Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
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| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 10197 | 3972 | None | 0 | Human | Functional | pIC50 | ~ | 8 | 8.0 | -14 | 5 | UnclassifiedUnclassified |
Guide to Pharmacology | None | None | None | None | 22753465 | ||||
Showing 1 to 1 of 1 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 2554 | 796 | None | 68 | Mouse | Binding | pKd | = | 4.8 | 4.8 | -81 | 7 | Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay |
ChEMBL | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 10.1021/acs.jmedchem.9b02020 | ||
| 489 | 796 | None | 68 | Mouse | Binding | pKd | = | 4.8 | 4.8 | -81 | 7 | Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay |
ChEMBL | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 10.1021/acs.jmedchem.9b02020 | ||
| 5339 | 796 | None | 68 | Mouse | Binding | pKd | = | 4.8 | 4.8 | -81 | 7 | Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay |
ChEMBL | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 10.1021/acs.jmedchem.9b02020 | ||
| CHEMBL108 | 796 | None | 68 | Mouse | Binding | pKd | = | 4.8 | 4.8 | -81 | 7 | Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay |
ChEMBL | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 10.1021/acs.jmedchem.9b02020 | ||
| DB00564 | 796 | None | 68 | Mouse | Binding | pKd | = | 4.8 | 4.8 | -81 | 7 | Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay |
ChEMBL | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 10.1021/acs.jmedchem.9b02020 | ||
| 2554 | 796 | None | 68 | Human | Binding | pKd | = | 8.3 | 8.3 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 489 | 796 | None | 68 | Human | Binding | pKd | = | 8.3 | 8.3 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 5339 | 796 | None | 68 | Human | Binding | pKd | = | 8.3 | 8.3 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| CHEMBL108 | 796 | None | 68 | Human | Binding | pKd | = | 8.3 | 8.3 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| DB00564 | 796 | None | 68 | Human | Binding | pKd | = | 8.3 | 8.3 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Drug Central | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | None | ||
| 2554 | 796 | None | 68 | Human | Binding | pKd | = | 4.8 | 4.8 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Guide to Pharmacology | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 32049522 | ||
| 489 | 796 | None | 68 | Human | Binding | pKd | = | 4.8 | 4.8 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Guide to Pharmacology | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 32049522 | ||
| 5339 | 796 | None | 68 | Human | Binding | pKd | = | 4.8 | 4.8 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Guide to Pharmacology | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 32049522 | ||
| CHEMBL108 | 796 | None | 68 | Human | Binding | pKd | = | 4.8 | 4.8 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Guide to Pharmacology | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 32049522 | ||
| DB00564 | 796 | None | 68 | Human | Binding | pKd | = | 4.8 | 4.8 | -1 | 7 | Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis. |
Guide to Pharmacology | 236 | 0 | 1 | 1 | 3.4 | NC(=O)N1c2ccccc2C=Cc2c1cccc2 | 32049522 | ||
Showing 1 to 15 of 15 entries