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Ligand source activities (1 row/activity)

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	25174150	15889	0	None	64	2	Human	10.2	pIC50	=	10.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	582	18	2	6	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099326	15889	0	None	64	2	Human	10.2	pIC50	=	10.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	582	18	2	6	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O	10.1021/jm1001919
	25191879	15898	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	599	18	2	5	8.0	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099335	15898	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	599	18	2	5	8.0	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O	10.1021/jm1001919
	25191880	15895	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	587	18	2	6	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099332	15895	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	587	18	2	6	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	25192021	15886	0	None	223	2	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	580	18	2	4	8.5	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099323	15886	0	None	223	2	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	580	18	2	4	8.5	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O	10.1021/jm1001919
	25192023	15303	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	625	18	2	7	7.6	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1094346	15303	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	625	18	2	7	7.6	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	25192174	15894	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	586	18	2	5	8.5	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099331	15894	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	586	18	2	5	8.5	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	132379	118509	19	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	CHEMBL328712	118509	19	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	25192176	15304	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	626	18	2	8	7.0	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1094347	15304	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	626	18	2	8	7.0	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	25192175	15897	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	588	18	2	7	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099334	15897	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	588	18	2	7	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	25192022	10128	7	None	21	2	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	10.1021/jm1001919
	6158	10128	7	None	21	2	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	10.1021/jm1001919
	CHEMBL1098560	10128	7	None	21	2	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	10.1021/jm1001919
	23501721	15893	0	None	316	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	581	18	2	5	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099330	15893	0	None	316	2	Human	9.3	pIC50	=	9.3	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	581	18	2	5	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O	10.1021/jm1001919
	25192325	15896	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	621	18	2	6	8.6	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099333	15896	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	621	18	2	6	8.6	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O	10.1021/jm1001919
	25192326	15802	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	592	18	2	6	8.6	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1098550	15802	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	592	18	2	6	8.6	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O	10.1021/jm1001919
	25192327	15900	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	624	18	2	6	8.2	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099337	15900	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	624	18	2	6	8.2	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	25192468	15306	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	642	18	2	6	8.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1094349	15306	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	642	18	2	6	8.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O	10.1021/jm1001919
	132379	118509	19	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	CHEMBL328712	118509	19	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	25192471	15305	0	None	15	2	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	642	18	2	6	8.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1094348	15305	0	None	15	2	Human	8.9	pIC50	=	8.9	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	642	18	2	6	8.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	10319829	32890	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	417	11	1	3	6.9	CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL135612	32890	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	417	11	1	3	6.9	CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10341135	36161	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	403	10	1	3	6.5	CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL138380	36161	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	403	10	1	3	6.5	CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10047140	34380	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL136960	34380	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	14946858	35934	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	375	9	0	4	5.5	COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL138174	35934	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	375	9	0	4	5.5	COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	6444688	194099	35	None	-	1	Human	6.0	pIC50	=	6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a008
	CHEMBL49302	194099	35	None	-	1	Human	6.0	pIC50	=	6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a008
	10071290	34873	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137303	34873	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	25192022	10128	7	None	21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	10.1021/jm1001919
	6158	10128	7	None	21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	10.1021/jm1001919
	CHEMBL1098560	10128	7	None	21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	10.1021/jm1001919
	6444688	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00100a034
	CHEMBL49302	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00100a034
	10343923	34556	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	453	9	1	5	6.1	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137074	34556	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	453	9	1	5	6.1	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	10477988	34916	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	433	9	1	5	5.8	CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137330	34916	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	433	9	1	5	5.8	CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10364772	34933	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	419	9	1	5	5.4	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137341	34933	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	419	9	1	5	5.4	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	25192471	15305	0	None	15	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	642	18	2	6	8.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1094348	15305	0	None	15	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	642	18	2	6	8.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	6444688	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm960088k
	CHEMBL49302	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm960088k
	46888200	15899	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	637	18	3	4	9.1	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099336	15899	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	637	18	3	4	9.1	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O	10.1021/jm1001919
	10341242	34926	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	405	10	1	4	5.7	COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1	10.1021/jm00101a008
	CHEMBL137336	34926	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	405	10	1	4	5.7	COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1	10.1021/jm00101a008
	6450158	193953	20	None	-	1	Human	6.9	pIC50	=	6.9	Functional	The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1021/jm00064a006
	CHEMBL49210	193953	20	None	-	1	Human	6.9	pIC50	=	6.9	Functional	The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1021/jm00064a006
	46888199	15892	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	696	18	2	8	8.0	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099329	15892	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	696	18	2	8	8.0	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	114999	10311	21	None	-	1	Human	6.9	pIC50	=	6.9	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/0960-894X(95)00135-G
	6156	10311	21	None	-	1	Human	6.9	pIC50	=	6.9	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/0960-894X(95)00135-G
	CHEMBL14823	10311	21	None	-	1	Human	6.9	pIC50	=	6.9	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/0960-894X(95)00135-G
	44382384	66316	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL171666	66316	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	10092630	34594	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	404	9	2	4	5.7	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137104	34594	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	404	9	2	4	5.7	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10475503	34781	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	390	9	2	4	5.3	CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137247	34781	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	390	9	2	4	5.3	CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10023244	32934	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	389	9	1	3	6.1	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL135671	32934	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	389	9	1	3	6.1	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	44357534	33513	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	385	9	0	6	4.7	c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136243	33513	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	385	9	0	6	4.7	c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10406292	35169	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	361	9	1	3	5.4	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137504	35169	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	361	9	1	3	5.4	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	9865985	35446	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	405	9	1	5	5.2	O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137759	35446	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	405	9	1	5	5.2	O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10427789	34713	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	347	8	1	3	5.0	O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137201	34713	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	347	8	1	3	5.0	O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	23501721	15893	0	None	316	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	581	18	2	5	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099330	15893	0	None	316	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	581	18	2	5	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O	10.1021/jm1001919
	9976757	35274	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	375	9	1	3	5.7	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137581	35274	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	375	9	1	3	5.7	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	44382378	65643	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL168854	65643	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	10474602	32751	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	375	10	1	3	5.8	O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL135434	32751	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	375	10	1	3	5.8	O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	46888201	15901	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	654	19	2	7	8.2	COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1	10.1021/jm1001919
	CHEMBL1099338	15901	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	654	19	2	7	8.2	COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1	10.1021/jm1001919
	3368	7956	26	None	-3	2	Mouse	7.5	pIC50	=	7.5	Functional	Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	9867257	7956	26	None	-3	2	Mouse	7.5	pIC50	=	7.5	Functional	Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	CHEMBL51770	7956	26	None	-3	2	Mouse	7.5	pIC50	=	7.5	Functional	Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	10001576	35154	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137494	35154	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10046878	35206	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	405	10	1	4	5.7	COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137531	35206	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	405	10	1	4	5.7	COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	46888196	15888	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	640	20	2	6	8.5	COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1	10.1021/jm1001919
	CHEMBL1099325	15888	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	640	20	2	6	8.5	COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1	10.1021/jm1001919
	44382275	66511	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL172457	66511	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	25192021	15886	0	None	223	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	580	18	2	4	8.5	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099323	15886	0	None	223	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	580	18	2	4	8.5	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O	10.1021/jm1001919
	44382276	127094	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL352814	127094	0	None	-	1	Human	4.4	pIC50	=	4.4	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	9978895	125754	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL342416	125754	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	10021742	16228	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	CHEMBL111825	16228	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	44356239	34615	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor	ChEMBL	361	8	0	2	4.9	CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1	10.1021/jm00100a034
	CHEMBL137121	34615	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor	ChEMBL	361	8	0	2	4.9	CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1	10.1021/jm00100a034
	46888197	15890	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	582	18	2	6	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099327	15890	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	582	18	2	6	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O	10.1021/jm1001919
	46888198	15891	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	668	18	2	8	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099328	15891	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	668	18	2	8	7.9	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	9934323	107029	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00064a006
	CHEMBL288758	107029	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00064a006
	10091738	34576	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	389	9	1	3	6.0	Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137089	34576	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	389	9	1	3	6.0	Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	46888202	15307	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	656	18	2	6	8.4	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1094350	15307	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	656	18	2	6	8.4	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O	10.1021/jm1001919
	44382468	65862	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL169639	65862	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis	ChEMBL	412	5	1	5	5.1	C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	10430674	126116	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	393	9	1	3	5.8	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL344230	126116	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	393	9	1	3	5.8	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O	10.1021/jm00101a008
	25174150	15889	0	None	64	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	582	18	2	6	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099326	15889	0	None	64	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge	ChEMBL	582	18	2	6	7.3	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O	10.1021/jm1001919
	44357546	123531	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	399	9	0	6	5.2	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1	10.1021/jm00101a008
	CHEMBL337563	123531	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	399	9	0	6	5.2	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1	10.1021/jm00101a008
	46888195	15887	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	616	18	2	4	8.7	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O	10.1021/jm1001919
	CHEMBL1099324	15887	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins	ChEMBL	616	18	2	4	8.7	O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O	10.1021/jm1001919
	122023	57569	60	None	1	3	Human	7.1	pIC50	=	7.1	Functional	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1021/jm960088k
	CHEMBL15766	57569	60	None	1	3	Human	7.1	pIC50	=	7.1	Functional	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1021/jm960088k
	CHEMBL45460	57569	60	None	1	3	Human	7.1	pIC50	=	7.1	Functional	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1021/jm960088k
	132379	118509	19	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	CHEMBL328712	118509	19	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	3368	7956	26	None	3	2	Human	8.0	pIC50	=	8.0	Functional	Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	9867257	7956	26	None	3	2	Human	8.0	pIC50	=	8.0	Functional	Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	CHEMBL51770	7956	26	None	3	2	Human	8.0	pIC50	=	8.0	Functional	Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	10022413	34431	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	376	9	2	4	5.0	Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136991	34431	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes	ChEMBL	376	9	2	4	5.0	Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10692884	194944	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs	ChEMBL	409	10	1	3	5.1	CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1	10.1021/jm980540v
	CHEMBL49866	194944	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs	ChEMBL	409	10	1	3	5.1	CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1	10.1021/jm980540v
	60490	214040	106	None	-8	2	Human	8.2	pIC50	=	8.2	Functional	In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils	Drug Central	236	2	2	3	2.7	CC(c1cc2ccccc2s1)N(O)C(N)=O	None
	CHEMBL93	214040	106	None	-8	2	Human	8.2	pIC50	=	8.2	Functional	In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils	Drug Central	236	2	2	3	2.7	CC(c1cc2ccccc2s1)N(O)C(N)=O	None
	71398	113216	44	None	3	14	Human	8.2	pIC50	=	8.2	Functional	The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN	Drug Central	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	None
	CHEMBL313972	113216	44	None	3	14	Human	8.2	pIC50	=	8.2	Functional	The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN	Drug Central	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	None
	6157	9708	20	None	-	1	Human	5.8	pIC50	=	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	1332129
	6438358	9708	20	None	-	1	Human	5.8	pIC50	=	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	1332129
	CHEMBL422420	9708	20	None	-	1	Human	5.8	pIC50	=	5.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	1332129
	114999	10311	21	None	-	1	Human	6.1	pIC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	7786309
	6156	10311	21	None	-	1	Human	6.1	pIC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	7786309
	CHEMBL14823	10311	21	None	-	1	Human	6.1	pIC50	=	6.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	7786309
	3368	7956	26	None	3	2	Human	8.1	pIC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	7714764
	9867257	7956	26	None	3	2	Human	8.1	pIC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	7714764
	CHEMBL51770	7956	26	None	3	2	Human	8.1	pIC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	7714764
	25192022	10128	7	None	21	2	Human	8.1	pIC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	20214997
	6158	10128	7	None	21	2	Human	8.1	pIC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	20214997
	CHEMBL1098560	10128	7	None	21	2	Human	8.1	pIC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	630	18	2	7	8.3	OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O	20214997
	177941	8369	50	None	-	1	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	2948	8369	50	None	-	1	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	CHEMBL329123	8369	50	None	-	1	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	DB12850	8369	50	None	-	1	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	6154	7421	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	11259574
	6154	7421	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	17170051
	9956189	7421	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	11259574
	9956189	7421	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	17170051
	6155	7959	0	None	1318	2	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393
	9823886	7959	0	None	1318	2	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393
	CHEMBL301829	7959	0	None	1318	2	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393
	DB13053	7959	0	None	1318	2	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44379678	171701	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	527	14	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL422388	171701	0	None	-	0	Human	10.0	pIC50	=	10	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	527	14	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	44379453	64859	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	513	13	1	6	4.9	CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL167350	64859	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	513	13	1	6	4.9	CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	15817161	64909	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	499	13	2	6	4.6	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL167804	64909	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	499	13	2	6	4.6	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	9865985	35446	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	405	9	1	5	5.2	O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137759	35446	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	405	9	1	5	5.2	O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1	10.1021/jm00101a008
	114999	10311	21	None	-	1	Human	9.0	pIC50	=	9	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/S0960-894X(01)80853-2
	6156	10311	21	None	-	1	Human	9.0	pIC50	=	9	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/S0960-894X(01)80853-2
	CHEMBL14823	10311	21	None	-	1	Human	9.0	pIC50	=	9	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/S0960-894X(01)80853-2
	204058	170238	8	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2	10.1021/jm960088k
	CHEMBL419948	170238	8	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2	10.1021/jm960088k
	196905	118408	8	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2	10.1021/jm960088k
	CHEMBL328492	118408	8	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2	10.1021/jm960088k
	2487	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	5280492	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL65061	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	DB12961	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	6444688	194099	35	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00064a006
	CHEMBL49302	194099	35	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00064a006
	2487	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00172a020
	5280492	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00172a020
	CHEMBL65061	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00172a020
	DB12961	9147	36	None	31	2	Human	8.7	pIC50	=	8.7	Binding	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00172a020
	11799000	23940	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane	ChEMBL	482	9	1	4	5.1	CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1	10.1021/jm950699x
	CHEMBL125611	23940	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane	ChEMBL	482	9	1	4	5.1	CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1	10.1021/jm950699x
	10385899	34180	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	393	9	1	4	5.6	COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	CHEMBL136805	34180	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	393	9	1	4	5.6	COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	9999755	33345	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL136094	33345	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1	10.1021/jm00101a008
	44357534	33513	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	385	9	0	6	4.7	c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136243	33513	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	385	9	0	6	4.7	c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10071290	34873	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137303	34873	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	196905	118408	8	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL328492	118408	8	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	11756030	65534	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	509	13	1	7	5.9	CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL168658	65534	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	509	13	1	7	5.9	CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	14946858	35934	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	375	9	0	4	5.5	COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL138174	35934	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	375	9	0	4	5.5	COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10407251	125859	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	377	8	1	3	5.9	Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	CHEMBL342688	125859	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	377	8	1	3	5.9	Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	15666577	15973	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M	ChEMBL	330	11	1	2	5.5	O=C(O)CCCCCCc1ccsc1CCCc1ccccc1	10.1021/jm00095a011
	CHEMBL110402	15973	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M	ChEMBL	330	11	1	2	5.5	O=C(O)CCCCCCc1ccsc1CCCc1ccccc1	10.1021/jm00095a011
	15666579	12399	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	364	11	1	2	6.2	O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1	10.1021/jm00095a011
	CHEMBL107760	12399	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	364	11	1	2	6.2	O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1	10.1021/jm00095a011
	15666578	14676	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	364	11	1	2	6.2	O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1	10.1021/jm00095a011
	CHEMBL109015	14676	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	364	11	1	2	6.2	O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1	10.1021/jm00095a011
	15666603	14910	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	330	11	1	2	5.5	O=C(O)CCCCCCc1sccc1CCCc1ccccc1	10.1021/jm00095a011
	CHEMBL109176	14910	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	330	11	1	2	5.5	O=C(O)CCCCCCc1sccc1CCCc1ccccc1	10.1021/jm00095a011
	15666621	16014	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	406	12	1	2	7.2	O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1	10.1021/jm00095a011
	CHEMBL110707	16014	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	406	12	1	2	7.2	O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1	10.1021/jm00095a011
	44315785	21423	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	326	11	3	3	4.1	CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1	10.1016/0960-894X(96)00424-6
	CHEMBL1205307	21423	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	326	11	3	3	4.1	CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1	10.1016/0960-894X(96)00424-6
	CHEMBL80541	21423	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	326	11	3	3	4.1	CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1	10.1016/0960-894X(96)00424-6
	11741184	34935	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	391	10	1	4	5.4	COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1	10.1021/jm00101a008
	CHEMBL137342	34935	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	391	10	1	4	5.4	COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1	10.1021/jm00101a008
	15666575	11960	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	316	10	1	2	5.1	O=C(O)CCCCCCc1csc(CCc2ccccc2)c1	10.1021/jm00095a011
	CHEMBL106055	11960	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	316	10	1	2	5.1	O=C(O)CCCCCCc1csc(CCc2ccccc2)c1	10.1021/jm00095a011
	15666597	116415	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	302	9	1	2	4.9	O=C(O)CCCCCCc1csc(Cc2ccccc2)c1	10.1021/jm00095a011
	CHEMBL322290	116415	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	302	9	1	2	4.9	O=C(O)CCCCCCc1csc(Cc2ccccc2)c1	10.1021/jm00095a011
	135531245	212043	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	398	10	2	7	3.8	CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1	10.1021/jm00041a021
	CHEMBL78966	212043	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	398	10	2	7	3.8	CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1	10.1021/jm00041a021
	10046878	35206	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	405	10	1	4	5.7	COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137531	35206	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	405	10	1	4	5.7	COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	135503765	211992	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	396	10	3	5	3.8	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1	10.1021/jm00041a021
	CHEMBL78605	211992	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	396	10	3	5	3.8	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1	10.1021/jm00041a021
	15666618	16026	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	344	11	1	2	5.7	CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	CHEMBL110767	16026	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	344	11	1	2	5.7	CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	10024190	32745	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	404	10	1	4	5.5	CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL135431	32745	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	404	10	1	4	5.5	CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10052488	65825	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	523	13	1	7	6.2	CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL169446	65825	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	523	13	1	7	6.2	CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	10069417	171687	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL422282	171687	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	18373405	38471	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	525	7	1	3	7.3	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL140539	38471	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	525	7	1	3	7.3	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12	10.1016/j.bmcl.2003.08.070
	9985159	65900	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	555	14	1	8	6.4	CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL169835	65900	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	555	14	1	8	6.4	CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	44385218	66445	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	343	5	2	2	4.7	O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1	10.1016/S0960-894X(97)00134-0
	CHEMBL172201	66445	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	343	5	2	2	4.7	O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1	10.1016/S0960-894X(97)00134-0
	44385131	136277	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	373	6	2	3	4.7	COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL367291	136277	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	373	6	2	3	4.7	COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	6444688	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00046a017
	CHEMBL49302	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00046a017
	18963028	21394	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	376	11	2	6	4.2	CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205053	21394	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	376	11	2	6	4.2	CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL47716	21394	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	376	11	2	6	4.2	CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	10343923	34556	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	453	9	1	5	6.1	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137074	34556	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	453	9	1	5	6.1	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	135401173	111556	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	396	10	3	5	3.8	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O	10.1021/jm00041a021
	CHEMBL310870	111556	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	396	10	3	5	3.8	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O	10.1021/jm00041a021
	6444688	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00070a015
	CHEMBL49302	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00070a015
	10053662	66434	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	565	15	1	7	7.1	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2	10.1021/jm00006a002
	CHEMBL172168	66434	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	565	15	1	7	7.1	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2	10.1021/jm00006a002
	44337707	116519	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	434	12	1	2	7.8	CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	CHEMBL322985	116519	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	434	12	1	2	7.8	CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	9980059	35132	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1	10.1021/jm00101a008
	CHEMBL137480	35132	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1	10.1021/jm00101a008
	44385159	68125	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.0	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1	10.1016/S0960-894X(97)00134-0
	CHEMBL176747	68125	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.0	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1	10.1016/S0960-894X(97)00134-0
	6444688	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	CHEMBL49302	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	10091738	34576	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	389	9	1	3	6.0	Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137089	34576	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	389	9	1	3	6.0	Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	6444688	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00064a006
	CHEMBL49302	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00064a006
	6444688	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00172a020
	CHEMBL49302	194099	35	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00172a020
	6435820	171795	6	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00070a015
	CHEMBL422598	171795	6	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00070a015
	204058	170238	8	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL419948	170238	8	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	9805394	64357	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	485	13	2	6	4.3	CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL166699	64357	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	485	13	2	6	4.3	CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	10385899	34180	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	393	9	1	4	5.6	COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	CHEMBL136805	34180	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	393	9	1	4	5.6	COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	10474602	32751	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	375	10	1	3	5.8	O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL135434	32751	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	375	10	1	3	5.8	O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10069416	35158	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL137497	35158	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	10341135	36161	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	403	10	1	3	6.5	CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL138380	36161	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	403	10	1	3	6.5	CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	44381856	175335	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	509	13	1	7	6.1	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O	10.1021/jm00006a002
	CHEMBL435665	175335	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	509	13	1	7	6.1	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O	10.1021/jm00006a002
	9930128	67192	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.1	COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL175073	67192	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.1	COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	11726048	34371	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	360	9	1	3	4.8	NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL136953	34371	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	360	9	1	3	4.8	NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10071290	34873	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137303	34873	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	429	9	1	3	6.5	O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10318241	35121	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	390	10	2	4	5.5	CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137472	35121	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	390	10	2	4	5.5	CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10250881	31842	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	408	9	1	5	5.5	CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL134698	31842	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	408	9	1	5	5.5	CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	10390056	123327	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	472	10	2	4	5.9	O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL336303	123327	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	472	10	2	4	5.9	O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10451768	34669	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	369	8	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1	10.1021/jm00101a007
	CHEMBL137168	34669	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	369	8	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1	10.1021/jm00101a007
	15666613	16015	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	344	11	1	2	5.8	Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1	10.1021/jm00095a011
	CHEMBL110708	16015	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	344	11	1	2	5.8	Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1	10.1021/jm00095a011
	44385199	66417	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	375	7	2	3	4.6	COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL172091	66417	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	375	7	2	3	4.6	COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	20704716	191504	0	None	-	1	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	488	5	1	9	2.4	CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O	10.1021/np50100a005
	CHEMBL485054	191504	0	None	-	1	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	488	5	1	9	2.4	CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O	10.1021/np50100a005
	11549986	162986	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	1542	48	11	26	1.8	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1	10.1021/jm050383h
	CHEMBL406432	162986	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	1542	48	11	26	1.8	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1	10.1021/jm050383h
	44386172	172569	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	397	6	2	5	4.2	COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL424779	172569	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	397	6	2	5	4.2	COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	11726048	34371	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	360	9	1	3	4.8	NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL136953	34371	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	360	9	1	3	4.8	NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	44359651	125961	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	481	7	1	3	7.2	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL343124	125961	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	481	7	1	3	7.2	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12	10.1016/j.bmcl.2003.08.070
	6441619	213561	18	None	-	1	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960248s
	CHEMBL90214	213561	18	None	-	1	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960248s
	15718079	108214	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O	10.1021/jm00064a006
	CHEMBL297501	108214	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O	10.1021/jm00064a006
	10430674	126116	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	393	9	1	3	5.8	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL344230	126116	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	393	9	1	3	5.8	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O	10.1021/jm00101a008
	10315808	33722	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	349	9	1	3	5.3	O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1	10.1021/jm00101a007
	CHEMBL136433	33722	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	349	9	1	3	5.3	O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1	10.1021/jm00101a007
	10248148	122773	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	363	8	1	3	5.6	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL335525	122773	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	363	8	1	3	5.6	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	15839736	21412	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	476	9	2	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	10.1016/S0960-894X(01)80999-9
	CHEMBL1205143	21412	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	476	9	2	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	10.1016/S0960-894X(01)80999-9
	CHEMBL58534	21412	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	476	9	2	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	10.1016/S0960-894X(01)80999-9
	44385258	67142	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	7	2	3	5.1	CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL174638	67142	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	7	2	3	5.1	CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	6444688	194099	35	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a007
	CHEMBL49302	194099	35	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a007
	10022413	34431	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	376	9	2	4	5.0	Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136991	34431	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	376	9	2	4	5.0	Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10343923	34556	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	453	9	1	5	6.1	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137074	34556	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	453	9	1	5	6.1	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	10341242	34926	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	405	10	1	4	5.7	COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1	10.1021/jm00101a008
	CHEMBL137336	34926	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	405	10	1	4	5.7	COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1	10.1021/jm00101a008
	6444688	194099	35	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a008
	CHEMBL49302	194099	35	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a008
	9805394	64357	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	485	13	2	6	4.3	CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL166699	64357	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	485	13	2	6	4.3	CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	18963032	107869	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	444	11	2	6	4.5	CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	CHEMBL294987	107869	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	444	11	2	6	4.5	CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	114999	10311	21	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm960088k
	6156	10311	21	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm960088k
	CHEMBL14823	10311	21	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm960088k
	10477988	34916	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	433	9	1	5	5.8	CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137330	34916	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	433	9	1	5	5.8	CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	44357546	123531	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	399	9	0	6	5.2	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1	10.1021/jm00101a008
	CHEMBL337563	123531	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	399	9	0	6	5.2	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1	10.1021/jm00101a008
	178581	147032	2	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C	ChEMBL	413	9	1	5	5.5	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1	10.1021/jm050383h
	CHEMBL380555	147032	2	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C	ChEMBL	413	9	1	5	5.5	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1	10.1021/jm050383h
	15666615	15949	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	372	11	1	2	6.4	Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1	10.1021/jm00095a011
	CHEMBL110243	15949	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	372	11	1	2	6.4	Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1	10.1021/jm00095a011
	10386030	126049	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	395	9	1	3	6.1	O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL343710	126049	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	395	9	1	3	6.1	O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1	10.1021/jm00101a008
	44379592	63932	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	387	10	3	4	4.7	[N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1	10.1016/s0960-894x(00)00103-7
	CHEMBL164721	63932	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	387	10	3	4	4.7	[N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1	10.1016/s0960-894x(00)00103-7
	44379573	64874	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	414	10	2	4	4.7	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1	10.1016/s0960-894x(00)00103-7
	CHEMBL167465	64874	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	414	10	2	4	4.7	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1	10.1016/s0960-894x(00)00103-7
	10021622	35373	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	363	10	1	3	5.7	O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1	10.1021/jm00101a007
	CHEMBL137676	35373	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	363	10	1	3	5.7	O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1	10.1021/jm00101a007
	10430946	122270	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL335142	122270	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O	10.1021/jm00101a007
	15718082	193952	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O	10.1021/jm00064a006
	CHEMBL49209	193952	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O	10.1021/jm00064a006
	195214	190618	19	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	454	16	2	4	6.2	CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1021/jm00064a006
	CHEMBL48068	190618	19	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	454	16	2	4	6.2	CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1021/jm00064a006
	443292	11797	17	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils	ChEMBL	299	3	2	5	3.6	CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1	10.1021/jm00045a011
	CHEMBL105139	11797	17	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils	ChEMBL	299	3	2	5	3.6	CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1	10.1021/jm00045a011
	9934500	172380	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	472	7	1	4	6.4	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL424290	172380	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	472	7	1	4	6.4	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12	10.1016/j.bmcl.2003.08.070
	10319829	32890	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	417	11	1	3	6.9	CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL135612	32890	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	417	11	1	3	6.9	CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10387303	34373	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	418	11	2	4	6.3	CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136955	34373	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	418	11	2	4	6.3	CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	15839732	52461	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	444	13	2	6	4.8	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O	10.1016/S0960-894X(00)80304-2
	CHEMBL15299	52461	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	444	13	2	6	4.8	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O	10.1016/S0960-894X(00)80304-2
	44404447	175537	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	2973	97	22	50	0.7	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	CHEMBL437275	175537	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	2973	97	22	50	0.7	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	10007005	127571	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	523	13	1	7	6.1	C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC	10.1021/jm00006a002
	CHEMBL355503	127571	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	523	13	1	7	6.1	C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC	10.1021/jm00006a002
	10474602	32751	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	10	1	3	5.8	O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL135434	32751	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	10	1	3	5.8	O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	9999718	31838	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	378	8	2	4	5.1	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL134697	31838	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	378	8	2	4	5.1	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	10046386	35348	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL137654	35348	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	397	8	1	3	6.2	CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O	10.1021/jm00101a007
	10482767	175391	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	553	15	1	7	7.1	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2	10.1021/jm00006a002
	CHEMBL436047	175391	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	553	15	1	7	7.1	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2	10.1021/jm00006a002
	44384958	66653	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.0	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL172974	66653	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.0	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1	10.1016/S0960-894X(97)00134-0
	135507252	212376	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	438	13	3	5	5.0	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1	10.1021/jm00041a021
	CHEMBL81503	212376	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	438	13	3	5	5.0	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1	10.1021/jm00041a021
	10483151	66345	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	571	14	1	8	7.1	CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL171780	66345	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	571	14	1	8	7.1	CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	18373300	126103	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	492	8	1	5	6.5	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL344176	126103	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	492	8	1	5	6.5	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12	10.1016/j.bmcl.2003.08.070
	10406292	35169	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	361	9	1	3	5.4	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137504	35169	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	361	9	1	3	5.4	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	204055	215090	8	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	537	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL99099	215090	8	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	537	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	6444688	194099	35	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a008
	CHEMBL49302	194099	35	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a008
	6444688	194099	35	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a007
	CHEMBL49302	194099	35	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00101a007
	10023244	32934	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	389	9	1	3	6.1	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL135671	32934	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	389	9	1	3	6.1	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	9999755	33345	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL136094	33345	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10091738	34576	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	389	9	1	3	6.0	Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137089	34576	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	389	9	1	3	6.0	Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10475503	34781	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	390	9	2	4	5.3	CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137247	34781	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	390	9	2	4	5.3	CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10406292	35169	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	361	9	1	3	5.4	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137504	35169	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	361	9	1	3	5.4	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	9976757	35274	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	375	9	1	3	5.7	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137581	35274	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	375	9	1	3	5.7	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10362331	35498	4	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1	10.1021/jm00101a008
	CHEMBL137801	35498	4	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1	10.1021/jm00101a008
	10451768	34669	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	369	8	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1	10.1021/jm00101a007
	CHEMBL137168	34669	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	369	8	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1	10.1021/jm00101a007
	10387480	34785	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	421	8	1	5	5.6	CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1	10.1021/jm00101a007
	CHEMBL137248	34785	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	421	8	1	5	5.6	CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1	10.1021/jm00101a007
	10407251	125859	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	377	8	1	3	5.9	Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	CHEMBL342688	125859	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	377	8	1	3	5.9	Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1	10.1021/jm00101a007
	10024190	32745	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	404	10	1	4	5.5	CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL135431	32745	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	404	10	1	4	5.5	CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10362331	35498	4	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1	10.1021/jm00101a008
	CHEMBL137801	35498	4	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	379	9	1	3	5.6	O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1	10.1021/jm00101a008
	44403823	168724	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	3125	109	25	54	-4.2	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	CHEMBL415548	168724	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	3125	109	25	54	-4.2	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	129065	114322	29	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils	ChEMBL	377	4	3	6	3.2	Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C	10.1021/jm00045a011
	CHEMBL318809	114322	29	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils	ChEMBL	377	4	3	6	3.2	Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C	10.1021/jm00045a011
	18963030	21395	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	442	12	2	6	5.1	CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205054	21395	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	442	12	2	6	5.1	CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL47725	21395	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	442	12	2	6	5.1	CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	15666588	103651	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	358	11	1	2	6.1	Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1	10.1021/jm00095a011
	CHEMBL265563	103651	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	358	11	1	2	6.1	Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1	10.1021/jm00095a011
	15666614	118080	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	358	11	1	2	6.1	Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1	10.1021/jm00095a011
	CHEMBL326650	118080	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	358	11	1	2	6.1	Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1	10.1021/jm00095a011
	9841175	21421	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	CHEMBL1205297	21421	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	CHEMBL77513	21421	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	114999	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00126a001
	6156	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00126a001
	CHEMBL14823	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00126a001
	44213761	127511	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	346	9	3	3	3.7	O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1	10.1016/s0960-894x(00)00103-7
	CHEMBL354872	127511	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	346	9	3	3	3.7	O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1	10.1016/s0960-894x(00)00103-7
	114999	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00100a034
	6156	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00100a034
	CHEMBL14823	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00100a034
	10387303	34373	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	418	11	2	4	6.3	CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136955	34373	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	418	11	2	4	6.3	CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10427789	34713	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	347	8	1	3	5.0	O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137201	34713	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	347	8	1	3	5.0	O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10455429	35735	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	431	8	1	3	6.6	CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL138018	35735	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	431	8	1	3	6.6	CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	10430678	175188	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	393	9	1	4	5.6	COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1	10.1021/jm00101a007
	CHEMBL434810	175188	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	393	9	1	4	5.6	COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1	10.1021/jm00101a007
	10314767	35315	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	333	7	1	3	4.7	O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137633	35315	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	333	7	1	3	4.7	O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10407131	168735	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	9	1	3	5.7	Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1	10.1021/jm00101a008
	CHEMBL415687	168735	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	9	1	3	5.7	Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1	10.1021/jm00101a008
	114999	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00070a015
	6156	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00070a015
	CHEMBL14823	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00070a015
	15666630	14861	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	362	11	1	3	6.0	Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1	10.1021/jm00095a011
	CHEMBL109129	14861	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	362	11	1	3	6.0	Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1	10.1021/jm00095a011
	15666582	117463	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	360	12	1	3	5.5	COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1	10.1021/jm00095a011
	CHEMBL326000	117463	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	360	12	1	3	5.5	COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1	10.1021/jm00095a011
	44317392	212026	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	511	13	2	7	4.8	CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00041a021
	CHEMBL78859	212026	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	511	13	2	7	4.8	CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00041a021
	2487	9147	36	None	31	2	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80853-2
	5280492	9147	36	None	31	2	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80853-2
	CHEMBL65061	9147	36	None	31	2	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80853-2
	DB12961	9147	36	None	31	2	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80853-2
	114999	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00006a002
	6156	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00006a002
	CHEMBL14823	10311	21	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00006a002
	10053028	65780	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	540	13	2	8	5.9	CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL169120	65780	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	540	13	2	8	5.9	CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	6441619	213561	18	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960248s
	CHEMBL90214	213561	18	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960248s
	18963062	21554	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	404	13	2	6	4.8	CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1206683	21554	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	404	13	2	6	4.8	CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL295799	21554	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	404	13	2	6	4.8	CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	15666601	12918	1	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	302	9	1	2	4.7	O=C(O)CCCCc1sccc1CCCc1ccccc1	10.1021/jm00095a011
	CHEMBL108094	12918	1	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	302	9	1	2	4.7	O=C(O)CCCCc1sccc1CCCc1ccccc1	10.1021/jm00095a011
	15839733	52410	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	458	14	2	6	5.2	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O	10.1016/S0960-894X(00)80304-2
	CHEMBL15295	52410	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	458	14	2	6	5.2	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O	10.1016/S0960-894X(00)80304-2
	44296838	201619	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself	ChEMBL	334	14	2	2	5.4	CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O	10.1016/S0960-894X(01)80795-2
	CHEMBL53967	201619	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself	ChEMBL	334	14	2	2	5.4	CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O	10.1016/S0960-894X(01)80795-2
	15839729	213667	1	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1021/jm960088k
	CHEMBL15559	213667	1	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1021/jm960088k
	CHEMBL90788	213667	1	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1021/jm960088k
	15839729	213667	1	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	CHEMBL15559	213667	1	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	CHEMBL90788	213667	1	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	9955657	213434	15	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding	ChEMBL	455	13	2	5	4.9	COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1	10.1021/jm960088k
	CHEMBL89326	213434	15	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding	ChEMBL	455	13	2	5	4.9	COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1	10.1021/jm960088k
	9893718	213280	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm960088k
	CHEMBL292768	213280	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm960088k
	CHEMBL88337	213280	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm960088k
	9893718	213280	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL292768	213280	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL88337	213280	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	10046878	35206	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	405	10	1	4	5.7	COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137531	35206	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	405	10	1	4	5.7	COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	9976757	35274	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	9	1	3	5.7	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137581	35274	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	9	1	3	5.7	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10430674	126116	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	393	9	1	3	5.8	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL344230	126116	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	393	9	1	3	5.8	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O	10.1021/jm00101a008
	9912012	168983	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	458	12	2	6	4.9	CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	CHEMBL416277	168983	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	458	12	2	6	4.9	CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	10364772	34933	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	419	9	1	5	5.4	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137341	34933	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	419	9	1	5	5.4	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	204055	215090	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	537	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL99099	215090	8	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	537	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	135543808	212363	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	480	11	3	6	4.9	CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00041a021
	CHEMBL81401	212363	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	480	11	3	6	4.9	CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00041a021
	132379	118509	19	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm9506985
	CHEMBL328712	118509	19	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm9506985
	132379	118509	19	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	CHEMBL328712	118509	19	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	10292143	123375	1	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL336665	123375	1	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL48667	123375	1	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	10292143	123375	1	None	-	1	Human	8.3	pIC50	=	8.3	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80454-0
	CHEMBL336665	123375	1	None	-	1	Human	8.3	pIC50	=	8.3	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80454-0
	CHEMBL48667	123375	1	None	-	1	Human	8.3	pIC50	=	8.3	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80454-0
	10090758	65774	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	373	9	2	3	3.7	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1	10.1016/s0960-894x(00)00103-7
	CHEMBL169055	65774	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	373	9	2	3	3.7	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1	10.1016/s0960-894x(00)00103-7
	10047140	34380	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL136960	34380	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10001576	35154	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137494	35154	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	9999718	31838	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	378	8	2	4	5.1	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL134697	31838	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	378	8	2	4	5.1	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	14946858	35934	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	9	0	4	5.5	COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL138174	35934	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	375	9	0	4	5.5	COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10068808	34483	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	387	8	1	5	4.9	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1	10.1021/jm00101a007
	CHEMBL137030	34483	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	387	8	1	5	4.9	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1	10.1021/jm00101a007
	18373405	38471	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	525	7	1	3	7.3	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL140539	38471	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	525	7	1	3	7.3	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12	10.1016/j.bmcl.2003.08.070
	18373357	123571	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	461	7	1	3	6.9	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL337790	123571	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	461	7	1	3	6.9	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12	10.1016/j.bmcl.2003.08.070
	44359651	125961	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	481	7	1	3	7.2	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL343124	125961	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	481	7	1	3	7.2	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12	10.1016/j.bmcl.2003.08.070
	10021742	16228	6	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	CHEMBL111825	16228	6	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	10248148	122773	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	363	8	1	3	5.6	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL335525	122773	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	363	8	1	3	5.6	CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	44270188	58160	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	484	13	1	6	5.4	CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	CHEMBL15817	58160	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	484	13	1	6	5.4	CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	18963059	21396	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	402	11	2	6	4.7	CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205055	21396	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	402	11	2	6	4.7	CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL47726	21396	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	402	11	2	6	4.7	CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	204055	215090	8	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	537	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL99099	215090	8	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	537	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	60490	214040	106	None	-	0	Human	6.4	pIC50	=	6.4	Binding	In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils	ChEMBL	236	2	2	3	2.7	CC(c1cc2ccccc2s1)N(O)C(N)=O	10.1021/jm950725r
	CHEMBL93	214040	106	None	-	0	Human	6.4	pIC50	=	6.4	Binding	In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils	ChEMBL	236	2	2	3	2.7	CC(c1cc2ccccc2s1)N(O)C(N)=O	10.1021/jm950725r
	114999	10311	21	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00006a002
	6156	10311	21	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00006a002
	CHEMBL14823	10311	21	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00006a002
	9934323	107029	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00064a006
	CHEMBL288758	107029	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00064a006
	10170399	21594	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	1018	33	4	16	7.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1	10.1021/jm050383h
	CHEMBL1207275	21594	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	1018	33	4	16	7.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1	10.1021/jm050383h
	CHEMBL384950	21594	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)	ChEMBL	1018	33	4	16	7.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1	10.1021/jm050383h
	10415107	21670	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils	ChEMBL	504	4	2	7	4.1	CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21	10.1021/np50120a024
	CHEMBL1207951	21670	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils	ChEMBL	504	4	2	7	4.1	CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21	10.1021/np50120a024
	CHEMBL462734	21670	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils	ChEMBL	504	4	2	7	4.1	CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21	10.1021/np50120a024
	10022413	34431	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	376	9	2	4	5.0	Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136991	34431	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	376	9	2	4	5.0	Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10170399	21594	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)	ChEMBL	1018	33	4	16	7.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1	10.1021/jm050383h
	CHEMBL1207275	21594	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)	ChEMBL	1018	33	4	16	7.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1	10.1021/jm050383h
	CHEMBL384950	21594	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)	ChEMBL	1018	33	4	16	7.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1	10.1021/jm050383h
	15666610	14677	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	316	10	1	2	5.1	O=C(O)CCCCCc1sccc1CCCc1ccccc1	10.1021/jm00095a011
	CHEMBL109016	14677	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	316	10	1	2	5.1	O=C(O)CCCCCc1sccc1CCCc1ccccc1	10.1021/jm00095a011
	44385160	68126	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.0	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL176748	68126	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	5.0	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1	10.1016/S0960-894X(97)00134-0
	19427041	21415	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	534	14	3	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL1205171	21415	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	534	14	3	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL60881	21415	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	534	14	3	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	10023244	32934	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	389	9	1	3	6.1	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL135671	32934	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	389	9	1	3	6.1	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10047140	34380	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL136960	34380	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10475503	34781	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	390	9	2	4	5.3	CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137247	34781	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	390	9	2	4	5.3	CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10318241	35121	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	390	10	2	4	5.5	CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL137472	35121	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	390	10	2	4	5.5	CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10001576	35154	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137494	35154	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10436331	127322	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	509	13	2	7	5.0	CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL354553	127322	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	509	13	2	7	5.0	CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	15237280	64875	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	511	13	2	6	4.6	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL167474	64875	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	511	13	2	6	4.6	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	3368	7956	26	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	9867257	7956	26	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	CHEMBL51770	7956	26	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm00046a001
	135543742	212167	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	410	11	3	5	4.2	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1	10.1021/jm00041a021
	CHEMBL79991	212167	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	410	11	3	5	4.2	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1	10.1021/jm00041a021
	44348541	23592	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells	ChEMBL	323	7	1	2	3.0	CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1	10.1021/jm9506985
	CHEMBL124717	23592	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells	ChEMBL	323	7	1	2	3.0	CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1	10.1021/jm9506985
	44357534	33513	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	385	9	0	6	4.7	c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	CHEMBL136243	33513	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	385	9	0	6	4.7	c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1	10.1021/jm00101a008
	10341135	36161	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	403	10	1	3	6.5	CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL138380	36161	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	403	10	1	3	6.5	CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10427789	34713	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	347	8	1	3	5.0	O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137201	34713	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	347	8	1	3	5.0	O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10363959	35286	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	406	10	1	5	5.3	O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137594	35286	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	406	10	1	5	5.3	O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	10387480	34785	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	421	8	1	5	5.6	CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1	10.1021/jm00101a007
	CHEMBL137248	34785	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes	ChEMBL	421	8	1	5	5.6	CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1	10.1021/jm00101a007
	11725988	34759	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	359	8	1	5	4.2	c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1	10.1021/jm00101a007
	CHEMBL137234	34759	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	359	8	1	5	4.2	c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1	10.1021/jm00101a007
	10340408	125343	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	391	10	1	4	5.4	COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1	10.1021/jm00101a008
	CHEMBL341565	125343	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	391	10	1	4	5.4	COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1	10.1021/jm00101a008
	18373300	126103	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	492	8	1	5	6.5	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL344176	126103	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	492	8	1	5	6.5	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12	10.1016/j.bmcl.2003.08.070
	15666581	12420	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	346	11	2	3	5.2	O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1	10.1021/jm00095a011
	CHEMBL107781	12420	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	346	11	2	3	5.2	O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1	10.1021/jm00095a011
	10391552	127100	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	508	13	2	6	5.6	CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL352863	127100	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	508	13	2	6	5.6	CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	135507183	212421	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	396	10	3	5	3.8	CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1	10.1021/jm00041a021
	CHEMBL81817	212421	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	396	10	3	5	3.8	CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1	10.1021/jm00041a021
	44403823	168724	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)	ChEMBL	3125	109	25	54	-4.2	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	CHEMBL415548	168724	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)	ChEMBL	3125	109	25	54	-4.2	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	135507225	110998	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	424	12	3	5	4.6	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1	10.1021/jm00041a021
	CHEMBL309883	110998	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	424	12	3	5	4.6	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1	10.1021/jm00041a021
	10247237	35260	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	349	8	1	3	5.2	CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL137570	35260	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	349	8	1	3	5.2	CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	10032156	65791	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	647	16	1	8	8.6	CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL169246	65791	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	647	16	1	8	8.6	CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	9906324	21391	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205046	21391	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL46820	21391	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	9906324	21391	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80454-0
	CHEMBL1205046	21391	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80454-0
	CHEMBL46820	21391	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80454-0
	9865985	35446	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	405	9	1	5	5.2	O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137759	35446	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	405	9	1	5	5.2	O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1	10.1021/jm00101a008
	9978895	125754	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL342416	125754	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes	ChEMBL	409	9	1	3	6.3	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O	10.1021/jm00101a008
	6450158	193953	20	None	-	1	Human	8.2	pIC50	=	8.2	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	CHEMBL49210	193953	20	None	-	1	Human	8.2	pIC50	=	8.2	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	6450158	193953	20	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1021/jm00064a006
	CHEMBL49210	193953	20	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1021/jm00064a006
	135516891	164295	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	384	10	3	6	3.8	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1	10.1021/jm00041a021
	CHEMBL407983	164295	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	384	10	3	6	3.8	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1	10.1021/jm00041a021
	18963040	21640	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL1207571	21640	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL416259	21640	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	10364772	34933	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	419	9	1	5	5.4	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137341	34933	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	419	9	1	5	5.4	CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10092630	34594	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	404	9	2	4	5.7	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137104	34594	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	404	9	2	4	5.7	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	132425	13637	5	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	358	11	1	2	6.1	CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	CHEMBL108415	13637	5	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	358	11	1	2	6.1	CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	11799000	23940	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN	ChEMBL	482	9	1	4	5.1	CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1	10.1021/jm950699x
	CHEMBL125611	23940	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN	ChEMBL	482	9	1	4	5.1	CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1	10.1021/jm950699x
	10319829	32890	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	417	11	1	3	6.9	CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL135612	32890	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	417	11	1	3	6.9	CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10363959	35286	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	406	10	1	5	5.3	O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137594	35286	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	406	10	1	5	5.3	O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	15666631	14859	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	346	11	2	3	5.0	O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1	10.1021/jm00095a011
	CHEMBL109128	14859	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	346	11	2	3	5.0	O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1	10.1021/jm00095a011
	44379572	127078	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	540	10	2	4	5.3	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1	10.1016/s0960-894x(00)00103-7
	CHEMBL352717	127078	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	540	10	2	4	5.3	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1	10.1016/s0960-894x(00)00103-7
	9849151	65870	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	508	13	2	6	5.6	CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL169683	65870	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	508	13	2	6	5.6	CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	15839731	56225	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	430	13	2	6	4.4	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O	10.1016/S0960-894X(00)80304-2
	CHEMBL15648	56225	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	430	13	2	6	4.4	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O	10.1016/S0960-894X(00)80304-2
	10339300	137003	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	373	6	2	3	4.7	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL367943	137003	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	373	6	2	3	4.7	COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	10341242	34926	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	405	10	1	4	5.7	COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1	10.1021/jm00101a008
	CHEMBL137336	34926	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	405	10	1	4	5.7	COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1	10.1021/jm00101a008
	10477988	34916	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	433	9	1	5	5.8	CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137330	34916	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	433	9	1	5	5.8	CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	44357546	123531	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	399	9	0	6	5.2	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1	10.1021/jm00101a008
	CHEMBL337563	123531	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	399	9	0	6	5.2	CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1	10.1021/jm00101a008
	9911868	24806	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined	ChEMBL	455	11	1	7	4.9	COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1	10.1016/S0960-894X(97)00025-5
	CHEMBL126463	24806	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined	ChEMBL	455	11	1	7	4.9	COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1	10.1016/S0960-894X(97)00025-5
	15666586	115344	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	344	11	1	2	5.8	Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1	10.1021/jm00095a011
	CHEMBL320258	115344	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	344	11	1	2	5.8	Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1	10.1021/jm00095a011
	44379573	64874	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	414	10	2	4	4.7	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1	10.1016/s0960-894x(00)00103-7
	CHEMBL167465	64874	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes	ChEMBL	414	10	2	4	4.7	CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1	10.1016/s0960-894x(00)00103-7
	10019853	35309	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	335	8	1	3	4.9	O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1	10.1021/jm00101a007
	CHEMBL137625	35309	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	335	8	1	3	4.9	O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1	10.1021/jm00101a007
	10337448	34880	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	342	8	0	3	5.9	N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	CHEMBL137307	34880	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.	ChEMBL	342	8	0	3	5.9	N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm00101a008
	9841175	21421	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	CHEMBL1205297	21421	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	CHEMBL77513	21421	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	44315539	21569	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	312	10	3	3	3.7	CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1	10.1016/0960-894X(96)00424-6
	CHEMBL1206776	21569	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	312	10	3	3	3.7	CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1	10.1016/0960-894X(96)00424-6
	CHEMBL305933	21569	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	312	10	3	3	3.7	CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1	10.1016/0960-894X(96)00424-6
	135430350	174833	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	452	13	3	5	5.2	CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC	10.1021/jm00041a021
	CHEMBL432363	174833	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	452	13	3	5	5.2	CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC	10.1021/jm00041a021
	10021742	16228	6	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	CHEMBL111825	16228	6	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	10349070	137666	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	630	16	2	7	7.9	CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL368540	137666	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.	ChEMBL	630	16	2	7	7.9	CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	10481412	66559	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	509	13	1	7	5.9	CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL172628	66559	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	509	13	1	7	5.9	CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	44384957	173017	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	389	7	2	4	4.3	COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL426773	173017	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	389	7	2	4	4.3	COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	44403368	168106	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)	ChEMBL	2750	92	21	47	-1.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	CHEMBL412510	168106	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)	ChEMBL	2750	92	21	47	-1.6	CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1	10.1021/jm050383h
	3368	7956	26	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm960088k
	9867257	7956	26	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm960088k
	CHEMBL51770	7956	26	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding	ChEMBL	428	5	2	3	5.5	OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1	10.1021/jm960088k
	9958915	64897	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	CHEMBL167669	64897	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2	10.1016/S0960-894X(01)80853-2
	10741106	124580	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane	ChEMBL	426	9	0	4	4.7	CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21	10.1021/jm950699x
	CHEMBL340180	124580	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane	ChEMBL	426	9	0	4	4.7	CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21	10.1021/jm950699x
	15666623	174575	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	434	12	1	2	7.8	CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	CHEMBL430520	174575	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL	434	12	1	2	7.8	CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O	10.1021/jm00095a011
	9841175	21421	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	CHEMBL1205297	21421	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	CHEMBL77513	21421	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	346	9	3	3	3.7	O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1	10.1016/0960-894X(96)00424-6
	11740566	126225	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	381	8	1	3	5.7	CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	CHEMBL345047	126225	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	381	8	1	3	5.7	CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O	10.1021/jm00101a007
	9934500	172380	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	472	7	1	4	6.4	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL424290	172380	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay	ChEMBL	472	7	1	4	6.4	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12	10.1016/j.bmcl.2003.08.070
	44315583	21420	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	284	8	3	3	2.9	CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1	10.1016/0960-894X(96)00424-6
	CHEMBL1205289	21420	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	284	8	3	3	2.9	CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1	10.1016/0960-894X(96)00424-6
	CHEMBL76530	21420	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand	ChEMBL	284	8	3	3	2.9	CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1	10.1016/0960-894X(96)00424-6
	9976891	34940	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	377	8	1	3	5.9	Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1	10.1021/jm00101a007
	CHEMBL137346	34940	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes	ChEMBL	377	8	1	3	5.9	Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1	10.1021/jm00101a007
	135543741	212375	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	410	11	3	5	4.7	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1	10.1021/jm00041a021
	CHEMBL81489	212375	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	410	11	3	5	4.7	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1	10.1021/jm00041a021
	44385920	68156	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	343	5	2	2	4.7	O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1016/S0960-894X(97)00134-0
	CHEMBL176974	68156	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	343	5	2	2	4.7	O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O	10.1016/S0960-894X(97)00134-0
	15718085	108122	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O	10.1021/jm00064a006
	CHEMBL296869	108122	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils	ChEMBL	468	14	2	5	6.2	CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O	10.1021/jm00064a006
	135507273	212074	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	452	13	3	5	5.2	CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC	10.1021/jm00041a021
	CHEMBL79233	212074	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	452	13	3	5	5.2	CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC	10.1021/jm00041a021
	122023	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80999-9
	CHEMBL15766	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80999-9
	CHEMBL45460	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80999-9
	4534	198681	94	None	-	0	Human	7.1	pIC50	=	7.1	Binding	The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN	ChEMBL	302	5	4	4	3.6	CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1	10.1021/jm00085a019
	CHEMBL52	198681	94	None	-	0	Human	7.1	pIC50	=	7.1	Binding	The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN	ChEMBL	302	5	4	4	3.6	CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1	10.1021/jm00085a019
	122023	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL15766	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL45460	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	122023	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80304-2
	CHEMBL15766	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80304-2
	CHEMBL45460	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80304-2
	122023	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1021/jm00041a021
	CHEMBL15766	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1021/jm00041a021
	CHEMBL45460	57569	60	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1021/jm00041a021
	135500104	170552	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	410	11	3	5	4.2	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1	10.1021/jm00041a021
	CHEMBL420576	170552	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	410	11	3	5	4.2	CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1	10.1021/jm00041a021
	10347709	65876	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	557	13	2	8	6.6	CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL169722	65876	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	557	13	2	8	6.6	CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	135457469	112417	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	398	10	2	7	3.8	CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1	10.1021/jm00041a021
	CHEMBL312483	112417	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN	ChEMBL	398	10	2	7	3.8	CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1	10.1021/jm00041a021
	10092630	34594	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	404	9	2	4	5.7	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	CHEMBL137104	34594	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.	ChEMBL	404	9	2	4	5.7	CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O	10.1021/jm00101a008
	10737187	22291	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells	ChEMBL	359	8	0	2	4.5	CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1	10.1021/jm9506985
	CHEMBL121748	22291	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells	ChEMBL	359	8	0	2	4.5	CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1	10.1021/jm9506985
	18373357	123571	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	461	7	1	3	6.9	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12	10.1016/j.bmcl.2003.08.070
	CHEMBL337790	123571	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay	ChEMBL	461	7	1	3	6.9	COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12	10.1016/j.bmcl.2003.08.070
	44386171	68148	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	377	5	2	2	5.4	O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl	10.1016/S0960-894X(97)00134-0
	CHEMBL176903	68148	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	377	5	2	2	5.4	O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl	10.1016/S0960-894X(97)00134-0
	10052575	65728	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	525	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	CHEMBL168944	65728	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor	ChEMBL	525	13	1	7	6.4	CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2	10.1021/jm00006a002
	44385966	67200	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	4.8	COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	CHEMBL175128	67200	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils	ChEMBL	387	6	2	3	4.8	COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1	10.1016/S0960-894X(97)00134-0
	25114442	9835	56	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5212743
	5817	9835	56	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5212743
	CHEMBL3286797	9835	56	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5212743
	DB12024	9835	56	None	-	1	Human	5.0	pIC50	=	5.0	Binding	Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5212743
	192617	107528	22	None	-	1	Human	10.4	pKi	=	10.4	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL292782	107528	22	None	-	1	Human	10.4	pKi	=	10.4	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	192617	107528	22	None	-	1	Human	10.4	pKi	=	10.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL292782	107528	22	None	-	1	Human	10.4	pKi	=	10.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	19600933	209579	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	534	13	3	5	5.8	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL62265	209579	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	534	13	3	5	5.8	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	10745838	124840	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	582	12	3	7	6.4	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL340460	124840	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	582	12	3	7	6.4	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	2487	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	5280492	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL65061	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	DB12961	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80999-9
	2487	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	5280492	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL65061	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	DB12961	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	2487	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	5280492	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	CHEMBL65061	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	DB12961	9147	36	None	31	2	Human	9.9	pKi	=	9.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	132379	118509	19	None	-	1	Human	9.9	pKi	=	9.9	Binding	Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	CHEMBL328712	118509	19	None	-	1	Human	9.9	pKi	=	9.9	Binding	Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	10120811	103227	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL262231	103227	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	192617	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00046a017
	CHEMBL292782	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00046a017
	192617	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm960088k
	CHEMBL292782	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm960088k
	192617	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL292782	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	192617	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL292782	107528	22	None	-	1	Human	9.3	pKi	=	9.3	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	600	12	3	7	6.6	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	10745838	124840	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	582	12	3	7	6.4	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL340460	124840	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	582	12	3	7	6.4	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	6441619	213561	18	None	-	1	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960248s
	CHEMBL90214	213561	18	None	-	1	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960248s
	6441619	213561	18	None	-	1	Human	9.1	pKi	=	9.1	Binding	Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960088k
	CHEMBL90214	213561	18	None	-	1	Human	9.1	pKi	=	9.1	Binding	Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor	ChEMBL	459	9	1	4	6.4	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1	10.1021/jm960088k
	9850643	214465	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	554	19	2	6	6.4	CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O	10.1021/jm00046a017
	CHEMBL95453	214465	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	554	19	2	6	6.4	CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O	10.1021/jm00046a017
	15658147	16356	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	411	13	3	4	5.2	CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a013
	CHEMBL112487	16356	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	411	13	3	4	5.2	CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a013
	CHEMBL112520	16356	0	None	-	1	Human	9.0	pKi	=	9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	411	13	3	4	5.2	CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a013
	9850974	213046	0	None	-	1	Human	9.0	pKi	=	9	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	568	20	2	6	6.8	CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O	10.1021/jm960088k
	CHEMBL86900	213046	0	None	-	1	Human	9.0	pKi	=	9	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	568	20	2	6	6.8	CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O	10.1021/jm960088k
	15658147	16356	0	None	-	1	Human	9.0	pKi	=	9	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	411	13	3	4	5.2	CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a012
	CHEMBL112487	16356	0	None	-	1	Human	9.0	pKi	=	9	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	411	13	3	4	5.2	CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a012
	CHEMBL112520	16356	0	None	-	1	Human	9.0	pKi	=	9	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	411	13	3	4	5.2	CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a012
	10120811	103227	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL262231	103227	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	19600933	209579	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	534	13	3	5	5.8	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL62265	209579	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	534	13	3	5	5.8	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	9893718	213280	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL292768	213280	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL88337	213280	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	10529082	25590	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	489	10	1	5	6.4	COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	CHEMBL127913	25590	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	489	10	1	5	6.4	COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	9893718	213280	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL292768	213280	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL88337	213280	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	204058	170238	8	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2	10.1021/jm00046a017
	CHEMBL419948	170238	8	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	539	15	2	6	5.4	CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2	10.1021/jm00046a017
	10529241	25284	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	493	9	1	4	7.1	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1	10.1021/jm960248s
	CHEMBL127376	25284	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	493	9	1	4	7.1	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1	10.1021/jm960248s
	10648186	24939	1	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	473	10	1	4	6.8	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1	10.1021/jm960248s
	CHEMBL126976	24939	1	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	473	10	1	4	6.8	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1	10.1021/jm960248s
	11798848	23304	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	477	9	1	4	6.5	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1	10.1021/jm960248s
	CHEMBL123722	23304	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	477	9	1	4	6.5	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1	10.1021/jm960248s
	9958441	123612	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	517	12	1	5	7.2	COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	CHEMBL337995	123612	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	517	12	1	5	7.2	COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	2487	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	5280492	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL65061	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	DB12961	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1016/S0960-894X(01)80105-0
	2487	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	5280492	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	CHEMBL65061	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	DB12961	9147	36	None	31	2	Human	8.7	pKi	=	8.7	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/jm00076a030
	18963032	107869	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	444	11	2	6	4.5	CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	CHEMBL294987	107869	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	444	11	2	6	4.5	CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	44340787	21353	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	435	12	3	4	6.0	CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL1204561	21353	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	435	12	3	4	6.0	CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL326397	21353	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	435	12	3	4	6.0	CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	15839729	213667	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	CHEMBL15559	213667	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	CHEMBL90788	213667	1	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	456	11	2	6	4.7	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	10046307	21568	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	374	12	2	5	4.7	CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1206771	21568	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	374	12	2	5	4.7	CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL305560	21568	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	374	12	2	5	4.7	CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	15658110	21346	0	None	-	1	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	419	12	2	3	6.5	CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL113528	21346	0	None	-	1	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	419	12	2	3	6.5	CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL1204495	21346	0	None	-	1	Human	7.0	pKi	=	7	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	419	12	2	3	6.5	CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	15658157	21347	0	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	449	12	3	5	4.9	CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1	10.1021/jm00074a012
	CHEMBL114454	21347	0	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	449	12	3	5	4.9	CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1	10.1021/jm00074a012
	CHEMBL1204496	21347	0	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	449	12	3	5	4.9	CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1	10.1021/jm00074a012
	10037501	191503	4	None	-	1	Human	4.0	pKi	=	4	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	245	1	1	5	0.5	CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N	10.1021/np50100a005
	CHEMBL485053	191503	4	None	-	1	Human	4.0	pKi	=	4	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	245	1	1	5	0.5	CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N	10.1021/np50100a005
	18963059	21396	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	402	11	2	6	4.7	CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205055	21396	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	402	11	2	6	4.7	CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL47726	21396	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	402	11	2	6	4.7	CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	14977959	16259	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	506	15	2	5	6.0	Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	CHEMBL112018	16259	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	506	15	2	5	6.0	Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	18963030	21395	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	442	12	2	6	5.1	CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205054	21395	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	442	12	2	6	5.1	CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL47725	21395	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	442	12	2	6	5.1	CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	21765776	170470	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL420488	170470	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	14977907	16322	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	483	18	2	5	6.8	CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	CHEMBL112310	16322	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	483	18	2	5	6.8	CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	14977965	118126	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	524	15	2	5	6.2	Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	CHEMBL326909	118126	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	524	15	2	5	6.2	Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	11798329	25277	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	463	8	1	4	6.5	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1	10.1021/jm960248s
	CHEMBL127341	25277	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	463	8	1	4	6.5	O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1	10.1021/jm960248s
	11800543	26163	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	538	11	2	6	6.7	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL129272	26163	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	538	11	2	6	6.7	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	122023	57569	60	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL15766	57569	60	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL45460	57569	60	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	23257866	16238	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	515	18	2	5	6.5	CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	CHEMBL111908	16238	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	515	18	2	5	6.5	CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	10021742	16228	6	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	CHEMBL111825	16228	6	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/np50100a005
	14977963	16415	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	574	15	2	5	7.1	Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	CHEMBL112737	16415	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	574	15	2	5	7.1	Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	9829619	107529	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL292783	107529	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	9977200	36149	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	360	11	2	5	4.3	CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL138370	36149	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	360	11	2	5	4.3	CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL60617	36149	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	360	11	2	5	4.3	CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	10292143	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL336665	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL48667	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	10292143	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL336665	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL48667	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	10292143	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80454-0
	CHEMBL336665	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80454-0
	CHEMBL48667	123375	1	None	-	1	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80454-0
	18963040	21640	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1207571	21640	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL416259	21640	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	15658122	16536	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	453	12	2	4	6.0	CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL113514	16536	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	453	12	2	4	6.0	CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	15658098	176095	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	383	13	2	3	6.3	CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1	10.1021/jm00074a012
	CHEMBL441647	176095	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	383	13	2	3	6.3	CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1	10.1021/jm00074a012
	14977952	115814	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	676	19	2	7	7.3	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL321261	115814	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	676	19	2	7	7.3	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	14977946	117357	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	531	18	2	6	6.2	CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	CHEMBL325423	117357	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	531	18	2	6	6.2	CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	44270188	58160	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	484	13	1	6	5.4	CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	CHEMBL15817	58160	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	484	13	1	6	5.4	CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80304-2
	9984593	16409	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	533	17	2	5	7.3	O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1	10.1021/jm00046a017
	CHEMBL112707	16409	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	533	17	2	5	7.3	O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1	10.1021/jm00046a017
	15839733	52410	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	458	14	2	6	5.2	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O	10.1016/S0960-894X(00)80304-2
	CHEMBL15295	52410	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	458	14	2	6	5.2	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O	10.1016/S0960-894X(00)80304-2
	14977913	16033	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	549	17	2	6	5.7	COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL110797	16033	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	549	17	2	6	5.7	COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	14977924	117724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	565	17	2	6	6.2	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL326192	117724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	565	17	2	6	6.2	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	10812265	64921	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	424	11	2	6	5.1	CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL167923	64921	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	424	11	2	6	5.1	CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	10475982	168603	0	None	-15	2	Human	4.8	pKi	=	4.8	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	CHEMBL414462	168603	0	None	-15	2	Human	4.8	pKi	=	4.8	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	21765774	16473	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	579	18	2	6	6.3	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL113146	16473	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	579	18	2	6	6.3	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	14977898	16862	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	519	15	3	6	5.3	COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL115437	16862	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	519	15	3	6	5.3	COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	14977924	117724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	565	17	2	6	6.2	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL326192	117724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	565	17	2	6	6.2	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	10405361	21417	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	346	10	2	5	3.9	CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1205188	21417	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	346	10	2	5	3.9	CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL62051	21417	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	346	10	2	5	3.9	CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	15839732	52461	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	444	13	2	6	4.8	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O	10.1016/S0960-894X(00)80304-2
	CHEMBL15299	52461	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	444	13	2	6	4.8	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O	10.1016/S0960-894X(00)80304-2
	44382468	65862	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL169639	65862	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	44341107	16232	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	277	4	1	3	3.2	Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1	10.1021/jm00074a014
	CHEMBL111872	16232	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	277	4	1	3	3.2	Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1	10.1021/jm00074a014
	23257889	16274	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	535	17	1	6	7.5	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL112088	16274	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	535	17	1	6	7.5	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	132379	118509	19	None	-	1	Human	8.7	pKi	=	8.7	Binding	Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	CHEMBL328712	118509	19	None	-	1	Human	8.7	pKi	=	8.7	Binding	Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00100a034
	132379	118509	19	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00070a015
	CHEMBL328712	118509	19	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00070a015
	132379	118509	19	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00046a017
	CHEMBL328712	118509	19	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	453	9	1	3	5.4	CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12	10.1021/jm00046a017
	10694814	23342	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	449	12	1	5	5.9	COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	CHEMBL123862	23342	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	449	12	1	5	5.9	COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	2487	9147	36	None	31	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/np50094a001
	5280492	9147	36	None	31	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/np50094a001
	CHEMBL65061	9147	36	None	31	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/np50094a001
	DB12961	9147	36	None	31	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R	ChEMBL	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	10.1021/np50094a001
	10182429	64913	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	428	10	2	5	5.7	CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL167850	64913	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	428	10	2	5	5.7	CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	11800543	26163	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	538	11	2	6	6.7	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL129272	26163	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	538	11	2	6	6.7	CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	18963040	21640	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1207571	21640	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL416259	21640	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	18963040	21640	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL1207571	21640	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	CHEMBL416259	21640	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	404	14	2	6	5.0	CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/S0960-894X(00)80453-9
	114999	10311	21	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00074a014
	6156	10311	21	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00074a014
	CHEMBL14823	10311	21	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1021/jm00074a014
	44341141	16206	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	667	18	1	7	6.9	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL111723	16206	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	667	18	1	7	6.9	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	23257891	16477	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	551	17	1	6	6.5	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL113167	16477	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	551	17	1	6	6.5	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	10325873	16291	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	579	18	2	6	6.3	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL112169	16291	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	579	18	2	6	6.3	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	44382378	65643	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL168854	65643	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	44341318	16321	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	349	8	2	4	3.5	Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1	10.1021/jm00074a014
	CHEMBL112309	16321	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	349	8	2	4	3.5	Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1	10.1021/jm00074a014
	23257882	117192	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	564	17	1	6	6.5	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL324478	117192	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	564	17	1	6	6.5	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	10745069	36869	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	542	13	2	4	7.9	CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC	10.1021/jm00022a006
	CHEMBL138954	36869	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	542	13	2	4	7.9	CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC	10.1021/jm00022a006
	177941	8369	50	None	-	1	Human	7.6	pKi	=	7.6	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	10.1021/jm960088k
	2948	8369	50	None	-	1	Human	7.6	pKi	=	7.6	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	10.1021/jm960088k
	CHEMBL329123	8369	50	None	-	1	Human	7.6	pKi	=	7.6	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	10.1021/jm960088k
	DB12850	8369	50	None	-	1	Human	7.6	pKi	=	7.6	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	10.1021/jm960088k
	9906324	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL1205046	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL46820	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	9906324	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205046	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL46820	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	9906324	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80454-0
	CHEMBL1205046	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80454-0
	CHEMBL46820	21391	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80454-0
	14977920	16251	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	515	18	2	5	6.5	CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	CHEMBL111969	16251	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	515	18	2	5	6.5	CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	44341073	16900	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	307	5	1	4	3.2	COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1	10.1021/jm00074a014
	CHEMBL115679	16900	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	307	5	1	4	3.2	COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1	10.1021/jm00074a014
	10324028	16800	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	509	15	2	6	5.6	COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1	10.1021/jm00046a017
	CHEMBL115040	16800	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	509	15	2	6	5.6	COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1	10.1021/jm00046a017
	44302963	21413	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	402	14	2	5	5.5	CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1205145	21413	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	402	14	2	5	5.5	CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL58794	21413	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	402	14	2	5	5.5	CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	9826485	113141	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs	ChEMBL	469	16	3	5	5.7	CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00070a015
	CHEMBL313923	113141	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs	ChEMBL	469	16	3	5	5.7	CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00070a015
	114999	10311	21	None	-	1	Human	6.6	pKi	=	6.6	Binding	In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/0960-894X(95)00135-G
	6156	10311	21	None	-	1	Human	6.6	pKi	=	6.6	Binding	In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/0960-894X(95)00135-G
	CHEMBL14823	10311	21	None	-	1	Human	6.6	pKi	=	6.6	Binding	In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay	ChEMBL	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	10.1016/0960-894X(95)00135-G
	15658099	170112	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	385	14	2	3	6.2	CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1	10.1021/jm00074a012
	CHEMBL419036	170112	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	385	14	2	3	6.2	CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1	10.1021/jm00074a012
	9826485	113141	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	469	16	3	5	5.7	CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	CHEMBL313923	113141	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	469	16	3	5	5.7	CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O	10.1021/jm00074a013
	14977927	17028	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	652	18	2	7	7.7	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL116101	17028	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	652	18	2	7	7.7	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	15658155	21344	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	447	11	3	5	5.0	CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1	10.1021/jm00074a012
	CHEMBL113288	21344	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	447	11	3	5	5.0	CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1	10.1021/jm00074a012
	CHEMBL1204493	21344	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	447	11	3	5	5.0	CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1	10.1021/jm00074a012
	10179915	64881	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	412	10	2	5	5.2	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL167520	64881	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	412	10	2	5	5.2	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	44302965	205733	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor	ChEMBL	551	14	1	7	6.5	CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2	10.1021/jm990504b
	CHEMBL58495	205733	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor	ChEMBL	551	14	1	7	6.5	CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2	10.1021/jm990504b
	192624	175270	2	None	-	1	Human	8.5	pKi	=	8.5	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	394	10	2	5	5.1	CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL435273	175270	2	None	-	1	Human	8.5	pKi	=	8.5	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	394	10	2	5	5.1	CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	9912012	168983	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	458	12	2	6	4.9	CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	CHEMBL416277	168983	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	458	12	2	6	4.9	CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2	10.1016/S0960-894X(00)80454-0
	9906324	21391	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL1205046	21391	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL46820	21391	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor	ChEMBL	348	10	2	6	3.4	CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	6157	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm960088k
	6438358	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm960088k
	CHEMBL422420	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm960088k
	44302966	103274	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor	ChEMBL	484	13	2	6	4.9	CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO	10.1021/jm990504b
	CHEMBL262530	103274	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor	ChEMBL	484	13	2	6	4.9	CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO	10.1021/jm990504b
	10554820	37052	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	556	13	2	5	7.5	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O	10.1021/jm00022a006
	CHEMBL139115	37052	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	556	13	2	5	7.5	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O	10.1021/jm00022a006
	44302963	21413	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	402	14	2	5	5.5	CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1205145	21413	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	402	14	2	5	5.5	CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL58794	21413	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	402	14	2	5	5.5	CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	9845585	64930	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	408	10	2	5	5.4	CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL168011	64930	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	408	10	2	5	5.4	CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	44382275	66511	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL172457	66511	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	44382384	66316	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL171666	66316	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	14977911	16371	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	499	18	2	5	6.0	CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O	10.1021/jm00074a013
	CHEMBL112544	16371	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	499	18	2	5	6.0	CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O	10.1021/jm00074a013
	14977931	16428	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	520	16	2	6	7.0	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL112808	16428	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	520	16	2	6	7.0	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	10021742	16228	6	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/jm00074a014
	CHEMBL111825	16228	6	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	365	4	1	7	2.6	Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2	10.1021/jm00074a014
	14977957	16292	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	490	15	2	5	7.0	Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	CHEMBL112176	16292	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	490	15	2	5	7.0	Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	14977933	16662	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	552	16	2	7	5.7	COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL114290	16662	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	552	16	2	7	5.7	COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	10507666	37691	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	592	13	2	6	7.1	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O	10.1021/jm00022a006
	CHEMBL139799	37691	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	592	13	2	6	7.1	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O	10.1021/jm00022a006
	9807782	26200	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	556	11	2	6	6.9	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL129463	26200	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	556	11	2	6	6.9	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	6444688	194099	35	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00074a014
	CHEMBL49302	194099	35	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1021/jm00074a014
	23257894	16427	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	521	16	1	5	6.5	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL112804	16427	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	521	16	1	5	6.5	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	10342316	64925	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	424	11	2	6	5.1	CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL167972	64925	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	424	11	2	6	5.1	CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	10363485	65877	0	None	-29	2	Human	4.4	pKi	=	4.4	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	CHEMBL169743	65877	0	None	-29	2	Human	4.4	pKi	=	4.4	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	9800998	106144	2	None	-32	2	Human	4.4	pKi	=	4.4	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	CHEMBL282524	106144	2	None	-32	2	Human	4.4	pKi	=	4.4	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	9829619	107529	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	CHEMBL292783	107529	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil	ChEMBL	574	14	3	6	7.1	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O	10.1016/S0960-894X(01)80105-0
	44382463	65998	0	None	-9	2	Human	4.4	pKi	=	4.4	Binding	In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	CHEMBL170226	65998	0	None	-9	2	Human	4.4	pKi	=	4.4	Binding	In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay	ChEMBL	398	5	1	5	4.5	O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1	10.1016/0960-894X(95)00135-G
	6157	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm00070a015
	6438358	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm00070a015
	CHEMBL422420	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm00070a015
	6157	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm00046a017
	6438358	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm00046a017
	CHEMBL422420	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	10.1021/jm00046a017
	9807782	26200	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	556	11	2	6	6.9	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL129463	26200	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor	ChEMBL	556	11	2	6	6.9	CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	9893718	213280	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL292768	213280	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	CHEMBL88337	213280	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor	ChEMBL	548	12	3	8	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O	10.1021/jm00076a030
	3083459	127166	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	412	10	2	5	5.2	CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL353378	127166	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	412	10	2	5	5.2	CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	6439436	16326	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	536	16	2	6	6.0	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL112338	16326	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	536	16	2	6	6.0	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	6439436	16326	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	536	16	2	6	6.0	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	CHEMBL112338	16326	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	536	16	2	6	6.0	COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	10292143	123375	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL336665	123375	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL48667	123375	1	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	362	11	2	6	3.8	CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	10050724	16896	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	477	13	2	5	5.7	O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1	10.1021/jm00046a017
	CHEMBL115658	16896	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	477	13	2	5	5.7	O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1	10.1021/jm00046a017
	15839731	56225	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	430	13	2	6	4.4	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O	10.1016/S0960-894X(00)80304-2
	CHEMBL15648	56225	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	430	13	2	6	4.4	CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O	10.1016/S0960-894X(00)80304-2
	9872540	37214	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	560	13	2	5	8.4	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O	10.1021/jm00022a006
	CHEMBL139254	37214	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	560	13	2	5	8.4	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O	10.1021/jm00022a006
	14977894	117384	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	471	17	3	5	5.6	CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O	10.1021/jm00074a013
	CHEMBL325615	117384	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	471	17	3	5	5.6	CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O	10.1021/jm00074a013
	14977961	16282	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	558	15	2	5	8.0	Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	CHEMBL112135	16282	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	558	15	2	5	8.0	Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1	10.1021/jm00074a013
	6450158	193953	20	None	-	1	Human	7.4	pKi	=	7.4	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	CHEMBL49210	193953	20	None	-	1	Human	7.4	pKi	=	7.4	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	14977916	118102	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	515	18	2	5	6.5	CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O	10.1021/jm00074a013
	CHEMBL326779	118102	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	515	18	2	5	6.5	CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O	10.1021/jm00074a013
	10405361	21417	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	346	10	2	5	3.9	CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1205188	21417	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	346	10	2	5	3.9	CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL62051	21417	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	346	10	2	5	3.9	CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	9977200	36149	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	360	11	2	5	4.3	CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL138370	36149	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	360	11	2	5	4.3	CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL60617	36149	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	360	11	2	5	4.3	CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	21765772	117387	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL325637	117387	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	10793277	37858	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	576	13	2	5	7.4	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O	10.1021/jm00022a006
	CHEMBL139969	37858	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand	ChEMBL	576	13	2	5	7.4	CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O	10.1021/jm00022a006
	6450158	193953	20	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1021/jm00064a006
	CHEMBL49210	193953	20	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils	ChEMBL	516	12	2	6	5.9	COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1	10.1021/jm00064a006
	15658112	69948	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	419	12	2	3	6.5	CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL1788228	69948	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	419	12	2	3	6.5	CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL1789864	69948	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	419	12	2	3	6.5	CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	15658139	21348	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	452	12	2	3	6.6	CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1	10.1021/jm00074a012
	CHEMBL115826	21348	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	452	12	2	3	6.6	CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1	10.1021/jm00074a012
	CHEMBL1204497	21348	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	452	12	2	3	6.6	CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1	10.1021/jm00074a012
	18963028	21394	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	376	11	2	6	4.2	CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1205053	21394	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	376	11	2	6	4.2	CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL47716	21394	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	376	11	2	6	4.2	CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	44382276	127094	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	CHEMBL352814	127094	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)	ChEMBL	412	5	1	5	5.1	CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1	10.1016/0960-894X(95)00135-G
	10371282	117390	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	595	18	2	7	6.0	COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL325643	117390	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	595	18	2	7	6.0	COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	20704716	191504	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	488	5	1	9	2.4	CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O	10.1021/np50100a005
	CHEMBL485054	191504	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane	ChEMBL	488	5	1	9	2.4	CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O	10.1021/np50100a005
	10159791	64782	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	408	10	2	5	5.4	CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL167261	64782	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	408	10	2	5	5.4	CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	10046307	21568	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	374	12	2	5	4.7	CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL1206771	21568	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	374	12	2	5	4.7	CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	CHEMBL305560	21568	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.	ChEMBL	374	12	2	5	4.7	CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O	10.1016/0960-894X(95)00340-Y
	19427041	21415	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	534	14	3	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL1205171	21415	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	534	14	3	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	CHEMBL60881	21415	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	534	14	3	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O	10.1016/S0960-894X(01)80999-9
	15658149	21343	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	413	14	3	4	5.1	CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a012
	CHEMBL111811	21343	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	413	14	3	4	5.1	CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a012
	CHEMBL1204492	21343	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	413	14	3	4	5.1	CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1	10.1021/jm00074a012
	15658119	16583	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	437	12	2	4	7.0	CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	CHEMBL113792	16583	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	437	12	2	4	7.0	CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1	10.1021/jm00074a012
	14977948	16364	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	660	19	2	7	8.2	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL112510	16364	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	660	19	2	7	8.2	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	9845587	172408	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	408	10	2	5	5.4	CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL424361	172408	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	408	10	2	5	5.4	CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	10670634	64450	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	437	11	2	6	5.1	CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL166862	64450	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	437	11	2	6	5.1	CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	122023	57569	60	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL15766	57569	60	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	CHEMBL45460	57569	60	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/0960-894X(95)00340-Y
	10600128	64884	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	462	10	2	5	6.1	CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	CHEMBL167580	64884	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes	ChEMBL	462	10	2	5	6.1	CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80850-7
	6435820	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00070a015
	CHEMBL422598	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00070a015
	6435820	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL422598	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	6435820	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm960088k
	CHEMBL422598	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm960088k
	6435820	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	CHEMBL422598	171795	6	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils	ChEMBL	563	18	2	6	7.3	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm960248s
	6444688	194099	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	CHEMBL49302	194099	35	None	-	1	Human	8.1	pKi	=	8.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	502	14	2	5	5.9	COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1	10.1016/S0960-894X(01)80999-9
	6852392	24042	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	361	14	3	4	4.0	CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1	10.1021/jm00074a012
	CHEMBL1256923	24042	4	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	361	14	3	4	4.0	CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1	10.1021/jm00074a012
	14977943	121740	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	592	17	3	7	6.5	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL334267	121740	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	592	17	3	7	6.5	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	14977939	103492	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	505	16	1	5	7.4	COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL264197	103492	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	505	16	1	5	7.4	COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	15839736	21412	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	476	9	2	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	10.1016/S0960-894X(01)80999-9
	CHEMBL1205143	21412	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	476	9	2	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	10.1016/S0960-894X(01)80999-9
	CHEMBL58534	21412	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	476	9	2	7	5.0	CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1	10.1016/S0960-894X(01)80999-9
	122023	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80999-9
	CHEMBL15766	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80999-9
	CHEMBL45460	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(01)80999-9
	122023	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80304-2
	CHEMBL15766	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80304-2
	CHEMBL45460	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80304-2
	122023	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL15766	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL45460	57569	60	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	360	10	2	6	3.6	CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	14977955	16348	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	548	17	1	6	7.5	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL112455	16348	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	548	17	1	6	7.5	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	10257351	117419	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	565	19	2	6	7.2	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1	10.1021/jm00046a017
	CHEMBL325773	117419	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	565	19	2	6	7.2	COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1	10.1021/jm00046a017
	9959228	16847	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	549	17	2	6	7.1	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL115362	16847	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	549	17	2	6	7.1	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	9959228	16847	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	549	17	2	6	7.1	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	CHEMBL115362	16847	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes	ChEMBL	549	17	2	6	7.1	COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00074a013
	18963062	21554	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	404	13	2	6	4.8	CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL1206683	21554	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	404	13	2	6	4.8	CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	CHEMBL295799	21554	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay	ChEMBL	404	13	2	6	4.8	CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1	10.1016/S0960-894X(00)80453-9
	10346127	16450	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	507	14	2	6	5.7	COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	CHEMBL112972	16450	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.	ChEMBL	507	14	2	6	5.7	COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1	10.1021/jm00046a017
	15658097	16507	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	401	14	3	4	5.2	CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1	10.1021/jm00074a012
	CHEMBL113351	16507	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	401	14	3	4	5.2	CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1	10.1021/jm00074a012
	44341265	17177	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	263	4	2	2	3.2	Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1	10.1021/jm00074a014
	CHEMBL116278	17177	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4	ChEMBL	263	4	2	2	3.2	Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1	10.1021/jm00074a014
	15658135	21345	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	436	12	2	3	7.6	CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1	10.1021/jm00074a012
	CHEMBL113401	21345	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	436	12	2	3	7.6	CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1	10.1021/jm00074a012
	CHEMBL1204494	21345	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells	ChEMBL	436	12	2	3	7.6	CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1	10.1021/jm00074a012
	None	222976	0	3H-LTB4	3	2	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	336	14	3	3	4.2	CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O	None
	None	222979	0	3H-LTB4	-6	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	14	1	2	5.4	CCCCCC=CCC(=O)C=CC=CCC=CCCCC(=O)O	None
	None	222981	0	3H-LTB4	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	14	1	2	5.4	CCCCCC=CCC=CCC=CC=CC(=O)CCCC(=O)O	None
	None	222982	0	3H-LTB4	-1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	320	14	2	2	5.2	CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O	None
	None	222985	0	3H-LTB4	1	2	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	302	12	1	1	5.7	CCCCCC=CCC=CCC=CCC#CCCCC(=O)O	None
	None	222978	0	3H-LTB4	-57	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	320	14	2	2	5.2	CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O	None
	None	222982	0	3H-LTB4	-1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	320	14	2	2	5.2	CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O	None
	None	222983	0	3H-LTB4	-10	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	320	15	2	2	5.2	C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO	None
	None	222984	0	3H-LTB4	-10	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	320	14	2	2	5.2	CCCCCC=CCC=CC=CC(CC=CCCCC(=O)O)O	None
	None	222987	0	3H-LTB4	-4365	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	473	7	2	3	7.9	CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O	None
	None	222992	0	3H-LTB4	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	332	13	0	3	5.3	CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)OC	None
	132191096	222986	0	3H-LTB4	-1	2	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	352	14	4	4	3.1	CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O	None
	None	222988	0	3H-LTB4	4	2	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	625	25	7	8	2.8	CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N	None
	None	222990	0	3H-LTB4	2	2	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	439	18	4	5	4.3	CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N	None
	None	222980	0	3H-LTB4	218	2	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	361	14	3	4	4.0	CCCCCC=CCC(C=CC1=NC(=CC=C1)CC(CCCCO)O)O	None
	None	222977	0	3H-LTB4	2	2	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	334	13	3	3	3.9	CCC=CCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O	None
	None	222989	0	3H-LTB4	2	2	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	496	20	5	6	3.4	CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N	None
	None	222991	0	3H-LTB4	1	2	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	568	23	6	7	3.7	CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)NC(=O)CCC(C(=O)O)N	None
	2855	10904	104	3H-LTB4	-147	6	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	3322	10904	104	3H-LTB4	-147	6	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	5717	10904	104	3H-LTB4	-147	6	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	CHEMBL603	10904	104	3H-LTB4	-147	6	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	DB00549	10904	104	3H-LTB4	-147	6	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	3325	10676	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	14	3	4	4.0	CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O	10513580
	6449854	10676	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	14	3	4	4.0	CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O	10513580
	3351	9181	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	10	2	6	3.6	CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O	1659282
	35025716	9181	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	10	2	6	3.6	CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O	1659282
	3405	6800	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	320	14	2	2	5.2	CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O	9177352
	5283156	6800	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	320	14	2	2	5.2	CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O	9177352
	CHEMBL1435825	6800	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	320	14	2	2	5.2	CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O	9177352
	177941	8369	50	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	2948	8369	50	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	CHEMBL329123	8369	50	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	DB12850	8369	50	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	544	13	2	5	8.1	CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O	9862783
	114999	10311	21	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	7786309
	6156	10311	21	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	7786309
	CHEMBL14823	10311	21	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	484	13	1	6	5.4	CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O	7786309
	3399	6830	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	15	4	4	3.1	OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	9177352
	5280745	6830	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	15	4	4	3.1	OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	9177352
	CHEMBL1593789	6830	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	15	4	4	3.1	OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	9177352
	6155	7959	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393
	9823886	7959	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393
	CHEMBL301829	7959	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393
	DB13053	7959	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	4	2	3	5.4	O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1	9618393
	6157	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	1332129
	6438358	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	1332129
	CHEMBL422420	9708	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	470	17	2	5	5.6	COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O	1332129
	6154	7421	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	11259574
	6154	7421	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	17170051
	9956189	7421	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	11259574
	9956189	7421	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	466	9	3	4	6.2	Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C	17170051
	2487	9147	36	None	31	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	None
	5280492	9147	36	None	31	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	None
	CHEMBL65061	9147	36	None	31	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	None
	DB12961	9147	36	None	31	2	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	336	14	3	3	4.2	CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O	None
	2855	10904	104	None	-147	6	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	3322	10904	104	None	-147	6	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	5717	10904	104	None	-147	6	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	CHEMBL603	10904	104	None	-147	6	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None
	DB00549	10904	104	None	-147	6	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	None

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