GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	71460332	87708	4	None	-181	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assayAntagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay	ChEMBL	429	7	1	3	6.2	C[C@H](NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(Cl)c2)cc1	10.1016/j.bmcl.2011.04.091
	CHEMBL2153446	87708	4	None	-181	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assayAntagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay	ChEMBL	429	7	1	3	6.2	C[C@H](NC(=O)CCCc1ccc2cccnc2n1)c1ccc(-c2cccc(Cl)c2)cc1	10.1016/j.bmcl.2011.04.091
	71456641	87735	0	None	-125	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assayAntagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay	ChEMBL	426	6	0	5	6.2	Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1	10.1016/j.bmcl.2011.04.091
	CHEMBL2153586	87735	0	None	-125	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assayAntagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay	ChEMBL	426	6	0	5	6.2	Clc1cccc(-c2ccc(-c3nnc(CCCc4ccc5cccnc5n4)o3)cc2)c1	10.1016/j.bmcl.2011.04.091
	71462027	87702	0	None	-173	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assayAntagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay	ChEMBL	415	7	1	3	5.6	O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(Cl)c2)cc1	10.1016/j.bmcl.2011.04.091
	CHEMBL2153440	87702	0	None	-173	3	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assayAntagonist activity at human GPR99 receptor expressed in CHO-K1 cells co-expressing Galpha and Gqi5 G-protein assessed as inhibition of succinate-induced increase in intracellular calcium level at by FLIPR assay	ChEMBL	415	7	1	3	5.6	O=C(CCCc1ccc2cccnc2n1)NCc1ccc(-c2cccc(Cl)c2)cc1	10.1016/j.bmcl.2011.04.091
	3636	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	15141213
	3636	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	23396314
	51	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	15141213
	51	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	23396314
	CHEMBL1686	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	15141213
	CHEMBL1686	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	23396314
	DB08845	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	15141213
	DB08845	7149	125	None	-22908	2	Human	3.9	pEC50	=	3.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	146	4	2	3	-0.5	OC(=O)CCC(=O)C(=O)O	23396314

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	46875342	208955	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	449	11	5	10	-0.4	CC(=O)NCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL609487	208955	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	449	11	5	10	-0.4	CC(=O)NCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875317	208753	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	414	3	4	9	0.1	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC23CC4CC(CC(C4)C2)C3)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL608000	208753	0	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	414	3	4	9	0.1	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC23CC4CC(CC(C4)C2)C3)[C@@H](O)[C@H]1O	10.1021/jm000150k
	10089226	86065	0	None	50	4	Rat	7.9	pKi	=	7.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	350	6	4	9	-0.7	CCCCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL2113492	86065	0	None	50	4	Rat	7.9	pKi	=	7.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	350	6	4	9	-0.7	CCCCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	10738295	84595	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.3	C[C@H]1CC[C@H](NC(=O)[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)CC1	10.1021/jm000150k
	CHEMBL2092859	84595	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.3	C[C@H]1CC[C@H](NC(=O)[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)CC1	10.1021/jm000150k
	46875267	208998	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	434	12	4	9	1.7	CCCCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL609768	208998	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	434	12	4	9	1.7	CCCCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875320	208754	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	430	6	4	11	-0.6	COc1ccc(CNC(=O)[C@H]2OC(n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1OC	10.1021/jm000150k
	CHEMBL608003	208754	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	430	6	4	11	-0.6	COc1ccc(CNC(=O)[C@H]2OC(n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1OC	10.1021/jm000150k
	46875266	208954	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	448	13	4	9	2.1	CCCCCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL609485	208954	0	None	-	1	Rat	6.8	pKi	=	6.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	448	13	4	9	2.1	CCCCCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	9996282	26261	0	None	-3	4	Rat	6.8	pKi	=	6.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	323	4	5	10	-2.9	NCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL129903	26261	0	None	-3	4	Rat	6.8	pKi	=	6.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	323	4	5	10	-2.9	NCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	49797674	208926	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	336	5	4	9	-1.1	CCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL609186	208926	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	336	5	4	9	-1.1	CCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	10316575	86062	0	None	141	4	Rat	7.8	pKi	=	7.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	362	3	4	9	-0.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL2113489	86062	0	None	141	4	Rat	7.8	pKi	=	7.8	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	362	3	4	9	-0.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	21152082	208717	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	364	7	4	9	-0.3	CCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL607719	208717	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	364	7	4	9	-0.3	CCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875402	208883	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	336	4	4	9	-1.1	CCC(C)NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL608895	208883	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	336	4	4	9	-1.1	CCC(C)NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	56668023	70036	0	None	44	3	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	291	2	4	9	-2.0	C#CC(O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL1791423	70036	0	None	44	3	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	291	2	4	9	-2.0	C#CC(O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875323	208793	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	352	5	4	10	-1.3	CC(C)CONC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL608293	208793	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	352	5	4	10	-1.3	CC(C)CONC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875257	208881	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	378	8	4	9	0.1	CCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL608888	208881	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	378	8	4	9	0.1	CCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875347	209001	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	414	3	4	9	-0.0	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2C3CC4CC(C3)CC2C4)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL609774	209001	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	414	3	4	9	-0.0	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2C3CC4CC(C3)CC2C4)[C@@H](O)[C@H]1O	10.1021/jm000150k
	46875326	208794	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	392	9	4	9	0.5	CCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL608296	208794	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	392	9	4	9	0.5	CCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875346	209000	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.1	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2CCCCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL609773	209000	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.1	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2CCCCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	46875336	208882	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	390	3	4	9	0.3	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2CCCCCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL608893	208882	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	390	3	4	9	0.3	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2CCCCCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	377	9534	53	None	-70	15	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	425	9534	53	None	-70	15	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	448222	9534	53	None	-70	15	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	CHEMBL464859	9534	53	None	-70	15	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	46875307	209394	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	420	11	4	9	1.3	CCCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL612154	209394	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	420	11	4	9	1.3	CCCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875349	209003	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	407	10	5	10	-0.6	NCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL609776	209003	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	407	10	5	10	-0.6	NCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	3044933	23255	6	None	-2	6	Rat	7.5	pKi	=	7.5	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	322	4	4	9	-1.4	CCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL1235128	23255	6	None	-2	6	Rat	7.5	pKi	=	7.5	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	322	4	4	9	-1.4	CCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875268	208999	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	406	10	4	9	0.9	CCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL609769	208999	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	406	10	4	9	0.9	CCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	377	9534	53	None	-70	15	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	425	9534	53	None	-70	15	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	448222	9534	53	None	-70	15	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	CHEMBL464859	9534	53	None	-70	15	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	308	3	4	9	-1.8	CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N	10.1021/jm000150k
	46875399	208830	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	296	2	5	10	-2.5	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NO)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL608595	208830	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	296	2	5	10	-2.5	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NO)[C@@H](O)[C@H]1O	10.1021/jm000150k
	21152084	208716	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	370	4	4	9	-0.7	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NCc2ccccc2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL607717	208716	0	None	-	1	Rat	7.4	pKi	=	7.4	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	370	4	4	9	-0.7	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NCc2ccccc2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	46875348	209002	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	365	5	5	10	-2.7	CC(=O)NCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL609775	209002	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	365	5	5	10	-2.7	CC(=O)NCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	215610	83710	4	None	-1	6	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	348	3	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL2070508	83710	4	None	-1	6	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	348	3	4	9	-0.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	98567	198560	18	None	-4	7	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	294	2	4	9	-2.2	CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL519809	198560	18	None	-4	7	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	294	2	4	9	-2.2	CNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	10738295	84585	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.3	C[C@H]1CC[C@@H](NC(=O)[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)CC1	10.1021/jm000150k
	CHEMBL2092773	84585	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.3	C[C@H]1CC[C@@H](NC(=O)[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)CC1	10.1021/jm000150k
	3042985	86007	2	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	310	3	4	10	-2.3	CONC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL2113434	86007	2	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	310	3	4	10	-2.3	CONC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	25244925	208401	0	None	1	3	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	280	2	4	9	-2.5	NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL605866	208401	0	None	1	3	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	280	2	4	9	-2.5	NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875400	208831	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	374	3	4	9	-0.7	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2CC3CCC2C3)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL608596	208831	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	374	3	4	9	-0.7	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC2CC3CCC2C3)[C@@H](O)[C@H]1O	10.1021/jm000150k
	46875327	208827	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	324	4	4	10	-1.9	CCONC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL608587	208827	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	324	4	4	10	-1.9	CCONC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	10735584	86009	0	None	-5	4	Rat	5.2	pKi	=	5.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	336	2	4	9	-1.1	CC(C)(C)NC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL2113436	86009	0	None	-5	4	Rat	5.2	pKi	=	5.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	336	2	4	9	-1.1	CC(C)(C)NC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875331	208828	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.3	CC1CCCCC1NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	CHEMBL608591	208828	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	376	3	4	9	-0.3	CC1CCCCC1NC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm000150k
	46875260	208925	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	400	3	4	9	-0.3	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC23CC4CC(C2)C(C4)C3)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL609179	208925	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	400	3	4	9	-0.3	Nc1ncnc2c1ncn2C1O[C@H](C(=O)NC23CC4CC(C2)C(C4)C3)[C@@H](O)[C@H]1O	10.1021/jm000150k
	10449535	83709	0	None	-15	6	Rat	7.1	pKi	=	7.1	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	334	3	4	9	-1.3	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL2070507	83709	0	None	-15	6	Rat	7.1	pKi	=	7.1	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	334	3	4	9	-1.3	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CCC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	10403711	103108	33	None	-50	9	Rat	7.0	pKi	=	7.0	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	320	3	4	9	-1.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	CHEMBL261482	103108	33	None	-50	9	Rat	7.0	pKi	=	7.0	Binding	Binding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranesBinding activity of P3 purinoceptor-like protein (P3LP) using radioligand 40 nM [3H]NECA from rat brain membranes	ChEMBL	320	3	4	9	-1.7	Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)NC2CC2)[C@@H](O)[C@H]1O	10.1021/jm000150k
	3352	9150	28	None	15	3	Mouse	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	23504326
	5280879	9150	28	None	15	3	Mouse	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	23504326
	5863	9150	28	None	15	3	Mouse	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	23504326
	CHEMBL509456	9150	28	None	15	3	Mouse	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	439	18	4	5	4.3	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N	23504326

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Main reference

Ligand source activities (1 row/activity)