Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 90666794 | 109482 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | 9 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysisAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysis |
ChEMBL | 585 | 10 | 6 | 11 | -0.2 | C#CCCC#Cc1cccc(CO/N=c2/ccn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c(=O)[nH]2)c1 | 10.1039/c3md00132f | ||
| CHEMBL3220051 | 109482 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | 9 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysisAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysis |
ChEMBL | 585 | 10 | 6 | 11 | -0.2 | C#CCCC#Cc1cccc(CO/N=c2/ccn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c(=O)[nH]2)c1 | 10.1039/c3md00132f | ||
| 146015339 | 3922 | None | 21 | Human | Functional | pEC50 | = | 7 | 7.0 | -1 | 7 | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptorAgonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/s0960-894x(00)00612-0 | ||
| 1749 | 3922 | None | 21 | Human | Functional | pEC50 | = | 7 | 7.0 | -1 | 7 | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptorAgonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/s0960-894x(00)00612-0 | ||
| 6031 | 3922 | None | 21 | Human | Functional | pEC50 | = | 7 | 7.0 | -1 | 7 | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptorAgonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/s0960-894x(00)00612-0 | ||
| CHEMBL130266 | 3922 | None | 21 | Human | Functional | pEC50 | = | 7 | 7.0 | -1 | 7 | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptorAgonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/s0960-894x(00)00612-0 | ||
| DB03435 | 3922 | None | 21 | Human | Functional | pEC50 | = | 7 | 7.0 | -1 | 7 | Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptorAgonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/s0960-894x(00)00612-0 | ||
| 10432343 | 201835 | None | 4 | Human | Functional | pEC50 | = | 5 | 5.0 | -5 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as concentration required to 50% maximal response of compound 3 at 10 uM by fura2/AM assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as concentration required to 50% maximal response of compound 3 at 10 uM by fura2/AM assay |
ChEMBL | 422 | 6 | 6 | 10 | -2.5 | O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)cc1F | 10.1021/jm901450d | ||
| CHEMBL590981 | 201835 | None | 4 | Human | Functional | pEC50 | = | 5 | 5.0 | -5 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as concentration required to 50% maximal response of compound 3 at 10 uM by fura2/AM assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as concentration required to 50% maximal response of compound 3 at 10 uM by fura2/AM assay |
ChEMBL | 422 | 6 | 6 | 10 | -2.5 | O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)cc1F | 10.1021/jm901450d | ||
| 1711 | 77 | None | 13 | Human | Functional | pEC50 | = | 4 | 4.0 | -91201 | 7 | The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6) |
ChEMBL | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 10.1021/jm020046y | ||
| 5310983 | 77 | None | 13 | Human | Functional | pEC50 | = | 4 | 4.0 | -91201 | 7 | The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6) |
ChEMBL | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 10.1021/jm020046y | ||
| CHEMBL336208 | 77 | None | 13 | Human | Functional | pEC50 | = | 4 | 4.0 | -91201 | 7 | The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6) |
ChEMBL | 553 | 9 | 7 | 15 | -0.9 | CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O | 10.1021/jm020046y | ||
| 135528590 | 188867 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -7 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 813 | 14 | 10 | 22 | -3.0 | Nc1nc(=O)c2ncn([C@H]3C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](n5ccc(=O)[nH]c5=O)[C@H](O)[C@@H]4O)O3)c2[nH]1 | 10.1016/j.bmc.2008.05.013 | ||
| CHEMBL505403 | 188867 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -7 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 813 | 14 | 10 | 22 | -3.0 | Nc1nc(=O)c2ncn([C@H]3C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](n5ccc(=O)[nH]c5=O)[C@H](O)[C@@H]4O)O3)c2[nH]1 | 10.1016/j.bmc.2008.05.013 | ||
| 155525627 | 171163 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodAgonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader method |
ChEMBL | 480 | 6 | 6 | 9 | -1.7 | O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)cc1Br | 10.1016/j.bmcl.2021.128137 | ||
| CHEMBL4457058 | 171163 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodAgonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader method |
ChEMBL | 480 | 6 | 6 | 9 | -1.7 | O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)cc1Br | 10.1016/j.bmcl.2021.128137 | ||
| CHEMBL4848216 | 171163 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodAgonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader method |
ChEMBL | 480 | 6 | 6 | 9 | -1.7 | O=c1[nH]c(=O)n([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)cc1Br | 10.1016/j.bmcl.2021.128137 | ||
| 44627589 | 14174 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate productionAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production |
ChEMBL | 434 | 7 | 5 | 11 | -0.6 | COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(=S)[nH]c2=O)[C@H](O)[C@@H]1O | 10.1021/jm901432g | ||
| CHEMBL1198606 | 14174 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate productionAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production |
ChEMBL | 434 | 7 | 5 | 11 | -0.6 | COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(=S)[nH]c2=O)[C@H](O)[C@@H]1O | 10.1021/jm901432g | ||
| CHEMBL608851 | 14174 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate productionAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells coexpressing phospholipase C-activating Gq protein assessed as [3H]inositol phosphate production |
ChEMBL | 434 | 7 | 5 | 11 | -0.6 | COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(=S)[nH]c2=O)[C@H](O)[C@@H]1O | 10.1021/jm901432g | ||
| 24857827 | 189155 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -13 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 789 | 14 | 9 | 21 | -1.5 | Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=S)[C@H](O)[C@@H]3O)O2)c(=O)n1 | 10.1016/j.bmc.2008.05.013 | ||
| CHEMBL509434 | 189155 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -13 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 789 | 14 | 9 | 21 | -1.5 | Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=S)[C@H](O)[C@@H]3O)O2)c(=O)n1 | 10.1016/j.bmc.2008.05.013 | ||
| 155537270 | 172383 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodAgonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader method |
ChEMBL | 521 | 9 | 6 | 10 | -0.5 | Cc1cn([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]/c1=N/OCc1ccccc1 | 10.1016/j.bmcl.2021.128137 | ||
| CHEMBL4474742 | 172383 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodAgonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader method |
ChEMBL | 521 | 9 | 6 | 10 | -0.5 | Cc1cn([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]/c1=N/OCc1ccccc1 | 10.1016/j.bmcl.2021.128137 | ||
| CHEMBL4875403 | 172383 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader methodAgonist activity at human P2Y6R expressed in 1321N1 cells assessed as calcium mobilization measured by microplate reader method |
ChEMBL | 521 | 9 | 6 | 10 | -0.5 | Cc1cn([C@@H]2O[C@H](COP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]/c1=N/OCc1ccccc1 | 10.1016/j.bmcl.2021.128137 | ||
| 16082719 | 14269 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionAgonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production |
ChEMBL | 492 | 10 | 6 | 12 | -1.3 | O=C(O)CCSc1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)n1 | 10.1021/jm060485n | ||
| CHEMBL1161876 | 14269 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionAgonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production |
ChEMBL | 492 | 10 | 6 | 12 | -1.3 | O=C(O)CCSc1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)n1 | 10.1021/jm060485n | ||
| CHEMBL1199697 | 14269 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | - | 1 | Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionAgonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production |
ChEMBL | 492 | 10 | 6 | 12 | -1.3 | O=C(O)CCSc1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)n1 | 10.1021/jm060485n | ||
| 70693210 | 77461 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based fluorescence spectrophotometryAgonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based fluorescence spectrophotometry |
ChEMBL | 510 | 9 | 6 | 13 | -2.9 | B[P@@](=O)(OC[C@H]1O[C@@H](n2cc(OC)c(=O)[nH]c2=O)[C@H](O)[C@@H]1O)OP(=O)(O)OP(=O)(O)O | 10.1016/j.bmc.2012.07.042 | ||
| CHEMBL2086763 | 77461 | None | 0 | Human | Functional | pEC50 | = | 5.0 | 5.0 | - | 1 | Agonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based fluorescence spectrophotometryAgonist activity at human GFP-tagged P2Y6 receptor expressed in human 1321N1 cells assessed as intracellular calcium mobilization by fura2/AM-based fluorescence spectrophotometry |
ChEMBL | 510 | 9 | 6 | 13 | -2.9 | B[P@@](=O)(OC[C@H]1O[C@@H](n2cc(OC)c(=O)[nH]c2=O)[C@H](O)[C@@H]1O)OP(=O)(O)OP(=O)(O)O | 10.1016/j.bmc.2012.07.042 | ||
| 148197 | 1438 | None | 20 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -21 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 790 | 14 | 10 | 21 | -4.2 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.013 | ||
| 148197.0 | 1438 | None | 20 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -21 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 790 | 14 | 10 | 21 | -4.2 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.013 | ||
| 1736 | 1438 | None | 20 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -21 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 790 | 14 | 10 | 21 | -4.2 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.013 | ||
| 4900 | 1438 | None | 20 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -21 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 790 | 14 | 10 | 21 | -4.2 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.013 | ||
| CHEMBL221326 | 1438 | None | 20 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -21 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 790 | 14 | 10 | 21 | -4.2 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.013 | ||
| DB15919 | 1438 | None | 20 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -21 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay |
ChEMBL | 790 | 14 | 10 | 21 | -4.2 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(OP(=O)(OC[C@H]2O[C@H]([C@@H]([C@@H]2O)O)n2ccc(=O)[nH]c2=O)O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1016/j.bmc.2008.05.013 | ||
| 53309244 | 62937 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -6 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by scintillation proximity assayAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by scintillation proximity assay |
ChEMBL | 726 | 13 | 11 | 20 | -4.6 | O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm101591j | ||
| CHEMBL1784885 | 62937 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -6 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by scintillation proximity assayAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by scintillation proximity assay |
ChEMBL | 726 | 13 | 11 | 20 | -4.6 | O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm101591j | ||
| CHEMBL2029006 | 211603 | None | 0 | Rat | Functional | pEC50 | = | 4.9 | 4.9 | -25 | 2 | Agonist activity at rat P2Y purinoceptor 6 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetryAgonist activity at rat P2Y purinoceptor 6 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry |
ChEMBL | None | None | None | BP(=O)(OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H]1O)OP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O.CCCCN(CCCC)CCCC.CCCCN(CCCC)CCCC.CCCCN(CCCC)CCCC.CCCCN(CCCC)CCCC | 10.1021/jm2013198 | ||||
| 46830491 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLCAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLC |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1039/C7MD00397H | ||
| CHEMBL1083256 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLCAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLC |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1039/C7MD00397H | ||
| CHEMBL1198754 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLCAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLC |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1039/C7MD00397H | ||
| CHEMBL4279296 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLCAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as induction of PLC |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1039/C7MD00397H | ||
| 46830491 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assayAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm100287t | ||
| CHEMBL1083256 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assayAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm100287t | ||
| CHEMBL1198754 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assayAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm100287t | ||
| CHEMBL4279296 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assayAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation proximity assay |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm100287t | ||
| 46830491 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysisAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysis |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1039/c3md00132f | ||
| CHEMBL1083256 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysisAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysis |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1039/c3md00132f | ||
| CHEMBL1198754 | 14194 | None | 3 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 1 | 3 | Agonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysisAgonist activity at human recombinant P2Y6 receptor expressed in human 1321N1 cells using [3H]inositol as substrate assessed as [3H]inositol phosphate formation after 30 mins by liquid scintillation counting analysis |
ChEMBL | 739 | 13 | 9 | 20 | -4.2 | CO/N=c1/ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1039/c3md00132f | ||
Showing 1 to 50 of 1,025 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 171357186 | 193905 | None | 0 | Mouse | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at P2Y6R in mouse adipose tissueAgonist activity at P2Y6R in mouse adipose tissue |
ChEMBL | 443 | 7 | 6 | 10 | -2.1 | CO/N=c1\ccn([C@]23C[C@H]2[C@@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c(=O)[nH]1 | 10.1039/D1MD00167A | ||
| CHEMBL5274126 | 193905 | None | 0 | Mouse | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Agonist activity at P2Y6R in mouse adipose tissueAgonist activity at P2Y6R in mouse adipose tissue |
ChEMBL | 443 | 7 | 6 | 10 | -2.1 | CO/N=c1\ccn([C@]23C[C@H]2[C@@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c(=O)[nH]1 | 10.1039/D1MD00167A | ||
| 145729 | 210089 | None | 8 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 388 | 6 | 5 | 9 | -1.6 | O=c1ccn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]1 | 10.1021/jm050911p | ||
| CHEMBL9519 | 210089 | None | 8 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 388 | 6 | 5 | 9 | -1.6 | O=c1ccn([C@H]2C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]1 | 10.1021/jm050911p | ||
| 11494976 | 79087 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 398 | 6 | 5 | 8 | -1.1 | O=c1ccn([C@@]23C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)O)[C@@H]2C3)c(=O)[nH]1 | 10.1021/jm050911p | ||
| CHEMBL2113161 | 79087 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 398 | 6 | 5 | 8 | -1.1 | O=c1ccn([C@@]23C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)O)[C@@H]2C3)c(=O)[nH]1 | 10.1021/jm050911p | ||
| 146015339 | 3922 | None | 21 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at P2Y6 (unknown origin)Antagonist activity at P2Y6 (unknown origin) |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/acs.jmedchem.5b01972 | ||
| 1749 | 3922 | None | 21 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at P2Y6 (unknown origin)Antagonist activity at P2Y6 (unknown origin) |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/acs.jmedchem.5b01972 | ||
| 6031 | 3922 | None | 21 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at P2Y6 (unknown origin)Antagonist activity at P2Y6 (unknown origin) |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL130266 | 3922 | None | 21 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at P2Y6 (unknown origin)Antagonist activity at P2Y6 (unknown origin) |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/acs.jmedchem.5b01972 | ||
| DB03435 | 3922 | None | 21 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Antagonist activity at P2Y6 (unknown origin)Antagonist activity at P2Y6 (unknown origin) |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/acs.jmedchem.5b01972 | ||
| 90656231 | 110981 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells by functional assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells by functional assay |
ChEMBL | 923 | 19 | 10 | 22 | -2.1 | O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cc/c(=N/OCCCc5ccccc5)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm500367e | ||
| CHEMBL3261379 | 110981 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells by functional assayAgonist activity at human P2Y6 receptor expressed in human 1321N1 cells by functional assay |
ChEMBL | 923 | 19 | 10 | 22 | -2.1 | O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cc/c(=N/OCCCc5ccccc5)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1 | 10.1021/jm500367e | ||
| 146015339 | 3922 | None | 21 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/jm050911p | ||
| 1749 | 3922 | None | 21 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/jm050911p | ||
| 6031 | 3922 | None | 21 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/jm050911p | ||
| CHEMBL130266 | 3922 | None | 21 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/jm050911p | ||
| DB03435 | 3922 | None | 21 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | Stimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptorStimulation of phospholipase C in 1321N1 astrocytoma cells transfected with human P2Y6 receptor |
ChEMBL | 404 | 6 | 6 | 10 | -2.6 | O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O | 10.1021/jm050911p | ||
| 11266452 | 2651 | None | 7 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Antagonist activity at human P2Y6Antagonist activity at human P2Y6 |
ChEMBL | 296 | 5 | 0 | 4 | 4.9 | S=C=Nc1ccc(cc1)CCc1ccc(cc1)N=C=S | 10.1021/acs.jmedchem.5b01972 | ||
| 1752 | 2651 | None | 7 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Antagonist activity at human P2Y6Antagonist activity at human P2Y6 |
ChEMBL | 296 | 5 | 0 | 4 | 4.9 | S=C=Nc1ccc(cc1)CCc1ccc(cc1)N=C=S | 10.1021/acs.jmedchem.5b01972 | ||
| CHEMBL5272895 | 2651 | None | 7 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | Antagonist activity at human P2Y6Antagonist activity at human P2Y6 |
ChEMBL | 296 | 5 | 0 | 4 | 4.9 | S=C=Nc1ccc(cc1)CCc1ccc(cc1)N=C=S | 10.1021/acs.jmedchem.5b01972 | ||
| 171347530 | 194492 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 263 | 1 | 0 | 3 | 2.8 | O=[N+]([O-])C1=Cc2cc(F)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5287483 | 194492 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 263 | 1 | 0 | 3 | 2.8 | O=[N+]([O-])C1=Cc2cc(F)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 171352167 | 194296 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2c(I)cccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5283093 | 194296 | None | 0 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2c(I)cccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 171346974 | 194476 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 341 | 1 | 0 | 3 | 3.5 | O=[N+]([O-])C1=Cc2cc(F)cc(Br)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5286996 | 194476 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 341 | 1 | 0 | 3 | 3.5 | O=[N+]([O-])C1=Cc2cc(F)cc(Br)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 171353283 | 194039 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2cccc(Cl)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5277295 | 194039 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2cccc(Cl)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 164626586 | 186598 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at P2Y6R (unknown origin)Antagonist activity at P2Y6R (unknown origin) |
ChEMBL | 458 | 8 | 4 | 6 | 4.8 | S=C=Nc1ccc(NC(=S)NCCCNC(=S)Nc2ccc(N=C=S)cc2)cc1 | 10.1021/acs.jmedchem.3c00210 | ||
| CHEMBL4877204 | 186598 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | Antagonist activity at P2Y6R (unknown origin)Antagonist activity at P2Y6R (unknown origin) |
ChEMBL | 458 | 8 | 4 | 6 | 4.8 | S=C=Nc1ccc(NC(=S)NCCCNC(=S)Nc2ccc(N=C=S)cc2)cc1 | 10.1021/acs.jmedchem.3c00210 | ||
| 171354944 | 194197 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2c(Cl)cccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5280900 | 194197 | None | 0 | Human | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2c(Cl)cccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 171357174 | 194291 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2cccc(I)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5283029 | 194291 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2cccc(I)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 171357072 | 194191 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 281 | 1 | 0 | 3 | 2.9 | O=[N+]([O-])C1=Cc2cc(F)cc(F)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5280754 | 194191 | None | 0 | Mouse | Binding | pIC50 | = | 4.8 | 4.8 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 281 | 1 | 0 | 3 | 2.9 | O=[N+]([O-])C1=Cc2cc(F)cc(F)c2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 164606105 | 194146 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 2 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5279730 | 194146 | None | 0 | Human | Binding | pIC50 | = | 5.8 | 5.8 | - | 2 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 279 | 1 | 0 | 3 | 3.3 | O=[N+]([O-])C1=Cc2cc(Cl)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 171347340 | 194310 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 375 | 2 | 1 | 4 | 3.5 | O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(CO)cc3)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5283362 | 194310 | None | 0 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 1 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 375 | 2 | 1 | 4 | 3.5 | O=[N+]([O-])C1=Cc2cc(C#Cc3ccc(CO)cc3)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 11681366 | 185101 | None | 7 | Mouse | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 323 | 1 | 0 | 3 | 3.4 | O=[N+]([O-])C1=Cc2cc(Br)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL4854398 | 185101 | None | 7 | Mouse | Binding | pIC50 | = | 4.7 | 4.7 | - | 0 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 323 | 1 | 0 | 3 | 3.4 | O=[N+]([O-])C1=Cc2cc(Br)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 171348380 | 194484 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 329 | 3 | 0 | 5 | 2.8 | COC(=O)/C=C/c1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL5287190 | 194484 | None | 0 | Human | Binding | pIC50 | = | 5.6 | 5.6 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 329 | 3 | 0 | 5 | 2.8 | COC(=O)/C=C/c1ccc2c(c1)C=C([N+](=O)[O-])C(C(F)(F)F)O2 | 10.1016/j.bmcl.2022.128981 | ||
| 163198500 | 186504 | None | 3 | Mouse | Binding | pIC50 | = | 4.5 | 4.5 | - | 2 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL4875858 | 186504 | None | 3 | Mouse | Binding | pIC50 | = | 4.5 | 4.5 | - | 2 | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assayAntagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay |
ChEMBL | 371 | 1 | 0 | 3 | 3.2 | O=[N+]([O-])C1=Cc2cc(I)ccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 11452 | 3819 | None | 13 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization incubated for 5 mins followed by agonist stimulation by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization incubated for 5 mins followed by agonist stimulation by FLIPR assay |
ChEMBL | 245 | 1 | 0 | 3 | 2.6 | [O-][N+](=O)C1=Cc2ccccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| 16762479 | 3819 | None | 13 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization incubated for 5 mins followed by agonist stimulation by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization incubated for 5 mins followed by agonist stimulation by FLIPR assay |
ChEMBL | 245 | 1 | 0 | 3 | 2.6 | [O-][N+](=O)C1=Cc2ccccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
| CHEMBL4876210 | 3819 | None | 13 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization incubated for 5 mins followed by agonist stimulation by FLIPR assayAntagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization incubated for 5 mins followed by agonist stimulation by FLIPR assay |
ChEMBL | 245 | 1 | 0 | 3 | 2.6 | [O-][N+](=O)C1=Cc2ccccc2OC1C(F)(F)F | 10.1016/j.bmcl.2022.128981 | ||
Showing 1 to 50 of 98 entries