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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

1-(benzo[d]thiazol-2-yl)-N-(3-ethoxy-4-methoxyphenyl)piperidin-4-amine	220110	UNDEFINED	0	Human	Binding	pKi	=	10000.00	5.00	-1	3	-	PDSP KiDatabase	383.2	6	1	6	4.78	CCOc1cc(NC2CCN(c3nc4ccccc4s3)CC2)ccc1OC	-
1-(benzo[d]thiazol-2-ylmethyl)-N-(3-ethoxy-4-methoxyphenyl)piperidin-4-amine	220111	UNDEFINED	0	Human	Binding	pKi	=	10000.00	5.00	-1	3	-	PDSP KiDatabase	397.2	7	1	6	4.78	CCOc1cc(NC2CCN(Cc3nc4ccccc4s3)CC2)ccc1OC	-
2-(4-((4-(benzo[d]oxazol-2-ylamino)piperidin-1-yl)methyl)-2-ethoxy-5-fluorophenoxy)ethanol	220122	UNDEFINED	0	Human	Binding	pKi	=	10000.00	5.00	-1	3	-	PDSP KiDatabase	429.2	9	2	7	3.81	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)c(F)cc1OCCO	-
[D-Tyr⁸]CYN 154806	1506	None	0	Human	Binding	pKi	=	-	6.45	-112	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10818261
[L-Tyr⁸]CYN 154806	2375	None	0	Human	Binding	pKi	=	-	6.50	-56	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10818261
ACQ090	266	None	0	Human	Binding	pKi	=	-	7.90	-	1	Unclassified	Guide to Pharmacology	526.3	7	0	5	4.63	COc1ccc(CC(C)CN2C[C@@H](C(=O)N3CCN(c4ccc(F)c(F)c4)CC3)[C@H]3CCCC[C@H]3C2)cn1	-
astemizole	505	UNDEFINED	55	Human	Binding	pKi	=	10000.00	5.00	-5754	48	-	PDSP KiDatabase	458.2	8	1	5	5.35	COc1ccc(CCN2CCC(Nc3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	-
BIM 23023	637	None	0	Human	Binding	pKi	=	-	8.10	-19	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/7988476
BIM 23023	637	None	0	Rat	Binding	pKi	=	-	7.00	-251	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9600011
BIM 23030	639	None	0	Human	Binding	pKi	=	-	7.50	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9650799
BIM 23030	639	None	0	Human	Binding	pKi	=	-	7.50	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10598788
BIM 23034	640	None	0	Human	Binding	pKi	=	-	8.10	-3	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/7988476
BIM 23050	641	None	0	Human	Binding	pKi	=	-	7.80	-10	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/7988476
BIM 23052	642	None	0	Human	Binding	pKi	=	-	9.05	2	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8769372
BIM 23052	642	None	0	Human	Binding	pKi	=	-	9.05	2	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9650799
BIM 23052	642	None	0	Human	Binding	pKi	=	-	9.05	2	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10598788
BIM 23052	642	None	0	Rat	Binding	pKi	=	-	8.50	-3	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9600011
BIM 23056	643	None	0	Human	Binding	pKi	=	-	7.05	-4	7	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9650799
BIM 23056	643	None	0	Human	Binding	pKi	=	-	7.05	-4	7	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/10598788
BIM 23058	644	None	0	Human	Binding	pKi	=	-	8.80	-	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/7988476

Showing 1 to 20 of 1,068 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

BIM 23023	637	None	0	Mouse	Functional	pIC50	=	-	7.90	-	8	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23034	640	None	0	Mouse	Functional	pIC50	=	-	7.20	-31622	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23050	641	None	0	Mouse	Functional	pIC50	=	-	8.30	79	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23052	642	None	0	Mouse	Functional	pIC50	=	-	9.40	19	9	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23056	643	None	0	Mouse	Functional	pIC50	=	-	10.70	15848	7	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23056	643	None	0	Rat	Functional	pIC50	=	-	6.50	-15848	7	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9166718
BIM 23058	644	None	0	Mouse	Functional	pIC50	=	-	10.40	-	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23059	645	None	0	Mouse	Functional	pIC50	=	-	8.20	-794	4	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23066	647	None	0	Mouse	Functional	pIC50	=	-	9.00	3	2	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23068	648	None	0	Mouse	Functional	pIC50	=	-	9.10	-5	6	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/8100350
BIM 23197	650	None	0	Human	Functional	pIC50	=	-	7.60	-125	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9045884
BIM 23454	654	None	0	Human	Functional	pIC50	=	-	7.30	-1	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11897676
BIM 23627	655	None	0	Human	Functional	pIC50	=	-	7.40	-6	5	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/11897676
BN-81,644	697	None	5	Human	Functional	IC50	=	2.70	8.57	-	4	Inhibitory concentration required to inhibit SRIF-14 induced reduction of cAMP in CHO-K1 cells expressing the human sst3 receptor.	ChEMBL	426.3	8	3	2	7.02	CCCCC1(CCCC)N[C@@H](c2ncc(-c3ccccc3)[nH]2)Cc2c1[nH]c1ccccc21	https://dx.doi.org/10.1021/jm0108449
BOC-ATE	700	None	0	Human	Functional	pIC50	=	-	7.50	-39	3	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/15709181
CHEMBL102892	4627	None	0	Human	Functional	IC50	=	19.00	7.72	-	2	Inhibitory concentration required to inhibit SRIF-14 induced reduction of cAMP in CHO-K1 cells expressing the human sst3 receptor.	ChEMBL	396.2	3	3	2	6.07	c1ccc(-c2c[nH]c(C3Cc4c([nH]c5ccccc45)C(C4CCCCC4)N3)n2)cc1	https://dx.doi.org/10.1021/jm0108449
CHEMBL1237140	16536	None	0	Human	Functional	IC50	=	2.70	8.57	-	3	Antagonist activity at human SST3 expressed in CHO-K1 cells assessed as inhibition of SRIF-14-induced foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay	ChEMBL	426.3	8	3	2	7.02	CCCCC1(CCCC)N[C@H](c2nc(-c3ccccc3)c[nH]2)Cc2c1[nH]c1ccccc21	https://dx.doi.org/10.1021/ml500079u
CHEMBL1237140	16536	None	0	Human	Functional	IC50	=	6.80	8.17	-	3	Inhibitory concentration required to inhibit SRIF-14 induced reduction of cAMP in CHO-K1 cells expressing the human sst3 receptor.	ChEMBL	426.3	8	3	2	7.02	CCCCC1(CCCC)N[C@H](c2nc(-c3ccccc3)c[nH]2)Cc2c1[nH]c1ccccc21	https://dx.doi.org/10.1021/jm0108449
CHEMBL173778	60087	None	0	Human	Functional	IC50	=	450.00	6.35	-	1	Inhibitory concentration required to inhibit SRIF-14 induced reduction of cAMP in CHO-K1 cells expressing the human sst3 receptor.	ChEMBL	468.3	10	3	2	8.11	CCCCCC1(CCCCC)NC(c2nc(-c3ccccc3)c[nH]2)Cc2c1[nH]c1ccc(C)cc21	https://dx.doi.org/10.1021/jm0108449
CHEMBL1823873	211491	None	10	Human	Functional	EC50	=	0.63	9.20	-1	5	Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay	ChEMBL	-	-	-	-	-	C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O	https://dx.doi.org/10.1021/jm200307v

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Ligand source activities (1 row/activity)