Initializing potency table...
Ligand source activities (1 row/activity)
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name | GPCRdb ID | Reference ligand | Vendors | Species | Assay Type | Activity Type | Activity Relation | Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description | Source | Mol weight | Rot Bonds | H don | H acc | LogP | Smiles | DOI | |
α-ergocryptine | 358 | None | 18 | Human | Binding | Ki | = | 24.00 | 7.62 | -10 | 21 | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL | 575.3 | 5 | 3 | 6 | 2.43 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | - | |
α-ergocryptine | 358 | None | 18 | Human | Binding | pKi | = | 8.37 | 8.08 | -10 | 21 | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | Drug Central | 575.3 | 5 | 3 | 6 | 2.43 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | - | |
α-ergocryptine | 358 | None | 18 | Human | Binding | IC50 | = | 48.00 | 7.32 | -10 | 21 | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL | 575.3 | 5 | 3 | 6 | 2.43 | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | - | |
(±)-adrenaline | 3139 | None | 60 | Human | Binding | pKi | = | 6.00 | 8.22 | -1 | 14 | None | Drug Central | 183.1 | 3 | 4 | 4 | 0.35 | CNCC(O)c1ccc(O)c(O)c1 | - | |
(±)-adrenaline | 3139 | 125I-HEAT | 60 | Rat | Binding | pKi | = | 10000.00 | 5.00 | -1995 | 14 | - | PDSP KiDatabase | 183.1 | 3 | 4 | 4 | 0.35 | CNCC(O)c1ccc(O)c(O)c1 | - | |
(+)-adrenaline | 290 | None | 26 | Human | Binding | pKi | = | - | 6.00 | 3 | 5 | Unclassified | Guide to Pharmacology | 183.1 | 3 | 4 | 4 | 0.35 | CNC[C@@H](O)c1ccc(O)c(O)c1 | https://pubmed.ncbi.nlm.nih.gov/7651358 | |
(+)-chlorpheniramine | 918 | None | 42 | Human | Binding | Ki | = | 16575.00 | 4.78 | -602 | 27 | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL | 274.1 | 5 | 0 | 2 | 3.82 | CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1 | - | |
(+)-chlorpheniramine | 918 | None | 42 | Human | Binding | IC50 | = | 33721.00 | 4.47 | -602 | 27 | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | ChEMBL | 274.1 | 5 | 0 | 2 | 3.82 | CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1 | - | |
(+)-chlorpheniramine | 918 | None | 42 | Human | Binding | pKi | = | 4.78 | 8.32 | -602 | 27 | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | Drug Central | 274.1 | 5 | 0 | 2 | 3.82 | CN(C)CC[C@@H](c1ccc(Cl)cc1)c1ccccn1 | - | |
(+)-cyclazosin | 1278 | None | 10 | Human | Binding | Ki | = | 31.62 | 7.50 | -5 | 9 | Binding affinity was tested on cloned rat Alpha-1D adrenergic receptor | ChEMBL | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC | https://dx.doi.org/10.1021/jm960697s | |
(+)-cyclazosin | 1278 | None | 10 | Human | Binding | Ki | = | 0.17 | 9.77 | -5 | 9 | Displacement of [3H]prazosin from human Alpha-1D adrenoceptor expressed in CHO cells | ChEMBL | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC | https://dx.doi.org/10.1021/jm8016046 | |
(+)-CYCLAZOSIN | 85391 | None | 0 | Human | Binding | Ki | = | 3.24 | 8.49 | -15 | 5 | Displacement of [3H]prazosin from Homo sapiens (human) alpha1D adrenergic receptor | ChEMBL | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC | https://dx.doi.org/10.1007/s00044-004-0024-8 | |
(+)-cyclazosin | 1278 | None | 10 | Human | Binding | Ki | = | 3.24 | 8.49 | -5 | 9 | Displacement of [3H]prazosin from human alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins by rapid filtration method | ChEMBL | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC | https://dx.doi.org/10.1016/j.bmc.2018.05.023 | |
(+)-cyclazosin | 1278 | None | 10 | Human | Binding | Ki | = | 3.24 | 8.49 | -5 | 9 | Displacement of [3H]prazosin from human adrenergic alpha-1d receptor expressed in CHO cells | ChEMBL | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC | https://dx.doi.org/10.1016/j.bmc.2007.01.028 | |
(+)-cyclazosin | 1278 | None | 10 | Human | Binding | pKi | = | - | 9.20 | -5 | 9 | Unclassified | Guide to Pharmacology | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC | https://pubmed.ncbi.nlm.nih.gov/8917649 | |
(+)-cyclazosin | 1278 | None | 10 | Human | Binding | pKi | = | - | 9.20 | -5 | 9 | Unclassified | Guide to Pharmacology | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC | https://pubmed.ncbi.nlm.nih.gov/32608144 | |
(+)-cyclazosin | 1278 | None | 10 | Rat | Binding | pKi | None | - | 7.60 | -79 | 9 | Unclassified | Guide to Pharmacology | 437.2 | 4 | 1 | 8 | 3.10 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC | https://pubmed.ncbi.nlm.nih.gov/8917649 | |
(-)-adrenaline | 291 | None | 40 | Human | Binding | pKi | = | - | 6.25 | -17 | 35 | Unclassified | Guide to Pharmacology | 183.1 | 3 | 4 | 4 | 0.35 | CNC[C@H](O)c1ccc(O)c(O)c1 | https://pubmed.ncbi.nlm.nih.gov/7651358 | |
(-)-adrenaline | 291 | None | 40 | Human | Binding | pKi | = | - | 6.25 | -17 | 35 | Unclassified | Guide to Pharmacology | 183.1 | 3 | 4 | 4 | 0.35 | CNC[C@H](O)c1ccc(O)c(O)c1 | https://pubmed.ncbi.nlm.nih.gov/8564227 | |
(-)-adrenaline | 291 | None | 40 | Human | Binding | pKi | = | - | 6.25 | -17 | 35 | Unclassified | Guide to Pharmacology | 183.1 | 3 | 4 | 4 | 0.35 | CNC[C@H](O)c1ccc(O)c(O)c1 | https://pubmed.ncbi.nlm.nih.gov/34355529 |
Showing 1 to 20 of 2,216 entries
Ligands | Receptor | Activity | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Common name |
GPCRdb ID |
Reference ligand |
Vendors | Species | Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI | |