Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
1481 8847 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 8847 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 8847 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 8847 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 8847 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 8847 116 None -109647 6 Human 4.0 pAC50 = 4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
40466887 212654 66 None - 1 Human 5.4 pAC50 = 5.4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
5362124 212654 66 None - 1 Human 5.4 pAC50 = 5.4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
CHEMBL838 212654 66 None - 1 Human 5.4 pAC50 = 5.4 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
1610 9126 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 9126 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 9126 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 9126 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 9126 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 9126 95 None -954 11 Human 6.3 pAC50 = 6.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
158781 50940 98 None -95499 3 Human 4.3 pAC50 = 4.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
CHEMBL1516 50940 98 None -95499 3 Human 4.3 pAC50 = 4.3 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 446 8 3 7 3.7 CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1038/s41467-023-40064-9
1610 9126 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 9126 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 9126 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 9126 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 9126 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 9126 95 None -954 11 Human 4.2 pAC50 = 4.2 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
1610 9126 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3941 9126 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
3961 9126 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
590 9126 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
CHEMBL191 9126 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
DB00678 9126 95 None -954 11 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1038/s41467-023-40064-9
130881 9695 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
1985 9695 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
591 9695 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
CHEMBL1200692 9695 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
DB00275 9695 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
nan 9695 108 None -23442 3 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 558 10 2 11 4.2 CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C 10.1038/s41467-023-40064-9
40466887 212654 66 None - 1 Human 5.1 pAC50 = 5.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
5362124 212654 66 None - 1 Human 5.1 pAC50 = 5.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
CHEMBL838 212654 66 None - 1 Human 5.1 pAC50 = 5.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 424 9 2 5 2.6 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(=O)O)C1=O 10.1038/s41467-023-40064-9
2541 7573 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
587 7573 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
6907 7573 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1016 7573 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB00796 7573 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
DB13919 7573 120 None -45708 10 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1038/s41467-023-40064-9
3033 36925 102 None -8709 4 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 295 4 2 2 4.4 O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
CHEMBL1034 36925 102 None -8709 4 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 295 4 2 2 4.4 O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
CHEMBL139 36925 102 None -8709 4 Human 4.1 pAC50 = 4.1 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 295 4 2 2 4.4 O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl 10.1038/s41467-023-40064-9
2540 11173 111 None -1380 28 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 11173 111 None -1380 28 Human 5.0 pAC50 = 5.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
1481 8847 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
3749 8847 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
589 8847 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
6908 8847 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
CHEMBL1513 8847 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
DB01029 8847 116 None -109647 6 Human 4.0 pAC50 = 4.0 Functional
Compound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity methodCompound was evaluated for inhibition of human AGTR2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1038/s41467-023-40064-9
44377942 64228 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
CHEMBL165572 64228 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 530 6 2 5 5.9 O=S(=O)(Nc1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1)C(F)(F)F 10.1021/jm1013693
44355628 31678 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
CHEMBL134567 31678 0 None -5 2 Rat 6.0 pIC50 = 6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
10411653 31196 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
CHEMBL134151 31196 0 None -208 2 Rat 5.0 pIC50 = 5 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 5 1 5 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O 10.1021/jm00078a013
10410730 31390 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
CHEMBL134307 31390 0 None -6 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
10048220 32961 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL135704 32961 0 None -109 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10322995 122041 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
CHEMBL334832 122041 0 None -134 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 482 9 1 5 6.1 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C 10.1021/jm00078a014
10003482 172522 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL424643 172522 0 None -158 2 Rat 5.0 pIC50 = 5.0 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10364891 33017 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
CHEMBL135792 33017 0 None -33 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 421 5 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 10.1021/jm00078a013
192345 33008 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL135775 33008 6 None -12022 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10393397 29571 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL132807 29571 0 None -6 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 578 8 1 5 7.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10367704 29115 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL132408 29115 0 None -25 2 Rat 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10094520 31530 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
CHEMBL134433 31530 0 None -11 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
15698118 212922 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL86067 212922 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 537 10 2 6 5.2 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm1013693
44355660 28329 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL131676 28329 0 None -89 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
11743704 122276 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
CHEMBL335179 122276 0 None -3 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 10.1021/jm00078a013
10026268 123708 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
CHEMBL338505 123708 0 None -173 2 Rat 4.9 pIC50 = 4.9 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 440 6 1 5 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 10.1021/jm00078a013
10322504 33155 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135929 33155 0 None -19 2 Rat 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095493 32820 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
CHEMBL135521 32820 0 None -93 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
11754335 32075 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
CHEMBL134901 32075 0 None -186 2 Rat 4.8 pIC50 = 4.8 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 467 5 2 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 10.1021/jm00078a013
1610 9126 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3941 9126 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
3961 9126 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
590 9126 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
CHEMBL191 9126 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
DB00678 9126 95 None -954 11 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm1013693
44355662 33235 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL135999 33235 0 None -125 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
10411101 172444 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
CHEMBL424465 172444 0 None -676 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 7 2 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 10.1021/jm00078a014
19742811 64195 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL165354 64195 0 None 1 3 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
130762 105023 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
CHEMBL274447 105023 9 None 1 6 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm1013693
192567 123430 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL337007 123430 6 None -223 2 Rat 6.7 pIC50 = 6.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
10366811 31598 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
CHEMBL134491 31598 0 None -31 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 10.1021/jm00078a014
11744592 122281 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
CHEMBL335228 122281 0 None -33 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 6 0 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 10.1021/jm00078a013
10409549 122756 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL335514 122756 0 None -104 2 Rat 4.7 pIC50 = 4.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 414 7 2 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10027636 31366 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL134286 31366 0 None -70 2 Rat 5.7 pIC50 = 5.7 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
71455883 90539 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
CHEMBL2205685 90539 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1021/jm1013693
10048602 32822 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
CHEMBL135522 32822 0 None -37 2 Rat 4.6 pIC50 = 4.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 435 4 0 5 4.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N 10.1021/jm00078a013
9914666 123448 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL337086 123448 0 None -3388 2 Rat 5.6 pIC50 = 5.6 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
9846535 64289 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
CHEMBL166143 64289 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at angiotensin 2 receptorAntagonist activity at angiotensin 2 receptor
ChEMBL 427 5 2 4 5.4 O=C(O)c1ccccc1-c1ccc(CNc2nc(C(F)(F)F)nc3c2CCCC3)cc1 10.1021/jm1013693
10326140 123429 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL337006 123429 0 None -2884 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10365283 32625 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135345 32625 0 None -416 2 Rat 5.5 pIC50 = 5.5 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 428 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10393717 122877 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL335722 122877 0 None -524 2 Rat 6.4 pIC50 = 6.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
10344571 123392 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336773 123392 0 None -125 2 Rat 5.4 pIC50 = 5.4 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 468 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10027714 122215 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL335066 122215 0 None -398 2 Rat 5.3 pIC50 = 5.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10004112 32302 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL135089 32302 0 None -93 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10344052 123385 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336738 123385 0 None -107 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 9 1 5 5.7 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10437543 33039 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
CHEMBL135819 33039 0 None -7 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 550 7 2 5 6.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1021/jm00078a014
10414429 122775 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
CHEMBL335535 122775 0 None -363 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 522 5 1 5 5.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O 10.1021/jm00078a013
10434876 123396 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL336808 123396 0 None -7 2 Rat 6.2 pIC50 = 6.2 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 470 10 1 5 6.1 CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
10026868 30631 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL133653 30631 0 None -331 2 Rat 5.2 pIC50 = 5.2 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 452 5 1 6 5.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 10.1021/jm00078a013
10456041 32627 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL135346 32627 0 None -186 2 Rat 6.1 pIC50 = 6.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 442 8 1 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 10.1021/jm00078a014
10095589 122297 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL335289 122297 0 None -851 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
10345459 123548 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
CHEMBL337663 123548 0 None -43 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.
ChEMBL 490 9 1 5 5.8 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F 10.1021/jm00078a014
10250898 125266 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
CHEMBL341407 125266 0 None -37 2 Rat 5.1 pIC50 = 5.1 Functional
In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.
ChEMBL 408 4 0 5 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 10.1021/jm00078a013
10071193 211103 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
CHEMBL71485 211103 0 None - 0 Rat 8.7 pKd = 8.7 Functional
Antagonism against A-2 induced contraction of aortic rings of rabbit.Antagonism against A-2 induced contraction of aortic rings of rabbit.
ChEMBL 427 7 1 4 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc([C@H](c2ccccc2)[C@H](C)C(=O)O)cc1 10.1021/jm9508853
6918 7815 35 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
9804984 7815 35 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL189568 7815 35 None -7 2 Human 8.7 pKi = 8.7 Functional
Agonist activity at AT2 receptor in HEK293 cellsAgonist activity at AT2 receptor in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116790
6918 7815 35 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 7815 35 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 7815 35 None -7 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
6918 7815 35 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
9804984 7815 35 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
CHEMBL189568 7815 35 None 7 2 Rat 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 22802221
1610 9126 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 9126 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 9126 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 9126 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 9126 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 9126 95 None -2884 11 Rat 8.3 pIC50 = 8.3 Functional
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
36736 10247 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
598 10247 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
6324663 10247 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
CHEMBL356431 10247 0 None 2 2 Rat 8.1 pIC50 = 8.1 Functional
NoneNone
Drug Central None None None None None
123805 7205 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
46878481 7205 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
5578 7205 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
582 7205 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL3545347 7205 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
DB11720 7205 0 None -35 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
8374 9696 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 9696 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 9696 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 9696 42 None -38 3 Rat 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
8374 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
8374 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
9937291 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
9937291 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
9937291 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
CHEMBL34124 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
CHEMBL34124 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
CHEMBL34124 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
DB16266 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 23489258
DB16266 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507377
DB16266 9696 42 None 38 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 24507378
114899 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
114899 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
114899 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
596 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
596 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
596 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
CHEMBL1188080 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2314387
CHEMBL1188080 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 2590220
CHEMBL1188080 9794 15 None 64 2 Rat 9.0 pIC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 8469774
36736 10247 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
598 10247 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
6324663 10247 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
CHEMBL356431 10247 0 None 2 2 Rat 9.0 pIC50 = 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2590220
123794 7680 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
3944 7680 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
594 7680 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
CHEMBL1885579 7680 46 None - 1 Human 9.6 pIC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21542804
6894 7206 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938
91691124 7206 0 None 2 3 Human 9.9 pIC50 = 9.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17138938




Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Affinity)
# tested GPCRs
(Affinity)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
44348523 119956 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 119956 0 None - 0 Rat 10.3 pIC50 = 10.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
11930 7806 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
15780052 7806 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
CHEMBL289472 7806 0 None - 2 Rat 10.2 pIC50 = 10.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 10.1016/S0960-894X(01)80517-5
10033116 215015 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 215015 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
11765177 123786 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 123786 0 None - 0 Rat 10.2 pIC50 = 10.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
16133225 7207 52 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
172198 7207 52 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
2504 7207 52 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
45266664 7207 52 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
5272 7207 52 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL408403 7207 52 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
DB11842 7207 52 None 1 5 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting methodDisplacement of [125I]CGP 42112A from human recombinant AT2 receptor expressed in HEK293 cells measured after 4 hrs by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL385433 219129 2 None - 0 Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in HEK293 cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmc.2016.03.006
10259841 22930 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 22930 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10417195 115856 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 115856 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
10078554 123746 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 123746 0 None - 0 Rat 10.0 pIC50 = 10 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440174 174593 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL430659 174593 0 None - 0 Rat 10.0 pIC50 = 10 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 767 17 1 9 8.0 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL385189 219122 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cccs1)C(=O)O 10.1021/jm00108a043
10078800 115968 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 115968 0 None - 0 Rat 10.0 pIC50 = 10.0 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissuesInhibitory concentration against AT1 receptor from rat adrenal tissues
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9853391 123617 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 123617 1 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9853391 123617 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL338027 123617 1 None - 0 Human 9.9 pIC50 = 9.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm9504722
CHEMBL2391146 217191 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human angiotensin AT2 receptor by radioligand displacement assayBinding affinity to human angiotensin AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
10101351 175443 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 175443 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259525 22391 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 22391 0 None - 0 Rat 9.9 pIC50 = 9.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372810 112979 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 112979 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
10078800 115968 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 115968 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 123860 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 123860 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10033136 22845 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 22845 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
19430477 214910 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
CHEMBL98047 214910 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 8.1 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1ccccc1 10.1021/jm00015a016
10259468 125259 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 125259 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101606 22543 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 22543 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 123695 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 123695 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10440179 114176 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317962 114176 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 123694 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 123694 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 125259 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 125259 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259265 116820 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 116820 0 None - 0 Rat 9.8 pIC50 = 9.8 Binding
Inhibitory concentration against AT1 receptor from rat adrenal tissues.Inhibitory concentration against AT1 receptor from rat adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10372659 124868 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 124868 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10327728 104898 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 104898 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10078554 123746 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 123746 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10033116 215015 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98665 215015 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 766 17 1 8 8.6 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44348523 119956 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 119956 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
10032877 22321 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 22321 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
183134 211623 17 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL7550 211623 17 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10259525 22391 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 22391 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010071 124127 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 124127 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 211524 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 211524 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL2392353 217193 6 None - 1 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10033136 22845 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 22845 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10439837 23125 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 23125 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10032820 124082 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 124082 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
9853391 123617 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 123617 1 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101690 123639 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 123639 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10440144 123672 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 123672 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439715 123813 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 123813 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 109631 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 109631 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315344 111858 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 111858 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315078 211535 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 211535 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
15780085 124928 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL34082 124928 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10440144 123672 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 123672 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10032988 123695 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 123695 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101351 175443 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 175443 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315078 211535 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 211535 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10033126 174916 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL433005 174916 0 None - 0 Rat 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10078780 123694 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 123694 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10372451 124072 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 124072 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462683 120059 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 120059 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283480 107244 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290768 107244 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 9 1 8 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10259265 116820 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 116820 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10259265 116820 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL323506 116820 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462933 23654 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 23654 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
19754068 109510 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL304946 109510 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10101606 22543 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 22543 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10101608 123807 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 123807 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
44315282 103399 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 103399 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
44315351 111662 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 111662 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
9896750 10952 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
CHEMBL100119 10952 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm00015a016
10372550 171295 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 171295 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 123813 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 123813 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 123827 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 123827 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
11765177 123786 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 123786 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032851 23607 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 23607 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314761 109631 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 109631 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
9896750 10952 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
CHEMBL100119 10952 0 None - 0 Rat 9.6 pIC50 = 9.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 733 18 1 9 7.5 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)c1cccnc1 10.1021/jm9504722
10032877 22321 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 22321 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10009984 119957 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 119957 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
10078475 120107 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 120107 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987414 123827 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 123827 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 124175 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 124175 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 22309 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 22309 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 109726 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 109726 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895877 60663 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
CHEMBL160494 60663 1 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 653 12 2 8 7.1 CCCc1nc2c(C)c(NC(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm9504722
10439858 23633 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 23633 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 23700 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 23700 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
10010071 124127 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 124127 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292111 211524 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 211524 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19754061 109511 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL304947 109511 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
10462573 123787 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 123787 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10395335 123860 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 123860 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315349 67164 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 67164 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10394859 24201 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 24201 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
2583 10548 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
592 10548 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
65999 10548 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
CHEMBL1017 10548 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
DB00966 10548 118 None - 1 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 10.1016/j.ejmech.2012.01.009
10373120 124379 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 124379 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
10394859 24201 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 24201 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 111662 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 111662 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
15780090 107231 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL290669 107231 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 631 9 1 7 7.3 CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10101608 123807 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 123807 0 None - 0 Rat 9.5 pIC50 = 9.5 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259841 22930 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 22930 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372659 124868 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 124868 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314822 109726 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 109726 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10373120 124379 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 124379 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
44315144 103367 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 103367 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032851 23607 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 23607 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395076 175355 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 175355 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9874508 211459 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 211459 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9874508 211459 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
CHEMBL73876 211459 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1021/jm9504722
44338708 117221 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL324629 117221 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.0 CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
22850667 207579 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL60071 207579 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 542 11 1 3 6.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10032820 124082 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 124082 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10462683 120059 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 120059 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44314823 168665 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 168665 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 222686 28 None -1 2 Human 9.4 pIC50 = 9.4 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
9809637 210631 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68618 210631 0 None - 0 Rat 9.4 pIC50 = 9.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
9830680 107419 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 107419 0 None - 1 Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
15780094 106586 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285433 106586 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 651 9 1 7 7.4 CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL384352 219103 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
9917295 109735 17 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306407 109735 17 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 10.1016/S0960-894X(01)81115-X
10417321 22390 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 22390 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439819 176668 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 176668 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
15292113 102808 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 102808 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078800 115968 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 115968 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10485034 113963 1 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL316503 113963 1 None - 0 Rat 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 719 17 1 9 7.1 CCCc1nc(CC)c(C(=O)CCN(C(=O)CC)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
15292113 102808 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 102808 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10462598 120913 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 120913 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10259447 23700 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 23700 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL938 222686 28 None -1 2 Human 9.3 pIC50 = 9.3 Binding
Inhibition of human angiotensin II AT2 receptorInhibition of human angiotensin II AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmc.2010.07.034
10462933 23654 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 23654 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 120913 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 120913 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10009984 119957 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 119957 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
15292112 109725 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 109725 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 109855 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 109855 0 None - 0 Rat 9.3 pIC50 = 9.3 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10101690 123639 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 123639 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
9937291 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
CHEMBL34124 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
DB16266 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)80517-5
10327309 120668 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 120668 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10372451 124072 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 124072 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
8374 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
9937291 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
CHEMBL34124 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
DB16266 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81122-7
44338834 14630 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL108981 14630 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44338834 14630 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL108981 14630 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 627 11 1 8 7.0 CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44303887 210100 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64861 210100 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
8374 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
9937291 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL34124 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
DB16266 9696 42 None - 1 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1021/jm9504722
44315344 111858 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 111858 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
16133225 7207 52 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
172198 7207 52 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
2504 7207 52 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
45266664 7207 52 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
5272 7207 52 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
CHEMBL408403 7207 52 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
DB11842 7207 52 None 1 5 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL None None None None 10.1016/j.bmcl.2021.128086
11765454 124846 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 124846 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10349897 121205 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 121205 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315058 77228 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 77228 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315059 211491 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 211491 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10101606 22543 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122273 22543 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL385283 219126 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19430475 211031 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71125 211031 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F 10.1016/S0960-894X(00)80077-3
9940350 211537 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL74573 211537 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
9851889 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL302102 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
9940350 211537 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74573 211537 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10031067 107128 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL289614 107128 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
10031067 107128 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL289614 107128 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
10031067 107128 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289614 107128 4 None -2 3 Human 9.2 pIC50 = 9.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
44283174 106850 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL287250 106850 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 617 9 1 7 7.2 CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851889 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
CHEMBL302102 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)80595-3
9851889 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
CHEMBL302102 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81115-X
9851889 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
CHEMBL302102 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00019a004
10395076 175355 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 175355 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315058 77228 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 77228 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851889 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303886 107657 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293660 107657 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9851889 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL302102 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
9851889 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
CHEMBL302102 108851 0 None - 0 Rat 9.2 pIC50 = 9.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm9504722
9851889 108851 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
CHEMBL302102 108851 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm058225d
44315057 211608 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 211608 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10078475 120107 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 120107 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44283175 127148 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35324 127148 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 637 8 1 7 7.1 Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44315304 211789 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 211789 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44314823 168665 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 168665 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
9874508 211459 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 211459 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10439819 176668 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 176668 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44338697 116436 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
CHEMBL322471 116436 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 613 11 1 8 6.8 CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1021/jm00073a024
10372550 171295 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 171295 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
15292112 109725 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 109725 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44314780 109855 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 109855 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10462573 123787 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 123787 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL414533 219915 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
10259265 116820 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 116820 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against cloned human AT1 receptorInhibitory concentration against cloned human AT1 receptor
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
10327309 120668 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 120668 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
10439837 23125 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 23125 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
9892451 55514 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 55514 23 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10010164 124175 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 124175 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10032988 123695 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 123695 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765454 124846 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 124846 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10100951 121822 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 121822 0 None - 0 Rat 9.1 pIC50 = 9.1 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
20647138 107248 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL290829 107248 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
9918412 211041 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71172 211041 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
19430479 211048 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71220 211048 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
10462053 174836 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL432378 174836 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 664 15 4 8 5.9 CCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10327728 104898 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 104898 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315282 103399 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 103399 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
9917399 108923 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL302519 108923 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
9917399 108923 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
CHEMBL302519 108923 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C 10.1021/jm9504722
44315349 67164 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 67164 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44311675 108931 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302579 108931 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311676 109838 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307318 109838 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311412 112106 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311625 112106 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311072 210965 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70789 210965 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311736 210986 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70867 210986 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311452 211284 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL72595 211284 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
15780095 105371 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL276853 105371 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 595 9 1 7 6.5 CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
15780091 127774 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL35638 127774 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 618 9 1 8 6.1 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
9851082 107797 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL294512 107797 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(01)80554-0
9810305 105348 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL276674 105348 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9810305 105348 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL276674 105348 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
1037 8359 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
3940 8359 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
5281037 8359 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
588 8359 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
CHEMBL813 8359 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
DB00876 8359 69 None - 1 Rat 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 10.1021/jm00108a043
9810305 105348 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 105348 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315144 103367 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 103367 0 None - 0 Rat 9.0 pIC50 = 9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
9851082 107797 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
CHEMBL294512 107797 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm9504722
10395395 114071 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL317159 114071 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 768 17 1 10 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2ccncc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10033013 118430 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
CHEMBL328602 118430 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 750 17 1 10 7.3 CCCc1nc(CC)c(C(=O)CCN(C(=O)c2cccnc2)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1021/jm00015a016
9937227 208951 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 208951 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
10078661 215026 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL98746 215026 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 733 17 1 9 7.4 CCCc1nc(CC)c(C(=O)CCN(C(=O)C(C)C)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10259277 215093 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
CHEMBL99112 215093 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 715 18 1 9 7.4 CCCC(=O)N(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1)c1cccnc1 10.1021/jm00015a016
44315304 211789 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 211789 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315057 211608 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 211608 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL5272027 201389 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of angiotensin 2 (unknown origin)Inhibition of angiotensin 2 (unknown origin)
ChEMBL 846 21 4 9 8.0 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O 10.1016/j.ejmech.2019.111852
CHEMBL5315276 201389 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of angiotensin 2 (unknown origin)Inhibition of angiotensin 2 (unknown origin)
ChEMBL 846 21 4 9 8.0 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)[C@H](C(=O)O)C(C)C.CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O 10.1016/j.ejmech.2019.111852
44322202 113648 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314506 113648 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 692 17 4 8 6.7 CCCCCCC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44322203 113711 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL314827 113711 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 650 13 4 8 5.4 CCCc1nc(SC)c(C(O)(C(=O)O)C(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44321791 213392 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89053 213392 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 698 14 4 8 6.0 CCCc1nc(SC)c(C(O)(Cc2ccccc2)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10078554 123746 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338687 123746 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 12 2 9 6.2 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
11765560 22309 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 22309 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10417321 22390 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 22390 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
9810305 105348 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 105348 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
10485116 123631 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 123631 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
18965174 107645 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL293625 107645 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 507 12 1 3 5.2 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9870559 53642 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL154057 53642 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 8 1 4 5.6 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)C1CCCC1)C2 10.1016/S0960-894X(01)81122-7
19939495 214604 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 214604 0 None - 0 Rat 9.0 pIC50 = 9.0 Binding
Inhibitory concentration against AT2 receptor from rat adrenal tissues.Inhibitory concentration against AT2 receptor from rat adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10010071 124127 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 124127 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL216061 216095 15 None - 2 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00108a043
10395335 123860 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 123860 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10349897 121205 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 121205 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439858 23633 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 23633 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315060 109834 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 109834 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL938 222686 28 None -1 2 Human 8.9 pIC50 = 8.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm00065a013
15780089 106585 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL285432 106585 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 603 8 1 7 6.4 Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
10349732 125531 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL341828 125531 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 10.1021/jm00052a006
10101351 175443 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL436396 175443 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259489 23690 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 23690 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
22850669 209765 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63109 209765 0 None - 0 Rat 8.9 pIC50 = 8.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10321941 144925 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
CHEMBL37679 144925 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 458 10 2 5 5.4 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1Cl 10.1021/jm00108a043
20647138 107248 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290829 107248 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
10033136 22845 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122380 22845 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 10.1021/jm00019a004
10394859 24201 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL125760 24201 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 687 11 2 10 5.3 CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
20647138 107248 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL290829 107248 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 520 5 1 3 6.0 O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
19430442 210954 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL70726 210954 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
10078663 214566 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL96075 214566 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10100951 121822 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL334300 121822 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10078663 214566 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL96075 214566 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44381553 127114 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352947 127114 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10100951 121822 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 121822 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44315350 111995 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 111995 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10417321 22390 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122157 22390 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44348523 119956 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL331450 119956 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 10.1021/jm00019a004
9870914 210106 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64881 210106 0 None - 0 Rat 8.8 pIC50 = 8.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C(C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44299731 7208 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
585 7208 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL56448 7208 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
10395076 175355 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL435811 175355 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44315059 211491 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 211491 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19430462 109761 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306638 109761 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(00)80077-3
44321824 212343 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL81236 212343 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 642 13 4 8 5.5 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
22402434 55801 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
CHEMBL156100 55801 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 1 5 5.8 COc1ccc(COc2c(OC)ccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81122-7
44311617 109316 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL304065 109316 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 10.1016/S0960-894X(00)80077-3
44311538 109740 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL306435 109740 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311755 109911 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307866 109911 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 735 18 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311071 110192 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL308482 110192 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 8.0 CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 10.1016/S0960-894X(00)80077-3
44311752 111642 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL311018 111642 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 10.1016/S0960-894X(00)80077-3
10005139 64378 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
CHEMBL1668008 64378 0 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC(C(=O)O)=C2 10.1016/j.bmc.2010.10.043
14403498 107808 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL294558 107808 3 None - 0 Rat 8.0 pIC50 = 8 Binding
Binding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomesBinding affinity towards angiotensin II AT2 receptor subtype was determined using rat isolated adrenal cortical microsomes
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
44303640 206892 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59611 206892 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 511 12 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)cc1 10.1016/S0960-894X(01)80554-0
44303208 209325 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL61168 209325 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 555 12 1 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(C)c1 10.1016/S0960-894X(01)80554-0
44210590 65488 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168490 65488 0 None - 0 Rat 8.0 pIC50 = 8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078475 120107 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331632 120107 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 9 2 9 6.6 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
18965184 209695 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL62806 209695 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 504 4 0 2 7.3 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)C(C)CN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44330905 11182 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
CHEMBL101455 11182 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 746 19 1 8 8.2 CCCCN(CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F)C(=O)c1ccccc1 10.1021/jm00015a016
9937227 208951 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
CHEMBL60942 208951 0 None - 0 Rat 8.0 pIC50 = 8 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm00015a016
11755896 123750 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL338709 123750 0 None - 0 Rat 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 505 7 1 3 5.8 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
11765541 125786 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342605 125786 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9988057 112938 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
CHEMBL313691 112938 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 831 10 5 15 3.3 CC(=O)O[C@@H]1C2=C(C)[C@@H](OC(=O)[C@H](O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)[C@H]1O)C2(C)C 10.1016/0960-894X(95)00477-B
44311496 211023 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL71069 211023 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 722 15 2 8 7.2 CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1016/S0960-894X(00)80076-1
44379292 127112 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352934 127112 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 613 12 1 6 7.4 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81125-2
10077497 18141 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL1179757 18141 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
CHEMBL98426 18141 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 10.1021/jm00043a020
44328276 119504 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL330464 119504 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10077929 214124 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
CHEMBL93606 214124 0 None - 0 Rat 7.0 pIC50 = 7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 643 14 2 8 5.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1021/jm00043a020
15818748 106689 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL286134 106689 0 None - 0 Human 7.0 pIC50 = 7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 543 9 1 5 5.7 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311571 211234 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL72249 211234 0 None - 0 Human 6.0 pIC50 = 6 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303248 209532 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
CHEMBL61976 209532 0 None - 0 Rat 6.0 pIC50 = 6 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 414 8 1 6 4.4 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1C 10.1016/S0960-894X(01)80554-0
44311567 109790 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306922 109790 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 11 2 8 6.4 CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311450 110878 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309365 110878 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 652 12 2 8 6.4 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311497 174636 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL430997 174636 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 547 10 1 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311664 210942 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70638 210942 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 680 12 2 8 5.9 CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377125 62413 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162148 62413 0 None - 0 Rat 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
1610 9126 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3941 9126 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
3961 9126 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
590 9126 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
CHEMBL191 9126 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
DB00678 9126 95 None - 4 Human 5.0 pIC50 = 5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1016/S0960-894X(00)80076-1
44376747 126867 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350851 126867 0 None - 0 Rat 5.0 pIC50 = 5 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 510 11 2 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
9852384 107192 5 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL290214 107192 5 None - 0 Human 7.0 pIC50 = 7 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
9852384 107192 5 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
CHEMBL290214 107192 5 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm049715t
9852384 107192 5 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL290214 107192 5 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 640 12 1 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
23583071 194997 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL499234 194997 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1450 7 8 31 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)N4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
164613196 192218 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4861538 192218 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 951 23 12 10 1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
10440203 125765 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342492 125765 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315058 77228 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL194608 77228 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 637 10 3 8 5.6 Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315344 111858 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL311386 111858 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 12 2 8 5.2 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10258694 119364 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
CHEMBL330165 119364 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 10.1021/jm00043a020
10233073 214412 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
CHEMBL95198 214412 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 10.1021/jm00043a020
10438523 214923 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL98126 214923 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 10 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
57380412 77303 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947129 77303 0 None - 1 Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
15296724 126796 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
CHEMBL350220 126796 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 462 7 2 5 4.3 COc1ccc(NC(=O)N2Cc3ccc(OC)c(OCc4ccccc4)c3CC2C(=O)O)cc1 10.1016/S0960-894X(01)81122-7
11757357 214771 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97273 214771 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 552 9 1 6 5.8 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
23584461 185452 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL467872 185452 1 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1368 7 9 30 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)O)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
90663955 113553 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
CHEMBL3144487 113553 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL 1280 38 16 17 0.0 CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)C(N)[C@H](CC(C)C)C(C)=O 10.1021/jm00065a013
164625885 193045 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873899 193045 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303458 174661 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431137 174661 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(Cl)c1 10.1016/S0960-894X(01)80554-0
10417251 103680 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL265797 103680 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939453 119168 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL329679 119168 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10417251 103680 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL265797 103680 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL413925 219881 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
44381724 127086 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352771 127086 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10259265 116820 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL323506 116820 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 713 12 2 9 7.0 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44315180 109673 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 109673 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44373238 103862 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
CHEMBL267354 103862 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 1051 29 11 12 1.9 CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O 10.1021/jm9504722
44304147 107553 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
CHEMBL292939 107553 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 522 11 0 4 5.9 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 10.1016/S0960-894X(01)81007-6
44315057 211608 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL75401 211608 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 651 10 2 8 5.9 Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44322236 119605 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330744 119605 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 14 4 8 5.4 CCCCc1nc(SC)c(C(O)CC(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44323447 113678 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314605 113678 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 627 11 1 9 6.5 CCCCc1nc2ccn(C(C(=O)OC3CCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379269 63942 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164769 63942 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 644 12 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10438745 113993 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
CHEMBL316655 113993 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 10.1021/jm00043a020
10349597 118395 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
CHEMBL328434 118395 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 10.1021/jm00043a020
10416475 214483 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
CHEMBL95579 214483 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 10.1021/jm00043a020
44300735 107537 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL292829 107537 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 629 9 1 9 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
46910582 77128 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945009 77128 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
19385652 54292 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15458 54292 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 459 9 1 6 5.3 CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
19385680 105657 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
CHEMBL279103 105657 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 487 10 1 6 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC 10.1016/0960-894X(95)00185-V
15696755 154802 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL39345 154802 1 None - 0 Rat 4.9 pIC50 = 4.9 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 306 7 1 3 3.6 CCCCc1ncc(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44323530 213959 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92479 213959 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 586 10 1 8 5.1 CCCCc1nc2ccn(C(C(=O)N(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10259395 33768 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL136465 33768 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381552 127065 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352629 127065 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 10.1016/S0960-894X(01)81126-4
10349659 118320 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
CHEMBL327988 118320 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 10.1021/jm00043a020
10439275 174839 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
CHEMBL432392 174839 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 10.1021/jm00043a020
10054753 214925 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL98140 214925 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 629 9 2 7 5.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 10.1021/jm00043a020
44300615 203562 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL56549 203562 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 572 9 1 7 6.5 CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
44373417 59157 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
CHEMBL159004 59157 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 476 5 1 8 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 10.1021/jm9504722
57380649 77150 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945149 77150 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 549 10 2 4 6.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
11765394 125555 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
CHEMBL341986 125555 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 14 2 8 7.3 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C 10.1021/jm00052a006
19939409 113937 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316299 113937 0 None - 0 Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 710 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
136026557 213641 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL90663 213641 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 617 11 1 10 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 10.1016/0960-894X(95)00477-B
44309903 211173 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71925 211173 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
19939495 214604 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 214604 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
44309903 211173 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL71925 211173 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
44270330 58520 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15847 58520 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 10 1 5 6.2 CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
57380647 77129 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945010 77129 0 None - 1 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 591 12 2 6 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10349791 118356 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
CHEMBL328176 118356 0 None - 0 Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 10.1021/jm00043a020
10008962 126051 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343719 126051 0 None - 0 Rat 6.9 pIC50 = 6.9 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 615 10 2 8 5.4 CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
73347893 99401 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435828 99401 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10484866 38559 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL140619 38559 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 699 14 2 8 7.0 CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
44322097 113883 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315994 113883 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 608 12 4 8 4.6 CCCc1nc(SC)c(C(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381425 127232 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353980 127232 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
18965154 107376 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL291818 107376 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 490 4 0 2 6.9 CC1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
44303880 209752 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL63046 209752 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 12 1 3 6.1 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CCO)C1 10.1016/S0960-894X(01)81007-6
44304044 209965 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64280 209965 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 7 1 3 4.3 CCCCCN(C)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44323293 113810 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
CHEMBL315483 113810 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 629 14 1 9 6.8 CCCCCOC(=O)C(c1ccccc1)n1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1=O 10.1016/0960-894X(95)00477-B
44323357 119164 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329655 119164 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 648 11 1 8 6.7 CCCCc1nc2ccn(C(C(=O)N(C)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323352 213329 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88663 213329 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 9 1 9 5.2 CCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10326775 119016 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
CHEMBL329089 119016 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 10.1021/jm00043a020
10483726 214355 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL94910 214355 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00043a020
10349506 214838 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
CHEMBL97615 214838 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 10.1021/jm00043a020
44300637 107702 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL293949 107702 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 600 11 1 7 7.2 CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
10100413 205369 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57853 205369 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 620 9 1 7 7.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
15296725 172064 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL423236 172064 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 535 9 0 5 5.9 CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
46910583 77127 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1945008 77127 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 561 11 2 5 6.7 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
44379348 171700 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL422374 171700 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 558 10 1 7 4.7 CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
10439172 214262 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
CHEMBL94355 214262 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 644 13 2 8 5.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 10.1021/jm00043a020
44377171 126989 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL352042 126989 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 485 6 1 8 5.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 10.1016/S0960-894X(01)80193-1
15287894 61721 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16148 61721 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(95)00185-V
44381739 65559 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168771 65559 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
44381739 65559 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL168771 65559 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 656 10 2 7 6.4 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10326797 214353 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
CHEMBL94905 214353 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 10.1021/jm00043a020
10326460 214886 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL97897 214886 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 614 9 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 10.1021/jm00043a020
44327912 214914 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
CHEMBL98068 214914 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC 10.1021/jm00043a020
44348153 124748 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
CHEMBL340367 124748 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 10.1021/jm00075a033
44210836 63283 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL163523 63283 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 453 6 1 8 3.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 10.1016/S0960-894X(01)80193-1
73357017 99404 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435831 99404 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 483 10 2 4 6.2 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
44323532 213913 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL92206 213913 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccc(Cl)cc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
9830680 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL292150 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
9830680 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL292150 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
10372497 125524 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341783 125524 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9830680 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL292150 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00043a020
10078800 115968 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321531 115968 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 751 13 2 8 7.6 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
9830680 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
CHEMBL292150 107419 0 None - 1 Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm9504722
19754050 210659 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68786 210659 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 603 15 2 7 6.6 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 10.1016/S0960-894X(01)81115-X
44381528 65767 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169009 65767 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 548 10 2 8 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10394995 118171 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
CHEMBL327191 118171 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 10.1021/jm00043a020
10077743 214736 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
CHEMBL97068 214736 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 10.1021/jm00043a020
44304148 210068 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL64714 210068 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 458 4 1 3 4.3 CN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)c1ccccc1 10.1016/S0960-894X(01)81007-6
22402428 55525 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155847 55525 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 450 6 2 4 4.5 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Nc1ccc(F)cc1)C2 10.1016/S0960-894X(01)81122-7
15229605 54928 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15517 54928 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 463 7 1 5 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 10.1016/0960-894X(95)00185-V
44323448 103625 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL265291 103625 0 None - 0 Rat 4.8 pIC50 = 4.8 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 559 10 2 8 5.1 CCCCc1nc2ccn(C(C(=O)O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
11764788 107635 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL293501 107635 0 None - 1 Rat 6.8 pIC50 = 6.8 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9810305 105348 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL276674 105348 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
9895212 126418 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL346728 126418 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm9504722
44385182 67848 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL176473 67848 0 None - 0 Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 637 10 3 7 5.7 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00116-3
10031920 114764 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
CHEMBL319404 114764 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 10.1021/jm00043a020
44372814 126568 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
CHEMBL348157 126568 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 672 11 2 6 6.7 CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 10.1021/jm9504722
44303888 210058 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64674 210058 0 None - 0 Rat 6.8 pIC50 = 6.8 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 552 12 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10390872 122924 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
CHEMBL335778 122924 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 10.1021/jm00050a002
44377086 126729 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349652 126729 0 None - 0 Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 546 11 2 7 4.8 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
10101582 126154 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
CHEMBL344466 126154 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 15 2 8 7.4 CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 10.1021/jm00052a006
5311348 107449 4 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
CHEMBL292277 107449 4 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1016/S0960-894X(01)81007-6
10484986 125475 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341715 125475 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 713 11 1 9 6.8 CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
1952 8990 4 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
5312129 8990 4 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
CHEMBL1182768 8990 4 None - 2 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F 10.1021/jm00043a020
9960852 113959 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL316482 113959 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10416957 118276 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
CHEMBL327791 118276 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 7 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 10.1021/jm00043a020
10010125 214810 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97464 214810 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 10.1021/jm00043a020
136059719 195908 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL510526 195908 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1438 10 9 31 4.5 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44300827 108544 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL299897 108544 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 602 8 1 7 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
44348355 120164 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
CHEMBL331797 120164 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 10.1021/jm00075a033
44311289 109002 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL302964 109002 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311455 109521 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305017 109521 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311754 109774 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306761 109774 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 757 16 1 9 9.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311715 109973 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL308323 109973 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311435 210801 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL69721 210801 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311434 210903 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70370 210903 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311414 211002 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70935 211002 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311413 211130 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL71639 211130 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311753 211390 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL73283 211390 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
3936 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
6603900 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL288174 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assayDisplacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT2R (unknown origin) by radioligand binding assay
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116804
44303191 174665 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL431162 174665 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 529 12 1 7 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(F)c1 10.1016/S0960-894X(01)80554-0
3936 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
3936 8991 35 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
6603900 8991 35 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL288174 8991 35 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrsDisplacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2010.03.064
44322095 113787 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315327 113787 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCc1nc(SC)c(C(O)(CC)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259841 22930 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL122401 22930 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10259447 23700 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
CHEMBL125280 23700 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1021/jm00019a004
11765177 123786 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338888 123786 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
3936 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
6603900 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
CHEMBL288174 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm9504722
44372744 58925 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
CHEMBL158795 58925 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 10.1021/jm9504722
3936 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 8991 35 None -2 4 Human 8.7 pIC50 = 8.7 Binding
Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesInhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
19430458 210853 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70100 210853 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 10.1016/S0960-894X(00)80077-3
10010234 105203 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL275552 105203 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10078320 213294 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL88446 213294 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 684 13 4 8 5.8 CCCc1nc(SC)c(C(O)(C(=O)O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381426 127050 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352502 127050 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10349897 121205 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL333224 121205 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10259489 23690 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
CHEMBL125231 23690 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl 10.1021/jm00019a004
10078780 123694 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338433 123694 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10259468 125259 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL341369 125259 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44309938 211079 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL71388 211079 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
19802473 205484 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL58156 205484 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 415 5 1 7 4.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
10439862 125550 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL341934 125550 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10010195 125962 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343142 125962 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10032851 23607 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL124771 23607 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10485116 123631 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
CHEMBL338101 123631 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00052a006
9895984 211528 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL74476 211528 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10485116 123631 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
CHEMBL338101 123631 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1021/jm00019a004
10372810 112979 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL313868 112979 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F 10.1016/S0960-894X(01)80595-3
44315180 109673 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 109673 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
9895984 211528 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 211528 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9892451 55514 23 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155836 55514 23 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9895984 211528 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
CHEMBL74476 211528 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1021/jm9504722
10101284 214181 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL93907 214181 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
10101284 214181 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL93907 214181 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
16133225 7207 52 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
172198 7207 52 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
2504 7207 52 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
45266664 7207 52 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
5272 7207 52 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
CHEMBL408403 7207 52 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
DB11842 7207 52 None 1 5 Human 8.6 pIC50 = 8.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None None 10.1021/jm00065a013
11765560 22309 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121872 22309 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10010071 124127 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339722 124127 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10101284 214181 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 214181 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
44315060 109834 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 109834 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
10032877 22321 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL121907 22321 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10462683 120059 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL331507 120059 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10417195 115856 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL321313 115856 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 685 13 2 9 6.2 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1016/S0960-894X(01)80595-3
44310069 210517 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67801 210517 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10009984 119957 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
CHEMBL331455 119957 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F 10.1021/jm00019a004
44303884 209612 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62422 209612 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 586 11 1 3 6.6 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44381403 65940 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169968 65940 0 None - 0 Rat 8.6 pIC50 = 8.6 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
10259657 126171 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344597 126171 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44381413 127500 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354779 127500 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
9987414 123827 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339113 123827 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
44311453 210816 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL69839 210816 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311557 211062 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL71286 211062 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311558 211501 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74236 211501 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303388 169686 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL417393 169686 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 539 12 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44303459 207066 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
CHEMBL59728 207066 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 586 13 1 10 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c([N+](=O)[O-])c1 10.1016/S0960-894X(01)80554-0
44303197 209015 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60992 209015 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 619 12 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Br)c1 10.1016/S0960-894X(01)80554-0
10394727 109839 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307321 109839 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 672 15 2 9 5.4 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
44210589 65370 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168413 65370 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
11765454 124846 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL340473 124846 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10092454 107023 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
CHEMBL288705 107023 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II induced contractions in rabbit aortic ringsInhibition of Angiotensin II induced contractions in rabbit aortic rings
ChEMBL 401 7 2 5 4.9 CCCCc1nc2ccnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00037a014
44303859 207770 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL60209 207770 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 514 8 1 3 5.8 CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 10.1016/S0960-894X(01)81007-6
9896877 67006 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL174080 67006 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 748 6 1 8 8.3 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
44311584 109557 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305239 109557 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 695 16 1 8 8.1 CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 10.1016/S0960-894X(00)80077-3
44311406 110584 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309081 110584 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10480819 28578 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL131940 28578 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 492 6 1 3 6.1 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44311635 109001 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
CHEMBL302959 109001 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 581 10 2 9 4.3 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(00)80076-1
44311499 211178 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL71953 211178 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 557 17 2 7 6.6 CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44384389 136615 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
CHEMBL367569 136615 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 10.1016/0960-894X(96)00116-3
10429298 25674 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL128416 25674 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44210864 154884 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39352 154884 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 503 8 1 5 4.8 CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
9850811 161519 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL39996 161519 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 561 8 1 6 5.3 CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311616 108917 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL302485 108917 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311776 109792 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306924 109792 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10255071 170243 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419974 170243 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 0 4 5.6 COC(=O)C1Cc2c(cccc2-c2ccc(OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9981762 170245 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL419979 170245 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 5 0 3 5.6 COC(=O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44379347 127265 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354338 127265 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 544 9 1 7 4.3 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44377075 126755 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349869 126755 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 479 10 1 6 4.1 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
15287882 56517 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15670 56517 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 414 9 1 4 5.6 CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
22407453 56532 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15671 56532 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9987311 123535 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337588 123535 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 706 12 1 9 6.7 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
14952914 161689 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
CHEMBL40089 161689 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 410 9 2 5 5.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(O)c(C)c1 10.1021/jm00108a043
44338666 117735 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL326217 117735 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 9 1 8 5.5 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
44379335 126999 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352137 126999 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 574 10 2 6 6.0 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1016/S0960-894X(01)81125-2
44379293 127068 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL352639 127068 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 611 10 1 6 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1016/S0960-894X(01)81125-2
44376780 63278 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL163486 63278 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 509 10 1 7 4.1 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44300734 108583 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL300154 108583 0 None - 0 Rat 7.7 pIC50 = 7.7 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 586 9 1 7 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10049400 162219 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
CHEMBL40381 162219 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Tested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assayTested in vitro for Angiotensin II receptor, type 2 binding affinity using rabbit aorta binding assay
ChEMBL 449 8 1 5 5.6 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 10.1016/0960-894X(94)00476-V
44323358 119282 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL329887 119282 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 626 10 1 8 6.0 CCCCc1nc2ccn(C(C(=O)N3CCCCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
19939398 114111 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
CHEMBL317547 114111 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 10.1021/jm00043a020
10055534 164240 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL407919 164240 0 None - 0 Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 10.1021/jm00043a020
44338833 15951 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL110265 15951 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 537 9 2 8 5.4 CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 100763 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24861 100763 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
15231091 100763 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL24861 100763 0 None - 0 Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 565 10 1 8 5.9 CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL443325 220700 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSSC[C@H](C(=O)N[C@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H]1C[C@H](CN1C(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)SS2 10.1021/jm00065a013
44303857 107587 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
CHEMBL293195 107587 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O 10.1016/S0960-894X(01)81007-6
10417144 39754 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL141592 39754 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44303852 109126 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL303755 109126 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 524 11 2 4 5.5 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
18950586 22336 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
CHEMBL122017 22336 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm00075a033
44377058 126784 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350121 126784 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
10482937 173916 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL321086 173916 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL429058 173916 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 560 10 1 7 5.3 CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
14956757 74367 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
CHEMBL19018 74367 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00052a006
14956757 74367 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
CHEMBL19018 74367 0 None - 1 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00043a020
4189 213701 96 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -38 34 Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
71455883 90539 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL2205685 90539 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 495 6 2 7 4.7 O=c1c(O)c(Oc2ccccc2-c2ccc(CNc3nc(C(F)(F)F)nc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44372686 103430 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
CHEMBL263714 103430 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 600 4 2 7 6.2 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O 10.1021/jm9504722
44211677 137392 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
CHEMBL368149 137392 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 614 4 2 7 6.6 CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O 10.1016/0960-894X(96)00116-3
164623569 192966 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4872735 192966 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1008 26 12 10 2.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44348302 23263 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
CHEMBL123562 23263 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm00075a033
11764826 105060 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
CHEMBL274710 105060 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 648 11 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 10.1021/jm00043a020
44348302 23263 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
CHEMBL123562 23263 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 527 12 1 5 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 10.1021/jm9504722
10028460 123299 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
CHEMBL336180 123299 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00050a002
10349512 214786 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97332 214786 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 10.1021/jm00043a020
19385665 57835 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
CHEMBL15788 57835 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 9 1 5 6.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C 10.1016/0960-894X(95)00185-V
10028815 214874 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL97783 214874 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 496 8 1 6 4.4 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 10.1021/jm00043a020
CHEMBL411657 219733 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CSS2)N(C(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C1 10.1021/jm00065a013
10078397 18881 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL1184032 18881 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL329290 18881 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00043a020
168298448 199482 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
CHEMBL5219534 199482 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)Inhibition of Angiotensin 2 binding to Angiotensin 2 receptor (unknown origin)
ChEMBL 477 5 2 4 5.8 O=c1c(O)c(-c2ccccc2-c2ccc(CNc3cc(C(F)(F)F)cc4c3CCCC4)cc2)c1=O 10.1016/j.ejmech.2020.112872
44211576 113895 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL316063 113895 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 573 10 1 9 5.2 CCCCc1nc2ccn(C(C(=O)OC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
136059721 195777 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508699 195777 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1537 12 10 33 3.3 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10429298 25674 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128416 25674 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 371 4 1 2 3.9 O=C(O)C1Cc2ccccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44300838 205449 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL57976 205449 0 None - 0 Rat 4.6 pIC50 = 4.6 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 530 7 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10009968 119324 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
CHEMBL329942 119324 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 10.1021/jm00043a020
10372341 174977 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
CHEMBL433375 174977 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 10.1021/jm00043a020
16725318 195742 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL508306 195742 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1494 11 9 32 4.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
192626 22431 14 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
CHEMBL122212 22431 14 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 499 11 1 5 6.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 10.1021/jm00075a033
9978845 137490 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL36846 137490 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 408 9 1 3 5.6 CCCCc1ncc(/C=C(\Cc2ccccc2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL417584 220014 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9939191 105722 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 105722 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 105722 1 None - 1 Rat 6.6 pIC50 = 6.6 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
10326972 119038 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
CHEMBL329099 119038 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 10.1021/jm00043a020
10077555 214189 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
CHEMBL93956 214189 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 10.1021/jm00043a020
19102815 214657 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 214657 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
19385603 105555 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278234 105555 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 455 9 1 5 5.6 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL408885 219515 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
19754062 109762 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL306641 109762 0 None - 0 Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 604 13 3 7 5.9 CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10349029 214875 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
CHEMBL97812 214875 0 None - 0 Rat 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 10.1021/jm00043a020
9888865 64271 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
CHEMBL165974 64271 0 None - 0 Rat 5.6 pIC50 = 5.6 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 429 6 1 6 4.4 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 10.1016/S0960-894X(01)80193-1
10055448 37536 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139582 37536 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 691 13 2 8 7.3 CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44379334 64885 1 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167584 64885 1 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 585 10 2 9 4.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81125-2
44381603 65890 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169798 65890 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 532 8 2 7 3.8 CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/S0960-894X(01)81126-4
133031 107636 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
CHEMBL293511 107636 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/0960-894X(96)00017-0
133031 107636 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
CHEMBL293511 107636 21 None - 1 Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00050a002
19385675 58148 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15816 58148 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 445 8 1 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
44311537 109109 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303647 109109 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311580 109556 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL305238 109556 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311182 109804 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL307008 109804 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311619 109847 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL307359 109847 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311185 110968 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL309790 110968 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311073 210979 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70843 210979 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311184 211200 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
CHEMBL72099 211200 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 10.1016/S0960-894X(00)80077-3
44311183 211479 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74069 211479 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311735 211531 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL74514 211531 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9937227 208951 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60942 208951 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1016/S0960-894X(01)80554-0
9851082 107797 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 107797 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
9987283 168721 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL415502 168721 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 705 16 1 9 6.7 CCCc1nc(CC)c(C(=O)CCN(C(C)=O)c2cccnc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
133031 107636 21 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL293511 107636 21 None - 1 Rat 8.5 pIC50 = 8.5 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
9937227 208951 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
CHEMBL60942 208951 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 543 12 1 7 5.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)c(F)c1 10.1021/jm9504722
10032820 124082 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339672 124082 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
10372659 124868 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL340632 124868 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44315351 111662 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL311160 111662 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 10.1016/0960-894X(94)85036-4
44381402 65939 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169967 65939 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15780064 106399 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL284123 106399 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 613 10 1 8 6.7 CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44381671 127205 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353800 127205 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
15292113 102808 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL259843 102808 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
10032858 36534 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
CHEMBL138690 36534 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 10.1021/jm00052a006
9853391 123617 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338027 123617 1 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10439715 123813 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339040 123813 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10350123 64377 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
CHEMBL1668007 64377 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 713 12 1 9 6.0 CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F 10.1016/j.bmc.2010.10.043
19939418 115047 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL319730 115047 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
19939495 214604 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL96314 214604 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 728 12 1 7 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1016/S0960-894X(01)80595-3
10395335 123860 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL339256 123860 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F 10.1021/jm00019a004
44315144 103367 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL263191 103367 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44381527 65848 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169568 65848 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
44210588 127123 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL353037 127123 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10440144 123672 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338342 123672 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10462573 123787 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338889 123787 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44382947 66007 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
CHEMBL170290 66007 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 813 19 4 12 6.4 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)CCNc1ccc([N+](=O)[O-])c2nonc12 10.1016/S0960-894X(00)80690-3
10101608 123807 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339004 123807 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 10.1021/jm00019a004
10372451 124072 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL339605 124072 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10010164 124175 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL339806 124175 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 729 11 2 9 6.0 CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
10101284 214181 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
CHEMBL93907 214181 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.In vitro inhibitory activity against angiotensin II type 2 receptor in rat adrenal membrane preparations.
ChEMBL 705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00019a004
9850834 161441 17 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL39959 161441 17 None - 1 Rat 8.4 pIC50 = 8.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10032988 123695 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL338434 123695 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44321825 113887 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL316021 113887 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 636 13 4 8 5.1 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44309700 109962 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308237 109962 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 651 13 2 7 7.2 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
10433752 25693 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128527 25693 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44283372 107196 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
CHEMBL290286 107196 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)80517-5
9875044 214808 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
CHEMBL97446 214808 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 10.1021/jm00043a020
44303835 108543 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
CHEMBL299887 108543 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 494 11 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](CO)C1 10.1016/S0960-894X(01)81007-6
44283372 107196 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
CHEMBL290286 107196 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 447 5 1 2 5.5 O=C(O)[C@@H]1Cc2cc(-c3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm9504722
44311609 109585 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL305369 109585 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 701 13 1 8 8.6 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311428 109746 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306473 109746 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 647 17 1 8 7.1 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44311583 210899 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL70353 210899 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 610 12 1 8 6.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
11740800 25609 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL128065 25609 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 385 4 1 2 4.2 Cc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10386376 25709 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
CHEMBL128594 25709 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 402 4 1 3 4.5 CN(C(=O)N1Cc2ccc(Oc3ccccc3)cc2CC1C(=O)O)c1ccccc1 10.1021/jm00077a001
9939191 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL279629 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
CHEMBL97539 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00052a006
44323387 112764 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL313142 112764 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 600 11 2 8 5.6 CCCCc1nc2ccn(C(C(=O)NC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323364 118677 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328780 118677 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 599 10 1 8 6.6 CCCCc1nc2ccn(C(C(=O)C(C)(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311758 211450 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL73780 211450 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 626 12 3 7 6.7 CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
9939191 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL279629 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
CHEMBL97539 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 2 to displace 125I[Sar,Ile] from rat brain tissue preparation
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81132-X
44379350 127563 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355443 127563 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 599 10 1 7 6.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1016/S0960-894X(01)81125-2
9939191 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL279629 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
CHEMBL97539 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00019a004
9939191 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL279629 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97539 105722 1 None - 1 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10348847 119366 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
CHEMBL330170 119366 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 615 10 2 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 10.1021/jm00043a020
10054912 214411 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
CHEMBL95197 214411 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 10.1021/jm00043a020
10054827 170917 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL42101 170917 0 None - 1 Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385729 57653 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15774 57653 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 471 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 10.1016/0960-894X(95)00185-V
15818746 130847 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
CHEMBL36324 130847 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2The compound was tested for the ability to displace 50% of totally specifically bound [125I]- Ang II from Angiotensin II receptor, type 2
ChEMBL 529 8 1 5 5.3 CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80526-6
44311775 109791 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306923 109791 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 582 11 1 7 7.3 CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303636 175877 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
CHEMBL439936 175877 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 418 8 1 6 4.2 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F 10.1016/S0960-894X(01)80554-0
44311681 109800 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306961 109800 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 592 11 2 9 4.8 CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44384870 66820 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173643 66820 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(96)00116-3
44270285 105841 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL280456 105841 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 7 1 5 4.7 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
9980304 105312 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
CHEMBL276381 105312 0 None - 0 Rat 4.5 pIC50 = 4.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 433 9 3 8 1.4 CCCCc1nc(C(N)=O)c(C(N)=O)n1Cc1ccc(-n2cccc2-c2nn[nH]n2)cc1 10.1021/jm00053a013
10258916 36484 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
CHEMBL138654 36484 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 11 1 10 6.1 CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00052a006
14952906 107281 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
CHEMBL291086 107281 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1[N+](=O)[O-] 10.1021/jm00108a043
11764788 107635 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 107635 0 None - 1 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against Angiotensin II receptor, type 2 bindingInhibitory activity against Angiotensin II receptor, type 2 binding
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
10439253 119098 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
CHEMBL329255 119098 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 10.1021/jm00043a020
164611280 191778 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4854474 191778 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 969 22 11 11 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10077328 213251 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88170 213251 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 601 11 1 9 6.0 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44315060 109834 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL307290 109834 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 10 2 9 4.9 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44404967 142196 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL372814 142196 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
44323345 113781 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315302 113781 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 557 10 1 8 5.6 CCCCc1nc2ccn(C(C(C)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10372723 114095 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL317368 114095 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 12 1 7 7.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1021/jm00043a020
15231094 146075 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL37919 146075 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 641 12 1 8 7.4 CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44309719 210633 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL68638 210633 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1016/S0960-894X(01)81115-X
44323365 118852 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328997 118852 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparationIn vitro binding affinity of compound was determined against Angiotensin II receptor, type 2 in rat adrenal medulla preparation
ChEMBL 619 11 1 8 6.9 CCCCc1nc2ccn(C(C(=O)c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379270 63631 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164395 63631 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 580 9 1 7 5.2 CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10010027 214811 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97465 214811 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 10.1021/jm00043a020
130762 105023 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL274447 105023 9 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm00053a013
44270306 58951 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15882 58951 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 5 6.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 10.1016/0960-894X(95)00185-V
5311345 9795 46 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
597 9795 46 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
CHEMBL321820 9795 46 None 10 2 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm049715t
10394712 126155 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344467 126155 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 671 12 2 8 6.2 CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
122189454 130034 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
CHEMBL3613974 130034 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 497 7 1 5 4.1 COc1ccc(CN2C=NC3CN(C(=O)C(c4ccccc4)c4ccccc4)C(C(=O)O)CC32)cc1C 10.1016/j.bmc.2015.07.045
5311345 9795 46 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
597 9795 46 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
CHEMBL321820 9795 46 None - 2 Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1021/jm9504722
44379217 64923 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167929 64923 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 608 10 2 6 7.1 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
15287883 104986 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL274260 104986 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 415 8 1 5 4.9 CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
10461785 18695 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL1182712 18695 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
CHEMBL262296 18695 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 639 10 1 9 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 10.1021/jm00043a020
10032342 214801 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
CHEMBL97394 214801 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 10.1021/jm00043a020
44303941 210034 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL64575 210034 0 None - 0 Rat 7.5 pIC50 = 7.5 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 580 13 1 5 6.0 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)OCC)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
22402431 55874 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156165 55874 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 575 8 1 4 6.8 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C2 10.1016/S0960-894X(01)81122-7
44384871 136098 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
CHEMBL367095 136098 0 None - 0 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 726 14 1 7 8.0 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 10.1016/0960-894X(96)00116-3
18950609 23177 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
CHEMBL123084 23177 0 None - 0 Rat 5.5 pIC50 = 5.5 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl 10.1021/jm00075a033
44321626 112743 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313005 112743 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 616 14 3 9 4.8 CCCCc1nc(SC)c(C(C)(O)C(=O)OCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809961 113938 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL316300 113938 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1016/S0960-894X(01)80595-3
9809961 113938 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL316300 113938 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9809961 113938 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
CHEMBL316300 113938 2 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00043a020
44323350 113796 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315400 113796 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3cccc(Cl)c3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
57380414 77305 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
CHEMBL1947131 77305 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
ChEMBL 547 10 2 5 6.6 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2012.01.009
10028545 27777 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
CHEMBL131156 27777 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm00050a002
10009273 114002 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
CHEMBL316706 114002 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 10.1021/jm00043a020
15236320 179385 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL449095 179385 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 548 10 1 7 6.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44315059 211491 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74144 211491 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 671 11 2 9 5.9 CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
2911265 107619 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
CHEMBL293414 107619 13 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 476 4 0 2 6.5 O=C(N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1)N(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81007-6
183134 211623 17 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL7550 211623 17 None - 1 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81145-8
9938088 109258 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 109258 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
15230315 61211 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL160930 61211 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 552 8 0 7 5.7 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc([N+](=O)[O-])cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
14403498 107808 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
CHEMBL294558 107808 3 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Compound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assayCompound was evaluated for inhibition of Angiotensin II receptor, type 2 in rat midbrain AT2 assay
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1016/S0960-894X(01)81007-6
44322234 213487 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89769 213487 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 8 5.1 CCCCc1nc(SC)c(C(=O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
9986299 165230 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
CHEMBL409058 165230 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 10.1021/jm00043a020
44322235 119426 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL330302 119426 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 620 13 3 7 6.0 CCCCc1nc(SC)c(C(C)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10032193 125923 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL342843 125923 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44211506 64315 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166338 64315 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 557 10 1 6 5.8 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311456 109075 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL303427 109075 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
71611145 191641 2 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4852514 191641 2 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1072 29 14 13 -0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
44303195 209993 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
CHEMBL64411 209993 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 559 12 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(F)c1 10.1016/S0960-894X(01)80554-0
44331176 215134 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL99438 215134 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 732 18 1 8 7.8 CCCc1nc(CC)c(C(=O)CCN(CCC)C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10010311 37300 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139325 37300 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10327728 104898 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL273542 104898 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 749 9 2 9 6.7 CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10439819 176668 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL444065 176668 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 161441 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
CHEMBL39959 161441 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/ml500427r
9850834 161441 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL39959 161441 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmcl.2015.10.084
9850834 161441 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL39959 161441 17 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranesBinding affinity towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial membranes
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
19102786 213968 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
CHEMBL92533 213968 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1016/S0960-894X(01)80595-3
44309702 210519 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67805 210519 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 591 13 2 8 6.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10439837 23125 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122917 23125 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F 10.1021/jm00019a004
10462598 120913 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
CHEMBL332909 120913 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F 10.1021/jm00019a004
10327537 123455 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL337118 123455 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10439848 125988 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL343309 125988 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9852499 127241 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354080 127241 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 10.1016/S0960-894X(01)81126-4
44314761 109631 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305647 109631 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F 10.1016/0960-894X(94)85036-4
44315350 111995 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 111995 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
In vivo inhibitory concentration against AT2 receptor of rat adrenal membraneIn vivo inhibitory concentration against AT2 receptor of rat adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44304123 207356 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL59913 207356 0 None - 0 Rat 8.4 pIC50 = 8.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 508 11 1 3 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
44210585 127185 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
CHEMBL353615 127185 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 10.1016/S0960-894X(01)81126-4
10327309 120668 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
CHEMBL332576 120668 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F 10.1021/jm00019a004
44322096 105177 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL275449 105177 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 622 12 4 8 4.8 CCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10259411 37431 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139452 37431 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL408886 219516 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CCSS2 10.1021/jm00065a013
22402420 55836 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156129 55836 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 521 9 1 4 5.5 COc1ccc2c(c1OCCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
19939454 214336 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
CHEMBL94793 214336 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 761 15 2 8 8.2 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 10.1016/S0960-894X(01)80595-3
10003751 25610 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL128066 25610 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 447 5 1 2 5.5 O=C(O)C1Cc2c(cccc2-c2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
5311348 107449 4 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
CHEMBL292277 107449 4 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm00077a001
10455982 123425 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
CHEMBL336991 123425 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 441 8 1 2 5.6 CCCCCc1cccc2c1CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/jm00077a001
10435148 124912 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340778 124912 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 477 6 1 3 5.5 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
44303430 107811 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL294578 107811 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 541 12 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)cc1 10.1016/S0960-894X(01)80554-0
44303878 105467 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
CHEMBL277567 105467 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 452 5 1 3 4.3 CC(C)N(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1)C(C)C 10.1016/S0960-894X(01)81007-6
22402433 56371 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL156587 56371 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 2 5 5.2 COc1ccc2c(c1Oc1ccc(N)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
9851082 107797 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL294512 107797 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang IIInhibitory concentration against Angiotensin II receptor type 2 with [125I]-[Sar1,Ile8]Ang II
ChEMBL 573 12 1 8 5.5 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
44311543 110918 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL309455 110918 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 643 14 1 8 6.3 CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10410436 124582 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL340187 124582 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 430 5 1 3 4.4 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)N(C)c2ccccc2)C3)cc1 10.1021/jm00077a001
18950592 23562 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
CHEMBL124541 23562 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 10.1021/jm00075a033
44309902 109894 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL307757 109894 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
44311663 210968 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70796 210968 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 561 10 2 7 5.8 CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311569 211483 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL74113 211483 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 625 13 2 7 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44381714 65895 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169827 65895 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 732 11 1 7 7.6 CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81126-4
10416501 119187 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL329759 119187 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 9 1 7 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
10349392 214829 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
CHEMBL97557 214829 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 10.1021/jm00043a020
44311607 210962 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70770 210962 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 517 9 3 8 4.5 CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44211673 66494 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL172376 66494 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 678 4 1 8 6.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
44300826 205517 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
CHEMBL58291 205517 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81145-8
10099830 115268 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
CHEMBL319955 115268 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 584 9 1 7 4.9 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1021/jm00043a020
44270278 105640 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL278983 105640 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 443 8 1 5 5.4 CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
73349424 99406 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435833 99406 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 495 7 1 4 6.3 CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44379268 126832 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL350554 126832 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
10417431 115885 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
CHEMBL321363 115885 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 10.1021/jm00043a020
44322967 174721 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
CHEMBL431592 174721 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 712 15 1 10 7.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccn(C(C(=O)OC(C)C)c4ccccc4)c(=O)c32)cc1 10.1016/0960-894X(95)00477-B
10032583 19121 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL1185398 19121 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
CHEMBL411487 19121 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 10.1021/jm00043a020
3082918 101844 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL25528 101844 1 None - 0 Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 340 7 1 3 4.2 CCCCc1nc(Cl)c(CC(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
60148656 99402 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435829 99402 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
44322233 118407 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL328480 118407 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 644 12 2 11 4.5 CCCCc1nc(SC)c(C(=O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
10047444 107123 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL289543 107123 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 414 9 1 4 5.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
10010047 214730 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
CHEMBL97020 214730 0 None - 0 Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 10.1021/jm00043a020
164611656 191516 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4850726 191516 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1067 27 14 12 0.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1016/j.bmcl.2021.128086
44348408 120350 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
CHEMBL332239 120350 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm00075a033
10055096 105061 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
CHEMBL274712 105061 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 656 15 1 7 7.3 CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 10.1021/jm00043a020
10054188 214300 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL94582 214300 0 None - 0 Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 592 9 1 7 5.1 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 10.1021/jm00043a020
9939191 105722 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL279629 105722 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL97539 105722 1 None - 1 Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
9829012 99331 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL24322 99331 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9829012 99331 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
CHEMBL24322 99331 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membraneDisplacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)80517-5
44376781 63046 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL162859 63046 0 None - 0 Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 517 10 2 6 4.8 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
9829012 99331 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
CHEMBL24322 99331 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against angiotensin II receptor, type 2Inhibitory concentration against angiotensin II receptor, type 2
ChEMBL 550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm058225d
9895635 118800 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
CHEMBL328941 118800 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 10.1021/jm00043a020
10484119 174887 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
CHEMBL432822 174887 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 628 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 10.1021/jm00043a020
10075750 114335 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL318891 114335 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 532 10 1 7 4.8 CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44323291 213320 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL88600 213320 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.4 CCCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10095637 56741 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15689 56741 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
10009735 164984 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408798 164984 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 676 3 1 7 6.9 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 10.1016/0960-894X(96)00116-3
10004112 32302 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
CHEMBL135089 32302 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 454 9 1 5 5.5 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 10.1021/jm9504722
44311683 112395 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL312301 112395 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311618 170116 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL419073 170116 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311581 174612 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL430792 174612 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311415 210864 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70161 210864 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311582 210987 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70868 210987 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44321790 213391 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89052 213391 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 634 13 4 8 4.9 C=CC(O)(C(=O)O)c1c(SC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381656 127046 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352458 127046 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44330904 11118 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
CHEMBL101039 11118 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 698 19 1 8 7.3 CCCC(=O)N(CCC)CCC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1021/jm00015a016
10373120 124379 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
CHEMBL340078 124379 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F 10.1021/jm00019a004
15284887 172259 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
CHEMBL424004 172259 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 607 6 2 5 4.7 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc(I)c1O 10.1016/S0960-894X(00)80690-3
44381427 127051 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL352503 127051 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10259525 22391 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL122158 22391 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9987614 175352 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL435792 175352 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44321823 212998 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL86617 212998 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 696 13 4 8 6.1 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1 10.1016/0960-894X(95)00479-D
19939753 210533 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL67921 210533 0 None - 0 Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 10.1016/S0960-894X(01)81115-X
10100951 121822 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
CHEMBL334300 121822 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm00019a004
44371045 126589 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL348363 126589 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 4 6.0 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
10344854 64379 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
CHEMBL1668009 64379 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 474 7 2 6 5.2 CCCCc1nc(Cl)c2n1C(c1ccc(-c3ccccc3-c3nnn[nH]3)cc1)CC=C2C(=O)O 10.1016/j.bmc.2010.10.043
10053595 109893 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL307756 109893 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 562 10 2 8 4.8 CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311638 109702 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL306186 109702 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 613 18 1 8 6.7 CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
44303230 207426 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59957 207426 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)80554-0
44303232 209494 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
CHEMBL61754 209494 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 434 8 1 6 4.8 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Cl 10.1016/S0960-894X(01)80554-0
44311636 210908 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL70389 210908 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 549 9 2 9 3.8 CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222103 211318 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72819 211318 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 678 12 2 9 5.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(00)80076-1
44376746 126637 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL348758 126637 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 568 16 2 7 5.9 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 10.1016/S0960-894X(01)81124-0
44303230 207426 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL59957 207426 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
11764669 73594 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL18606 73594 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 6.5 CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10233056 113936 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
CHEMBL316297 113936 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 637 10 1 8 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 10.1021/jm00043a020
10009478 119249 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
CHEMBL329858 119249 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 10.1021/jm00043a020
10032361 119503 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
CHEMBL330463 119503 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 10.1021/jm00043a020
10100723 214227 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL94176 214227 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 646 9 1 7 6.1 CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
44303230 207426 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
CHEMBL59957 207426 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 515 10 1 6 5.0 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm9504722
11741658 25585 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL127844 25585 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 399 4 0 3 4.3 COC(=O)C1Cc2c(C)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
108185 8395 78 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
586 8395 78 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
CHEMBL907 8395 78 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 436 8 2 6 4.5 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl 10.1021/jm00050a002
1610 9126 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3941 9126 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
3961 9126 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
590 9126 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
CHEMBL191 9126 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
DB00678 9126 95 None - 4 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00050a002
183134 211623 17 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
CHEMBL7550 211623 17 None - 1 Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity for angiotensin II AT2 receptor in rat midbrainIn vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00050a002
44475943 195487 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL504492 195487 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1508 12 8 32 4.9 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCOCC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
44309703 179333 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
CHEMBL448476 179333 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(01)81115-X
10417031 114163 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
CHEMBL317864 114163 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 669 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 10.1021/jm00043a020
9986951 214546 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
CHEMBL95955 214546 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 10.1021/jm00043a020
10416422 214778 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL97295 214778 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 620 9 1 7 5.8 CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
10416836 114681 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
CHEMBL319313 114681 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 651 11 1 8 6.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm00043a020
9888876 55764 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
CHEMBL15606 55764 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 10.1016/0960-894X(95)00185-V
73353934 99397 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
CHEMBL2435824 99397 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 10.1016/j.ejmech.2013.08.014
10372093 119539 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
CHEMBL330533 119539 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 10.1021/jm00043a020
44376822 126831 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL350493 126831 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 565 10 1 7 5.5 CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
44274823 105851 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
CHEMBL280526 105851 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
Binding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against Angiotensin II receptor type 2 from rat mid brain using [125I]-Sar1-Ile8-Ang II without BSA
ChEMBL 551 10 2 8 5.8 CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00073a024
9830839 113708 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
CHEMBL314812 113708 0 None - 2 Rat 6.3 pIC50 = 6.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 640 10 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 10.1021/jm00043a020
44379183 127593 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL355708 127593 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 571 10 1 6 6.2 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1016/S0960-894X(01)81125-2
11758341 124061 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
CHEMBL339544 124061 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 603 13 1 7 6.5 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 10.1021/jm00019a005
10326942 119171 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
CHEMBL329693 119171 0 None - 0 Rat 7.3 pIC50 = 7.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 10.1021/jm00043a020
10100074 119337 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL330007 119337 0 None - 0 Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 598 9 1 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 10.1021/jm00043a020
44379184 64223 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL165541 64223 0 None - 0 Rat 6.3 pIC50 = 6.3 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 602 14 2 7 5.9 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 10.1016/S0960-894X(01)81125-2
44323351 113797 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL315401 113797 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 635 11 1 9 6.6 CCCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3Cl)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
10394829 126138 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344387 126138 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
10485202 126198 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL344811 126198 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
9873751 103195 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL261981 103195 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 614 12 1 8 5.9 CCCCc1nc2ccn(C(C(=O)N(CC)CC)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323290 113677 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL314603 113677 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 587 10 1 9 5.6 CCCc1nc2ccn(C(C(=O)OC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44381431 65275 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL168346 65275 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 578 11 1 9 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10078452 114055 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
CHEMBL317061 114055 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1021/jm00043a020
44377123 126753 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349856 126753 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 481 10 2 6 3.9 CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
10391038 123710 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
CHEMBL338514 123710 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 494 13 0 6 5.3 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 10.1021/jm00019a005
44309701 109963 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
CHEMBL308238 109963 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 609 11 2 7 6.3 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C 10.1016/S0960-894X(01)81115-X
15230312 55688 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155987 55688 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 507 8 1 4 5.4 COc1cc2c(cc1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
164620345 192992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4873167 192992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10054324 105129 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
CHEMBL275160 105129 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 600 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm00043a020
9908300 22318 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
CHEMBL12190 22318 0 None - 0 Rat 4.2 pIC50 = 4.2 Binding
Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membraneActivity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]angiotensin II binding to rat uterine membrane
ChEMBL 387 8 2 5 3.9 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-n2cccc2C(=O)O)cc1 10.1021/jm00053a013
73357016 99398 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435825 99398 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 503 8 2 4 7.0 CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL408773 219510 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)CSS2 10.1021/jm00065a013
10462933 23654 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL125008 23654 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
9850834 161441 17 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
CHEMBL39959 161441 17 None - 1 Human 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm9504722
9874508 211459 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL73876 211459 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44210586 65786 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169221 65786 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10101690 123639 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
CHEMBL338137 123639 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F 10.1021/jm00019a004
10395394 38654 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL140708 38654 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44314780 109855 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL307430 109855 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 649 11 3 8 5.6 CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
10010207 36968 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
CHEMBL139041 36968 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparationIn vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid brain AT2 receptor preparation
ChEMBL 735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm00052a006
44315180 109673 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL305956 109673 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membraneIn vivo inhibitory concentration against Angiotensin II, type 2 of rat midbrain membrane
ChEMBL 621 9 2 8 4.9 Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
19763341 68759 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
CHEMBL177435 68759 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 448 8 1 6 5.2 CCCc1nc(-c2ccccc2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00137a004
5311345 9795 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
597 9795 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
CHEMBL321820 9795 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptorIn vitro binding affinity of compound was measured against angiotensin II (AT2) receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)80517-5
5311345 9795 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
597 9795 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
CHEMBL321820 9795 46 None 10 2 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(01)81122-7
9804437 124843 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340467 124843 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 463 6 1 3 5.6 O=C(O)C1Cc2cc(Oc3ccccc3)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
9915892 110395 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308703 110395 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10417351 214737 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
CHEMBL97075 214737 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 10.1021/jm00043a020
9895984 211528 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
CHEMBL74476 211528 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 10.1016/0960-894X(94)85036-4
9915892 110395 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
CHEMBL308703 110395 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 563 10 2 9 4.1 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm9504722
19385644 105527 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL278061 105527 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 519 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 10.1016/0960-894X(95)00185-V
44311429 211395 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
CHEMBL73369 211395 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 649 11 1 8 6.8 CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80077-3
10318033 125051 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340933 125051 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 387 4 2 3 3.6 O=C(O)C1Cc2cc(O)ccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311342 108958 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL302760 108958 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 611 12 3 7 5.9 CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222094 109751 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306489 109751 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 596 10 2 8 5.4 CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222101 165341 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL409170 165341 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 642 12 2 9 4.2 CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(00)80076-1
44311688 110973 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309820 110973 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 554 10 2 8 3.5 CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
14952909 154854 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
CHEMBL39349 154854 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 424 10 2 5 4.7 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1C(=O)O 10.1021/jm00108a043
73357018 99407 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435834 99407 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 8 2 4 7.3 CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
19385598 105638 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
CHEMBL278955 105638 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 457 8 1 6 5.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 10.1016/0960-894X(95)00185-V
44379291 127294 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL354535 127294 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 702 15 2 8 7.5 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)81125-2
14952916 106922 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
CHEMBL287762 106922 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 425 10 1 6 5.0 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc([N+](=O)[O-])cc1 10.1021/jm00108a043
44384872 66769 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL173455 66769 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 575 9 3 7 4.4 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 10.1016/0960-894X(96)00116-3
CHEMBL440063 220636 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC)CSSC[C@H](C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44315349 67164 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL17487 67164 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 10 2 9 5.1 CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315350 111995 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL311484 111995 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 645 9 3 7 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10259334 214817 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
CHEMBL97500 214817 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 724 13 1 10 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00043a020
114899 9794 15 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
596 9794 15 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
CHEMBL1188080 9794 15 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity against angiotensin II AT-2 receptorIn vitro binding affinity against angiotensin II AT-2 receptor
ChEMBL 480 6 2 5 4.0 OC(=O)C1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N 10.1021/jm00137a004
5311348 107449 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
CHEMBL292277 107449 4 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 480 6 2 5 4.0 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N 10.1021/jm9504722
44379086 63352 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL164174 63352 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 543 9 1 6 5.4 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81125-2
44311074 111677 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL311253 111677 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
9938088 109258 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
CHEMBL304022 109258 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1016/S0960-894X(01)80554-0
9851889 108851 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL302102 108851 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 611 12 1 7 7.1 CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 10.1016/0960-894X(94)85036-4
44303883 209681 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62744 209681 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 634 11 1 3 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
9938088 109258 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
CHEMBL304022 109258 0 None - 0 Rat 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.Inhibition of [125I]-[Sar1,Ile8]Ang II binding at rat angiotensin II (type 2) receptor.
ChEMBL 575 12 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OC)c(Cl)c1 10.1021/jm00015a016
44382994 103679 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL265790 103679 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 933 25 7 10 5.8 Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1NCCCCCCNC(=O)[C@@H](N)CCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 10.1016/S0960-894X(00)80690-3
CHEMBL384125 219096 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44381657 65832 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169488 65832 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 10.1016/S0960-894X(01)81126-4
10372550 171295 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL421478 171295 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 698 13 1 9 7.5 CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
44314823 168665 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
CHEMBL415073 168665 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 10.1016/0960-894X(94)85036-4
44314822 109726 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL306362 109726 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F 10.1016/0960-894X(94)85036-4
44303885 209682 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62754 209682 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 538 12 1 4 5.8 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(OC)c2)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10413312 124089 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
CHEMBL339706 124089 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 6 1 3 5.8 COc1ccc(-c2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm00077a001
10344278 124961 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 124961 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44323559 213790 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL91465 213790 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 628 10 1 9 4.9 CCCCc1nc2ccn(C(C(=O)N3CCOCC3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44311451 110879 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309367 110879 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 576 10 2 8 5.1 CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
18655106 207248 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
CHEMBL59854 207248 0 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 464 10 0 2 6.4 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 10.1016/S0960-894X(01)81007-6
15296723 55639 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155938 55639 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 499 7 1 4 5.2 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)Cc1c(Cl)cccc1Cl)C2 10.1016/S0960-894X(01)81122-7
14403498 107808 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
CHEMBL294558 107808 3 None - 0 Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 495 7 1 5 4.4 COc1ccc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1C 10.1021/jm9504722
164612059 191280 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
CHEMBL4847398 191280 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1123 30 14 12 1.6 CCCC[C@@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2[nH]c3ccccc3c2C[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](C)CC)C1=O 10.1016/j.bmcl.2021.128086
44303614 207446 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL59974 207446 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 478 8 1 6 4.9 CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
15222070 109074 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL303426 109074 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 9 2 9 3.8 CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44311648 211306 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL72721 211306 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 577 11 2 9 4.5 CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
10349256 118233 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
CHEMBL327569 118233 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 647 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 10.1021/jm00043a020
10461595 214899 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
CHEMBL97964 214899 0 None - 0 Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 10.1021/jm00043a020
10254358 124273 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340018 124273 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 475 6 0 3 5.5 COC(=O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311472 110569 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308943 110569 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 669 14 3 8 5.7 CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44377199 64193 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165349 64193 0 None - 0 Rat 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 531 10 2 6 4.9 CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
73353933 99394 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435821 99394 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 554 11 2 6 5.2 CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
10078132 114028 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
CHEMBL316904 114028 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 10.1021/jm00043a020
10078048 113657 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
CHEMBL314514 113657 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 12 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 10.1021/jm00043a020
10411441 58564 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL15850 58564 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 449 7 1 5 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
15230316 126870 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
CHEMBL350875 126870 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 522 7 1 6 5.3 COC(=O)C1Cc2c(ccc(OC)c2Oc2ccc(N)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1 10.1016/S0960-894X(01)81122-7
44348259 22804 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
CHEMBL122367 22804 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 575 12 1 5 8.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 10.1021/jm00075a033
1610 9126 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3941 9126 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
3961 9126 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
590 9126 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
CHEMBL191 9126 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
DB00678 9126 95 None - 4 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 2 in rat midbrain membrane preparations.
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00019a004
1610 9126 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3941 9126 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
3961 9126 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
590 9126 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
CHEMBL191 9126 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
DB00678 9126 95 None - 4 Rat 4.1 pIC50 = 4.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm00043a020
10393837 174723 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
CHEMBL431619 174723 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 602 10 1 8 5.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 10.1021/jm00043a020
44211672 164985 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
CHEMBL408799 164985 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2Inhibition of [125I]-Sar1-Ile8-Ang II binding to rat midbrain Angiotensin II receptor type 2
ChEMBL 706 4 1 8 7.4 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 10.1016/0960-894X(96)00116-3
9892451 55514 23 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
CHEMBL155836 55514 23 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of rat AT2 receptorInhibition of rat AT2 receptor
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1021/acs.jmedchem.9b01780
15296726 58645 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL158557 58645 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 551 9 2 5 5.1 COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
18950598 22314 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
CHEMBL121891 22314 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C 10.1021/jm00075a033
10483888 118232 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
CHEMBL327563 118232 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 10.1021/jm00043a020
18950607 57192 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
CHEMBL15729 57192 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 489 9 1 5 6.2 C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00185-V
9933755 61820 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
CHEMBL16165 61820 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 456 9 1 5 5.3 CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 10.1016/0960-894X(95)00185-V
73355475 99400 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435827 99400 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 517 9 2 4 6.9 CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
9807029 209883 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL63998 209883 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1016/S0960-894X(01)80554-0
9807029 209883 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
CHEMBL63998 209883 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of Angiotensin II receptor, type 2Inhibition of Angiotensin II receptor, type 2
ChEMBL 530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 10.1021/jm9504722
73347892 99396 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
CHEMBL2435823 99396 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT2 receptor (unknown origin) after 180 mins by gamma counting analysis
ChEMBL 455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1016/j.ejmech.2013.08.014
25135102 195649 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL507053 195649 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1495 12 10 32 3.6 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(O)c(-c3nc(C(=O)NCCNC(=O)CN(C)C)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
10349801 114715 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
CHEMBL319353 114715 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 10.1021/jm00043a020
19385586 56500 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
CHEMBL15669 56500 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 479 8 1 6 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 10.1016/0960-894X(95)00185-V
10414470 23901 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
CHEMBL125542 23901 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
The compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligandThe compound was tested for binding affinity against Angiotensin II receptor, type 2 from rabbit uterus membrane by using [125I]AngII as radioligand
ChEMBL 524 11 2 7 4.8 CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00019a005
44322176 213456 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL89463 213456 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 646 13 3 11 4.4 CCCCc1nc(SC)c(C(O)n2cnnn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
44381622 65795 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL169279 65795 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 10.1016/S0960-894X(01)81126-4
44315078 211535 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74556 211535 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
19102815 214657 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
CHEMBL96554 214657 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrainIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
ChEMBL 672 11 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1016/S0960-894X(01)80595-3
44321775 113776 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL315275 113776 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 588 13 4 8 4.4 CCCCc1nc(SC)c(C(C)(O)C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
10439858 23633 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
CHEMBL124903 23633 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.
ChEMBL 719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 10.1021/jm00019a004
5311345 9795 46 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
597 9795 46 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
CHEMBL321820 9795 46 None 10 2 Human 8.1 pIC50 = 8.1 Binding
The compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptorThe compound was evaluated for the inhibition of binding of [125I]-CGP 42112A to AT2 receptor
ChEMBL 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 10.1016/S0960-894X(00)80690-3
44381670 127262 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
CHEMBL354298 127262 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
In vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membraneIn vitro for binding affinity against angiotensin II receptor type 2 in rat midbrain membrane
ChEMBL 657 11 3 9 6.0 CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 10.1016/S0960-894X(01)81126-4
44315282 103399 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
CHEMBL263452 103399 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 10.1016/0960-894X(94)85036-4
10344278 124961 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 124961 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44303211 107374 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
CHEMBL291803 107374 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomesCompound was tested for the inhibition of angiotensin II AT2 receptor by displacement of [125I]- Ang II to rat adrenal cortical microsomes
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1016/S0960-894X(01)80554-0
44303404 206485 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL59331 206485 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(C)=O)cc1 10.1016/S0960-894X(01)80554-0
CHEMBL264450 217398 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CCSSCC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
44311498 109707 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL306216 109707 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 580 10 2 8 4.9 CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
15222092 110601 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL309165 110601 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 564 10 2 10 3.5 CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44379182 64896 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL167662 64896 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 593 10 1 6 6.7 CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81125-2
9961192 18138 43 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL1179743 18138 43 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
CHEMBL97688 18138 43 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 654 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 10.1021/jm00043a020
10417102 214225 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
CHEMBL94145 214225 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 10.1021/jm00043a020
44303211 107374 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
CHEMBL291803 107374 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity at Angiotensin II type 2 receptor.Inhibitory activity at Angiotensin II type 2 receptor.
ChEMBL 584 8 2 6 5.8 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1Br 10.1021/jm9504722
18950608 22443 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
CHEMBL122224 22443 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptorDisplacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor
ChEMBL 513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 10.1021/jm00075a033
44311568 104960 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL273992 104960 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 607 13 2 8 6.2 CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80076-1
44270367 170002 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
CHEMBL418354 170002 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 505 9 1 5 6.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 10.1016/0960-894X(95)00185-V
44377111 126662 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL349020 126662 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 495 10 1 7 3.9 CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 10.1016/S0960-894X(01)81124-0
44210830 64257 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
CHEMBL165850 64257 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Binding affinity to AT2 receptor in rat midbrain binding assayBinding affinity to AT2 receptor in rat midbrain binding assay
ChEMBL 461 6 1 6 5.9 CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 10.1016/S0960-894X(01)80193-1
10054708 113931 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
CHEMBL316273 113931 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 10.1021/jm00043a020
44304163 209564 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
CHEMBL62157 209564 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Inhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assayInhibition of Angiotensin II receptor, type 2 in rat midbrain using [125I]-Sar1,Ile8 angiotensin II binding assay
ChEMBL 496 17 1 3 5.7 CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(CCCCC)CCCCC)[C@H](C(=O)O)C1 10.1016/S0960-894X(01)81007-6
10350378 214978 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
CHEMBL98453 214978 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 10.1021/jm00043a020
44574325 195529 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL505204 195529 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of AT2 receptorInhibition of AT2 receptor
ChEMBL 1521 12 8 32 4.8 CO/C(C)=C1/NC(=O)[C@H]([C@@H](C)O)NC(=O)c2csc(n2)-c2cc(OC)c(-c3nc(C(=O)NCCCN4CCN(C)CC4)cs3)nc2-c2csc(n2)[C@@H]2COC(=O)c3c4c5c(cccc5n3O)COC(=O)[C@@H](O[C@H]3C[C@](C)(O)[C@H](N(C)C)[C@H](C)O3)[C@@H](OC4)[C@H](NC(=O)c3csc1n3)c1nc(cs1)C(=O)N2 10.1016/j.bmcl.2009.04.144
CHEMBL413034 219827 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
9874086 115890 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
CHEMBL321367 115890 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 10.1021/jm00043a020
19939756 11810 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL105199 11810 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
10349845 18134 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL1179731 18134 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
CHEMBL97271 18134 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 708 10 1 8 7.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 10.1021/jm00043a020
164627947 193164 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
CHEMBL4875696 193164 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysisDisplacement of [125-I]-[Sar1, Ile8] from recombinant human AT2R transfected in human HEK293 cells incubated for 2 hrs by liquid scintillation counter analysis
ChEMBL 1084 26 13 13 0.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2021.128086
10426066 107284 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
CHEMBL291114 107284 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
ChEMBL 318 7 1 3 4.0 CCCCc1ncc(/C=C/C(=O)O)n1Cc1ccccc1Cl 10.1021/jm00108a043
44311454 109722 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL306340 109722 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44311436 210967 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
CHEMBL70793 210967 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity for angiotensin II AT-2 receptorBinding affinity for angiotensin II AT-2 receptor
ChEMBL 725 15 1 8 8.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/S0960-894X(00)80077-3
44303420 208522 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
CHEMBL60661 208522 0 None - 0 Rat 8.1 pIC50 = 8.1 Binding
Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomesDisplacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes
ChEMBL 525 12 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C=O)c(C)c1 10.1016/S0960-894X(01)80554-0
44321804 112757 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL313073 112757 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 690 13 4 8 5.7 CCCCc1nc(SC)c(C(O)(C(=O)O)C(F)(F)F)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCc2ccccc2)cc1 10.1016/0960-894X(95)00479-D
CHEMBL406290 219382 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.
ChEMBL None None None CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]1CCSS[C@H]2C[C@@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00065a013
15292111 211524 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL74442 211524 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F 10.1016/0960-894X(94)85036-4
44315304 211789 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
CHEMBL76821 211789 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F 10.1016/0960-894X(94)85036-4
15230313 55388 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
CHEMBL155728 55388 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.
ChEMBL 446 6 1 4 4.3 COc1ccc2c(c1OCc1ccccc1)CC(C(=O)O)N(C(=O)N(C)c1ccccc1)C2 10.1016/S0960-894X(01)81122-7
15292112 109725 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
CHEMBL306361 109725 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
In vivo inhibitory concentration against AT2 receptor of human adrenal membraneIn vivo inhibitory concentration against AT2 receptor of human adrenal membrane
ChEMBL 635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 10.1016/0960-894X(94)85036-4
10368357 124049 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
CHEMBL339485 124049 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 491 7 1 3 5.5 COc1ccc(Cc2cccc3c2CC(C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)cc1 10.1021/jm00077a001
10344278 124961 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
CHEMBL340902 124961 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
Binding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomesBinding affinity towards Angiotensin II receptor, type 2 in rat isolated adrenal medullary microsomes
ChEMBL 461 6 1 2 5.4 O=C(O)C1Cc2c(Cc3ccccc3)cccc2CN1C(=O)C(c1ccccc1)c1ccccc1 10.1021/jm00077a001
44311739 109384 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
CHEMBL304137 109384 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 563 14 2 7 6.2 CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O 10.1016/S0960-894X(00)80076-1
44311662 109458 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
CHEMBL304620 109458 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 624 17 2 7 5.8 CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC 10.1016/S0960-894X(00)80076-1
44311650 109978 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
CHEMBL308361 109978 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
ChEMBL 674 14 2 10 5.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 10.1016/S0960-894X(00)80076-1
14952904 106940 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
CHEMBL287936 106940 0 None - 0 Rat 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards angiotensin II receptor in rat mesenteric membranes.
ChEMBL 396 9 2 5 4.8 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1O 10.1021/jm00108a043
44309704 211057 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
CHEMBL71253 211057 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes
ChEMBL 612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C 10.1016/S0960-894X(01)81115-X
44300798 205734 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
CHEMBL58499 205734 0 None - 0 Rat 6.1 pIC50 = 6.1 Binding
Inhibition of rat midbrain angiotensin II type 2 receptorInhibition of rat midbrain angiotensin II type 2 receptor
ChEMBL 558 8 1 7 6.1 CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 10.1016/S0960-894X(01)81145-8
9805344 105816 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
CHEMBL280290 105816 0 None - 0 Rat 5.1 pIC50 = 5.1 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 483 7 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 10.1016/0960-894X(95)00185-V
10372718 115334 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
CHEMBL320222 115334 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII
ChEMBL 722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl 10.1021/jm00043a020
9809280 211751 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL76525 211751 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
CHEMBL80370 211751 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]AII displacement.
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1016/0960-894X(95)00479-D
9809280 211751 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL76525 211751 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
CHEMBL80370 211751 10 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against Angiotensin II receptor, type 2Inhibitory activity was evaluated against Angiotensin II receptor, type 2
ChEMBL 544 12 3 7 4.8 CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1 10.1021/jm9504722
19385623 57209 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
CHEMBL15730 57209 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
ChEMBL 429 7 1 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 10.1016/0960-894X(95)00185-V
44335530 114286 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
CHEMBL318605 114286 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2Compound was evaluated for inhibition of 125I[Sar1,Ile8] aII binding to rat midbrain membrane preparation Angiotensin II receptor, type 2
ChEMBL 520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/0960-894X(96)00017-0
44323292 170581 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL420607 170581 0 None - 0 Rat 7.0 pIC50 = 7.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 615 12 1 9 6.2 CCCCc1nc2ccn(C(C(=O)OCC(C)C)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44323363 118383 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
CHEMBL328340 118383 0 None - 0 Rat 6.0 pIC50 = 6.0 Binding
In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparationIn vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
ChEMBL 558 10 2 8 4.5 CCCCc1nc2ccn(C(C(N)=O)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/0960-894X(95)00477-B
44379185 64328 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
CHEMBL166428 64328 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrainIn vitro displacement of 125I-[Sar1, Ile8] from AT2 receptors in rat midbrain
ChEMBL 603 13 2 7 5.6 CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 10.1016/S0960-894X(01)81125-2
19742811 64195 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
CHEMBL165354 64195 0 None - 0 Rat 5.0 pIC50 = 5.0 Binding
In vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrainIn vitro inhibitory activity against angiotensin II (AT2) receptor to displace 125I-Sar,Ile8-AII in rat midbrain
ChEMBL 551 10 2 6 5.4 CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1016/S0960-894X(01)81124-0
56661223 70026 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 70026 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL2392353 217193 6 None - 1 Human 10.0 pKi = 10.0 Binding
Binding affinity to human AT2 receptor by radioligand displacement assayBinding affinity to human AT2 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10079601 219310 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
CHEMBL404594 219310 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1021/ml500278g
10079601 219310 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL404594 219310 14 None 4 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL938 222686 28 None -1 2 Human 9.8 pKi = 9.8 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/jm8007618
CHEMBL216061 216095 15 None -1 2 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16133225 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
172198 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
2504 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
45266664 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
5272 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
CHEMBL408403 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
DB11842 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None None 10.1021/jm050280z
16133225 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
172198 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
2504 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
45266664 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
5272 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
CHEMBL408403 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
DB11842 7207 52 None 1 5 Human 9.7 pKi = 9.7 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None None 10.1016/j.bmcl.2015.10.084
16133225 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
172198 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
2504 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
45266664 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
5272 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
CHEMBL408403 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
DB11842 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None None 10.1021/jm030921v
16133225 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
172198 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
2504 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
45266664 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
5272 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
CHEMBL408403 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
DB11842 7207 52 None 1 5 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None None 10.1021/jm0491492
56661223 70026 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791308 70026 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
16133225 7207 52 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
172198 7207 52 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
2504 7207 52 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
45266664 7207 52 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
5272 7207 52 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL408403 7207 52 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
DB11842 7207 52 None 1 5 Human 9.5 pKi = 9.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None None 10.1021/jm0613469
CHEMBL938 222686 28 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1021/ml500278g
CHEMBL938 222686 28 None -1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C 10.1016/j.bmcl.2015.10.084
6918 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
9804984 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
CHEMBL189568 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptorBinding affinity to AT2 receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2010.03.064
6918 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
6918 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
9804984 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
9804984 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
CHEMBL189568 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/acs.jmedchem.8b00294
CHEMBL189568 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/ml500278g
6918 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
9804984 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
CHEMBL189568 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2015.10.084
6918 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
9804984 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
CHEMBL189568 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1021/jm049715t
11317806 130420 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
CHEMBL361927 130420 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 489 10 1 7 5.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 10.1021/jm049715t
11994291 87503 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL215160 87503 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 485 12 1 7 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11994289 89252 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217673 89252 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
16133225 7207 52 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
172198 7207 52 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
2504 7207 52 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
45266664 7207 52 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
5272 7207 52 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL408403 7207 52 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
DB11842 7207 52 None 1 5 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None None 10.1021/jm051222g
CHEMBL404996 219318 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CCSC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
CHEMBL3350599 218260 0 None - 1 Human 9.2 pKi = 9.2 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
11994289 89252 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL217673 89252 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/acs.jmedchem.5b00982
11994289 89252 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL217673 89252 0 None 1 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmcl.2015.10.084
CHEMBL268815 217545 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm051222g
10463891 103689 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL265881 103689 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL268815 217545 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm0491492
CHEMBL424755 220103 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O 10.1021/jm0613469
44398242 73990 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL187880 73990 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
10163396 88353 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216250 88353 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 489 12 1 7 4.5 CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL5286105 201110 0 None - 1 Rat 9.0 pKi = 9 Binding
Displacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 1073 26 13 14 -1.2 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H]1SC[C@H]2C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2022.128983
168283461 197762 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5186237 197762 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 10 1 8 4.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
16133225 7207 52 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
172198 7207 52 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
2504 7207 52 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
45266664 7207 52 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
5272 7207 52 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
CHEMBL408403 7207 52 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
DB11842 7207 52 None 1 5 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None None 10.1021/jm049651m
CHEMBL5274111 200574 0 None -1 2 Rat 8.9 pKi = 8.9 Binding
Displacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 1060 30 14 13 -0.7 CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.bmcl.2022.128983
168273584 196992 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5174659 196992 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 503 8 1 10 4.2 CCCc1nc(-c2ccc(Cn3ccnc3-c3nccs3)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL268815 217545 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
9850834 161441 17 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL39959 161441 17 None - 1 Human 8.8 pKi = 8.8 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 562 11 1 7 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
16087342 148491 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL385706 148491 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1149 28 13 14 0.8 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
11564291 173873 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL428986 173873 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1008 26 12 12 -0.1 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
10160913 148585 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386269 148585 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11766283 78355 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL196316 78355 0 None - 1 Human 8.0 pKi = 8 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 909 23 11 11 -0.2 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
168270996 196838 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5172324 196838 0 None 64 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 533 11 1 6 6.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168291545 198769 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
CHEMBL5201369 198769 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 597 10 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1cc(F)c(Cn2c(C(C)(C)C)nc3ccccc32)c(F)c1 10.1016/j.bmc.2022.116804
162660565 188101 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4762752 188101 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 9 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL426885 220130 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)O 10.1021/jm0613469
56657702 70027 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 70027 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168290795 198726 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5200734 198726 0 None 33 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 559 11 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168292515 198818 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
CHEMBL5202149 198818 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2cc(F)c(Cn3c(C(C)(C)C)nc4ccccc43)c(F)c2)c1 10.1016/j.bmc.2022.116804
118725967 123976 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394207 123976 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
118725967 123976 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL3394207 123976 0 None - 1 Human 7.9 pKi = 7.9 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
168274956 197117 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176607 197117 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 10 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(F)(F)F)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10227337 88431 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216361 88431 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168296606 199227 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5208437 199227 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 587 11 1 6 8.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145963801 170840 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4209214 170840 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11365721 105443 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
CHEMBL277388 105443 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 640 13 1 10 6.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 10.1021/jm031031i
168287840 198085 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5191241 198085 0 None 32 2 Human 7.9 pKi = 7.9 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 12 1 6 6.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145978135 170668 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4207027 170668 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 9 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCC2CC2)s1 10.1016/j.bmcl.2017.11.042
168295859 199064 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205969 199064 0 None -50 2 Human 5.9 pKi = 5.9 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 569 11 1 9 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
168288075 198441 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5196244 198441 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 595 12 1 6 7.5 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(Cc3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11994292 88761 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216515 88761 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 471 10 1 7 4.6 CCCCOC(=O)NS(=O)(=O)c1ccc(OC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168285844 198348 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5194914 198348 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 462 8 1 8 4.2 CCCc1nc(-c2ccc(Cn3ccnc3C(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
44420775 144662 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
CHEMBL376286 144662 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 315 7 2 4 2.2 CC[C@@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1021/jm0613469
145965121 171205 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4213607 171205 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1016/j.bmcl.2017.11.042
11296725 107150 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289803 107150 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 652 13 2 9 6.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(C)=O)cc3c2=O)cc1 10.1021/jm031031i
9830680 107419 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
CHEMBL292150 107419 0 None - 1 Rat 7.8 pKi = 7.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 10.1021/jm990504b
162657895 187838 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4759641 187838 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 12 1 8 6.0 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)C)c1 10.1016/j.bmc.2020.115859
56964910 84219 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
CHEMBL2086892 84219 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to AT2 receptor (unknown origin)Binding affinity to AT2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1021/ml500278g
56964910 84219 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
CHEMBL2086892 84219 0 None - 1 Human 7.8 pKi = 7.8 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2015.10.084
162675267 190136 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4797684 190136 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 501 8 1 7 4.8 CC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11764788 107635 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
CHEMBL293501 107635 0 None - 1 Rat 6.8 pKi = 6.8 Binding
Binding affinity to Angiotensin II receptor, type 2Binding affinity to Angiotensin II receptor, type 2
ChEMBL 645 11 1 9 5.8 CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 10.1021/jm990504b
158303357 199011 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205106 199011 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 532 10 1 8 5.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
166492461 198591 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5198482 198591 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 474 8 1 8 4.2 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145977406 170627 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4206507 170627 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 487 8 1 7 5.2 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC2CCCC2)s1 10.1016/j.bmcl.2017.11.042
73213176 111478 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105392 111478 0 None - 1 Human 4.8 pKi = 4.8 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 454 9 2 6 2.6 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NS(=O)(=O)c1ccccc1 10.1016/j.bmcl.2013.12.040
11995658 88913 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
CHEMBL216746 88913 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 364 6 1 6 4.0 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(-c2nn[nH]n2)s1 10.1021/jm0606185
168274734 197445 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5181652 197445 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 12 1 6 7.1 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492455 198188 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
CHEMBL5192639 198188 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 7 1 8 4.4 CCCc1nc(-c2ccc(Cn3ccnc3C(C)(C)C)cc2)c(S(=O)(=O)NC(=O)OC)s1 10.1016/j.bmc.2022.116790
3936 8991 35 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
6603900 8991 35 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
CHEMBL288174 8991 35 None -2 4 Human 8.7 pKi = 8.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)Displacement of 125I-[Sar1,Ile8]ANGII form AT2 receptor (unknown origin)
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1016/j.bmc.2022.116790
11994290 87175 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL214525 87175 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 441 9 1 6 4.4 CCCCc1ccc(S(=O)(=O)NC(=O)OCC)c(-c2ccc(Cn3ccnc3)cc2)c1 10.1021/jm0606185
CHEMBL268815 217545 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm030921v
10031067 107128 4 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL289614 107128 4 None -2 3 Human 8.7 pKi = 8.7 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 576 11 1 7 6.7 CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/acs.jmedchem.5b00982
CHEMBL216331 216102 0 None - 1 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL None None None NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm049651m
56657702 70027 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
CHEMBL1791309 70027 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cccc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)c2N[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm0491492
168277309 197007 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5174923 197007 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 448 8 1 8 3.7 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
3936 8991 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
6603900 8991 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
CHEMBL288174 8991 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm031031i
44400670 165671 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL409528 165671 0 None - 1 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 993 23 12 13 -0.7 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
3936 8991 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
6603900 8991 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
CHEMBL288174 8991 35 None -2 4 Human 8.6 pKi = 8.6 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 582 11 1 8 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C 10.1021/jm049715t
168277868 197256 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178914 197256 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 10 1 8 4.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2)cc1 10.1016/j.bmc.2022.116790
145978497 170433 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4204342 170433 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 10 1 7 5.3 CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972310 171346 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215292 171346 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 9 1 6 4.6 CCN(CC)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
45102601 176350 12 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
CHEMBL4435800 176350 12 None -1995 2 Human 5.6 pKi = 5.6 Binding
Displacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIADisplacement of Europium-labeled angiotensin-2 from human AT2 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIA
ChEMBL 527 12 3 6 5.4 CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F 10.1021/acsmedchemlett.8b00462
162651258 187114 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4751226 187114 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 545 13 1 8 5.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCC)c1 10.1016/j.bmc.2020.115859
166492466 198721 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5200682 198721 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 476 8 1 8 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
56964910 84219 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086892 84219 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
56964910 84219 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL2086892 84219 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145967796 171612 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4218765 171612 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1016/j.bmcl.2017.11.042
67132863 84222 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
CHEMBL2086910 84222 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 503 11 1 8 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2)c1 10.1016/j.bmc.2020.115859
145976243 170305 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4202730 170305 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 473 11 1 6 5.2 CCCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
163408877 197478 3 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5182186 197478 3 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 490 7 1 8 4.6 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
168277087 197265 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5179052 197265 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 505 10 1 6 5.9 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1016/j.bmc.2022.116804
145969149 171548 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217991 171548 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 461 9 1 7 4.7 CCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
73213178 111479 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105394 111479 0 None - 1 Human 4.5 pKi = 4.5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 483 10 3 6 2.4 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2013.12.040
10057017 168606 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
CHEMBL414478 168606 0 None - 1 Human 8.5 pKi = 8.5 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm030921v
10057017 168606 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
CHEMBL414478 168606 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1093 26 13 14 -0.6 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1ccc2c(c1)CN(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(=O)[C@H](Cc1ccc(O)cc1)N2 10.1021/jm0491492
168272246 197271 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179119 197271 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 477 10 1 8 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cc2ncco2)cc1 10.1016/j.bmc.2022.116790
10196520 74418 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
CHEMBL190577 74418 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 553 11 1 7 6.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 10.1021/jm049715t
6918 7815 35 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
9804984 7815 35 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
CHEMBL189568 7815 35 None -3 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmc.2022.116804
44398381 74380 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL190286 74380 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor
ChEMBL 599 11 6 8 -0.2 CNC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CS[C@@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N21 10.1021/jm049651m
CHEMBL5286767 201134 0 None - 1 Rat 8.4 pKi = 8.4 Binding
Displacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting methodDisplacement of [I125I]AngII form AT2 receptor in rat liver membrane incubated for 1.5 hrs by gamma counting method
ChEMBL 1073 26 13 14 -1.2 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@]1(Cc2ccc(O)cc2)CC(=O)N2[C@H](C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)CS[C@@H]21 10.1016/j.bmcl.2022.128983
10054827 170917 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
CHEMBL42101 170917 0 None - 1 Rat 6.5 pKi = 6.5 Binding
Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.Binding affinity against angiotensin II receptor type 2 (AT2) of rat adrenal medulla.
ChEMBL 634 11 1 8 6.8 CCCCc1nc2ccn(CC(=O)N(c3ccccc3)c3ccccc3)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00037a014
145978684 170340 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4203099 170340 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 445 9 1 6 4.5 CCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145974498 171505 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4217484 171505 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 447 8 1 7 4.3 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168287782 198603 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5198739 198603 0 None 22 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 545 11 1 6 6.8 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10277322 148566 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386172 148566 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11274375 107238 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL290708 107238 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 804 16 1 9 9.4 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
163409135 196962 3 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
CHEMBL5174180 196962 3 None -37 2 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 623 11 1 9 6.5 CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmc.2022.116790
11216369 107147 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289775 107147 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
11994293 89076 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217208 89076 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.9 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
145976532 170385 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4203624 170385 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 443 8 1 6 4.1 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)C2CC2)s1 10.1016/j.bmcl.2017.11.042
168279676 197908 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5188126 197908 0 None 11 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 573 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
166492421 197404 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5181087 197404 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 545 11 1 10 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
10116410 148297 1 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384577 148297 1 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 9 1 7 4.9 CC(C)COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
11445913 140400 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL371395 140400 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 908 19 10 12 0.3 C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
16124929 90220 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
CHEMBL219840 90220 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 2 4 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cn2ccnc2)c1 10.1021/jm0613469
166492441 198284 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5193845 198284 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 504 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162666037 189091 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
CHEMBL4784233 189091 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 14 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CCCC)c1 10.1016/j.bmc.2020.115859
8374 9696 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
9937291 9696 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
CHEMBL34124 9696 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
DB16266 9696 42 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)Binding affinity to type-2 angiotensin-2 receptor (unknown origin)
ChEMBL 507 8 1 4 5.4 COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O 10.1016/j.bmcl.2015.10.084
145964638 171162 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4213069 171162 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 489 11 1 7 5.5 CCCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
168274602 197155 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5177359 197155 0 None 97 2 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 547 11 1 6 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
9806878 134298 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
CHEMBL366210 134298 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 525 10 1 7 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3ccccc32)cc1 10.1021/jm049715t
11995655 148275 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL384462 148275 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 488 10 1 6 5.0 CCCCN(C)C(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
44212339 211815 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL77029 211815 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 438 7 1 6 4.9 CCCCc1nc2ccccc2[n+]([O-])c1Oc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
168297670 199157 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5207511 199157 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 615 10 1 6 7.8 CCCc1ccc(S(=O)(=O)NC(=O)OCCCC(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11181498 107285 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL291124 107285 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 680 14 1 9 6.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
16087341 103656 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL265613 103656 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 1050 25 12 13 0.7 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
16124928 90219 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
CHEMBL219839 90219 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane
ChEMBL 349 7 3 3 2.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1cccc(Cc2cnc[nH]2)c1 10.1021/jm0613469
11180576 107088 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
CHEMBL289306 107088 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 566 11 1 7 6.6 CCCCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1021/jm031031i
145972980 171273 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4214477 171273 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 433 7 1 7 3.9 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
145972801 171381 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4215828 171381 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 474 10 2 6 4.6 CCCCNC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
166492420 199037 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5205556 199037 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 559 11 1 10 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
11722069 77342 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL194864 77342 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 895 22 11 11 0.1 NC(N)=NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
73213175 111477 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
CHEMBL3105391 111477 0 None - 1 Human 4.4 pKi = 4.4 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 397 8 2 6 3.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1 10.1016/j.bmcl.2013.12.040
166492452 197554 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5183386 197554 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 502 11 1 8 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
145966800 170805 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4208670 170805 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 475 9 1 7 5.1 CCC(C)OC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
11366289 174792 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL432095 174792 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 784 18 1 9 9.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(=O)CCCC)cc3c2=O)cc1 10.1021/jm031031i
168283187 197996 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5189691 197996 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 639 11 1 6 8.4 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C34CC5CC(CC(C5)C3)C4)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
10396262 122212 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
CHEMBL3350600 122212 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 1022 27 12 12 0.3 CC[C@H](C)[C@H](NC(=O)c1cc(CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc(Cc2ccc(O)cc2)c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm050280z
16125001 113208 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3105395 113208 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
CHEMBL3139603 113208 0 None - 1 Human 4.3 pKi = 4.3 Binding
Displacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]Sarile from human AT2 receptor expressed in HEK293 cells
ChEMBL 315 7 2 4 2.2 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)O 10.1016/j.bmcl.2013.12.040
11331641 107078 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL289211 107078 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 742 15 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(Cc4ccccc4)C(C)=O)cc3c2=O)cc1 10.1021/jm031031i
67133138 84223 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
CHEMBL2086911 84223 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 12 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2CC)c1 10.1016/j.bmc.2020.115859
10742620 64376 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL1668003 64376 0 None -16 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to angiotensin AT2 receptorBinding affinity to angiotensin AT2 receptor
ChEMBL 460 7 2 6 5.1 CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
163409136 197681 3 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
CHEMBL5185088 197681 3 None -18 2 Human 6.3 pKi = 6.3 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 583 11 1 9 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 10.1016/j.bmc.2022.116790
145965943 170983 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
CHEMBL4210874 170983 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 477 10 1 8 3.9 COCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1 10.1016/j.bmcl.2017.11.042
131590 27475 44 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
CHEMBL130896 27475 44 None -16 3 Human 6.3 pKi = 6.3 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 524 9 3 4 7.2 CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/jm9504722
10276878 87197 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL214592 87197 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 469 11 1 6 5.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
10140383 89165 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217249 89165 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 11 1 7 5.2 CCCCOC(=O)NS(=O)(=O)c1sc(CCCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168271055 196717 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5170220 196717 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 588 11 1 8 7.0 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3nccs3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168272577 197134 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5176951 197134 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 10 1 6 7.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)(C)C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168277414 197242 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5178751 197242 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 517 8 1 10 4.4 COC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2-c2nccs2)cc1 10.1016/j.bmc.2022.116790
166492465 197326 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5179875 197326 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 11 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C(C)C)cc1 10.1016/j.bmc.2022.116790
162650706 186817 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
CHEMBL4747530 186817 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 515 10 1 8 5.0 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C2CC2)c1 10.1016/j.bmc.2020.115859
16087340 172716 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
CHEMBL425077 172716 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometriumDisplacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium
ChEMBL 912 21 10 11 1.2 CC[C@H](C)[C@@H]1Nc2c(Cc3ccc(O)cc3)cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)cc2CN(CC(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O 10.1021/jm051222g
168292360 198656 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5199606 198656 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 581 11 1 6 7.6 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(-c3ccccc3)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
168278021 196972 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
CHEMBL5174301 196972 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 651 10 1 6 8.0 CCCc1ccc(S(=O)(=O)NC(=O)OCCC(F)(F)C(F)(F)F)c(-c2ccc(Cn3c(C(C)(C)C)nc4ccccc43)cc2)c1 10.1016/j.bmc.2022.116804
11994156 88904 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL216688 88904 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 10 1 7 4.8 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
162663560 188717 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779819 188717 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 559 11 1 8 6.2 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
56678310 70025 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
CHEMBL1791259 70025 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometriumBinding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium
ChEMBL 1034 25 11 12 1.0 CC[C@@H](C)[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)N1Cc2cc(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)ccc2[C@@H](Cc2ccc(O)cc2)C1=O 10.1021/jm030921v
10140382 148654 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
CHEMBL386671 148654 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 475 7 1 7 5.1 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)(C)C)s1 10.1021/jm0606185
9891811 126520 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL347703 126520 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
CHEMBL4524047 126520 1 None -8128 2 Rat 5.2 pKi = 5.2 Binding
Receptor binding affinity for Angiotensin II receptor, type 2 determinedReceptor binding affinity for Angiotensin II receptor, type 2 determined
ChEMBL 475 8 2 7 4.8 CCCCc1nc(Cl)c(C(=O)O)n1Cc1cccc2c1ccn2-c1ccccc1-c1nn[nH]n1 10.1016/S0960-894X(01)81137-9
10289461 74542 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
CHEMBL190811 74542 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 526 10 1 8 5.6 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2cnc3cccnc32)cc1 10.1021/jm049715t
162663467 188731 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4779945 188731 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 531 9 1 8 5.4 CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
11316477 74869 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
CHEMBL191468 74869 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptorDisplacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor
ChEMBL 434 9 1 6 4.9 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC#N)cc1 10.1021/jm049715t
163848227 196890 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
CHEMBL5173054 196890 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 518 10 1 8 5.5 CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2C(C)(C)C)cc1 10.1016/j.bmc.2022.116790
145965035 171030 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
CHEMBL4211391 171030 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation countingDisplacement of [125I][Sar1,Ile8]-angiotensin-2 from human recombinant AT2 receptor expressed in HEK293 cell membranes after 240 mins by scintillation counting
ChEMBL 529 10 1 7 5.6 CC(C)Cc1cc(-c2cccc(Cn3ccnc3)c2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 10.1016/j.bmcl.2017.11.042
132404 126564 14 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
CHEMBL348126 126564 14 None -36 2 Human 6.1 pKi = 6.1 Binding
Ki value was evaluated against Angiotensin II receptor, type 2Ki value was evaluated against Angiotensin II receptor, type 2
ChEMBL 637 13 3 5 8.0 CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 10.1021/jm9504722
10161763 87502 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
CHEMBL215159 87502 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 461 8 1 7 4.7 CC(C)Cc1cc(-c2ccc(Cn3ccnc3)cc2)c(S(=O)(=O)NC(=O)OC(C)C)s1 10.1021/jm0606185
10300357 148492 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL385714 148492 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 495 11 1 7 4.3 CCCCS(=O)(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
4189 213701 96 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 213701 96 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 213701 96 None -38 34 Human 5.1 pKi = 5.1 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10182998 148662 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL386718 148662 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 459 10 1 6 4.7 CCCCS(=O)(=O)NC(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
132840 112266 22 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
CHEMBL312104 112266 22 None -3311 3 Rat 4.1 pKi = 4.1 Binding
In vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenalIn vitro binding affinity against angiotensin-2 (AT-2) receptor in rat adrenal
ChEMBL 426 6 2 8 3.5 CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00041a016
11239632 106927 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL287829 106927 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 748 15 1 10 8.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(N(CC)C(=O)c4cccs4)cc3c2=O)cc1 10.1021/jm031031i
118725969 123977 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
CHEMBL3394209 123977 0 None - 1 Human 8.1 pKi = 8.1 Binding
Binding affinity to angiotensin II receptor (unknown origin)Binding affinity to angiotensin II receptor (unknown origin)
ChEMBL 469 10 1 6 5.0 CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1cccc(Cn2ccnc2)c1 10.1021/acs.jmedchem.5b00982
11251114 165965 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
CHEMBL409843 165965 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement.
ChEMBL 714 14 2 9 7.8 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)c4ccccc4)cc3c2=O)cc1 10.1021/jm031031i
73213179 111482 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
CHEMBL3105465 111482 0 None - 1 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 511 10 3 6 3.0 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1c(C)cc(C)cc1C 10.1016/j.bmcl.2013.12.040
10205901 89288 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
CHEMBL217752 89288 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membraneDisplacement of [125I]Ang2 from AT2 receptor in pig uterus membrane
ChEMBL 477 11 1 8 4.1 CCCCOC(=O)NS(=O)(=O)c1sc(CCOC)cc1-c1ccc(Cn2ccnc2)cc1 10.1021/jm0606185
168294859 199055 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5205769 199055 0 None 19 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 561 13 1 6 7.3 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
44400615 163396 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
CHEMBL406907 163396 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometriumDisplacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium
ChEMBL 1007 22 11 13 0.4 CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cccc2c1N[C@@H](Cc1ccc(O)cc1)C(=O)N(CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C2 10.1021/jm0491492
162670036 189435 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
CHEMBL4788892 189435 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysisDisplacement of [125I]Sar-Ile-angiotensin 2 from human AT2 receptor expressed in HEK293 cells incubated for 240 mins by radiometric scintillation analysis
ChEMBL 517 8 1 8 5.0 COC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(C(=O)Cn2ccnc2C(C)(C)C)c1 10.1016/j.bmc.2020.115859
168275495 197250 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
CHEMBL5178838 197250 0 None 66 2 Human 8.0 pKi = 8.0 Binding
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assayDisplacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT2R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
ChEMBL 519 10 1 6 6.2 CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 10.1016/j.bmc.2022.116804
11672486 105287 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
CHEMBL276163 105287 0 None 3 2 Human 8.0 pKi = 8.0 Binding
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree CBinding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 hr at 25 degree C
ChEMBL 994 25 12 12 0.3 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)Nc1cc(Cc2ccc(O)cc2)cc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c1 10.1021/jm050280z
166492458 198353 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
CHEMBL5195051 198353 0 None - 1 Human 8.0 pKi = 8.0 Binding
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting methodDisplacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT2 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
ChEMBL 516 11 1 8 5.3 CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2ccnc2C2CC2)cc1 10.1016/j.bmc.2022.116790
6918 7815 35 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
9804984 7815 35 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
CHEMBL189568 7815 35 None -3 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 10.1016/j.bmcl.2013.12.040
73213180 111483 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
CHEMBL3105466 111483 0 None - 1 Human 5.0 pKi = 5.0 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 499 11 3 7 2.1 CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)NNS(=O)(=O)c1ccc(OC)cc1 10.1016/j.bmcl.2013.12.040
73213252 111484 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
CHEMBL3105467 111484 0 None - 1 Human 5.0 pKi = 5 Binding
Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cellsDisplacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells
ChEMBL 434 11 2 6 2.3 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)c1cccc(Cn2ccnc2)c1)[C@@H](C)CC 10.1016/j.bmcl.2013.12.040
1610 9126 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3941 9126 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
3961 9126 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
590 9126 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
CHEMBL191 9126 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
DB00678 9126 95 None - 4 Human 8.3 pIC50 = 8.3 Binding
In vitro binding affinity of compound against angiotensin II AT-2 receptorIn vitro binding affinity of compound against angiotensin II AT-2 receptor
Drug Central 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl None
1037 8359 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
3940 8359 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
5281037 8359 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
588 8359 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
CHEMBL813 8359 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
DB00876 8359 69 None - 1 Rat 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.
Drug Central 424 10 2 5 4.7 CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 None
2583 10548 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
592 10548 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
65999 10548 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
CHEMBL1017 10548 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
DB00966 10548 118 None - 1 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma countingDisplacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
Drug Central 514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 None
16133225 7207 52 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
172198 7207 52 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
2504 7207 52 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
45266664 7207 52 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
5272 7207 52 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
CHEMBL408403 7207 52 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
DB11842 7207 52 None 1 5 Human 8.0 pKd = 8.0 Binding
NoneNone
Drug Central None None None None None
16133225 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
16133225 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
172198 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
172198 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
2504 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
2504 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
45266664 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
45266664 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
5272 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5272 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
CHEMBL408403 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL408403 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
DB11842 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
DB11842 7207 52 None 1 5 Human 10.2 pKd = 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7850406
44299731 7208 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
44299731 7208 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
585 7208 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
585 7208 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
CHEMBL56448 7208 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL56448 7208 0 None - 1 Human 10.4 pKd = 10.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8242249
123794 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
123794 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
3944 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
3944 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
594 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
594 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
CHEMBL1885579 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1764088
CHEMBL1885579 7680 46 None 67608 2 Human 10.6 pKd = 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2775266
5311345 9795 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
5311345 9795 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
597 9795 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
597 9795 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
CHEMBL321820 9795 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 1709220
CHEMBL321820 9795 46 None 10 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 508 7 1 5 4.5 OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C 2402226
595 9770 0 None - 1 Rat 9.3 pKd = 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2194459
4189 213701 96 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL1559 213701 96 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
CHEMBL91 213701 96 None -38 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A)
Drug Central 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 None
36736 10247 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
598 10247 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6324663 10247 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
CHEMBL356431 10247 0 None -5 3 Human 8.0 pKi = 8.0 Binding
Displacement of radiolabeled saralasin from human AT2 receptorDisplacement of radiolabeled saralasin from human AT2 receptor
Drug Central None None None None None
6893 9642 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
9987879 9642 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18207609
6894 7206 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
91691124 7206 0 None -1 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 21464395
6918 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
9804984 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
CHEMBL189568 7815 35 None -3 3 Human 9.4 pKi = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 475 10 1 7 5.1 CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C 15537354
11931 7851 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
126456406 7851 0 None 10 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 621 10 1 8 6.7 CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
11930 7806 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
15780052 7806 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944
CHEMBL289472 7806 0 None 537 2 Human 9.5 pKi = 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 623 9 1 8 6.8 CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 28379944