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Ligand source activities (1 row/activity)

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Potency

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

4-BENZENESULFINYLMETHYL-1-[2-(5-FLUORO-1H-INDOL-3-YL)-ETHYL]-PIPERIDIN-4-OL (STRUCTURAL MIX)	203249	None	1	Human	Binding	IC50	=	22.00	7.66	-	2	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	400.2	6	2	3	3.48	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	https://dx.doi.org/10.1016/s0960-894x(01)00074-9
4-BENZENESULFINYLMETHYL-1-[2-(5-FLUORO-1H-INDOL-3-YL)-ETHYL]-PIPERIDIN-4-OL (STRUCTURAL MIX)	203249	None	1	Rat	Binding	Ki	=	7.94	8.10	-	2	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400.2	6	2	3	3.48	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	https://dx.doi.org/10.1016/S0960-894X(01)80541-2
4-BENZENESULFINYLMETHYL-1-[2-(5-FLUORO-1H-INDOL-3-YL)-ETHYL]-PIPERIDIN-4-OL (STRUCTURAL MIX)	203249	None	1	Rat	Binding	Ki	=	0.50	9.30	-	2	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400.2	6	2	3	3.48	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	https://dx.doi.org/10.1016/S0960-894X(01)80541-2
4-NONYLPHENOL	45775	None	35	Human	Binding	IC50	=	4514.00	5.34	-1	5	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	220.2	8	1	1	4.68	CCCCCCCCCc1ccc(O)cc1	-
4-NONYLPHENOL	45775	None	35	Human	Binding	Ki	=	1505.00	5.82	-1	5	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	220.2	8	1	1	4.68	CCCCCCCCCc1ccc(O)cc1	-
4-OCTYLPHENOL	71142	None	57	Human	Binding	IC50	=	17430.00	4.76	-2	10	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	206.2	7	1	1	4.29	CCCCCCCCc1ccc(O)cc1	-
4-OCTYLPHENOL	71142	None	57	Human	Binding	Ki	=	5810.00	5.24	-2	10	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	206.2	7	1	1	4.29	CCCCCCCCc1ccc(O)cc1	-
[βAla⁸]neurokinin A-(4-10)	604	None	0	Human	Binding	pKd	=	-	6.00	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/7682062
[Phe(Me)⁷]neurokinin B	3094	None	0	Human	Binding	pKi	None	-	6.90	-199	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9190866
A-85380	218616	125I-Neurokinin A	0	Human	Binding	pKi	=	10000.00	5.00	-1	13	-	PDSP KiDatabase	164.1	3	1	3	0.82	c1cncc(OCC2CCN2)c1	-
ABT-418	218617	125I-Neurokinin A	0	Human	Binding	pKi	=	10000.00	5.00	-1	8	-	PDSP KiDatabase	166.1	1	0	3	1.75	Cc1cc(C2CCCN2C)on1	-
ABT-594	219818	125I-NKA	0	Human	Binding	pKi	=	1000.00	6.00	-2	37	-	PDSP KiDatabase	198.1	3	1	3	1.48	Clc1ccc(OCC2CCN2)cn1	-
ALPHA-NAPHTHOFLAVONE	99541	None	62	Human	Binding	IC50	=	5847.10	5.23	-2	5	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	272.1	1	0	2	4.61	O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12	-
ALPHA-NAPHTHOFLAVONE	99541	None	62	Human	Binding	Ki	=	1949.00	5.71	-2	5	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	272.1	1	0	2	4.61	O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12	-
amiodarone	398	None	47	Human	Binding	pKi	=	5.19	8.28	-4	40	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	645.0	11	0	4	6.94	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1	-
amiodarone	398	None	47	Human	Binding	IC50	=	19315.00	4.71	-4	40	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645.0	11	0	4	6.94	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1	-
amiodarone	398	None	47	Human	Binding	Ki	=	6438.00	5.19	-4	40	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645.0	11	0	4	6.94	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1	-
astemizole	505	None	55	Human	Binding	IC50	=	2986.00	5.53	-44	48	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458.2	8	1	5	5.35	COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	-
astemizole	505	None	55	Human	Binding	pKi	=	6.00	8.22	-44	48	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	458.2	8	1	5	5.35	COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	-
astemizole	505	None	55	Human	Binding	Ki	=	995.00	6.00	-44	48	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458.2	8	1	5	5.35	COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	-

Showing 1 to 20 of 1,364 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

[Lys⁵,Me-Leu⁹,Nle¹⁰]NKA-(4-10)	2437	None	0	Rat	Functional	pIC50	=	-	9.10	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9718274
cefapirin	220190	None	0	Human	Functional	pIC50	=	4.85	8.31	-1	14	None	Drug Central	423.1	7	2	8	0.47	CC(=O)OCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)CSc3ccncc3)[C@H]2SC1	-
CHEMBL100297	4219	None	0	Human	Functional	Kd	=	10.00	8.00	-	1	Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2	ChEMBL	607.3	12	2	4	6.09	CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	https://dx.doi.org/10.1016/s0960-894x(02)00539-5
CHEMBL100298	4220	None	1	Human	Functional	Kd	=	3.98	8.40	-	1	Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2	ChEMBL	736.4	16	2	6	6.90	O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	https://dx.doi.org/10.1016/s0960-894x(02)00539-5
CHEMBL1083850	6773	None	0	Human	Functional	Kd	=	0.20	9.70	-	1	Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions	ChEMBL	630.4	12	2	6	5.80	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	https://dx.doi.org/10.1021/jm100176s
CHEMBL110219	9175	None	0	Golden hamster	Functional	Kd	=	316.23	6.50	-	4	Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.	ChEMBL	592.2	7	1	4	5.89	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1	https://dx.doi.org/10.1016/s0960-894x(02)00645-5
CHEMBL121271	15274	None	0	Golden hamster	Functional	Kd	=	1.62	8.79	-	2	Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	828.4	11	8	7	3.08	CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	https://dx.doi.org/10.1021/jm00047a020
CHEMBL121271	15274	None	0	Rabbit	Functional	Kd	=	42.66	7.37	-	2	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	828.4	11	8	7	3.08	CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	https://dx.doi.org/10.1021/jm00047a020
CHEMBL121571	15460	None	0	Golden hamster	Functional	Kd	=	12.88	7.89	-	2	Tested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	762.4	12	8	8	1.44	CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	https://dx.doi.org/10.1021/jm00047a020
CHEMBL121571	15460	None	0	Rabbit	Functional	Kd	=	223.87	6.65	-	2	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	762.4	12	8	8	1.44	CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	https://dx.doi.org/10.1021/jm00047a020
CHEMBL131872	21730	None	12	Rat	Functional	EC50	=	3.70	8.43	316	3	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	920.5	29	11	13	-2.40	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O	https://dx.doi.org/10.1021/jm00100a027
CHEMBL131923	21795	None	0	Rat	Functional	EC50	=	59.00	7.23	19	3	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	946.5	28	10	13	-2.06	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O	https://dx.doi.org/10.1021/jm00100a027
CHEMBL133362	23497	None	0	Rat	Functional	EC50	=	1390.00	5.86	-4	2	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	777.4	21	5	8	2.30	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O	https://dx.doi.org/10.1021/jm00100a027
CHEMBL134012	24271	None	0	Rat	Functional	EC50	=	15.00	7.82	36	2	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763.4	21	5	8	1.77	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O	https://dx.doi.org/10.1021/jm00100a027
CHEMBL134091	24356	None	0	Rat	Functional	EC50	=	1.30	8.89	33	2	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	962.5	30	11	13	-2.22	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O	https://dx.doi.org/10.1021/jm00100a027
CHEMBL134481	211188	None	0	Rat	Functional	EC50	=	33.00	7.48	1	3	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O	https://dx.doi.org/10.1021/jm00100a027
CHEMBL135186	25649	None	0	Rat	Functional	EC50	=	62.00	7.21	1	3	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	737.4	22	6	8	1.43	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O	https://dx.doi.org/10.1021/jm00100a027
CHEMBL156128	49073	None	0	Rat	Functional	Kd	=	3.98	8.40	-	2	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	643.3	10	3	7	3.03	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O	https://dx.doi.org/10.1021/jm960213s
CHEMBL156186	49137	None	0	Rat	Functional	Kd	=	100.00	7.00	-	3	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	639.3	13	4	7	2.60	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	https://dx.doi.org/10.1021/jm960213s
CHEMBL157858	51047	None	0	Rat	Functional	Kd	=	199.53	6.70	-	3	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	653.3	13	4	7	3.16	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O	https://dx.doi.org/10.1021/jm960213s

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Ligand source activities (1 row/activity)