Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 122195891 | 124264 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -269 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 489 | 7 | 6 | 13 | -0.1 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | 10.1021/acs.jmedchem.5b00575 | ||
| CHEMBL3634182 | 124264 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -269 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 489 | 7 | 6 | 13 | -0.1 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1 | 10.1021/acs.jmedchem.5b00575 | ||
| 122195895 | 124268 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -11 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 477 | 6 | 6 | 12 | -0.2 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)S)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b00575 | ||
| CHEMBL3634186 | 124268 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -11 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 477 | 6 | 6 | 12 | -0.2 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)S)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b00575 | ||
| 73351984 | 90415 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -1 | 2 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 457 | 6 | 5 | 12 | -1.5 | B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)O | 10.1021/jm400197m | ||
| CHEMBL2386492 | 90415 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -1 | 2 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 457 | 6 | 5 | 12 | -1.5 | B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)O | 10.1021/jm400197m | ||
| 122195893 | 124266 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -3 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 557 | 8 | 7 | 14 | -0.0 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b00575 | ||
| CHEMBL3634184 | 124266 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -3 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 557 | 8 | 7 | 14 | -0.0 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b00575 | ||
| 23656760 | 14718 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level |
ChEMBL | 974 | 9 | 4 | 10 | 10.0 | O=S(=O)(O)OC(=C\c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)/C(=C/c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)OS(=O)(=O)O | 10.1021/jm070043r | ||
| CHEMBL1206193 | 14718 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level |
ChEMBL | 974 | 9 | 4 | 10 | 10.0 | O=S(=O)(O)OC(=C\c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)/C(=C/c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)OS(=O)(=O)O | 10.1021/jm070043r | ||
| CHEMBL240681 | 14718 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level |
ChEMBL | 974 | 9 | 4 | 10 | 10.0 | O=S(=O)(O)OC(=C\c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)/C(=C/c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)OS(=O)(=O)O | 10.1021/jm070043r | ||
| 73353445 | 90419 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 7 | 2 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 603 | 8 | 6 | 13 | -0.1 | B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O | 10.1021/jm400197m | ||
| CHEMBL2386496 | 90419 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 7 | 2 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 603 | 8 | 6 | 13 | -0.1 | B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O | 10.1021/jm400197m | ||
| 56941832 | 76808 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -42 | 2 | Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis |
ChEMBL | 908 | 16 | 10 | 25 | -2.5 | BP(=O)(OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | 10.1021/jm100597c | ||
| CHEMBL1802094 | 76808 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -42 | 2 | Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis |
ChEMBL | 908 | 16 | 10 | 25 | -2.5 | BP(=O)(OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | 10.1021/jm100597c | ||
| CHEMBL2068734 | 76808 | None | 0 | Human | Functional | pEC50 | = | 4.9 | 4.9 | -42 | 2 | Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis |
ChEMBL | 908 | 16 | 10 | 25 | -2.5 | BP(=O)(OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | 10.1021/jm100597c | ||
| 122195892 | 124265 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -3 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 477 | 6 | 6 | 12 | -0.2 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b00575 | ||
| CHEMBL3634183 | 124265 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -3 | 2 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 477 | 6 | 6 | 12 | -0.2 | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O | 10.1021/acs.jmedchem.5b00575 | ||
| 73347374 | 90418 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -9 | 2 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 603 | 8 | 6 | 13 | -0.1 | B[P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O | 10.1021/jm400197m | ||
| CHEMBL2386495 | 90418 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -9 | 2 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 603 | 8 | 6 | 13 | -0.1 | B[P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O | 10.1021/jm400197m | ||
| 1756 | 463 | None | 9 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -38 | 2 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 647 | 11 | 7 | 14 | 1.1 | CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/jm020046y | ||
| 5310954 | 463 | None | 9 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -38 | 2 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 647 | 11 | 7 | 14 | 1.1 | CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/jm020046y | ||
| CHEMBL336292 | 463 | None | 9 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -38 | 2 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 647 | 11 | 7 | 14 | 1.1 | CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O | 10.1021/jm020046y | ||
| 73354953 | 90414 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 577 | 9 | 5 | 14 | 0.8 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@H](O)[C@H]3OC(=O)c3ccccc3)c2n1 | 10.1021/jm400197m | ||
| CHEMBL2386490 | 90414 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 577 | 9 | 5 | 14 | 0.8 | CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@H](O)[C@H]3OC(=O)c3ccccc3)c2n1 | 10.1021/jm400197m | ||
| 135973538 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| 1728 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| 2966 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| 4261196 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| 5361 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| 5361.0 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| CHEMBL265502 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| DB04786 | 3710 | None | 26 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -2 | 10 | The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm020046y | ||
| 1712 | 288 | None | 48 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -41 | 6 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/acs.jmedchem.5b00575 | ||
| 6022 | 288 | None | 48 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -41 | 6 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/acs.jmedchem.5b00575 | ||
| CHEMBL14830 | 288 | None | 48 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -41 | 6 | Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay |
ChEMBL | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/acs.jmedchem.5b00575 | ||
| 1712 | 288 | None | 48 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -41 | 6 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm400197m | ||
| 6022 | 288 | None | 48 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -41 | 6 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm400197m | ||
| CHEMBL14830 | 288 | None | 48 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -41 | 6 | Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay |
ChEMBL | 427 | 6 | 6 | 12 | -1.7 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm400197m | ||
| 1713 | 520 | None | 42 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -165 | 10 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm020046y | ||
| 5957 | 520 | None | 42 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -165 | 10 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm020046y | ||
| 91 | 520 | None | 42 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -165 | 10 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm020046y | ||
| CHEMBL14249 | 520 | None | 42 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -165 | 10 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm020046y | ||
| DB00171 | 520 | None | 42 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -165 | 10 | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) |
ChEMBL | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm020046y | ||
| 10994891 | 78460 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -194 | 4 | Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM |
ChEMBL | 517 | 8 | 7 | 13 | -1.0 | Nc1ncnc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C[C@H]12 | 10.1021/jm010369e | ||
| CHEMBL2111533 | 78460 | None | 0 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -194 | 4 | Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM |
ChEMBL | 517 | 8 | 7 | 13 | -1.0 | Nc1ncnc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C[C@H]12 | 10.1021/jm010369e | ||
| 6083 | 207273 | None | 55 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -34 | 7 | Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM |
ChEMBL | 347 | 4 | 5 | 10 | -1.9 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O | 10.1021/jm010369e | ||
| CHEMBL1315633 | 207273 | None | 55 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -34 | 7 | Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM |
ChEMBL | 347 | 4 | 5 | 10 | -1.9 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O | 10.1021/jm010369e | ||
| CHEMBL752 | 207273 | None | 55 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -34 | 7 | Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM |
ChEMBL | 347 | 4 | 5 | 10 | -1.9 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O | 10.1021/jm010369e | ||
| 1713 | 520 | None | 42 | Human | Functional | pEC50 | = | 4.8 | 4.8 | -165 | 10 | Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11 |
ChEMBL | 507 | 8 | 7 | 14 | -1.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N | 10.1021/jm010538v | ||
Showing 1 to 50 of 190 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 11636757 | 2810 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7) |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 136776947 | 2810 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7) |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 1761 | 2810 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7) |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| CHEMBL1207514 | 2810 | None | 4 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 1 | Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7) |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 136825091 | 14968 | None | 1 | Human | Binding | pKi | = | 6 | 6.0 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1324 | 18 | 12 | 17 | 7.3 | CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1 | 10.1021/jm050301p | ||
| 451869 | 14968 | None | 1 | Human | Binding | pKi | = | 6 | 6.0 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1324 | 18 | 12 | 17 | 7.3 | CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL1208520 | 14968 | None | 1 | Human | Binding | pKi | = | 6 | 6.0 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1324 | 18 | 12 | 17 | 7.3 | CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL276295 | 14968 | None | 1 | Human | Binding | pKi | = | 6 | 6.0 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1324 | 18 | 12 | 17 | 7.3 | CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1 | 10.1021/jm050301p | ||
| 11564437 | 14870 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1336 | 16 | 12 | 17 | 7.4 | O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1 | 10.1021/jm050301p | ||
| CHEMBL1207516 | 14870 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1336 | 16 | 12 | 17 | 7.4 | O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1 | 10.1021/jm050301p | ||
| CHEMBL413180 | 14870 | None | 0 | Human | Binding | pKi | = | 7.0 | 7.0 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1336 | 16 | 12 | 17 | 7.4 | O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1 | 10.1021/jm050301p | ||
| 135973538 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 1728 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 2966 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 4261196 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 5361 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 5361.0 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| CHEMBL265502 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| DB04786 | 3710 | None | 26 | Human | Binding | pKi | = | 7.0 | 7.0 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| CHEMBL5289838 | 194776 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Antagonist activity at P2Y11 (unknown origin)Antagonist activity at P2Y11 (unknown origin) |
ChEMBL | 906 | 10 | 16 | 7 | 6.0 | Cc1ccc(C(=O)Nc2cc([SH](=O)(O)O)cc3ccc([SH](=O)(O)O)cc23)cc1NC(=O)Nc1cc(C(=O)Nc2cc([SH](=O)(O)O)cc3ccc([SH](=O)(O)O)cc23)ccc1C | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL5316131 | 194776 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Antagonist activity at P2Y11 (unknown origin)Antagonist activity at P2Y11 (unknown origin) |
ChEMBL | 906 | 10 | 16 | 7 | 6.0 | Cc1ccc(C(=O)Nc2cc([SH](=O)(O)O)cc3ccc([SH](=O)(O)O)cc23)cc1NC(=O)Nc1cc(C(=O)Nc2cc([SH](=O)(O)O)cc3ccc([SH](=O)(O)O)cc23)ccc1C | 10.1021/acs.jmedchem.5b01972 | ||
| 11679781 | 14867 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4 |
ChEMBL | 1356 | 20 | 12 | 19 | 6.4 | COCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3COC)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL1207473 | 14867 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4 |
ChEMBL | 1356 | 20 | 12 | 19 | 6.4 | COCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3COC)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL409304 | 14867 | None | 0 | Human | Binding | pKi | = | 5.6 | 5.6 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4 |
ChEMBL | 1356 | 20 | 12 | 19 | 6.4 | COCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3COC)c2)c1 | 10.1021/jm050301p | ||
| 16163320 | 14752 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1420 | 18 | 12 | 17 | 9.5 | O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1 | 10.1021/jm050301p | ||
| CHEMBL1206368 | 14752 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1420 | 18 | 12 | 17 | 9.5 | O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1 | 10.1021/jm050301p | ||
| CHEMBL266646 | 14752 | None | 0 | Human | Binding | pKi | = | 6.5 | 6.5 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1420 | 18 | 12 | 17 | 9.5 | O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1 | 10.1021/jm050301p | ||
| 135973538 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 1728 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 2966 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 4261196 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 5361 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 5361.0 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| CHEMBL265502 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| DB04786 | 3710 | None | 26 | Human | Binding | pKi | = | 6.5 | 6.5 | -1 | 2 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6 |
ChEMBL | 1296 | 16 | 12 | 17 | 6.7 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 11636757 | 2810 | None | 4 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 136776947 | 2810 | None | 4 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 1761 | 2810 | None | 4 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| CHEMBL1207514 | 2810 | None | 4 | Human | Binding | pKi | = | 7.4 | 7.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1304 | 16 | 12 | 17 | 6.4 | O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O | 10.1021/jm050301p | ||
| 10080219 | 14861 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1352 | 18 | 12 | 17 | 8.4 | CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1 | 10.1021/jm050301p | ||
| 136825093 | 14861 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1352 | 18 | 12 | 17 | 8.4 | CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL1207434 | 14861 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1352 | 18 | 12 | 17 | 8.4 | CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL405500 | 14861 | None | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1352 | 18 | 12 | 17 | 8.4 | CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1 | 10.1021/jm050301p | ||
| 16155350 | 14871 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1328 | 18 | 12 | 19 | 6.1 | COc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3OC)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL1207525 | 14871 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1328 | 18 | 12 | 19 | 6.1 | COc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3OC)c2)c1 | 10.1021/jm050301p | ||
| CHEMBL413910 | 14871 | None | 0 | Human | Binding | pKi | = | 7.1 | 7.1 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7 |
ChEMBL | 1328 | 18 | 12 | 19 | 6.1 | COc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3OC)c2)c1 | 10.1021/jm050301p | ||
| 136880426 | 14869 | None | 2 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1058 | 12 | 10 | 15 | 4.2 | Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C | 10.1021/jm050301p | ||
| 369605 | 14869 | None | 2 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1058 | 12 | 10 | 15 | 4.2 | Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C | 10.1021/jm050301p | ||
| CHEMBL1207502 | 14869 | None | 2 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1058 | 12 | 10 | 15 | 4.2 | Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C | 10.1021/jm050301p | ||
| CHEMBL411554 | 14869 | None | 2 | Human | Binding | pKi | = | 5.1 | 5.1 | - | 1 | Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 |
ChEMBL | 1058 | 12 | 10 | 15 | 4.2 | Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C | 10.1021/jm050301p | ||
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