Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
10327 10232 65 None - 1 Human 5.6 pKd = 5.6 Binding
Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.
Guide to Pharmacology 489 6 1 4 6.8 CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 31964872
5284330 10232 65 None - 1 Human 5.6 pKd = 5.6 Binding
Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.
Guide to Pharmacology 489 6 1 4 6.8 CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 31964872
CHEMBL1221983 10232 65 None - 1 Human 5.6 pKd = 5.6 Binding
Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.
Guide to Pharmacology 489 6 1 4 6.8 CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 31964872