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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

CHEMBL1162148	10336	None	22	Human	Binding	IC50	=	5200.00	5.28	-	1	Antagonist activity at P2Y6R (unknown origin)	ChEMBL	453.9	6	2	8	3.82	O=S(=O)(O)c1cc(N=C=S)ccc1/C=C/c1ccc(N=C=S)cc1S(=O)(=O)O	https://dx.doi.org/10.1021/acs.jmedchem.3c00210
CHEMBL2113161	79087	None	0	Human	Binding	EC50	=	230.00	6.64	-	1	Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor	ChEMBL	398.0	6	5	8	-1.14	O=c1ccn([C@@]23C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)O)[C@@H]2C3)c(=O)[nH]1	https://dx.doi.org/10.1021/jm050911p
CHEMBL3261379	110981	None	0	Human	Binding	EC50	=	332.00	6.48	-	3	Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells by functional assay	ChEMBL	923.1	19	10	22	-2.08	O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cc/c(=N/OCCCc5ccccc5)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1	https://dx.doi.org/10.1021/jm500367e
CHEMBL4854398	185101	None	7	Mouse	Binding	IC50	=	20200.00	4.70	-	2	Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	322.9	1	0	3	3.39	O=[N+]([O-])C1=Cc2cc(Br)ccc2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL4870366	186112	None	0	Human	Binding	IC50	=	3970.00	5.40	-	1	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	403.1	2	0	5	3.81	COC(=O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL4875858	186504	None	3	Human	Binding	IC50	=	4000.00	5.40	-	4	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	370.9	1	0	3	3.23	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL4875858	186504	None	3	Mouse	Binding	IC50	=	28700.00	4.54	-	4	Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	370.9	1	0	3	3.23	O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL4877204	186598	None	0	Human	Binding	IC50	=	155.00	6.81	-	1	Antagonist activity at P2Y6R (unknown origin)	ChEMBL	458.0	8	4	6	4.82	S=C=Nc1ccc(NC(=S)NCCCNC(=S)Nc2ccc(N=C=S)cc2)cc1	https://dx.doi.org/10.1021/acs.jmedchem.3c00210
CHEMBL4877977	186654	None	0	Mouse	Binding	IC50	=	4940.00	5.31	-	2	Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	383.1	4	0	3	5.03	CC[Si](C#Cc1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2)(CC)CC	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5267428	193638	None	0	Human	Binding	IC50	=	5360.00	5.27	-	1	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	361.1	1	1	4	3.73	O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(O)cc3)ccc2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5274126	193905	None	0	Mouse	Binding	EC50	=	100.00	7.00	-	1	Agonist activity at P2Y6R in mouse adipose tissue	ChEMBL	443.0	7	6	10	-2.07	CO/N=c1\ccn([C@]23C[C@H]2[C@@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c(=O)[nH]1	https://dx.doi.org/10.1039/D1MD00167A
CHEMBL5274312	193917	None	0	Human	Binding	IC50	=	461.00	6.34	-	7	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	383.1	4	0	3	5.03	CC[Si](C#Cc1cccc2c1OC(C(F)(F)F)C([N+](=O)[O-])=C2)(CC)CC	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5274312	193917	None	0	Mouse	Binding	IC50	=	6150.00	5.21	-	7	Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	383.1	4	0	3	5.03	CC[Si](C#Cc1cccc2c1OC(C(F)(F)F)C([N+](=O)[O-])=C2)(CC)CC	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5277295	194039	None	0	Human	Binding	IC50	=	3690.00	5.43	-	2	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	279.0	1	0	3	3.28	O=[N+]([O-])C1=Cc2cccc(Cl)c2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5277295	194039	None	0	Mouse	Binding	IC50	=	15200.00	4.82	-	2	Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	279.0	1	0	3	3.28	O=[N+]([O-])C1=Cc2cccc(Cl)c2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5278019	194072	None	0	Human	Binding	IC50	=	4770.00	5.32	-	1	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	383.1	4	0	3	5.03	CC[Si](C#Cc1cccc2c1C=C([N+](=O)[O-])C(C(F)(F)F)O2)(CC)CC	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5279172	194124	None	0	Human	Binding	IC50	=	5350.00	5.27	-	1	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	379.0	1	0	3	4.68	O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(Cl)cc3)ccc2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5279730	194146	None	0	Human	Binding	IC50	=	1790.00	5.75	-	4	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	279.0	1	0	3	3.28	O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5279730	194146	None	0	Mouse	Binding	IC50	=	30800.00	4.51	-	4	Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	279.0	1	0	3	3.28	O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981
CHEMBL5280754	194191	None	0	Human	Binding	IC50	=	2990.00	5.52	-	2	Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay	ChEMBL	281.0	1	0	3	2.91	O=[N+]([O-])C1=Cc2cc(F)cc(F)c2OC1C(F)(F)F	https://dx.doi.org/10.1016/j.bmcl.2022.128981

Showing 1 to 20 of 44 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

2-thio-UDP	89	None	0	Human	Functional	EC50	=	60.00	7.22	-85	2	Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production	ChEMBL	420.0	6	6	10	-1.25	O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=S)[nH]1	https://dx.doi.org/10.1021/jm060485n
2-thio-UDP	89	None	0	Human	Functional	EC50	=	447.00	6.35	-85	2	Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production	ChEMBL	420.0	6	6	10	-1.25	O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=S)[nH]1	https://dx.doi.org/10.1021/jm901432g
2-thioUTP	90	None	3	Human	Functional	EC50	=	1500.00	5.82	-33	3	Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by scintillation proximity assay	ChEMBL	499.9	8	7	12	-1.13	O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=S)[nH]1	https://dx.doi.org/10.1021/jm101591j
2-thioUTP	90	None	3	Human	Functional	EC50	=	1500.00	5.82	-33	3	Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay	ChEMBL	499.9	8	7	12	-1.13	O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=S)[nH]1	https://dx.doi.org/10.1016/j.bmc.2008.05.013
2-thioUTP	90	None	3	Human	Functional	EC50	=	1500.00	5.82	-33	3	Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C	ChEMBL	499.9	8	7	12	-1.13	O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=S)[nH]1	https://dx.doi.org/10.1021/jm060903o
2MeSATP	77	None	13	Human	Functional	EC50	=	100000.00	4.00	-91201	7	The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)	ChEMBL	553.0	9	7	15	-0.91	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://dx.doi.org/10.1021/jm020046y
2MeSATP	77	None	13	Human	Functional	pEC50	None	-	4.00	-91201	7	Unclassified	Guide to Pharmacology	553.0	9	7	15	-0.91	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	https://pubmed.ncbi.nlm.nih.gov/8670200
3-phenacyl-UDP	109	None	9	Human	Functional	pEC50	=	-	7.20	-	1	Unclassified	Guide to Pharmacology	522.0	9	5	12	-1.26	O=C(Cn1c(=O)ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c1=O)c1ccccc1	https://pubmed.ncbi.nlm.nih.gov/17125260
3-phenacyl-UDP	109	None	9	Human	Functional	EC50	=	70.00	7.16	-	1	Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA	ChEMBL	522.0	9	5	12	-1.26	O=C(Cn1c(=O)ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c1=O)c1ccccc1	https://dx.doi.org/10.1021/jm060848j
3-phenacyl-UDP	109	None	9	Human	Functional	EC50	=	70.00	7.16	-	1	Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay	ChEMBL	522.0	9	5	12	-1.26	O=C(Cn1c(=O)ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c1=O)c1ccccc1	https://dx.doi.org/10.1021/jm100287t
5BrUTP	130	None	8	Human	Functional	pEC50	None	-	6.10	1	3	Unclassified	Guide to Pharmacology	561.9	8	7	12	-1.74	O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)cc1Br	https://pubmed.ncbi.nlm.nih.gov/8670200
5BrUTP	130	None	8	Human	Functional	EC50	=	800.00	6.10	1	3	Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay	ChEMBL	561.9	8	7	12	-1.74	O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)cc1Br	https://dx.doi.org/10.1021/jm901450d
5BrUTP	130	None	8	Human	Functional	EC50	=	291.00	6.54	1	3	Agonist activity at human P2Y6 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA	ChEMBL	561.9	8	7	12	-1.74	O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)cc1Br	https://dx.doi.org/10.1021/jm060848j
ADP	288	None	48	Human	Functional	pEC50	None	-	4.50	-1096	7	Unclassified	Guide to Pharmacology	427.0	6	6	12	-1.75	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	https://pubmed.ncbi.nlm.nih.gov/8670200
ADP	288	None	48	Human	Functional	EC50	=	65000.00	4.19	-1096	7	Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production	ChEMBL	427.0	6	6	12	-1.75	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	https://dx.doi.org/10.1021/jm060485n
CHEMBL1083257	6617	None	0	Human	Functional	EC50	=	63.00	7.20	8	3	Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay	ChEMBL	768.1	14	9	21	-4.10	CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cc/c(=N/OC)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1	https://dx.doi.org/10.1021/jm100287t
CHEMBL1162163	10343	None	0	Human	Functional	EC50	=	9750.00	5.01	-3	4	Agonist activity at P2Y6 receptor expressed in human 1321 cells by calcium mobilization assay	ChEMBL	546.1	8	7	12	0.32	O=C(Nc1ccccc1)Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	https://dx.doi.org/10.1021/jm701348d
CHEMBL1162193	10367	None	0	Human	Functional	EC50	=	200.00	6.70	60	2	Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor	ChEMBL	710.0	12	9	19	-4.31	O=c1ccn([C@H]2O[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@H](O)[C@@H]2O)c(=O)[nH]1	https://dx.doi.org/10.1016/s0960-894x(00)00612-0
CHEMBL1162193	10367	None	0	Human	Functional	EC50	=	400.00	6.40	60	2	Agonist activity at P2Y6 receptor expressed in human 1321 cells by calcium mobilization assay	ChEMBL	710.0	12	9	19	-4.31	O=c1ccn([C@H]2O[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@H](O)[C@@H]2O)c(=O)[nH]1	https://dx.doi.org/10.1021/jm701348d
CHEMBL1162202	10376	None	0	Human	Functional	EC50	=	30000.00	4.52	-309	2	Agonist activity at P2Y6 receptor expressed in human 1321 cells by calcium mobilization assay	ChEMBL	844.0	16	8	21	-2.00	CCCC1O[C@@H]2[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@@H]3O[C@H](n4ccc(=O)[nH]c4=O)[C@@H](O)[C@H]3O)O[C@@H](n3ccc(=O)[nH]c3=O)[C@@H]2O1	https://dx.doi.org/10.1021/jm701348d

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Ligand source activities (1 row/activity)