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11739220 213437 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL8935 213437 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.2 FC(F)(F)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11336790 214981 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9846 214981 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 341 5 2 6 3.4 CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11403716 11014 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10044 11014 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 296 4 2 5 2.8 COc1ccc(N(C)c2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244046 11018 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10045 11018 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 317 4 2 4 3.5 Clc1ccc(Sc2ccc(CNC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11460734 215229 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9999 215229 5 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 298 5 1 4 3.4 COc1ccc(Sc2ccc(CC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
44234032 154703 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 154703 0 None -7 6 Rat 7.3 pKi = 7.3 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
44304058 209956 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL64254 209956 0 None -223 5 Human 6.3 pKi = 6.3 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 374 13 3 6 2.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O 10.1016/s0960-894x(01)00364-x
21893828 71216 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813288 71216 0 None -234 2 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2CC1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
56681899 71217 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813289 71217 0 None -97 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 473 6 1 5 5.3 Cc1cc(OC[C@@H]2COc3ccccc32)ccc1C(=O)n1c(C)c(CC(=O)O)c2cc(F)ccc21 10.1016/j.bmc.2011.06.014
57401554 75019 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1915866 75019 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 536 7 2 5 5.7 CN1C[C@@H](COc2ccc(C(=O)Nc3cc(C(F)(F)C(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11294449 75001 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
CHEMBL1915673 75001 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 474 7 2 5 4.8 Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(C)c1C 10.1016/j.bmc.2011.08.065
9874010 213969 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL92539 213969 0 None -3090 8 Human 4.3 pKi = 4.3 Binding
Compound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human IP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
11261579 74373 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190236 74373 0 None -117 2 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 462 10 2 5 5.6 CC(SCCc1c(CO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
10028418 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL1205677 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
CHEMBL132589 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.042
10028418 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL1205677 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
CHEMBL132589 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.047
10028418 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL1205677 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
CHEMBL132589 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2003.09.054
10028418 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL1205677 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL132589 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
10028418 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL1205677 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL132589 21444 3 None 17 3 Human 7.3 pKi = 7.3 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11293771 74443 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL190735 74443 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 446 11 1 4 6.4 O=C(O)COc1cccc2c(CCSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
56664920 71210 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813282 71210 0 None -26 2 Human 6.2 pKi = 6.2 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 471 6 1 6 4.8 Cc1cc(OC[C@@H]2COc3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
11201307 74665 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL191056 74665 0 None -21 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 9 1 4 6.1 CC(SCCc1coc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11750835 74223 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL189063 74223 0 None 5 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.4 O=C(O)COc1cccc2c(CSCCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
11454655 74548 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
CHEMBL190840 74548 0 None -79 2 Human 5.2 pKi = 5.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 490 12 2 5 6.1 CC(SCCc1c(CCCO)oc2c(OCC(=O)O)cccc12)(c1ccccc1)c1ccccc1 10.1021/jm050194z
11519006 109263 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL2373410 109263 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
CHEMBL3040272 109263 0 None 151 6 Human 8.2 pKi = 8.2 Binding
Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptorInhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
ChEMBL 481 8 1 5 6.1 O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2005.04.076
138107701 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
5311181 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
CHEMBL494 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
DB01088 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorAbility to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2005.04.042
138107701 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
5311181 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
CHEMBL494 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
DB01088 194243 46 None -5 15 Human 8.2 pKi = 8.2 Binding
In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorIn vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1016/j.bmcl.2003.09.054
10028418 21444 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1205677 21444 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL132589 21444 3 None 17 3 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 465 8 1 4 6.9 O=C(O)COc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
9955802 75959 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
CHEMBL192613 75959 0 None -112 3 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]iloprost binding to human prostanoid IP receptorInhibition of [3H]iloprost binding to human prostanoid IP receptor
ChEMBL 435 6 1 3 7.1 O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1021/jm050085k
11404217 104894 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL273530 104894 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NC(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11473193 105124 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL275124 105124 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 337 3 2 4 4.5 Clc1cccc(Cl)c1Sc1ccc(NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11381211 214521 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9580 214521 4 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 305 4 2 2 4.2 CC/N=C(\N)Nc1ccc(Sc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2003.10.070
11370857 214640 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9648 214640 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 4 2 5 4.0 COc1ccc(Sc2ccc(NC3=NC(C)(C)CN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11267409 214643 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
CHEMBL9649 214643 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 327 3 2 6 3.0 c1cc(Sc2ccc3c(c2)OCCO3)ccc1NC1=NCCN1 10.1016/j.bmcl.2003.10.070
11174065 215018 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9868 215018 3 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 299 4 2 5 3.2 COc1ccc(Sc2ccccc2NC2=NCCN2)cc1 10.1016/j.bmcl.2003.10.070
11224239 71578 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
CHEMBL1819603 71578 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.065
11224239 71578 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
CHEMBL1819603 71578 0 None -20 4 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 432 7 2 5 3.8 CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 10.1016/j.bmc.2011.08.007
3356 9060 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
4326 9060 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
9867642 9060 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
CHEMBL426559 9060 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
DB11629 9060 73 None -331 8 Human 5.2 pKi = 5.2 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
11166017 73913 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL187544 73913 0 None 3 2 Human 6.2 pKi = 6.2 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 418 9 1 4 6.0 O=C(O)COc1cccc2c(CSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44234032 154703 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3933704 154703 0 None 7 6 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 415 8 1 4 5.0 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 10.1021/acs.jmedchem.6b00871
138107701 194243 46 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
5311181 194243 46 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
CHEMBL494 194243 46 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
DB01088 194243 46 None -5 15 Human 8.1 pKi = 8.1 Binding
Displacement of radiolabeled iloprost from human prostanoid IP receptorDisplacement of radiolabeled iloprost from human prostanoid IP receptor
ChEMBL 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O 10.1021/jm8007618
11743212 23936 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
CHEMBL125588 23936 0 None -234 7 Human 6.2 pKi = 6.2 Binding
Ability to inhibit the binding of human IP receptor to Prostaglandin I2 receptorAbility to inhibit the binding of human IP receptor to Prostaglandin I2 receptor
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
10227894 71194 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813123 71194 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)ccc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
10181606 213130 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
CHEMBL87371 213130 0 None -288 7 Human 5.1 pKi = 5.1 Binding
Inhibitory constant against Prostanoid IP receptorInhibitory constant against Prostanoid IP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
44304388 209931 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL64187 209931 0 None -1513 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O 10.1016/s0960-894x(01)00365-1
11282319 74438 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
CHEMBL190708 74438 0 None -8 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 448 10 2 5 5.5 O=C(O)COc1cccc2c(CCSC(c3ccccc3)c3ccccc3)c(CO)oc12 10.1021/jm050194z
44219292 119359 38 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3301604 119359 38 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
CHEMBL3919269 119359 38 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
DB12462 119359 38 None -25 7 Rat 7.1 pKi = 7.1 Binding
Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting methodDisplacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
ChEMBL 431 8 1 4 5.5 O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/acs.jmedchem.6b00871
10139047 19605 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL1188479 19605 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
CHEMBL439357 19605 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]iloprost from cloned human PGI2 receptorDisplacement of [3H]iloprost from cloned human PGI2 receptor
ChEMBL 454 8 1 5 5.8 O=C(O)COc1cccc(CN2CCC[C@@H]2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 10.1016/j.bmcl.2006.06.076
11318288 74726 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
CHEMBL191118 74726 0 None -5 2 Human 6.1 pKi = 6.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 516 10 2 5 6.2 O=C(O)COc1cccc2c(CCSC(c3ccccc3)(c3ccccc3)C(F)(F)F)c(CO)oc12 10.1021/jm050194z
11186079 10982 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL10024 10982 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 313 4 2 5 3.6 COc1ccc(Sc2ccc(NC3=NCCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11175906 214147 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9371 214147 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 362 5 3 6 2.6 CS(=O)(=O)Nc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11243628 215040 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL9883 215040 4 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 303 3 2 4 3.9 Clc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11391560 174522 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
CHEMBL430286 174522 5 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 269 3 2 4 3.2 c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 10.1016/j.bmcl.2003.10.070
11244380 214591 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
CHEMBL9626 214591 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligandBinding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
ChEMBL 329 5 2 6 3.2 COc1ccc(OC)c(Sc2ccc(NC3=NCCN3)cc2)c1 10.1016/j.bmcl.2003.10.070
5855 8426 7 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
9911469 8426 7 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
CHEMBL196779 8426 7 None 257 4 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]iloprost from human Prostanoid IP receptorDisplacement of [3H]iloprost from human Prostanoid IP receptor
ChEMBL 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2005.04.047
11407826 130424 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
CHEMBL361939 130424 0 None 38 2 Human 7.1 pKi = 7.1 Binding
Inhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membraneInhibition of [3H]APS-314d binding to prostacyclin receptors (IP) of human platelet membrane
ChEMBL 432 10 1 4 6.0 O=C(O)COc1cccc2c(CCSCC(c3ccccc3)c3ccccc3)coc12 10.1021/jm050194z
44326793 21426 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL1205415 21426 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
CHEMBL94694 21426 0 None - 1 Human 7.1 pKi = 7.1 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 398 8 3 4 3.3 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3OC2C[C@H]1O 10.1016/s0960-894x(00)00571-0
13231966 107728 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL294108 107728 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00365-1
1892 7534 20 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
25886893 7534 20 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
CHEMBL1628262 7534 20 None -104 9 Human 6.1 pKi = 6.1 Binding
Binding affinity to prostanoid IP receptor (unknown origin)Binding affinity to prostanoid IP receptor (unknown origin)
ChEMBL 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10.1021/jm401431x
44304181 210052 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
CHEMBL64663 210052 0 None -12 2 Human 6.1 pKi = 6.1 Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.Binding affinity towards human Prostanoid IP receptor in CHO cells.
ChEMBL 394 13 3 4 4.3 CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1 10.1016/s0960-894x(01)00359-6
13231966 107728 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
CHEMBL294108 107728 0 None -1230 5 Human 6.1 pKi = 6.1 Binding
Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cellsEvaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells
ChEMBL 372 13 3 5 3.2 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O 10.1016/s0960-894x(01)00364-x
56675229 71195 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813124 71195 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)c(Cl)c1 10.1016/j.bmc.2011.06.014
10278907 71192 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813121 71192 0 None -20 3 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
44304474 209710 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
CHEMBL62868 209710 0 None -245 5 Human 6.0 pKi = 6.0 Binding
Affinity for human Prostanoid IP receptor expressed in CHO cellsAffinity for human Prostanoid IP receptor expressed in CHO cells
ChEMBL 372 13 3 5 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O 10.1016/s0960-894x(01)00365-1
56681898 71209 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813281 71209 0 None -6 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 516 6 1 6 5.3 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3cc(F)ccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
56678559 71202 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
CHEMBL1813274 71202 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1cc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)cc1OC[C@@H]1CN(C)c2ccccc2O1 10.1016/j.bmc.2011.06.014
9934864 214325 12 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
CHEMBL94751 214325 12 None - 1 Human 7.0 pKi = 7.0 Binding
Tested for inhibition of 3[H]-iloprost binding to human IP receptorTested for inhibition of 3[H]-iloprost binding to human IP receptor
ChEMBL 480 8 1 5 4.7 O=C(O)COc1cccc2c1CC[C@H](Cn1nc(C(c3ccccc3)c3ccccc3)ccc1=O)C2 10.1016/s0960-894x(00)00571-0
10117702 71201 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
CHEMBL1813273 71201 0 None 3 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation countingDisplacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
ChEMBL 498 6 1 6 5.2 Cc1c(OC[C@@H]2CN(C)c3ccccc3O2)ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c1C 10.1016/j.bmc.2011.06.014
127029417 146213 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
CHEMBL3793911 146213 0 None - 1 Human 6.0 pKi = 6 Binding
Binding affinity to human IP receptor by competitive binding assayBinding affinity to human IP receptor by competitive binding assay
ChEMBL 396 8 1 4 3.2 Cc1ccc(N(CCN2CCC(OCC(=O)O)CC2)C(=O)c2ccccc2)cc1 10.1016/j.bmcl.2016.03.009
10501053 8368 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
8314 8368 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
CHEMBL3137314 8368 0 None - 1 Human 7.9 pKd = 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CC[C@@H]([C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1c1cccc(c1O2)CCCC(=O)O)O)C 2665758
1968 10526 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
5311243 10526 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
CHEMBL2104890 10526 0 None - 1 Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 5 3 4 4.0 O[C@@H]1C[C@H]2[C@@H]([C@H]1/C=C/[C@H](C1CCCCC1)O)C/C(=C/c1cccc(c1)C(=O)O)/O2 22480736
1917 7714 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 7714 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 7714 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 7714 0 3H-ILOPROST 1 9 Mouse 8.0 pKi = 8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
119461 7108 72 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
1896 7108 72 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
CHEMBL1317823 7108 72 3H-ILOPROST -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
119304 7539 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1878 7539 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
40481312 7539 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
CHEMBL575504 7539 0 3H-ILOPROST -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1940 8444 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
3417 8444 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
5311100 8444 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
CHEMBL1201379 8444 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
DB11519 8444 41 3H-ILOPROST -4168 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
1551 9066 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 9066 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 9066 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 9066 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 9066 0 3H-ILOPROST -1412 7 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1913 9242 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
5311223 9242 0 3H-ILOPROST -70794 15 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
1817 9320 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1936 9320 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
5282381 9320 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
CHEMBL606 9320 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
DB00929 9320 68 3H-ILOPROST -269 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1881 9853 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1891 9853 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
448457 9853 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL1235252 9853 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB02056 9853 0 3H-ILOPROST -4570 21 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1883 9856 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 9856 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1883 9856 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 3H-ILOPROST -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 3H-PGI2 -10000 24 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 3H-PGI2 -10000 24 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1884 9857 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 9857 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 9857 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 3H-ILOPROST -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 3H-PGI2 -3019 22 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 3H-PGI2 -3019 22 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1980 10434 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1985 10434 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
6437074 10434 0 3H-ILOPROST -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1888 10672 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1974 10672 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311493 10672 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
CHEMBL521784 10672 29 3H-ILOPROST -1000 17 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311035 104579 29 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
CHEMBL271896 104579 29 3H-ILOPROST -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
1973 210262 15 3H-ILOPROST -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 210262 15 3H-ILOPROST -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 210262 15 3H-ILOPROST -3 36 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
134689669 222829 0 3H-ILOPROST -5495 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
91798918 222842 0 3H-ILOPROST -1479 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 400 10 2 6 2.6 COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
67861203 222844 0 3H-ILOPROST -21379 8 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 424 11 4 5 3.2 C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O None
132748 223191 0 3H-ILOPROST -7 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 3 2 4 4.6 C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl None
None 223193 0 3H-ILOPROST -10 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 477 11 1 5 5.1 C1CC(=O)CC1CCC(=CCC(C(=O)O)N2CCOCC2)OCC3=CC=C(C=C3)C4=CC=CC=C4 None
None 223235 0 Functional -19 3 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 223235 0 3H-PGI2 -19 3 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCCC(C=CC1C(C(CC1=O)O)CCCCCCC(=O)O)O None
None 223239 0 3H-PGI2 1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
None 223239 0 3H-PGI2 -1 2 Mouse 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 356 13 4 4 3.3 CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O None
89077401 222823 0 3H-ILOPROST -1 12 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
89077401 222823 0 3H-ILOPROST -1 12 Mouse 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 222824 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 3H-ILOPROST -4 14 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 9855 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
138 9855 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
149351 9855 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
149351 9855 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 9855 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 9855 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 9855 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 9855 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 9855 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 9855 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 9855 88 3H-PGI2 -165 18 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 9855 88 3H-PGI2 -32 18 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 222825 0 3H-ILOPROST 2 3 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 11 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O None
None 222826 0 3H-ILOPROST 6 2 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 398 8 3 4 3.3 CC#CCC(C)C(C=CC1C(CC2C1C3=C(O2)C(=CC=C3)CCCC(=O)O)O)O None
133126726 222824 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
133126726 222824 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 3H-PGI2 -3 14 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 3H-PGI2 -4 14 Mouse 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
1917 7714 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 7714 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 7714 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 7714 0 3H-ILOPROST -1 9 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
None 223192 0 3H-ILOPROST -7079 6 Human 5.7 pKi = 5.7 Binding
NoneNone
PDSP KiDatabase 384 9 3 3 4.3 C1CCC(CC1)C(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O None
133126726 222824 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 3H-ILOPROST -3 14 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
138 9855 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
149351 9855 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 9855 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 9855 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 9855 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 9855 88 3H-ILOPROST -32 18 Mouse 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
None 222827 0 3H-ILOPROST 15 2 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 442 9 1 5 5.1 CC1=C(C2=C(CC1)C(=CC=C2)OCC(=O)O)CCON=C(C3=CC=CC=C3)C4=CN=CC=C4 None
3356 9060 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
4326 9060 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
9867642 9060 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
CHEMBL426559 9060 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
DB11629 9060 73 None -331 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human IP receptor expressed in HEK293 cellsBinding affinity to human IP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
5077 10351 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 10351 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 10351 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 10351 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 10351 79 None -20 4 Rat 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
138 9855 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
149351 9855 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 9855 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 9855 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 9855 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 9855 88 None -32 18 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5077 10351 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
7552 10351 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
9913767 10351 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
CHEMBL238804 10351 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
DB11362 10351 79 None -8 4 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C None
69658829 224476 0 None -1 4 Rat 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
1917 7714 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 7714 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 7714 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 7714 0 None -1 9 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
133126726 222824 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 None -3 14 Human 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
69658829 224476 0 None -1 4 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 398 8 3 4 3.3 CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC3=C(C=CC=C3CCCC(O)=O)[C@H]12 None
None 223238 0 3H-PGI2 1 2 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
None 223238 0 3H-PGI2 -1 2 Mouse 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 354 11 3 4 3.3 CCCCCC(C=CC1C2CC(OC2CC1O)CCCCC(=O)O)O None
1917 7714 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 7714 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 7714 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 7714 0 None 1 9 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
138107701 194243 46 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 194243 46 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 194243 46 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
DB01088 194243 46 None -7 15 Mouse 8.1 pKi = 8.1 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5077 10351 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 10351 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 10351 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 10351 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 10351 79 None -20 4 Rat 5.7 pKi = 5.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5077 10351 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
7552 10351 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9913767 10351 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL238804 10351 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
DB11362 10351 79 None -8 4 Human 6.6 pKi = 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 496 12 1 7 3.9 O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
138 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
138 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
149351 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
149351 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
1882 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
1882 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5280723 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
5280723 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
CHEMBL495 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
CHEMBL495 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
DB00770 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 11454473
DB00770 9855 88 None -165 18 Human 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 17704830
5852 9395 55 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 9395 55 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 9395 55 None -10 4 Rat 6.7 pKi = 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
10204312 10121 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
4042 10121 0 None - 1 Human 6.9 pKi = 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 7 2 4 5.3 Fc1ccc(cc1)CC(C(=O)O)NC(=O)OCc1cc2c(o1)ccc(c2)c1ccc(cc1)F 16331286
10141039 8468 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
5854 8468 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 8 1 4 6.9 OC(=O)COc1cccc(c1)CC1CCCC=C1c1nc(c(o1)c1ccccc1)c1ccccc1 16837197
1967 7388 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 7388 0 None -2 5 Human 7.4 pKi = 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
2720 10626 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5820 10626 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
6918140 10626 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
CHEMBL1237119 10626 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
DB00374 10626 59 None -5 6 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 10 3 4 3.6 CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O 22480736
5852 9395 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
5852 9395 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
9931891 9395 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
9931891 9395 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
CHEMBL239226 9395 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 17545310
CHEMBL239226 9395 55 None 10 4 Human 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 419 11 1 5 4.9 OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C 23850788
1967 7388 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
5282428 7388 0 None -1 5 Rat 7.7 pKi = 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 17545310
1895 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
1895 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
6435378 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
6435378 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
CHEMBL236025 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
CHEMBL236025 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
DB01088 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
DB01088 8788 0 None -1 16 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 16604093
1967 7388 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
5282428 7388 0 None 1 5 Mouse 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 398 8 3 4 3.3 CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)O)O)C 9313928
1917 7714 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
5311044 7714 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
631 7714 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
CHEMBL160629 7714 0 None -1 9 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 10634944
1034 9859 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
1915 9859 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5280427 9859 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5282411 9859 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
CHEMBL1139 9859 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
DB01240 9859 0 None 501 3 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 10 3 4 3.4 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O 372237
5855 8426 7 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
9911469 8426 7 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
CHEMBL196779 8426 7 None 257 4 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 447 7 2 5 4.3 OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 15914004
1969 7598 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
9839644 7598 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
CHEMBL9540 7598 0 None - 1 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 309 5 2 4 3.4 CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C 16331286
1888 10672 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1974 10672 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
5311493 10672 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
CHEMBL521784 10672 29 None -1000 17 Human 4.2 pKi None 4.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1892 7534 20 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
25886893 7534 20 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
CHEMBL1628262 7534 20 None -104 9 Human 4.3 pKi None 4.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 394 13 3 4 4.3 CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 10634944
1893 7582 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
5311242 7582 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
CHEMBL148319 7582 0 None -19 13 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
1893 7582 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
5311242 7582 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
CHEMBL148319 7582 0 None -7 13 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
1964 9703 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
6536812 9703 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
CHEMBL188539 9703 0 None - 1 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 428 9 1 5 4.7 OC(=O)COc1cccc2c1CCC=C2CCO/N=C(/c1cccnc1)\c1ccccc1 9313928
138 9855 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
149351 9855 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1882 9855 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
5280723 9855 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
CHEMBL495 9855 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
DB00770 9855 88 None -32 18 Mouse 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O 9313928
1934 8871 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
5311244 8871 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
CHEMBL4522827 8871 0 None 1 3 Mouse 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 11 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O 9313928
1917 7714 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
5311044 7714 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
631 7714 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
CHEMBL160629 7714 0 None 1 9 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C 9313928
1895 8788 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
6435378 8788 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
CHEMBL236025 8788 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928
DB01088 8788 0 None 1 16 Mouse 8.0 pKi None 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 9313928