Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 11648468 | 133501 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 | 10.1021/jm050418d | ||
| CHEMBL370577 | 133501 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 | 10.1021/jm050418d | ||
| 10410351 | 72380 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 428 | 7 | 0 | 2 | 6.8 | N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| CHEMBL198505 | 72380 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.9 | 4.9 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 428 | 7 | 0 | 2 | 6.8 | N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| 10811537 | 71442 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 410 | 7 | 1 | 3 | 5.3 | N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| CHEMBL195943 | 71442 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.6 | 4.6 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 410 | 7 | 1 | 3 | 5.3 | N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| 10670785 | 33128 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 440 | 8 | 1 | 4 | 5.3 | COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm050418d | ||
| CHEMBL141713 | 33128 | None | 0 | strain AD169 | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 440 | 8 | 1 | 4 | 5.3 | COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm050418d | ||
| 9889700 | 118652 | None | 11 | strain AD169 | Functional | pEC50 | = | 5.5 | 5.5 | -11 | 4 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| CHEMBL34166 | 118652 | None | 11 | strain AD169 | Functional | pEC50 | = | 5.5 | 5.5 | -11 | 4 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| 10526132 | 72502 | None | 0 | strain AD169 | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 2 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 419 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm050418d | ||
| CHEMBL142004 | 72502 | None | 0 | strain AD169 | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 2 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 419 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm050418d | ||
| CHEMBL198935 | 72502 | None | 0 | strain AD169 | Functional | pEC50 | = | 5.4 | 5.4 | 1 | 2 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 419 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm050418d | ||
| 11719018 | 72389 | None | 0 | strain AD169 | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm050418d | ||
| CHEMBL198553 | 72389 | None | 0 | strain AD169 | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm050418d | ||
Showing 1 to 15 of 15 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 56679132 | 65188 | None | 0 | strain AD169 | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 281 | 3 | 1 | 2 | 3.0 | CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824272 | 65188 | None | 0 | strain AD169 | Binding | pEC50 | = | 6 | 6.0 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 281 | 3 | 1 | 2 | 3.0 | CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 56679132 | 65188 | None | 0 | strain AD169 | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 281 | 3 | 1 | 2 | 3.0 | CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824272 | 65188 | None | 0 | strain AD169 | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 281 | 3 | 1 | 2 | 3.0 | CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 56668956 | 65186 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 415 | 13 | 1 | 3 | 4.3 | CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824269 | 65186 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 415 | 13 | 1 | 3 | 4.3 | CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 | 10.1016/j.bmcl.2014.06.082 | ||
| 56668956 | 65186 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 415 | 13 | 1 | 3 | 4.3 | CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824269 | 65186 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 415 | 13 | 1 | 3 | 4.3 | CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 | 10.1016/j.bmcl.2014.06.082 | ||
| 56682429 | 65189 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 413 | 6 | 0 | 3 | 4.4 | CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824275 | 65189 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 413 | 6 | 0 | 3 | 4.4 | CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 56682429 | 65189 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 413 | 6 | 0 | 3 | 4.4 | CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824275 | 65189 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 413 | 6 | 0 | 3 | 4.4 | CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 4106 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| 5358812 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| 89 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL93240 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| 4106 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| 5358812 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| 89 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL93240 | 2502 | None | 21 | strain AD169 | Binding | pEC50 | = | 6.5 | 6.5 | - | 33 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 10.1016/j.bmcl.2014.06.082 | ||
| 56665519 | 65187 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 267 | 2 | 1 | 2 | 2.6 | CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824270 | 65187 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 267 | 2 | 1 | 2 | 2.6 | CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 56665519 | 65187 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 267 | 2 | 1 | 2 | 2.6 | CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL1824270 | 65187 | None | 0 | strain AD169 | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 267 | 2 | 1 | 2 | 2.6 | CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 9889700 | 118652 | None | 11 | strain AD169 | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL34166 | 118652 | None | 11 | strain AD169 | Binding | pEC50 | = | 5.4 | 5.4 | - | 1 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 9889700 | 118652 | None | 11 | strain AD169 | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| CHEMBL34166 | 118652 | None | 11 | strain AD169 | Binding | pEC50 | = | 5.3 | 5.3 | - | 1 | Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay |
ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2014.06.082 | ||
| 10410351 | 72380 | None | 0 | strain AD169 | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 428 | 7 | 0 | 2 | 6.8 | N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| CHEMBL198505 | 72380 | None | 0 | strain AD169 | Binding | pIC50 | = | 5.0 | 5.0 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 428 | 7 | 0 | 2 | 6.8 | N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| 11547305 | 141463 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1cccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)c1 | 10.1021/jm050418d | ||
| CHEMBL383822 | 141463 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1cccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)c1 | 10.1021/jm050418d | ||
| 11609863 | 16853 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 343 | 6 | 1 | 2 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 | 10.1021/jm050418d | ||
| CHEMBL124813 | 16853 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 343 | 6 | 1 | 2 | 4.6 | OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 | 10.1021/jm050418d | ||
| 11705066 | 72245 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 449 | 8 | 1 | 3 | 6.2 | COc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 | 10.1021/jm050418d | ||
| CHEMBL198111 | 72245 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 449 | 8 | 1 | 3 | 6.2 | COc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 | 10.1021/jm050418d | ||
| 11569984 | 72330 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 487 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm050418d | ||
| CHEMBL198332 | 72330 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 487 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm050418d | ||
| 11525302 | 72402 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 453 | 7 | 1 | 2 | 6.9 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)cc2)CC1 | 10.1021/jm050418d | ||
| CHEMBL198614 | 72402 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 453 | 7 | 1 | 2 | 6.9 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)cc2)CC1 | 10.1021/jm050418d | ||
| 11642194 | 141232 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 487 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 | 10.1021/jm050418d | ||
| CHEMBL382760 | 141232 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 487 | 7 | 1 | 2 | 7.5 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 | 10.1021/jm050418d | ||
| 10576989 | 72111 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 488 | 7 | 1 | 3 | 6.0 | N#CC(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| CHEMBL197749 | 72111 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 488 | 7 | 1 | 3 | 6.0 | N#CC(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| 11648468 | 133501 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 | 10.1021/jm050418d | ||
| CHEMBL370577 | 133501 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 433 | 7 | 1 | 2 | 6.5 | Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 | 10.1021/jm050418d | ||
| 11510165 | 72314 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 390 | 8 | 0 | 4 | 4.6 | CCOC(=O)C1CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm050418d | ||
| CHEMBL198308 | 72314 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 390 | 8 | 0 | 4 | 4.6 | CCOC(=O)C1CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm050418d | ||
| 10811537 | 71442 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 410 | 7 | 1 | 3 | 5.3 | N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
| CHEMBL195943 | 71442 | None | 0 | strain AD169 | Binding | pIC50 | = | 4.5 | 4.5 | - | 0 | Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 |
ChEMBL | 410 | 7 | 1 | 3 | 5.3 | N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm050418d | ||
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