Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| CHEMBL1824052 | 211495 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | 3 | 5 | Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm200307v | ||||
| CHEMBL1824051 | 211494 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | 3 | 5 | Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm200307v | ||||
| 90644981 | 111876 | None | 0 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | 6 | 2 | Agonist activity at mouse SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at mouse SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 365 | 5 | 3 | 2 | 4.1 | O=C(N[C@@H]1CCCC[C@@H]1NCc1c[nH]c2ccccc12)c1ccc(F)cc1 | 10.1021/ml500079u | ||
| CHEMBL3287613 | 111876 | None | 0 | Mouse | Functional | pEC50 | = | 9.3 | 9.3 | 6 | 2 | Agonist activity at mouse SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at mouse SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 365 | 5 | 3 | 2 | 4.1 | O=C(N[C@@H]1CCCC[C@@H]1NCc1c[nH]c2ccccc12)c1ccc(F)cc1 | 10.1021/ml500079u | ||
| 127030549 | 138609 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 476 | 4 | 3 | 7 | 4.2 | Cc1nc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccccc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1016/j.bmcl.2016.02.022 | ||
| CHEMBL3775042 | 138609 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 476 | 4 | 3 | 7 | 4.2 | Cc1nc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccccc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1016/j.bmcl.2016.02.022 | ||
| 90644992 | 111889 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 426 | 5 | 2 | 2 | 6.0 | O=C(N[C@@H]1CCCC[C@@H]1NCc1ccc(Cl)c(Cl)c1)c1ccc2ccccc2c1 | 10.1021/ml500079u | ||
| CHEMBL3287628 | 111889 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 426 | 5 | 2 | 2 | 6.0 | O=C(N[C@@H]1CCCC[C@@H]1NCc1ccc(Cl)c(Cl)c1)c1ccc2ccccc2c1 | 10.1021/ml500079u | ||
| CHEMBL1824056 | 211499 | None | 0 | Human | Functional | pEC50 | = | 9.3 | 9.3 | 3 | 5 | Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm200307v | ||||
| CHEMBL1823873 | 211491 | None | 10 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -1 | 5 | Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm200307v | ||||
| 16129706 | 211490 | None | 36 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -16 | 12 | Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm200307v | ||||
| CHEMBL1823872 | 211490 | None | 36 | Human | Functional | pEC50 | = | 9.1 | 9.1 | -16 | 12 | Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm200307v | ||||
| CHEMBL1824050 | 211493 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 3 | 5 | Agonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human sst3 receptor expressed in CCL39 cells after 5 hrs by luciferase reporter gene assay |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm200307v | ||||
| 10114 | 2556 | None | 25 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -1 | 6 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1016/j.bmcl.2016.02.022 | ||
| 56927659 | 2556 | None | 25 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -1 | 6 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1016/j.bmcl.2016.02.022 | ||
| CHEMBL2204935 | 2556 | None | 25 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -1 | 6 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1016/j.bmcl.2016.02.022 | ||
| 90644993 | 111890 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 444 | 5 | 2 | 2 | 6.1 | O=C(N[C@@H]1CCCC[C@@H]1NCc1ccc(Cl)c(Cl)c1)c1ccc2cc(F)ccc2c1 | 10.1021/ml500079u | ||
| CHEMBL3287629 | 111890 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 444 | 5 | 2 | 2 | 6.1 | O=C(N[C@@H]1CCCC[C@@H]1NCc1ccc(Cl)c(Cl)c1)c1ccc2cc(F)ccc2c1 | 10.1021/ml500079u | ||
| 139392666 | 190311 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -41 | 5 | Agonist activity at human SST3Agonist activity at human SST3 |
ChEMBL | 430 | 3 | 2 | 5 | 4.3 | Cc1ccc(F)c2[nH]c(-c3cncc(-c4cc(F)cc(C#N)c4)c3N3CC[C@H](N)C3)nc12 | 10.1016/j.bmcl.2022.128807 | ||
| CHEMBL5174433 | 190311 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -41 | 5 | Agonist activity at human SST3Agonist activity at human SST3 |
ChEMBL | 430 | 3 | 2 | 5 | 4.3 | Cc1ccc(F)c2[nH]c(-c3cncc(-c4cc(F)cc(C#N)c4)c3N3CC[C@H](N)C3)nc12 | 10.1016/j.bmcl.2022.128807 | ||
| 127032341 | 138713 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 378 | 2 | 3 | 3 | 4.5 | CC(C)(C)c1c[nH]c(C2Cc3c([nH]c4ccccc34)C(C3CCOCC3)N2)n1 | 10.1016/j.bmcl.2016.02.022 | ||
| CHEMBL3775825 | 138713 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 378 | 2 | 3 | 3 | 4.5 | CC(C)(C)c1c[nH]c(C2Cc3c([nH]c4ccccc34)C(C3CCOCC3)N2)n1 | 10.1016/j.bmcl.2016.02.022 | ||
| 122186639 | 122947 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 345 | 6 | 2 | 2 | 5.0 | Cc1ccc(-c2c[nH]c(C3(NCCc4ccccc4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| CHEMBL3605797 | 122947 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 345 | 6 | 2 | 2 | 5.0 | Cc1ccc(-c2c[nH]c(C3(NCCc4ccccc4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| 90644990 | 111885 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 320 | 5 | 2 | 2 | 3.9 | CC(C)(C)CCN[C@H]1CCCC[C@H]1NC(=O)c1ccc(F)cc1 | 10.1021/ml500079u | ||
| CHEMBL3287622 | 111885 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 320 | 5 | 2 | 2 | 3.9 | CC(C)(C)CCN[C@H]1CCCC[C@H]1NC(=O)c1ccc(F)cc1 | 10.1021/ml500079u | ||
| 122186627 | 122935 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 370 | 5 | 3 | 2 | 5.4 | Cc1ccc(-c2c[nH]c(C3(NCc4c[nH]c5ccccc45)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| CHEMBL3605785 | 122935 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 370 | 5 | 3 | 2 | 5.4 | Cc1ccc(-c2c[nH]c(C3(NCc4c[nH]c5ccccc45)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| 127032662 | 138642 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 454 | 3 | 3 | 4 | 6.1 | c1ccc2c3c([nH]c2c1)[C@@H](C1CCOCC1)N[C@@H](c1nc(-c2csc4ccccc24)c[nH]1)C3 | 10.1016/j.bmcl.2016.02.022 | ||
| CHEMBL3775284 | 138642 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 454 | 3 | 3 | 4 | 6.1 | c1ccc2c3c([nH]c2c1)[C@@H](C1CCOCC1)N[C@@H](c1nc(-c2csc4ccccc24)c[nH]1)C3 | 10.1016/j.bmcl.2016.02.022 | ||
| 122186634 | 122942 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 384 | 6 | 3 | 2 | 5.5 | Cc1ccc(-c2c[nH]c(C3(NCCc4c[nH]c5ccccc45)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| CHEMBL3605792 | 122942 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 384 | 6 | 3 | 2 | 5.5 | Cc1ccc(-c2c[nH]c(C3(NCCc4c[nH]c5ccccc45)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| 127031456 | 138570 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 412 | 3 | 3 | 3 | 5.2 | Cc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1 | 10.1016/j.bmcl.2016.02.022 | ||
| CHEMBL3774791 | 138570 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 412 | 3 | 3 | 3 | 5.2 | Cc1ccc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)cc1 | 10.1016/j.bmcl.2016.02.022 | ||
| 122186655 | 122963 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 339 | 5 | 2 | 3 | 4.2 | Cc1ccc(-c2c[nH]c(C3(NCC4CCOCC4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| CHEMBL3605813 | 122963 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 339 | 5 | 2 | 3 | 4.2 | Cc1ccc(-c2c[nH]c(C3(NCC4CCOCC4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| 90644983 | 111878 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 340 | 5 | 2 | 2 | 4.0 | Cc1ccc(CN[C@H]2CCCC[C@H]2NC(=O)c2ccc(F)cc2)cc1 | 10.1021/ml500079u | ||
| CHEMBL3287615 | 111878 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 340 | 5 | 2 | 2 | 4.0 | Cc1ccc(CN[C@H]2CCCC[C@H]2NC(=O)c2ccc(F)cc2)cc1 | 10.1021/ml500079u | ||
| 90644985 | 111880 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 356 | 6 | 2 | 3 | 3.7 | COc1ccc(CN[C@H]2CCCC[C@H]2NC(=O)c2ccc(F)cc2)cc1 | 10.1021/ml500079u | ||
| CHEMBL3287617 | 111880 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 356 | 6 | 2 | 3 | 3.7 | COc1ccc(CN[C@H]2CCCC[C@H]2NC(=O)c2ccc(F)cc2)cc1 | 10.1021/ml500079u | ||
| 90644998 | 111902 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 379 | 5 | 2 | 2 | 4.5 | CN(Cc1c[nH]c2ccccc12)[C@H]1CCCC[C@H]1NC(=O)c1ccc(F)cc1 | 10.1021/ml500079u | ||
| CHEMBL3287643 | 111902 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 379 | 5 | 2 | 2 | 4.5 | CN(Cc1c[nH]c2ccccc12)[C@H]1CCCC[C@H]1NC(=O)c1ccc(F)cc1 | 10.1021/ml500079u | ||
| 90644997 | 111897 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 369 | 5 | 3 | 2 | 3.9 | O=C(N[C@@H]1CCC[C@H]1NCc1c[nH]c2ccccc12)c1ccc(F)c(F)c1 | 10.1021/ml500079u | ||
| CHEMBL3287635 | 111897 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Agonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assayAgonist activity at human SST3 expressed in CHO-K1 cells assessed as foreskin-stimulated cAMP accumulation after 45 mins by TR-FRET assay |
ChEMBL | 369 | 5 | 3 | 2 | 3.9 | O=C(N[C@@H]1CCC[C@H]1NCc1c[nH]c2ccccc12)c1ccc(F)c(F)c1 | 10.1021/ml500079u | ||
| 127032661 | 138612 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 418 | 3 | 3 | 4 | 5.3 | Cc1csc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)c1 | 10.1016/j.bmcl.2016.02.022 | ||
| CHEMBL3775055 | 138612 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsAntagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levels |
ChEMBL | 418 | 3 | 3 | 4 | 5.3 | Cc1csc(-c2c[nH]c([C@H]3Cc4c([nH]c5ccccc45)[C@@H](C4CCOCC4)N3)n2)c1 | 10.1016/j.bmcl.2016.02.022 | ||
| 122186653 | 122961 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 382 | 5 | 2 | 3 | 5.5 | Cc1ccc(-c2c[nH]c(C3(NCc4ccc5ncccc5c4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| CHEMBL3605811 | 122961 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 382 | 5 | 2 | 3 | 5.5 | Cc1ccc(-c2c[nH]c(C3(NCc4ccc5ncccc5c4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| 122186637 | 122945 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 370 | 5 | 3 | 2 | 5.4 | Cc1ccc(-c2c[nH]c(C3(NCc4cc5ccccc5[nH]4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
| CHEMBL3605795 | 122945 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | Agonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assayAgonist activity at human SSTR3 expressed in CHO cells assessed as intracellular cAMP level after 45 mins by time-resolved fluorescence assay |
ChEMBL | 370 | 5 | 3 | 2 | 5.4 | Cc1ccc(-c2c[nH]c(C3(NCc4cc5ccccc5[nH]4)CCCC3)n2)cc1 | 10.1016/j.bmcl.2015.06.087 | ||
Showing 1 to 50 of 528 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 162648021 | 180079 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 520 | 5 | 2 | 5 | 5.9 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| CHEMBL4746816 | 180079 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 520 | 5 | 2 | 5 | 5.9 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cccc(F)c4O)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| 140762500 | 181839 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 529 | 5 | 1 | 5 | 6.1 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(F)cc(C#N)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| CHEMBL4777122 | 181839 | None | 0 | Human | Binding | pEC50 | = | 8.4 | 8.4 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 529 | 5 | 1 | 5 | 6.1 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(F)cc(C#N)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| 140836905 | 194015 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human SST3 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST3 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay |
ChEMBL | 474 | 3 | 2 | 5 | 5.5 | N#Cc1cc(F)cc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O | 10.1021/acsmedchemlett.2c00431 | ||
| CHEMBL5276605 | 194015 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human SST3 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assayAgonist activity at human SST3 receptor expressed in CHO-K1 cells assessed as inhibition of NKH477-induced intracellular cAMP accumulation incubated for 20 mins by HTRF assay |
ChEMBL | 474 | 3 | 2 | 5 | 5.5 | N#Cc1cc(F)cc(-c2ccc3ncc(-c4cc(F)cc(F)c4)c(N4CCC(N)CC4)c3c2)c1O | 10.1021/acsmedchemlett.2c00431 | ||
| 140762573 | 182483 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 520 | 5 | 2 | 5 | 5.9 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)ccc4F)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| CHEMBL4785112 | 182483 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 520 | 5 | 2 | 5 | 5.9 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)ccc4F)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| 140762567 | 180383 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 520 | 5 | 2 | 5 | 5.9 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| CHEMBL4750691 | 180383 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 520 | 5 | 2 | 5 | 5.9 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(O)cc(F)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| 140762568 | 181370 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 547 | 6 | 2 | 5 | 5.3 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(F)cc(C(N)=O)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| CHEMBL4761949 | 181370 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | Agonist activity at SST3 (unknown origin)Agonist activity at SST3 (unknown origin) |
ChEMBL | 547 | 6 | 2 | 5 | 5.3 | Cc1cc(Cl)cc(N2C=Nc3cc(C)c(-c4cc(F)cc(C(N)=O)c4)cc3C2C(=O)N(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127391 | ||
| 124168080 | 181940 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | Agonist activity at human SST3Agonist activity at human SST3 |
ChEMBL | 507 | 6 | 2 | 7 | 4.4 | Cc1cc(Cl)cc(-c2cnc3ncn(-c4cc(O)cc(F)c4)c(=O)c3c2CN(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127496 | ||
| CHEMBL4778342 | 181940 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | Agonist activity at human SST3Agonist activity at human SST3 |
ChEMBL | 507 | 6 | 2 | 7 | 4.4 | Cc1cc(Cl)cc(-c2cnc3ncn(-c4cc(O)cc(F)c4)c(=O)c3c2CN(C)C[C@@H]2CCCN2)c1 | 10.1016/j.bmcl.2020.127496 | ||
| 16129706 | 211490 | None | 36 | Mouse | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | Tested for inhibition of radioligand binding to cloned somatostatin receptor mSSTR3Tested for inhibition of radioligand binding to cloned somatostatin receptor mSSTR3 |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm960850i | ||||
| CHEMBL1823872 | 211490 | None | 36 | Mouse | Binding | pIC50 | = | 10.1 | 10.1 | - | 5 | Tested for inhibition of radioligand binding to cloned somatostatin receptor mSSTR3Tested for inhibition of radioligand binding to cloned somatostatin receptor mSSTR3 |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm960850i | ||||
| 10114 | 2556 | None | 25 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml300063m | ||
| 56927659 | 2556 | None | 25 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml300063m | ||
| CHEMBL2204935 | 2556 | None | 25 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml300063m | ||
| 16129706 | 211490 | None | 36 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -4 | 5 | Inhibitory concentration against human somatostatin receptor type 3 in CHO-K1 cellsInhibitory concentration against human somatostatin receptor type 3 in CHO-K1 cells |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm050376t | ||||
| CHEMBL1823872 | 211490 | None | 36 | Human | Binding | pIC50 | = | 9.4 | 9.4 | -4 | 5 | Inhibitory concentration against human somatostatin receptor type 3 in CHO-K1 cellsInhibitory concentration against human somatostatin receptor type 3 in CHO-K1 cells |
ChEMBL | None | None | None | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O | 10.1021/jm050376t | ||||
| 118710523 | 113757 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1cccc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)n1 | 10.1021/ml500028c | ||
| CHEMBL3323072 | 113757 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1cccc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)n1 | 10.1021/ml500028c | ||
| 118710525 | 113759 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1ccnc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)c1 | 10.1021/ml500028c | ||
| CHEMBL3323074 | 113759 | None | 0 | Mouse | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | Displacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1ccnc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)c1 | 10.1021/ml500028c | ||
| 71459516 | 83693 | None | 0 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 492 | 4 | 3 | 6 | 4.3 | Cn1cc(C2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 | 10.1021/ml300063m | ||
| CHEMBL2204939 | 83693 | None | 0 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 492 | 4 | 3 | 6 | 4.3 | Cn1cc(C2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 | 10.1021/ml300063m | ||
| 71462983 | 83692 | None | 0 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Cc1nc([C@]2(c3cnn(C)c3)N[C@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1021/ml300063m | ||
| CHEMBL2204938 | 83692 | None | 0 | Mouse | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Cc1nc([C@]2(c3cnn(C)c3)N[C@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1021/ml300063m | ||
| 71461260 | 83694 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 496 | 4 | 3 | 8 | 4.3 | Cc1nc(C2(c3noc(C)n3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1021/ml300063m | ||
| CHEMBL2204940 | 83694 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 496 | 4 | 3 | 8 | 4.3 | Cc1nc(C2(c3noc(C)n3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1021/ml300063m | ||
| 122179477 | 121538 | None | 9 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Binding affinity to rat SSTR3Binding affinity to rat SSTR3 |
ChEMBL | 525 | 5 | 3 | 9 | 3.2 | CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 | 10.1021/ml500514w | ||
| CHEMBL3582336 | 121538 | None | 9 | Rat | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Binding affinity to rat SSTR3Binding affinity to rat SSTR3 |
ChEMBL | 525 | 5 | 3 | 9 | 3.2 | CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 | 10.1021/ml500514w | ||
| 71454093 | 83690 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Cc1nc([C@@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1021/ml300063m | ||
| CHEMBL2204936 | 83690 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Cc1nc([C@@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | 10.1021/ml300063m | ||
| 118710525 | 113759 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-14 from human SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from human SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1ccnc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)c1 | 10.1021/ml500028c | ||
| CHEMBL3323074 | 113759 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-14 from human SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from human SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1ccnc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)c1 | 10.1021/ml500028c | ||
| 10114 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Binding affinity to human somatostatin receptor type 3Binding affinity to human somatostatin receptor type 3 |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1016/j.bmcl.2016.02.022 | ||
| 56927659 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Binding affinity to human somatostatin receptor type 3Binding affinity to human somatostatin receptor type 3 |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1016/j.bmcl.2016.02.022 | ||
| CHEMBL2204935 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Binding affinity to human somatostatin receptor type 3Binding affinity to human somatostatin receptor type 3 |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1016/j.bmcl.2016.02.022 | ||
| 10114 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml300063m | ||
| 56927659 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml300063m | ||
| CHEMBL2204935 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml300063m | ||
| 10114 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-14 from human recombinant SSTR3 expressed in CHO cell membranes incubated for 60 to 90 mins by radioligand binding assayDisplacement of [125I]SS-14 from human recombinant SSTR3 expressed in CHO cell membranes incubated for 60 to 90 mins by radioligand binding assay |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml500514w | ||
| 56927659 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-14 from human recombinant SSTR3 expressed in CHO cell membranes incubated for 60 to 90 mins by radioligand binding assayDisplacement of [125I]SS-14 from human recombinant SSTR3 expressed in CHO cell membranes incubated for 60 to 90 mins by radioligand binding assay |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml500514w | ||
| CHEMBL2204935 | 2556 | None | 25 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-14 from human recombinant SSTR3 expressed in CHO cell membranes incubated for 60 to 90 mins by radioligand binding assayDisplacement of [125I]SS-14 from human recombinant SSTR3 expressed in CHO cell membranes incubated for 60 to 90 mins by radioligand binding assay |
ChEMBL | 494 | 4 | 3 | 7 | 4.3 | Fc1ccc(cc1)c1cnc([nH]1)[C@H]1Cc2c3ccccc3[nH]c2[C@@](N1)(c1noc(n1)C)c1cnn(c1)C | 10.1021/ml500514w | ||
| 118710524 | 113758 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1cccc([C@@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)n1 | 10.1021/ml500028c | ||
| CHEMBL3323073 | 113758 | None | 0 | Mouse | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | Displacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzerDisplacement of [125I]SS-14 from mouse SSTR3 expressed in CHO cells by TopCount analyzer |
ChEMBL | 561 | 6 | 3 | 7 | 5.2 | CCOC(=O)c1cccc([C@@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)n1 | 10.1021/ml500028c | ||
| 71459516 | 83693 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Displacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 492 | 4 | 3 | 6 | 4.3 | Cn1cc(C2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 | 10.1021/ml300063m | ||
| CHEMBL2204939 | 83693 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | Displacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 minsDisplacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 mins |
ChEMBL | 492 | 4 | 3 | 6 | 4.3 | Cn1cc(C2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 | 10.1021/ml300063m | ||
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