Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
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Sel. page | Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
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| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
| 10327 | 3459 | None | 52 | Human | Binding | pKd | = | 5.6 | 5.6 | - | 1 | Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression. |
Guide to Pharmacology | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 31964872 | ||
| 5284330 | 3459 | None | 52 | Human | Binding | pKd | = | 5.6 | 5.6 | - | 1 | Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression. |
Guide to Pharmacology | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 31964872 | ||
| CHEMBL1221983 | 3459 | None | 52 | Human | Binding | pKd | = | 5.6 | 5.6 | - | 1 | Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression. |
Guide to Pharmacology | 489 | 6 | 1 | 4 | 6.8 | CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 | 31964872 | ||
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