Ligand source activities (1 row/activity)
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
1481 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
3749 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
589 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
6908 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
CHEMBL1513 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
DB01029 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
40466887 | 212654 | 66 | None | - | 1 | Human | 5.4 | pAC50 | = | 5.4 | Functional | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
5362124 | 212654 | 66 | None | - | 1 | Human | 5.4 | pAC50 | = | 5.4 | Functional | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
CHEMBL838 | 212654 | 66 | None | - | 1 | Human | 5.4 | pAC50 | = | 5.4 | Functional | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
1610 | 9126 | 95 | None | -954 | 11 | Human | 6.3 | pAC50 | = | 6.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
3941 | 9126 | 95 | None | -954 | 11 | Human | 6.3 | pAC50 | = | 6.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
3961 | 9126 | 95 | None | -954 | 11 | Human | 6.3 | pAC50 | = | 6.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
590 | 9126 | 95 | None | -954 | 11 | Human | 6.3 | pAC50 | = | 6.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
CHEMBL191 | 9126 | 95 | None | -954 | 11 | Human | 6.3 | pAC50 | = | 6.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
DB00678 | 9126 | 95 | None | -954 | 11 | Human | 6.3 | pAC50 | = | 6.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
158781 | 50940 | 98 | None | -95499 | 3 | Human | 4.3 | pAC50 | = | 4.3 | Functional | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | ||
CHEMBL1516 | 50940 | 98 | None | -95499 | 3 | Human | 4.3 | pAC50 | = | 4.3 | Functional | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | ||
1610 | 9126 | 95 | None | -954 | 11 | Human | 4.2 | pAC50 | = | 4.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
3941 | 9126 | 95 | None | -954 | 11 | Human | 4.2 | pAC50 | = | 4.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
3961 | 9126 | 95 | None | -954 | 11 | Human | 4.2 | pAC50 | = | 4.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
590 | 9126 | 95 | None | -954 | 11 | Human | 4.2 | pAC50 | = | 4.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
CHEMBL191 | 9126 | 95 | None | -954 | 11 | Human | 4.2 | pAC50 | = | 4.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
DB00678 | 9126 | 95 | None | -954 | 11 | Human | 4.2 | pAC50 | = | 4.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
1610 | 9126 | 95 | None | -954 | 11 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
3941 | 9126 | 95 | None | -954 | 11 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
3961 | 9126 | 95 | None | -954 | 11 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
590 | 9126 | 95 | None | -954 | 11 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
CHEMBL191 | 9126 | 95 | None | -954 | 11 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
DB00678 | 9126 | 95 | None | -954 | 11 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | ||
130881 | 9695 | 108 | None | -23442 | 3 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
1985 | 9695 | 108 | None | -23442 | 3 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
591 | 9695 | 108 | None | -23442 | 3 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
CHEMBL1200692 | 9695 | 108 | None | -23442 | 3 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
DB00275 | 9695 | 108 | None | -23442 | 3 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
nan | 9695 | 108 | None | -23442 | 3 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | ||
40466887 | 212654 | 66 | None | - | 1 | Human | 5.1 | pAC50 | = | 5.1 | Functional | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
5362124 | 212654 | 66 | None | - | 1 | Human | 5.1 | pAC50 | = | 5.1 | Functional | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
CHEMBL838 | 212654 | 66 | None | - | 1 | Human | 5.1 | pAC50 | = | 5.1 | Functional | ChEMBL | 424 | 9 | 2 | 5 | 2.6 | CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O | 10.1038/s41467-023-40064-9 | ||
2541 | 7573 | 120 | None | -45708 | 10 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
587 | 7573 | 120 | None | -45708 | 10 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
6907 | 7573 | 120 | None | -45708 | 10 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
CHEMBL1016 | 7573 | 120 | None | -45708 | 10 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
DB00796 | 7573 | 120 | None | -45708 | 10 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
DB13919 | 7573 | 120 | None | -45708 | 10 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | ||
3033 | 36925 | 102 | None | -8709 | 4 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 295 | 4 | 2 | 2 | 4.4 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | 10.1038/s41467-023-40064-9 | ||
CHEMBL1034 | 36925 | 102 | None | -8709 | 4 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 295 | 4 | 2 | 2 | 4.4 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | 10.1038/s41467-023-40064-9 | ||
CHEMBL139 | 36925 | 102 | None | -8709 | 4 | Human | 4.1 | pAC50 | = | 4.1 | Functional | ChEMBL | 295 | 4 | 2 | 2 | 4.4 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | 10.1038/s41467-023-40064-9 | ||
2540 | 11173 | 111 | None | -1380 | 28 | Human | 5.0 | pAC50 | = | 5.0 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | ||
CHEMBL1014 | 11173 | 111 | None | -1380 | 28 | Human | 5.0 | pAC50 | = | 5.0 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | ||
1481 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4.0 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
3749 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4.0 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
589 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4.0 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
6908 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4.0 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
CHEMBL1513 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4.0 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
DB01029 | 8847 | 116 | None | -109647 | 6 | Human | 4.0 | pAC50 | = | 4.0 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | ||
44377942 | 64228 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 530 | 6 | 2 | 5 | 5.9 | O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F | 10.1021/jm1013693 | ||
CHEMBL165572 | 64228 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 530 | 6 | 2 | 5 | 5.9 | O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F | 10.1021/jm1013693 | ||
44355628 | 31678 | 0 | None | -5 | 2 | Rat | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
CHEMBL134567 | 31678 | 0 | None | -5 | 2 | Rat | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
10411653 | 31196 | 0 | None | -208 | 2 | Rat | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
CHEMBL134151 | 31196 | 0 | None | -208 | 2 | Rat | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
10410730 | 31390 | 0 | None | -6 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
CHEMBL134307 | 31390 | 0 | None | -6 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
10048220 | 32961 | 0 | None | -109 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
CHEMBL135704 | 32961 | 0 | None | -109 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
10322995 | 122041 | 0 | None | -134 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
CHEMBL334832 | 122041 | 0 | None | -134 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
10003482 | 172522 | 0 | None | -158 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
CHEMBL424643 | 172522 | 0 | None | -158 | 2 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
10364891 | 33017 | 0 | None | -33 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
CHEMBL135792 | 33017 | 0 | None | -33 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
192345 | 33008 | 6 | None | -12022 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
CHEMBL135775 | 33008 | 6 | None | -12022 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
10393397 | 29571 | 0 | None | -6 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL132807 | 29571 | 0 | None | -6 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
10367704 | 29115 | 0 | None | -25 | 2 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
CHEMBL132408 | 29115 | 0 | None | -25 | 2 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
10094520 | 31530 | 0 | None | -11 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
CHEMBL134433 | 31530 | 0 | None | -11 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
15698118 | 212922 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 537 | 10 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
CHEMBL86067 | 212922 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 537 | 10 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
44355660 | 28329 | 0 | None | -89 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
CHEMBL131676 | 28329 | 0 | None | -89 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
11743704 | 122276 | 0 | None | -3 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
CHEMBL335179 | 122276 | 0 | None | -3 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
10026268 | 123708 | 0 | None | -173 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
CHEMBL338505 | 123708 | 0 | None | -173 | 2 | Rat | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
10322504 | 33155 | 0 | None | -19 | 2 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL135929 | 33155 | 0 | None | -19 | 2 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
10095493 | 32820 | 0 | None | -93 | 2 | Rat | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
CHEMBL135521 | 32820 | 0 | None | -93 | 2 | Rat | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
11754335 | 32075 | 0 | None | -186 | 2 | Rat | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
CHEMBL134901 | 32075 | 0 | None | -186 | 2 | Rat | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
1610 | 9126 | 95 | None | -954 | 11 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | ||
3941 | 9126 | 95 | None | -954 | 11 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | ||
3961 | 9126 | 95 | None | -954 | 11 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | ||
590 | 9126 | 95 | None | -954 | 11 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | ||
CHEMBL191 | 9126 | 95 | None | -954 | 11 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | ||
DB00678 | 9126 | 95 | None | -954 | 11 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm1013693 | ||
44355662 | 33235 | 0 | None | -125 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
CHEMBL135999 | 33235 | 0 | None | -125 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
10411101 | 172444 | 0 | None | -676 | 2 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
CHEMBL424465 | 172444 | 0 | None | -676 | 2 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
19742811 | 64195 | 0 | None | 1 | 3 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
CHEMBL165354 | 64195 | 0 | None | 1 | 3 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
130762 | 105023 | 9 | None | 1 | 6 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm1013693 | ||
CHEMBL274447 | 105023 | 9 | None | 1 | 6 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm1013693 | ||
192567 | 123430 | 6 | None | -223 | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL337007 | 123430 | 6 | None | -223 | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
10366811 | 31598 | 0 | None | -31 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL134491 | 31598 | 0 | None | -31 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
11744592 | 122281 | 0 | None | -33 | 2 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
CHEMBL335228 | 122281 | 0 | None | -33 | 2 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
10409549 | 122756 | 0 | None | -104 | 2 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL335514 | 122756 | 0 | None | -104 | 2 | Rat | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
10027636 | 31366 | 0 | None | -70 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL134286 | 31366 | 0 | None | -70 | 2 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
71455883 | 90539 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1021/jm1013693 | ||
CHEMBL2205685 | 90539 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1021/jm1013693 | ||
10048602 | 32822 | 0 | None | -37 | 2 | Rat | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
CHEMBL135522 | 32822 | 0 | None | -37 | 2 | Rat | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
9914666 | 123448 | 0 | None | -3388 | 2 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
CHEMBL337086 | 123448 | 0 | None | -3388 | 2 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
9846535 | 64289 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 5 | 2 | 4 | 5.4 | O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 | 10.1021/jm1013693 | ||
CHEMBL166143 | 64289 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 427 | 5 | 2 | 4 | 5.4 | O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 | 10.1021/jm1013693 | ||
10326140 | 123429 | 0 | None | -2884 | 2 | Rat | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
CHEMBL337006 | 123429 | 0 | None | -2884 | 2 | Rat | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
10365283 | 32625 | 0 | None | -416 | 2 | Rat | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL135345 | 32625 | 0 | None | -416 | 2 | Rat | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
10393717 | 122877 | 0 | None | -524 | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
CHEMBL335722 | 122877 | 0 | None | -524 | 2 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
10344571 | 123392 | 0 | None | -125 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
CHEMBL336773 | 123392 | 0 | None | -125 | 2 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
10027714 | 122215 | 0 | None | -398 | 2 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
CHEMBL335066 | 122215 | 0 | None | -398 | 2 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
10004112 | 32302 | 0 | None | -93 | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
CHEMBL135089 | 32302 | 0 | None | -93 | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
10344052 | 123385 | 0 | None | -107 | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
CHEMBL336738 | 123385 | 0 | None | -107 | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
10437543 | 33039 | 0 | None | -7 | 2 | Rat | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL135819 | 33039 | 0 | None | -7 | 2 | Rat | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
10414429 | 122775 | 0 | None | -363 | 2 | Rat | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
CHEMBL335535 | 122775 | 0 | None | -363 | 2 | Rat | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
10434876 | 123396 | 0 | None | -7 | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
CHEMBL336808 | 123396 | 0 | None | -7 | 2 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
10026868 | 30631 | 0 | None | -331 | 2 | Rat | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
CHEMBL133653 | 30631 | 0 | None | -331 | 2 | Rat | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
10456041 | 32627 | 0 | None | -186 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
CHEMBL135346 | 32627 | 0 | None | -186 | 2 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
10095589 | 122297 | 0 | None | -851 | 2 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
CHEMBL335289 | 122297 | 0 | None | -851 | 2 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
10345459 | 123548 | 0 | None | -43 | 2 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
CHEMBL337663 | 123548 | 0 | None | -43 | 2 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
10250898 | 125266 | 0 | None | -37 | 2 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
CHEMBL341407 | 125266 | 0 | None | -37 | 2 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
10071193 | 211103 | 0 | None | - | 0 | Rat | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 427 | 7 | 1 | 4 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 | 10.1021/jm9508853 | ||
CHEMBL71485 | 211103 | 0 | None | - | 0 | Rat | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 427 | 7 | 1 | 4 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 | 10.1021/jm9508853 | ||
6918 | 7815 | 35 | None | -7 | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116790 | ||
9804984 | 7815 | 35 | None | -7 | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116790 | ||
CHEMBL189568 | 7815 | 35 | None | -7 | 2 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116790 | ||
6918 | 7815 | 35 | None | -7 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | ||
9804984 | 7815 | 35 | None | -7 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | ||
CHEMBL189568 | 7815 | 35 | None | -7 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | ||
6918 | 7815 | 35 | None | 7 | 2 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | ||
9804984 | 7815 | 35 | None | 7 | 2 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | ||
CHEMBL189568 | 7815 | 35 | None | 7 | 2 | Rat | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 22802221 | ||
1610 | 9126 | 95 | None | -2884 | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
3941 | 9126 | 95 | None | -2884 | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
3961 | 9126 | 95 | None | -2884 | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
590 | 9126 | 95 | None | -2884 | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
CHEMBL191 | 9126 | 95 | None | -2884 | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
DB00678 | 9126 | 95 | None | -2884 | 11 | Rat | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
36736 | 10247 | 0 | None | 2 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
598 | 10247 | 0 | None | 2 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
6324663 | 10247 | 0 | None | 2 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
CHEMBL356431 | 10247 | 0 | None | 2 | 2 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | None | None | None | None | None | ||||
123805 | 7205 | 0 | None | -35 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
46878481 | 7205 | 0 | None | -35 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
5578 | 7205 | 0 | None | -35 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
582 | 7205 | 0 | None | -35 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
CHEMBL3545347 | 7205 | 0 | None | -35 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
DB11720 | 7205 | 0 | None | -35 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
8374 | 9696 | 42 | None | -38 | 3 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
9937291 | 9696 | 42 | None | -38 | 3 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
CHEMBL34124 | 9696 | 42 | None | -38 | 3 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
DB16266 | 9696 | 42 | None | -38 | 3 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
8374 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
8374 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | ||
8374 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | ||
9937291 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
9937291 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | ||
9937291 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | ||
CHEMBL34124 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
CHEMBL34124 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | ||
CHEMBL34124 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | ||
DB16266 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 23489258 | ||
DB16266 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507377 | ||
DB16266 | 9696 | 42 | None | 38 | 3 | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 24507378 | ||
114899 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2314387 | ||
114899 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2590220 | ||
114899 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 8469774 | ||
596 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2314387 | ||
596 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2590220 | ||
596 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 8469774 | ||
CHEMBL1188080 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2314387 | ||
CHEMBL1188080 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 2590220 | ||
CHEMBL1188080 | 9794 | 15 | None | 64 | 2 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | Guide to Pharmacology | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 8469774 | ||
36736 | 10247 | 0 | None | 2 | 2 | Rat | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | None | None | None | None | 2590220 | ||||
598 | 10247 | 0 | None | 2 | 2 | Rat | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | None | None | None | None | 2590220 | ||||
6324663 | 10247 | 0 | None | 2 | 2 | Rat | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | None | None | None | None | 2590220 | ||||
CHEMBL356431 | 10247 | 0 | None | 2 | 2 | Rat | 9.0 | pIC50 | = | 9 | Functional | Guide to Pharmacology | None | None | None | None | 2590220 | ||||
123794 | 7680 | 46 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
3944 | 7680 | 46 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
594 | 7680 | 46 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
CHEMBL1885579 | 7680 | 46 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | None | None | None | None | 21542804 | ||||
6894 | 7206 | 0 | None | 2 | 3 | Human | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 17138938 | ||||
91691124 | 7206 | 0 | None | 2 | 3 | Human | 9.9 | pIC50 | = | 9.9 | Functional | Guide to Pharmacology | None | None | None | None | 17138938 |
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
44348523 | 119956 | 0 | None | - | 0 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL331450 | 119956 | 0 | None | - | 0 | Rat | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
11930 | 7806 | 0 | None | - | 2 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | ||
15780052 | 7806 | 0 | None | - | 2 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL289472 | 7806 | 0 | None | - | 2 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | ||
10033116 | 215015 | 0 | None | - | 0 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL98665 | 215015 | 0 | None | - | 0 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
11765177 | 123786 | 0 | None | - | 0 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338888 | 123786 | 0 | None | - | 0 | Rat | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2016.11.014 | ||||
CHEMBL385433 | 219129 | 2 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmc.2016.03.006 | ||||
10259841 | 22930 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122401 | 22930 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10417195 | 115856 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL321313 | 115856 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10078554 | 123746 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338687 | 123746 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10440174 | 174593 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 767 | 17 | 1 | 9 | 8.0 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL430659 | 174593 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 767 | 17 | 1 | 9 | 8.0 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL385189 | 219122 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccs1)C(=O)O | 10.1021/jm00108a043 | ||||
10078800 | 115968 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL321531 | 115968 | 0 | None | - | 0 | Rat | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
9853391 | 123617 | 1 | None | - | 0 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338027 | 123617 | 1 | None | - | 0 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
9853391 | 123617 | 1 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | ||
CHEMBL338027 | 123617 | 1 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | ||
CHEMBL2391146 | 217191 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmc.2013.03.016 | ||||
10101351 | 175443 | 0 | None | - | 0 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL436396 | 175443 | 0 | None | - | 0 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10259525 | 22391 | 0 | None | - | 0 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL122158 | 22391 | 0 | None | - | 0 | Rat | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10372810 | 112979 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL313868 | 112979 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10078800 | 115968 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL321531 | 115968 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10395335 | 123860 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339256 | 123860 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
10033136 | 22845 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122380 | 22845 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
19430477 | 214910 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 732 | 18 | 1 | 8 | 8.1 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 | 10.1021/jm00015a016 | ||
CHEMBL98047 | 214910 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 732 | 18 | 1 | 8 | 8.1 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 | 10.1021/jm00015a016 | ||
10259468 | 125259 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL341369 | 125259 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10101606 | 22543 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122273 | 22543 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10032988 | 123695 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338434 | 123695 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10440179 | 114176 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL317962 | 114176 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
10078780 | 123694 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338433 | 123694 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10259468 | 125259 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL341369 | 125259 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10259265 | 116820 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL323506 | 116820 | 0 | None | - | 0 | Rat | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10372659 | 124868 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL340632 | 124868 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10327728 | 104898 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL273542 | 104898 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10078554 | 123746 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338687 | 123746 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10033116 | 215015 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL98665 | 215015 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 766 | 17 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
44348523 | 119956 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL331450 | 119956 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10032877 | 22321 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL121907 | 22321 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
183134 | 211623 | 17 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
CHEMBL7550 | 211623 | 17 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
10259525 | 22391 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL122158 | 22391 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10010071 | 124127 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339722 | 124127 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
15292111 | 211524 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74442 | 211524 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL2392353 | 217193 | 6 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2013.01.044 | ||||
10033136 | 22845 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122380 | 22845 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10439837 | 23125 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL122917 | 23125 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10032820 | 124082 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339672 | 124082 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
9853391 | 123617 | 1 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338027 | 123617 | 1 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10101690 | 123639 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338137 | 123639 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10440144 | 123672 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338342 | 123672 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10439715 | 123813 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339040 | 123813 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44314761 | 109631 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL305647 | 109631 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315344 | 111858 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311386 | 111858 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315078 | 211535 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74556 | 211535 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
15780085 | 124928 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL34082 | 124928 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
10440144 | 123672 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338342 | 123672 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10032988 | 123695 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338434 | 123695 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10101351 | 175443 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL436396 | 175443 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44315078 | 211535 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74556 | 211535 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10033126 | 174916 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL433005 | 174916 | 0 | None | - | 0 | Rat | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
10078780 | 123694 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338433 | 123694 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10372451 | 124072 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339605 | 124072 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10462683 | 120059 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331507 | 120059 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44283480 | 107244 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL290768 | 107244 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
10259265 | 116820 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL323506 | 116820 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10259265 | 116820 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL323506 | 116820 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10462933 | 23654 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL125008 | 23654 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
19754068 | 109510 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL304946 | 109510 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
10101606 | 22543 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122273 | 22543 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10101608 | 123807 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL339004 | 123807 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44315282 | 103399 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL263452 | 103399 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | ||
44315351 | 111662 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311160 | 111662 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
9896750 | 10952 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm00015a016 | ||
CHEMBL100119 | 10952 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm00015a016 | ||
10372550 | 171295 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL421478 | 171295 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10439715 | 123813 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339040 | 123813 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
9987414 | 123827 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339113 | 123827 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
11765177 | 123786 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338888 | 123786 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10032851 | 23607 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL124771 | 23607 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44314761 | 109631 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL305647 | 109631 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | ||
9896750 | 10952 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm9504722 | ||
CHEMBL100119 | 10952 | 0 | None | - | 0 | Rat | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 18 | 1 | 9 | 7.5 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 | 10.1021/jm9504722 | ||
10032877 | 22321 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL121907 | 22321 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10009984 | 119957 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331455 | 119957 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | ||
10078475 | 120107 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331632 | 120107 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
9987414 | 123827 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339113 | 123827 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10010164 | 124175 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL339806 | 124175 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
11765560 | 22309 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL121872 | 22309 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44314822 | 109726 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL306362 | 109726 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
9895877 | 60663 | 1 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 653 | 12 | 2 | 8 | 7.1 | CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm9504722 | ||
CHEMBL160494 | 60663 | 1 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 653 | 12 | 2 | 8 | 7.1 | CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm9504722 | ||
10439858 | 23633 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL124903 | 23633 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10259447 | 23700 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | ||
CHEMBL125280 | 23700 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | ||
10010071 | 124127 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339722 | 124127 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
15292111 | 211524 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74442 | 211524 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
19754061 | 109511 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL304947 | 109511 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | ||
10462573 | 123787 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338889 | 123787 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10395335 | 123860 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339256 | 123860 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
44315349 | 67164 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL17487 | 67164 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10394859 | 24201 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL125760 | 24201 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
2583 | 10548 | 118 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | ||
592 | 10548 | 118 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | ||
65999 | 10548 | 118 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | ||
CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | ||
DB00966 | 10548 | 118 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | ||
10373120 | 124379 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL340078 | 124379 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | ||
10394859 | 24201 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL125760 | 24201 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44315351 | 111662 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311160 | 111662 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
15780090 | 107231 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL290669 | 107231 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
10101608 | 123807 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL339004 | 123807 | 0 | None | - | 0 | Rat | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10259841 | 22930 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122401 | 22930 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10372659 | 124868 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL340632 | 124868 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44314822 | 109726 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL306362 | 109726 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10373120 | 124379 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL340078 | 124379 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | ||
44315144 | 103367 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL263191 | 103367 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10032851 | 23607 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL124771 | 23607 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10395076 | 175355 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL435811 | 175355 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
9874508 | 211459 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL73876 | 211459 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
9874508 | 211459 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | ||
CHEMBL73876 | 211459 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | ||
44338708 | 117221 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | ||
CHEMBL324629 | 117221 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | ||
22850667 | 207579 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL60071 | 207579 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
10032820 | 124082 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339672 | 124082 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
10462683 | 120059 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331507 | 120059 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44314823 | 168665 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL415073 | 168665 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL938 | 222686 | 28 | None | -1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | ||||
9809637 | 210631 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL68618 | 210631 | 0 | None | - | 0 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
9830680 | 107419 | 0 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | ||
CHEMBL292150 | 107419 | 0 | None | - | 1 | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | ||
15780094 | 106586 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL285433 | 106586 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL384352 | 219103 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 | 10.1021/jm00065a013 | ||||
9917295 | 109735 | 17 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL306407 | 109735 | 17 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
10417321 | 22390 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122157 | 22390 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10439819 | 176668 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL444065 | 176668 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
15292113 | 102808 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL259843 | 102808 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10078800 | 115968 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL321531 | 115968 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10485034 | 113963 | 1 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL316503 | 113963 | 1 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
15292113 | 102808 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL259843 | 102808 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10462598 | 120913 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | ||
CHEMBL332909 | 120913 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | ||
10259447 | 23700 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | ||
CHEMBL125280 | 23700 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | ||
CHEMBL938 | 222686 | 28 | None | -1 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2010.07.034 | ||||
10462933 | 23654 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL125008 | 23654 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10462598 | 120913 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | ||
CHEMBL332909 | 120913 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | ||
10009984 | 119957 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331455 | 119957 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | ||
15292112 | 109725 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL306361 | 109725 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
44314780 | 109855 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL307430 | 109855 | 0 | None | - | 0 | Rat | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10101690 | 123639 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338137 | 123639 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
8374 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | ||
9937291 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL34124 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | ||
DB16266 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)80517-5 | ||
10327309 | 120668 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | ||
CHEMBL332576 | 120668 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | ||
10372451 | 124072 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339605 | 124072 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
8374 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | ||
9937291 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL34124 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | ||
DB16266 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/S0960-894X(01)81122-7 | ||
44338834 | 14630 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
CHEMBL108981 | 14630 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
44338834 | 14630 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL108981 | 14630 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
44303887 | 210100 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL64861 | 210100 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
8374 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | ||
9937291 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | ||
CHEMBL34124 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | ||
DB16266 | 9696 | 42 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/jm9504722 | ||
44315344 | 111858 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311386 | 111858 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2021.128086 | ||||
11765454 | 124846 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL340473 | 124846 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10349897 | 121205 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL333224 | 121205 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44315058 | 77228 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL194608 | 77228 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315059 | 211491 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74144 | 211491 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10101606 | 22543 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122273 | 22543 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL385283 | 219126 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
19430475 | 211031 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL71125 | 211031 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
9940350 | 211537 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | ||
CHEMBL74573 | 211537 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | ||
9851889 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | ||
9940350 | 211537 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL74573 | 211537 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
10031067 | 107128 | 4 | None | -2 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | ||
CHEMBL289614 | 107128 | 4 | None | -2 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | ||
10031067 | 107128 | 4 | None | -2 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL289614 | 107128 | 4 | None | -2 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | ||
10031067 | 107128 | 4 | None | -2 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
CHEMBL289614 | 107128 | 4 | None | -2 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
44283174 | 106850 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL287250 | 106850 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
9851889 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | ||
9851889 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | ||
9851889 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | ||
10395076 | 175355 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL435811 | 175355 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44315058 | 77228 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL194608 | 77228 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
9851889 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
44303886 | 107657 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL293660 | 107657 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
9851889 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | ||
9851889 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | ||
9851889 | 108851 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | ||
44315057 | 211608 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL75401 | 211608 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10078475 | 120107 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331632 | 120107 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44283175 | 127148 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL35324 | 127148 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
44315304 | 211789 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL76821 | 211789 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44314823 | 168665 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL415073 | 168665 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
9874508 | 211459 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL73876 | 211459 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10439819 | 176668 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL444065 | 176668 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44338697 | 116436 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | ||
CHEMBL322471 | 116436 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | ||
10372550 | 171295 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL421478 | 171295 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
15292112 | 109725 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL306361 | 109725 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
44314780 | 109855 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL307430 | 109855 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10462573 | 123787 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338889 | 123787 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL414533 | 219915 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
10259265 | 116820 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL323506 | 116820 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10327309 | 120668 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | ||
CHEMBL332576 | 120668 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | ||
10439837 | 23125 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL122917 | 23125 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
9892451 | 55514 | 23 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL155836 | 55514 | 23 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
10010164 | 124175 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL339806 | 124175 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10032988 | 123695 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338434 | 123695 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
11765454 | 124846 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL340473 | 124846 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10100951 | 121822 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
CHEMBL334300 | 121822 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
20647138 | 107248 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL290829 | 107248 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
9918412 | 211041 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL71172 | 211041 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
19430479 | 211048 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL71220 | 211048 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
10462053 | 174836 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 15 | 4 | 8 | 5.9 | CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL432378 | 174836 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 15 | 4 | 8 | 5.9 | CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
10327728 | 104898 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL273542 | 104898 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44315282 | 103399 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL263452 | 103399 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | ||
9917399 | 108923 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL302519 | 108923 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
9917399 | 108923 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | ||
CHEMBL302519 | 108923 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | ||
44315349 | 67164 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL17487 | 67164 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44311675 | 108931 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL302579 | 108931 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311676 | 109838 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL307318 | 109838 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
44311412 | 112106 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL311625 | 112106 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311072 | 210965 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70789 | 210965 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311736 | 210986 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70867 | 210986 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311452 | 211284 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL72595 | 211284 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
15780095 | 105371 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL276853 | 105371 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
15780091 | 127774 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL35638 | 127774 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
9851082 | 107797 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL294512 | 107797 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(01)80554-0 | ||
9810305 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL276674 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
9810305 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
CHEMBL276674 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
1037 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | ||
3940 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | ||
5281037 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | ||
588 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | ||
CHEMBL813 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | ||
DB00876 | 8359 | 69 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1021/jm00108a043 | ||
9810305 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
CHEMBL276674 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
44315144 | 103367 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL263191 | 103367 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
9851082 | 107797 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | ||
CHEMBL294512 | 107797 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | ||
10395395 | 114071 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL317159 | 114071 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 768 | 17 | 1 | 10 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
10033013 | 118430 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 750 | 17 | 1 | 10 | 7.3 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm00015a016 | ||
CHEMBL328602 | 118430 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 750 | 17 | 1 | 10 | 7.3 | CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1021/jm00015a016 | ||
9937227 | 208951 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | ||
CHEMBL60942 | 208951 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | ||
10078661 | 215026 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 733 | 17 | 1 | 9 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL98746 | 215026 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 733 | 17 | 1 | 9 | 7.4 | CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
10259277 | 215093 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 715 | 18 | 1 | 9 | 7.4 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 | 10.1021/jm00015a016 | ||
CHEMBL99112 | 215093 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 715 | 18 | 1 | 9 | 7.4 | CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 | 10.1021/jm00015a016 | ||
44315304 | 211789 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL76821 | 211789 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315057 | 211608 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL75401 | 211608 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL5272027 | 201389 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 846 | 21 | 4 | 9 | 8.0 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O | 10.1016/j.ejmech.2019.111852 | ||
CHEMBL5315276 | 201389 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 846 | 21 | 4 | 9 | 8.0 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O | 10.1016/j.ejmech.2019.111852 | ||
44322202 | 113648 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 692 | 17 | 4 | 8 | 6.7 | CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL314506 | 113648 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 692 | 17 | 4 | 8 | 6.7 | CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44322203 | 113711 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 650 | 13 | 4 | 8 | 5.4 | CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL314827 | 113711 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 650 | 13 | 4 | 8 | 5.4 | CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44321791 | 213392 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 14 | 4 | 8 | 6.0 | CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL89053 | 213392 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 14 | 4 | 8 | 6.0 | CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
10078554 | 123746 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338687 | 123746 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
11765560 | 22309 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL121872 | 22309 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10417321 | 22390 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122157 | 22390 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
9810305 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
CHEMBL276674 | 105348 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
10485116 | 123631 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338101 | 123631 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | ||
18965174 | 107645 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 507 | 12 | 1 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL293625 | 107645 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 507 | 12 | 1 | 3 | 5.2 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
9870559 | 53642 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 499 | 8 | 1 | 4 | 5.6 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL154057 | 53642 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 499 | 8 | 1 | 4 | 5.6 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
19939495 | 214604 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL96314 | 214604 | 0 | None | - | 0 | Rat | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10010071 | 124127 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339722 | 124127 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL216061 | 216095 | 15 | None | - | 2 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm00108a043 | ||||
10395335 | 123860 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339256 | 123860 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
10349897 | 121205 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL333224 | 121205 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10439858 | 23633 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL124903 | 23633 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44315060 | 109834 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL307290 | 109834 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL938 | 222686 | 28 | None | -1 | 2 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm00065a013 | ||||
15780089 | 106585 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL285432 | 106585 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
10349732 | 125531 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
CHEMBL341828 | 125531 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
10101351 | 175443 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL436396 | 175443 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10259489 | 23690 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | ||
CHEMBL125231 | 23690 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | ||
22850669 | 209765 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL63109 | 209765 | 0 | None | - | 0 | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
10321941 | 144925 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1021/jm00108a043 | ||
CHEMBL37679 | 144925 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 458 | 10 | 2 | 5 | 5.4 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl | 10.1021/jm00108a043 | ||
20647138 | 107248 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL290829 | 107248 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | ||
10033136 | 22845 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122380 | 22845 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10394859 | 24201 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL125760 | 24201 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
20647138 | 107248 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL290829 | 107248 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 520 | 5 | 1 | 3 | 6.0 | O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
19430442 | 210954 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70726 | 210954 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
10078663 | 214566 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL96075 | 214566 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | ||
10100951 | 121822 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
CHEMBL334300 | 121822 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
10078663 | 214566 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
CHEMBL96075 | 214566 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
44381553 | 127114 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL352947 | 127114 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10100951 | 121822 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
CHEMBL334300 | 121822 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
44315350 | 111995 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311484 | 111995 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
10417321 | 22390 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122157 | 22390 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44348523 | 119956 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL331450 | 119956 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
9870914 | 210106 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL64881 | 210106 | 0 | None | - | 0 | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
44299731 | 7208 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
585 | 7208 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
CHEMBL56448 | 7208 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
10395076 | 175355 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL435811 | 175355 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44315059 | 211491 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74144 | 211491 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
19430462 | 109761 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306638 | 109761 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44321824 | 212343 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 642 | 13 | 4 | 8 | 5.5 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL81236 | 212343 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 642 | 13 | 4 | 8 | 5.5 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | ||
22402434 | 55801 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 5 | 5.8 | COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL156100 | 55801 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 5 | 5.8 | COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81122-7 | ||
44311617 | 109316 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL304065 | 109316 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44311538 | 109740 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306435 | 109740 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
44311755 | 109911 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL307866 | 109911 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311071 | 110192 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL308482 | 110192 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
44311752 | 111642 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL311018 | 111642 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
10005139 | 64378 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 | 10.1016/j.bmc.2010.10.043 | ||
CHEMBL1668008 | 64378 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 | 10.1016/j.bmc.2010.10.043 | ||
14403498 | 107808 | 3 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | ||
CHEMBL294558 | 107808 | 3 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | ||
44303640 | 206892 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 511 | 12 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL59611 | 206892 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 511 | 12 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
44303208 | 209325 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 555 | 12 | 1 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL61168 | 209325 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 555 | 12 | 1 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | ||
44210590 | 65488 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL168490 | 65488 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10078475 | 120107 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331632 | 120107 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
18965184 | 209695 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 504 | 4 | 0 | 2 | 7.3 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL62806 | 209695 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 504 | 4 | 0 | 2 | 7.3 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
44330905 | 11182 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 746 | 19 | 1 | 8 | 8.2 | CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 | 10.1021/jm00015a016 | ||
CHEMBL101455 | 11182 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 746 | 19 | 1 | 8 | 8.2 | CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 | 10.1021/jm00015a016 | ||
9937227 | 208951 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | ||
CHEMBL60942 | 208951 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm00015a016 | ||
11755896 | 123750 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 505 | 7 | 1 | 3 | 5.8 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | ||
CHEMBL338709 | 123750 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 505 | 7 | 1 | 3 | 5.8 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | ||
11765541 | 125786 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL342605 | 125786 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
9988057 | 112938 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 831 | 10 | 5 | 15 | 3.3 | CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C | 10.1016/0960-894X(95)00477-B | ||
CHEMBL313691 | 112938 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 831 | 10 | 5 | 15 | 3.3 | CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C | 10.1016/0960-894X(95)00477-B | ||
44311496 | 211023 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL71069 | 211023 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44379292 | 127112 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL352934 | 127112 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
10077497 | 18141 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL1179757 | 18141 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL98426 | 18141 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | ||
44328276 | 119504 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | ||
CHEMBL330464 | 119504 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | ||
10077929 | 214124 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | ||
CHEMBL93606 | 214124 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | ||
15818748 | 106689 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
CHEMBL286134 | 106689 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
44311571 | 211234 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL72249 | 211234 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44303248 | 209532 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 414 | 8 | 1 | 6 | 4.4 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL61976 | 209532 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 414 | 8 | 1 | 6 | 4.4 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C | 10.1016/S0960-894X(01)80554-0 | ||
44311567 | 109790 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL306922 | 109790 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44311450 | 110878 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL309365 | 110878 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44311497 | 174636 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL430997 | 174636 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44311664 | 210942 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL70638 | 210942 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44377125 | 62413 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL162148 | 62413 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
1610 | 9126 | 95 | None | - | 4 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | ||
3941 | 9126 | 95 | None | - | 4 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | ||
3961 | 9126 | 95 | None | - | 4 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | ||
590 | 9126 | 95 | None | - | 4 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL191 | 9126 | 95 | None | - | 4 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | ||
DB00678 | 9126 | 95 | None | - | 4 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | ||
44376747 | 126867 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL350851 | 126867 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
9852384 | 107192 | 5 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
CHEMBL290214 | 107192 | 5 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
9852384 | 107192 | 5 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm049715t | ||
CHEMBL290214 | 107192 | 5 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm049715t | ||
9852384 | 107192 | 5 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | ||
CHEMBL290214 | 107192 | 5 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | ||
23583071 | 194997 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1450 | 7 | 8 | 31 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL499234 | 194997 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1450 | 7 | 8 | 31 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
164613196 | 192218 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 951 | 23 | 12 | 10 | 1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4861538 | 192218 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 951 | 23 | 12 | 10 | 1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | ||
10440203 | 125765 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL342492 | 125765 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44315058 | 77228 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL194608 | 77228 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315344 | 111858 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311386 | 111858 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10258694 | 119364 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL330165 | 119364 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | ||
10233073 | 214412 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL95198 | 214412 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | ||
10438523 | 214923 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL98126 | 214923 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | ||
57380412 | 77303 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
CHEMBL1947129 | 77303 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
15296724 | 126796 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 462 | 7 | 2 | 5 | 4.3 | COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL350220 | 126796 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 462 | 7 | 2 | 5 | 4.3 | COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 | 10.1016/S0960-894X(01)81122-7 | ||
11757357 | 214771 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97273 | 214771 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
23584461 | 185452 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1368 | 7 | 9 | 30 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL467872 | 185452 | 1 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 1368 | 7 | 9 | 30 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
90663955 | 113553 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1280 | 38 | 16 | 17 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O | 10.1021/jm00065a013 | ||
CHEMBL3144487 | 113553 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1280 | 38 | 16 | 17 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O | 10.1021/jm00065a013 | ||
164625885 | 193045 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4873899 | 193045 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
44303458 | 174661 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 12 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL431137 | 174661 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 12 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | ||
10417251 | 103680 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL265797 | 103680 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
19939453 | 119168 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL329679 | 119168 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10417251 | 103680 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL265797 | 103680 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL413925 | 219881 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 | 10.1021/jm00065a013 | ||||
44381724 | 127086 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL352771 | 127086 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10259265 | 116820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL323506 | 116820 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
44315180 | 109673 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL305956 | 109673 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44373238 | 103862 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | ||
CHEMBL267354 | 103862 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | ||
44304147 | 107553 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL292939 | 107553 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | ||
44315057 | 211608 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL75401 | 211608 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44322236 | 119605 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 636 | 14 | 4 | 8 | 5.4 | CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL330744 | 119605 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 636 | 14 | 4 | 8 | 5.4 | CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44323447 | 113678 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 627 | 11 | 1 | 9 | 6.5 | CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL314605 | 113678 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 627 | 11 | 1 | 9 | 6.5 | CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44379269 | 63942 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL164769 | 63942 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
10438745 | 113993 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL316655 | 113993 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | ||
10349597 | 118395 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL328434 | 118395 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | ||
10416475 | 214483 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL95579 | 214483 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | ||
44300735 | 107537 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL292829 | 107537 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
46910582 | 77128 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
CHEMBL1945009 | 77128 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
19385652 | 54292 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15458 | 54292 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
19385680 | 105657 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | ||
CHEMBL279103 | 105657 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | ||
15696755 | 154802 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
CHEMBL39345 | 154802 | 1 | None | - | 0 | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 306 | 7 | 1 | 3 | 3.6 | CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
44323530 | 213959 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 586 | 10 | 1 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL92479 | 213959 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 586 | 10 | 1 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
10259395 | 33768 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL136465 | 33768 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44381552 | 127065 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL352629 | 127065 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10349659 | 118320 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL327988 | 118320 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | ||
10439275 | 174839 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL432392 | 174839 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | ||
10054753 | 214925 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL98140 | 214925 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
44300615 | 203562 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL56549 | 203562 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | ||
44373417 | 59157 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | ||
CHEMBL159004 | 59157 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | ||
57380649 | 77150 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
CHEMBL1945149 | 77150 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
11765394 | 125555 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | ||
CHEMBL341986 | 125555 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | ||
19939409 | 113937 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL316299 | 113937 | 0 | None | - | 0 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
136026557 | 213641 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 617 | 11 | 1 | 10 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL90663 | 213641 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 617 | 11 | 1 | 10 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44309903 | 211173 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL71925 | 211173 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
19939495 | 214604 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL96314 | 214604 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
44309903 | 211173 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
CHEMBL71925 | 211173 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
44270330 | 58520 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15847 | 58520 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
57380647 | 77129 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
CHEMBL1945010 | 77129 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
10349791 | 118356 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL328176 | 118356 | 0 | None | - | 0 | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | ||
10008962 | 126051 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL343719 | 126051 | 0 | None | - | 0 | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
73347893 | 99401 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435828 | 99401 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
10484866 | 38559 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
CHEMBL140619 | 38559 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
44322097 | 113883 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 608 | 12 | 4 | 8 | 4.6 | CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL315994 | 113883 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 608 | 12 | 4 | 8 | 4.6 | CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44381425 | 127232 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL353980 | 127232 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
18965154 | 107376 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 490 | 4 | 0 | 2 | 6.9 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL291818 | 107376 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 490 | 4 | 0 | 2 | 6.9 | CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
44303880 | 209752 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 508 | 12 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL63046 | 209752 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 508 | 12 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 | 10.1016/S0960-894X(01)81007-6 | ||
44304044 | 209965 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 4.3 | CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL64280 | 209965 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 4.3 | CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
44323293 | 113810 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 629 | 14 | 1 | 9 | 6.8 | CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O | 10.1016/0960-894X(95)00477-B | ||
CHEMBL315483 | 113810 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 629 | 14 | 1 | 9 | 6.8 | CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O | 10.1016/0960-894X(95)00477-B | ||
44323357 | 119164 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 648 | 11 | 1 | 8 | 6.7 | CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL329655 | 119164 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 648 | 11 | 1 | 8 | 6.7 | CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44323352 | 213329 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 573 | 9 | 1 | 9 | 5.2 | CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL88663 | 213329 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 573 | 9 | 1 | 9 | 5.2 | CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
10326775 | 119016 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329089 | 119016 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | ||
10483726 | 214355 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL94910 | 214355 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | ||
10349506 | 214838 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97615 | 214838 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | ||
44300637 | 107702 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL293949 | 107702 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | ||
10100413 | 205369 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL57853 | 205369 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
15296725 | 172064 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 9 | 0 | 5 | 5.9 | CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL423236 | 172064 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 9 | 0 | 5 | 5.9 | CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
46910583 | 77127 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
CHEMBL1945008 | 77127 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
44379348 | 171700 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL422374 | 171700 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
10439172 | 214262 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | ||
CHEMBL94355 | 214262 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | ||
44377171 | 126989 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | ||
CHEMBL352042 | 126989 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | ||
15287894 | 61721 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL16148 | 61721 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | ||
44381739 | 65559 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL168771 | 65559 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
44381739 | 65559 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL168771 | 65559 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | ||
10326797 | 214353 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL94905 | 214353 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | ||
10326460 | 214886 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97897 | 214886 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
44327912 | 214914 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | ||
CHEMBL98068 | 214914 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | ||
44348153 | 124748 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | ||
CHEMBL340367 | 124748 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | ||
44210836 | 63283 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | ||
CHEMBL163523 | 63283 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | ||
73357017 | 99404 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435831 | 99404 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | ||
44323532 | 213913 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL92206 | 213913 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
9830680 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL292150 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
9830680 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
CHEMBL292150 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
10372497 | 125524 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL341783 | 125524 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
9830680 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL292150 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
10078800 | 115968 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL321531 | 115968 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
9830680 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | ||
CHEMBL292150 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | ||
19754050 | 210659 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL68786 | 210659 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | ||
44381528 | 65767 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169009 | 65767 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10394995 | 118171 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL327191 | 118171 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | ||
10077743 | 214736 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97068 | 214736 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | ||
44304148 | 210068 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 4 | 1 | 3 | 4.3 | CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL64714 | 210068 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 4 | 1 | 3 | 4.3 | CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
22402428 | 55525 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 450 | 6 | 2 | 4 | 4.5 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL155847 | 55525 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 450 | 6 | 2 | 4 | 4.5 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
15229605 | 54928 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15517 | 54928 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | ||
44323448 | 103625 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL265291 | 103625 | 0 | None | - | 0 | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 559 | 10 | 2 | 8 | 5.1 | CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
11764788 | 107635 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL293501 | 107635 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
9810305 | 105348 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
CHEMBL276674 | 105348 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
9895212 | 126418 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | ||
CHEMBL346728 | 126418 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | ||
44385182 | 67848 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL176473 | 67848 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | ||
10031920 | 114764 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL319404 | 114764 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | ||
44372814 | 126568 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | ||
CHEMBL348157 | 126568 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | ||
44303888 | 210058 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL64674 | 210058 | 0 | None | - | 0 | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
10390872 | 122924 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | ||
CHEMBL335778 | 122924 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | ||
44377086 | 126729 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL349652 | 126729 | 0 | None | - | 0 | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
10101582 | 126154 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | ||
CHEMBL344466 | 126154 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | ||
5311348 | 107449 | 4 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL292277 | 107449 | 4 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1016/S0960-894X(01)81007-6 | ||
10484986 | 125475 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL341715 | 125475 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
1952 | 8990 | 4 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | ||
5312129 | 8990 | 4 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | ||
CHEMBL1182768 | 8990 | 4 | None | - | 2 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | ||
9960852 | 113959 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | ||
CHEMBL316482 | 113959 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | ||
10416957 | 118276 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL327791 | 118276 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | ||
10010125 | 214810 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97464 | 214810 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | ||
136059719 | 195908 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1438 | 10 | 9 | 31 | 4.5 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL510526 | 195908 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 1438 | 10 | 9 | 31 | 4.5 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
44300827 | 108544 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL299897 | 108544 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
44348355 | 120164 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | ||
CHEMBL331797 | 120164 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | ||
44311289 | 109002 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL302964 | 109002 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311455 | 109521 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL305017 | 109521 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311754 | 109774 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306761 | 109774 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311715 | 109973 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL308323 | 109973 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311435 | 210801 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL69721 | 210801 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311434 | 210903 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70370 | 210903 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311414 | 211002 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70935 | 211002 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311413 | 211130 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL71639 | 211130 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311753 | 211390 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL73283 | 211390 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
3936 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | ||
6603900 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | ||
CHEMBL288174 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | ||
44303191 | 174665 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 12 | 1 | 7 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL431162 | 174665 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 12 | 1 | 7 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | ||
3936 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | ||
6603900 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | ||
CHEMBL288174 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | ||
3936 | 8991 | 35 | None | - | 4 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2010.03.064 | ||
6603900 | 8991 | 35 | None | - | 4 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2010.03.064 | ||
CHEMBL288174 | 8991 | 35 | None | - | 4 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2010.03.064 | ||
44322095 | 113787 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL315327 | 113787 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
10259841 | 22930 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL122401 | 22930 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10259447 | 23700 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | ||
CHEMBL125280 | 23700 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | ||
11765177 | 123786 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338888 | 123786 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
3936 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | ||
6603900 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | ||
CHEMBL288174 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | ||
44372744 | 58925 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | ||
CHEMBL158795 | 58925 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | ||
3936 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | ||
6603900 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | ||
CHEMBL288174 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | ||
19430458 | 210853 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70100 | 210853 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
10010234 | 105203 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL275552 | 105203 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
10078320 | 213294 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 684 | 13 | 4 | 8 | 5.8 | CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL88446 | 213294 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 684 | 13 | 4 | 8 | 5.8 | CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44381426 | 127050 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL352502 | 127050 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10349897 | 121205 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL333224 | 121205 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10259489 | 23690 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | ||
CHEMBL125231 | 23690 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | ||
10078780 | 123694 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338433 | 123694 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10259468 | 125259 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL341369 | 125259 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44309938 | 211079 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL71388 | 211079 | 0 | None | - | 0 | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
19802473 | 205484 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
CHEMBL58156 | 205484 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
10439862 | 125550 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL341934 | 125550 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
10010195 | 125962 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL343142 | 125962 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
10032851 | 23607 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL124771 | 23607 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10485116 | 123631 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
CHEMBL338101 | 123631 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | ||
9895984 | 211528 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL74476 | 211528 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10485116 | 123631 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338101 | 123631 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | ||
10372810 | 112979 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL313868 | 112979 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
44315180 | 109673 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL305956 | 109673 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
9895984 | 211528 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74476 | 211528 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | ||
9892451 | 55514 | 23 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL155836 | 55514 | 23 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
9895984 | 211528 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | ||
CHEMBL74476 | 211528 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | ||
10101284 | 214181 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL93907 | 214181 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
10101284 | 214181 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL93907 | 214181 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm00065a013 | ||||
11765560 | 22309 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL121872 | 22309 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10010071 | 124127 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339722 | 124127 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10101284 | 214181 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | ||
CHEMBL93907 | 214181 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | ||
44315060 | 109834 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL307290 | 109834 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
10032877 | 22321 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL121907 | 22321 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10462683 | 120059 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331507 | 120059 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10417195 | 115856 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL321313 | 115856 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
44310069 | 210517 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL67801 | 210517 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
10009984 | 119957 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL331455 | 119957 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | ||
44303884 | 209612 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL62422 | 209612 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
44381403 | 65940 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169968 | 65940 | 0 | None | - | 0 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10259657 | 126171 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL344597 | 126171 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44381413 | 127500 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL354779 | 127500 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
9987414 | 123827 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339113 | 123827 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
44311453 | 210816 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL69839 | 210816 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
44311557 | 211062 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL71286 | 211062 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
44311558 | 211501 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL74236 | 211501 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44303388 | 169686 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 539 | 12 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL417393 | 169686 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 539 | 12 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | ||
44303459 | 207066 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 13 | 1 | 10 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL59728 | 207066 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 13 | 1 | 10 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)80554-0 | ||
44303197 | 209015 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 619 | 12 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL60992 | 209015 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 619 | 12 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 | 10.1016/S0960-894X(01)80554-0 | ||
10394727 | 109839 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL307321 | 109839 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44210589 | 65370 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL168413 | 65370 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
11765454 | 124846 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL340473 | 124846 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10092454 | 107023 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 401 | 7 | 2 | 5 | 4.9 | CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00037a014 | ||
CHEMBL288705 | 107023 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 401 | 7 | 2 | 5 | 4.9 | CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00037a014 | ||
44303859 | 207770 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL60209 | 207770 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
9896877 | 67006 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL174080 | 67006 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | ||
44311584 | 109557 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL305239 | 109557 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44311406 | 110584 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL309081 | 110584 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
10480819 | 28578 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 492 | 6 | 1 | 3 | 6.1 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
CHEMBL131940 | 28578 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 492 | 6 | 1 | 3 | 6.1 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
44311635 | 109001 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL302959 | 109001 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | ||
44311499 | 211178 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL71953 | 211178 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | ||
44384389 | 136615 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL367569 | 136615 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | ||
10429298 | 25674 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL128416 | 25674 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
44210864 | 154884 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
CHEMBL39352 | 154884 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
9850811 | 161519 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
CHEMBL39996 | 161519 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
44311616 | 108917 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL302485 | 108917 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44311776 | 109792 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306924 | 109792 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
10255071 | 170243 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 491 | 6 | 0 | 4 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL419974 | 170243 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 491 | 6 | 0 | 4 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
9981762 | 170245 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 461 | 5 | 0 | 3 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL419979 | 170245 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 461 | 5 | 0 | 3 | 5.6 | COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44379347 | 127265 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL354338 | 127265 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
44377075 | 126755 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL349869 | 126755 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
15287882 | 56517 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15670 | 56517 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
22407453 | 56532 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15671 | 56532 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
9987311 | 123535 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL337588 | 123535 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
14952914 | 161689 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 410 | 9 | 2 | 5 | 5.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 | 10.1021/jm00108a043 | ||
CHEMBL40089 | 161689 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 410 | 9 | 2 | 5 | 5.1 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 | 10.1021/jm00108a043 | ||
44338666 | 117735 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
CHEMBL326217 | 117735 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
44379335 | 126999 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL352137 | 126999 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
44379293 | 127068 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL352639 | 127068 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
44376780 | 63278 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL163486 | 63278 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
44300734 | 108583 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL300154 | 108583 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
10049400 | 162219 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | ||
CHEMBL40381 | 162219 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | ||
44323358 | 119282 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 626 | 10 | 1 | 8 | 6.0 | CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL329887 | 119282 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 626 | 10 | 1 | 8 | 6.0 | CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
19939398 | 114111 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL317547 | 114111 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | ||
10055534 | 164240 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
CHEMBL407919 | 164240 | 0 | None | - | 0 | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
44338833 | 15951 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
CHEMBL110265 | 15951 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
15231091 | 100763 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
CHEMBL24861 | 100763 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
15231091 | 100763 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
CHEMBL24861 | 100763 | 0 | None | - | 0 | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
CHEMBL443325 | 220700 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSSC[C@H](C(=O)N[C@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C[C@H](CN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)SS2 | 10.1021/jm00065a013 | ||||
44303857 | 107587 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL293195 | 107587 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | ||
10417144 | 39754 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL141592 | 39754 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44303852 | 109126 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL303755 | 109126 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
18950586 | 22336 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | ||
CHEMBL122017 | 22336 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | ||
44377058 | 126784 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL350121 | 126784 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
10482937 | 173916 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL321086 | 173916 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL429058 | 173916 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
14956757 | 74367 | 0 | None | - | 1 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | ||
CHEMBL19018 | 74367 | 0 | None | - | 1 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | ||
14956757 | 74367 | 0 | None | - | 1 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL19018 | 74367 | 0 | None | - | 1 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | ||
4189 | 213701 | 96 | None | -38 | 34 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL1559 | 213701 | 96 | None | -38 | 34 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL91 | 213701 | 96 | None | -38 | 34 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
71455883 | 90539 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | ||
CHEMBL2205685 | 90539 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 495 | 6 | 2 | 7 | 4.7 | O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | ||
44372686 | 103430 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | ||
CHEMBL263714 | 103430 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | ||
44211677 | 137392 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL368149 | 137392 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | ||
164623569 | 192966 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1008 | 26 | 12 | 10 | 2.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4872735 | 192966 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1008 | 26 | 12 | 10 | 2.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | ||
44348302 | 23263 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | ||
CHEMBL123562 | 23263 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | ||
11764826 | 105060 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL274710 | 105060 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | ||
44348302 | 23263 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | ||
CHEMBL123562 | 23263 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | ||
10028460 | 123299 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | ||
CHEMBL336180 | 123299 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | ||
10349512 | 214786 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97332 | 214786 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
19385665 | 57835 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15788 | 57835 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | ||
10028815 | 214874 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97783 | 214874 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | ||
CHEMBL411657 | 219733 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CSS2)N(C(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C1 | 10.1021/jm00065a013 | ||||
10078397 | 18881 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL1184032 | 18881 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329290 | 18881 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | ||
168298448 | 199482 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 477 | 5 | 2 | 4 | 5.8 | O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | ||
CHEMBL5219534 | 199482 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 477 | 5 | 2 | 4 | 5.8 | O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O | 10.1016/j.ejmech.2020.112872 | ||
44211576 | 113895 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 573 | 10 | 1 | 9 | 5.2 | CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL316063 | 113895 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 573 | 10 | 1 | 9 | 5.2 | CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
136059721 | 195777 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 1537 | 12 | 10 | 33 | 3.3 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL508699 | 195777 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 1537 | 12 | 10 | 33 | 3.3 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
10429298 | 25674 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL128416 | 25674 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 371 | 4 | 1 | 2 | 3.9 | O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44300838 | 205449 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL57976 | 205449 | 0 | None | - | 0 | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
10009968 | 119324 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329942 | 119324 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | ||
10372341 | 174977 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL433375 | 174977 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | ||
16725318 | 195742 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 1494 | 11 | 9 | 32 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL508306 | 195742 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 1494 | 11 | 9 | 32 | 4.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
192626 | 22431 | 14 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | ||
CHEMBL122212 | 22431 | 14 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | ||
9978845 | 137490 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
CHEMBL36846 | 137490 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 408 | 9 | 1 | 3 | 5.6 | CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
CHEMBL417584 | 220014 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
9939191 | 105722 | 1 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | ||
CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | ||
CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | ||
10326972 | 119038 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329099 | 119038 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | ||
10077555 | 214189 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | ||
CHEMBL93956 | 214189 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | ||
19102815 | 214657 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL96554 | 214657 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
19385603 | 105555 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL278234 | 105555 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL408885 | 219515 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
19754062 | 109762 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL306641 | 109762 | 0 | None | - | 0 | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
10349029 | 214875 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97812 | 214875 | 0 | None | - | 0 | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | ||
9888865 | 64271 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | ||
CHEMBL165974 | 64271 | 0 | None | - | 0 | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | ||
10055448 | 37536 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL139582 | 37536 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44379334 | 64885 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL167584 | 64885 | 1 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
44381603 | 65890 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169798 | 65890 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
133031 | 107636 | 21 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | ||
CHEMBL293511 | 107636 | 21 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | ||
133031 | 107636 | 21 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | ||
CHEMBL293511 | 107636 | 21 | None | - | 1 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | ||
19385675 | 58148 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15816 | 58148 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | ||
44311537 | 109109 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL303647 | 109109 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311580 | 109556 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL305238 | 109556 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311182 | 109804 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL307008 | 109804 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
44311619 | 109847 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL307359 | 109847 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311185 | 110968 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL309790 | 110968 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311073 | 210979 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70843 | 210979 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311184 | 211200 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL72099 | 211200 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | ||
44311183 | 211479 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL74069 | 211479 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311735 | 211531 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL74514 | 211531 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
9937227 | 208951 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL60942 | 208951 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | ||
9851082 | 107797 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL294512 | 107797 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
9987283 | 168721 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 705 | 16 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL415502 | 168721 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 705 | 16 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
133031 | 107636 | 21 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL293511 | 107636 | 21 | None | - | 1 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
9937227 | 208951 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm9504722 | ||
CHEMBL60942 | 208951 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 | 10.1021/jm9504722 | ||
10032820 | 124082 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339672 | 124082 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
10372659 | 124868 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL340632 | 124868 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44315351 | 111662 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311160 | 111662 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
44381402 | 65939 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169967 | 65939 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
15780064 | 106399 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL284123 | 106399 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
44381671 | 127205 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL353800 | 127205 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
15292113 | 102808 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL259843 | 102808 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10032858 | 36534 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL138690 | 36534 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | ||
9853391 | 123617 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338027 | 123617 | 1 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10439715 | 123813 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339040 | 123813 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10350123 | 64377 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | ||
CHEMBL1668007 | 64377 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | ||
19939418 | 115047 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL319730 | 115047 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
19939495 | 214604 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL96314 | 214604 | 0 | None | - | 0 | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
10395335 | 123860 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339256 | 123860 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | ||
44315144 | 103367 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL263191 | 103367 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44381527 | 65848 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169568 | 65848 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
44210588 | 127123 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL353037 | 127123 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10440144 | 123672 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338342 | 123672 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10462573 | 123787 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338889 | 123787 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44382947 | 66007 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 813 | 19 | 4 | 12 | 6.4 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 | 10.1016/S0960-894X(00)80690-3 | ||
CHEMBL170290 | 66007 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 813 | 19 | 4 | 12 | 6.4 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 | 10.1016/S0960-894X(00)80690-3 | ||
10101608 | 123807 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL339004 | 123807 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10372451 | 124072 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL339605 | 124072 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10010164 | 124175 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL339806 | 124175 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
10101284 | 214181 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | ||
CHEMBL93907 | 214181 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | ||
9850834 | 161441 | 17 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
CHEMBL39959 | 161441 | 17 | None | - | 1 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
10032988 | 123695 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL338434 | 123695 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44321825 | 113887 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL316021 | 113887 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 636 | 13 | 4 | 8 | 5.1 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44309700 | 109962 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL308237 | 109962 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
10433752 | 25693 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL128527 | 25693 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44283372 | 107196 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL290286 | 107196 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80517-5 | ||
9875044 | 214808 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97446 | 214808 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | ||
44303835 | 108543 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 494 | 11 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL299887 | 108543 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 494 | 11 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 | 10.1016/S0960-894X(01)81007-6 | ||
44283372 | 107196 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm9504722 | ||
CHEMBL290286 | 107196 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm9504722 | ||
44311609 | 109585 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL305369 | 109585 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44311428 | 109746 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306473 | 109746 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44311583 | 210899 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70353 | 210899 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
11740800 | 25609 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 4.2 | Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | ||
CHEMBL128065 | 25609 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 4.2 | Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | ||
10386376 | 25709 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 402 | 4 | 1 | 3 | 4.5 | CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL128594 | 25709 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 402 | 4 | 1 | 3 | 4.5 | CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 | 10.1021/jm00077a001 | ||
9939191 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | ||
CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | ||
CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | ||
44323387 | 112764 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 11 | 2 | 8 | 5.6 | CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL313142 | 112764 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 11 | 2 | 8 | 5.6 | CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44323364 | 118677 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.6 | CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL328780 | 118677 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.6 | CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44311758 | 211450 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL73780 | 211450 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
9939191 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | ||
CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | ||
CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | ||
44379350 | 127563 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL355443 | 127563 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
9939191 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | ||
CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | ||
CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | ||
9939191 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
10348847 | 119366 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL330170 | 119366 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | ||
10054912 | 214411 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL95197 | 214411 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | ||
10054827 | 170917 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
CHEMBL42101 | 170917 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
19385729 | 57653 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15774 | 57653 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | ||
15818746 | 130847 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
CHEMBL36324 | 130847 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | ||
44311775 | 109791 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306923 | 109791 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44303636 | 175877 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 4.2 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL439936 | 175877 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 418 | 8 | 1 | 6 | 4.2 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(01)80554-0 | ||
44311681 | 109800 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL306961 | 109800 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44384870 | 66820 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL173643 | 66820 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | ||
44270285 | 105841 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL280456 | 105841 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
9980304 | 105312 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | ||
CHEMBL276381 | 105312 | 0 | None | - | 0 | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 433 | 9 | 3 | 8 | 1.4 | CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 | 10.1021/jm00053a013 | ||
10258916 | 36484 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
CHEMBL138654 | 36484 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | ||
14952906 | 107281 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] | 10.1021/jm00108a043 | ||
CHEMBL291086 | 107281 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] | 10.1021/jm00108a043 | ||
11764788 | 107635 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | ||
CHEMBL293501 | 107635 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | ||
10439253 | 119098 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329255 | 119098 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | ||
164611280 | 191778 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4854474 | 191778 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
10077328 | 213251 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 601 | 11 | 1 | 9 | 6.0 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL88170 | 213251 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 601 | 11 | 1 | 9 | 6.0 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44315060 | 109834 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL307290 | 109834 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
44404967 | 142196 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | ||
CHEMBL372814 | 142196 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | ||
44323345 | 113781 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 557 | 10 | 1 | 8 | 5.6 | CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL315302 | 113781 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 557 | 10 | 1 | 8 | 5.6 | CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
10372723 | 114095 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL317368 | 114095 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
15231094 | 146075 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL37919 | 146075 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
44309719 | 210633 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL68638 | 210633 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
44323365 | 118852 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 619 | 11 | 1 | 8 | 6.9 | CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL328997 | 118852 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 619 | 11 | 1 | 8 | 6.9 | CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44379270 | 63631 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL164395 | 63631 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
10010027 | 214811 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97465 | 214811 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
130762 | 105023 | 9 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00053a013 | ||
CHEMBL274447 | 105023 | 9 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00053a013 | ||
44270306 | 58951 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15882 | 58951 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | ||
5311345 | 9795 | 46 | None | 10 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm049715t | ||
597 | 9795 | 46 | None | 10 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm049715t | ||
CHEMBL321820 | 9795 | 46 | None | 10 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm049715t | ||
10394712 | 126155 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL344467 | 126155 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
122189454 | 130034 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 4.1 | COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C | 10.1016/j.bmc.2015.07.045 | ||
CHEMBL3613974 | 130034 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 4.1 | COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C | 10.1016/j.bmc.2015.07.045 | ||
5311345 | 9795 | 46 | None | - | 2 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm9504722 | ||
597 | 9795 | 46 | None | - | 2 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm9504722 | ||
CHEMBL321820 | 9795 | 46 | None | - | 2 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/jm9504722 | ||
44379217 | 64923 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL167929 | 64923 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
15287883 | 104986 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL274260 | 104986 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
10461785 | 18695 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL1182712 | 18695 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL262296 | 18695 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | ||
10032342 | 214801 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97394 | 214801 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | ||
44303941 | 210034 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 580 | 13 | 1 | 5 | 6.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL64575 | 210034 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 580 | 13 | 1 | 5 | 6.0 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
22402431 | 55874 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 575 | 8 | 1 | 4 | 6.8 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL156165 | 55874 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 575 | 8 | 1 | 4 | 6.8 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
44384871 | 136098 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL367095 | 136098 | 0 | None | - | 0 | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | ||
18950609 | 23177 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | ||
CHEMBL123084 | 23177 | 0 | None | - | 0 | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | ||
44321626 | 112743 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 616 | 14 | 3 | 9 | 4.8 | CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL313005 | 112743 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 616 | 14 | 3 | 9 | 4.8 | CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | ||
9809961 | 113938 | 2 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL316300 | 113938 | 2 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
9809961 | 113938 | 2 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL316300 | 113938 | 2 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
9809961 | 113938 | 2 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL316300 | 113938 | 2 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | ||
44323350 | 113796 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL315400 | 113796 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
57380414 | 77305 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
CHEMBL1947131 | 77305 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
10028545 | 27777 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | ||
CHEMBL131156 | 27777 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | ||
10009273 | 114002 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL316706 | 114002 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | ||
15236320 | 179385 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
CHEMBL449095 | 179385 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
44315059 | 211491 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74144 | 211491 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
2911265 | 107619 | 13 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 476 | 4 | 0 | 2 | 6.5 | O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL293414 | 107619 | 13 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 476 | 4 | 0 | 2 | 6.5 | O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | ||
183134 | 211623 | 17 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL7550 | 211623 | 17 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
9938088 | 109258 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | ||
CHEMBL304022 | 109258 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | ||
15230315 | 61211 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 552 | 8 | 0 | 7 | 5.7 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL160930 | 61211 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 552 | 8 | 0 | 7 | 5.7 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
14403498 | 107808 | 3 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL294558 | 107808 | 3 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1016/S0960-894X(01)81007-6 | ||
44322234 | 213487 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 13 | 3 | 8 | 5.1 | CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL89769 | 213487 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 620 | 13 | 3 | 8 | 5.1 | CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
9986299 | 165230 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | ||
CHEMBL409058 | 165230 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | ||
44322235 | 119426 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 620 | 13 | 3 | 7 | 6.0 | CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL330302 | 119426 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 620 | 13 | 3 | 7 | 6.0 | CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
10032193 | 125923 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL342843 | 125923 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44211506 | 64315 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL166338 | 64315 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
44311456 | 109075 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL303427 | 109075 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
71611145 | 191641 | 2 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4852514 | 191641 | 2 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
44303195 | 209993 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 559 | 12 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL64411 | 209993 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 559 | 12 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 | 10.1016/S0960-894X(01)80554-0 | ||
44331176 | 215134 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 732 | 18 | 1 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL99438 | 215134 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 732 | 18 | 1 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
10010311 | 37300 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL139325 | 37300 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
10327728 | 104898 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL273542 | 104898 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10439819 | 176668 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL444065 | 176668 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
9850834 | 161441 | 17 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | ||
CHEMBL39959 | 161441 | 17 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | ||
9850834 | 161441 | 17 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL39959 | 161441 | 17 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmcl.2015.10.084 | ||
9850834 | 161441 | 17 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
CHEMBL39959 | 161441 | 17 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
19102786 | 213968 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL92533 | 213968 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | ||
44309702 | 210519 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL67805 | 210519 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
10439837 | 23125 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL122917 | 23125 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10462598 | 120913 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | ||
CHEMBL332909 | 120913 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | ||
10327537 | 123455 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL337118 | 123455 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
10439848 | 125988 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL343309 | 125988 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
9852499 | 127241 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL354080 | 127241 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
44314761 | 109631 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL305647 | 109631 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315350 | 111995 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311484 | 111995 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
44304123 | 207356 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL59913 | 207356 | 0 | None | - | 0 | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
44210585 | 127185 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL353615 | 127185 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | ||
10327309 | 120668 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | ||
CHEMBL332576 | 120668 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | ||
44322096 | 105177 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 622 | 12 | 4 | 8 | 4.8 | CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL275449 | 105177 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 622 | 12 | 4 | 8 | 4.8 | CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
10259411 | 37431 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL139452 | 37431 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL408886 | 219516 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 | 10.1021/jm00065a013 | ||||
22402420 | 55836 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 521 | 9 | 1 | 4 | 5.5 | COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL156129 | 55836 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 521 | 9 | 1 | 4 | 5.5 | COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
19939454 | 214336 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL94793 | 214336 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | ||
10003751 | 25610 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL128066 | 25610 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 447 | 5 | 1 | 2 | 5.5 | O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
5311348 | 107449 | 4 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm00077a001 | ||
CHEMBL292277 | 107449 | 4 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm00077a001 | ||
10455982 | 123425 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 8 | 1 | 2 | 5.6 | CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | ||
CHEMBL336991 | 123425 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 8 | 1 | 2 | 5.6 | CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/jm00077a001 | ||
10435148 | 124912 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 5.5 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
CHEMBL340778 | 124912 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 477 | 6 | 1 | 3 | 5.5 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
44303430 | 107811 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 541 | 12 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL294578 | 107811 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 541 | 12 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
44303878 | 105467 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.3 | CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL277567 | 105467 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 452 | 5 | 1 | 3 | 4.3 | CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C | 10.1016/S0960-894X(01)81007-6 | ||
22402433 | 56371 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 508 | 7 | 2 | 5 | 5.2 | COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL156587 | 56371 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 508 | 7 | 2 | 5 | 5.2 | COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
9851082 | 107797 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL294512 | 107797 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
44311543 | 110918 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL309455 | 110918 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
10410436 | 124582 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 4.4 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
CHEMBL340187 | 124582 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 430 | 5 | 1 | 3 | 4.4 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
18950592 | 23562 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | ||
CHEMBL124541 | 23562 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | ||
44309902 | 109894 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL307757 | 109894 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
44311663 | 210968 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL70796 | 210968 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44311569 | 211483 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL74113 | 211483 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44381714 | 65895 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169827 | 65895 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10416501 | 119187 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329759 | 119187 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
10349392 | 214829 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97557 | 214829 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | ||
44311607 | 210962 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL70770 | 210962 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44211673 | 66494 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL172376 | 66494 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | ||
44300826 | 205517 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL58291 | 205517 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | ||
10099830 | 115268 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL319955 | 115268 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | ||
44270278 | 105640 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL278983 | 105640 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
73349424 | 99406 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435833 | 99406 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
44379268 | 126832 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL350554 | 126832 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
10417431 | 115885 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | ||
CHEMBL321363 | 115885 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | ||
44322967 | 174721 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 712 | 15 | 1 | 10 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL431592 | 174721 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 712 | 15 | 1 | 10 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 | 10.1016/0960-894X(95)00477-B | ||
10032583 | 19121 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL1185398 | 19121 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL411487 | 19121 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | ||
3082918 | 101844 | 1 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
CHEMBL25528 | 101844 | 1 | None | - | 0 | Rat | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 340 | 7 | 1 | 3 | 4.2 | CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
60148656 | 99402 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435829 | 99402 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
44322233 | 118407 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 644 | 12 | 2 | 11 | 4.5 | CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL328480 | 118407 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 644 | 12 | 2 | 11 | 4.5 | CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
10047444 | 107123 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
CHEMBL289543 | 107123 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
10010047 | 214730 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97020 | 214730 | 0 | None | - | 0 | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | ||
164611656 | 191516 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1067 | 27 | 14 | 12 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4850726 | 191516 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1067 | 27 | 14 | 12 | 0.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1016/j.bmcl.2021.128086 | ||
44348408 | 120350 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | ||
CHEMBL332239 | 120350 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | ||
10055096 | 105061 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | ||
CHEMBL274712 | 105061 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | ||
10054188 | 214300 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
CHEMBL94582 | 214300 | 0 | None | - | 0 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
9939191 | 105722 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | ||
CHEMBL279629 | 105722 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | ||
CHEMBL97539 | 105722 | 1 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | ||
9829012 | 99331 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
CHEMBL24322 | 99331 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
9829012 | 99331 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL24322 | 99331 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | ||
44376781 | 63046 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL162859 | 63046 | 0 | None | - | 0 | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
9829012 | 99331 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | ||
CHEMBL24322 | 99331 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | ||
9895635 | 118800 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL328941 | 118800 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | ||
10484119 | 174887 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL432822 | 174887 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | ||
10075750 | 114335 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL318891 | 114335 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
44323291 | 213320 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 615 | 12 | 1 | 9 | 6.4 | CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL88600 | 213320 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 615 | 12 | 1 | 9 | 6.4 | CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
10095637 | 56741 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15689 | 56741 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
10009735 | 164984 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL408798 | 164984 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | ||
10004112 | 32302 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | ||
CHEMBL135089 | 32302 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | ||
44311683 | 112395 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL312301 | 112395 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311618 | 170116 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL419073 | 170116 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311581 | 174612 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL430792 | 174612 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311415 | 210864 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70161 | 210864 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311582 | 210987 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70868 | 210987 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44321790 | 213391 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 634 | 13 | 4 | 8 | 4.9 | C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL89052 | 213391 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 634 | 13 | 4 | 8 | 4.9 | C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44381656 | 127046 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL352458 | 127046 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
44330904 | 11118 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 698 | 19 | 1 | 8 | 7.3 | CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
CHEMBL101039 | 11118 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 698 | 19 | 1 | 8 | 7.3 | CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm00015a016 | ||
10373120 | 124379 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | ||
CHEMBL340078 | 124379 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | ||
15284887 | 172259 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 607 | 6 | 2 | 5 | 4.7 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O | 10.1016/S0960-894X(00)80690-3 | ||
CHEMBL424004 | 172259 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 607 | 6 | 2 | 5 | 4.7 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O | 10.1016/S0960-894X(00)80690-3 | ||
44381427 | 127051 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL352503 | 127051 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10259525 | 22391 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL122158 | 22391 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
9987614 | 175352 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL435792 | 175352 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44321823 | 212998 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 696 | 13 | 4 | 8 | 6.1 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL86617 | 212998 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 696 | 13 | 4 | 8 | 6.1 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 | 10.1016/0960-894X(95)00479-D | ||
19939753 | 210533 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL67921 | 210533 | 0 | None | - | 0 | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | ||
10100951 | 121822 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
CHEMBL334300 | 121822 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | ||
44371045 | 126589 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 4 | 6.0 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL348363 | 126589 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 4 | 6.0 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
10344854 | 64379 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
CHEMBL1668009 | 64379 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 5.2 | CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
10053595 | 109893 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL307756 | 109893 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44311638 | 109702 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306186 | 109702 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
44303230 | 207426 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL59957 | 207426 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
44303232 | 209494 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 434 | 8 | 1 | 6 | 4.8 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL61754 | 209494 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 434 | 8 | 1 | 6 | 4.8 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl | 10.1016/S0960-894X(01)80554-0 | ||
44311636 | 210908 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL70389 | 210908 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
15222103 | 211318 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL72819 | 211318 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44376746 | 126637 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL348758 | 126637 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
44303230 | 207426 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL59957 | 207426 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
11764669 | 73594 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL18606 | 73594 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
10233056 | 113936 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL316297 | 113936 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | ||
10009478 | 119249 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329858 | 119249 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | ||
10032361 | 119503 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL330463 | 119503 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | ||
10100723 | 214227 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL94176 | 214227 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
44303230 | 207426 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | ||
CHEMBL59957 | 207426 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | ||
11741658 | 25585 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 399 | 4 | 0 | 3 | 4.3 | COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL127844 | 25585 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 399 | 4 | 0 | 3 | 4.3 | COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
108185 | 8395 | 78 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | ||
586 | 8395 | 78 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | ||
CHEMBL907 | 8395 | 78 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | ||
1610 | 9126 | 95 | None | - | 4 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | ||
3941 | 9126 | 95 | None | - | 4 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | ||
3961 | 9126 | 95 | None | - | 4 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | ||
590 | 9126 | 95 | None | - | 4 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | ||
CHEMBL191 | 9126 | 95 | None | - | 4 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | ||
DB00678 | 9126 | 95 | None | - | 4 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | ||
183134 | 211623 | 17 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | ||
CHEMBL7550 | 211623 | 17 | None | - | 1 | Rat | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00050a002 | ||
44475943 | 195487 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 1508 | 12 | 8 | 32 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL504492 | 195487 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 1508 | 12 | 8 | 32 | 4.9 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
44309703 | 179333 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL448476 | 179333 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | ||
10417031 | 114163 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL317864 | 114163 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | ||
9986951 | 214546 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL95955 | 214546 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | ||
10416422 | 214778 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97295 | 214778 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
10416836 | 114681 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL319313 | 114681 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | ||
9888876 | 55764 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15606 | 55764 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | ||
73353934 | 99397 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435824 | 99397 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | ||
10372093 | 119539 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | ||
CHEMBL330533 | 119539 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | ||
44376822 | 126831 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL350493 | 126831 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
44274823 | 105851 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
CHEMBL280526 | 105851 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | ||
9830839 | 113708 | 0 | None | - | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL314812 | 113708 | 0 | None | - | 2 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | ||
44379183 | 127593 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL355708 | 127593 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
11758341 | 124061 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1021/jm00019a005 | ||
CHEMBL339544 | 124061 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1021/jm00019a005 | ||
10326942 | 119171 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL329693 | 119171 | 0 | None | - | 0 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | ||
10100074 | 119337 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
CHEMBL330007 | 119337 | 0 | None | - | 0 | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
44379184 | 64223 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL165541 | 64223 | 0 | None | - | 0 | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
44323351 | 113797 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL315401 | 113797 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 635 | 11 | 1 | 9 | 6.6 | CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
10394829 | 126138 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL344387 | 126138 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
10485202 | 126198 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL344811 | 126198 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
9873751 | 103195 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 614 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL261981 | 103195 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 614 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44323290 | 113677 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 587 | 10 | 1 | 9 | 5.6 | CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL314603 | 113677 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 587 | 10 | 1 | 9 | 5.6 | CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44381431 | 65275 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL168346 | 65275 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10078452 | 114055 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL317061 | 114055 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | ||
44377123 | 126753 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL349856 | 126753 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
10391038 | 123710 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1021/jm00019a005 | ||
CHEMBL338514 | 123710 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1021/jm00019a005 | ||
44309701 | 109963 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL308238 | 109963 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | ||
15230312 | 55688 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL155987 | 55688 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
164620345 | 192992 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4873167 | 192992 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
10054324 | 105129 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL275160 | 105129 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | ||
9908300 | 22318 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | ||
CHEMBL12190 | 22318 | 0 | None | - | 0 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 387 | 8 | 2 | 5 | 3.9 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1021/jm00053a013 | ||
73357016 | 99398 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435825 | 99398 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL408773 | 219510 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 | 10.1021/jm00065a013 | ||||
10462933 | 23654 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL125008 | 23654 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
9850834 | 161441 | 17 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | ||
CHEMBL39959 | 161441 | 17 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | ||
9874508 | 211459 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL73876 | 211459 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44210586 | 65786 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169221 | 65786 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10101690 | 123639 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
CHEMBL338137 | 123639 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | ||
10395394 | 38654 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL140708 | 38654 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44314780 | 109855 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL307430 | 109855 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
10010207 | 36968 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
CHEMBL139041 | 36968 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | ||
44315180 | 109673 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL305956 | 109673 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
19763341 | 68759 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 8 | 1 | 6 | 5.2 | CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00137a004 | ||
CHEMBL177435 | 68759 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 8 | 1 | 6 | 5.2 | CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00137a004 | ||
5311345 | 9795 | 46 | None | 10 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)80517-5 | ||
597 | 9795 | 46 | None | 10 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)80517-5 | ||
CHEMBL321820 | 9795 | 46 | None | 10 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)80517-5 | ||
5311345 | 9795 | 46 | None | 10 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)81122-7 | ||
597 | 9795 | 46 | None | 10 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL321820 | 9795 | 46 | None | 10 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(01)81122-7 | ||
9804437 | 124843 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.6 | O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL340467 | 124843 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 6 | 1 | 3 | 5.6 | O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
9915892 | 110395 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL308703 | 110395 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
10417351 | 214737 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97075 | 214737 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | ||
9895984 | 211528 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74476 | 211528 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | ||
9915892 | 110395 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
CHEMBL308703 | 110395 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | ||
19385644 | 105527 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL278061 | 105527 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | ||
44311429 | 211395 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL73369 | 211395 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | ||
10318033 | 125051 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 387 | 4 | 2 | 3 | 3.6 | O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL340933 | 125051 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 387 | 4 | 2 | 3 | 3.6 | O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44311342 | 108958 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL302760 | 108958 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
15222094 | 109751 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL306489 | 109751 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
15222101 | 165341 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL409170 | 165341 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44311688 | 110973 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL309820 | 110973 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
14952909 | 154854 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O | 10.1021/jm00108a043 | ||
CHEMBL39349 | 154854 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O | 10.1021/jm00108a043 | ||
73357018 | 99407 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435834 | 99407 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
19385598 | 105638 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL278955 | 105638 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | ||
44379291 | 127294 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL354535 | 127294 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
14952916 | 106922 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 | 10.1021/jm00108a043 | ||
CHEMBL287762 | 106922 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 425 | 10 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 | 10.1021/jm00108a043 | ||
44384872 | 66769 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL173455 | 66769 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL440063 | 220636 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
44315349 | 67164 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL17487 | 67164 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315350 | 111995 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL311484 | 111995 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
10259334 | 214817 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97500 | 214817 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | ||
114899 | 9794 | 15 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 10.1021/jm00137a004 | ||
596 | 9794 | 15 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 10.1021/jm00137a004 | ||
CHEMBL1188080 | 9794 | 15 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N | 10.1021/jm00137a004 | ||
5311348 | 107449 | 4 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm9504722 | ||
CHEMBL292277 | 107449 | 4 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 480 | 6 | 2 | 5 | 4.0 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N | 10.1021/jm9504722 | ||
44379086 | 63352 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL164174 | 63352 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
44311074 | 111677 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL311253 | 111677 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
9938088 | 109258 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL304022 | 109258 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1016/S0960-894X(01)80554-0 | ||
9851889 | 108851 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL302102 | 108851 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
44303883 | 209681 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL62744 | 209681 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
9938088 | 109258 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | ||
CHEMBL304022 | 109258 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 | 10.1021/jm00015a016 | ||
44382994 | 103679 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 933 | 25 | 7 | 10 | 5.8 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 10.1016/S0960-894X(00)80690-3 | ||
CHEMBL265790 | 103679 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 933 | 25 | 7 | 10 | 5.8 | Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 10.1016/S0960-894X(00)80690-3 | ||
CHEMBL384125 | 219096 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
44381657 | 65832 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169488 | 65832 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
10372550 | 171295 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL421478 | 171295 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
44314823 | 168665 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL415073 | 168665 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | ||
44314822 | 109726 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL306362 | 109726 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44303885 | 209682 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 538 | 12 | 1 | 4 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL62754 | 209682 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 538 | 12 | 1 | 4 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
10413312 | 124089 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.8 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | ||
CHEMBL339706 | 124089 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 491 | 6 | 1 | 3 | 5.8 | COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm00077a001 | ||
10344278 | 124961 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL340902 | 124961 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44323559 | 213790 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 628 | 10 | 1 | 9 | 4.9 | CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL91465 | 213790 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 628 | 10 | 1 | 9 | 4.9 | CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44311451 | 110879 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL309367 | 110879 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
18655106 | 207248 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL59854 | 207248 | 0 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | ||
15296723 | 55639 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 7 | 1 | 4 | 5.2 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL155938 | 55639 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 499 | 7 | 1 | 4 | 5.2 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 | 10.1016/S0960-894X(01)81122-7 | ||
14403498 | 107808 | 3 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm9504722 | ||
CHEMBL294558 | 107808 | 3 | None | - | 0 | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 495 | 7 | 1 | 5 | 4.4 | COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C | 10.1021/jm9504722 | ||
164612059 | 191280 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 1123 | 30 | 14 | 12 | 1.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4847398 | 191280 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 1123 | 30 | 14 | 12 | 1.6 | CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O | 10.1016/j.bmcl.2021.128086 | ||
44303614 | 207446 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 4.9 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL59974 | 207446 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 4.9 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | ||
15222070 | 109074 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL303426 | 109074 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44311648 | 211306 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL72721 | 211306 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
10349256 | 118233 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL327569 | 118233 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | ||
10461595 | 214899 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97964 | 214899 | 0 | None | - | 0 | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | ||
10254358 | 124273 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 475 | 6 | 0 | 3 | 5.5 | COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL340018 | 124273 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 475 | 6 | 0 | 3 | 5.5 | COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44311472 | 110569 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL308943 | 110569 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44377199 | 64193 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL165349 | 64193 | 0 | None | - | 0 | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
73353933 | 99394 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435821 | 99394 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
10078132 | 114028 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | ||
CHEMBL316904 | 114028 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | ||
10078048 | 113657 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL314514 | 113657 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | ||
10411441 | 58564 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15850 | 58564 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | ||
15230316 | 126870 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 522 | 7 | 1 | 6 | 5.3 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL350875 | 126870 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 522 | 7 | 1 | 6 | 5.3 | COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)81122-7 | ||
44348259 | 22804 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | ||
CHEMBL122367 | 22804 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | ||
1610 | 9126 | 95 | None | - | 4 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | ||
3941 | 9126 | 95 | None | - | 4 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | ||
3961 | 9126 | 95 | None | - | 4 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | ||
590 | 9126 | 95 | None | - | 4 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | ||
CHEMBL191 | 9126 | 95 | None | - | 4 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | ||
DB00678 | 9126 | 95 | None | - | 4 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | ||
1610 | 9126 | 95 | None | - | 4 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | ||
3941 | 9126 | 95 | None | - | 4 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | ||
3961 | 9126 | 95 | None | - | 4 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | ||
590 | 9126 | 95 | None | - | 4 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | ||
CHEMBL191 | 9126 | 95 | None | - | 4 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | ||
DB00678 | 9126 | 95 | None | - | 4 | Rat | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | ||
10393837 | 174723 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | ||
CHEMBL431619 | 174723 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | ||
44211672 | 164985 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | ||
CHEMBL408799 | 164985 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | ||
9892451 | 55514 | 23 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | ||
CHEMBL155836 | 55514 | 23 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1021/acs.jmedchem.9b01780 | ||
15296726 | 58645 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 9 | 2 | 5 | 5.1 | COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL158557 | 58645 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 551 | 9 | 2 | 5 | 5.1 | COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
18950598 | 22314 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | ||
CHEMBL121891 | 22314 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | ||
10483888 | 118232 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL327563 | 118232 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | ||
18950607 | 57192 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15729 | 57192 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | ||
9933755 | 61820 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL16165 | 61820 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | ||
73355475 | 99400 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435827 | 99400 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
9807029 | 209883 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL63998 | 209883 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
9807029 | 209883 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | ||
CHEMBL63998 | 209883 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | ||
73347892 | 99396 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
CHEMBL2435823 | 99396 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | ||
25135102 | 195649 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1495 | 12 | 10 | 32 | 3.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL507053 | 195649 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1495 | 12 | 10 | 32 | 3.6 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
10349801 | 114715 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL319353 | 114715 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | ||
19385586 | 56500 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15669 | 56500 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | ||
10414470 | 23901 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00019a005 | ||
CHEMBL125542 | 23901 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00019a005 | ||
44322176 | 213456 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 646 | 13 | 3 | 11 | 4.4 | CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL89463 | 213456 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 646 | 13 | 3 | 11 | 4.4 | CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
44381622 | 65795 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL169279 | 65795 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
44315078 | 211535 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74556 | 211535 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
19102815 | 214657 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
CHEMBL96554 | 214657 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | ||
44321775 | 113776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 588 | 13 | 4 | 8 | 4.4 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL315275 | 113776 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 588 | 13 | 4 | 8 | 4.4 | CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | ||
10439858 | 23633 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
CHEMBL124903 | 23633 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | ||
5311345 | 9795 | 46 | None | 10 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(00)80690-3 | ||
597 | 9795 | 46 | None | 10 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(00)80690-3 | ||
CHEMBL321820 | 9795 | 46 | None | 10 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1016/S0960-894X(00)80690-3 | ||
44381670 | 127262 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
CHEMBL354298 | 127262 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | ||
44315282 | 103399 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL263452 | 103399 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | ||
10344278 | 124961 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL340902 | 124961 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44303211 | 107374 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL291803 | 107374 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1016/S0960-894X(01)80554-0 | ||
44303404 | 206485 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 525 | 12 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL59331 | 206485 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 525 | 12 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL264450 | 217398 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CCSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
44311498 | 109707 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL306216 | 109707 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
15222092 | 110601 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL309165 | 110601 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44379182 | 64896 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL167662 | 64896 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
9961192 | 18138 | 43 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL1179743 | 18138 | 43 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97688 | 18138 | 43 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | ||
10417102 | 214225 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL94145 | 214225 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | ||
44303211 | 107374 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1021/jm9504722 | ||
CHEMBL291803 | 107374 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 8 | 2 | 6 | 5.8 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br | 10.1021/jm9504722 | ||
18950608 | 22443 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | ||
CHEMBL122224 | 22443 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | ||
44311568 | 104960 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL273992 | 104960 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
44270367 | 170002 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL418354 | 170002 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | ||
44377111 | 126662 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL349020 | 126662 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
44210830 | 64257 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | ||
CHEMBL165850 | 64257 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | ||
10054708 | 113931 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | ||
CHEMBL316273 | 113931 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | ||
44304163 | 209564 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 17 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
CHEMBL62157 | 209564 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 17 | 1 | 3 | 5.7 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | ||
10350378 | 214978 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | ||
CHEMBL98453 | 214978 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | ||
44574325 | 195529 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1521 | 12 | 8 | 32 | 4.8 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL505204 | 195529 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1521 | 12 | 8 | 32 | 4.8 | CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 | 10.1016/j.bmcl.2009.04.144 | ||
CHEMBL413034 | 219827 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
9874086 | 115890 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | ||
CHEMBL321367 | 115890 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | ||
19939756 | 11810 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
CHEMBL105199 | 11810 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
10349845 | 18134 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL1179731 | 18134 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | ||
CHEMBL97271 | 18134 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | ||
164627947 | 193164 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
CHEMBL4875696 | 193164 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | ||
10426066 | 107284 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 318 | 7 | 1 | 3 | 4.0 | CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
CHEMBL291114 | 107284 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 318 | 7 | 1 | 3 | 4.0 | CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl | 10.1021/jm00108a043 | ||
44311454 | 109722 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL306340 | 109722 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44311436 | 210967 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
CHEMBL70793 | 210967 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | ||
44303420 | 208522 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 12 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | ||
CHEMBL60661 | 208522 | 0 | None | - | 0 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 525 | 12 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 | 10.1016/S0960-894X(01)80554-0 | ||
44321804 | 112757 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 690 | 13 | 4 | 8 | 5.7 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL313073 | 112757 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 690 | 13 | 4 | 8 | 5.7 | CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL406290 | 219382 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O | 10.1021/jm00065a013 | ||||
15292111 | 211524 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL74442 | 211524 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
44315304 | 211789 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL76821 | 211789 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | ||
15230313 | 55388 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 446 | 6 | 1 | 4 | 4.3 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
CHEMBL155728 | 55388 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 446 | 6 | 1 | 4 | 4.3 | COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 | 10.1016/S0960-894X(01)81122-7 | ||
15292112 | 109725 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
CHEMBL306361 | 109725 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | ||
10368357 | 124049 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 491 | 7 | 1 | 3 | 5.5 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
CHEMBL339485 | 124049 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 491 | 7 | 1 | 3 | 5.5 | COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 | 10.1021/jm00077a001 | ||
10344278 | 124961 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
CHEMBL340902 | 124961 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 6 | 1 | 2 | 5.4 | O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 | 10.1021/jm00077a001 | ||
44311739 | 109384 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL304137 | 109384 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | ||
44311662 | 109458 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL304620 | 109458 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | ||
44311650 | 109978 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
CHEMBL308361 | 109978 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | ||
14952904 | 106940 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 396 | 9 | 2 | 5 | 4.8 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O | 10.1021/jm00108a043 | ||
CHEMBL287936 | 106940 | 0 | None | - | 0 | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 396 | 9 | 2 | 5 | 4.8 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O | 10.1021/jm00108a043 | ||
44309704 | 211057 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | ||
CHEMBL71253 | 211057 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | ||
44300798 | 205734 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | ||
CHEMBL58499 | 205734 | 0 | None | - | 0 | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | ||
9805344 | 105816 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL280290 | 105816 | 0 | None | - | 0 | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | ||
10372718 | 115334 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | ||
CHEMBL320222 | 115334 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | ||
9809280 | 211751 | 10 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL76525 | 211751 | 10 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | ||
CHEMBL80370 | 211751 | 10 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1016/0960-894X(95)00479-D | ||
9809280 | 211751 | 10 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1021/jm9504722 | ||
CHEMBL76525 | 211751 | 10 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1021/jm9504722 | ||
CHEMBL80370 | 211751 | 10 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 4.8 | CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 | 10.1021/jm9504722 | ||
19385623 | 57209 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | ||
CHEMBL15730 | 57209 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | ||
44335530 | 114286 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
CHEMBL318605 | 114286 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | ||
44323292 | 170581 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 615 | 12 | 1 | 9 | 6.2 | CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL420607 | 170581 | 0 | None | - | 0 | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 615 | 12 | 1 | 9 | 6.2 | CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44323363 | 118383 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 558 | 10 | 2 | 8 | 4.5 | CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
CHEMBL328340 | 118383 | 0 | None | - | 0 | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 558 | 10 | 2 | 8 | 4.5 | CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00477-B | ||
44379185 | 64328 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
CHEMBL166428 | 64328 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | ||
19742811 | 64195 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
CHEMBL165354 | 64195 | 0 | None | - | 0 | Rat | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | ||
56661223 | 70026 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
CHEMBL1791308 | 70026 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
CHEMBL2392353 | 217193 | 6 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | None | None | None | None | 10.1016/j.ejmech.2013.01.044 | ||||
10079601 | 219310 | 14 | None | 4 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | ||||
CHEMBL404594 | 219310 | 14 | None | 4 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | ||||
10079601 | 219310 | 14 | None | 4 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.bmcl.2015.10.084 | ||||
CHEMBL404594 | 219310 | 14 | None | 4 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.bmcl.2015.10.084 | ||||
CHEMBL938 | 222686 | 28 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | ||||
CHEMBL216061 | 216095 | 15 | None | -1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | ||||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm050280z | ||||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | None | None | None | None | 10.1016/j.bmcl.2015.10.084 | ||||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030921v | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030921v | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030921v | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030921v | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030921v | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030921v | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm030921v | ||||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0491492 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0491492 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0491492 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0491492 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0491492 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0491492 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0491492 | ||||
56661223 | 70026 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
CHEMBL1791308 | 70026 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0613469 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0613469 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0613469 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0613469 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0613469 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0613469 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm0613469 | ||||
CHEMBL938 | 222686 | 28 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/ml500278g | ||||
CHEMBL938 | 222686 | 28 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | None | None | None | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmcl.2015.10.084 | ||||
6918 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2010.03.064 | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2010.03.064 | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2010.03.064 | ||
6918 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | ||
6918 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/ml500278g | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/ml500278g | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/ml500278g | ||
6918 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2015.10.084 | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2015.10.084 | ||
6918 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/jm049715t | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/jm049715t | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/jm049715t | ||
11317806 | 130420 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 489 | 10 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 | 10.1021/jm049715t | ||
CHEMBL361927 | 130420 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 489 | 10 | 1 | 7 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 | 10.1021/jm049715t | ||
11994291 | 87503 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 485 | 12 | 1 | 7 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL215160 | 87503 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 485 | 12 | 1 | 7 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
11994289 | 89252 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL217673 | 89252 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm051222g | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm051222g | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm051222g | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm051222g | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm051222g | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm051222g | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm051222g | ||||
CHEMBL404996 | 219318 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CCSC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm030921v | ||||
CHEMBL3350599 | 218260 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | ||||
11994289 | 89252 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
CHEMBL217673 | 89252 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
11994289 | 89252 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL217673 | 89252 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL268815 | 217545 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm051222g | ||||
10463891 | 103689 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
CHEMBL265881 | 103689 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
CHEMBL268815 | 217545 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm0491492 | ||||
CHEMBL424755 | 220103 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O | 10.1021/jm0613469 | ||||
44398242 | 73990 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | ||
CHEMBL187880 | 73990 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | ||
10163396 | 88353 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 489 | 12 | 1 | 7 | 4.5 | CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL216250 | 88353 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 489 | 12 | 1 | 7 | 4.5 | CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL5286105 | 201110 | 0 | None | - | 1 | Rat | 9.0 | pKi | = | 9 | Binding | ChEMBL | 1073 | 26 | 13 | 14 | -1.2 | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H]1SC[C@H]2C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | ||
168283461 | 197762 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 462 | 10 | 1 | 8 | 4.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5186237 | 197762 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 462 | 10 | 1 | 8 | 4.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | ||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049651m | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049651m | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049651m | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049651m | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049651m | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049651m | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm049651m | ||||
CHEMBL5274111 | 200574 | 0 | None | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1060 | 30 | 14 | 13 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | ||
168273584 | 196992 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 503 | 8 | 1 | 10 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5174659 | 196992 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 503 | 8 | 1 | 10 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL268815 | 217545 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm049651m | ||||
9850834 | 161441 | 17 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
CHEMBL39959 | 161441 | 17 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
16087342 | 148491 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | ||
CHEMBL385706 | 148491 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1149 | 28 | 13 | 14 | 0.8 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | ||
11564291 | 173873 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1008 | 26 | 12 | 12 | -0.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
CHEMBL428986 | 173873 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1008 | 26 | 12 | 12 | -0.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
10160913 | 148585 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL386269 | 148585 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
11766283 | 78355 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 909 | 23 | 11 | 11 | -0.2 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
CHEMBL196316 | 78355 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 909 | 23 | 11 | 11 | -0.2 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
168270996 | 196838 | 0 | None | 64 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5172324 | 196838 | 0 | None | 64 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
168291545 | 198769 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 597 | 10 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5201369 | 198769 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 597 | 10 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 | 10.1016/j.bmc.2022.116804 | ||
162660565 | 188101 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4762752 | 188101 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL426885 | 220130 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)O | 10.1021/jm0613469 | ||||
56657702 | 70027 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
CHEMBL1791309 | 70027 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
168290795 | 198726 | 0 | None | 33 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5200734 | 198726 | 0 | None | 33 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
168292515 | 198818 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5202149 | 198818 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 | 10.1016/j.bmc.2022.116804 | ||
118725967 | 123976 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | ||
CHEMBL3394207 | 123976 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | ||
118725967 | 123976 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL3394207 | 123976 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | ||
168274956 | 197117 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 573 | 10 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5176607 | 197117 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 573 | 10 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
10227337 | 88431 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL216361 | 88431 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
168296606 | 199227 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 587 | 11 | 1 | 6 | 8.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5208437 | 199227 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 587 | 11 | 1 | 6 | 8.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
145963801 | 170840 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4209214 | 170840 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
11365721 | 105443 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 640 | 13 | 1 | 10 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL277388 | 105443 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 640 | 13 | 1 | 10 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1021/jm031031i | ||
168287840 | 198085 | 0 | None | 32 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5191241 | 198085 | 0 | None | 32 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
145978135 | 170668 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 9 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4207027 | 170668 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 473 | 9 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | ||
168295859 | 199064 | 0 | None | -50 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5205969 | 199064 | 0 | None | -50 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | ||
168288075 | 198441 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 595 | 12 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5196244 | 198441 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 595 | 12 | 1 | 6 | 7.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
11994292 | 88761 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 471 | 10 | 1 | 7 | 4.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL216515 | 88761 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 471 | 10 | 1 | 7 | 4.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
168285844 | 198348 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 8 | 1 | 8 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5194914 | 198348 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 8 | 1 | 8 | 4.2 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | ||
44420775 | 144662 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1021/jm0613469 | ||
CHEMBL376286 | 144662 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1021/jm0613469 | ||
145965121 | 171205 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4213607 | 171205 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | ||
11296725 | 107150 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 652 | 13 | 2 | 9 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL289803 | 107150 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 652 | 13 | 2 | 9 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | ||
9830680 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | ||
CHEMBL292150 | 107419 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm990504b | ||
162657895 | 187838 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 545 | 12 | 1 | 8 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4759641 | 187838 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 545 | 12 | 1 | 8 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
56964910 | 84219 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/ml500278g | ||
CHEMBL2086892 | 84219 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1021/ml500278g | ||
56964910 | 84219 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL2086892 | 84219 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2015.10.084 | ||
162675267 | 190136 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 501 | 8 | 1 | 7 | 4.8 | CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4797684 | 190136 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 501 | 8 | 1 | 7 | 4.8 | CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
11764788 | 107635 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | ||
CHEMBL293501 | 107635 | 0 | None | - | 1 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm990504b | ||
158303357 | 199011 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 532 | 10 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5205106 | 199011 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 532 | 10 | 1 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
166492461 | 198591 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 474 | 8 | 1 | 8 | 4.2 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5198482 | 198591 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 474 | 8 | 1 | 8 | 4.2 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | ||
145977406 | 170627 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 487 | 8 | 1 | 7 | 5.2 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4206507 | 170627 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 487 | 8 | 1 | 7 | 5.2 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 | 10.1016/j.bmcl.2017.11.042 | ||
73213176 | 111478 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 454 | 9 | 2 | 6 | 2.6 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3105392 | 111478 | 0 | None | - | 1 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 454 | 9 | 2 | 6 | 2.6 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/j.bmcl.2013.12.040 | ||
11995658 | 88913 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 364 | 6 | 1 | 6 | 4.0 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 | 10.1021/jm0606185 | ||
CHEMBL216746 | 88913 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 364 | 6 | 1 | 6 | 4.0 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 | 10.1021/jm0606185 | ||
168274734 | 197445 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 561 | 12 | 1 | 6 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5181652 | 197445 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 561 | 12 | 1 | 6 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
166492455 | 198188 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 4.4 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5192639 | 198188 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 476 | 7 | 1 | 8 | 4.4 | CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | ||
3936 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | ||
6603900 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | ||
CHEMBL288174 | 8991 | 35 | None | -2 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | ||
11994290 | 87175 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 4.4 | CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 | 10.1021/jm0606185 | ||
CHEMBL214525 | 87175 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 441 | 9 | 1 | 6 | 4.4 | CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 | 10.1021/jm0606185 | ||
CHEMBL268815 | 217545 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | None | None | None | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm030921v | ||||
10031067 | 107128 | 4 | None | -2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
CHEMBL289614 | 107128 | 4 | None | -2 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.5b00982 | ||
CHEMBL216331 | 216102 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | None | None | None | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm049651m | ||||
56657702 | 70027 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
CHEMBL1791309 | 70027 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm0491492 | ||
168277309 | 197007 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 448 | 8 | 1 | 8 | 3.7 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5174923 | 197007 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 448 | 8 | 1 | 8 | 3.7 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | ||
3936 | 8991 | 35 | None | -2 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | ||
6603900 | 8991 | 35 | None | -2 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | ||
CHEMBL288174 | 8991 | 35 | None | -2 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm031031i | ||
44400670 | 165671 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 993 | 23 | 12 | 13 | -0.7 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
CHEMBL409528 | 165671 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 993 | 23 | 12 | 13 | -0.7 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
3936 | 8991 | 35 | None | -2 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | ||
6603900 | 8991 | 35 | None | -2 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | ||
CHEMBL288174 | 8991 | 35 | None | -2 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm049715t | ||
168277868 | 197256 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 476 | 10 | 1 | 8 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5178914 | 197256 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 476 | 10 | 1 | 8 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2022.116790 | ||
145978497 | 170433 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 489 | 10 | 1 | 7 | 5.3 | CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4204342 | 170433 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 489 | 10 | 1 | 7 | 5.3 | CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
145972310 | 171346 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 474 | 9 | 1 | 6 | 4.6 | CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4215292 | 171346 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 474 | 9 | 1 | 6 | 4.6 | CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
45102601 | 176350 | 12 | None | -1995 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | ||
CHEMBL4435800 | 176350 | 12 | None | -1995 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | ||
162651258 | 187114 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 545 | 13 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4751226 | 187114 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 545 | 13 | 1 | 8 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 | 10.1016/j.bmc.2020.115859 | ||
166492466 | 198721 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 8 | 1 | 8 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5200682 | 198721 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 476 | 8 | 1 | 8 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
56964910 | 84219 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL2086892 | 84219 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | ||
56964910 | 84219 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL2086892 | 84219 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
145967796 | 171612 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4218765 | 171612 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1016/j.bmcl.2017.11.042 | ||
67132863 | 84222 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 503 | 11 | 1 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL2086910 | 84222 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 503 | 11 | 1 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 | 10.1016/j.bmc.2020.115859 | ||
145976243 | 170305 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 11 | 1 | 6 | 5.2 | CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4202730 | 170305 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 473 | 11 | 1 | 6 | 5.2 | CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
163408877 | 197478 | 3 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 7 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5182186 | 197478 | 3 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 490 | 7 | 1 | 8 | 4.6 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
168277087 | 197265 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 505 | 10 | 1 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5179052 | 197265 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 505 | 10 | 1 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
145969149 | 171548 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 9 | 1 | 7 | 4.7 | CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4217991 | 171548 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 461 | 9 | 1 | 7 | 4.7 | CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
73213178 | 111479 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 483 | 10 | 3 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3105394 | 111479 | 0 | None | - | 1 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 483 | 10 | 3 | 6 | 2.4 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2013.12.040 | ||
10057017 | 168606 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm030921v | ||
CHEMBL414478 | 168606 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm030921v | ||
10057017 | 168606 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm0491492 | ||
CHEMBL414478 | 168606 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1093 | 26 | 13 | 14 | -0.6 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 | 10.1021/jm0491492 | ||
168272246 | 197271 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 10 | 1 | 8 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5179119 | 197271 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 477 | 10 | 1 | 8 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 | 10.1016/j.bmc.2022.116790 | ||
10196520 | 74418 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 553 | 11 | 1 | 7 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1021/jm049715t | ||
CHEMBL190577 | 74418 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 553 | 11 | 1 | 7 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1021/jm049715t | ||
6918 | 7815 | 35 | None | -3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116804 | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116804 | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2022.116804 | ||
44398381 | 74380 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | ||
CHEMBL190286 | 74380 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 599 | 11 | 6 | 8 | -0.2 | CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 | 10.1021/jm049651m | ||
CHEMBL5286767 | 201134 | 0 | None | - | 1 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1073 | 26 | 13 | 14 | -1.2 | CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CS[C@@H]21 | 10.1016/j.bmcl.2022.128983 | ||
10054827 | 170917 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | ||
CHEMBL42101 | 170917 | 0 | None | - | 1 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 634 | 11 | 1 | 8 | 6.8 | CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00037a014 | ||
145978684 | 170340 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 4.5 | CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4203099 | 170340 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 4.5 | CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
145974498 | 171505 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4217484 | 171505 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 447 | 8 | 1 | 7 | 4.3 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
168287782 | 198603 | 0 | None | 22 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5198739 | 198603 | 0 | None | 22 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
10277322 | 148566 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL386172 | 148566 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
11274375 | 107238 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 804 | 16 | 1 | 9 | 9.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL290708 | 107238 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 804 | 16 | 1 | 9 | 9.4 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
163409135 | 196962 | 3 | None | -37 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5174180 | 196962 | 3 | None | -37 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | ||
11216369 | 107147 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 742 | 15 | 1 | 9 | 8.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL289775 | 107147 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 742 | 15 | 1 | 9 | 8.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
11994293 | 89076 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 4.9 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL217208 | 89076 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 4.9 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
145976532 | 170385 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 443 | 8 | 1 | 6 | 4.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4203624 | 170385 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 443 | 8 | 1 | 6 | 4.1 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 | 10.1016/j.bmcl.2017.11.042 | ||
168279676 | 197908 | 0 | None | 11 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5188126 | 197908 | 0 | None | 11 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
166492421 | 197404 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 11 | 1 | 10 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5181087 | 197404 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 545 | 11 | 1 | 10 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | ||
10116410 | 148297 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL384577 | 148297 | 1 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 4.9 | CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
11445913 | 140400 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 908 | 19 | 10 | 12 | 0.3 | C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
CHEMBL371395 | 140400 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 908 | 19 | 10 | 12 | 0.3 | C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
16124929 | 90220 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 | 10.1021/jm0613469 | ||
CHEMBL219840 | 90220 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 7 | 2 | 4 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 | 10.1021/jm0613469 | ||
166492441 | 198284 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5193845 | 198284 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
162666037 | 189091 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 559 | 14 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4784233 | 189091 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 559 | 14 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 | 10.1016/j.bmc.2020.115859 | ||
8374 | 9696 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | ||
9937291 | 9696 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | ||
CHEMBL34124 | 9696 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | ||
DB16266 | 9696 | 42 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1016/j.bmcl.2015.10.084 | ||
145964638 | 171162 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 489 | 11 | 1 | 7 | 5.5 | CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4213069 | 171162 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 489 | 11 | 1 | 7 | 5.5 | CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
168274602 | 197155 | 0 | None | 97 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5177359 | 197155 | 0 | None | 97 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
9806878 | 134298 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 525 | 10 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1021/jm049715t | ||
CHEMBL366210 | 134298 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 525 | 10 | 1 | 7 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 | 10.1021/jm049715t | ||
11995655 | 148275 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 488 | 10 | 1 | 6 | 5.0 | CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL384462 | 148275 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 488 | 10 | 1 | 6 | 5.0 | CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
44212339 | 211815 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
CHEMBL77029 | 211815 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
168297670 | 199157 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 615 | 10 | 1 | 6 | 7.8 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5207511 | 199157 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 615 | 10 | 1 | 6 | 7.8 | CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | ||
11181498 | 107285 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 680 | 14 | 1 | 9 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL291124 | 107285 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 680 | 14 | 1 | 9 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | ||
16087341 | 103656 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | ||
CHEMBL265613 | 103656 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1050 | 25 | 12 | 13 | 0.7 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | ||
16124928 | 90219 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 7 | 3 | 3 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 | 10.1021/jm0613469 | ||
CHEMBL219839 | 90219 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 349 | 7 | 3 | 3 | 2.4 | O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 | 10.1021/jm0613469 | ||
11180576 | 107088 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 566 | 11 | 1 | 7 | 6.6 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
CHEMBL289306 | 107088 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 566 | 11 | 1 | 7 | 6.6 | CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm031031i | ||
145972980 | 171273 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 433 | 7 | 1 | 7 | 3.9 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4214477 | 171273 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 433 | 7 | 1 | 7 | 3.9 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
145972801 | 171381 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4215828 | 171381 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 474 | 10 | 2 | 6 | 4.6 | CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
166492420 | 199037 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 559 | 11 | 1 | 10 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5205556 | 199037 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 559 | 11 | 1 | 10 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | ||
11722069 | 77342 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 895 | 22 | 11 | 11 | 0.1 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
CHEMBL194864 | 77342 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 895 | 22 | 11 | 11 | 0.1 | NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
73213175 | 111477 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 397 | 8 | 2 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3105391 | 111477 | 0 | None | - | 1 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 397 | 8 | 2 | 6 | 3.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 | 10.1016/j.bmcl.2013.12.040 | ||
166492452 | 197554 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 502 | 11 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5183386 | 197554 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 502 | 11 | 1 | 8 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | ||
145966800 | 170805 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 5.1 | CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4208670 | 170805 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 475 | 9 | 1 | 7 | 5.1 | CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
11366289 | 174792 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 784 | 18 | 1 | 9 | 9.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL432095 | 174792 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 784 | 18 | 1 | 9 | 9.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 | 10.1021/jm031031i | ||
168283187 | 197996 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 639 | 11 | 1 | 6 | 8.4 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5189691 | 197996 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 639 | 11 | 1 | 6 | 8.4 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
10396262 | 122212 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1022 | 27 | 12 | 12 | 0.3 | CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | ||
CHEMBL3350600 | 122212 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1022 | 27 | 12 | 12 | 0.3 | CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm050280z | ||
16125001 | 113208 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3105395 | 113208 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3139603 | 113208 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 315 | 7 | 2 | 4 | 2.2 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O | 10.1016/j.bmcl.2013.12.040 | ||
11331641 | 107078 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 742 | 15 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL289211 | 107078 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 742 | 15 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 | 10.1021/jm031031i | ||
67133138 | 84223 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 531 | 12 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL2086911 | 84223 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 531 | 12 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 | 10.1016/j.bmc.2020.115859 | ||
10742620 | 64376 | 0 | None | -16 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
CHEMBL1668003 | 64376 | 0 | None | -16 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
163409136 | 197681 | 3 | None | -18 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5185088 | 197681 | 3 | None | -18 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | ||
145965943 | 170983 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4210874 | 170983 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 477 | 10 | 1 | 8 | 3.9 | COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 | 10.1016/j.bmcl.2017.11.042 | ||
131590 | 27475 | 44 | None | -16 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | ||
CHEMBL130896 | 27475 | 44 | None | -16 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | ||
10276878 | 87197 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 469 | 11 | 1 | 6 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL214592 | 87197 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 469 | 11 | 1 | 6 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
10140383 | 89165 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 11 | 1 | 7 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL217249 | 89165 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 11 | 1 | 7 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
168271055 | 196717 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 588 | 11 | 1 | 8 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5170220 | 196717 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 588 | 11 | 1 | 8 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
168272577 | 197134 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5176951 | 197134 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 561 | 10 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
168277414 | 197242 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 517 | 8 | 1 | 10 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5178751 | 197242 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 517 | 8 | 1 | 10 | 4.4 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 | 10.1016/j.bmc.2022.116790 | ||
166492465 | 197326 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 518 | 11 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5179875 | 197326 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 518 | 11 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
162650706 | 186817 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4747530 | 186817 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 | 10.1016/j.bmc.2020.115859 | ||
16087340 | 172716 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 912 | 21 | 10 | 11 | 1.2 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | ||
CHEMBL425077 | 172716 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 912 | 21 | 10 | 11 | 1.2 | CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm051222g | ||
168292360 | 198656 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 581 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5199606 | 198656 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 581 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
168278021 | 196972 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5174301 | 196972 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 651 | 10 | 1 | 6 | 8.0 | CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 | 10.1016/j.bmc.2022.116804 | ||
11994156 | 88904 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 10 | 1 | 7 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL216688 | 88904 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 461 | 10 | 1 | 7 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
162663560 | 188717 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 559 | 11 | 1 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4779819 | 188717 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 559 | 11 | 1 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
56678310 | 70025 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1034 | 25 | 11 | 12 | 1.0 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm030921v | ||
CHEMBL1791259 | 70025 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1034 | 25 | 11 | 12 | 1.0 | CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O | 10.1021/jm030921v | ||
10140382 | 148654 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1021/jm0606185 | ||
CHEMBL386671 | 148654 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 475 | 7 | 1 | 7 | 5.1 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 | 10.1021/jm0606185 | ||
9891811 | 126520 | 1 | None | -8128 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | ||
CHEMBL347703 | 126520 | 1 | None | -8128 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | ||
CHEMBL4524047 | 126520 | 1 | None | -8128 | 2 | Rat | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 475 | 8 | 2 | 7 | 4.8 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 | 10.1016/S0960-894X(01)81137-9 | ||
10289461 | 74542 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 526 | 10 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 | 10.1021/jm049715t | ||
CHEMBL190811 | 74542 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 526 | 10 | 1 | 8 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 | 10.1021/jm049715t | ||
162663467 | 188731 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 9 | 1 | 8 | 5.4 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4779945 | 188731 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 531 | 9 | 1 | 8 | 5.4 | CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
11316477 | 74869 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 | 10.1021/jm049715t | ||
CHEMBL191468 | 74869 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 9 | 1 | 6 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 | 10.1021/jm049715t | ||
163848227 | 196890 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 518 | 10 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5173054 | 196890 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 518 | 10 | 1 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 | 10.1016/j.bmc.2022.116790 | ||
145965035 | 171030 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 529 | 10 | 1 | 7 | 5.6 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmcl.2017.11.042 | ||
CHEMBL4211391 | 171030 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 529 | 10 | 1 | 7 | 5.6 | CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmcl.2017.11.042 | ||
132404 | 126564 | 14 | None | -36 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | ||
CHEMBL348126 | 126564 | 14 | None | -36 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | ||
10161763 | 87502 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1021/jm0606185 | ||
CHEMBL215159 | 87502 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 461 | 8 | 1 | 7 | 4.7 | CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 | 10.1021/jm0606185 | ||
10300357 | 148492 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 4.3 | CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL385714 | 148492 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 4.3 | CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
4189 | 213701 | 96 | None | -38 | 34 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL1559 | 213701 | 96 | None | -38 | 34 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
CHEMBL91 | 213701 | 96 | None | -38 | 34 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | nan | ||
10182998 | 148662 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 4.7 | CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL386718 | 148662 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 4.7 | CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
132840 | 112266 | 22 | None | -3311 | 3 | Rat | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | ||
CHEMBL312104 | 112266 | 22 | None | -3311 | 3 | Rat | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00041a016 | ||
11239632 | 106927 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 748 | 15 | 1 | 10 | 8.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL287829 | 106927 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 748 | 15 | 1 | 10 | 8.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
118725969 | 123977 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | ||
CHEMBL3394209 | 123977 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 | 10.1021/acs.jmedchem.5b00982 | ||
11251114 | 165965 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 714 | 14 | 2 | 9 | 7.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
CHEMBL409843 | 165965 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 714 | 14 | 2 | 9 | 7.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 | 10.1021/jm031031i | ||
73213179 | 111482 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 511 | 10 | 3 | 6 | 3.0 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3105465 | 111482 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 511 | 10 | 3 | 6 | 3.0 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C | 10.1016/j.bmcl.2013.12.040 | ||
10205901 | 89288 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 477 | 11 | 1 | 8 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
CHEMBL217752 | 89288 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 477 | 11 | 1 | 8 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1021/jm0606185 | ||
168294859 | 199055 | 0 | None | 19 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5205769 | 199055 | 0 | None | 19 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
44400615 | 163396 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1007 | 22 | 11 | 13 | 0.4 | CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
CHEMBL406907 | 163396 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1007 | 22 | 11 | 13 | 0.4 | CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 | 10.1021/jm0491492 | ||
162670036 | 189435 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 517 | 8 | 1 | 8 | 5.0 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
CHEMBL4788892 | 189435 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 517 | 8 | 1 | 8 | 5.0 | COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 | 10.1016/j.bmc.2020.115859 | ||
168275495 | 197250 | 0 | None | 66 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
CHEMBL5178838 | 197250 | 0 | None | 66 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | ||
11672486 | 105287 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
CHEMBL276163 | 105287 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 994 | 25 | 12 | 12 | 0.3 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 | 10.1021/jm050280z | ||
166492458 | 198353 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 516 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | ||
CHEMBL5195051 | 198353 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 516 | 11 | 1 | 8 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 | 10.1016/j.bmc.2022.116790 | ||
6918 | 7815 | 35 | None | -3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2013.12.040 | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmcl.2013.12.040 | ||
73213180 | 111483 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 499 | 11 | 3 | 7 | 2.1 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3105466 | 111483 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 499 | 11 | 3 | 7 | 2.1 | CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 | 10.1016/j.bmcl.2013.12.040 | ||
73213252 | 111484 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 434 | 11 | 2 | 6 | 2.3 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC | 10.1016/j.bmcl.2013.12.040 | ||
CHEMBL3105467 | 111484 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 434 | 11 | 2 | 6 | 2.3 | CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC | 10.1016/j.bmcl.2013.12.040 | ||
1610 | 9126 | 95 | None | - | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
3941 | 9126 | 95 | None | - | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
3961 | 9126 | 95 | None | - | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
590 | 9126 | 95 | None | - | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
CHEMBL191 | 9126 | 95 | None | - | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
DB00678 | 9126 | 95 | None | - | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
1037 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | ||
3940 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | ||
5281037 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | ||
588 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | ||
CHEMBL813 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | ||
DB00876 | 8359 | 69 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | ||
2583 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | ||
592 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | ||
65999 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | ||
CHEMBL1017 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | ||
DB00966 | 10548 | 118 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | ||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 8.0 | pKd | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
16133225 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 7850406 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
172198 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 7850406 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
2504 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 7850406 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
45266664 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 7850406 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
5272 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 7850406 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
CHEMBL408403 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 7850406 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
DB11842 | 7207 | 52 | None | 1 | 5 | Human | 10.2 | pKd | = | 10.2 | Binding | Guide to Pharmacology | None | None | None | None | 7850406 | ||||
44299731 | 7208 | 0 | None | - | 1 | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
44299731 | 7208 | 0 | None | - | 1 | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | None | None | None | None | 8242249 | ||||
585 | 7208 | 0 | None | - | 1 | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
585 | 7208 | 0 | None | - | 1 | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | None | None | None | None | 8242249 | ||||
CHEMBL56448 | 7208 | 0 | None | - | 1 | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
CHEMBL56448 | 7208 | 0 | None | - | 1 | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | None | None | None | None | 8242249 | ||||
123794 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 1764088 | ||||
123794 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
3944 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 1764088 | ||||
3944 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
594 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 1764088 | ||||
594 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
CHEMBL1885579 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 1764088 | ||||
CHEMBL1885579 | 7680 | 46 | None | 67608 | 2 | Human | 10.6 | pKd | = | 10.6 | Binding | Guide to Pharmacology | None | None | None | None | 2775266 | ||||
5311345 | 9795 | 46 | None | 10 | 2 | Human | 9.0 | pKd | = | 9.0 | Binding | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 1709220 | ||
5311345 | 9795 | 46 | None | 10 | 2 | Human | 9.0 | pKd | = | 9.0 | Binding | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 2402226 | ||
597 | 9795 | 46 | None | 10 | 2 | Human | 9.0 | pKd | = | 9.0 | Binding | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 1709220 | ||
597 | 9795 | 46 | None | 10 | 2 | Human | 9.0 | pKd | = | 9.0 | Binding | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 2402226 | ||
CHEMBL321820 | 9795 | 46 | None | 10 | 2 | Human | 9.0 | pKd | = | 9.0 | Binding | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 1709220 | ||
CHEMBL321820 | 9795 | 46 | None | 10 | 2 | Human | 9.0 | pKd | = | 9.0 | Binding | Guide to Pharmacology | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 2402226 | ||
595 | 9770 | 0 | None | - | 1 | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 2194459 | ||||
4189 | 213701 | 96 | None | -38 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
CHEMBL1559 | 213701 | 96 | None | -38 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
CHEMBL91 | 213701 | 96 | None | -38 | 34 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 414 | 6 | 0 | 3 | 6.5 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | None | ||
36736 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
598 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
6324663 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
CHEMBL356431 | 10247 | 0 | None | -5 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | None | None | None | None | None | ||||
6893 | 9642 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 18207609 | ||||
9987879 | 9642 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 18207609 | ||||
6894 | 7206 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 21464395 | ||||
91691124 | 7206 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | None | None | None | None | 21464395 | ||||
6918 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 15537354 | ||
9804984 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 15537354 | ||
CHEMBL189568 | 7815 | 35 | None | -3 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 15537354 | ||
11931 | 7851 | 0 | None | 10 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | ||
126456406 | 7851 | 0 | None | 10 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | ||
11930 | 7806 | 0 | None | 537 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | ||
15780052 | 7806 | 0 | None | 537 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | ||
CHEMBL289472 | 7806 | 0 | None | 537 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 |