GPCRdb

suramin

Agent/drug
Bioactivity

suramin

No image available

SMILES	Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C)c2)c1
InChIKey	FIAFUQMPZJWCLV-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	17
Hydrogen bond donors	12
Rotatable bonds	16
Molecular weight (Da)	1296.0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem PubChem GPCRdb
Ligand site mutations	P2Y₁₂

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

P2Y₁	P2RY1	Human	P2Y	A	pKi	8.28	8.28	8.28	Drug Central
P2Y₁	P2RY1	Human	P2Y	A	pKi	5.30	5.30	5.30	Guide to Pharmacology
P2Y₁₁	P2Y11	Human	P2Y	A	pKi	6.52	6.73	6.95	ChEMBL

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.80	5.80	5.80	ChEMBL
P2Y₁₁	P2Y11	Human	P2Y	A	pIC50	4.80	5.40	6.00	Guide to Pharmacology
P2Y₁₁	P2Y11	Human	P2Y	A	pEC50	4.80	4.80	4.80	ChEMBL
P2Y₁₁	P2Y11	Human	P2Y	A	pIC50	8.22	8.22	8.22	Drug Central
P2Y₁₂	P2Y12	Rat	P2Y	A	pEC50	5.40	5.40	5.40	ChEMBL
P2Y₁₃	P2Y13	Human	P2Y	A	pIC50	5.60	5.60	5.60	Guide to Pharmacology
P2Y₁₃	P2Y13	Human	P2Y	A	pIC50	5.64	5.64	5.64	ChEMBL
P2Y₁₃	P2Y13	Human	P2Y	A	pIC50	8.25	8.25	8.25	Drug Central
P2Y₂	P2RY2	Human	P2Y	A	pIC50	4.30	4.30	4.30	Guide to Pharmacology
P2Y₂	P2RY2	Human	P2Y	A	pEC50	4.32	4.32	4.32	ChEMBL
P2Y₂	P2RY2	Human	P2Y	A	pIC50	4.30	4.30	4.30	ChEMBL
P2Y₂	P2RY2	Human	P2Y	A	pIC50	8.37	8.37	8.37	Drug Central
P2Y₆	P2RY6	Human	P2Y	A	pKB	4.00	4.00	4.00	Guide to Pharmacology
P2Y₆	P2RY6	Human	P2Y	A	pIC50	4.57	4.57	4.57	ChEMBL
P2Y₆	P2RY6	Human	P2Y	A	pKb	8.40	8.40	8.40	Drug Central
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.20	5.20	5.20	ChEMBL

Showing 1 to 16 of 16 entries

suramin

No image available

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 4

Phase II 16

Phase III 2

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem PubChem PubChem GPCRdb
Ligand site mutations	P2Y₁₂

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

FSHR	FSH receptor	Glycoprotein hormone receptors	Protein receptors	Class A	Adenocarcinoma of prostate	2C82.0	P01C	0.100	2	Yes
FSHR	FSH receptor	Glycoprotein hormone receptors	Protein receptors	Class A	Malignant neoplasms of adrenal gland, unspecified	2D11.Z	P01C	0.002	2	Yes
FSHR	FSH receptor	Glycoprotein hormone receptors	Protein receptors	Class A	Malignant neoplasms of breast, unspecified	2C6Z	P01C	0.068	2	Yes
FSHR	FSH receptor	Glycoprotein hormone receptors	Protein receptors	Class A	Renal cell carcinoma of kidney, except renal pelvis	2C90.0	P01C	0.007	2	Yes
P2RY2	P2Y₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Leishmaniasis, unspecified	1F54.Z	P01C	0.009	4	Yes
P2RY2	P2Y₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Malignant neoplasms of breast, unspecified	2C6Z	P01C	0.041	2	Yes
P2RY2	P2Y₂ receptor	P2Y receptors	Nucleotide receptors	Class A	Malignant neoplasms of rectosigmoid junction, unspecified	2B91.Z	P01C	0.008	1	Yes

Showing 1 to 7 of 7 entries