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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(1R,2S)-PHENYLPROPANOLAMINE	27120	Functional	13	Rat	Binding	pKi	=	10000.00	5.00	-38	42	-	PDSP KiDatabase	151.1	2	2	2	1.07	C[C@H](N)[C@H](O)c1ccccc1	-
(1S,3R)-ACPD	33	None	30	Human	Binding	EC50	=	39000.00	4.41	-61	15	Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1016/s0960-894x(00)00247-x
(1S,3R)-ACPD	33	None	30	Rat	Binding	EC50	=	39000.00	4.41	-	15	Concentration for half maximal activation of metabotropic glutamate mGluR4a in rat	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm00009a001
(R,S)-4-PPG	2073	None	26	Human	Binding	EC50	=	4700.00	5.33	-25	7	Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay	ChEMBL	231.0	3	4	3	-0.43	NC(C(=O)O)c1ccc(P(=O)(O)O)cc1	https://dx.doi.org/10.1016/s0960-894x(00)00247-x
1S, 3R-ACPD	218660	Functional	0	Rat	Binding	pKi	=	10000.00	5.00	-2	7	-	PDSP KiDatabase	173.1	2	3	3	-0.35	NC1(C(=O)O)CCC(C(=O)O)C1	-
1S, 3R-ACPD	218660	Functional	0	Rat	Binding	pKi	=	10000.00	5.00	-2	7	-	PDSP KiDatabase	173.1	2	3	3	-0.35	NC1(C(=O)O)CCC(C(=O)O)C1	-
1S, 3R-ACPD	218660	Functional	0	Rat	Binding	pKi	=	10000.00	5.00	-2	7	-	PDSP KiDatabase	173.1	2	3	3	-0.35	NC1(C(=O)O)CCC(C(=O)O)C1	-
ACPT-I	265	None	24	Human	Binding	EC50	=	7000.00	5.16	-	7	Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay	ChEMBL	217.1	3	4	4	-1.04	N[C@@]1(C(=O)O)C[C@H](C(=O)O)[C@H](C(=O)O)C1	https://dx.doi.org/10.1016/s0960-894x(00)00247-x
ADX88178	300	None	40	Human	Binding	pKi	=	-	7.40	-	4	Unclassified	Guide to Pharmacology	272.1	3	2	6	2.68	Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1	https://pubmed.ncbi.nlm.nih.gov/22787118
ADX88178	300	None	40	Human	Binding	EC50	=	52.00	7.28	-	4	Positive allosteric modulation of mGluR4 (unknown origin)	ChEMBL	272.1	3	2	6	2.68	Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1	https://dx.doi.org/10.1016/j.bmcl.2022.129106
ADX88178	300	None	40	Human	Binding	EC50	=	4.00	8.40	-	4	Positive allosteric modulator activity at human mGlu4 receptor	ChEMBL	272.1	3	2	6	2.68	Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1	https://dx.doi.org/10.1016/j.bmcl.2015.07.031
ADX88178	300	None	40	Rat	Binding	EC50	=	9.00	8.05	-	4	Positive allosteric modulator activity at rat mGlu4 receptor	ChEMBL	272.1	3	2	6	2.68	Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1	https://dx.doi.org/10.1016/j.bmcl.2015.07.031
Cathinone, (-)	218812	Functional	0	Rat	Binding	pKi	=	10000.00	5.00	-13	40	-	PDSP KiDatabase	149.1	2	1	2	1.22	CC(N)C(=O)c1ccccc1	-
CHEMBL1223083	15872	None	0	Human	Binding	EC50	=	162.00	6.79	-	1	Positive allosteric modulation of human mGlu4 receptor	ChEMBL	387.0	5	2	4	3.79	O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)cc1)c1ccccn1	https://dx.doi.org/10.1016/j.bmcl.2016.05.029
CHEMBL1223381	15977	None	52	Human	Binding	EC50	=	20.00	7.70	-	1	Positive allosteric modulator activity at human mGlu4 receptor	ChEMBL	421.0	5	2	4	4.44	O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)c(Cl)c1)c1ccccn1	https://dx.doi.org/10.1016/j.bmcl.2015.07.031
CHEMBL1223381	15977	None	52	Human	Binding	EC50	=	19.80	7.70	-	1	Positive allosteric modulation of human mGlu4 receptor	ChEMBL	421.0	5	2	4	4.44	O=C(Nc1ccc(S(=O)(=O)Nc2ccccc2Cl)c(Cl)c1)c1ccccn1	https://dx.doi.org/10.1016/j.bmcl.2016.05.029
CHEMBL1223384	15979	None	0	Human	Binding	EC50	=	237.00	6.62	-	1	Positive allosteric modulation of human mGlu4 receptor	ChEMBL	386.0	5	1	4	3.96	O=C(Nc1ccc(S(=O)(=O)Cc2ccccc2Cl)cc1)c1ccccn1	https://dx.doi.org/10.1016/j.bmcl.2016.05.029
CHEMBL1300476	19647	None	3	Human	Binding	IC50	=	4.90	8.31	-	1	Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting method	ChEMBL	244.1	3	1	3	3.06	CSc1cccc(NC(=O)c2ccccn2)c1	https://dx.doi.org/10.1016/j.bmcl.2015.07.031
CHEMBL1300476	19647	None	3	Human	Binding	IC50	=	4.90	8.31	-	1	Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting method	ChEMBL	244.1	3	1	3	3.06	CSc1cccc(NC(=O)c2ccccn2)c1	https://dx.doi.org/10.1016/j.bmcl.2015.07.031
CHEMBL1346011	24959	None	16	Rat	Binding	EC50	=	1100.00	5.96	-	2	Positive allosteric modulation of rat mGlu4 receptor expressed in human HEK293 cells co-expressing GIRK potassium channels assessed as potentiation of carbachol-induced thallium flux measured between 10 to 20 secs	ChEMBL	322.0	4	2	4	3.12	O=C(COc1ccccc1Br)c1ccc(O)cc1O	https://dx.doi.org/10.1016/j.bmcl.2011.09.131

Showing 1 to 20 of 256 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

(1S,3R)-ACPD	33	None	30	Human	Functional	Ki	=	98000.00	4.01	-10	15	Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).	ChEMBL	173.1	2	3	3	-0.35	N[C@@]1(C(=O)O)CC[C@@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm000007r
(R,S)-4-PPG	2073	None	26	Human	Functional	pEC50	None	-	5.30	-22	7	Unclassified	Guide to Pharmacology	231.0	3	4	3	-0.43	NC(C(=O)O)c1ccc(P(=O)(O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/10336568
(R,S)-4-PPG	2073	None	26	Human	Functional	pEC50	None	-	5.30	-22	7	Unclassified	Guide to Pharmacology	231.0	3	4	3	-0.43	NC(C(=O)O)c1ccc(P(=O)(O)O)cc1	https://pubmed.ncbi.nlm.nih.gov/10866390
(R,S)-4-PPG	2073	None	26	Human	Functional	EC50	=	5200.00	5.28	-22	7	Compound was evaluated for the inhibition of forskolin stimulated cAMP accumulation in CHO cells expressing hmGluR4a	ChEMBL	231.0	3	4	3	-0.43	NC(C(=O)O)c1ccc(P(=O)(O)O)cc1	https://dx.doi.org/10.1016/s0960-894x(00)00197-9
(R,S)-4-PPG	2073	None	26	Human	Functional	EC50	=	3200.00	5.50	-22	7	Compound was evaluated for the inhibition of forskolin stimulated cAMP accumulation in CHO cells expressing hmGluR4a	ChEMBL	231.0	3	4	3	-0.43	NC(C(=O)O)c1ccc(P(=O)(O)O)cc1	https://dx.doi.org/10.1016/s0960-894x(00)00197-9
(R,S)-4-PPG	2073	None	26	Human	Functional	Ki	=	5200.00	5.28	-22	7	Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)	ChEMBL	231.0	3	4	3	-0.43	NC(C(=O)O)c1ccc(P(=O)(O)O)cc1	https://dx.doi.org/10.1021/jm000007r
(R,S)-4-PPG	2073	None	26	Rat	Functional	EC50	=	5200.00	5.28	-26	7	Metabotropic glutamate receptor 4 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells	ChEMBL	231.0	3	4	3	-0.43	NC(C(=O)O)c1ccc(P(=O)(O)O)cc1	https://dx.doi.org/10.1021/jm030967o
(S)-3,4-DCPG	2079	None	36	Human	Functional	pEC50	None	-	5.10	-117	8	Unclassified	Guide to Pharmacology	239.0	4	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(C(=O)O)c1	https://pubmed.ncbi.nlm.nih.gov/11166323
(S)-3,4-DCPG	2079	None	36	Human	Functional	EC50	=	1960.00	5.71	-117	8	Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method	ChEMBL	239.0	4	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(C(=O)O)c1	https://dx.doi.org/10.1021/acs.jmedchem.7b01438
(S)-3,4-DCPG	2079	None	36	Human	Functional	EC50	=	3200.00	5.50	-117	8	Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium accumulation by Fluo-4 AM dye based fluorescence assay	ChEMBL	239.0	4	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(C(=O)O)c1	https://dx.doi.org/10.1021/acs.jmedchem.7b01438
(S)-3,4-DCPG	2079	None	36	Rat	Functional	EC50	=	8800.00	5.06	-281	8	Metabotropic glutamate receptor 4 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells	ChEMBL	239.0	4	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(C(=O)O)c1	https://dx.doi.org/10.1021/jm030967o
(S)-3,4-DCPG	2079	None	36	Rat	Functional	EC50	=	8800.00	5.06	-281	8	Stimulation od [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells	ChEMBL	239.0	4	4	4	0.17	N[C@H](C(=O)O)c1ccc(C(=O)O)c(C(=O)O)c1	https://dx.doi.org/10.1021/jm049092j
ACPT-I	265	None	24	Human	Functional	EC50	=	1700.00	5.77	1	7	Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method	ChEMBL	217.1	3	4	4	-1.04	N[C@@]1(C(=O)O)C[C@H](C(=O)O)[C@H](C(=O)O)C1	https://dx.doi.org/10.1021/acs.jmedchem.7b01438
ACPT-I	265	None	24	Human	Functional	EC50	=	7200.00	5.14	1	7	Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation	ChEMBL	217.1	3	4	4	-1.04	N[C@@]1(C(=O)O)C[C@H](C(=O)O)[C@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm970207b
ACPT-I	265	None	24	Rat	Functional	pEC50	None	-	5.10	-1	7	Unclassified	Guide to Pharmacology	217.1	3	4	4	-1.04	N[C@@]1(C(=O)O)C[C@H](C(=O)O)[C@H](C(=O)O)C1	https://pubmed.ncbi.nlm.nih.gov/9301676
ACPT-I	265	None	24	Rat	Functional	EC50	=	1740.00	5.76	-1	7	Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting	ChEMBL	217.1	3	4	4	-1.04	N[C@@]1(C(=O)O)C[C@H](C(=O)O)[C@H](C(=O)O)C1	https://dx.doi.org/10.1021/jm901523t
ACPT-I	265	None	24	Rat	Functional	EC50	=	7200.00	5.14	-1	7	Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cells	ChEMBL	217.1	3	4	4	-1.04	N[C@@]1(C(=O)O)C[C@H](C(=O)O)[C@H](C(=O)O)C1	https://dx.doi.org/10.1016/j.bmcl.2006.06.062
ADX88178	300	None	40	Human	Functional	pEC50	=	-	8.50	1	4	Unclassified	Guide to Pharmacology	272.1	3	2	6	2.68	Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1	https://pubmed.ncbi.nlm.nih.gov/22787118
ADX88178	300	None	40	Human	Functional	EC50	=	52.00	7.28	1	4	Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization incubated for 142 secs followed by glutamate addition measured after 120 secs by Fluo4-AM dye based fluorescence assay	ChEMBL	272.1	3	2	6	2.68	Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1	https://dx.doi.org/10.1021/acsmedchemlett.7b00317
ADX88178	300	None	40	Rat	Functional	pEC50	=	-	8.04	-1	4	Unclassified	Guide to Pharmacology	272.1	3	2	6	2.68	Cc1ccnc(Nc2nc(-c3cn[nH]c3)c(C)s2)n1	https://pubmed.ncbi.nlm.nih.gov/22787118

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Ligand source activities (1 row/activity)