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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

BMS compound 16 [PMID:23368907]	690	None	42	Human	Binding	Ki	=	3500.00	5.46	-128	2	Inhibition of human P2Y14 receptor	ChEMBL	445.2	5	2	4	6.71	CC(C)(C)c1ccccc1Oc1ncccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1	https://dx.doi.org/10.1021/jm301708u
CHEMBL1771456	61701	None	0	Human	Binding	Ki	=	160.00	6.80	-	2	Antagonist activity at human recombinant P2Y14 assessed as inhibition constant	ChEMBL	492.2	4	1	5	6.00	CCc1cccc(NC(=O)N2CCc3nc(-c4ccc5c(c4)OCO5)nc(-c4ccccc4C)c3C2)c1	https://dx.doi.org/10.1021/acs.jmedchem.5b01972
CHEMBL1774882	62074	None	0	Human	Binding	IC50	=	3500.00	5.46	-	2	Antagonist activity at human P2Y14 using UDP-Glc as substrate	ChEMBL	354.1	5	1	2	5.78	O=C(O)c1cc(-c2ccccc2)c2ccc(OCc3ccccc3)cc2c1	https://dx.doi.org/10.1021/acs.jmedchem.5b01972
CHEMBL1774892	62082	None	0	Mouse	Binding	IC50	=	14.00	7.85	-	1	Inhibition of mouse P2Y14 receptor	ChEMBL	406.1	5	1	3	6.60	Cc1cc(F)cc(C)c1COc1ccc2c(-c3ccsc3)cc(C(=O)O)cc2c1	https://dx.doi.org/10.1016/j.ejmech.2019.04.068
CHEMBL1774903	62093	None	0	Mouse	Binding	Ki	=	1290.00	5.89	-	1	Inhibition of mouse P2Y14 receptor in presence of 2% HSA	ChEMBL	472.1	5	2	2	7.19	O=C(O)c1cc(-c2ccc([C@@H](O)C(F)F)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	https://dx.doi.org/10.1016/j.ejmech.2019.04.068
CHEMBL1774903	62093	None	0	Mouse	Binding	Ki	=	4.00	8.40	-	1	Inhibition of mouse P2Y14 receptor	ChEMBL	472.1	5	2	2	7.19	O=C(O)c1cc(-c2ccc([C@@H](O)C(F)F)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	https://dx.doi.org/10.1016/j.ejmech.2019.04.068
CHEMBL228111	85611	None	4	Human	Binding	EC50	=	11000.00	4.96	-	1	Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta	ChEMBL	582.0	9	9	16	-3.42	O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H]2O)c(=S)[nH]1	https://dx.doi.org/10.1016/j.bmc.2015.03.042
CHEMBL2333767	87497	None	0	Human	Binding	Ki	=	2350.00	5.63	-117	3	Inhibition of human P2Y14 receptor	ChEMBL	391.2	4	2	3	6.48	Cc1ccc(NC(=O)Nc2cccnc2Sc2ccccc2C(C)(C)C)cc1	https://dx.doi.org/10.1021/jm301708u
CHEMBL2333771	87499	None	0	Human	Binding	Ki	=	5950.00	5.22	-758	2	Inhibition of human P2Y14 receptor	ChEMBL	417.2	4	2	3	7.11	CC(C)(C)c1ccc(NC(=O)Nc2cccnc2Oc2ccccc2C(C)(C)C)cc1	https://dx.doi.org/10.1021/jm301708u
CHEMBL2333773	87501	None	0	Human	Binding	Ki	=	3300.00	5.48	-208	3	Inhibition of human P2Y14 receptor	ChEMBL	431.1	6	2	4	6.54	CC(C)c1ccccc1Oc1ncccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1	https://dx.doi.org/10.1021/jm301708u
CHEMBL3606064	122981	None	0	Human	Binding	IC50	=	362.00	6.44	-	2	Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)-phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate from recombinant human P2Y14 receptor expressed in CHO cells preincubated for 30 mins followed by tracer addition and measured after 30 mins by flow cytometry	ChEMBL	420.0	6	6	9	-2.37	O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)cc1F	https://dx.doi.org/10.1021/acs.jmedchem.9b00164
CHEMBL3606064	122981	None	0	Human	Binding	IC50	=	362.00	6.44	-	2	Binding affinity to human P2Y14 expressed in CHO cells	ChEMBL	420.0	6	6	9	-2.37	O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)cc1F	https://dx.doi.org/10.1016/j.bmcl.2021.128137
CHEMBL4203557	163693	None	0	Human	Binding	IC50	=	1960.00	5.71	-	1	Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method	ChEMBL	513.1	6	2	7	4.79	O=C(O)c1cc(-c2ccc(CN3CCNCC3)s2)cc(-n2cc(-c3ccc(C(F)(F)F)cc3)nn2)c1	https://dx.doi.org/10.1021/acs.jmedchem.8b00168
CHEMBL4204323	163748	None	1	Human	Binding	IC50	=	16400.00	4.79	-	1	Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method	ChEMBL	349.1	3	2	5	3.36	O=C(O)c1cc(O)cc(-n2cc(-c3ccc(C(F)(F)F)cc3)nn2)c1	https://dx.doi.org/10.1021/acs.jmedchem.8b00168
CHEMBL4204678	163772	None	0	Human	Binding	IC50	=	5920.00	5.23	-	1	Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method	ChEMBL	637.1	9	3	9	5.18	CC(C)(C)OC(=O)NCCNS(=O)(=O)c1ccc(-c2cc(C(=O)O)cc(-n3cc(-c4ccc(C(F)(F)F)cc4)nn3)c2)s1	https://dx.doi.org/10.1021/acs.jmedchem.8b00168
CHEMBL4204741	163776	None	0	Human	Binding	IC50	=	2180.00	5.66	-	1	Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method	ChEMBL	565.1	10	3	8	4.40	NCCCCNS(=O)(=O)c1ccc(-c2cc(C(=O)O)cc(-n3cc(-c4ccc(C(F)(F)F)cc4)nn3)c2)s1	https://dx.doi.org/10.1021/acs.jmedchem.8b00168
CHEMBL4204811	163783	None	0	Human	Binding	IC50	=	10900.00	4.96	-	1	Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method	ChEMBL	499.1	8	3	7	3.99	NCCCNC(=O)c1ccc(-c2cc(C(=O)O)cc(-n3cc(-c4ccc(C(F)(F)F)cc4)nn3)c2)o1	https://dx.doi.org/10.1021/acs.jmedchem.8b00168
CHEMBL4205190	163821	None	0	Human	Binding	IC50	=	3200.00	5.50	-	2	Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method	ChEMBL	332.1	2	2	2	4.93	O=C(O)c1cc(O)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	https://dx.doi.org/10.1021/acs.jmedchem.8b00168
CHEMBL4205190	163821	None	0	Human	Binding	IC50	=	3200.00	5.50	-	2	Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from human P2Y14 expressed in CHO cells measured after 30 mins by FACScalibur flow cytometry analysis	ChEMBL	332.1	2	2	2	4.93	O=C(O)c1cc(O)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	https://dx.doi.org/10.1021/acsmedchemlett.0c00115
CHEMBL4205190	163821	None	0	Mouse	Binding	IC50	=	1600.00	5.80	-	2	Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from HA-tagged mouse P2Y14 expressed in HEK293 cells measured after 30 mins by FACScalibur flow cytometry analysis	ChEMBL	332.1	2	2	2	4.93	O=C(O)c1cc(O)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	https://dx.doi.org/10.1021/acsmedchemlett.0c00115

Showing 1 to 20 of 288 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)