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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

A-71623	207	None	26	Human	Binding	IC50	=	1900.00	5.72	-	3	Inhibitory activity against cholecystokinin type A receptor from bovine striatal binding assay	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm00100a033
A-71623	207	None	26	Rat	Binding	Ki	=	0.30	9.52	831	3	Inhibition of [125I]BH-CCK-8 binding to Cholecystokinin type A receptor of rat pancreatic tissue	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm990252e
A-71623	207	None	26	Rat	Binding	IC50	=	0.05	10.30	831	3	Inhibitory activity against cholecystokinin type A receptor from rat pancreas binding assay	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm00100a033
AFATINIB	11001	None	62	Human	Binding	AC50	=	10999.90	4.96	-	4	Binding affinity towards human CCKAR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	485.2	8	2	7	4.39	CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1	https://dx.doi.org/10.1038/s41467-023-40064-9
ALPRAZOLAM	205943	None	20	Rat	Binding	IC50	=	64000.00	4.19	-	6	Displacement of [125I]CCK from Cholecystokinin receptor of rat pancreas	ChEMBL	308.1	1	0	4	3.58	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	https://dx.doi.org/10.1021/jm00396a028
ALPRAZOLAM	205943	None	20	Rat	Binding	pIC50	=	4.19	8.38	-	6	Displacement of [125I]CCK from Cholecystokinin receptor of rat pancreas	Drug Central	308.1	1	0	4	3.58	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2	-
AMIGLUMIDE	9901	None	8	Guinea pig	Binding	IC50	=	4200.00	5.38	-	1	Compound was evaluated for the binding affinity against Cholecystokinin type A receptor in cortical cells.	ChEMBL	440.3	14	2	3	5.01	CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1	https://dx.doi.org/10.1021/jm00124a003
AMIGLUMIDE	9901	None	8	Guinea pig	Binding	IC50	=	12.00	7.92	-	1	Compound was evaluated for the binding affinity against Cholecystokinin type A receptor in pancreatic acinar cell	ChEMBL	440.3	14	2	3	5.01	CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1	https://dx.doi.org/10.1021/jm00124a003
AMIGLUMIDE	9901	None	8	Guinea pig	Binding	IC50	=	12.00	7.92	-	1	Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type A receptor in guinea pig pancreatic membranes.	ChEMBL	440.3	14	2	3	5.01	CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc2ccccc2c1	https://dx.doi.org/10.1021/jm00116a002
AMSACRINE	167616	None	49	Human	Binding	AC50	=	21999.90	4.66	-	15	Binding affinity towards human CCKAR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	393.1	5	2	5	4.51	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	https://dx.doi.org/10.1038/s41467-023-40064-9
ARL-15849	472	None	0	Rat	Binding	pKi	None	-	10.50	7943	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9476993
ASPERLICIN	99522	None	8	Human	Binding	IC50	=	1400.00	5.85	-	1	Inhibition of cholecystokinin A receptor	ChEMBL	535.2	4	3	7	3.14	CC(C)C[C@@H]1N[C@H]2N(C1=O)c1ccccc1[C@@]2(O)C[C@@H]1NC(=O)c2ccccc2-n2c1nc1ccccc1c2=O	https://dx.doi.org/10.1021/np9800102
ATAZANAVIR	10423	None	49	Human	Binding	AC50	=	17599.90	4.75	-	4	Binding affinity towards human CCKAR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	704.4	14	5	9	4.21	COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C	https://dx.doi.org/10.1038/s41467-023-40064-9
BEPRIDIL	4301	None	35	Human	Binding	AC50	=	23230.00	4.63	-	22	Binding affinity towards human CCKAR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	366.3	10	0	3	4.83	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	https://dx.doi.org/10.1038/s41467-023-40064-9
CANDESARTAN CILEXETIL	4402	None	68	Human	Binding	AC50	=	21999.90	4.66	-	29	Binding affinity towards human CCKAR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	610.3	10	1	11	6.32	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	https://dx.doi.org/10.1038/s41467-023-40064-9
cannabidiol	788	None	26	Human	Binding	AC50	=	18330.30	4.74	-	23	Binding affinity towards human CCKAR in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	314.2	6	2	2	5.85	C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O	https://dx.doi.org/10.1038/s41467-023-40064-9
CCK-33	815	None	0	Rat	Binding	pKd	=	-	9.30	3	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/6256771
CCK-8	822	None	42	Human	Binding	IC50	=	1.32	8.88	-2	6	In vitro for binding affinity against human cholecystokinin type A receptor.	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm970265x
CCK-8	822	None	42	Human	Binding	pKi	=	9.55	8.02	-2	6	Displacement of radiolabeled CCK-8s from human CCK1 receptor	Drug Central	-	-	-	-	-	-	-
CCK-8	822	None	42	Human	Binding	IC50	=	0.63	9.20	-2	6	Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type A receptor	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm9601664

Showing 1 to 20 of 2,759 entries

	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

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Ligand source activities (1 row/activity)