Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 16200912 | 191654 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 3541 | 107 | 52 | 45 | -8.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)[C@@H](C)O)C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5194519 | 191654 | None | 2 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 3541 | 107 | 52 | 45 | -8.6 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)[C@@H](C)O)C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | 10.1016/j.ejmech.2022.114149 | ||
| 168271765 | 190589 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1501 | 52 | 21 | 18 | -2.0 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5178929 | 190589 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1501 | 52 | 21 | 18 | -2.0 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168285705 | 191428 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1526 | 51 | 20 | 17 | -0.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5191389 | 191428 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1526 | 51 | 20 | 17 | -0.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCNC(=O)C(F)(F)F)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168270674 | 190155 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 2346 | 71 | 35 | 33 | -10.7 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5172042 | 190155 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 2346 | 71 | 35 | 33 | -10.7 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168297636 | 192431 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1687 | 59 | 24 | 21 | -3.4 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5206425 | 192431 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1687 | 59 | 24 | 21 | -3.4 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168277404 | 190511 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1444 | 51 | 20 | 17 | -1.1 | CC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5177662 | 190511 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1444 | 51 | 20 | 17 | -1.1 | CC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168287513 | 191644 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Partial agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayPartial agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1317 | 46 | 19 | 16 | -2.1 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5194363 | 191644 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Partial agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayPartial agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1317 | 46 | 19 | 16 | -2.1 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168271855 | 190669 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5180015 | 190669 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168283513 | 191171 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1601 | 54 | 21 | 17 | 0.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5187335 | 191171 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1601 | 54 | 21 | 17 | 0.8 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168279710 | 191250 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1444 | 50 | 20 | 17 | -1.1 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5188323 | 191250 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1444 | 50 | 20 | 17 | -1.1 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168271345 | 190657 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 51 | 20 | 17 | -1.4 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5179908 | 190657 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 51 | 20 | 17 | -1.4 | CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168289116 | 191437 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1517 | 53 | 22 | 19 | -3.0 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5191528 | 191437 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1517 | 53 | 22 | 19 | -3.0 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168283669 | 191352 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1503 | 53 | 22 | 19 | -3.4 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5190117 | 191352 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1503 | 53 | 22 | 19 | -3.4 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168293769 | 192279 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5204006 | 192279 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168287242 | 191854 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1444 | 51 | 20 | 17 | -1.1 | CC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5197385 | 191854 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1444 | 51 | 20 | 17 | -1.1 | CC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168268972 | 190067 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 2581 | 79 | 37 | 34 | -7.3 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)[C@@H](C)O)C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5170622 | 190067 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 2581 | 79 | 37 | 34 | -7.3 | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)[C@@H](C)O)C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168273823 | 190680 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5180153 | 190680 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168296332 | 192548 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5208352 | 192548 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168277524 | 190828 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1373 | 48 | 19 | 16 | -0.6 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5182424 | 190828 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1373 | 48 | 19 | 16 | -0.6 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168285614 | 191864 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1434 | 48 | 22 | 19 | -5.2 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5197610 | 191864 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1434 | 48 | 22 | 19 | -5.2 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168283818 | 191037 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1368 | 47 | 20 | 17 | -3.1 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)(C)C | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5185495 | 191037 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1368 | 47 | 20 | 17 | -3.1 | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)(C)C | 10.1016/j.ejmech.2022.114149 | ||
| 168277682 | 190299 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1503 | 53 | 22 | 19 | -3.4 | CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5174290 | 190299 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1503 | 53 | 22 | 19 | -3.4 | CC(C)C[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168293769 | 192279 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5204006 | 192279 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1430 | 50 | 20 | 17 | -1.5 | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168287242 | 191854 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1444 | 51 | 20 | 17 | -1.1 | CC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5197385 | 191854 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assayAgonist activity at human NPBWR1 expressed in CHO cells measured by LANCE Ultra cAMP kit-based TR-FRET assay |
ChEMBL | 1444 | 51 | 20 | 17 | -1.1 | CC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| 168287324 | 191908 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1373 | 48 | 19 | 16 | -0.6 | CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
| CHEMBL5198287 | 191908 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | Agonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assayAgonist activity at human NPBWR1 expressed in CHO-RD-HGA16 cells measured by calcium mobilization assay |
ChEMBL | 1373 | 48 | 19 | 16 | -0.6 | CC(C)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCNC(=O)CCCCNC(=O)CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(N)=O | 10.1016/j.ejmech.2022.114149 | ||
Showing 1 to 50 of 661 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 57402913 | 69877 | None | 0 | Mouse | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 588 | 7 | 1 | 7 | 6.3 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccc(F)cc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1938418 | 69877 | None | 0 | Mouse | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 588 | 7 | 1 | 7 | 6.3 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccc(F)cc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 56951323 | 70219 | None | 0 | Mouse | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 588 | 7 | 1 | 7 | 6.3 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6cc(F)ccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940544 | 70219 | None | 0 | Mouse | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 588 | 7 | 1 | 7 | 6.3 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6cc(F)ccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 57396582 | 70215 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 586 | 7 | 1 | 7 | 6.6 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6s5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940540 | 70215 | None | 0 | Mouse | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 586 | 7 | 1 | 7 | 6.6 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6s5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 56951322 | 70220 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 587 | 7 | 2 | 6 | 6.0 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6cc(F)ccc6[nH]5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940545 | 70220 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 587 | 7 | 2 | 6 | 6.0 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6cc(F)ccc6[nH]5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 57396584 | 70218 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 584 | 7 | 1 | 7 | 6.5 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6cc(C)ccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940543 | 70218 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 584 | 7 | 1 | 7 | 6.5 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6cc(C)ccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 57393089 | 70212 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 570 | 7 | 1 | 7 | 6.2 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940537 | 70212 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 570 | 7 | 1 | 7 | 6.2 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 57393090 | 70214 | None | 0 | Mouse | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 569 | 7 | 2 | 6 | 5.9 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6[nH]5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940539 | 70214 | None | 0 | Mouse | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 569 | 7 | 2 | 6 | 5.9 | COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccccc6[nH]5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 57400020 | 70211 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 558 | 7 | 1 | 7 | 6.0 | COc1ccc(C(C)(C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nc5ccccc5o4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940536 | 70211 | None | 0 | Mouse | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 558 | 7 | 1 | 7 | 6.0 | COc1ccc(C(C)(C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nc5ccccc5o4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 50904434 | 86456 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 406 | 6 | 0 | 5 | 5.3 | CCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314291 | 86456 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 406 | 6 | 0 | 5 | 5.3 | CCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 57401831 | 70207 | None | 0 | Mouse | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 567 | 7 | 1 | 7 | 5.8 | CC(C)(N[C@@H]1CC[C@H](C(=O)N2CCN(c3ccc(Cl)cn3)CC2)[C@@H](c2ccsc2)C1)c1ccc([N+](=O)[O-])cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940532 | 70207 | None | 0 | Mouse | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 567 | 7 | 1 | 7 | 5.8 | CC(C)(N[C@@H]1CC[C@H](C(=O)N2CCN(c3ccc(Cl)cn3)CC2)[C@@H](c2ccsc2)C1)c1ccc([N+](=O)[O-])cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 50904510 | 86474 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 410 | 5 | 0 | 5 | 4.8 | COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C(F)(F)F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314310 | 86474 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 410 | 5 | 0 | 5 | 4.8 | COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C(F)(F)F)cc3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 50904448 | 86479 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 384 | 6 | 0 | 5 | 4.9 | COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C(C)C)cc3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314315 | 86479 | None | 0 | Human | Binding | pIC50 | = | 5 | 5.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 384 | 6 | 0 | 5 | 4.9 | COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C(C)C)cc3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 57400010 | 70175 | None | 0 | Mouse | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 552 | 7 | 1 | 6 | 5.9 | COc1ccc(C(C)(C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(Cl)cn4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940372 | 70175 | None | 0 | Mouse | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 552 | 7 | 1 | 6 | 5.9 | COc1ccc(C(C)(C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(Cl)cn4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 51000467 | 86457 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 420 | 7 | 0 | 5 | 5.7 | CCCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314292 | 86457 | None | 0 | Human | Binding | pIC50 | = | 6.0 | 6.0 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 420 | 7 | 0 | 5 | 5.7 | CCCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 57391211 | 70165 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 534 | 8 | 1 | 7 | 5.1 | COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(OC)cn4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940362 | 70165 | None | 0 | Mouse | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 534 | 8 | 1 | 7 | 5.1 | COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(OC)cn4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 50904419 | 86494 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 464 | 7 | 0 | 7 | 5.0 | COc1ccc(Oc2c(Cl)cnn(C(COC(C)=O)c3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314330 | 86494 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 464 | 7 | 0 | 7 | 5.0 | COc1ccc(Oc2c(Cl)cnn(C(COC(C)=O)c3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 57400019 | 70206 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 564 | 7 | 1 | 6 | 6.1 | COc1cccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5ccc(Cl)cn5)CC4)[C@@H](c4ccsc4)C3)CCC2)c1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940531 | 70206 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 564 | 7 | 1 | 6 | 6.1 | COc1cccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5ccc(Cl)cn5)CC4)[C@@H](c4ccsc4)C3)CCC2)c1 | 10.1016/j.bmcl.2011.11.126 | ||
| 50904505 | 71961 | None | 32 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 416 | 4 | 0 | 5 | 5.3 | COc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc43)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL1972527 | 71961 | None | 32 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 416 | 4 | 0 | 5 | 5.3 | COc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc43)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 53356616 | 72120 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 400 | 6 | 0 | 7 | 3.5 | COC(=O)c1ccccc1Cn1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL1977658 | 72120 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 400 | 6 | 0 | 7 | 3.5 | COC(=O)c1ccccc1Cn1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O | 10.1016/j.bmcl.2012.12.030 | ||
| 57401830 | 70202 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 586 | 6 | 1 | 5 | 6.5 | C[C@@H](N[C@@H]1CC[C@H](C(=O)N2CCN(c3ccc(Cl)cn3)CC2)[C@@H](c2ccsc2)C1)c1ccc(Br)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940527 | 70202 | None | 0 | Mouse | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 586 | 6 | 1 | 5 | 6.5 | C[C@@H](N[C@@H]1CC[C@H](C(=O)N2CCN(c3ccc(Cl)cn3)CC2)[C@@H](c2ccsc2)C1)c1ccc(Br)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 57401815 | 70167 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 510 | 7 | 1 | 7 | 5.2 | COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nccs4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| CHEMBL1940364 | 70167 | None | 0 | Mouse | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assayDisplacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay |
ChEMBL | 510 | 7 | 1 | 7 | 5.2 | COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nccs4)CC3)[C@@H](c3ccsc3)C2)cc1 | 10.1016/j.bmcl.2011.11.126 | ||
| 50904454 | 86484 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 392 | 5 | 0 | 5 | 4.9 | COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314320 | 86484 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 392 | 5 | 0 | 5 | 4.9 | COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 53245513 | 72393 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 367 | 5 | 0 | 6 | 3.6 | COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3C#N)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL1985845 | 72393 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 367 | 5 | 0 | 6 | 3.6 | COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3C#N)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 50904443 | 86470 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 356 | 5 | 0 | 5 | 4.1 | COc1ccc(Oc2c(Cl)cnn(Cc3cccc(C)c3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314307 | 86470 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 356 | 5 | 0 | 5 | 4.1 | COc1ccc(Oc2c(Cl)cnn(Cc3cccc(C)c3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| 50904420 | 86483 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 392 | 5 | 0 | 5 | 4.9 | COc1ccc(Oc2c(Cl)cnn(Cc3ccc4ccccc4c3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
| CHEMBL2314319 | 86483 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 0 | Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assayAntagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay |
ChEMBL | 392 | 5 | 0 | 5 | 4.9 | COc1ccc(Oc2c(Cl)cnn(Cc3ccc4ccccc4c3)c2=O)cc1 | 10.1016/j.bmcl.2012.12.030 | ||
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