Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI




Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Affinity)
# tested GPCRs
(Affinity)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
259210 148721 22 None - 0 Bovine 4.4 pEC50 = 4.4 Binding
Binding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopyBinding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopy
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q
CHEMBL387152 148721 22 None - 0 Bovine 4.4 pEC50 = 4.4 Binding
Binding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopyBinding affinity to photoactivated rhodopsin in bovine retinal rod outer-segment membranes assessed as induction of extra receptor MII state stabilization by UV/visible difference spectroscopy
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q
259210 148721 22 None - 0 Bovine 4.8 pIC50 = 4.8 Binding
Inhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assayInhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assay
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q
CHEMBL387152 148721 22 None - 0 Bovine 4.8 pIC50 = 4.8 Binding
Inhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assayInhibition of bovine retinal rod outer-segment photoactivated rhodopsin-transducer interaction by transducer release assay
ChEMBL 548 5 0 5 5.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c1ccc(Br)cc1 10.1021/jm800326q