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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Ala³¹,Aib³²]NPY	335	None	0	Rat	Binding	pKi	None	-	8.40	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12890716
[D-Trp³²]NPY	1500	None	0	Human	Binding	pKi	None	-	8.10	-1	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8824284
[D-Trp³²]NPY	1500	None	0	Rat	Binding	pKi	None	-	8.20	1	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8824284
[Leu³¹,Pro³⁴]NPY (pig)	2303	None	0	Human	Binding	pKi	None	-	9.10	1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8824284
[Leu³¹,Pro³⁴]NPY (pig)	2303	None	0	Rat	Binding	pKi	None	-	8.95	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8824284
[Leu³¹,Pro³⁴]NPY (pig)	2303	None	0	Rat	Binding	pKi	None	-	8.95	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12890716
[Leu³¹,Pro³⁴]PYY (human)	2304	None	0	Human	Binding	pKi	=	-	8.80	-25	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8824284
[Leu³¹,Pro³⁴]PYY (human)	2304	None	0	Rat	Binding	pKi	None	-	8.70	-31	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8824284
[PP_1-17,Ala³¹,Aib³²]NPY (human)	3155	None	0	Human	Binding	pKi	None	-	8.80	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12890716
ATC0175	511	None	14	Human	Binding	IC50	=	2700.00	5.57	-	7	Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cells	ChEMBL	425.2	5	2	5	4.13	CN(C)c1nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)c(F)c3)CC2)nc2ccccc12	https://dx.doi.org/10.1016/j.bmcl.2005.05.121
BENEXTRAMINE	67670	None	3	Human	Binding	Ki	=	5000.00	5.30	-2	2	Binding affinity to NPY5 receptor	ChEMBL	590.4	27	4	8	6.26	COc1ccccc1CNCCCCCCNCCSSCCNCCCCCCNCc1ccccc1OC	https://dx.doi.org/10.1016/j.bmcl.2011.06.124
BIBO3304	630	None	18	Rat	Binding	IC50	=	21000.00	4.68	-	4	Radioligand binding assay (rat NPY5R, CHO cells)	ChEMBL	529.3	13	6	4	1.84	NC(=O)NCc1ccc(CNC(=O)[C@@H](CCCN=C(N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1	https://dx.doi.org/10.6019/CHEMBL5463723
BIBO3304	218915	125I-hPP	0	Rat	Binding	pKi	=	1000.00	6.00	-	1	-	PDSP KiDatabase	643.3	13	7	5	2.48	NC(=O)NCc1ccc(CNC(=O)C(CCCN=C(N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1.O=C(O)C(F)(F)F	-
BIIE0246	218722	125I-hPP	0	Rat	Binding	pKi	=	1000.00	6.00	-131	3	-	PDSP KiDatabase	895.4	16	5	11	3.29	NC(N)=NCCCC(NC(=O)CC1(CC(=O)N2CCN(C3c4ccccc4NC(=O)c4ccccc43)CC2)CCCC1)C(=O)NCCn1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O	-
CGP 71683A	899	None	11	Human	Binding	IC50	=	1.30	8.89	-	8	Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 transiently expressed in COS-1 cells using [125I]PYY	ChEMBL	475.2	7	3	6	4.56	Nc1nc(NCC2CCC(CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12	https://dx.doi.org/10.1016/j.bmcl.2005.03.052
CGP 71683A	899	None	11	Human	Binding	IC50	=	2.90	8.54	-	8	Compound was tested for human Neuropeptide Y receptor type 5	ChEMBL	475.2	7	3	6	4.56	Nc1nc(NCC2CCC(CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12	https://dx.doi.org/10.1016/s0960-894x(00)00177-3
CGP 71683A	899	None	11	Human	Binding	IC50	=	2.90	8.54	-	8	Human Neuropeptide Y5 receptor binding affinity	ChEMBL	475.2	7	3	6	4.56	Nc1nc(NCC2CCC(CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12	https://dx.doi.org/10.1016/j.bmcl.2003.11.070
CGP 71683A	899	None	11	Rat	Binding	pKi	None	-	9.50	2	8	Unclassified	Guide to Pharmacology	475.2	7	3	6	4.56	Nc1nc(NCC2CCC(CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12	https://pubmed.ncbi.nlm.nih.gov/12890716
CGP 71683A	899	125I-hPP	11	Rat	Binding	pKi	=	1.10	8.96	2	8	-	PDSP KiDatabase	475.2	7	3	6	4.56	Nc1nc(NCC2CCC(CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12	-
CGP 71683A	899	None	11	Rat	Binding	IC50	=	1.40	8.85	2	8	Compound was tested for rat Neuropeptide Y receptor type 5	ChEMBL	475.2	7	3	6	4.56	Nc1nc(NCC2CCC(CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12	https://dx.doi.org/10.1016/s0960-894x(00)00177-3

Showing 1 to 20 of 1,413 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Ala³¹,Aib³²]NPY (pig)	336	None	0	Human	Functional	pIC50	=	-	8.20	1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12069595
[Ala³¹,Aib³²]NPY (pig)	336	None	0	Rat	Functional	pIC50	=	-	8.20	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/12069595
CGP 71683A	899	None	11	Human	Functional	IC50	=	2.90	8.54	-1	8	Compound was tested for its antagonistic activity against Neuropeptide Y receptor Y5 subtype stably expressed in LM(tk-)cells	ChEMBL	475.2	7	3	6	4.56	Nc1nc(NCC2CCC(CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12	https://dx.doi.org/10.1016/s0960-894x(00)00177-3
CHEMBL1208795	14974	None	0	Human	Functional	Ki	=	50.12	7.30	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	377.1	5	1	6	3.03	O=C(c1ccncc1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1208996	14988	None	0	Human	Functional	Ki	=	2511.89	5.60	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	314.1	4	1	5	2.34	CC(=O)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209049	14994	None	0	Human	Functional	Ki	=	2.51	8.60	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	342.2	5	1	5	2.98	CC(C)C(=O)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209050	14995	None	0	Human	Functional	Ki	=	12.59	7.90	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	376.1	5	1	5	3.63	O=C(c1ccccc1)N1C[C@H]2[C@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209051	14996	None	0	Human	Functional	Ki	=	2.51	8.60	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	376.1	5	1	5	3.63	O=C(c1ccccc1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209052	14997	None	0	Human	Functional	Ki	=	1.00	9.00	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	394.1	5	1	5	3.77	O=C(c1cccc(F)c1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209053	14998	None	0	Human	Functional	Ki	=	1.58	8.80	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	412.1	5	1	5	3.91	O=C(c1cc(F)cc(F)c1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209100	15003	None	0	Human	Functional	Ki	=	5.01	8.30	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	377.1	5	1	6	3.03	O=C(c1cccnc1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209101	15004	None	0	Human	Functional	Ki	=	1.00	9.00	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	390.2	6	1	5	3.56	O=C(Cc1ccccc1)N1C[C@H]2[C@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209102	15005	None	0	Human	Functional	Ki	=	1.00	9.00	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	390.2	6	1	5	3.56	O=C(Cc1ccccc1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209159	15015	None	0	Human	Functional	Ki	=	0.40	9.40	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	404.2	6	1	5	4.13	CC(C(=O)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1)c1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209160	15016	None	0	Human	Functional	Ki	=	0.79	9.10	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	416.2	6	1	5	4.05	O=C(N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1)C1(c2ccccc2)CC1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209161	15017	None	0	Human	Functional	Ki	=	6.31	8.20	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	404.2	7	1	5	3.95	O=C(CCc1ccccc1)N1C[C@H]2[C@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209162	15018	None	0	Human	Functional	Ki	=	0.63	9.20	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	404.2	7	1	5	3.95	O=C(CCc1ccccc1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209215	15028	None	0	Human	Functional	Ki	=	5.01	8.30	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	432.2	7	1	5	4.76	CC(C(=O)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1)C(C)c1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209216	15029	None	0	Human	Functional	Ki	=	0.79	9.10	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	416.2	6	1	5	4.13	O=C([C@H]1C[C@@H]1c1ccccc1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140
CHEMBL1209217	15030	None	0	Human	Functional	Ki	=	7.94	8.10	-	1	Antagonist activity at human NPY Y5 receptor expressed in HEK293 cells assessed as inhibition of calcium level by FLIPR assay	ChEMBL	370.1	5	1	6	2.36	O=C(C1CCOC1)N1C[C@H]2[C@@H](CNc3nc(-c4ccccn4)cs3)[C@H]2C1	https://dx.doi.org/10.1016/j.bmcl.2010.06.140

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Ligand source activities (1 row/activity)