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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL2181246	83043	None	0	Human	Binding	EC50	=	10.00	8.00	-	2	Agonist activity at TGR5 (unknown origin)	ChEMBL	398.1	3	0	3	5.77	O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21	https://dx.doi.org/10.1016/j.ejmech.2013.07.050
CHEMBL2181246	83043	None	0	Human	Binding	EC50	=	10.00	8.00	-	2	Agonist activity at human TGR5	ChEMBL	398.1	3	0	3	5.77	O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21	https://dx.doi.org/10.1021/acs.jmedchem.5b00342
CHEMBL2181246	83043	None	0	Human	Binding	EC50	=	10.00	8.00	-	2	Agonist activity at GPBAR1 in human NCI-H716 cells	ChEMBL	398.1	3	0	3	5.77	O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21	https://dx.doi.org/10.1021/acs.jmedchem.5b01875
CHEMBL2181246	83043	None	0	Mouse	Binding	EC50	=	2560.00	5.59	-	2	Agonist activity at mouse TGR5	ChEMBL	398.1	3	0	3	5.77	O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21	https://dx.doi.org/10.1021/acs.jmedchem.5b00342
CHEMBL2407929	91636	None	0	Human	Binding	EC50	=	57.00	7.24	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	450.2	7	2	4	6.46	Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407929	91636	None	0	Mouse	Binding	EC50	=	190.00	6.72	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	450.2	7	2	4	6.46	Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407930	91637	None	4	Human	Binding	EC50	=	4.00	8.40	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	457.2	7	2	5	5.40	Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407930	91637	None	4	Mouse	Binding	EC50	=	28.00	7.55	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	457.2	7	2	5	5.40	Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407931	91638	None	0	Human	Binding	EC50	=	23.00	7.64	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	457.2	7	2	5	5.40	Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407931	91638	None	0	Mouse	Binding	EC50	=	130.00	6.89	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	457.2	7	2	5	5.40	Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407932	91639	None	0	Human	Binding	EC50	=	60.00	7.22	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	466.2	7	2	5	5.46	Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407932	91639	None	0	Mouse	Binding	EC50	=	450.00	6.35	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	466.2	7	2	5	5.46	Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407933	91640	None	0	Human	Binding	EC50	=	320.00	6.50	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	466.2	7	2	5	5.46	Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407933	91640	None	0	Mouse	Binding	EC50	=	620.00	6.21	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	466.2	7	2	5	5.46	Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407934	91641	None	0	Human	Binding	EC50	=	26.00	7.58	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	424.1	6	1	6	3.50	Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407934	91641	None	0	Mouse	Binding	EC50	=	1300.00	5.89	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	424.1	6	1	6	3.50	Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407935	91642	None	0	Human	Binding	EC50	=	80.00	7.10	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	424.1	6	1	6	3.50	Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407935	91642	None	0	Mouse	Binding	EC50	=	3000.00	5.52	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	424.1	6	1	6	3.50	Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407936	91643	None	0	Human	Binding	EC50	=	45.00	7.35	-	2	Agonist activity at recombinant human GPBAR1 expressed in CHO cells	ChEMBL	345.2	6	1	4	4.55	CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017
CHEMBL2407936	91643	None	0	Mouse	Binding	EC50	=	2000.00	5.70	-	2	Agonist activity at recombinant mouse GPBAR1 expressed in CHO cells	ChEMBL	345.2	6	1	4	4.55	CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1	https://dx.doi.org/10.1016/j.bmcl.2013.06.017

Showing 1 to 20 of 104 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)