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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

11-deoxy-PGE₁	7	None	0	Rat	Binding	pKi	None	-	8.50	-2	6	Unclassified	Guide to Pharmacology	338.2	13	2	3	4.50	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9537820
11-deoxy-PGE₁	7	None	0	Mouse	Binding	pKi	=	-	8.82	-1	6	Unclassified	Guide to Pharmacology	338.2	13	2	3	4.50	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9313928
13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF_1α	16	None	0	Human	Binding	IC50	=	3100.00	5.51	-	5	Affinity for Prostanoid EP3 receptor expressed in CHO cell line	ChEMBL	428.2	13	4	5	3.64	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)COc1cccc(Cl)c1	https://dx.doi.org/10.1021/jm990542v
16,16-dimethyl-PGE₂	24	None	0	Mouse	Binding	pKi	=	-	8.72	8	3	Unclassified	Guide to Pharmacology	380.3	12	3	4	3.89	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	https://pubmed.ncbi.nlm.nih.gov/9313928
17-phenyl-ω-trinor-PGE₂	26	None	0	Rat	Binding	pKi	=	-	8.37	-1	7	Unclassified	Guide to Pharmacology	386.2	11	3	4	3.30	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1ccccc1	https://pubmed.ncbi.nlm.nih.gov/9537820
17-phenyl-ω-trinor-PGE₂	26	None	0	Mouse	Binding	pKi	=	-	8.43	1	7	Unclassified	Guide to Pharmacology	386.2	11	3	4	3.30	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1ccccc1	https://pubmed.ncbi.nlm.nih.gov/9313928
2-(4'-Methylaminophenyl)Benzothiazole	220178	3H-EP2	0	Human	Binding	pKi	=	2.00	8.70	1	7	-	PDSP KiDatabase	268.1	3	1	5	4.75	CNc1ccc(N=Nc2ccc3ncsc3c2)cc1	-
AH-23848	218901	3H-PGE2	0	Human	Binding	pKi	=	4419.00	5.35	-4	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH-23848	218901	3H-PGE2	0	Human	Binding	pKi	=	4090.00	5.39	-4	6	-	PDSP KiDatabase	477.3	11	1	5	5.08	O=C1CCC(CCC(=CCC(C(=O)O)N2CCOCC2)OCc2ccc(-c3ccccc3)cc2)C1	-
AH13205	317	3H-PGE2	0	Mouse	Binding	pKi	=	82.00	7.09	3	3	-	PDSP KiDatabase	388.3	13	2	3	5.79	CCCCCC(O)c1ccc(C2CCC(=O)C2CCCCCCC(=O)O)cc1	-
AH13205	317	3H-PGE2	0	Mouse	Binding	pKi	=	82.00	7.09	3	3	-	PDSP KiDatabase	388.3	13	2	3	5.79	CCCCCC(O)c1ccc(C2CCC(=O)C2CCCCCCC(=O)O)cc1	-
AH6809	320	None	49	Human	Binding	pKi	=	-	5.80	-4	10	Unclassified	Guide to Pharmacology	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	https://pubmed.ncbi.nlm.nih.gov/10634944
AH6809	320	3H-PGE2	49	Human	Binding	pKi	=	1597.00	5.80	-4	10	-	PDSP KiDatabase	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	-
amisulpride	400	3H-PGE2	72	Human	Binding	pKi	=	10000.00	5.00	-4365	53	-	PDSP KiDatabase	369.2	7	2	6	1.28	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)c(N)cc1OC	-
ANANDAMIDE	218558	3H-PGE2	0	Bovine	Binding	pKi	=	10000.00	5.00	-147	6	-	PDSP KiDatabase	347.3	16	2	2	5.24	CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO	-
aripiprazole	470	3H-PGE2	70	Human	Binding	pKi	=	10000.00	5.00	-7244	60	-	PDSP KiDatabase	447.1	7	1	4	4.86	O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1	-
aripiprazole	470	3H-PGE2	70	Human	Binding	pKi	=	10000.00	5.00	-7244	60	-	PDSP KiDatabase	447.1	7	1	4	4.86	O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1	-
ASENAPINE	107587	3H-PGE2	16	Human	Binding	pKi	=	10000.00	5.00	-58884	54	-	PDSP KiDatabase	285.1	0	0	2	4.26	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	-
beraprost	601	None	0	Human	Binding	pKi	=	-	6.17	-42	5	Unclassified	Guide to Pharmacology	398.2	8	3	4	3.29	CC#CCC(C)C(O)/C=C/C1C(O)CC2Oc3c(CCCC(=O)O)cccc3C21	https://pubmed.ncbi.nlm.nih.gov/17545310
beraprost	220183	None	0	Human	Binding	pKi	=	6.17	8.21	-1	5	None	Drug Central	398.2	8	3	4	3.29	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2c3cccc(CCCC(=O)O)c3O[C@H]2C[C@H]1O	-

Showing 1 to 20 of 1,344 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

AH6809	320	None	49	Human	Functional	Ki	=	1600.00	5.80	-	10	Antagonist activity at EP3 receptor (unknown origin) by functional cAMP assay	ChEMBL	298.1	3	1	4	3.43	CC(C)Oc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	https://dx.doi.org/10.1021/jm401431x
bimatoprost (free acid form)	659	None	34	Human	Functional	EC50	=	8600.00	5.07	-1737	2	Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay	ChEMBL	388.2	11	4	4	3.10	O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1ccccc1	https://dx.doi.org/10.1021/acsmedchemlett.6b00415
CHEMBL1090937	8048	None	0	Mouse	Functional	IC50	=	3.80	8.42	-	3	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	554.2	12	1	7	4.16	CN(CCOc1cc(Cn2cccn2)ccc1CCC(=O)NS(=O)(=O)c1ccc(F)c(F)c1)c1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1090938	8049	None	0	Mouse	Functional	IC50	=	24.00	7.62	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	552.2	11	1	5	5.24	CN(C)Cc1ccc(CCC(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c(OCCc2ccc3ccccc3c2)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1091738	8133	None	0	Mouse	Functional	IC50	=	10.00	8.00	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	587.2	11	1	6	6.11	Cc1ccc(S(=O)(=O)NC(=O)CCc2ccc(Cn3cccn3)cc2OCCc2ccc3ccccc3c2)cc1Cl	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1091739	8134	None	0	Mouse	Functional	IC50	=	7.80	8.11	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	607.1	11	1	6	6.45	O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(Cl)c(Cl)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1091740	8135	None	0	Mouse	Functional	IC50	=	5.50	8.26	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	591.1	11	1	6	5.94	O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(Cl)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1091741	8136	None	0	Mouse	Functional	IC50	=	1.20	8.92	-	3	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	575.2	11	1	6	5.42	O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1091742	8137	None	0	Mouse	Functional	IC50	=	18.00	7.75	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	564.2	11	1	7	5.01	N#Cc1cccc(S(=O)(=O)NC(=O)CCc2ccc(Cn3cccn3)cc2OCCc2ccc3ccccc3c2)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1091743	8138	None	0	Mouse	Functional	IC50	=	1.40	8.85	-	3	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	576.2	11	2	7	4.88	O=C(CCc1ccc(Cn2cccn2)cc1ONCc1cccc2ccccc12)NS(=O)(=O)c1ccc(F)c(F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1091744	8139	None	0	Mouse	Functional	IC50	=	6.40	8.19	-	3	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	610.2	12	1	8	4.11	O=C(CCc1ccc(Cn2cccn2)cc1OCCc1cccc(N2CCOCC2)c1)NS(=O)(=O)c1ccc(F)c(F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1092097	8197	None	0	Mouse	Functional	IC50	=	47.00	7.33	-	2	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	594.2	11	1	6	5.01	O=C(CCc1ccc(CN2CCOCC2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1092266	8227	None	0	Mouse	Functional	IC50	=	140.00	6.85	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	539.2	11	1	6	5.14	O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1092267	8228	None	0	Mouse	Functional	IC50	=	820.00	6.09	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	540.2	10	2	6	4.89	O=C(NCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1092431	8259	None	0	Mouse	Functional	IC50	=	24.00	7.62	-	2	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	626.2	12	1	6	6.63	N#Cc1cccc(OCc2ccc(CCC(=O)NS(=O)(=O)c3ccc(F)c(F)c3)c(OCCc3ccc4ccccc4c3)c2)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1092432	8260	None	0	Mouse	Functional	IC50	=	0.40	9.40	-	3	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	602.2	12	1	6	6.15	O=C(CCc1ccc(COc2cccnc2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1092976	8352	None	0	Mouse	Functional	IC50	=	51.00	7.29	-	2	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	541.1	12	1	7	4.11	O=C(CCc1ccc(Cn2cccn2)cc1OCCOc1ccccc1)NS(=O)(=O)c1ccc(F)c(F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1093537	8428	None	0	Mouse	Functional	IC50	=	190.00	6.72	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	540.2	11	1	7	4.54	O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccccn1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1093819	8464	None	0	Mouse	Functional	IC50	=	110.00	6.96	-	1	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	560.2	11	1	8	4.91	Cc1csc(S(=O)(=O)NC(=O)CCc2ccc(Cn3cccn3)cc2OCCc2ccc3ccccc3c2)n1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034
CHEMBL1093820	8465	None	0	Mouse	Functional	IC50	=	59.00	7.23	-	3	Antagonist activity at mouse EP3 receptor expressed in CHO cells assessed as inhibition of PGE2-induced increase in intracellular calcium level after 1 hr by FDSS in presence of 1% bovine serum albumin	ChEMBL	525.2	11	1	6	4.27	O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccccc1)NS(=O)(=O)c1ccc(F)c(F)c1	https://dx.doi.org/10.1016/j.bmcl.2010.02.034

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Ligand source activities (1 row/activity)