Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 77846754 | 182648 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 435 | 5 | 1 | 3 | 6.3 | Cc1cc(OC2CCC3(CCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| CHEMBL4787458 | 182648 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 435 | 5 | 1 | 3 | 6.3 | Cc1cc(OC2CCC3(CCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| 77846502 | 180746 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 423 | 6 | 2 | 3 | 6.1 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| CHEMBL4754965 | 180746 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 423 | 6 | 2 | 3 | 6.1 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| 12573 | 995 | None | 2 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | ||
| 77846592 | 995 | None | 2 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | ||
| CHEMBL4748198 | 995 | None | 2 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | ||
| 77847762 | 183529 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 397 | 7 | 2 | 3 | 5.7 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| CHEMBL4798593 | 183529 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 397 | 7 | 2 | 3 | 5.7 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| 77846503 | 182416 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 451 | 6 | 2 | 3 | 6.9 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| CHEMBL4784199 | 182416 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 451 | 6 | 2 | 3 | 6.9 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligandAgonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | ||
| 25192001 | 8061 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -2 | 4 | Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay |
ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| CHEMBL1091103 | 8061 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -2 | 4 | Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay |
ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | ||
| 11502996 | 158819 | None | 36 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -11 | 3 | Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by ELISAAgonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by ELISA |
ChEMBL | 435 | 9 | 1 | 4 | 5.0 | CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | ||
| CHEMBL4093489 | 158819 | None | 36 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -11 | 3 | Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by ELISAAgonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by ELISA |
ChEMBL | 435 | 9 | 1 | 4 | 5.0 | CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | Agonist activity at human S1P5RAgonist activity at human S1P5R |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/ml100301k | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | Agonist activity at human S1P5RAgonist activity at human S1P5R |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/ml100301k | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | Agonist activity at human S1P5RAgonist activity at human S1P5R |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/ml100301k | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayAgonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | Agonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.0c00631 | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | Agonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.0c00631 | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | Agonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assayAgonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.0c00631 | ||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | Agonist activity at human S1P5 receptor by GTPgammaS binding assayAgonist activity at human S1P5 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | Agonist activity at human S1P5 receptor by GTPgammaS binding assayAgonist activity at human S1P5 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | Agonist activity at human S1P5 receptor by GTPgammaS binding assayAgonist activity at human S1P5 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | Agonist activity at human S1P5 receptor by GTPgammaS binding assayAgonist activity at human S1P5 receptor by GTPgammaS binding assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | ||
| 11222939 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -9 | 4 | Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | ||
| 44438254 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -9 | 4 | Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | ||
| CHEMBL190006 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -9 | 4 | Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingAgonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | ||
| 46881623 | 6765 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 5 | 3 | Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayAgonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assay |
ChEMBL | 477 | 9 | 2 | 6 | 4.1 | Cc1cc(CN2CC(C(=O)O)C2)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | ||
| CHEMBL1083828 | 6765 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 5 | 3 | Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayAgonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assay |
ChEMBL | 477 | 9 | 2 | 6 | 4.1 | Cc1cc(CN2CC(C(=O)O)C2)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | ||
| 59384310 | 104446 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 3 | Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting |
ChEMBL | 511 | 13 | 3 | 7 | 5.2 | CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F | 10.1021/ml400194r | ||
| CHEMBL3102904 | 104446 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 3 | Agonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation countingAgonist activity at human S1P5R expressed in HEK293T cells assessed as [35S]GTPgammaS binding after 30 mins by scintillation counting |
ChEMBL | 511 | 13 | 3 | 7 | 5.2 | CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F | 10.1021/ml400194r | ||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 6 | Agonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | ||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 6 | Agonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | ||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 6 | Agonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assayAgonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | ||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | Agonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting methodAgonist activity at recombinant human S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting method |
ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | ||
| 44412994 | 78351 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -7 | 3 | Agonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptakeAgonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptake |
ChEMBL | 499 | 7 | 1 | 6 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C(F)(F)F)C(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | ||
| CHEMBL210942 | 78351 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -7 | 3 | Agonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptakeAgonist activity at S1P5 receptor expressed in CHO cells measured as S1P-induced [35S]GTP-gamma-S uptake |
ChEMBL | 499 | 7 | 1 | 6 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C(F)(F)F)C(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | ||
| 77846505 | 180122 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 437 | 6 | 2 | 3 | 6.5 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| CHEMBL4747262 | 180122 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | Antagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assayAntagonist activity at recombinant human S1P5 receptor expressed in Chem-1 cells assessed as EC80 S1P-induced calcium flux measured for 180 secs by FLIPR assay |
ChEMBL | 437 | 6 | 2 | 3 | 6.5 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | ||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -2 | 15 | Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayActivity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assay |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | ||
Showing 1 to 50 of 713 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingDisplacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation counting |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | ||
| 107970 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P5 receptor (unknown origin)Agonist activity at S1P5 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 107970.0 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P5 receptor (unknown origin)Agonist activity at S1P5 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 2407 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P5 receptor (unknown origin)Agonist activity at S1P5 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 4167 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P5 receptor (unknown origin)Agonist activity at S1P5 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| CHEMBL314854 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P5 receptor (unknown origin)Agonist activity at S1P5 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| DB08868 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | Agonist activity at S1P5 receptor (unknown origin)Agonist activity at S1P5 receptor (unknown origin) |
ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | ||
| 49868651 | 171251 | None | 1 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 542 | 8 | 2 | 8 | 5.3 | O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| CHEMBL4458575 | 171251 | None | 1 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 542 | 8 | 2 | 8 | 5.3 | O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| 50925337 | 170555 | None | 14 | Human | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 528 | 7 | 2 | 8 | 4.9 | O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| CHEMBL4448752 | 170555 | None | 14 | Human | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | Agonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assayAgonist activity at S1P5 receptor (unknown origin) measured after 45 mins by [35S]GTP-gammaS binding assay |
ChEMBL | 528 | 7 | 2 | 8 | 4.9 | O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | ||
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand |
ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | ||
| 134130131 | 142374 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3885151 | 142374 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 | 10.1016/j.bmcl.2016.11.050 | ||
| 46174905 | 116352 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayAgonist activity at human S1P5 receptor by beta-arrestin recruitment assay |
ChEMBL | 457 | 6 | 1 | 3 | 6.9 | O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 | 10.1021/ml500422m | ||
| CHEMBL3358955 | 116352 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | Agonist activity at human S1P5 receptor by beta-arrestin recruitment assayAgonist activity at human S1P5 receptor by beta-arrestin recruitment assay |
ChEMBL | 457 | 6 | 1 | 3 | 6.9 | O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 | 10.1021/ml500422m | ||
| 134129958 | 142367 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3885074 | 142367 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | ||
| 44342468 | 12122 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL1184089 | 12122 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL332050 | 12122 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| 11682677 | 11786 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assay |
ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| CHEMBL1181748 | 11786 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assay |
ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| CHEMBL190865 | 11786 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assay |
ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| 44342231 | 12104 | None | 2 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 408 | 19 | 4 | 4 | 4.0 | CCCCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL1183950 | 12104 | None | 2 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 408 | 19 | 4 | 4 | 4.0 | CCCCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL325408 | 12104 | None | 2 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 408 | 19 | 4 | 4 | 4.0 | CCCCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
| 134131071 | 142208 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3883377 | 142208 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| 134130884 | 142237 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3883572 | 142237 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | ||
| 134131188 | 142385 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 354 | 7 | 3 | 4 | 3.6 | CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3885229 | 142385 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 354 | 7 | 3 | 4 | 3.6 | CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | ||
| 44398049 | 13183 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assay |
ChEMBL | 441 | 13 | 5 | 5 | 3.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| CHEMBL1190950 | 13183 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assay |
ChEMBL | 441 | 13 | 5 | 5 | 3.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| CHEMBL541890 | 13183 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assayEffective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assay |
ChEMBL | 441 | 13 | 5 | 5 | 3.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | ||
| 44342331 | 11420 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL116953 | 11420 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL1180214 | 11420 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | ||
| 44342244 | 64897 | None | 2 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL182164 | 64897 | None | 2 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
| CHEMBL423691 | 64897 | None | 2 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligandIn vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells using [gamma-35S]-GTP as radioligand |
ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | ||
| 134130571 | 142304 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 | 10.1016/j.bmcl.2016.11.050 | ||
| CHEMBL3884292 | 142304 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting methodAgonist activity at recombinant human S1PR5 expressed in CHO cell membranes assessed as [35S]GTP-gammaS binding measured after 1.5 hrs by TopCount scintillation counting method |
ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 | 10.1016/j.bmcl.2016.11.050 | ||
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