Ligand source activities (1 row/activity)
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 6433 | 10629 | 0 | None | -10 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 563 | 10 | 4 | 9 | 2.2 | COc1ccc(cc1)Cn1c(NCCNC(=N)NC(=O)c2ccc(cc2)F)nc(=O)n(c1=O)Cc1ccc(cc1)F | 21421710 | ||
| 73755221 | 10629 | 0 | None | -10 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | Guide to Pharmacology | 563 | 10 | 4 | 9 | 2.2 | COc1ccc(cc1)Cn1c(NCCNC(=N)NC(=O)c2ccc(cc2)F)nc(=O)n(c1=O)Cc1ccc(cc1)F | 21421710 | ||
| 1866 | 9952 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 12054613 | ||||
| 1866 | 9952 | 0 | None | 1 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | None | None | None | None | 15772293 | ||||
| 16122905 | 9909 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 438 | 7 | 0 | 5 | 3.7 | CC(CN(C(=O)C1OCCN(C1)Cc1ccccc1)Cc1ccc2c(c1)OCCCO2)C | 22431614 | ||
| 6066 | 9909 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | Guide to Pharmacology | 438 | 7 | 0 | 5 | 3.7 | CC(CN(C(=O)C1OCCN(C1)Cc1ccccc1)Cc1ccc2c(c1)OCCCO2)C | 22431614 | ||
| 1867 | 9953 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 12054613 | ||||
| 1867 | 9953 | 0 | None | -1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | None | None | None | None | 15772293 | ||||
| 1865 | 9321 | 0 | None | 6 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | None | None | None | None | 12054613 | ||||
| 1868 | 9955 | 0 | None | -31 | 2 | Human | 6.0 | pIC50 | > | 6 | Functional | Guide to Pharmacology | None | None | None | None | 15772293 | ||||
| Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
| 11951384 | 10628 | 0 | None | -74 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 10 | 3 | 8 | 0.8 | CCc1ccc(cc1)Cn1c(=O)nc(n(c1=O)Cc1ccc(cc1)OC)NCCN=C(N)N | 10.1021/jm800854e | ||
| 6064 | 10628 | 0 | None | -74 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 10 | 3 | 8 | 0.8 | CCc1ccc(cc1)Cn1c(=O)nc(n(c1=O)Cc1ccc(cc1)OC)NCCN=C(N)N | 10.1021/jm800854e | ||
| CHEMBL457515 | 10628 | 0 | None | -74 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 451 | 10 | 3 | 8 | 0.8 | CCc1ccc(cc1)Cn1c(=O)nc(n(c1=O)Cc1ccc(cc1)OC)NCCN=C(N)N | 10.1021/jm800854e | ||
| 25138121 | 196402 | 0 | None | -53 | 2 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 409 | 9 | 2 | 8 | 1.4 | CCc1ccc(Cn2c(=O)nc(NCCN)n(Cc3ccc(OC)cc3)c2=O)cc1 | 10.1021/jm800854e | ||
| CHEMBL514895 | 196402 | 0 | None | -53 | 2 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 409 | 9 | 2 | 8 | 1.4 | CCc1ccc(Cn2c(=O)nc(NCCN)n(Cc3ccc(OC)cc3)c2=O)cc1 | 10.1021/jm800854e | ||
| 25138122 | 182878 | 0 | None | -15 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 477 | 10 | 3 | 10 | 1.0 | CCc1ccc(Cn2c(=O)nc(NCCNC3=NCCN3)n(Cc3ccc(OC)cc3)c2=O)cc1 | 10.1021/jm800854e | ||
| CHEMBL459142 | 182878 | 0 | None | -15 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 477 | 10 | 3 | 10 | 1.0 | CCc1ccc(Cn2c(=O)nc(NCCNC3=NCCN3)n(Cc3ccc(OC)cc3)c2=O)cc1 | 10.1021/jm800854e | ||
| 11951384 | 10628 | 0 | None | -74 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 451 | 10 | 3 | 8 | 0.8 | CCc1ccc(cc1)Cn1c(=O)nc(n(c1=O)Cc1ccc(cc1)OC)NCCN=C(N)N | 19006379 | ||
| 6064 | 10628 | 0 | None | -74 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 451 | 10 | 3 | 8 | 0.8 | CCc1ccc(cc1)Cn1c(=O)nc(n(c1=O)Cc1ccc(cc1)OC)NCCN=C(N)N | 19006379 | ||
| CHEMBL457515 | 10628 | 0 | None | -74 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | Guide to Pharmacology | 451 | 10 | 3 | 8 | 0.8 | CCc1ccc(cc1)Cn1c(=O)nc(n(c1=O)Cc1ccc(cc1)OC)NCCN=C(N)N | 19006379 | ||