Initializing potency table...
Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
11-deoxy-PGE1 | 7 | None | 0 | Rat | Binding | pKi | None | - | 8.50 | -2 | 6 | Unclassified | Guide to Pharmacology | 338.2 | 13 | 2 | 3 | 4.50 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/9537820 | |
11-deoxy-PGE1 | 7 | None | 0 | Mouse | Binding | pKi | = | - | 8.82 | -1 | 6 | Unclassified | Guide to Pharmacology | 338.2 | 13 | 2 | 3 | 4.50 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF1α | 16 | None | 0 | Human | Binding | IC50 | = | 3100.00 | 5.51 | - | 5 | Affinity for Prostanoid EP3 receptor expressed in CHO cell line | ChEMBL | 428.2 | 13 | 4 | 5 | 3.64 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)COc1cccc(Cl)c1 | https://dx.doi.org/10.1021/jm990542v | |
16,16-dimethyl-PGE2 | 24 | None | 0 | Mouse | Binding | pKi | = | - | 8.72 | 8 | 3 | Unclassified | Guide to Pharmacology | 380.3 | 12 | 3 | 4 | 3.89 | CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
17-phenyl-ω-trinor-PGE2 | 26 | None | 0 | Rat | Binding | pKi | = | - | 8.37 | -1 | 7 | Unclassified | Guide to Pharmacology | 386.2 | 11 | 3 | 4 | 3.30 | O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1ccccc1 | https://pubmed.ncbi.nlm.nih.gov/9537820 | |
17-phenyl-ω-trinor-PGE2 | 26 | None | 0 | Mouse | Binding | pKi | = | - | 8.43 | 1 | 7 | Unclassified | Guide to Pharmacology | 386.2 | 11 | 3 | 4 | 3.30 | O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1ccccc1 | https://pubmed.ncbi.nlm.nih.gov/9313928 | |
2-(4'-Methylaminophenyl)Benzothiazole | 220178 | 3H-EP2 | 0 | Human | Binding | pKi | = | 2.00 | 8.70 | 1 | 7 | - | PDSP KiDatabase | 268.1 | 3 | 1 | 5 | 4.75 | CNc1ccc(N=Nc2ccc3ncsc3c2)cc1 | - | |
AH-23848 | 218901 | 3H-PGE2 | 0 | Human | Binding | pKi | = | 4419.00 | 5.35 | -4 | 6 | - | PDSP KiDatabase | 477.3 | 11 | 1 | 5 | 5.08 | O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1 | - | |
AH-23848 | 218901 | 3H-PGE2 | 0 | Human | Binding | pKi | = | 4090.00 | 5.39 | -4 | 6 | - | PDSP KiDatabase | 477.3 | 11 | 1 | 5 | 5.08 | O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1 | - | |
AH13205 | 317 | 3H-PGE2 | 0 | Mouse | Binding | pKi | = | 82.00 | 7.09 | 3 | 3 | - | PDSP KiDatabase | 388.3 | 13 | 2 | 3 | 5.79 | CCCCCC(O)c1ccc(C2CCC(=O)C2CCCCCCC(=O)O)cc1 | - | |
AH13205 | 317 | 3H-PGE2 | 0 | Mouse | Binding | pKi | = | 82.00 | 7.09 | 3 | 3 | - | PDSP KiDatabase | 388.3 | 13 | 2 | 3 | 5.79 | CCCCCC(O)c1ccc(C2CCC(=O)C2CCCCCCC(=O)O)cc1 | - | |
AH6809 | 320 | None | 49 | Human | Binding | pKi | = | - | 5.80 | -4 | 10 | Unclassified | Guide to Pharmacology | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | https://pubmed.ncbi.nlm.nih.gov/10634944 | |
AH6809 | 320 | 3H-PGE2 | 49 | Human | Binding | pKi | = | 1597.00 | 5.80 | -4 | 10 | - | PDSP KiDatabase | 298.1 | 3 | 1 | 4 | 3.43 | CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 | - | |
amisulpride | 400 | 3H-PGE2 | 72 | Human | Binding | pKi | = | 10000.00 | 5.00 | -4365 | 53 | - | PDSP KiDatabase | 369.2 | 7 | 2 | 6 | 1.28 | CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)c(N)cc1OC | - | |
ANANDAMIDE | 218558 | 3H-PGE2 | 0 | Bovine | Binding | pKi | = | 10000.00 | 5.00 | -147 | 6 | - | PDSP KiDatabase | 347.3 | 16 | 2 | 2 | 5.24 | CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO | - | |
aripiprazole | 470 | 3H-PGE2 | 70 | Human | Binding | pKi | = | 10000.00 | 5.00 | -7244 | 60 | - | PDSP KiDatabase | 447.1 | 7 | 1 | 4 | 4.86 | O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1 | - | |
aripiprazole | 470 | 3H-PGE2 | 70 | Human | Binding | pKi | = | 10000.00 | 5.00 | -7244 | 60 | - | PDSP KiDatabase | 447.1 | 7 | 1 | 4 | 4.86 | O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1 | - | |
ASENAPINE | 107587 | 3H-PGE2 | 16 | Human | Binding | pKi | = | 10000.00 | 5.00 | -58884 | 54 | - | PDSP KiDatabase | 285.1 | 0 | 0 | 2 | 4.26 | CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 | - | |
beraprost | 601 | None | 0 | Human | Binding | pKi | = | - | 6.17 | -42 | 5 | Unclassified | Guide to Pharmacology | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)C(O)/C=C/C1C(O)CC2Oc3c(CCCC(=O)O)cccc3C21 | https://pubmed.ncbi.nlm.nih.gov/17545310 | |
beraprost | 220183 | None | 0 | Human | Binding | pKi | = | 6.17 | 8.21 | -1 | 5 | None | Drug Central | 398.2 | 8 | 3 | 4 | 3.29 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3O[C@H]2C[C@H]1O | - |
Showing 1 to 20 of 1,344 entries
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
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Common name |
GPCRdb ID |
Reference ligand |
Vendors | Species | Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI | |