Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 1765 | 3817 | None | 60 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -15 | 10 | Antagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assayAntagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assay |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1021/acs.jmedchem.2c01632 | ||
| 4184 | 3817 | None | 60 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -15 | 10 | Antagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assayAntagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assay |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1021/acs.jmedchem.2c01632 | ||
| 9871419 | 3817 | None | 60 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -15 | 10 | Antagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assayAntagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assay |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1021/acs.jmedchem.2c01632 | ||
| 9871419.0 | 3817 | None | 60 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -15 | 10 | Antagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assayAntagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assay |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1021/acs.jmedchem.2c01632 | ||
| CHEMBL398435 | 3817 | None | 60 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -15 | 10 | Antagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assayAntagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assay |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1021/acs.jmedchem.2c01632 | ||
| DB08816 | 3817 | None | 60 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -15 | 10 | Antagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assayAntagonist activity at human P2Y13R expressed in HEK293 cells assessed as inhibition of 2MeSADP-induced cAMP production preincubated for 0.5 hrs followed by 2MeSADP stimulation by cAMP-glo assay |
ChEMBL | 522 | 10 | 4 | 11 | 2.0 | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO | 10.1021/acs.jmedchem.2c01632 | ||
| 1713 | 520 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 10 | NoneNone |
Drug Central | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | None | ||
| 5957 | 520 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 10 | NoneNone |
Drug Central | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | None | ||
| 91 | 520 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 10 | NoneNone |
Drug Central | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | None | ||
| CHEMBL14249 | 520 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 10 | NoneNone |
Drug Central | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | None | ||
| DB00171 | 520 | None | 42 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -8 | 10 | NoneNone |
Drug Central | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | None | ||
| 135973538 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| 1728 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| 2966 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| 4261196 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| 5361 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| 5361.0 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| CHEMBL265502 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| DB04786 | 3710 | None | 26 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 2 | 10 | NoneNone |
Drug Central | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | None | ||
| 1776 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -9 | 4 | NoneNone |
Drug Central | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | None | ||
| 5006 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -9 | 4 | NoneNone |
Drug Central | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | None | ||
| 9854012 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -9 | 4 | NoneNone |
Drug Central | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | None | ||
| 9854012.0 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -9 | 4 | NoneNone |
Drug Central | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | None | ||
| CHEMBL334966 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -9 | 4 | NoneNone |
Drug Central | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | None | ||
| DB06441 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -9 | 4 | NoneNone |
Drug Central | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | None | ||
| 1764 | 76 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 393 | 5 | 5 | 11 | -1.1 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(O)O | 12815166 | ||
| 189762 | 76 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 393 | 5 | 5 | 11 | -1.1 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(O)O | 12815166 | ||
| CHEMBL606240 | 76 | None | 0 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 393 | 5 | 5 | 11 | -1.1 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(O)O | 12815166 | ||
| 1755 | 289 | None | 12 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -794 | 6 | UnclassifiedUnclassified |
Guide to Pharmacology | 443 | 6 | 6 | 12 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| 5310996 | 289 | None | 12 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -794 | 6 | UnclassifiedUnclassified |
Guide to Pharmacology | 443 | 6 | 6 | 12 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| CHEMBL335206 | 289 | None | 12 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -794 | 6 | UnclassifiedUnclassified |
Guide to Pharmacology | 443 | 6 | 6 | 12 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| 136078744 | 2645 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 432 | 7 | 4 | 9 | 3.2 | OCc1c(COP(=O)(O)O)c(/N=N/c2cc(ccc2Cl)N(=O)=O)nc(c1O)C | 15913566 | ||
| 1777 | 2645 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 432 | 7 | 4 | 9 | 3.2 | OCc1c(COP(=O)(O)O)c(/N=N/c2cc(ccc2Cl)N(=O)=O)nc(c1O)C | 15913566 | ||
| 135545444 | 2653 | None | 10 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 430 | 7 | 3 | 8 | 1.6 | O=CC1=C(COP(=O)(O)O)/C(=N/Nc2ccc(c(c2)[N+](=O)[O-])Cl)/N=C(C1=O)C | 15913566 | ||
| 1778 | 2653 | None | 10 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 430 | 7 | 3 | 8 | 1.6 | O=CC1=C(COP(=O)(O)O)/C(=N/Nc2ccc(c(c2)[N+](=O)[O-])Cl)/N=C(C1=O)C | 15913566 | ||
| CHEMBL5281019 | 2653 | None | 10 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 430 | 7 | 3 | 8 | 1.6 | O=CC1=C(COP(=O)(O)O)/C(=N/Nc2ccc(c(c2)[N+](=O)[O-])Cl)/N=C(C1=O)C | 15913566 | ||
| 1712 | 288 | None | 48 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -7 | 6 | UnclassifiedUnclassified |
Guide to Pharmacology | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| 6022 | 288 | None | 48 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -7 | 6 | UnclassifiedUnclassified |
Guide to Pharmacology | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| CHEMBL14830 | 288 | None | 48 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -7 | 6 | UnclassifiedUnclassified |
Guide to Pharmacology | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| 1732 | 450 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 3 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 832 | 14 | 6 | 29 | -5.0 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2cnc3c2ncnc3N)[O-])[O-])[O-])[O-])O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| 25243905 | 450 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 3 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 832 | 14 | 6 | 29 | -5.0 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2cnc3c2ncnc3N)[O-])[O-])[O-])[O-])O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 12815166 | ||
| 1711 | 77 | None | 13 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -18 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 12815166 | ||
| 5310983 | 77 | None | 13 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -18 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 12815166 | ||
| CHEMBL336208 | 77 | None | 13 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -18 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 12815166 | ||
| 1776 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -9 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 12815166 | ||
| 5006 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -9 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 12815166 | ||
| 9854012 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -9 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 12815166 | ||
| 9854012.0 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -9 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 12815166 | ||
| CHEMBL334966 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -9 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 12815166 | ||
| DB06441 | 787 | None | 27 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -9 | 4 | UnclassifiedUnclassified |
Guide to Pharmacology | 775 | 15 | 7 | 15 | 2.9 | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 12815166 | ||
Showing 1 to 50 of 77 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 135405867 | 84439 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Antagonist activity at human P2Y13Antagonist activity at human P2Y13 |
ChEMBL | 430 | 7 | 3 | 9 | 3.5 | Cc1nc(/N=N/c2cc([N+](=O)[O-])ccc2Cl)c(COP(=O)(O)O)c(C=O)c1O | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL2219665 | 84439 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Antagonist activity at human P2Y13Antagonist activity at human P2Y13 |
ChEMBL | 430 | 7 | 3 | 9 | 3.5 | Cc1nc(/N=N/c2cc([N+](=O)[O-])ccc2Cl)c(COP(=O)(O)O)c(C=O)c1O | 10.1021/acs.jmedchem.5b01972 | ||
| 1725 | 3153 | None | 14 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 511 | 8 | 5 | 11 | 1.4 | O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C | 10.1021/acs.jmedchem.5b01972 | ||
| 4881 | 3153 | None | 14 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 511 | 8 | 5 | 11 | 1.4 | O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL1437958 | 3153 | None | 14 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 511 | 8 | 5 | 11 | 1.4 | O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL69234 | 3153 | None | 14 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 511 | 8 | 5 | 11 | 1.4 | O=Cc1c(COP(=O)(O)O)c(/N=N/c2ccc(cc2S(=O)(=O)O)S(=O)(=O)O)nc(c1O)C | 10.1021/acs.jmedchem.5b01972 | ||
| 136677322 | 3296 | None | 17 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 773 | 9 | 7 | 15 | 3.9 | OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1 | 10.1021/acs.jmedchem.5b01972 | ||
| 1739 | 3296 | None | 17 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 773 | 9 | 7 | 15 | 3.9 | OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1 | 10.1021/acs.jmedchem.5b01972 | ||
| 656725 | 3296 | None | 17 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 773 | 9 | 7 | 15 | 3.9 | OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1 | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL1160031 | 3296 | None | 17 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 773 | 9 | 7 | 15 | 3.9 | OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1 | 10.1021/acs.jmedchem.5b01972 | ||
| 135973538 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| 1728 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| 2966 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| 4261196 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| 5361 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| 5361.0 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL265502 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| DB04786 | 3710 | None | 26 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 2 | Antagonist activity at P2Y13 (unknown origin)Antagonist activity at P2Y13 (unknown origin) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/acs.jmedchem.5b01972 | ||
| 135545444 | 2653 | None | 10 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | Antagonist activity at human P2Y13Antagonist activity at human P2Y13 |
ChEMBL | 430 | 7 | 3 | 8 | 1.6 | O=CC1=C(COP(=O)(O)O)/C(=N/Nc2ccc(c(c2)[N+](=O)[O-])Cl)/N=C(C1=O)C | 10.1021/acs.jmedchem.5b01972 | ||
| 1778 | 2653 | None | 10 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | Antagonist activity at human P2Y13Antagonist activity at human P2Y13 |
ChEMBL | 430 | 7 | 3 | 8 | 1.6 | O=CC1=C(COP(=O)(O)O)/C(=N/Nc2ccc(c(c2)[N+](=O)[O-])Cl)/N=C(C1=O)C | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL5281019 | 2653 | None | 10 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | Antagonist activity at human P2Y13Antagonist activity at human P2Y13 |
ChEMBL | 430 | 7 | 3 | 8 | 1.6 | O=CC1=C(COP(=O)(O)O)/C(=N/Nc2ccc(c(c2)[N+](=O)[O-])Cl)/N=C(C1=O)C | 10.1021/acs.jmedchem.5b01972 | ||
Showing 1 to 21 of 21 entries