Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
1012 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
1013 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
1057 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
5757 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
CHEMBL135 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
DB00783 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
1012 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
1013 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
1057 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
5757 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
CHEMBL135 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
DB00783 6814 86 None 7079 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
1014 8487 27 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/acsmedchemlett.8b00212
5322399 8487 27 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/acsmedchemlett.8b00212
CHEMBL569766 8487 27 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/acsmedchemlett.8b00212
71937602 171155 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 403 4 2 3 5.4 O=C(Nc1ncc(Cc2ccc(F)cc2F)s1)c1[nH]c2ccccc2c1Cl 10.1021/acsmedchemlett.8b00212
CHEMBL4212956 171155 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 403 4 2 3 5.4 O=C(Nc1ncc(Cc2ccc(F)cc2F)s1)c1[nH]c2ccccc2c1Cl 10.1021/acsmedchemlett.8b00212
1014 8487 27 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio775
5322399 8487 27 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio775
CHEMBL569766 8487 27 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetryAgonist activity at GFP-tagged GPR30 expressed in COS7 cells assessed as half life for increase in intracellular calcium level by spectrofluorimetry
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio775
1014 8487 27 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm400132d
5322399 8487 27 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm400132d
CHEMBL569766 8487 27 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at GPR30 (unknown origin) by calcium mobilization assayAgonist activity at GPR30 (unknown origin) by calcium mobilization assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm400132d
25481402 170429 4 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 369 4 2 3 4.7 O=C(Nc1ncc(Cc2ccc(F)cc2)s1)c1cc2cc(F)ccc2[nH]1 10.1021/acsmedchemlett.8b00212
CHEMBL4204236 170429 4 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 369 4 2 3 4.7 O=C(Nc1ncc(Cc2ccc(F)cc2)s1)c1cc2cc(F)ccc2[nH]1 10.1021/acsmedchemlett.8b00212
135351819 170454 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 397 3 2 3 5.2 CCc1nc(NC(=O)c2[nH]c3ccc(Br)cc3c2Cl)sc1C 10.1021/acsmedchemlett.8b00212
CHEMBL4204670 170454 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assayAgonist activity at GPER (unknown origin) expressed in human HL60 cells assessed as increase in cAMP accumulation in presence of IBMX after 15 mins by HTRF assay
ChEMBL 397 3 2 3 5.2 CCc1nc(NC(=O)c2[nH]c3ccc(Br)cc3c2Cl)sc1C 10.1021/acsmedchemlett.8b00212
3320 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilization
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
7433743 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilization
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
CHEMBL583543 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of G1-mediated calcium mobilization
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
3320 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilization
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
7433743 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilization
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
CHEMBL583543 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilizationAntagonist activity at GPR30 in human SKBr3 cells assessed as inhibition of E2-mediated calcium mobilization
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
60203890 196744 0 None - 0 Human 8.0 pKi = 8.0 Functional
Agonist activity at GPER (unknown origin)Agonist activity at GPER (unknown origin)
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1C(c1cc3c(cc1Br)OCO3)N2 10.1016/j.ejmech.2022.114658
CHEMBL5170710 196744 0 None - 0 Human 8.0 pKi = 8.0 Functional
Agonist activity at GPER (unknown origin)Agonist activity at GPER (unknown origin)
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1C(c1cc3c(cc1Br)OCO3)N2 10.1016/j.ejmech.2022.114658
2351 10059 64 None 16 27 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
2820 10059 64 None 16 27 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
5035 10059 64 None 16 27 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
CHEMBL81 10059 64 None 16 27 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
DB00481 10059 64 None 16 27 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O None
1015 8481 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O None
104741 8481 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O None
1255 8481 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O None
CHEMBL1358 8481 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O None
DB00947 8481 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O None
1012 6814 86 None 7079 4 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C None
1013 6814 86 None 7079 4 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C None
1057 6814 86 None 7079 4 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C None
5757 6814 86 None 7079 4 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C None
CHEMBL135 6814 86 None 7079 4 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C None
DB00783 6814 86 None 7079 4 Human 8.0 pEC50 = 8.0 Functional
NoneNone
Drug Central 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C None
1016 10519 78 None 31 40 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2561 10519 78 None 31 40 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
2733526 10519 78 None 31 40 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
5384 10519 78 None 31 40 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
CHEMBL83 10519 78 None 31 40 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
DB00675 10519 78 None 31 40 Human 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 None
3320 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 19430488
7433743 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 19430488
CHEMBL583543 8488 36 None - 1 Human 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 19430488
6480 8489 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 411 2 1 3 6.1 CC(c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br)C 21782022
73755224 8489 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 411 2 1 3 6.1 CC(c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br)C 21782022


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
1014 8487 27 None - 1 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to GPR30Binding affinity to GPR30
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm9011802
5322399 8487 27 None - 1 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to GPR30Binding affinity to GPR30
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm9011802
CHEMBL569766 8487 27 None - 1 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to GPR30Binding affinity to GPR30
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm9011802
3320 8488 36 None - 1 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to GPR30Binding affinity to GPR30
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1021/jm9011802
7433743 8488 36 None - 1 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to GPR30Binding affinity to GPR30
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1021/jm9011802
CHEMBL583543 8488 36 None - 1 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to GPR30Binding affinity to GPR30
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1021/jm9011802
1014 8487 27 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio775
5322399 8487 27 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio775
CHEMBL569766 8487 27 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio775
1014 8487 27 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm400132d
5322399 8487 27 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm400132d
CHEMBL569766 8487 27 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1021/jm400132d
1012 6814 86 None - 1 Human 8.6 pKi = 8.6 Binding
Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1039/C5MD00455A
1013 6814 86 None - 1 Human 8.6 pKi = 8.6 Binding
Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1039/C5MD00455A
1057 6814 86 None - 1 Human 8.6 pKi = 8.6 Binding
Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1039/C5MD00455A
5757 6814 86 None - 1 Human 8.6 pKi = 8.6 Binding
Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1039/C5MD00455A
CHEMBL135 6814 86 None - 1 Human 8.6 pKi = 8.6 Binding
Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1039/C5MD00455A
DB00783 6814 86 None - 1 Human 8.6 pKi = 8.6 Binding
Competitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysisCompetitive binding affinity to G-protein coupled estrogen receptor (unknown origin) expressed in COS7 cells by E2 Alexa 633 staining based fluorescence analysis
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1039/C5MD00455A
3320 8488 36 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
7433743 8488 36 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
CHEMBL583543 8488 36 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay
ChEMBL 369 1 1 3 5.0 Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@H]2[C@@H]1CC=C2 10.1038/nchembio.168
1012 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
1013 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
1057 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
5757 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
CHEMBL135 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
DB00783 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACSDisplacement of E2-Alexa633 from GFP-tagged GPR30 expressed in COS7 cells by FACS
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1038/nchembio775
1012 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
1013 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
1057 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
5757 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
CHEMBL135 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
DB00783 6814 86 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition of estrogen binding to GPR30 (unknown origin)Inhibition of estrogen binding to GPR30 (unknown origin)
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm400132d
1014 8487 27 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio.168
5322399 8487 27 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio.168
CHEMBL569766 8487 27 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity to GPR30 in human Hec50 cells by competitive binding assayBinding affinity to GPR30 in human Hec50 cells by competitive binding assay
ChEMBL 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 10.1038/nchembio.168
12058 6867 0 None - 1 Human 8.0 pKd = 8 Binding
Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>
Guide to Pharmacology 302 1 2 3 3.6 C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O 24262995
66414 6867 0 None - 1 Human 8.0 pKd = 8 Binding
Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>
Guide to Pharmacology 302 1 2 3 3.6 C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O 24262995
CHEMBL299613 6867 0 None - 1 Human 8.0 pKd = 8 Binding
Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>
Guide to Pharmacology 302 1 2 3 3.6 C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O 24262995
DB02342 6867 0 None - 1 Human 8.0 pKd = 8 Binding
Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>Specific binding affinity of [<sup>3</sup>H]2ME2 to GPER <i>in vitro</i>
Guide to Pharmacology 302 1 2 3 3.6 C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCc1cc(c(cc31)OC)O 24262995
1012 6814 86 None - 1 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
1013 6814 86 None - 1 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
1057 6814 86 None - 1 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
5757 6814 86 None - 1 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
CHEMBL135 6814 86 None - 1 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
DB00783 6814 86 None - 1 Human 8.6 pKd = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
1015 8481 0 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O 15539556
104741 8481 0 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O 15539556
1255 8481 0 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O 15539556
CHEMBL1358 8481 0 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O 15539556
DB00947 8481 0 None - 1 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 606 14 2 3 8.7 O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O 15539556
2351 10059 64 None -15 21 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 24379833
2820 10059 64 None -15 21 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 24379833
5035 10059 64 None -15 21 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 24379833
CHEMBL81 10059 64 None -15 21 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 24379833
DB00481 10059 64 None -15 21 Human 7.0 pKi = 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O 24379833
1014 8487 27 None - 1 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 16520733
5322399 8487 27 None - 1 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 16520733
CHEMBL569766 8487 27 None - 1 Human 8.0 pKi = 8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 411 2 1 4 5.2 CC(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@@H](N2)c1cc2OCOc2cc1Br 16520733
1012 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
1012 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15705806
1013 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
1013 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15705806
1057 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
1057 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15705806
5757 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
5757 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15705806
CHEMBL135 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
CHEMBL135 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15705806
DB00783 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15539556
DB00783 6814 86 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 15705806
1016 10519 78 None -194 35 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 15539556
2561 10519 78 None -194 35 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 15539556
2733526 10519 78 None -194 35 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 15539556
5384 10519 78 None -194 35 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 15539556
CHEMBL83 10519 78 None -194 35 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 15539556
DB00675 10519 78 None -194 35 Human 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 15539556