GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	9827294	80640	3	None	-	1	Human	8.0	pEC50	=	8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL2018953	80640	3	None	-	1	Human	8.0	pEC50	=	8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.ejmech.2016.02.058
	127046612	146528	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798452	146528	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127046614	146704	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799578	146704	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	127047356	146412	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	146412	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	44288958	175506	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL43698	175506	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	127047440	146385	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	542	7	2	8	4.4	COc1cc2nc(N3CCC(N(C)C(=O)[C@H]4CCCN4)CC3)nc(Nc3ccc(Cl)cc3F)c2cc1OC	10.1016/j.ejmech.2016.02.058
	CHEMBL3797462	146385	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	542	7	2	8	4.4	COc1cc2nc(N3CCC(N(C)C(=O)[C@H]4CCCN4)CC3)nc(Nc3ccc(Cl)cc3F)c2cc1OC	10.1016/j.ejmech.2016.02.058
	127047612	146670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799393	146670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Induction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometryInduction of CCR4 internalisation in human HUT78 cells after 30 mins by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	44288959	172086	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42334	172086	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4Inhibition of MDC-stimulated chemotaxis in transfected murine cell line expressing human chemokine receptor 4	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	10238794	169614	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	473	7	2	6	4.3	O=S(=O)(Nc1ncc(Cl)nc1OCc1ccccc1CO)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172769	169614	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	473	7	2	6	4.3	O=S(=O)(Nc1ncc(Cl)nc1OCc1ccccc1CO)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10195057	169276	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	444	6	1	6	4.2	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4167445	169276	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	444	6	1	6	4.2	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	23585443	7330	12	None	3	3	Mouse	9.0	pIC50	=	9	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	7330	12	None	3	3	Mouse	9.0	pIC50	=	9	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	7330	12	None	3	3	Mouse	9.0	pIC50	=	9	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	145959198	168952	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	369	4	1	5	2.9	COc1nc(F)c(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4162364	168952	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	369	4	1	5	2.9	COc1nc(F)c(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10308720	7333	42	None	2	3	Mouse	8.0	pIC50	=	8	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	7333	42	None	2	3	Mouse	8.0	pIC50	=	8	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	7333	42	None	2	3	Mouse	8.0	pIC50	=	8	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	10309893	169467	2	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4170431	169467	2	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	11525206	142006	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Calcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPRCalcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPR	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL372399	142006	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Calcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPRCalcium mobilization mediated by CCR4 receptor in CEMS529 cells by FLIPR	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44581043	194613	0	None	1	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496152	194613	0	None	1	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581068	194703	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496787	194703	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	25212472	199425	0	None	-2	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL521737	199425	0	None	-2	2	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	59456023	93931	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	516	8	2	7	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)=O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326612	93931	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	516	8	2	7	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)=O)cccc32)c1	10.1021/jm301572h
	59456042	93933	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	532	8	3	7	4.5	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)(C)O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326614	93933	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	532	8	3	7	4.5	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)(C)O)cccc32)c1	10.1021/jm301572h
	59456012	93934	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326615	93934	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	71584536	93948	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccnc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326628	93948	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccnc(CNC(C)=O)c1	10.1021/jm301572h
	59168189	169206	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1	10.1021/acsmedchemlett.7b00315
	CHEMBL4166246	169206	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1	10.1021/acsmedchemlett.7b00315
	118706823	119753	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	5	2	5	4.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL3310832	119753	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	5	2	5	4.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(C)C	10.1016/j.bmc.2014.05.021
	10309983	168892	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	417	4	1	6	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4161268	168892	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	417	4	1	6	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/acsmedchemlett.7b00315
	145949792	169485	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	425	5	1	6	3.8	COc1nc(Br)cnc1NS(=O)(=O)c1sccc1-c1ccccc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4170786	169485	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	425	5	1	6	3.8	COc1nc(Br)cnc1NS(=O)(=O)c1sccc1-c1ccccc1	10.1021/acsmedchemlett.7b00315
	137642528	165043	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1ccc2c(cnn2C)c1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	CHEMBL4088688	165043	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1ccc2c(cnn2C)c1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	137659242	165946	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	458	6	2	9	2.3	COc1nn(C)c2nc(NC3COC3)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4098333	165946	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	458	6	2	9	2.3	COc1nn(C)c2nc(NC3COC3)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	145955299	169368	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	368	4	1	6	2.6	COc1nc(Cl)cnc1NS(=O)(=O)c1ccnc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4168920	169368	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	368	4	1	6	2.6	COc1nc(Cl)cnc1NS(=O)(=O)c1ccnc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	155520262	177247	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	578	7	0	8	5.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(C)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4448901	177247	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	578	7	0	8	5.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(C)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	71461546	91116	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	640	11	2	5	6.3	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmc.2012.03.069
	CHEMBL2216810	91116	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	640	11	2	5	6.3	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmc.2012.03.069
	25141301	192667	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	192667	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	192667	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL486840	192667	0	None	1	2	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	118706824	119754	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	443	5	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1COC1	10.1016/j.bmc.2014.05.021
	CHEMBL3310833	119754	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	443	5	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1COC1	10.1016/j.bmc.2014.05.021
	59456067	80656	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018968	80656	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	136116031	93577	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	CHEMBL2321924	93577	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	59456019	93950	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326630	93950	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	10195081	168939	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	445	6	1	7	3.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cncnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4162097	168939	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	445	6	1	7	3.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cncnc1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10309206	169185	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4165939	169185	5	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	59168214	169816	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	6	1	6	3.0	CCOc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1	10.1021/acsmedchemlett.7b00315
	CHEMBL4175972	169816	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	6	1	6	3.0	CCOc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1	10.1021/acsmedchemlett.7b00315
	134210781	184987	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(C4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4649666	184987	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(C4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	71584537	93949	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)n1	10.1021/jm301572h
	CHEMBL2326629	93949	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)n1	10.1021/jm301572h
	10150948	168754	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4159115	168754	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1Cl	10.1021/acsmedchemlett.7b00315
	10287210	169870	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4176859	169870	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)cc1	10.1021/acsmedchemlett.7b00315
	137652824	165540	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	357	3	1	6	2.5	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4093994	165540	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	357	3	1	6	2.5	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	10126022	169553	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1ccsc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4171873	169553	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1ccsc1	10.1021/acsmedchemlett.7b00315
	137632634	163171	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	356	3	1	5	3.1	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ccnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4066451	163171	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	356	3	1	5	3.1	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ccnc21	10.1016/j.bmc.2017.07.052
	155543648	179972	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(N3CCC(N4CCCCC4)C(C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4522547	179972	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(N3CCC(N4CCCCC4)C(C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	70685474	80653	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	518	8	1	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN(C)C(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018965	80653	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	518	8	1	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN(C)C(C)=O)c1	10.1016/j.bmcl.2012.02.104
	44561334	183002	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	CHEMBL459464	183002	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	44561260	195823	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	384	6	2	6	5.1	COc1cc2nc(NC3CCCC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL509396	195823	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	384	6	2	6	5.1	COc1cc2nc(NC3CCCC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44562238	193534	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	524	8	1	8	5.0	COc1cc2nc(N3CCCN(CCN4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488855	193534	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	524	8	1	8	5.0	COc1cc2nc(N3CCCN(CCN4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	192667	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	192667	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	193216	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	193216	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	192667	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL486840	192667	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	16724339	193216	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL487635	193216	0	None	-1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156013953	183986	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	418	5	0	6	4.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(CN(C)C)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4635359	183986	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	418	5	0	6	4.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC(CN(C)C)C3)cnc12	10.1021/acs.jmedchem.0c00988
	10416	8660	30	None	309	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	46861584	8660	30	None	309	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	CHEMBL2018969	8660	30	None	309	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	44288958	175506	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmc.2012.03.069
	CHEMBL43698	175506	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmc.2012.03.069
	25141190	7929	28	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	9478	7929	28	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	CHEMBL508207	7929	28	None	-1	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	44581102	194551	0	None	1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495736	194551	0	None	1	2	Mouse	6.9	pIC50	=	6.9	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156017568	184600	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	494	5	0	8	4.3	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4643839	184600	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	494	5	0	8	4.3	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	59455988	93940	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	CHEMBL2326620	93940	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	59456014	93941	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	CHEMBL2326621	93941	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	59456103	93942	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	CHEMBL2326622	93942	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	58054368	93944	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326624	93944	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	59456058	93953	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326633	93953	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	56849395	93965	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326926	93965	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	10308720	7333	42	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	7333	42	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	7333	42	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	10308963	168964	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(F)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4162555	168964	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(F)c1Cl	10.1021/acsmedchemlett.7b00315
	145951541	169489	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	409	6	1	5	4.3	CC(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4170833	169489	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	409	6	1	5	4.3	CC(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44562237	193507	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	510	8	1	8	4.7	COc1cc2nc(N3CCCN(CCN4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488691	193507	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	510	8	1	8	4.7	COc1cc2nc(N3CCCN(CCN4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	71525425	139590	0	None	-446	5	Human	5.8	pIC50	=	5.8	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	509	8	3	9	2.7	Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	CHEMBL3701196	139590	0	None	-446	5	Human	5.8	pIC50	=	5.8	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	509	8	3	9	2.7	Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	59455992	80644	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018957	80644	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	23585443	7330	12	None	-16	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	7330	12	None	-16	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	7330	12	None	-16	3	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	71584535	93947	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cc(CNC(C)=O)ccn1	10.1021/jm301572h
	CHEMBL2326627	93947	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	505	8	2	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cc(CNC(C)=O)ccn1	10.1021/jm301572h
	137633709	163398	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	373	4	2	6	2.5	COc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4069103	163398	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	373	4	2	6	2.5	COc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	145955692	169274	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4167390	169274	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	4	1	5	2.7	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1Cl	10.1021/acsmedchemlett.7b00315
	145971718	169847	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	453	7	1	5	4.5	CCCCOc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4176441	169847	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	453	7	1	5	4.5	CCCCOc1nc(Br)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	118706827	119757	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	461	7	4	7	2.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(CO)CO	10.1016/j.bmc.2014.05.021
	CHEMBL3310836	119757	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	461	7	4	7	2.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C(CO)CO	10.1016/j.bmc.2014.05.021
	137643503	165187	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	3	3	6	2.2	O=S(=O)(Nc1ncnc2[nH]nc(O)c12)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	CHEMBL4090166	165187	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	3	3	6	2.2	O=S(=O)(Nc1ncnc2[nH]nc(O)c12)c1cccc(Cl)c1Cl	10.1016/j.bmc.2017.07.052
	155561858	182534	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4583503	182534	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134325276	182254	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4577319	182254	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134211225	184704	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4645325	184704	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	25141190	7929	28	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	9478	7929	28	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	CHEMBL508207	7929	28	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	25141190	7929	28	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	9478	7929	28	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	CHEMBL508207	7929	28	None	-1	2	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	44561294	179759	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	481	7	1	7	5.6	COc1cc2nc(N3CCC(N(C)C4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL451783	179759	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	481	7	1	7	5.6	COc1cc2nc(N3CCC(N(C)C4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44581121	195042	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	553	10	2	8	5.0	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL499852	195042	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	553	10	2	8	5.0	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	16724339	193216	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	193216	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	193216	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL487635	193216	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	25212379	194641	1	None	2	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496356	194641	1	None	2	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	16724339	193216	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL487635	193216	0	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	25212472	199425	0	None	2	2	Mouse	7.7	pIC50	=	7.7	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL521737	199425	0	None	2	2	Mouse	7.7	pIC50	=	7.7	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	59455975	93932	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326613	93932	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	71583488	93935	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	CHEMBL2326616	93935	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	11244702	169112	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	339	4	1	6	2.7	COc1nccnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4164738	169112	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	339	4	1	6	2.7	COc1nccnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	59168158	169330	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C	10.1021/acsmedchemlett.7b00315
	CHEMBL4168237	169330	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C	10.1021/acsmedchemlett.7b00315
	10215932	79902	1	None	-22	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at CCR4 in human primary Th2 cells by chemotaxis assayAntagonist activity at CCR4 in human primary Th2 cells by chemotaxis assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL2011441	79902	1	None	-22	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at CCR4 in human primary Th2 cells by chemotaxis assayAntagonist activity at CCR4 in human primary Th2 cells by chemotaxis assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	118706818	119749	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C	10.1016/j.bmc.2014.05.021
	CHEMBL3310827	119749	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C	10.1016/j.bmc.2014.05.021
	118706829	119759	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	484	5	2	6	2.8	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CN(C(C)=O)C1	10.1016/j.bmc.2014.05.021
	CHEMBL3310838	119759	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	484	5	2	6	2.8	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CN(C(C)=O)C1	10.1016/j.bmc.2014.05.021
	137643926	165004	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	6	2	8	2.0	COc1nn(CC(=O)O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4088207	165004	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	6	2	8	2.0	COc1nn(CC(=O)O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	10194488	168957	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1021/acsmedchemlett.7b00315
	CHEMBL4162503	168957	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1021/acsmedchemlett.7b00315
	10194274	169162	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	1	6	3.2	CCOc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4165500	169162	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	1	6	3.2	CCOc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	118706820	119751	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	415	4	1	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)n(C)c(=O)n2C	10.1016/j.bmc.2014.05.021
	CHEMBL3310829	119751	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	415	4	1	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)n(C)c(=O)n2C	10.1016/j.bmc.2014.05.021
	118706826	119756	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	458	7	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CCN(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL3310835	119756	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	458	7	2	6	3.0	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CCN(C)C	10.1016/j.bmc.2014.05.021
	137661320	165860	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2ccccc21	10.1016/j.bmc.2017.07.052
	CHEMBL4097341	165860	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2ccccc21	10.1016/j.bmc.2017.07.052
	118706819	119750	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2[nH]c(=O)n(C)c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310828	119750	0	None	-	1	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	401	4	2	5	3.0	COc1cc2[nH]c(=O)n(C)c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	23585443	7330	12	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	7330	12	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	7330	12	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59168181	168825	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	391	5	1	5	3.3	C#CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160218	168825	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	391	5	1	5	3.3	C#CCOc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	16724339	193216	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	193216	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	193216	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL487635	193216	0	None	1	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44561335	183004	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	393	4	1	5	4.8	c1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	CHEMBL459465	183004	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	393	4	1	5	4.8	c1ccc2c(NC3CCCCCC3)nc(N3CCC(N4CCCC4)CC3)nc2c1	10.1016/j.bmc.2008.05.036
	44561588	201332	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL529664	201332	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	134210933	184285	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639600	184285	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134225255	184104	10	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	184104	10	None	1	2	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134211098	184823	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647117	184823	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	58054516	80646	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	CHEMBL2018959	80646	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	44562156	193508	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488704	193508	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44561217	195895	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL510375	195895	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	134324821	177881	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.5	CC1CN(c2cnc3c(C(N)=O)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4457732	177881	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	515	5	1	7	4.5	CC1CN(c2cnc3c(C(N)=O)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	134324770	177722	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	CHEMBL4455432	177722	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	134225247	184442	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641595	184442	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	134325106	178030	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4460062	178030	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	25212379	194641	1	None	2	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496356	194641	1	None	2	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581044	200227	0	None	-3	2	Mouse	6.6	pIC50	=	6.6	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	CHEMBL526474	200227	0	None	-3	2	Mouse	6.6	pIC50	=	6.6	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	134325169	179188	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	CC1CN(c2cnc3cnn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4476671	179188	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	CC1CN(c2cnc3cnn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	134211185	183932	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4634054	183932	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	25141301	192667	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	192667	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	25141301	192667	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL486840	192667	0	None	1	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156010350	183861	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633133	183861	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44562155	193410	0	None	19	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488018	193410	0	None	19	2	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	102143549	119760	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310839	119760	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054475	93943	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326623	93943	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	58597374	169359	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	363	5	2	6	2.1	COc1nc(CO)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4168775	169359	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	363	5	2	6	2.1	COc1nc(CO)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	134335265	181755	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	497	4	0	7	5.3	CC1CN(c2cnc3c(C#N)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4566241	181755	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	497	4	0	7	5.3	CC1CN(c2cnc3c(C#N)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	71583704	93946	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	9	2	8	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC2COC2)c1	10.1021/jm301572h
	CHEMBL2326626	93946	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	518	9	2	8	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC2COC2)c1	10.1021/jm301572h
	71583039	93966	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	474	7	2	6	4.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3ccccc32)c1	10.1021/jm301572h
	CHEMBL2326927	93966	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	474	7	2	6	4.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3ccccc32)c1	10.1021/jm301572h
	137647817	164336	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	429	5	1	8	2.5	COc1nn(C2COC2)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4080352	164336	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	429	5	1	8	2.5	COc1nn(C2COC2)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137653647	165823	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	2.9	CCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4096860	165823	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	2.9	CCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	137661613	166001	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	415	5	1	7	3.5	COc1nn(C(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4098813	166001	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	415	5	1	7	3.5	COc1nn(C(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	155518637	177101	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.2	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(N3CCC(N4CCCCC4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	CHEMBL4446924	177101	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.2	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(N3CCC(N4CCCCC4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	44561137	193498	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL488640	193498	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	134325016	181432	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	CHEMBL4558456	181432	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	59456051	80655	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018967	80655	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	142450222	176453	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	484	4	1	6	4.5	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(C3=CCN(C(=O)[C@H]4CCCCN4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	CHEMBL4437594	176453	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	484	4	1	6	4.5	CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(C3=CCN(C(=O)[C@H]4CCCCN4)CC3)nc21	10.1021/acs.jmedchem.9b00506
	156010372	183887	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4633494	183887	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44562191	193535	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488857	193535	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	58834906	99419	0	None	-467	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	604	8	1	6	6.2	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1	10.1021/jm401101p
	CHEMBL2435853	99419	0	None	-467	2	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	604	8	1	6	6.2	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2cccc(Cl)c2)CC1	10.1021/jm401101p
	134210845	184828	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647188	184828	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44430312	94035	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL233046	94035	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	9959269	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL2018954	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	9959269	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	CHEMBL2018954	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	9959269	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2017.07.052
	9959269	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	CHEMBL2018954	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2017.07.052
	CHEMBL2018954	80641	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	23585443	7330	12	None	-16	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	7330	12	None	-16	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	7330	12	None	-16	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in HEK cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59168106	168863	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	2	6	2.7	COc1nc(CO)c(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160846	168863	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	397	5	2	6	2.7	COc1nc(CO)c(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	23585446	169635	1	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1ncc(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4173046	169635	1	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1ncc(F)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	59168165	169770	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	521	6	1	5	5.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccc(Br)c1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4175323	169770	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	521	6	1	5	5.6	O=S(=O)(Nc1ncc(Cl)nc1OCc1cccc(Br)c1)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	25212472	199425	0	None	-2	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL521737	199425	0	None	-2	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	7	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.11.020
	134210626	184084	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4636749	184084	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44562189	193354	0	None	7	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487835	193354	0	None	7	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44561333	196657	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2c1	10.1016/j.bmc.2008.05.036
	CHEMBL516936	196657	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	423	5	1	6	4.8	COc1ccc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2c1	10.1016/j.bmc.2008.05.036
	10308720	7333	42	None	-4	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	7333	42	None	-4	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	7333	42	None	-4	3	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilizationAntagonist activity at human CCR4 expressed in CHO cells coexpressing CD4+ assessed as inhibition of CCL22 induced Ca2+ mobilization	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59456102	80652	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018964	80652	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	59456102	80652	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2018964	80652	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	58054384	93926	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	CHEMBL2326608	93926	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	71583489	93936	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCO2)c1	10.1021/jm301572h
	CHEMBL2326617	93936	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	546	9	2	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCO2)c1	10.1021/jm301572h
	59456010	93938	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	CHEMBL2326619	93938	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	118706817	119748	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310826	119748	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	23585443	7330	12	None	-16	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	7330	12	None	-16	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	7330	12	None	-16	3	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	59456021	93929	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	7	2	7	4.1	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C#N)cccc32)c1	10.1021/jm301572h
	CHEMBL2326610	93929	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	7	2	7	4.1	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C#N)cccc32)c1	10.1021/jm301572h
	137632888	163312	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.6	COCCn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4068045	163312	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.6	COCCn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	137644457	165094	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	402	4	2	8	2.1	COc1nn(C)c2nc(N)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4089151	165094	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	402	4	2	8	2.1	COc1nn(C)c2nc(N)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137632974	163126	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	3.3	COc1nn(C)c2nc(NC(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4065904	163126	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	3.3	COc1nn(C)c2nc(NC(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137652382	164173	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)cccc21	10.1016/j.bmc.2017.07.052
	CHEMBL4078359	164173	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	355	3	1	4	3.7	Cn1ncc2c(NS(=O)(=O)c3cccc(Cl)c3Cl)cccc21	10.1016/j.bmc.2017.07.052
	10173173	169026	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)ccc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4163571	169026	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)ccc1Cl	10.1021/acsmedchemlett.7b00315
	145950145	169660	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	279	6	1	5	1.7	CCCCS(=O)(=O)Nc1ncc(Cl)nc1OC	10.1021/acsmedchemlett.7b00315
	CHEMBL4173424	169660	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	279	6	1	5	1.7	CCCCS(=O)(=O)Nc1ncc(Cl)nc1OC	10.1021/acsmedchemlett.7b00315
	145950218	169744	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	399	4	1	6	3.5	CSc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4174872	169744	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	399	4	1	6	3.5	CSc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	134325076	178964	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4473604	178964	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134325041	181811	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4567398	181811	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44561172	180489	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	485	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCC(F)CC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL453594	180489	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	485	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCC(F)CC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	70685473	80638	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018951	80638	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	44562189	193354	0	None	7	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487835	193354	0	None	7	2	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	70681287	80648	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	CHEMBL2018960	80648	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	134335394	179121	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	CHEMBL4475665	179121	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	156018849	184686	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4645037	184686	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134335393	176891	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4443688	176891	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44562192	192556	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486656	192556	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	134211221	184467	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4641873	184467	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	134325003	182161	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4575089	182161	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	156015374	184394	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4640909	184394	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	16041411	99351	0	None	-4168	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	572	8	1	6	5.6	O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1	10.1021/jm401101p
	CHEMBL2434978	99351	0	None	-4168	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	572	8	1	6	5.6	O=C(O)c1ccc(Sc2ccc(CN3CCC(N4C(=O)N(C5CCOCC5)C[C@H]4c4ccccc4)CC3)cn2)cc1	10.1021/jm401101p
	11525206	142006	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of chemotaxis of murine CCR4 transfected L1.2 cellsInhibition of chemotaxis of murine CCR4 transfected L1.2 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL372399	142006	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of chemotaxis of murine CCR4 transfected L1.2 cellsInhibition of chemotaxis of murine CCR4 transfected L1.2 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	155557193	181304	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	CHEMBL4555534	181304	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	70689680	80642	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018955	80642	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	25141190	7929	28	None	1	2	Mouse	7.4	pIC50	=	7.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	9478	7929	28	None	1	2	Mouse	7.4	pIC50	=	7.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	CHEMBL508207	7929	28	None	1	2	Mouse	7.4	pIC50	=	7.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.11.020
	10416	8660	30	None	309	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	46861584	8660	30	None	309	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	CHEMBL2018969	8660	30	None	309	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	59456111	93937	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	CHEMBL2326618	93937	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	59456026	93951	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326631	93951	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59455990	93952	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326632	93952	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	10288569	168819	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	461	4	1	6	3.5	COc1nc(Br)cnc1NS(=O)(=O)c1sc(Cl)cc1Br	10.1021/acsmedchemlett.7b00315
	CHEMBL4160139	168819	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	461	4	1	6	3.5	COc1nc(Br)cnc1NS(=O)(=O)c1sc(Cl)cc1Br	10.1021/acsmedchemlett.7b00315
	10287192	168835	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	5	2	6	2.4	COc1nc(CO)c(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160463	168835	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	377	5	2	6	2.4	COc1nc(CO)c(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	10193586	169601	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(C)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172568	169601	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1nc(C)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44581103	194552	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495737	194552	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	118706828	119758	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	442	5	3	6	2.6	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CNC1	10.1016/j.bmc.2014.05.021
	CHEMBL3310837	119758	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	442	5	3	6	2.6	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2C1CNC1	10.1016/j.bmc.2014.05.021
	56848673	93962	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326923	93962	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	56848670	93964	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326925	93964	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	576	9	3	7	4.6	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	118706825	119755	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	6	2	5	3.9	CCCn1c(=O)[nH]c2cc(NS(=O)(=O)c3cccc(Cl)c3Cl)c(OC)cc21	10.1016/j.bmc.2014.05.021
	CHEMBL3310834	119755	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	429	6	2	5	3.9	CCCn1c(=O)[nH]c2cc(NS(=O)(=O)c3cccc(Cl)c3Cl)c(OC)cc21	10.1016/j.bmc.2014.05.021
	137656805	166505	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	7	1	8	2.5	COc1nn(CCN(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4104585	166505	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	7	1	8	2.5	COc1nn(CCN(C)C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	10417	7855	9	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	134324842	7855	9	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	CHEMBL4459231	7855	9	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	155541406	179774	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4518040	179774	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	58054487	80651	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018963	80651	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	134211126	184348	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4640439	184348	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	155531126	178386	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4465359	178386	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44581043	194613	0	None	-1	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496152	194613	0	None	-1	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44562191	193535	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488857	193535	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	485	9	2	8	4.3	COc1cc2nc(N3CCC(N(C)CCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44581042	194612	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496151	194612	0	None	-6	2	Mouse	6.4	pIC50	=	6.4	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581102	194551	0	None	-1	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495736	194551	0	None	-1	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	71555361	140102	0	None	-234	5	Human	6.4	pIC50	=	6.4	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	564	8	3	10	2.4	Cc1ccc([C@H](Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	CHEMBL3704573	140102	0	None	-234	5	Human	6.4	pIC50	=	6.4	Functional	FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50).	ChEMBL	564	8	3	10	2.4	Cc1ccc([C@H](Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2(C)COC2)o1	nan
	134210778	184481	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4642090	184481	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	118706821	119752	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	444	6	3	6	1.9	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CC(N)=O	10.1016/j.bmc.2014.05.021
	CHEMBL3310830	119752	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	444	6	3	6	1.9	COc1cc2c(cc1NS(=O)(=O)c1cccc(Cl)c1Cl)[nH]c(=O)n2CC(N)=O	10.1016/j.bmc.2014.05.021
	134336138	184274	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639418	184274	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134324973	177166	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4447900	177166	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	70693879	80196	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2016602	80196	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	44581042	194612	0	None	6	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496151	194612	0	None	6	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44561561	185780	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL470962	185780	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	10215932	79902	1	None	22	2	Mouse	8.3	pIC50	=	8.3	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL2011441	79902	1	None	22	2	Mouse	8.3	pIC50	=	8.3	Functional	Antagonist activity at mouse CCR4Antagonist activity at mouse CCR4	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	9827294	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	CHEMBL2018953	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	9827294	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018953	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	9827294	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2017.07.052
	9827294	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	CHEMBL2018953	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2017.07.052
	CHEMBL2018953	80640	3	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	118706831	119762	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310841	119762	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	56848674	93963	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	542	9	3	7	3.9	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326924	93963	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	542	9	3	7	3.9	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59168115	169075	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1ncc(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4164247	169075	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	347	4	1	5	2.9	COc1ncc(C)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44430315	18638	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL1182360	18638	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233047	18638	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	11223594	77859	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195298	77859	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)Inhibitory concentration in CCR4-transfected murine pre-B L1.2 cells (chemotaxis assay)	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	10308720	7333	42	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	7333	42	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	7333	42	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL17 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	10308720	7333	42	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	7333	42	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	7333	42	None	-4	3	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxisAntagonist activity at human CCR4 expressed in Th2 cells coexpressing CD45RA+ assessed as inhibition of CCL22 induced chemotaxis	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	137638825	163649	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	1.4	COc1nn(CC(N)=O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4071815	163649	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	6	2	8	1.4	COc1nn(CC(N)=O)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	59168213	168930	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	5	1	7	2.0	COc1nc(S(C)(=O)=O)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4161922	168930	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	5	1	7	2.0	COc1nc(S(C)(=O)=O)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	145955410	169176	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	381	4	1	5	3.3	CCc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL4165828	169176	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	381	4	1	5	3.3	CCc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	10309892	169245	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1	10.1021/acsmedchemlett.7b00315
	CHEMBL4167021	169245	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1cc(Cl)cc(Cl)c1	10.1021/acsmedchemlett.7b00315
	156018931	184648	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	540	6	0	6	6.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4644412	184648	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	540	6	0	6	6.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44581043	194613	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496152	194613	0	None	1	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	1	8	5.1	COc1cc2nc(N3CCC(N4CCCC(OC)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44561363	196463	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	466	6	1	6	6.3	COc1cc2nc(C3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL515355	196463	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	466	6	1	6	6.3	COc1cc2nc(C3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44581044	200227	0	None	3	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	CHEMBL526474	200227	0	None	3	2	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	11496063	83894	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	CHEMBL207642	83894	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	155540774	179293	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	CHEMBL4483537	179293	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	155543069	179967	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	459	5	2	5	4.7	C[C@@H](Nc1cncc(C2=CCN(C(=O)[C@H]3CCCCN3)CC2)n1)c1ccc(Cl)cc1Cl	10.1021/acs.jmedchem.9b00506
	CHEMBL4522437	179967	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	459	5	2	5	4.7	C[C@@H](Nc1cncc(C2=CCN(C(=O)[C@H]3CCCCN3)CC2)n1)c1ccc(Cl)cc1Cl	10.1021/acs.jmedchem.9b00506
	59456003	80639	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018952	80639	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	44562235	193239	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	495	6	1	7	5.9	COc1cc2nc(N3CCCN(C4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487665	193239	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	495	6	1	7	5.9	COc1cc2nc(N3CCCN(C4CCCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44561332	183001	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL459463	183001	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCN(C4CCCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	58835024	99418	0	None	-398	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	570	8	1	6	5.5	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1	10.1021/jm401101p
	CHEMBL2435852	99418	0	None	-398	2	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysisAntagonist activity at CCR4 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of TARC-induced calcium flux preincubated for 15 mins by spectrophotometric analysis	ChEMBL	570	8	1	6	5.5	Cc1nc(Oc2ccc(C(=O)O)cc2)ccc1CN1CCC(N2C(=O)N(C3CCOCC3)C[C@H]2c2ccccc2)CC1	10.1021/jm401101p
	134324891	181346	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4556507	181346	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	25212379	194641	1	None	-2	2	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496356	194641	1	None	-2	2	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	511	7	2	8	4.7	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	134210775	184555	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	7	0	8	4.8	CCOC(=O)CN1CCCC(C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4643066	184555	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	7	0	8	4.8	CCOC(=O)CN1CCCC(C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	134211057	184404	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641127	184404	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	59455976	93930	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	CHEMBL2326611	93930	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	59456050	93945	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	CHEMBL2326625	93945	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	118706816	119747	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2014.05.021
	CHEMBL3310825	119747	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2014.05.021
	118706816	119747	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2017.07.052
	CHEMBL3310825	119747	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1cccc2c1c(NS(=O)(=O)c1cccc(Cl)c1Cl)nn2C	10.1016/j.bmc.2017.07.052
	44562192	192556	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486656	192556	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	499	10	2	8	4.7	COc1cc2nc(N3CCC(N(C)CCCCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44581103	194552	0	None	6	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495737	194552	0	None	6	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	539	9	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581068	194703	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496787	194703	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	513	7	2	9	3.7	COc1cc2nc(N3CCC(N4CCOC(CO)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	137636569	162653	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	4	1	7	2.5	COc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4060413	162653	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	4	1	7	2.5	COc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	10215932	79902	1	None	-22	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	CHEMBL2011441	79902	1	None	-22	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	383	4	1	6	2.8	COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1	10.1021/acsmedchemlett.7b00315
	145958908	168869	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	401	4	1	5	3.6	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(C(F)(F)F)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4160965	168869	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	401	4	1	5	3.6	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(C(F)(F)F)c1Cl	10.1021/acsmedchemlett.7b00315
	145951136	169531	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	358	4	1	6	2.5	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C#N	10.1021/acsmedchemlett.7b00315
	CHEMBL4171579	169531	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	358	4	1	6	2.5	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1C#N	10.1021/acsmedchemlett.7b00315
	137632086	163216	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	401	4	1	7	2.8	COc1nn(C)c2nc(C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4066934	163216	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	401	4	1	7	2.8	COc1nn(C)c2nc(C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137654717	165511	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	5	1	8	2.5	COc1nn(C)c2nc(N(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4093509	165511	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	430	5	1	8	2.5	COc1nn(C)c2nc(N(C)C)nc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137652889	165684	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	1.7	CNC(=O)Cn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	CHEMBL4095437	165684	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	444	6	2	8	1.7	CNC(=O)Cn1nc(OC)c2c(NS(=O)(=O)c3cccc(Cl)c3Cl)ncnc21	10.1016/j.bmc.2017.07.052
	145951247	169707	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1c(Cl)cccc1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4174254	169707	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	411	4	1	5	3.4	COc1nc(Br)cnc1NS(=O)(=O)c1c(Cl)cccc1Cl	10.1021/acsmedchemlett.7b00315
	10193603	169722	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1cccs1	10.1021/acsmedchemlett.7b00315
	CHEMBL4174488	169722	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	349	4	1	6	2.1	COc1nc(Br)cnc1NS(=O)(=O)c1cccs1	10.1021/acsmedchemlett.7b00315
	44581044	200227	0	None	3	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	CHEMBL526474	200227	0	None	3	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	525	8	1	8	5.4	COCC1CCCN(C2CCN(c3nc(Nc4ccc(Cl)cc4)c4cc(OC)c(OC)cc4n3)CC2)C1	10.1016/j.bmc.2008.11.020
	692856	148141	19	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL383736	148141	19	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of TARC-mediated CEM cell migrationInhibition of TARC-mediated CEM cell migration	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	134325269	177470	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	516	5	1	7	4.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(=O)O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4451802	177470	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	516	5	1	7	4.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C(=O)O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134210768	184233	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4638846	184233	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	134325215	181757	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4566304	181757	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	472	4	0	6	5.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44562155	193410	0	None	19	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488018	193410	0	None	19	2	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at human CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	44430312	94035	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL233046	94035	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	11525206	142006	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL372399	142006	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	127047356	146412	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	146412	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	127045756	146647	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799266	146647	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127046614	146704	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799578	146704	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assayAntagonist activity at human CCR4 expressed in CHO cells by [35S]GTPgammaS assay	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	10287052	169157	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1ncc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4165356	169157	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	367	4	1	5	3.2	COc1ncc(Cl)nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	11234202	169682	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	373	4	1	6	3.3	COc1nc(Cl)cnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4173861	169682	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	373	4	1	6	3.3	COc1nc(Cl)cnc1NS(=O)(=O)c1scc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	44562189	193354	0	None	-7	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487835	193354	0	None	-7	2	Mouse	6.2	pIC50	=	6.2	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	451	6	1	7	4.6	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	156010600	183917	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633920	183917	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	118706830	119761	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310840	119761	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assayAntagonist activity at human CCR4 expressed in CHO cell membranes by [35S]-GTPgammaS radioligand competition assay	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054532	80650	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018962	80650	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	58054387	93927	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326609	93927	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	59456098	93954	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1ccc(F)c2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326634	93954	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	522	8	2	7	4.4	COc1ccc(F)c2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	137639968	163456	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	416	5	2	8	2.5	CNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4069639	163456	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	416	5	2	8	2.5	CNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	137639432	163609	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	4	1	8	1.9	COc1nn(C)c2ncnc(NS(=O)(=O)c3ccc(Cl)s3)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4071299	163609	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	359	4	1	8	1.9	COc1nn(C)c2ncnc(NS(=O)(=O)c3ccc(Cl)s3)c12	10.1016/j.bmc.2017.07.052
	10308962	169822	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1F	10.1021/acsmedchemlett.7b00315
	CHEMBL4176082	169822	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	351	4	1	5	2.7	COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1F	10.1021/acsmedchemlett.7b00315
	137634526	162708	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	417	5	1	8	2.5	COc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4060967	162708	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	417	5	1	8	2.5	COc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	137632304	163256	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1nn(C)c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4067451	163256	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	385	4	1	5	3.7	COc1nn(C)c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137647898	164520	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.5	COCCOc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4082318	164520	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	431	7	1	8	2.5	COCCOc1nn(C)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	137644970	165274	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	5	2	6	2.9	CCOc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	CHEMBL4091069	165274	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	387	5	2	6	2.9	CCOc1n[nH]c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12	10.1016/j.bmc.2017.07.052
	59168178	169763	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	343	4	1	5	2.0	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1	10.1021/acsmedchemlett.7b00315
	CHEMBL4175259	169763	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	343	4	1	5	2.0	COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1	10.1021/acsmedchemlett.7b00315
	137637450	162598	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	460	8	2	9	2.5	COCCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	CHEMBL4059913	162598	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assayAntagonist activity at human recombinant CCR4 receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay	ChEMBL	460	8	2	9	2.5	COCCNc1nc(NS(=O)(=O)c2cccc(Cl)c2Cl)c2c(OC)nn(C)c2n1	10.1016/j.bmc.2017.07.052
	145955548	169391	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	423	5	1	5	4.7	CC(C)(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169258	169391	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assayAntagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT based fluorescence assay	ChEMBL	423	5	1	5	4.7	CC(C)(C)COc1nc(Cl)cnc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1021/acsmedchemlett.7b00315
	134225259	184523	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4642563	184523	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44430315	18638	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL1182360	18638	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233047	18638	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilizationAntagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	155548141	180566	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@@H](N4CCCCC4)[C@@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4537681	180566	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@@H](N4CCCCC4)[C@@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	44562155	193410	0	None	-19	2	Mouse	6.1	pIC50	=	6.1	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488018	193410	0	None	-19	2	Mouse	6.1	pIC50	=	6.1	Functional	Antagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assayAntagonist activity at mouse CCR4 receptor assessed as inhibition of CCL22-induced chemotaxis by bioluminescent assay	ChEMBL	469	6	1	7	4.7	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(F)c(F)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	134324996	178522	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	540	4	0	6	6.5	CC1CN(c2cnc3c(C(F)(F)F)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	CHEMBL4467274	178522	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay	ChEMBL	540	4	0	6	6.5	CC1CN(c2cnc3c(C(F)(F)F)nn(C(C)c4ccc(Cl)cc4Cl)c3n2)CCC1N1CCCCC1	10.1021/acs.jmedchem.9b00506
	134210954	184589	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643609	184589	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44581042	194612	0	None	6	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL496151	194612	0	None	6	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxisAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis	ChEMBL	497	6	2	8	4.5	COc1cc2nc(N3CCC(N4CCCC(O)C4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	44581102	194551	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	CHEMBL495736	194551	0	None	-1	2	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS bindingAntagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced [35S]GTPgammaS binding	ChEMBL	525	8	2	8	4.6	COc1cc2nc(N3CCC(N4CCCC(CO)C4)CC3)nc(NCc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.11.020
	156012782	184143	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637695	184143	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	134210898	184562	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643158	184562	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assayAntagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by calcium 6 dye-based FLIPR assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	59455974	80649	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018961	80649	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation countingAntagonist activity at human CCR4 expressed in CHO membranes assessed as inhibition of [35S]-GTPgammaS binding by scintillation counting	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	44562236	193506	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	512	10	1	8	4.9	CCN(CC)CCN1CCCN(c2nc(Nc3ccc(Cl)cc3)c3cc(OC)c(OC)cc3n2)CC1	10.1016/j.bmc.2008.07.062
	CHEMBL488690	193506	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	512	10	1	8	4.9	CCN(CC)CCN1CCCN(c2nc(Nc3ccc(Cl)cc3)c3cc(OC)c(OC)cc3n2)CC1	10.1016/j.bmc.2008.07.062
	44562190	193355	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	471	8	2	8	3.9	COc1cc2nc(N3CCC(N(C)CCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487836	193355	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assayAntagonist activity at human CCR4 receptor by [35S]GTPgammaS binding assay	ChEMBL	471	8	2	8	3.9	COc1cc2nc(N3CCC(N(C)CCO)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	59455974	80649	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018961	80649	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	59456102	80652	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018964	80652	0	None	-	1	Human	6.0	pKd	=	6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	59456003	80639	0	None	-	1	Human	5.8	pKd	=	5.8	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018952	80639	0	None	-	1	Human	5.8	pKd	=	5.8	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	59456051	80655	0	None	-	1	Human	5.7	pKd	=	5.7	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018967	80655	0	None	-	1	Human	5.7	pKd	=	5.7	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	9959269	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	CHEMBL2018954	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	58054516	80646	0	None	-	1	Human	5.6	pKd	=	5.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	CHEMBL2018959	80646	0	None	-	1	Human	5.6	pKd	=	5.6	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	9827294	80640	3	None	-	1	Human	7.3	pKd	=	7.3	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018953	80640	3	None	-	1	Human	7.3	pKd	=	7.3	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	10416	8660	30	None	309	2	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	46861584	8660	30	None	309	2	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	CHEMBL2018969	8660	30	None	309	2	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	59456067	80656	0	None	-	1	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018968	80656	0	None	-	1	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	70685473	80638	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018951	80638	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	70689680	80642	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018955	80642	0	None	-	1	Human	5.2	pKd	=	5.2	Functional	Antagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin contentAntagonist activity at human CCR4 in human whole blood assessed as inhibition of TARC-induced CD4+ CCR4+lymphocyte chemotaxis measuring F-actin content	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	49798461	17465	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	443	5	1	5	5.3	Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1170725	17465	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	443	5	1	5	5.3	Cc1ncccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	49798437	17331	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	515	8	3	6	4.4	O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1169660	17331	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	515	8	3	6	4.4	O=C(NCCO)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	49798349	17563	0	None	-	1	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	471	6	2	4	5.9	O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1171786	17563	0	None	-	1	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	471	6	2	4	5.9	O=C(O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	16124598	17501	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	472	6	2	5	5.3	O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	CHEMBL1171008	17501	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at CCR4Antagonist activity at CCR4	ChEMBL	472	6	2	5	5.3	O=C(O)c1ccccc1Oc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2010.04.142
	12893	10912	0	None	-	1	Human	7.0	pIC50	<	7	Functional	Binned value from patentBinned value from patent	Guide to Pharmacology	565	7	2	6	6.3	CC1=C(C(=NC(=N1)N2CC(C2)[C@H]3CCCN(C3)C4CC(C4)(C)C(=O)O)N[C@H](C)C5=C(C=C(C=C5)Cl)Cl)Cl	None
	139344142	10912	0	None	-	1	Human	7.0	pIC50	<	7	Functional	Binned value from patentBinned value from patent	Guide to Pharmacology	565	7	2	6	6.3	CC1=C(C(=NC(=N1)N2CC(C2)[C@H]3CCCN(C3)C4CC(C4)(C)C(=O)O)N[C@H](C)C5=C(C=C(C=C5)Cl)Cl)Cl	None
	CHEMBL5314496	10912	0	None	-	1	Human	7.0	pIC50	<	7	Functional	Binned value from patentBinned value from patent	Guide to Pharmacology	565	7	2	6	6.3	CC1=C(C(=NC(=N1)N2CC(C2)[C@H]3CCCN(C3)C4CC(C4)(C)C(=O)O)N[C@H](C)C5=C(C=C(C=C5)Cl)Cl)Cl	None
	nan	10912	0	None	-	1	Human	7.0	pIC50	<	7	Functional	Binned value from patentBinned value from patent	Guide to Pharmacology	565	7	2	6	6.3	CC1=C(C(=NC(=N1)N2CC(C2)[C@H]3CCCN(C3)C4CC(C4)(C)C(=O)O)N[C@H](C)C5=C(C=C(C=C5)Cl)Cl)Cl	None
	5280343	195054	124	None	-16	12	Human	8.3	pIC50	=	8.3	Functional	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	Drug Central	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL1520590	195054	124	None	-16	12	Human	8.3	pIC50	=	8.3	Functional	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	Drug Central	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	CHEMBL50	195054	124	None	-16	12	Human	8.3	pIC50	=	8.3	Functional	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	Drug Central	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
	2812	11551	101	None	3	44	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	CHEMBL104	11551	101	None	3	44	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	4410	9911	106	None	-18	6	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	65015	9911	106	None	-18	6	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	844	9911	106	None	-18	6	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	CHEMBL18442	9911	106	None	-18	6	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	DB06809	9911	106	None	-18	6	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	502	4	6	8	0.4	C1CNCCN(CCCNCCNC1)Cc1ccc(cc1)CN1CCNCCCNCCNCCC1	None
	3793	209988	77	None	-1	4	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	None
	45039617	209988	77	None	-1	4	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	None
	CHEMBL64391	209988	77	None	-1	4	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	Drug Central	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	None
	12153	8446	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patentAntagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patent	Guide to Pharmacology	542	6	1	7	4.9	C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO	None
	134210715	8446	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patentAntagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patent	Guide to Pharmacology	542	6	1	7	4.9	C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO	None
	CHEMBL5314490	8446	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patentAntagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patent	Guide to Pharmacology	542	6	1	7	4.9	C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO	None
	DB15570	8446	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patentAntagonism of CCL22-induce calcium mobilisation in Chem5-hCCR4 cells- <i>N.B.</i> binned value from patent	Guide to Pharmacology	542	6	1	7	4.9	C[C@H](c1c(cc(cc1)Cl)Cl)n1c2nc(cnc2c(n1)C(F)(F)F)N1CC(C1)[C@H]1CCCN(C1)CCO	None
	10417	7855	9	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.	Guide to Pharmacology	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	31259550
	134324842	7855	9	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.	Guide to Pharmacology	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	31259550
	CHEMBL4459231	7855	9	None	3	2	Human	7.4	pIC50	=	7.4	Functional	Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.Antagonism of CCL22-induced calcium flux in Chem-5 hCCR4 cells using a high-throughput FLIPR assay.	Guide to Pharmacology	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	31259550
	10308720	7333	42	None	-2	3	Dog	7.6	pIC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9678	7333	42	None	-2	3	Dog	7.6	pIC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4169247	7333	42	None	-2	3	Dog	7.6	pIC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	25141190	7929	28	None	-1	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	19081254
	9478	7929	28	None	-1	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	19081254
	CHEMBL508207	7929	28	None	-1	2	Human	7.7	pIC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	19081254
	10308720	7333	42	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9678	7333	42	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4169247	7333	42	None	-4	3	Human	7.8	pIC50	=	7.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	10308720	7333	42	None	2	3	Mouse	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9678	7333	42	None	2	3	Mouse	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4169247	7333	42	None	2	3	Mouse	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	23585443	7330	12	None	-3	3	Dog	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9679	7330	12	None	-3	3	Dog	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4172635	7330	12	None	-3	3	Dog	8.5	pIC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	23585443	7330	12	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9679	7330	12	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4172635	7330	12	None	-16	3	Human	8.6	pIC50	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	797	7619	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9430724
	23585443	7330	12	None	3	3	Mouse	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	9679	7330	12	None	3	3	Mouse	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	CHEMBL4172635	7330	12	None	3	3	Mouse	9.0	pIC50	=	9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	28947948
	798	7634	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9430724

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44410965	83834	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	5	2	4	4.1	CCNCc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207290	83834	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	5	2	4	4.1	CCNCc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44406335	80709	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL202085	80709	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44288732	107946	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(F)cc2F)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL295560	107946	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(F)cc2F)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288854	171840	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42266	171840	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	44288730	172751	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(F)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42523	172751	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(F)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289282	176555	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	617	11	3	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc2[nH]ccc2c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44390	176555	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	617	11	3	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc2[nH]ccc2c1	10.1016/j.bmcl.2004.01.072
	5481702	212602	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptor	ChEMBL	556	8	0	4	5.3	CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00639-9
	CHEMBL83338	212602	1	None	-	0	Human	5.0	pIC50	=	5	Binding	Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR4 receptor	ChEMBL	556	8	0	4	5.3	CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1	10.1016/s0960-894x(00)00639-9
	5280343	195054	124	None	-	31	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL1520590	195054	124	None	-	31	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL50	195054	124	None	-	31	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	71720517	93782	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	93782	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	44288960	170575	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42060	170575	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1Cl	10.1016/j.bmcl.2004.01.072
	44400830	78010	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	10	1	4	5.1	CCN(CC)CCCC(C)Nc1nc(Cc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195665	78010	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	10	1	4	5.1	CCN(CC)CCCC(C)Nc1nc(Cc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	5280343	195054	124	None	-	31	Human	4.0	pIC50	=	4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL1520590	195054	124	None	-	31	Human	4.0	pIC50	=	4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL50	195054	124	None	-	31	Human	4.0	pIC50	=	4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	44288899	108042	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	13	2	6	3.6	O=C(C[C@H]1S[C@H](CCc2ccccc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL296245	108042	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	13	2	6	3.6	O=C(C[C@H]1S[C@H](CCc2ccccc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288863	168850	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	6	3.5	O=C(C[C@H]1S[C@H](C2CCCCC2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL416069	168850	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	6	3.5	O=C(C[C@H]1S[C@H](C2CCCCC2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289207	174970	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	633	9	1	5	6.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(Cc2cccc(CN3CCOCC3)c2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43330	174970	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	633	9	1	5	6.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(Cc2cccc(CN3CCOCC3)c2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288557	177063	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccoc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44463	177063	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccoc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	5280343	195054	124	None	-	31	Human	5.0	pIC50	=	5.0	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL1520590	195054	124	None	-	31	Human	5.0	pIC50	=	5.0	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	CHEMBL50	195054	124	None	-	31	Human	5.0	pIC50	=	5.0	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1021/jm301749y
	134211221	184467	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4641873	184467	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	502	7	1	7	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	45104526	207488	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	479	3	3	7	3.8	Cc1c(N2CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL599995	207488	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	479	3	3	7	3.8	Cc1c(N2CCN(C(=O)Nc3ccc(OC(F)(F)F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	44288959	172086	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42334	172086	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	640	11	2	5	6.3	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44430304	158901	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2c(ncn2CC)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL396786	158901	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2c(ncn2CC)n1	10.1016/j.bmcl.2006.10.091
	11285792	7666	34	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	68533031	7666	34	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	801	7666	34	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	CHEMBL2110727	7666	34	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	DB11758	7666	34	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]TARC from CCR4 expressed in CHO cellsDisplacement of [125I]TARC from CCR4 expressed in CHO cells	ChEMBL	696	17	1	7	8.7	CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC	10.1021/jm0509703
	44288962	107250	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	10	2	5	4.5	CN(C)CC(=O)NCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL290845	107250	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	10	2	5	4.5	CN(C)CC(=O)NCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44288985	162321	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	668	14	2	9	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1OC	10.1016/j.bmcl.2004.01.072
	CHEMBL40427	162321	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	668	14	2	9	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1OC	10.1016/j.bmcl.2004.01.072
	44288961	162410	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1ccccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL40468	162410	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1ccccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44289214	164082	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40771	164082	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288776	173098	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	10	2	8	3.3	O=C(CN1C(=O)[C@@H](CC(=O)Nc2nccs2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL42722	173098	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	10	2	8	3.3	O=C(CN1C(=O)[C@@H](CC(=O)Nc2nccs2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44288731	177118	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	11	2	6	3.9	Cc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(C)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44472	177118	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	588	11	2	6	3.9	Cc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(C)c1	10.1016/j.bmcl.2004.01.072
	44288963	177759	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	11	2	7	3.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccs1	10.1016/j.bmcl.2004.01.072
	CHEMBL44561	177759	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	11	2	7	3.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccs1	10.1016/j.bmcl.2004.01.072
	45104751	207697	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	1	1	5	1.9	Cc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL601651	207697	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	1	1	5	1.9	Cc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	3793	209988	77	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	209988	77	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	209988	77	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	134210626	184084	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4636749	184084	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	593	9	1	8	4.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(=O)(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	155557193	181304	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	CHEMBL4555534	181304	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	538	5	1	7	6.0	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(C)(C)O	10.1021/acs.jmedchem.9b00506
	44561588	201332	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL529664	201332	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44406247	147975	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	463	5	0	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(OCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL382826	147975	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	463	5	0	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(OCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	71454500	85767	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113068	85767	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2005.02.084
	44289275	108290	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL298035	108290	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	44289277	170282	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)ccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42021	170282	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)ccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289072	176119	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.3	O=C(C[C@H]1S[C@H](c2cccc(C(F)(F)F)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44187	176119	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.3	O=C(C[C@H]1S[C@H](c2cccc(C(F)(F)F)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44411038	83575	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	471	8	1	4	7.6	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)no2)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL206921	83575	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	471	8	1	4	7.6	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)no2)c1C	10.1016/j.bmcl.2006.01.126
	3793	209988	77	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	209988	77	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	209988	77	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44289062	170438	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42044	170438	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.072
	44289064	177710	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	660	12	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCCc1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44553	177710	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	660	12	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCCc1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2004.01.072
	45104634	207515	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	2	6	1.7	CCN1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	CHEMBL600196	207515	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	2	6	1.7	CCN1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	45104523	208490	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	437	3	3	6	4.0	Cc1c(N2CCN(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL606421	208490	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	437	3	3	6	4.0	Cc1c(N2CCN(C(=O)Nc3ccc(C(C)C)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	134225247	184442	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641595	184442	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	4.6	COC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	134210845	184828	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647188	184828	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	565	8	1	8	3.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	155540774	179293	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	CHEMBL4483537	179293	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	523	5	1	7	4.7	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C(N)=O	10.1021/acs.jmedchem.9b00506
	44411321	145203	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	509	8	1	4	8.6	FC(F)(F)c1ccccc1CN(Cc1csc(Nc2cccc3ccccc23)n1)CC1CCCCC1	10.1016/j.bmcl.2006.01.126
	CHEMBL377421	145203	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	509	8	1	4	8.6	FC(F)(F)c1ccccc1CN(Cc1csc(Nc2cccc3ccccc23)n1)CC1CCCCC1	10.1016/j.bmcl.2006.01.126
	44430311	159159	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	460	11	2	6	5.9	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2cccnc2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL397028	159159	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	460	11	2	6	5.9	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2cccnc2n1	10.1016/j.bmcl.2006.10.091
	44288958	175506	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL43698	175506	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	624	11	2	5	5.6	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44288981	172336	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	7	2	5	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42419	172336	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	7	2	5	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	25141301	192667	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL486840	192667	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	467	6	1	7	5.1	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3ccc(Cl)cc3)c2cc1OC	10.1016/j.bmc.2008.07.062
	156015374	184394	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4640909	184394	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	6	0	7	5.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(F)(F)F)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44411492	145674	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3cnccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL378272	145674	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3cnccc23)n1	10.1016/j.bmcl.2006.01.126
	44288943	171408	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42162	171408	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)cc(Cl)c1	10.1016/j.bmcl.2004.01.072
	44288913	176069	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(F)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL44143	176069	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	596	11	2	6	3.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(F)c1	10.1016/j.bmcl.2004.01.072
	44401027	77327	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL194775	77327	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	134325041	181811	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4567398	181811	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	502	5	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	45104946	207499	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	371	5	0	6	2.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCC3)ccc12	10.1021/jm901652p
	CHEMBL600018	207499	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	371	5	0	6	2.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCC3)ccc12	10.1021/jm901652p
	45104635	207516	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	420	2	2	6	3.9	Cc1c(N2CCN(c3cccc(C(F)(F)F)c3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL600197	207516	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	420	2	2	6	3.9	Cc1c(N2CCN(c3cccc(C(F)(F)F)c3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	45104422	208011	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	406	3	2	6	2.9	Cc1c(N2CCN(C(=O)/C=C/c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL603701	208011	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	406	3	2	6	2.9	Cc1c(N2CCN(C(=O)/C=C/c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	45104527	207489	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	409	3	3	6	2.5	Cc1c(N2CCN(C(=O)NCc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL599996	207489	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	409	3	3	6	2.5	Cc1c(N2CCN(C(=O)NCc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	2812	11551	101	None	-	34	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1021/jm301749y
	CHEMBL104	11551	101	None	-	34	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1021/jm301749y
	71720517	93782	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	93782	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	45104848	207874	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	3	0	5	2.3	CCOc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL602887	207874	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	3	0	5	2.3	CCOc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	10417	7855	9	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	134324842	7855	9	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	CHEMBL4459231	7855	9	None	-	0	Mouse	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	9814022	83886	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	268	3	1	3	5.2	CC(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207589	83886	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	268	3	1	3	5.2	CC(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	692856	148141	19	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL383736	148141	19	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	71461653	85765	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccccc2Cl)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113066	85765	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccccc2Cl)c1	10.1016/j.bmcl.2005.02.084
	134335393	176891	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4443688	176891	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	499	5	1	6	5.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(C3=CC[C@H](N4CCC[C@H]4CO)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	11496063	83894	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	CHEMBL207642	83894	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	44288978	175515	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	585	10	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43706	175515	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	585	10	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288827	175580	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43758	175580	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	71458049	85774	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	359	11	1	4	4.7	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(F)cc2)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113075	85774	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	359	11	1	4	4.7	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(F)cc2)c1	10.1016/j.bmcl.2005.02.084
	44561561	185780	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL470962	185780	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	439	6	1	7	4.5	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44288791	106972	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	12	2	6	3.3	CC(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL288256	106972	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	12	2	6	3.3	CC(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44430309	93999	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ccccc12	10.1016/j.bmcl.2006.10.091
	CHEMBL232841	93999	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ccccc12	10.1016/j.bmcl.2006.10.091
	134325106	178030	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4460062	178030	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	500	4	0	6	6.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	45104945	207498	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	385	5	0	6	2.7	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCCC3)ccc12	10.1021/jm901652p
	CHEMBL600017	207498	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	385	5	0	6	2.7	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCCCC3)ccc12	10.1021/jm901652p
	44430312	94035	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL233046	94035	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	499	5	2	7	3.7	O=C([C@@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	44288880	108335	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	5	5.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL298454	108335	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	5	5.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	3793	209988	77	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	209988	77	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	209988	77	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22Inverse agonist activity at CCR4 in human HTLA cells assessed as depression of basal activity incubated for 20 mins by beta arrestin-recruitment mediated luciferase reporter gene assay in absence of CCL22	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44411325	175657	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1	10.1016/j.bmcl.2006.01.126
	CHEMBL438248	175657	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1	10.1016/j.bmcl.2006.01.126
	44288879	176122	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL44188	176122	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44400833	77482	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	392	11	1	5	5.1	CCN(CC)CCCC(C)Nc1nc(COc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195061	77482	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	392	11	1	5	5.1	CCN(CC)CCCC(C)Nc1nc(COc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	44401066	133193	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CN(C)CCCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL365155	133193	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CN(C)CCCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44289208	170625	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	7	1	5	4.6	CN1CCN(C(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	CHEMBL42065	170625	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	7	1	5	4.6	CN1CCN(C(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	71452724	85771	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113072	85771	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	375	11	1	4	5.2	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)cc2)c1	10.1016/j.bmcl.2005.02.084
	45104633	207180	22	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	290	1	2	6	1.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL598070	207180	22	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	290	1	2	6	1.3	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	9943773	84079	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	286	2	1	3	5.1	CC(C)(C)c1csc(Nc2cccc3c2CCCC3)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL208249	84079	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	286	2	1	3	5.1	CC(C)(C)c1csc(Nc2cccc3c2CCCC3)n1	10.1016/j.bmcl.2006.01.126
	44411033	84124	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	299	3	1	4	5.2	CCn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	CHEMBL208458	84124	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	299	3	1	4	5.2	CCn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	44430302	93893	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2nc[nH]c12	10.1016/j.bmcl.2006.10.091
	CHEMBL232639	93893	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2nc[nH]c12	10.1016/j.bmcl.2006.10.091
	44289116	176059	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	11	2	6	3.7	CC(C)(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL44134	176059	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	572	11	2	6	3.7	CC(C)(C)CCNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	176	7186	66	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	7186	66	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	7186	66	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	7186	66	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	7186	66	None	-6	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	134324891	181346	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4556507	181346	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	458	4	0	6	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	9922232	172538	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	296	3	1	3	5.6	CC(C)(C)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL424689	172538	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	296	3	1	3	5.6	CC(C)(C)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44289186	171861	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42270	171861	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	3.8	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1	10.1016/j.bmcl.2004.01.072
	44289105	105208	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	656	13	2	6	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL275593	105208	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	656	13	2	6	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288818	162191	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40366	162191	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44400899	77358	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	390	11	1	4	5.3	CCN(CC)CCCC(C)Nc1nc(CCc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL194930	77358	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	390	11	1	4	5.3	CCN(CC)CCCC(C)Nc1nc(CCc2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	44288912	172864	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	678	13	2	7	4.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCNS(=O)(=O)CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42586	172864	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	678	13	2	7	4.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCNS(=O)(=O)CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134211126	184348	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4640439	184348	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	515	7	1	7	4.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(N)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	10308720	7333	42	None	-	0	Dog	7.6	pIC50	=	7.6	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9678	7333	42	None	-	0	Dog	7.6	pIC50	=	7.6	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4169247	7333	42	None	-	0	Dog	7.6	pIC50	=	7.6	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	333	4	1	5	2.6	COc1nccnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	44289241	107190	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL290201	107190	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288996	176139	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL44198	176139	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	44289039	107019	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2004.01.072
	CHEMBL288655	107019	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2004.01.072
	44289340	108024	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	664	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1F	10.1016/j.bmcl.2004.01.072
	CHEMBL296152	108024	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	664	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(C(F)(F)F)c1F	10.1016/j.bmcl.2004.01.072
	44288911	174703	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	595	11	2	7	3.1	Cc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)n1C	10.1016/j.bmcl.2004.01.072
	CHEMBL43143	174703	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	595	11	2	7	3.1	Cc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)n1C	10.1016/j.bmcl.2004.01.072
	44400829	78092	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	412	9	1	4	6.4	CCN(CC)CCCC(C)Nc1nc(-c2ccc3ccccc3c2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195751	78092	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	412	9	1	4	6.4	CCN(CC)CCCC(C)Nc1nc(-c2ccc3ccccc3c2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	44400922	75425	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	11	1	5	4.6	CCN(CC)CCCC(C)Nc1ccnc(COc2cccc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL191915	75425	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	376	11	1	5	4.6	CCN(CC)CCCC(C)Nc1ccnc(COc2cccc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	44400881	78180	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(COc2cc(Cl)cc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195893	78180	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(COc2cc(Cl)cc(Cl)c2)n1	10.1016/j.bmcl.2005.02.084
	45104427	207628	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	473	4	3	8	2.0	CC(=O)Nc1ccc(S(=O)(=O)N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)cc1	10.1021/jm901652p
	CHEMBL601217	207628	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	473	4	3	8	2.0	CC(=O)Nc1ccc(S(=O)(=O)N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)cc1	10.1021/jm901652p
	134325076	178964	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4473604	178964	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	579	7	1	8	4.4	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCS(N)(=O)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134211098	184823	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4647117	184823	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	564	8	0	8	4.6	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	9856506	83533	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	260	2	1	3	4.8	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL206789	83533	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	260	2	1	3	4.8	Cc1cccc(Nc2nc(C(C)(C)C)cs2)c1C	10.1016/j.bmcl.2006.01.126
	44430305	93896	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ncn(CC)c12	10.1016/j.bmcl.2006.10.091
	CHEMBL232641	93896	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	477	12	2	7	5.7	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)nc2ncn(CC)c12	10.1016/j.bmcl.2006.10.091
	11223594	77859	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195298	77859	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	2	5	5.3	CCN(CC)CCCC(C)Nc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44430315	18638	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL1182360	18638	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233047	18638	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	409	11	2	5	5.3	CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	44430308	158904	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	433	10	1	5	5.7	CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL396787	158904	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	433	10	1	5	5.7	CCN(CC)CCCC(C)Nc1ccc2cnn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	44401007	77615	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195103	77615	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	410	11	1	5	5.3	CCN(CC)CCCC(C)Nc1ccnc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44289401	170224	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	604	10	2	6	4.0	O=C(CN1C(=O)[C@@H](CC(=O)N[C@@H]2CCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL41983	170224	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	604	10	2	6	4.0	O=C(CN1C(=O)[C@@H](CC(=O)N[C@@H]2CCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44289082	173351	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccco2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42799	173351	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	550	11	2	7	2.9	O=C(C[C@H]1S[C@H](c2ccco2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	23585443	7330	12	None	-	0	Dog	8.5	pIC50	=	8.5	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9679	7330	12	None	-	0	Dog	8.5	pIC50	=	8.5	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	CHEMBL4172635	7330	12	None	-	0	Dog	8.5	pIC50	=	8.5	Binding	Antagonist activity at dog CCR4Antagonist activity at dog CCR4	ChEMBL	351	4	1	5	2.7	COc1nc(F)cnc1NS(=O)(=O)c1cccc(c1Cl)Cl	10.1021/acsmedchemlett.7b00315
	9900444	83936	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3ncccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207857	83936	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	283	2	1	4	4.7	CC(C)(C)c1csc(Nc2cccc3ncccc23)n1	10.1016/j.bmcl.2006.01.126
	44406309	140314	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3ccnc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL370861	140314	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3ccnc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	692856	148141	19	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL383736	148141	19	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	240	2	1	3	4.3	Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44288879	176122	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL44188	176122	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44400947	78097	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	396	11	1	5	4.9	CCN(CC)CCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195764	78097	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	396	11	1	5	4.9	CCN(CC)CCCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	11496063	83894	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	CHEMBL207642	83894	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]MDC from CCR4 expressed in human CEM cell lineDisplacement of [125I]MDC from CCR4 expressed in human CEM cell line	ChEMBL	447	8	1	4	8.0	c1ccc2c(Nc3nc(CN(CC4CCCCC4)CC4CCCCC4)cs3)cccc2c1	10.1016/j.bmcl.2006.01.126
	44288903	173160	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	5	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42757	173160	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	5	5.4	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	45104849	209302	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	4	0	5	4.2	CCC1CCC(Oc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)CC1	10.1021/jm901652p
	CHEMBL611508	209302	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	4	0	5	4.2	CCC1CCC(Oc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)CC1	10.1021/jm901652p
	45104748	207816	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	3.5	Cc1cccc(N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)c1C	10.1021/jm901652p
	CHEMBL602474	207816	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	3.5	Cc1cccc(N2CCN(c3c(C)c4c(O)cc(O)cc4oc3=O)CC2)c1C	10.1021/jm901652p
	44289098	108163	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	13	2	8	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL297173	108163	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	13	2	8	3.5	COc1ccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c(OC)c1	10.1016/j.bmcl.2004.01.072
	134335394	179121	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	CHEMBL4475665	179121	0	None	-	0	Mouse	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	134225255	184104	10	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	184104	10	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44289027	108009	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	652	8	1	5	6.3	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL296067	108009	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	652	8	1	5	6.3	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288779	108190	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	9	1	5	5.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL297335	108190	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	571	9	1	5	5.5	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289036	169885	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2cccs2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL417712	169885	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2cccs2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289106	172305	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	620	13	2	8	3.3	COc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(OC)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42411	172305	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	620	13	2	8	3.3	COc1ccc([C@H]2S[C@H](CC(=O)NCc3cccc4ccccc34)C(=O)N2CC(=O)NCCCN2CCOCC2)c(OC)c1	10.1016/j.bmcl.2004.01.072
	21866580	83921	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	481	8	1	3	8.0	Cc1cccc(Nc2cccc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)n2)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL207780	83921	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	481	8	1	3	8.0	Cc1cccc(Nc2cccc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)n2)c1C	10.1016/j.bmcl.2006.01.126
	44289276	174705	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	634	11	2	7	4.7	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1csc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43144	174705	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	634	11	2	7	4.7	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1csc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288726	176218	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	561	11	2	7	2.7	O=C(C[C@H]1S[C@H](c2ccncc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44262	176218	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	561	11	2	7	2.7	O=C(C[C@H]1S[C@H](c2ccncc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	71720517	93782	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	93782	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	44289235	108157	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	8	2	5	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL297145	108157	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	584	8	2	5	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCC(=O)N2CCNCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289204	176628	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	614	10	2	6	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44401	176628	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	614	10	2	6	4.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134325003	182161	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4575089	182161	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	543	7	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC(N)=O)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	134225259	184523	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4642563	184523	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	517	7	2	8	3.0	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44288904	171447	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	586	11	2	5	4.9	CN(C)CCCNC(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42168	171447	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	586	11	2	5	4.9	CN(C)CCCNC(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44289227	176214	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	600	11	1	5	5.2	CN(C)CCCN(C)C(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL44259	176214	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	600	11	1	5	5.2	CN(C)CCCN(C)C(=O)CN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44430317	94117	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	439	12	3	7	4.8	CCN(CC)CCCC(C)Nc1nc(NC)nc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233261	94117	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	439	12	3	7	4.8	CCN(CC)CCCC(C)Nc1nc(NC)nc(NCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	44288898	175467	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	515	8	1	4	5.4	CN(C)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL43661	175467	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	515	8	1	4	5.4	CN(C)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	155531126	178386	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4465359	178386	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCCCC4)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	21866577	82740	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	285	2	1	4	4.7	Cn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	CHEMBL205279	82740	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	285	2	1	4	4.7	Cn1ccc2c(Nc3nc(C(C)(C)C)cs3)cccc21	10.1016/j.bmcl.2006.01.126
	134210898	184562	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643158	184562	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	516	7	1	7	4.7	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44411191	147017	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	484	8	1	4	7.4	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)nn2C)c1C	10.1016/j.bmcl.2006.01.126
	CHEMBL380537	147017	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	484	8	1	4	7.4	Cc1cccc(Nc2cc(CN(Cc3ccccc3C(F)(F)F)CC3CCCCC3)nn2C)c1C	10.1016/j.bmcl.2006.01.126
	156012782	184143	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637695	184143	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	545	7	1	8	3.6	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44289203	177313	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	12	2	6	5.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL44498	177313	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	12	2	6	5.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134324973	177166	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4447900	177166	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	486	4	0	6	5.8	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4C)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	45104844	207699	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	1	6	1.6	COc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL601653	207699	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	304	2	1	6	1.6	COc1cc(O)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	134225255	184104	10	None	-	0	Mouse	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assayAntagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	184104	10	None	-	0	Mouse	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assayAntagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% mouse serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	71720517	93782	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	93782	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	134211057	184404	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	CHEMBL4641127	184404	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	529	7	1	7	4.3	CC(=O)NCCN1CCC[C@H](C2CN(c3cnc4c(C)nn([C@H](C)c5ccc(Cl)cc5Cl)c4n3)C2)C1	10.1021/acs.jmedchem.0c00988
	44289341	170252	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	6	4.4	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	CHEMBL42001	170252	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	626	11	2	6	4.4	Cc1c(Cl)cccc1CNC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O	10.1016/j.bmcl.2004.01.072
	44288923	170447	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)ccc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42046	170447	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cc(Cl)ccc1Cl	10.1016/j.bmcl.2004.01.072
	44288683	175849	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	578	11	2	6	3.5	O=C(C[C@H]1S[C@H](c2ccc(F)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43969	175849	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	578	11	2	6	3.5	O=C(C[C@H]1S[C@H](c2ccc(F)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	71449124	85768	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)c(Cl)c2)c1	10.1016/j.bmcl.2005.02.084
	CHEMBL2113069	85768	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	409	11	1	4	5.9	CCN(CC)CCCC(C)Nc1ccnc(COc2ccc(Cl)c(Cl)c2)c1	10.1016/j.bmcl.2005.02.084
	134336138	184274	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639418	184274	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	527	7	1	8	4.2	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	45104752	208362	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	1	0	6	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc3c(cc12)OCO3	10.1021/jm901652p
	CHEMBL605581	208362	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	302	1	0	6	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc3c(cc12)OCO3	10.1021/jm901652p
	45104423	207698	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	330	2	2	6	1.3	C=CC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	CHEMBL601652	207698	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	330	2	2	6	1.3	C=CC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	45104321	207500	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	276	1	3	6	0.9	Cc1c(N2CCNCC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL600019	207500	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	276	1	3	6	0.9	Cc1c(N2CCNCC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	45104425	207658	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	2.5	Cc1c(N2CCN(C(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL601424	207658	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	380	2	2	6	2.5	Cc1c(N2CCN(C(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	134335394	179121	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	CHEMBL4475665	179121	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	494	4	0	6	6.3	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1C	10.1021/acs.jmedchem.9b00506
	44411266	83532	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	274	3	1	3	5.3	CC(C)c1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	CHEMBL206788	83532	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	274	3	1	3	5.3	CC(C)c1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	44289342	172891	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	606	11	2	6	4.1	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1C	10.1016/j.bmcl.2004.01.072
	CHEMBL42600	172891	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	606	11	2	6	4.1	Cc1cccc(CNC(=O)C[C@H]2S[C@H](c3ccc(Cl)cc3Cl)N(CC(=O)NCCCN3CCOCC3)C2=O)c1C	10.1016/j.bmcl.2004.01.072
	156010350	183861	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633133	183861	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	531	7	2	8	3.2	CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	10133595	83843	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	367	8	1	4	6.2	CC(C)CN(Cc1csc(Nc2cccc3ccccc23)n1)CC(C)C	10.1016/j.bmcl.2006.01.126
	CHEMBL207320	83843	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	367	8	1	4	6.2	CC(C)CN(Cc1csc(Nc2cccc3ccccc23)n1)CC(C)C	10.1016/j.bmcl.2006.01.126
	9899450	83314	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	232	2	1	3	4.2	CC(C)(C)c1csc(Nc2ccccc2)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL206103	83314	1	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	232	2	1	3	4.2	CC(C)(C)c1csc(Nc2ccccc2)n1	10.1016/j.bmcl.2006.01.126
	45104846	207541	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	301	2	0	5	1.9	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(N(C)C)ccc12	10.1021/jm901652p
	CHEMBL600409	207541	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	301	2	0	5	1.9	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(N(C)C)ccc12	10.1021/jm901652p
	45104845	205953	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	318	3	0	6	1.9	COc1cc(OC)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL589521	205953	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	318	3	0	6	1.9	COc1cc(OC)c2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	21866574	83865	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	271	2	2	3	4.7	CC(C)(C)c1csc(Nc2cccc3[nH]ccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL207479	83865	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	271	2	2	3	4.7	CC(C)(C)c1csc(Nc2cccc3[nH]ccc23)n1	10.1016/j.bmcl.2006.01.126
	44430303	93895	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2[nH]cnc2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL232640	93895	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	449	11	3	6	5.2	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2[nH]cnc2n1	10.1016/j.bmcl.2006.10.091
	134225255	184104	10	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	184104	10	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	11525206	142006	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL372399	142006	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2006.10.091
	11525206	142006	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL372399	142006	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44430310	94034	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2ccccc2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL233045	94034	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	459	11	2	5	6.5	CCN(CC)CCCC(C)Nc1nc(NCc2ccc(Cl)cc2Cl)c2ccccc2n1	10.1016/j.bmcl.2006.10.091
	3793	209988	77	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	209988	77	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	209988	77	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	3793	209988	77	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	209988	77	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	209988	77	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44562156	193508	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL488704	193508	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	511	6	1	7	5.2	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(Nc3cccc(Br)c3)c2cc1OC	10.1016/j.bmc.2008.07.062
	45104847	207215	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	2	0	5	1.9	COc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	CHEMBL598339	207215	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	288	2	0	5	1.9	COc1ccc2c(C)c(N3CCN(C)CC3)c(=O)oc2c1	10.1021/jm901652p
	156010372	183887	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4633494	183887	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	508	6	0	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCC#N)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	45104943	207903	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	5	0	6	3.5	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCc3cccs3)ccc12	10.1021/jm901652p
	CHEMBL603104	207903	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	384	5	0	6	3.5	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCc3cccs3)ccc12	10.1021/jm901652p
	45104524	207587	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	417	7	3	6	3.3	CCCCCCCNC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	CHEMBL600805	207587	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	417	7	3	6	3.3	CCCCCCCNC(=O)N1CCN(c2c(C)c3c(O)cc(O)cc3oc2=O)CC1	10.1021/jm901652p
	4015979	84122	3	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	302	3	1	3	5.7	c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	CHEMBL208452	84122	3	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	302	3	1	3	5.7	c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	134210768	184233	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4638846	184233	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	530	8	1	7	5.1	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCCC(=O)O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44406246	79801	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	479	9	2	6	4.3	CC(C)[C@@H](CNc1nccc(OCc2ccc(Cl)cc2Cl)n1)NC(=O)C1CCCN(C)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL200966	79801	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	479	9	2	6	4.3	CC(C)[C@@H](CNc1nccc(OCc2ccc(Cl)cc2Cl)n1)NC(=O)C1CCCN(C)C1	10.1016/j.bmcl.2005.09.022
	44288897	108263	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	529	9	1	4	5.7	CN(C)CCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL297854	108263	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	529	9	1	4	5.7	CN(C)CCCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44288663	107036	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	641	11	2	6	4.5	CN1CCN(CCCNC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	CHEMBL288800	107036	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	641	11	2	6	4.5	CN1CCN(CCCNC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	156010600	183917	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4633920	183917	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	550	7	0	8	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(C)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	134325016	181432	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	CHEMBL4558456	181432	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	513	5	1	8	4.3	C[C@@H]1CN(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)CC[C@@H]1N1CCC[C@H]1CO	10.1021/acs.jmedchem.9b00506
	45104747	207794	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	370	2	2	6	3.0	Cc1c(N2CCN(c3ccc(F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL602269	207794	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	370	2	2	6	3.0	Cc1c(N2CCN(c3ccc(F)cc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	134211225	184704	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4645325	184704	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	557	8	1	7	5.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCNC(=O)C(C)C)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	44406338	79697	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	434	5	2	6	2.8	O=C([C@H]1CCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL200465	79697	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	434	5	2	6	2.8	O=C([C@H]1CCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44288972	173211	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	8	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42774	173211	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	638	8	1	5	5.9	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)N2CCC(N3CCCC3)CC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	45104525	208121	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	487	4	3	7	4.7	Cc1c(N2CCN(C(=O)Nc3ccccc3Oc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL604330	208121	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	487	4	3	7	4.7	Cc1c(N2CCN(C(=O)Nc3ccccc3Oc3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	44289283	108031	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(CN1C(=O)[C@@H](CC(=O)NC(c2ccccc2)c2ccccc2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL296192	108031	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(CN1C(=O)[C@@H](CC(=O)NC(c2ccccc2)c2ccccc2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44289063	168750	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1-c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL415902	168750	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	654	12	2	6	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccccc1-c1ccccc1	10.1016/j.bmcl.2004.01.072
	44289097	185404	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	680	11	2	6	5.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL46748	185404	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	680	11	2	6	5.2	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccc(Cl)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.072
	45104426	208633	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	416	3	2	7	2.0	Cc1c(N2CCN(S(=O)(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL607137	208633	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	416	3	2	7	2.0	Cc1c(N2CCN(S(=O)(=O)c3ccccc3)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	44401118	77845	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uMInhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uM	ChEMBL	388	10	1	4	5.7	CCN(CC)CCCC(C)Nc1nc(/C=C/c2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	CHEMBL195203	77845	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uMInhibitory concentration against human C-C chemokine receptor type 4; range = 3.6-6.1 uM	ChEMBL	388	10	1	4	5.7	CCN(CC)CCCC(C)Nc1nc(/C=C/c2ccccc2)nc2ccccc12	10.1016/j.bmcl.2005.02.084
	134324770	177722	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	CHEMBL4455432	177722	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	509	5	1	7	5.2	C[C@@H]1CC(c2cnc3c(C#N)nn([C@H](C)c4ccc(Cl)cc4Cl)c3n2)=CC[C@@H]1N1CCC[C@H]1CN	10.1021/acs.jmedchem.9b00506
	134225255	184104	10	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4637143	184104	10	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	499	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CCO)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	44561217	195895	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL510375	195895	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCN(C(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44289057	172121	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2ccsc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42360	172121	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	566	11	2	7	3.4	O=C(C[C@H]1S[C@H](c2ccsc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289281	107880	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	618	10	2	6	4.4	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL295057	107880	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	618	10	2	6	4.4	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCc3ccccc32)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	45104944	207497	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	387	5	0	7	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCOCC3)ccc12	10.1021/jm901652p
	CHEMBL600016	207497	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	387	5	0	7	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(OCCN3CCOCC3)ccc12	10.1021/jm901652p
	44288799	108309	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL298230	108309	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	10417	7855	9	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	134324842	7855	9	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	CHEMBL4459231	7855	9	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	510	5	1	7	5.3	OC[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(n1)n(nc2C#N)[C@@H](c1ccc(cc1Cl)Cl)C	10.1021/acs.jmedchem.9b00506
	16724339	193216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	CHEMBL487635	193216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assayDisplacement of [121I]CCL22 from human CCR4 receptor by scintillation proximity assay	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.07.062
	16724339	193216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL487635	193216	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	453	6	1	7	4.8	COc1cc2nc(N3CCC(N4CCCC4)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	44406282	79479	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	CHEMBL199733	79479	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	462	5	1	6	3.4	CN1CCCC(C(=O)N2CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.bmcl.2005.09.022
	44289055	107136	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	568	11	2	7	3.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccco1	10.1016/j.bmcl.2004.01.072
	CHEMBL289661	107136	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	568	11	2	7	3.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1ccco1	10.1016/j.bmcl.2004.01.072
	44288575	161961	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	10	2	6	3.6	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCCC2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	CHEMBL40238	161961	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	570	10	2	6	3.6	O=C(CN1C(=O)[C@@H](CC(=O)NC2CCCCC2)S[C@@H]1c1ccc(Cl)cc1Cl)NCCCN1CCOCC1	10.1016/j.bmcl.2004.01.072
	44288698	175872	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43988	175872	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2cccc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	134210954	184589	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4643609	184589	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	551	7	1	8	3.5	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCS(N)(=O)=O)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	3793	209988	77	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	209988	77	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	209988	77	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	25141190	7929	28	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	9478	7929	28	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	CHEMBL508207	7929	28	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	467	6	1	7	5.2	COc1cc2c(NC3CCCCCC3)nc(nc2cc1OC)N1CCC(CC1)N1CCCCC1	10.1016/j.bmc.2008.05.036
	44561137	193498	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	CHEMBL488640	193498	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPADisplacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells by SPA	ChEMBL	427	6	1	7	4.3	COc1cc2nc(N3CCC(N(C)C)CC3)nc(NC3CCCCCC3)c2cc1OC	10.1016/j.bmc.2008.05.036
	45104850	207875	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	394	5	0	6	3.4	COc1ccc(COc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)cc1	10.1021/jm901652p
	CHEMBL602888	207875	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	394	5	0	6	3.4	COc1ccc(COc2ccc3c(C)c(N4CCN(C)CC4)c(=O)oc3c2)cc1	10.1021/jm901652p
	134211185	183932	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	CHEMBL4634054	183932	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	488	6	1	7	4.2	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC([C@H]4CCCN(CCO)C4)C3)cnc12	10.1021/acs.jmedchem.0c00988
	156018849	184686	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4645037	184686	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	513	6	1	8	3.8	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(CC(=O)O)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	45104750	207696	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	274	1	1	5	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)ccc12	10.1021/jm901652p
	CHEMBL601650	207696	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	274	1	1	5	1.6	Cc1c(N2CCN(C)CC2)c(=O)oc2cc(O)ccc12	10.1021/jm901652p
	44289343	172640	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42491	172640	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	646	11	2	6	4.8	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1Cl	10.1016/j.bmcl.2004.01.072
	3793	209988	77	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	45039617	209988	77	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	CHEMBL64391	209988	77	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with centrifuged compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	704	11	0	12	5.6	CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	10.1021/jm301749y
	44430313	156580	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	485	5	2	7	3.3	O=C([C@@H]1CCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	CHEMBL394859	156580	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	485	5	2	7	3.3	O=C([C@@H]1CCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2006.10.091
	44411037	83558	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	266	2	1	3	4.9	CC(C)(C)c1coc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL206878	83558	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	266	2	1	3	4.9	CC(C)(C)c1coc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	9814340	146287	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	282	2	1	3	5.3	CC(C)(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL379460	146287	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	282	2	1	3	5.3	CC(C)(C)c1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44410966	175821	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	311	6	1	4	4.9	CCN(CC)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	CHEMBL439518	175821	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	311	6	1	4	4.9	CCN(CC)Cc1csc(Nc2cccc3ccccc23)n1	10.1016/j.bmcl.2006.01.126
	44406355	79539	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.0	O=C(C1CCCNC1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	CHEMBL199913	79539	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cellsDisplacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells	ChEMBL	448	5	2	6	3.0	O=C(C1CCCNC1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.bmcl.2005.09.022
	44288828	107234	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2c(Cl)cccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL290678	107234	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2c(Cl)cccc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289242	162214	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40377	162214	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	642	11	2	6	5.2	C[C@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44289205	169949	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	598	8	2	5	5.0	CN1CCC(NC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	CHEMBL418072	169949	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	598	8	2	5	5.0	CN1CCC(NC(=O)CN2C(=O)[C@@H](CC(=O)NCc3cccc4ccccc34)S[C@@H]2c2ccc(Cl)cc2Cl)CC1	10.1016/j.bmcl.2004.01.072
	44288996	176139	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	CHEMBL44198	176139	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	592	11	2	6	4.0	C[C@@H](NC(=O)C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)c1ccccc1	10.1016/j.bmcl.2004.01.072
	44401087	77901	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CCN(CC)CCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL195484	77901	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	382	10	1	5	4.5	CCN(CC)CCCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44430306	93997	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2ncn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	CHEMBL232839	93997	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2ncn(Cc3ccc(Cl)cc3Cl)c2n1	10.1016/j.bmcl.2006.10.091
	44430307	93998	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2c(ncn2Cc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	CHEMBL232840	93998	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]MDC from human CCR4 expressed in HEK293 cellsDisplacement of [125I]MDC from human CCR4 expressed in HEK293 cells	ChEMBL	434	10	1	6	5.1	CCN(CC)CCCC(C)Nc1ncc2c(ncn2Cc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2006.10.091
	44288818	162191	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL40366	162191	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(CC1SC(c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288682	172863	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL42585	172863	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	594	11	2	6	4.0	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	3117	214620	103	None	-4	16	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	214620	103	None	-4	16	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	45104424	208086	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	352	2	2	6	1.4	Cc1c(N2CCN(C(=O)CCl)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	CHEMBL604130	208086	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cellsDisplacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells	ChEMBL	352	2	2	6	1.4	Cc1c(N2CCN(C(=O)CCl)CC2)c(=O)oc2cc(O)cc(O)c12	10.1021/jm901652p
	155541406	179774	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	CHEMBL4518040	179774	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay	ChEMBL	525	6	0	7	6.0	Cc1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(N3CC[C@H](N4CCC[C@H]4CCC#N)[C@H](C)C3)cnc12	10.1021/acs.jmedchem.9b00506
	5071677	82775	19	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	358	3	1	3	7.0	CC(C)(C)c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	CHEMBL205490	82775	19	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	358	3	1	3	7.0	CC(C)(C)c1ccc(-c2csc(Nc3cccc4ccccc34)n2)cc1	10.1016/j.bmcl.2006.01.126
	44411322	147693	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	CHEMBL382244	147693	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]TARC from CCR4 expressed in human CEM cell lineDisplacement of [125I]TARC from CCR4 expressed in human CEM cell line	ChEMBL	246	2	1	3	4.5	Cc1ccccc1Nc1nc(C(C)(C)C)cs1	10.1016/j.bmcl.2006.01.126
	44288481	107928	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	557	8	1	5	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL295405	107928	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	557	8	1	5	5.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44288998	173279	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	10	3	5	4.3	NCCNC(=O)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	CHEMBL42786	173279	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	558	10	3	5	4.3	NCCNC(=O)CCN1C(=O)[C@@H](CC(=O)NCc2cccc3ccccc23)S[C@@H]1c1ccc(Cl)cc1Cl	10.1016/j.bmcl.2004.01.072
	44289278	174629	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)cc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	CHEMBL43092	174629	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	628	11	2	6	4.6	O=C(C[C@H]1S[C@H](c2cc(Cl)cc(Cl)c2)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc2ccccc12	10.1016/j.bmcl.2004.01.072
	44401153	142060	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	368	9	1	5	4.1	CCN(CC)CCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	CHEMBL372670	142060	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibitory concentration against human C-C chemokine receptor type 4Inhibitory concentration against human C-C chemokine receptor type 4	ChEMBL	368	9	1	5	4.1	CCN(CC)CCNc1nccc(OCc2ccc(Cl)cc2Cl)n1	10.1016/j.bmcl.2005.02.084
	44288964	171683	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1	10.1016/j.bmcl.2004.01.072
	CHEMBL42226	171683	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cellsInhibition of [125I]MDC binding to recombinant human C-C chemokine receptor type 4 (CCR4) expressed in murine pre-B cells	ChEMBL	612	11	2	6	4.1	O=C(C[C@H]1S[C@H](c2ccc(Cl)cc2Cl)N(CC(=O)NCCCN2CCOCC2)C1=O)NCc1cccc(Cl)c1	10.1016/j.bmcl.2004.01.072
	134210933	184285	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	CHEMBL4639600	184285	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assayAntagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 addition and measured after 60 mins in presence of 100% human serum by CellTiter-Glo assay	ChEMBL	535	6	1	8	4.7	C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(N3CC([C@H]4CCCN(Cc5cnc[nH]5)C4)C3)nc21	10.1021/acs.jmedchem.0c00988
	71720517	93782	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	CHEMBL2324200	93782	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Inhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assayInhibition of CCL22-stimulated CCR4 in human HTLA cells pre-incubated for 20 mins with Tween-80-treated compound solution measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay	ChEMBL	822	2	2	4	6.0	O=C1OC(c2cc(I)c(O)c(I)c2)(c2c(I)cc(O)cc2I)c2ccccc21	10.1021/jm301749y
	127047356	146412	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	146412	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	59456102	80652	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2018964	80652	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	59455976	93930	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	CHEMBL2326611	93930	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	504	8	3	7	3.7	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(CO)cccc32)c1	10.1021/jm301572h
	71583488	93935	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	CHEMBL2326616	93935	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	546	9	2	8	3.9	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COC2)c1	10.1021/jm301572h
	59455990	93952	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326632	93952	0	None	-	1	Human	6.0	pKd	=	6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	59456103	93942	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	CHEMBL2326622	93942	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	573	9	3	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2CCCCN2)c1	10.1021/jm301572h
	56849395	93965	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326926	93965	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	540	9	3	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(C)c(F)c1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59456014	93941	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	CHEMBL2326621	93941	0	None	-	1	Human	6.9	pKd	=	6.9	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	9	3	8	4.0	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)N)c1	10.1021/jm301572h
	11525206	142006	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL372399	142006	0	None	-	1	Human	6.8	pKd	=	6.8	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	127045756	146647	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799266	146647	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	59455988	93940	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	CHEMBL2326620	93940	0	None	-	1	Human	6.7	pKd	=	6.7	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	547	10	3	8	3.8	CN[C@H](C)C(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1021/jm301572h
	9959269	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	CHEMBL2018954	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	9959269	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	CHEMBL2018954	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmc.2014.05.021
	9959269	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	CHEMBL2018954	80641	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1021/jm301572h
	59456050	93945	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	CHEMBL2326625	93945	0	None	-	1	Human	6.6	pKd	=	6.6	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	589	9	2	9	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2COCCN2C)c1	10.1021/jm301572h
	118706830	119761	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310840	119761	0	None	-	1	Human	5.6	pKd	=	5.6	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1nc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	59456019	93950	0	None	-	1	Human	5.5	pKd	=	5.5	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	CHEMBL2326630	93950	0	None	-	1	Human	5.5	pKd	=	5.5	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	522	8	2	7	4.4	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1021/jm301572h
	9827294	80640	3	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	CHEMBL2018953	80640	3	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmc.2014.05.021
	9827294	80640	3	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	CHEMBL2018953	80640	3	None	-	1	Human	7.3	pKd	=	7.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1021/jm301572h
	59455975	93932	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	CHEMBL2326613	93932	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	518	8	3	7	4.3	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(C)O)cccc32)c1	10.1021/jm301572h
	59456010	93938	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	CHEMBL2326619	93938	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	574	9	2	8	4.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCOCC2)c1	10.1021/jm301572h
	118706817	119748	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310826	119748	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	387	4	3	4	3.0	COc1cc2[nH]c(=O)[nH]c2cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054387	93927	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326609	93927	0	None	-	1	Human	5.3	pKd	=	5.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	492	7	2	6	4.4	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(F)cccc32)c1	10.1021/jm301572h
	58054475	93943	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326623	93943	0	None	-	1	Human	6.3	pKd	=	6.3	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@H]2COCCN2)c1	10.1021/jm301572h
	10416	8660	30	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.ejmech.2016.02.058
	46861584	8660	30	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.ejmech.2016.02.058
	CHEMBL2018969	8660	30	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometryAntagonist activity at CCR4 in human PBMC assessed as inhibition of actin polymerization by flow cytometry	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.ejmech.2016.02.058
	10416	8660	30	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	46861584	8660	30	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	CHEMBL2018969	8660	30	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1021/jm301572h
	59456026	93951	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326631	93951	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1c(F)ccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	59456058	93953	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	CHEMBL2326633	93953	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	566	9	3	8	4.1	COc1cc(F)cc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)(C)O)c1	10.1021/jm301572h
	118706831	119762	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310841	119762	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	389	4	3	6	1.8	COc1nc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	58054384	93926	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	CHEMBL2326608	93926	0	None	-	1	Human	5.2	pKd	=	5.2	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	508	7	2	6	4.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(Cl)cccc32)c1	10.1021/jm301572h
	58054368	93944	0	None	-	1	Human	7.1	pKd	=	7.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	CHEMBL2326624	93944	0	None	-	1	Human	7.1	pKd	=	7.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	575	9	3	9	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)[C@@H]2COCCN2)c1	10.1021/jm301572h
	102143549	119760	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	CHEMBL3310839	119760	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometryAntagonist activity at CCR4 in human whole blood assessed as F-actin polymerization in CD4+ CCR4+ lymphocytes by phalloidin staining based flow cytometry	ChEMBL	388	4	3	5	2.4	COc1cc2[nH]c(=O)[nH]c2nc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.1016/j.bmc.2014.05.021
	136116031	93577	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	CHEMBL2321924	93577	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	490	7	3	7	3.9	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(O)cccc32)c1	10.1021/jm301572h
	59456111	93937	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	CHEMBL2326618	93937	0	None	-	1	Human	6.1	pKd	=	6.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	560	9	2	8	4.4	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C2CCCO2)c1	10.1021/jm301572h
	59456012	93934	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	CHEMBL2326615	93934	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Antagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysisAntagonist activity at CCR4 receptor in human whole blood assessed as F-actin polymerization after 30 mins by FACS-based flow cytometric analysis	ChEMBL	524	8	2	6	5.2	CC(=O)NCc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(C(F)F)cccc32)c1	10.1021/jm301572h
	9827294	80640	3	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018953	80640	3	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	499	5	2	7	3.7	O=C([C@H]1CCCCN1)N1CCN(c2nc(NCc3ccc(Cl)cc3Cl)c3cccnc3n2)CC1	10.1016/j.bmcl.2012.02.104
	127047356	146412	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797662	146412	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	1	6	4.5	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(CC4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	127045756	146647	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799266	146647	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	71462571	89345	3	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to CCR4Binding affinity to CCR4	ChEMBL	506	8	3	8	3.5	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(NC(=O)CO)c1	10.1021/jm300682j
	CHEMBL2178575	89345	3	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to CCR4Binding affinity to CCR4	ChEMBL	506	8	3	8	3.5	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(NC(=O)CO)c1	10.1021/jm300682j
	10416	8660	30	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	46861584	8660	30	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	CHEMBL2018969	8660	30	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	10.1016/j.bmcl.2012.02.104
	127047973	146543	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	496	5	1	6	4.9	O=C(c1ccccn1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798539	146543	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	496	5	1	6	4.9	O=C(c1ccccn1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127045977	146761	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799904	146761	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59455974	80649	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018961	80649	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	462	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CN)c1	10.1016/j.bmcl.2012.02.104
	16747697	100303	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246334	100303	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	71457815	90760	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	3.8	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207091	90760	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	3.8	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	71214976	90771	0	None	-79	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.5	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207101	90771	0	None	-79	3	Human	6.0	pKi	=	6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.5	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2012.09.020
	44440045	100367	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	443	6	1	4	3.2	CC(C)CN1CCC(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246584	100367	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	443	6	1	4	3.2	CC(C)CN1CCC(NC(=O)[C@@H]2CCCN2S(=O)(=O)c2ccc3ccccc3c2)CC1	10.1016/j.bmcl.2007.03.030
	44440043	173646	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	469	7	1	4	3.7	CC(C)c1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2007.03.030
	CHEMBL428576	173646	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	469	7	1	4	3.7	CC(C)c1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)NC2CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2007.03.030
	176	7186	66	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	7186	66	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	7186	66	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	7186	66	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	7186	66	None	-6	31	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	59456102	80652	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018964	80652	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(C)=O)c1	10.1016/j.bmcl.2012.02.104
	127046413	146894	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	462	6	2	6	3.4	CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797946	146894	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	462	6	2	6	3.4	CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3800702	146894	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	462	6	2	6	3.4	CNCC(=O)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59455992	80644	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018957	80644	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	71461439	90756	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207087	90756	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1	10.1016/j.bmcl.2012.09.020
	71452487	90757	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207088	90757	0	None	-12	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	382	5	1	5	3.4	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1	10.1016/j.bmcl.2012.09.020
	58054487	80651	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018963	80651	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	7	1	7	4.3	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(=O)N(C)C)c1	10.1016/j.bmcl.2012.02.104
	44440051	156394	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL394714	156394	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	127045976	146609	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799025	146609	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C([C@H]1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59456051	80655	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018967	80655	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	520	9	3	8	3.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)CO)c1	10.1016/j.bmcl.2012.02.104
	16747697	100303	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assayDisplacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246334	100303	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assayDisplacement of mouse MDC from recombinant CCR4 receptor expressed in CHO cells coexpressing G-alpha-16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	44440041	100311	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	441	7	1	4	2.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)Cc1ccccc1	10.1016/j.bmcl.2007.03.030
	CHEMBL246384	100311	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	441	7	1	4	2.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)Cc1ccccc1	10.1016/j.bmcl.2007.03.030
	71450658	90767	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.7	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207098	90767	0	None	-15	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	450	5	1	5	4.7	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	59455973	80643	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccccc1Cn1nc(NS(=O)(=O)c2ccc(Cl)s2)c2c(OC)cccc21	10.1016/j.bmcl.2012.02.104
	CHEMBL2018956	80643	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccccc1Cn1nc(NS(=O)(=O)c2ccc(Cl)s2)c2c(OC)cccc21	10.1016/j.bmcl.2012.02.104
	58054491	80654	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(C)=O)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018966	80654	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	504	8	2	7	4.2	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CNC(C)=O)cc1	10.1016/j.bmcl.2012.02.104
	127046189	146399	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797567	146399	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	58054516	80646	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	CHEMBL2018959	80646	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	493	8	1	8	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1OC	10.1016/j.bmcl.2012.02.104
	15604497	90768	0	None	-79	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	432	5	1	7	3.0	Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207099	90768	0	None	-79	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	432	5	1	7	3.0	Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	11525206	142006	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	CHEMBL372399	142006	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	448	5	2	6	3.2	O=C([C@H]1CCCCN1)N1CCN(c2nccc(NCc3ccc(Cl)cc3Cl)n2)CC1	10.1016/j.ejmech.2016.02.058
	127046247	146394	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	2	6	4.8	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797537	146394	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	6	2	6	4.8	Clc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	44440135	100110	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	CHEMBL245319	100110	0	None	-	1	Human	4.7	pKi	=	4.7	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	44440081	100172	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	582	8	1	5	3.9	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(N)=O)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245730	100172	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	582	8	1	5	3.9	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(N)=O)CC1	10.1016/j.bmcl.2007.03.030
	127045978	146460	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797980	146460	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.4	O=C([C@H]1CCCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127045975	146508	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798263	146508	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	4.0	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127046787	146694	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	1	6	4.0	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(C(=O)C4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799514	146694	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	1	6	4.0	CN(Cc1ccc(Cl)cc1Cl)c1ccnc(N2CCC3(CCN(C(=O)C4CCCN4)C3)CC2)n1	10.1016/j.ejmech.2016.02.058
	127046613	146751	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	456	5	2	6	2.9	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(F)cc4F)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799865	146751	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	456	5	2	6	2.9	O=C(C1CCCN1)N1CCC2(CCN(c3nccc(NCc4ccc(F)cc4F)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	44440031	156282	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	427	6	1	3	4.6	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	CHEMBL394642	156282	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	427	6	1	3	4.6	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	70689680	80642	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018955	80642	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	433	6	1	6	4.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1	10.1016/j.bmcl.2012.02.104
	59456072	80645	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018958	80645	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	1	7	4.6	COc1ccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)cc1	10.1016/j.bmcl.2012.02.104
	70681287	80648	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	CHEMBL2018960	80648	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccccc1CO	10.1016/j.bmcl.2012.02.104
	71461438	90751	0	None	-251	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207082	90751	0	None	-251	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	71461440	90766	0	None	-79	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	400	5	1	5	3.6	O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207097	90766	0	None	-79	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	400	5	1	5	3.6	O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	44440072	100304	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	557	7	0	4	5.0	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2F)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246335	100304	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	557	7	0	4	5.0	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2F)CC1	10.1016/j.bmcl.2007.03.030
	44440047	100368	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1cccc2ccccc12)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246585	100368	0	None	-	1	Human	4.6	pKi	=	4.6	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	491	6	0	4	4.1	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1cccc2ccccc12)C1CCN(Cc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	44440083	157590	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	554	7	1	5	4.4	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2N)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL395680	157590	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	554	7	1	5	4.4	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2N)CC1	10.1016/j.bmcl.2007.03.030
	44440059	100299	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	553	8	0	4	5.2	CCN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246328	100299	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	553	8	0	4	5.2	CCN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	9959269	80641	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	CHEMBL2018954	80641	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.ejmech.2016.02.058
	127046614	146704	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799578	146704	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	442	6	2	6	3.4	Fc1ccc(CNc2ccnc(N3CCC4(CCN(CC5CCCN5)C4)CC3)n2)c(F)c1	10.1016/j.ejmech.2016.02.058
	9959269	80641	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	CHEMBL2018954	80641	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	550	11	1	8	3.9	COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c2ccc(C)cc2)cc1OCCN(C)C	10.1016/j.bmcl.2012.02.104
	127046612	146528	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798452	146528	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127046412	146892	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	391	4	2	5	4.0	Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797678	146892	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	391	4	2	5	4.0	Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3800700	146892	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	391	4	2	5	4.0	Clc1ccc(CNc2ccnc(N3CCC4(CCNC4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	58054532	80650	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018962	80650	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	490	7	2	7	4.0	CNC(=O)c1cccc(Cn2nc(NS(=O)(=O)c3ccc(Cl)s3)c3c(OC)cccc32)c1	10.1016/j.bmcl.2012.02.104
	71456007	90761	0	None	-1	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	373	5	1	6	2.7	N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207092	90761	0	None	-1	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	373	5	1	6	2.7	N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1	10.1016/j.bmcl.2012.09.020
	71456008	90764	0	None	-50	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	404	5	1	6	4.0	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12	10.1016/j.bmcl.2012.09.020
	CHEMBL2207095	90764	0	None	-50	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	404	5	1	6	4.0	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12	10.1016/j.bmcl.2012.09.020
	70685473	80638	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018951	80638	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CO)c1	10.1016/j.bmcl.2012.02.104
	59456003	80639	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018952	80639	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	476	7	2	7	3.7	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(C(N)=O)c1	10.1016/j.bmcl.2012.02.104
	15985912	90750	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207081	90750	0	None	-2	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	71450657	90763	0	None	-15	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207094	90763	0	None	-15	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1	10.1016/j.bmcl.2012.09.020
	71452488	90762	0	None	-79	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	388	5	1	6	3.5	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207093	90762	0	None	-79	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	388	5	1	6	3.5	O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	44440076	158185	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2cccc(Cl)c2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL396166	158185	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2cccc(Cl)c2)CC1	10.1016/j.bmcl.2007.03.030
	44440084	100212	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	607	7	0	4	5.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(F)(F)F)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245931	100212	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	607	7	0	4	5.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(F)(F)F)CC1	10.1016/j.bmcl.2007.03.030
	3117	214620	103	None	-4	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	214620	103	None	-4	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	44440075	100112	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2Cl)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245331	100112	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2Cl)CC1	10.1016/j.bmcl.2007.03.030
	44440028	100653	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	CHEMBL247976	100653	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	477	6	1	4	3.8	O=C(NC1CCN(Cc2ccccc2)CC1)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1	10.1016/j.bmcl.2007.03.030
	44440079	100139	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	569	8	0	5	4.8	COc1cccc(CCN2CCC(N(C)C(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc4c(Cl)cccc4c3)CC2)c1	10.1016/j.bmcl.2007.03.030
	CHEMBL245531	100139	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	569	8	0	5	4.8	COc1cccc(CCN2CCC(N(C)C(=O)[C@@H]3CCCN3S(=O)(=O)c3ccc4c(Cl)cccc4c3)CC2)c1	10.1016/j.bmcl.2007.03.030
	127047612	146670	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	CHEMBL3799393	146670	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	474	6	2	6	4.4	Clc1ccc(CNc2ccnc(N3CCC4(CCN(C[C@H]5CCCN5)C4)CC3)n2)c(Cl)c1	10.1016/j.ejmech.2016.02.058
	127047970	146600	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.2	O=C(C1CCCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798949	146600	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	502	5	2	6	4.2	O=C(C1CCCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	127046191	146893	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	3.8	O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3798941	146893	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	3.8	O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3800701	146893	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	488	5	2	6	3.8	O=C(C1CCNC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	70693879	80196	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	CHEMBL2016602	80196	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	463	7	2	7	4.1	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1ccc(CO)cc1	10.1016/j.bmcl.2012.02.104
	16747697	100303	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246334	100303	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human MDC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	539	7	0	4	4.8	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	71454246	90758	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	376	5	1	5	3.4	Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C	10.1016/j.bmcl.2012.09.020
	CHEMBL2207089	90758	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	376	5	1	5	3.4	Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C	10.1016/j.bmcl.2012.09.020
	71454248	90770	0	None	-39	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207100	90770	0	None	-39	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	422	5	1	6	4.1	O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1	10.1016/j.bmcl.2012.09.020
	44440080	160138	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	583	8	1	5	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(=O)O)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL397848	160138	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	583	8	1	5	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccccc2C(=O)O)CC1	10.1016/j.bmcl.2007.03.030
	44440054	100470	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	505	7	0	4	4.2	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL246986	100470	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	505	7	0	4	4.2	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	44440055	160132	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	519	8	0	4	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL397845	160132	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	519	8	0	4	4.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2ccccc2c1)C1CCN(CCCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	71214725	90752	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207083	90752	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	416	5	1	5	4.1	O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	71214710	90754	0	None	-39	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	431	5	1	6	3.6	Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	CHEMBL2207085	90754	0	None	-39	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to CCR4 by 35S-gamma-GTP membrane assayBinding affinity to CCR4 by 35S-gamma-GTP membrane assay	ChEMBL	431	5	1	6	3.6	Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2012.09.020
	127047972	146398	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	501	5	1	5	5.8	O=C(C1CCCCC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	CHEMBL3797555	146398	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting methodDisplacement of [125I]-TARC from human recombinant CCR4 expressed in CHO cell membranes by scintillation counting method	ChEMBL	501	5	1	5	5.8	O=C(C1CCCCC1)N1CCC2(CCN(c3nccc(NCc4ccc(Cl)cc4Cl)n3)CC2)C1	10.1016/j.ejmech.2016.02.058
	59456067	80656	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	CHEMBL2018968	80656	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPADisplacement of [125I]TARC from human CCR4 expressed in CHO membranes by SPA	ChEMBL	534	9	3	8	3.6	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(CNC(=O)C(C)O)c1	10.1016/j.bmcl.2012.02.104
	44440077	100113	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245332	100113	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	573	7	0	4	5.5	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(Cl)cccc2c1)C1CCN(CCc2ccc(Cl)cc2)CC1	10.1016/j.bmcl.2007.03.030
	44440065	100109	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	523	7	0	4	4.3	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(F)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	CHEMBL245313	100109	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assayDisplacement of human TARC from recombinant CCR4 receptor expressed in CHO cells co-expressing Galpha16 by FLIPR assay	ChEMBL	523	7	0	4	4.3	CN(C(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc2c(F)cccc2c1)C1CCN(CCc2ccccc2)CC1	10.1016/j.bmcl.2007.03.030
	10416	8660	30	None	-	1	Human	7.8	pIC50	=	7.8	Binding	IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.	Guide to Pharmacology	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	23409871
	46861584	8660	30	None	-	1	Human	7.8	pIC50	=	7.8	Binding	IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.	Guide to Pharmacology	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	23409871
	CHEMBL2018969	8660	30	None	-	1	Human	7.8	pIC50	=	7.8	Binding	IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.IC<sub>50</sub> determined in a GTPγS binding assay using membranes from CHO cells expressing human recombinant CCR4 receptor.	Guide to Pharmacology	548	9	3	8	4.0	COc1cccc2c1c(nn2Cc1cccc(c1)CNC(=O)C(O)(C)C)NS(=O)(=O)c1ccc(s1)Cl	23409871
	176	7186	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	7186	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	7186	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	7186	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	7186	66	None	-6	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	3117	214620	103	None	-4	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	CHEMBL964	214620	103	None	-4	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)DRUGMATRIX: Chemokine CCR4 radioligand binding (ligand: [125I] TARC)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)