GPCRdb

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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ava3	525	None	0	Human	Binding	pKi	=	-	9.40	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/17486669
Ava5	526	None	0	Human	Binding	pKi	=	-	8.90	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/17486669
CHEMBL1729021	59876	None	0	Human	Binding	IC50	=	270.00	6.57	-	2	Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay	ChEMBL	356.1	4	0	5	4.30	COc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.12.030
CHEMBL1736481	60069	None	0	Human	Binding	IC50	=	1700.00	5.77	-	2	Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay	ChEMBL	356.1	5	0	5	4.05	COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C)cc3)c2=O)cc1	https://dx.doi.org/10.1016/j.bmcl.2012.12.030
CHEMBL1938418	69877	None	0	Mouse	Binding	IC50	=	0.18	9.74	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	588.3	7	1	7	6.31	COc1ccc(C2(N[C@@H]3CC[C@H](C(=O)N4CCN(c5nc6ccc(F)cc6o5)CC4)[C@@H](c4ccsc4)C3)CCC2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940354	70157	None	0	Human	Binding	IC50	=	324.00	6.49	-	2	Displacement of [125]-hNPW23 from human NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	538.2	7	1	6	5.76	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(Cl)cn4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940354	70157	None	0	Mouse	Binding	IC50	=	25.00	7.60	-	2	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	538.2	7	1	6	5.76	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(Cl)cn4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940355	70158	None	0	Mouse	Binding	IC50	=	3715.00	5.43	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	537.2	7	1	5	6.36	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(Cl)cc4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940359	70161	None	0	Mouse	Binding	IC50	=	74.00	7.13	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	538.2	7	1	6	5.76	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4cccc(Cl)n4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940360	70163	None	0	Mouse	Binding	IC50	=	18.00	7.75	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	518.3	7	1	6	5.41	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(C)cn4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940362	70165	None	0	Mouse	Binding	IC50	=	1140.00	5.94	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	534.3	8	1	7	5.11	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(OC)cn4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940363	70166	None	0	Mouse	Binding	IC50	=	194.00	6.71	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	529.3	7	1	7	4.97	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(C#N)cn4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940364	70167	None	0	Mouse	Binding	IC50	=	14.00	7.85	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	510.2	7	1	7	5.17	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nccs4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940365	70168	None	0	Mouse	Binding	IC50	=	42.00	7.38	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	588.1	7	1	7	5.93	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4ncc(Br)s4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940366	70169	None	0	Mouse	Binding	IC50	=	4.50	8.35	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	579.2	7	1	8	5.58	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nnc(C(F)(F)F)s4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940367	70170	None	0	Mouse	Binding	IC50	=	2.80	8.55	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	560.2	7	1	7	6.32	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nc5ccccc5s4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940368	70171	None	0	Mouse	Binding	IC50	=	8.30	8.08	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	544.3	7	1	7	5.85	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nc5ccccc5o4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940369	70172	None	0	Mouse	Binding	IC50	=	4.50	8.35	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	543.3	7	2	6	5.58	COc1ccc([C@@H](C)N[C@@H]2CC[C@H](C(=O)N3CCN(c4nc5ccccc5[nH]4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940370	70173	None	0	Mouse	Binding	IC50	=	1525.00	5.82	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	524.2	7	1	6	5.20	COc1ccc(CN[C@@H]2CC[C@H](C(=O)N3CCN(c4ccc(Cl)cn4)CC3)[C@@H](c3ccsc3)C2)cc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126
CHEMBL1940371	70174	None	0	Mouse	Binding	IC50	=	217.00	6.66	-	1	Displacement of [125]-hNPW23 from mouse NPBWR1 expressed in CHO-K1 cells membrane by scintillation proximity assay	ChEMBL	508.2	6	1	5	5.75	C[C@@H](N[C@@H]1CC[C@H](C(=O)N2CCN(c3ccc(Cl)cn3)CC2)[C@@H](c2ccsc2)C1)c1ccccc1	https://dx.doi.org/10.1016/j.bmcl.2011.11.126

Showing 1 to 20 of 118 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)