Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
11648468 140211 0 None - 1 strain AD169 4.9 pEC50 = 4.9 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
CHEMBL370577 140211 0 None - 1 strain AD169 4.9 pEC50 = 4.9 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
10410351 79131 0 None - 1 strain AD169 4.9 pEC50 = 4.9 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198505 79131 0 None - 1 strain AD169 4.9 pEC50 = 4.9 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10811537 78193 0 None - 1 strain AD169 4.6 pEC50 = 4.6 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL195943 78193 0 None - 1 strain AD169 4.6 pEC50 = 4.6 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10670785 39894 0 None - 1 strain AD169 4.5 pEC50 = 4.5 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
CHEMBL141713 39894 0 None - 1 strain AD169 4.5 pEC50 = 4.5 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
9889700 125366 17 None -11 4 strain AD169 5.5 pEC50 = 5.5 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL34166 125366 17 None -11 4 strain AD169 5.5 pEC50 = 5.5 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10526132 79252 0 None 1 2 strain AD169 5.4 pEC50 = 5.4 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL142004 79252 0 None 1 2 strain AD169 5.4 pEC50 = 5.4 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL198935 79252 0 None 1 2 strain AD169 5.4 pEC50 = 5.4 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
11719018 79140 0 None - 1 strain AD169 5.0 pEC50 = 5.0 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d
CHEMBL198553 79140 0 None - 1 strain AD169 5.0 pEC50 = 5.0 Functional
Effective concentration against US28-mediated inositol phosphate production in COS-7 cellsEffective concentration against US28-mediated inositol phosphate production in COS-7 cells
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
56679132 71941 0 None - 0 strain AD169 6.0 pEC50 = 6 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824272 71941 0 None - 0 strain AD169 6.0 pEC50 = 6 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
56679132 71941 0 None - 0 strain AD169 6.0 pEC50 = 6.0 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824272 71941 0 None - 0 strain AD169 6.0 pEC50 = 6.0 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 281 3 1 2 3.0 CC1(CCO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
56668956 71939 0 None - 0 strain AD169 5.8 pEC50 = 5.8 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
CHEMBL1824269 71939 0 None - 0 strain AD169 5.8 pEC50 = 5.8 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
56668956 71939 0 None - 0 strain AD169 5.8 pEC50 = 5.8 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
CHEMBL1824269 71939 0 None - 0 strain AD169 5.8 pEC50 = 5.8 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 415 13 1 3 4.3 CCCCCCCCCC(=O)N(CCN(C)C)CC1(C)Cc2ccccc2C(=O)N1 10.1016/j.bmcl.2014.06.082
56682429 71942 0 None - 0 strain AD169 5.5 pEC50 = 5.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824275 71942 0 None - 0 strain AD169 5.5 pEC50 = 5.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
56682429 71942 0 None - 0 strain AD169 5.5 pEC50 = 5.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824275 71942 0 None - 0 strain AD169 5.5 pEC50 = 5.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 413 6 0 3 4.4 CC1(COC(=O)Cc2ccccc2)Cc2ccccc2CN1C(=O)Cc1ccccc1 10.1016/j.bmcl.2014.06.082
4106 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
5358812 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
89 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
CHEMBL93240 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
4106 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
5358812 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
89 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
CHEMBL93240 9280 22 None - 33 strain AD169 6.5 pEC50 = 6.5 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C 10.1016/j.bmcl.2014.06.082
56665519 71940 0 None - 0 strain AD169 5.4 pEC50 = 5.4 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824270 71940 0 None - 0 strain AD169 5.4 pEC50 = 5.4 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
56665519 71940 0 None - 0 strain AD169 5.4 pEC50 = 5.4 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL1824270 71940 0 None - 0 strain AD169 5.4 pEC50 = 5.4 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 267 2 1 2 2.6 CC1(CO)Cc2ccccc2C(=O)N1c1ccccc1 10.1016/j.bmcl.2014.06.082
9889700 125366 17 None - 1 strain AD169 5.4 pEC50 = 5.4 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL34166 125366 17 None - 1 strain AD169 5.4 pEC50 = 5.4 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
9889700 125366 17 None - 1 strain AD169 5.3 pEC50 = 5.3 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
CHEMBL34166 125366 17 None - 1 strain AD169 5.3 pEC50 = 5.3 Binding
Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assayAllosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2014.06.082
10410351 79131 0 None - 0 strain AD169 5.0 pIC50 = 5.0 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198505 79131 0 None - 0 strain AD169 5.0 pIC50 = 5.0 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 428 7 0 2 6.8 N#CC(CCCN1CCC(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11547305 148154 0 None - 0 strain AD169 4.9 pIC50 = 4.9 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1cccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)c1 10.1021/jm050418d
CHEMBL383822 148154 0 None - 0 strain AD169 4.9 pIC50 = 4.9 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1cccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)c1 10.1021/jm050418d
11609863 23618 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm050418d
CHEMBL124813 23618 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm050418d
11705066 78996 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 449 8 1 3 6.2 COc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
CHEMBL198111 78996 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 449 8 1 3 6.2 COc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
11569984 79081 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm050418d
CHEMBL198332 79081 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm050418d
11525302 79153 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 453 7 1 2 6.9 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
CHEMBL198614 79153 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 453 7 1 2 6.9 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
11642194 147923 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
CHEMBL382760 147923 0 None - 0 strain AD169 4.8 pIC50 = 4.8 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 487 7 1 2 7.5 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccc(Cl)cc2)c2ccc(Cl)cc2)CC1 10.1021/jm050418d
10576989 78862 0 None - 0 strain AD169 4.7 pIC50 = 4.7 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 488 7 1 3 6.0 N#CC(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL197749 78862 0 None - 0 strain AD169 4.7 pIC50 = 4.7 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 488 7 1 3 6.0 N#CC(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11648468 140211 0 None - 0 strain AD169 4.5 pIC50 = 4.5 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
CHEMBL370577 140211 0 None - 0 strain AD169 4.5 pIC50 = 4.5 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccc(C(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2)cc1 10.1021/jm050418d
11510165 79065 0 None - 0 strain AD169 4.5 pIC50 = 4.5 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 390 8 0 4 4.6 CCOC(=O)C1CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL198308 79065 0 None - 0 strain AD169 4.5 pIC50 = 4.5 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 390 8 0 4 4.6 CCOC(=O)C1CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
10811537 78193 0 None - 0 strain AD169 4.5 pIC50 = 4.5 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL195943 78193 0 None - 0 strain AD169 4.5 pIC50 = 4.5 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 410 7 1 3 5.3 N#CC(CCCN1CCC(O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11634351 79071 0 None - 0 strain AD169 4.4 pIC50 = 4.4 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 478 7 1 3 6.6 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(Cl)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198313 79071 0 None - 0 strain AD169 4.4 pIC50 = 4.4 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 478 7 1 3 6.6 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(Cl)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11584791 140335 0 None - 0 strain AD169 4.3 pIC50 = 4.3 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 512 7 1 3 6.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(C(F)(F)F)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL371031 140335 0 None - 0 strain AD169 4.3 pIC50 = 4.3 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 512 7 1 3 6.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)c(C(F)(F)F)c2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
11719018 79140 0 None - 0 strain AD169 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d
CHEMBL198553 79140 0 None - 0 strain AD169 5.3 pIC50 = 5.3 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 433 7 1 2 6.5 Cc1ccccc1C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm050418d
11698316 78847 0 None - 0 strain AD169 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 7 1 3 5.6 Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
CHEMBL197694 78847 0 None - 0 strain AD169 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 7 1 3 5.6 Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
11674616 78840 0 None - 0 strain AD169 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 345 6 1 3 4.1 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccccc2)CC1 10.1021/jm050418d
CHEMBL197675 78840 0 None - 0 strain AD169 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 345 6 1 3 4.1 OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccccc2)CC1 10.1021/jm050418d
11626763 79183 0 None - 0 strain AD169 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 8 1 3 5.3 N#CC(CCCN1CCC(O)(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL198721 79183 0 None - 0 strain AD169 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 424 8 1 3 5.3 N#CC(CCCN1CCC(O)(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
10526132 79252 0 None - 1 strain AD169 5.2 pIC50 = 5.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL142004 79252 0 None - 1 strain AD169 5.2 pIC50 = 5.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
CHEMBL198935 79252 0 None - 1 strain AD169 5.2 pIC50 = 5.2 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 419 7 1 2 6.2 OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm050418d
10670785 39894 0 None - 1 strain AD169 4.1 pIC50 = 4.1 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
CHEMBL141713 39894 0 None - 1 strain AD169 4.1 pIC50 = 4.1 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 440 8 1 4 5.3 COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm050418d
9889700 125366 17 None - 1 strain AD169 5.0 pIC50 = 5.0 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d
CHEMBL34166 125366 17 None - 1 strain AD169 5.0 pIC50 = 5.0 Binding
Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm050418d