Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 25174150 | 9119 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | 64 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 582 | 18 | 2 | 6 | 7.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099326 | 9119 | None | 0 | Human | Functional | pIC50 | = | 10.2 | 10.2 | 64 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 582 | 18 | 2 | 6 | 7.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25191879 | 9128 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 599 | 18 | 2 | 5 | 8.0 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099335 | 9128 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 599 | 18 | 2 | 5 | 8.0 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25191880 | 9125 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 587 | 18 | 2 | 6 | 7.9 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099332 | 9125 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 587 | 18 | 2 | 6 | 7.9 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192021 | 9116 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 223 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 580 | 18 | 2 | 4 | 8.5 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099323 | 9116 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 223 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 580 | 18 | 2 | 4 | 8.5 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192023 | 8533 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 625 | 18 | 2 | 7 | 7.6 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1094346 | 8533 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 625 | 18 | 2 | 7 | 7.6 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192174 | 9124 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 586 | 18 | 2 | 5 | 8.5 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099331 | 9124 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 586 | 18 | 2 | 5 | 8.5 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 132379 | 111795 | None | 16 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane |
ChEMBL | 453 | 9 | 1 | 3 | 5.4 | CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 | 10.1021/jm00100a034 | ||
| CHEMBL328712 | 111795 | None | 16 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane |
ChEMBL | 453 | 9 | 1 | 3 | 5.4 | CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 | 10.1021/jm00100a034 | ||
| 25192176 | 8534 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 626 | 18 | 2 | 8 | 7.0 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1094347 | 8534 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 626 | 18 | 2 | 8 | 7.0 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192175 | 9127 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 588 | 18 | 2 | 7 | 7.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099334 | 9127 | None | 0 | Human | Functional | pIC50 | = | 9.4 | 9.4 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 588 | 18 | 2 | 7 | 7.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192022 | 3355 | None | 7 | Human | Functional | pIC50 | = | 9.4 | 9.4 | 21 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| 6158 | 3355 | None | 7 | Human | Functional | pIC50 | = | 9.4 | 9.4 | 21 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1098560 | 3355 | None | 7 | Human | Functional | pIC50 | = | 9.4 | 9.4 | 21 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| 23501721 | 9123 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 316 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 581 | 18 | 2 | 5 | 7.9 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099330 | 9123 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 316 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 581 | 18 | 2 | 5 | 7.9 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192325 | 9126 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 621 | 18 | 2 | 6 | 8.6 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099333 | 9126 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 621 | 18 | 2 | 6 | 8.6 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192326 | 9032 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 592 | 18 | 2 | 6 | 8.6 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1098550 | 9032 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 592 | 18 | 2 | 6 | 8.6 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192327 | 9130 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 624 | 18 | 2 | 6 | 8.2 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1099337 | 9130 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 624 | 18 | 2 | 6 | 8.2 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 25192468 | 8536 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 642 | 18 | 2 | 6 | 8.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1094349 | 8536 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | - | 1 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 642 | 18 | 2 | 6 | 8.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 132379 | 111795 | None | 16 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes. |
ChEMBL | 453 | 9 | 1 | 3 | 5.4 | CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 | 10.1021/jm00100a034 | ||
| CHEMBL328712 | 111795 | None | 16 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes. |
ChEMBL | 453 | 9 | 1 | 3 | 5.4 | CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 | 10.1021/jm00100a034 | ||
| 25192471 | 8535 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 15 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 642 | 18 | 2 | 6 | 8.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1094348 | 8535 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 15 | 2 | Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins |
ChEMBL | 642 | 18 | 2 | 6 | 8.3 | O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O | 10.1021/jm1001919 | ||
| 10319829 | 26126 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 417 | 11 | 1 | 3 | 6.9 | CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O | 10.1021/jm00101a008 | ||
| CHEMBL135612 | 26126 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 417 | 11 | 1 | 3 | 6.9 | CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O | 10.1021/jm00101a008 | ||
| 10341135 | 29396 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 403 | 10 | 1 | 3 | 6.5 | CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O | 10.1021/jm00101a008 | ||
| CHEMBL138380 | 29396 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 403 | 10 | 1 | 3 | 6.5 | CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O | 10.1021/jm00101a008 | ||
| 10047140 | 27615 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 409 | 9 | 1 | 3 | 6.3 | CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O | 10.1021/jm00101a008 | ||
| CHEMBL136960 | 27615 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 409 | 9 | 1 | 3 | 6.3 | CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O | 10.1021/jm00101a008 | ||
| 14946858 | 29169 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 375 | 9 | 0 | 4 | 5.5 | COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| CHEMBL138174 | 29169 | None | 0 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 375 | 9 | 0 | 4 | 5.5 | COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| 6444688 | 187426 | None | 30 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 502 | 14 | 2 | 5 | 5.9 | COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 | 10.1021/jm00101a008 | ||
| CHEMBL49302 | 187426 | None | 30 | Human | Functional | pIC50 | = | 6 | 6.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 502 | 14 | 2 | 5 | 5.9 | COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 | 10.1021/jm00101a008 | ||
| 10071290 | 28108 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 429 | 9 | 1 | 3 | 6.5 | O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| CHEMBL137303 | 28108 | None | 0 | Human | Functional | pIC50 | = | 5 | 5.0 | - | 1 | Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes |
ChEMBL | 429 | 9 | 1 | 3 | 6.5 | O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| 25192022 | 3355 | None | 7 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 21 | 2 | Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| 6158 | 3355 | None | 7 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 21 | 2 | Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
| CHEMBL1098560 | 3355 | None | 7 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 21 | 2 | Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge |
ChEMBL | 630 | 18 | 2 | 7 | 8.3 | OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O | 10.1021/jm1001919 | ||
Showing 1 to 50 of 180 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 44379678 | 165017 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 527 | 14 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| CHEMBL422388 | 165017 | None | 0 | Human | Binding | pIC50 | = | 10 | 10.0 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 527 | 14 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| 44379453 | 58102 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 513 | 13 | 1 | 6 | 4.9 | CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| CHEMBL167350 | 58102 | None | 0 | Human | Binding | pIC50 | = | 9.8 | 9.8 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 513 | 13 | 1 | 6 | 4.9 | CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| 15817161 | 58152 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 499 | 13 | 2 | 6 | 4.6 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| CHEMBL167804 | 58152 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 499 | 13 | 2 | 6 | 4.6 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| 9865985 | 28681 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 405 | 9 | 1 | 5 | 5.2 | O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| CHEMBL137759 | 28681 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 405 | 9 | 1 | 5 | 5.2 | O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| 114999 | 3538 | None | 17 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 484 | 13 | 1 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O | 10.1016/S0960-894X(01)80853-2 | ||
| 6156 | 3538 | None | 17 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 484 | 13 | 1 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O | 10.1016/S0960-894X(01)80853-2 | ||
| CHEMBL14823 | 3538 | None | 17 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 1 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 484 | 13 | 1 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O | 10.1016/S0960-894X(01)80853-2 | ||
| 204058 | 163554 | None | 7 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding |
ChEMBL | 539 | 15 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 | 10.1021/jm960088k | ||
| CHEMBL419948 | 163554 | None | 7 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 1 | Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding |
ChEMBL | 539 | 15 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 | 10.1021/jm960088k | ||
| 196905 | 111694 | None | 3 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding |
ChEMBL | 539 | 15 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 | 10.1021/jm960088k | ||
| CHEMBL328492 | 111694 | None | 3 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding |
ChEMBL | 539 | 15 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 | 10.1021/jm960088k | ||
| 2487 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1016/S0960-894X(01)80999-9 | ||
| 5280492 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1016/S0960-894X(01)80999-9 | ||
| CHEMBL65061 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1016/S0960-894X(01)80999-9 | ||
| DB12961 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1016/S0960-894X(01)80999-9 | ||
| 6444688 | 187426 | None | 30 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 37 | 2 | Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4 |
ChEMBL | 502 | 14 | 2 | 5 | 5.9 | COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 | 10.1021/jm00064a006 | ||
| CHEMBL49302 | 187426 | None | 30 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 37 | 2 | Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4 |
ChEMBL | 502 | 14 | 2 | 5 | 5.9 | COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 | 10.1021/jm00064a006 | ||
| 2487 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1021/jm00172a020 | ||
| 5280492 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1021/jm00172a020 | ||
| CHEMBL65061 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1021/jm00172a020 | ||
| DB12961 | 2368 | None | 25 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 31 | 2 | Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils |
ChEMBL | 336 | 14 | 3 | 3 | 4.2 | CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O | 10.1021/jm00172a020 | ||
| 11799000 | 17175 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane |
ChEMBL | 482 | 9 | 1 | 4 | 5.1 | CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 | 10.1021/jm950699x | ||
| CHEMBL125611 | 17175 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane |
ChEMBL | 482 | 9 | 1 | 4 | 5.1 | CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 | 10.1021/jm950699x | ||
| 10385899 | 27415 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes |
ChEMBL | 393 | 9 | 1 | 4 | 5.6 | COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 | 10.1021/jm00101a007 | ||
| CHEMBL136805 | 27415 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes |
ChEMBL | 393 | 9 | 1 | 4 | 5.6 | COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 | 10.1021/jm00101a007 | ||
| 9999755 | 26580 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 379 | 9 | 1 | 3 | 5.6 | O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| CHEMBL136094 | 26580 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 379 | 9 | 1 | 3 | 5.6 | O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| 44357534 | 26748 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 385 | 9 | 0 | 6 | 4.7 | c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 | 10.1021/jm00101a008 | ||
| CHEMBL136243 | 26748 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 385 | 9 | 0 | 6 | 4.7 | c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 | 10.1021/jm00101a008 | ||
| 10071290 | 28108 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 429 | 9 | 1 | 3 | 6.5 | O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| CHEMBL137303 | 28108 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes. |
ChEMBL | 429 | 9 | 1 | 3 | 6.5 | O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| 196905 | 111694 | None | 3 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 539 | 15 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| CHEMBL328492 | 111694 | None | 3 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor |
ChEMBL | 539 | 15 | 2 | 6 | 5.4 | CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 | 10.1016/S0960-894X(01)80853-2 | ||
| 11756030 | 58777 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor |
ChEMBL | 509 | 13 | 1 | 7 | 5.9 | CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1021/jm00006a002 | ||
| CHEMBL168658 | 58777 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor |
ChEMBL | 509 | 13 | 1 | 7 | 5.9 | CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 | 10.1021/jm00006a002 | ||
| 14946858 | 29169 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes. |
ChEMBL | 375 | 9 | 0 | 4 | 5.5 | COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| CHEMBL138174 | 29169 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes. |
ChEMBL | 375 | 9 | 0 | 4 | 5.5 | COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 | 10.1021/jm00101a008 | ||
| 10407251 | 119145 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes |
ChEMBL | 377 | 8 | 1 | 3 | 5.9 | Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 | 10.1021/jm00101a007 | ||
| CHEMBL342688 | 119145 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes |
ChEMBL | 377 | 8 | 1 | 3 | 5.9 | Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 | 10.1021/jm00101a007 | ||
| 15666577 | 9203 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M |
ChEMBL | 330 | 11 | 1 | 2 | 5.5 | O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 | 10.1021/jm00095a011 | ||
| CHEMBL110402 | 9203 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M |
ChEMBL | 330 | 11 | 1 | 2 | 5.5 | O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 | 10.1021/jm00095a011 | ||
| 15666579 | 5629 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M |
ChEMBL | 364 | 11 | 1 | 2 | 6.2 | O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 | 10.1021/jm00095a011 | ||
| CHEMBL107760 | 5629 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M |
ChEMBL | 364 | 11 | 1 | 2 | 6.2 | O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 | 10.1021/jm00095a011 | ||
| 15666578 | 7906 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M |
ChEMBL | 364 | 11 | 1 | 2 | 6.2 | O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 | 10.1021/jm00095a011 | ||
| CHEMBL109015 | 7906 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M |
ChEMBL | 364 | 11 | 1 | 2 | 6.2 | O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 | 10.1021/jm00095a011 | ||
| 15666603 | 8140 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M |
ChEMBL | 330 | 11 | 1 | 2 | 5.5 | O=C(O)CCCCCCc1sccc1CCCc1ccccc1 | 10.1021/jm00095a011 | ||
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