GPCRdb

Ligand source activities (1 row/activity)

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1012	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	1013	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	1057	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	5757	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	CHEMBL135	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	DB00783	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	1012	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	1013	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	1057	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	5757	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	CHEMBL135	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	DB00783	26	81	None	22387	3	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	1014	1676	21	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/acsmedchemlett.8b00212
	5322399	1676	21	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/acsmedchemlett.8b00212
	CHEMBL569766	1676	21	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/acsmedchemlett.8b00212
	71937602	163824	2	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	403	4	2	3	5.4	O=C(Nc1ncc(Cc2ccc(F)cc2F)s1)c1[nH]c2ccccc2c1Cl	10.1021/acsmedchemlett.8b00212
	CHEMBL4212956	163824	2	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	403	4	2	3	5.4	O=C(Nc1ncc(Cc2ccc(F)cc2F)s1)c1[nH]c2ccccc2c1Cl	10.1021/acsmedchemlett.8b00212
	1014	1676	21	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio775
	5322399	1676	21	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio775
	CHEMBL569766	1676	21	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio775
	1014	1676	21	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm400132d
	5322399	1676	21	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm400132d
	CHEMBL569766	1676	21	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm400132d
	25481402	163098	5	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	369	4	2	3	4.7	O=C(Nc1ncc(Cc2ccc(F)cc2)s1)c1cc2cc(F)ccc2[nH]1	10.1021/acsmedchemlett.8b00212
	CHEMBL4204236	163098	5	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	369	4	2	3	4.7	O=C(Nc1ncc(Cc2ccc(F)cc2)s1)c1cc2cc(F)ccc2[nH]1	10.1021/acsmedchemlett.8b00212
	135351819	163123	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	397	3	2	3	5.2	CCc1nc(NC(=O)c2[nH]c3ccc(Br)cc3c2Cl)sc1C	10.1021/acsmedchemlett.8b00212
	CHEMBL4204670	163123	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay	ChEMBL	397	3	2	3	5.2	CCc1nc(NC(=O)c2[nH]c3ccc(Br)cc3c2Cl)sc1C	10.1021/acsmedchemlett.8b00212
	3320	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilization	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	7433743	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilization	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	CHEMBL583543	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilization	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	3320	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilization	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	7433743	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilization	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	CHEMBL583543	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilization	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	60203890	189372	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Agonist activity at GPER (unknown origin)Agonist activity at GPER (unknown origin)	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1C(c1cc3c(cc1Br)OCO3)N2	10.1016/j.ejmech.2022.114658
	CHEMBL5170710	189372	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Agonist activity at GPER (unknown origin)Agonist activity at GPER (unknown origin)	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1C(c1cc3c(cc1Br)OCO3)N2	10.1016/j.ejmech.2022.114658
	2351	3234	60	None	16	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	2820	3234	60	None	16	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	5035	3234	60	None	16	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	CHEMBL81	3234	60	None	16	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	DB00481	3234	60	None	16	22	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	1015	1670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	None
	104741	1670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	None
	1255	1670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	None
	CHEMBL1358	1670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	None
	DB00947	1670	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	None
	1012	26	81	None	22387	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	None
	1013	26	81	None	22387	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	None
	1057	26	81	None	22387	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	None
	5757	26	81	None	22387	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	None
	CHEMBL135	26	81	None	22387	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	None
	DB00783	26	81	None	22387	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	None
	1016	3690	75	None	31	35	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3690	75	None	31	35	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3690	75	None	31	35	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3690	75	None	31	35	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3690	75	None	31	35	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3690	75	None	31	35	Human	8.1	pIC50	=	8.1	Functional	NoneNone	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	3320	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	19430488
	7433743	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	19430488
	CHEMBL583543	1677	28	None	-	1	Human	6.7	pIC50	=	6.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	19430488
	6480	1678	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	411	2	1	3	6.1	CC(c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br)C	21782022
	73755224	1678	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	411	2	1	3	6.1	CC(c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br)C	21782022

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1014	1676	21	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GPR30Binding affinity to GPR30	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm9011802
	5322399	1676	21	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GPR30Binding affinity to GPR30	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm9011802
	CHEMBL569766	1676	21	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GPR30Binding affinity to GPR30	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm9011802
	3320	1677	28	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Binding affinity to GPR30Binding affinity to GPR30	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1021/jm9011802
	7433743	1677	28	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Binding affinity to GPR30Binding affinity to GPR30	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1021/jm9011802
	CHEMBL583543	1677	28	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Binding affinity to GPR30Binding affinity to GPR30	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1021/jm9011802
	1014	1676	21	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio775
	5322399	1676	21	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio775
	CHEMBL569766	1676	21	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio775
	1014	1676	21	None	-	1	Human	8.0	pKi	=	8.0	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm400132d
	5322399	1676	21	None	-	1	Human	8.0	pKi	=	8.0	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm400132d
	CHEMBL569766	1676	21	None	-	1	Human	8.0	pKi	=	8.0	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1021/jm400132d
	1012	26	81	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1039/C5MD00455A
	1013	26	81	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1039/C5MD00455A
	1057	26	81	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1039/C5MD00455A
	5757	26	81	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1039/C5MD00455A
	CHEMBL135	26	81	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1039/C5MD00455A
	DB00783	26	81	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1039/C5MD00455A
	3320	1677	28	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	7433743	1677	28	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	CHEMBL583543	1677	28	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay	ChEMBL	369	1	1	3	5.0	Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2	10.1038/nchembio.168
	1012	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	1013	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	1057	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	5757	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	CHEMBL135	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	DB00783	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/nchembio775
	1012	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	1013	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	1057	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	5757	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	CHEMBL135	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	DB00783	26	81	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1021/jm400132d
	1014	1676	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio.168
	5322399	1676	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio.168
	CHEMBL569766	1676	21	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay	ChEMBL	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	10.1038/nchembio.168
	12058	79	0	None	-	1	Human	8.0	pKd	=	8	Binding	Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>	Guide to Pharmacology	302	1	2	3	3.6	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O	24262995
	66414	79	0	None	-	1	Human	8.0	pKd	=	8	Binding	Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>	Guide to Pharmacology	302	1	2	3	3.6	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O	24262995
	CHEMBL299613	79	0	None	-	1	Human	8.0	pKd	=	8	Binding	Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>	Guide to Pharmacology	302	1	2	3	3.6	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O	24262995
	DB02342	79	0	None	-	1	Human	8.0	pKd	=	8	Binding	Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>	Guide to Pharmacology	302	1	2	3	3.6	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O	24262995
	1012	26	81	None	-	1	Human	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	1013	26	81	None	-	1	Human	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	1057	26	81	None	-	1	Human	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	5757	26	81	None	-	1	Human	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	CHEMBL135	26	81	None	-	1	Human	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	DB00783	26	81	None	-	1	Human	8.6	pKd	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	1015	1670	0	None	-	1	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	15539556
	104741	1670	0	None	-	1	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	15539556
	1255	1670	0	None	-	1	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	15539556
	CHEMBL1358	1670	0	None	-	1	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	15539556
	DB00947	1670	0	None	-	1	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	606	14	2	3	8.7	O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O	15539556
	2351	3234	60	None	-15	21	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	24379833
	2820	3234	60	None	-15	21	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	24379833
	5035	3234	60	None	-15	21	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	24379833
	CHEMBL81	3234	60	None	-15	21	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	24379833
	DB00481	3234	60	None	-15	21	Human	7.0	pKi	=	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	24379833
	1014	1676	21	None	-	1	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	16520733
	5322399	1676	21	None	-	1	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	16520733
	CHEMBL569766	1676	21	None	-	1	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	411	2	1	4	5.2	CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br	16520733
	1012	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	1012	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15705806
	1013	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	1013	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15705806
	1057	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	1057	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15705806
	5757	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	5757	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15705806
	CHEMBL135	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	CHEMBL135	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15705806
	DB00783	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15539556
	DB00783	26	81	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	15705806
	1016	3690	75	None	-194	35	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	15539556
	2561	3690	75	None	-194	35	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	15539556
	2733526	3690	75	None	-194	35	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	15539556
	5384	3690	75	None	-194	35	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	15539556
	CHEMBL83	3690	75	None	-194	35	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	15539556
	DB00675	3690	75	None	-194	35	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	15539556

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Ligand source activities (1 row/activity)