Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
24861391 188749 None 0 Mouse Functional pEC50 = 9.9 9.9 -2 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 5 1 7 5.3 O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 10.1016/j.bmcl.2008.06.057
CHEMBL505225 188749 None 0 Mouse Functional pEC50 = 9.9 9.9 -2 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 5 1 7 5.3 O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 10.1016/j.bmcl.2008.06.057
CHEMBL505969 188749 None 0 Mouse Functional pEC50 = 9.9 9.9 -2 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 5 1 7 5.3 O=C(O)c1cc(N2CCN(C(=O)c3cn(-c4ccc5c(c4)OCCO5)c(-c4ccc(F)cc4)n3)CC2)cc2ccccc12 10.1016/j.bmcl.2008.06.057
CHEMBL2369765 209680 None 14 Rat Functional pEC50 = 9.8 9.8 - 1
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1806528 208972 None 0 Rat Functional pEC50 = 9.6 9.6 13 2
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
155533399 171843 None 0 Human Functional pEC50 = 9.5 9.5 2 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4468861 171843 None 0 Human Functional pEC50 = 9.5 9.5 2 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
24861060 188725 None 0 Mouse Functional pEC50 = 9.5 9.5 -5 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 7 1 6 6.2 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 10.1016/j.bmcl.2008.06.057
CHEMBL446789 188725 None 0 Mouse Functional pEC50 = 9.5 9.5 -5 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 7 1 6 6.2 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 10.1016/j.bmcl.2008.06.057
CHEMBL504861 188725 None 0 Mouse Functional pEC50 = 9.5 9.5 -5 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 578 7 1 6 6.2 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2F)c1 10.1016/j.bmcl.2008.06.057
155564367 175154 None 0 Human Functional pEC50 = 9.5 9.5 457 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4570130 175154 None 0 Human Functional pEC50 = 9.5 9.5 457 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155543846 173210 None 0 Human Functional pEC50 = 9.5 9.5 14 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4522865 173210 None 0 Human Functional pEC50 = 9.5 9.5 14 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
56663263 64016 None 0 Rat Functional pEC50 = 9.5 9.5 7 2
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1807150 64016 None 0 Rat Functional pEC50 = 9.5 9.5 7 2
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
155553502 174173 None 0 Human Functional pEC50 = 9.5 9.5 26 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4547294 174173 None 0 Human Functional pEC50 = 9.5 9.5 26 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155540415 172937 None 0 Human Functional pEC50 = 9.4 9.4 1584 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516868 172937 None 0 Human Functional pEC50 = 9.4 9.4 1584 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155557285 174516 None 0 Human Functional pEC50 = 9.4 9.4 295 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4555341 174516 None 0 Human Functional pEC50 = 9.4 9.4 295 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
5311400 3291 None 1 Rat Functional pEC50 = 9.4 9.4 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
900 3291 None 1 Rat Functional pEC50 = 9.4 9.4 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL262197 3291 None 1 Rat Functional pEC50 = 9.4 9.4 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
155559320 174862 None 0 Human Functional pEC50 = 9.4 9.4 -1 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4563364 174862 None 0 Human Functional pEC50 = 9.4 9.4 -1 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL1806532 208975 None 0 Rat Functional pEC50 = 9.4 9.4 5 2
Agonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assayAgonist activity at gastrin receptor in rat AR4-2J cells assessed as intracellular calcium mobilization by fluorescence assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
155526914 171200 None 0 Human Functional pEC50 = 9.4 9.4 -2 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4459331 171200 None 0 Human Functional pEC50 = 9.4 9.4 -2 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155546692 173640 None 0 Human Functional pEC50 = 9.4 9.4 3 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4534236 173640 None 0 Human Functional pEC50 = 9.4 9.4 3 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
9853654 22787 None 41 Rat Functional pEC50 = 9.4 9.4 -1 4
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL1328 22787 None 41 Rat Functional pEC50 = 9.4 9.4 -1 4
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
155516677 170087 None 0 Human Functional pEC50 = 9.4 9.4 -1 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4443415 170087 None 0 Human Functional pEC50 = 9.4 9.4 -1 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155558199 174767 None 0 Human Functional pEC50 = 9.4 9.4 15488 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4561184 174767 None 0 Human Functional pEC50 = 9.4 9.4 15488 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155524181 170851 None 0 Human Functional pEC50 = 9.4 9.4 -4 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4453982 170851 None 0 Human Functional pEC50 = 9.4 9.4 -4 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
101823779 1395 None 35 Human Functional pEC50 = 9.3 9.3 354 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
16162108 1395 None 35 Human Functional pEC50 = 9.3 9.3 354 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
8408 1395 None 35 Human Functional pEC50 = 9.3 9.3 354 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL4451154 1395 None 35 Human Functional pEC50 = 9.3 9.3 354 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
155555346 174370 None 0 Human Functional pEC50 = 9.3 9.3 -3 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4551834 174370 None 0 Human Functional pEC50 = 9.3 9.3 -3 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
4627 821 None 50 Human Functional pEC50 = 9.3 9.3 -1 6
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
864 821 None 50 Human Functional pEC50 = 9.3 9.3 -1 6
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
9833444 821 None 50 Human Functional pEC50 = 9.3 9.3 -1 6
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL1121 821 None 50 Human Functional pEC50 = 9.3 9.3 -1 6
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
DB09142 821 None 50 Human Functional pEC50 = 9.3 9.3 -1 6
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
155544674 174934 None 0 Human Functional pEC50 = 9.3 9.3 -1 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4565336 174934 None 0 Human Functional pEC50 = 9.3 9.3 -1 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10509035 14507 None 0 Rat Functional pEC50 = 9.3 9.3 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
CHEMBL120150 14507 None 0 Rat Functional pEC50 = 9.3 9.3 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
4627 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
864 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
9833444 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL1121 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
DB09142 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None None 10.1021/jm0000416
4627 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
864 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
9833444 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
CHEMBL1121 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
DB09142 821 None 50 Rat Functional pEC50 = 9.2 9.2 -6 6
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
155532425 171746 None 0 Human Functional pEC50 = 9.2 9.2 -3 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
CHEMBL4467338 171746 None 0 Human Functional pEC50 = 9.2 9.2 -3 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
16755781 188783 None 12 Mouse Functional pEC50 = 9.1 9.1 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL443189 188783 None 12 Mouse Functional pEC50 = 9.1 9.1 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505409 188783 None 12 Mouse Functional pEC50 = 9.1 9.1 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505727 188783 None 12 Mouse Functional pEC50 = 9.1 9.1 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
155517868 170209 None 0 Human Functional pEC50 = 9.1 9.1 457 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445353 170209 None 0 Human Functional pEC50 = 9.1 9.1 457 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL64605 215854 None 7 Rat Functional pEC50 = 9 9.0 3 4
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
162658676 180980 None 0 Rat Functional pEC50 = 8.9 8.9 3 2
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4758706 180980 None 0 Rat Functional pEC50 = 8.9 8.9 3 2
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
16755781 188783 None 12 Mouse Functional pEC50 = 8.9 8.9 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL443189 188783 None 12 Mouse Functional pEC50 = 8.9 8.9 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505409 188783 None 12 Mouse Functional pEC50 = 8.9 8.9 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL505727 188783 None 12 Mouse Functional pEC50 = 8.9 8.9 -9 3
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 560 7 1 6 6.1 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL120632 208603 None 33 Rat Functional pEC50 = 8.9 8.9 1 3
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
10372489 4261 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 20 7 7 1.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O 10.1021/jm0000416
CHEMBL100538 4261 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 20 7 7 1.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O 10.1021/jm0000416
CHEMBL333477 211390 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm0000416
24861113 188188 None 0 Mouse Functional pEC50 = 8.8 8.8 -24 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 564 7 1 6 5.9 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL498942 188188 None 0 Mouse Functional pEC50 = 8.8 8.8 -24 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 564 7 1 6 5.9 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL506201 188188 None 0 Mouse Functional pEC50 = 8.8 8.8 -24 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 564 7 1 6 5.9 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cc(C(=O)O)c5ccccc5c4)CC3)nc2-c2ccc(F)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL333477 211390 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm9603072
CHEMBL414345 213122 None 7 Human Functional pEC50 = 8.8 8.8 - 1
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0498755
155535579 172048 None 0 Human Functional pEC50 = 8.8 8.8 -158 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471871 172048 None 0 Human Functional pEC50 = 8.8 8.8 -158 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10794634 113100 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
CHEMBL331394 113100 None 0 Rat Functional pEC50 = 8.8 8.8 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
162673242 183206 None 0 Rat Functional pEC50 = 8.8 8.8 2 2
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4795913 183206 None 0 Rat Functional pEC50 = 8.8 8.8 2 2
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
155560670 175090 None 0 Human Functional pEC50 = 8.7 8.7 -72 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4568746 175090 None 0 Human Functional pEC50 = 8.7 8.7 -72 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
162657745 181014 None 0 Rat Functional pEC50 = 8.7 8.7 1 2
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4759105 181014 None 0 Rat Functional pEC50 = 8.7 8.7 1 2
Agonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at rat CCK2R expressed in rat AR42J cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
52949124 875 None 4 Human Functional pEC50 = 6 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Functional pEC50 = 6 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Functional pEC50 = 6 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Functional pEC50 = 6 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
155539345 172831 None 0 Human Functional pEC50 = 7.0 7.0 -3235 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4514283 172831 None 0 Human Functional pEC50 = 7.0 7.0 -3235 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL382051 212291 None 0 Human Functional pEC50 = 7.0 7.0 -109 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL382051 212291 None 0 Human Functional pEC50 = 7.0 7.0 -109 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44580899 189073 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 189073 None 0 Human Functional pEC50 = 6.9 6.9 - 1
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL414592 213143 None 0 Human Functional pEC50 = 7.9 7.9 -8 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)N(C)C(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
162673242 183206 None 0 Human Functional pEC50 = 7.9 7.9 -2 2
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4795913 183206 None 0 Human Functional pEC50 = 7.9 7.9 -2 2
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
162658676 180980 None 0 Human Functional pEC50 = 7.9 7.9 -3 2
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4758706 180980 None 0 Human Functional pEC50 = 7.9 7.9 -3 2
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
155566319 175738 None 0 Human Functional pEC50 = 6.9 6.9 -4677 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4583158 175738 None 0 Human Functional pEC50 = 6.9 6.9 -4677 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL64605 215854 None 7 Human Functional pEC50 = 7.9 7.9 -3 4
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00530
CHEMBL409529 212765 None 2 Human Functional pEC50 = 7.9 7.9 -11 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
155555065 174332 None 0 Human Functional pEC50 = 6.9 6.9 -4168 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4550876 174332 None 0 Human Functional pEC50 = 6.9 6.9 -4168 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
162657745 181014 None 0 Human Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4759105 181014 None 0 Human Functional pEC50 = 7.9 7.9 -1 2
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL266839 210702 None 0 Human Functional pEC50 = 6.9 6.9 -7 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL218763 209397 None 0 Human Functional pEC50 = 7.8 7.8 -2 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
162666759 182318 None 0 Human Functional pEC50 = 6.8 6.8 17 2
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 846 23 9 9 2.9 CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C 10.1021/acs.jmedchem.0c00530
CHEMBL4784305 182318 None 0 Human Functional pEC50 = 6.8 6.8 17 2
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 846 23 9 9 2.9 CC(C)C[C@@H](/C=C/NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)OC(C)(C)C 10.1021/acs.jmedchem.0c00530
155562281 175839 None 0 Human Functional pEC50 = 6.8 6.8 -4168 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4585323 175839 None 0 Human Functional pEC50 = 6.8 6.8 -4168 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
44418923 161783 None 0 Human Functional pEC50 = 7.8 7.8 -5 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL414087 161783 None 0 Human Functional pEC50 = 7.8 7.8 -5 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218763 209397 None 0 Human Functional pEC50 = 7.8 7.8 -2 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
155517761 170221 None 0 Human Functional pEC50 = 7.8 7.8 -416 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445529 170221 None 0 Human Functional pEC50 = 7.8 7.8 -416 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
44346355 157865 None 0 Rat Functional pEC50 = 7.8 7.8 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL408389 157865 None 0 Rat Functional pEC50 = 7.8 7.8 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
155543163 173284 None 0 Human Functional pEC50 = 6.8 6.8 -8709 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4525615 173284 None 0 Human Functional pEC50 = 6.8 6.8 -8709 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL408330 212703 None 0 Human Functional pEC50 = 7.7 7.7 1 4
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL217609 209377 None 0 Human Functional pEC50 = 7.7 7.7 -6 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL408330 212703 None 0 Human Functional pEC50 = 7.7 7.7 1 4
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL208479 209197 None 0 Human Functional pEC50 = 5.7 5.7 -33 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL208479 209197 None 0 Human Functional pEC50 = 5.7 5.7 -33 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10509945 89382 None 0 Human Functional pEC50 = 6.7 6.7 -63 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL2369816 89382 None 0 Human Functional pEC50 = 6.7 6.7 -63 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL407057 212633 None 0 Human Functional pEC50 = 4.7 4.7 -1 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm050921q
10628422 109171 None 0 Rat Functional pEC50 = 8.7 8.7 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
CHEMBL321456 109171 None 0 Rat Functional pEC50 = 8.7 8.7 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
44578767 173514 None 0 Mouse Functional pEC50 = 8.7 8.7 -3 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 517 6 0 6 5.8 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL453083 173514 None 0 Mouse Functional pEC50 = 8.7 8.7 -3 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 517 6 0 6 5.8 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
CHEMBL503822 173514 None 0 Mouse Functional pEC50 = 8.7 8.7 -3 2
Agonist activity against mouse CCK1 receptorAgonist activity against mouse CCK1 receptor
ChEMBL 517 6 0 6 5.8 CCOc1cccc(-n2cc(C(=O)N3CCN(c4cnc5ccccc5c4)CC3)nc2-c2ccc(C)cc2)c1 10.1016/j.bmcl.2008.06.057
1647 1312 None 45 Human Functional pEC50 = 8.6 8.6 2 8
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
5462471 1312 None 45 Human Functional pEC50 = 8.6 8.6 2 8
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
CHEMBL113995 1312 None 45 Human Functional pEC50 = 8.6 8.6 2 8
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
CHEMBL38874 1312 None 45 Human Functional pEC50 = 8.6 8.6 2 8
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL None None None None 10.1021/jm800174p
155568312 176076 None 0 Human Functional pEC50 = 8.6 8.6 -36 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4591101 176076 None 0 Human Functional pEC50 = 8.6 8.6 -36 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL218327 209392 None 0 Human Functional pEC50 = 8.6 8.6 2 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
9853654 22787 None 41 Human Functional pEC50 = 8.6 8.6 -9 4
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL1328 22787 None 41 Human Functional pEC50 = 8.6 8.6 -9 4
Agonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysisAgonist activity at human CCK2R expressed in human A431 cells assessed as intracellular calcium mobilization measured after 24 hrs by Fluo-4AM dye based fluorimetry analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL218327 209392 None 0 Human Functional pEC50 = 8.6 8.6 2 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44396746 127058 None 0 Human Functional pEC50 = 5.6 5.6 -16 2
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 127058 None 0 Human Functional pEC50 = 5.6 5.6 -16 2
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
155540394 172934 None 0 Human Functional pEC50 = 7.6 7.6 -58 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516794 172934 None 0 Human Functional pEC50 = 7.6 7.6 -58 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
4627 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
864 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
9833444 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
CHEMBL1121 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
DB09142 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
CHEMBL269185 210778 None 0 Human Functional pEC50 = 6.6 6.6 -5 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL375360 212216 None 4 Human Functional pEC50 = 7.6 7.6 1 2
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm061268p
4627 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
864 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
9833444 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
CHEMBL1121 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
DB09142 821 None 50 Human Functional pEC50 = 7.6 7.6 -1 6
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None None 10.1021/jm050921q
52949124 875 None 4 Human Functional pEC50 = 6.6 6.6 -2 3
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Functional pEC50 = 6.6 6.6 -2 3
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Functional pEC50 = 6.6 6.6 -2 3
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Functional pEC50 = 6.6 6.6 -2 3
Agonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R V6.51I, Y6.52F mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
10723875 14940 None 0 Rat Functional pEC50 = 8.5 8.5 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
CHEMBL120827 14940 None 0 Rat Functional pEC50 = 8.5 8.5 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
CHEMBL411271 212873 None 0 Rat Functional pEC50 = 8.5 8.5 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL336381 211581 None 0 Human Functional pEC50 = 7.5 7.5 2 4
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
155540739 172505 None 0 Human Functional pEC50 = 6.5 6.5 -3388 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4483457 172505 None 0 Human Functional pEC50 = 6.5 6.5 -3388 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL336381 211581 None 0 Human Functional pEC50 = 7.5 7.5 2 4
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL383458 212311 None 0 Human Functional pEC50 = 6.5 6.5 -1 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL383458 212311 None 0 Human Functional pEC50 = 6.5 6.5 -1 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL205965 209167 None 0 Human Functional pEC50 = 7.4 7.4 42 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL205965 209167 None 0 Human Functional pEC50 = 7.4 7.4 42 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
73347063 89452 None 0 Rat Functional pEC50 = 8.4 8.4 - 1
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371221 89452 None 0 Rat Functional pEC50 = 8.4 8.4 - 1
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL382349 212300 None 0 Human Functional pEC50 = 8.3 8.3 14 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44418924 156880 None 0 Human Functional pEC50 = 8.3 8.3 -8 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 156880 None 0 Human Functional pEC50 = 8.3 8.3 -8 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL382349 212300 None 0 Human Functional pEC50 = 8.3 8.3 14 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
162672110 182858 None 0 Human Functional pEC50 = 7.4 7.4 39 2
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 848 22 9 9 2.0 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00530
CHEMBL4791620 182858 None 0 Human Functional pEC50 = 7.4 7.4 39 2
Agonist activity at CCKBR in human NCI-H345 cells assessed as calcium releaseAgonist activity at CCKBR in human NCI-H345 cells assessed as calcium release
ChEMBL 848 22 9 9 2.0 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00530
155535107 172012 None 0 Human Functional pEC50 = 8.3 8.3 -323 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471525 172012 None 0 Human Functional pEC50 = 8.3 8.3 -323 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155531277 171629 None 0 Human Functional pEC50 = 8.2 8.2 -2 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4465747 171629 None 0 Human Functional pEC50 = 8.2 8.2 -2 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44396745 125036 None 0 Human Functional pEC50 = 6.3 6.3 -4 2
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 125036 None 0 Human Functional pEC50 = 6.3 6.3 -4 2
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL2370248 209812 None 0 Human Functional pEC50 = 7.3 7.3 1 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
44580932 173468 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
CHEMBL452991 173468 None 0 Human Functional pEC50 = 6.2 6.2 - 1
Activity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPRActivity at CCK2R-MOPR coexpressed in CHO cells co-transfected with delta-6-Galphaqi4-myr assessed as intracellular calcium release by FLIPR
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
52949124 875 None 4 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Functional pEC50 = 7.2 7.2 -2 3
Agonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisAgonist activity at human CCK2R H7.39L mutant expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL386682 212385 None 0 Human Functional pEC50 = 8.2 8.2 -60 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN(C)C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
CHEMBL206974 209180 None 0 Human Functional pEC50 = 8.2 8.2 2 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
CHEMBL206974 209180 None 0 Human Functional pEC50 = 8.2 8.2 2 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44387568 62205 None 0 Rat Functional pEC50 = 8.2 8.2 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
CHEMBL177799 62205 None 0 Rat Functional pEC50 = 8.2 8.2 - 1
Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
10327028 89453 None 0 Rat Functional pEC50 = 8.2 8.2 - 1
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371222 89453 None 0 Rat Functional pEC50 = 8.2 8.2 - 1
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10439779 106684 None 0 Rat Functional pEC50 = 8.2 8.2 - 1
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL3143501 106684 None 0 Rat Functional pEC50 = 8.2 8.2 - 1
Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptorEffective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL262172 210526 None 0 Human Functional pEC50 = 8.1 8.1 -19 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL262172 210526 None 0 Human Functional pEC50 = 8.1 8.1 -19 5
Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assayAntagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
155535249 172001 None 0 Human Functional pEC50 = 6.1 6.1 -2754 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1808 68 16 23 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471373 172001 None 0 Human Functional pEC50 = 6.1 6.1 -2754 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1808 68 16 23 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155515427 169947 None 0 Human Functional pEC50 = 7.1 7.1 -1819 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4441596 169947 None 0 Human Functional pEC50 = 7.1 7.1 -1819 2
Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assayAgonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL217236 209370 None 0 Human Functional pEC50 = 8.1 8.1 -4 2
In vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtypeIn vitro smooth muscle contraction activity in guinea pig stomach consisting of CCK/gastrin receptor subtype
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00093a013
52949124 875 None 4 Human Functional pEC50 = 6.0 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Functional pEC50 = 6.0 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Functional pEC50 = 6.0 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Functional pEC50 = 6.0 6.0 -2 3
Partial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysisPartial agonist activity at wild-type human CCK2R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44396655 122048 None 0 Human Functional pEC50 = 7.0 7.0 3 2
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 122048 None 0 Human Functional pEC50 = 7.0 7.0 3 2
Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
45113249 5487 None 0 Human Functional pED50 = 8.5 8.5 - 1
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1259 33 13 12 5.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)CCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
CHEMBL1076229 5487 None 0 Human Functional pED50 = 8.5 8.5 - 1
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1259 33 13 12 5.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)CCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
45113375 5489 None 0 Human Functional pED50 = 8.3 8.3 - 1
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1344 39 13 12 7.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)CCCCCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
CHEMBL1076232 5489 None 0 Human Functional pED50 = 8.3 8.3 - 1
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1344 39 13 12 7.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)CCCCCNC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2009.09.043
46879513 5488 None 0 Human Functional pED50 = 7.1 7.1 - 1
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1118 27 11 10 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.ejmech.2009.09.043
CHEMBL1076230 5488 None 0 Human Functional pED50 = 7.1 7.1 - 1
Agonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formationAgonist activity at human CCK2 receptor expressed in COS7 cells assessed as stimulation of [3H]inositol phosphate formation
ChEMBL 1118 27 11 10 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=S)Nc1ccc(O)c(NC(=O)CNC(=O)CSC(c2ccccc2)(c2ccccc2)c2ccccc2)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.ejmech.2009.09.043
70697518 77804 None 0 Human Functional pIC50 = 4 4.0 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 10.1021/jm00390a019
CHEMBL2092748 77804 None 0 Human Functional pIC50 = 4 4.0 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@@H]1CNc2ccccc21 10.1021/jm00390a019
44281084 112690 None 0 Human Functional pIC50 = 6.0 6.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33043 112690 None 0 Human Functional pIC50 = 6.0 6.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280368 96895 None 0 Human Functional pIC50 = 6.0 6.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL265740 96895 None 0 Human Functional pIC50 = 6.0 6.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
44280992 100117 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL287564 100117 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
44280620 103914 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
CHEMBL30924 103914 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
44280113 168228 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
CHEMBL433623 168228 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
44280895 168094 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL432679 168094 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44212546 99926 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL286228 99926 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280314 169692 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL443781 169692 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
13822916 189724 None 0 Human Functional pIC50 = 4.9 4.9 -39 3
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL51569 189724 None 0 Human Functional pIC50 = 4.9 4.9 -39 3
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00390a019
65987 99575 None 13 Human Functional pIC50 = 5.9 5.9 10 2
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283820 99575 None 13 Human Functional pIC50 = 5.9 5.9 10 2
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280179 103019 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30696 103019 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
44280090 99534 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283460 99534 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280245 100033 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
CHEMBL286941 100033 None 0 Human Functional pIC50 = 7.9 7.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
656755 67708 None 32 Human Functional pIC50 = 4.9 4.9 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 397 3 1 2 4.7 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907717 67708 None 32 Human Functional pIC50 = 4.9 4.9 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 397 3 1 2 4.7 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15167802 67710 None 0 Human Functional pIC50 = 4.9 4.9 2 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 436 5 1 3 5.0 N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907720 67710 None 0 Human Functional pIC50 = 4.9 4.9 2 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 436 5 1 3 5.0 N#CCCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15614841 67719 None 0 Human Functional pIC50 = 4.9 4.9 6 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 390 5 1 3 4.7 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 10.1021/jm00390a019
CHEMBL1907734 67719 None 0 Human Functional pIC50 = 4.9 4.9 6 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 390 5 1 3 4.7 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1COCc1ccccc1 10.1021/jm00390a019
15614739 75418 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 350 3 1 3 4.3 O=C1Nc2ccccc2C(c2ccccc2F)=NC1Cc1ccsc1 10.1021/jm00390a019
CHEMBL20408 75418 None 0 Human Functional pIC50 = 4.9 4.9 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 350 3 1 3 4.3 O=C1Nc2ccccc2C(c2ccccc2F)=NC1Cc1ccsc1 10.1021/jm00390a019
20063212 167139 None 0 Human Functional pIC50 = 4.9 4.9 3 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 395 3 0 3 4.5 CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 10.1021/jm00390a019
CHEMBL429063 167139 None 0 Human Functional pIC50 = 4.9 4.9 3 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 395 3 0 3 4.5 CN1CC(CC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c2ccccc21 10.1021/jm00390a019
44279853 104791 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
CHEMBL31093 104791 None 0 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
44418923 161783 None 0 Human Functional pIC50 = 7.8 7.8 -5 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL414087 161783 None 0 Human Functional pIC50 = 7.8 7.8 -5 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44280622 119212 None 0 Human Functional pIC50 = 7.8 7.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
CHEMBL34332 119212 None 0 Human Functional pIC50 = 7.8 7.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
44280374 102865 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
CHEMBL30575 102865 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
44280510 102953 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30639 102953 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
44280406 119524 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
CHEMBL34569 119524 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
44280598 100491 None 0 Human Functional pIC50 = 7.8 7.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL291001 100491 None 0 Human Functional pIC50 = 7.8 7.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280399 103093 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30756 103093 None 0 Human Functional pIC50 = 6.8 6.8 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
44396655 122048 None 0 Human Functional pIC50 = 5.8 5.8 3 2
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 122048 None 0 Human Functional pIC50 = 5.8 5.8 3 2
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
70697534 77845 None 0 Human Functional pIC50 = 4.8 4.8 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 10.1021/jm00390a019
CHEMBL2092989 77845 None 0 Human Functional pIC50 = 4.8 4.8 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 367 3 2 3 4.4 O=C1Nc2ccccc2C(c2ccccc2)=NC1C[C@H]1CNc2ccccc21 10.1021/jm00390a019
44280131 99590 None 0 Human Functional pIC50 = 7.7 7.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL283914 99590 None 0 Human Functional pIC50 = 7.7 7.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280177 99487 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283204 99487 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
5311201 207393 None 35 Human Functional pIC50 = 8.7 8.7 1 7
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00067a001
CHEMBL9387 207393 None 35 Human Functional pIC50 = 8.7 8.7 1 7
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00067a001
44280915 100277 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL289008 100277 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44279852 99360 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282476 99360 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
15167824 67717 None 0 Human Functional pIC50 = 4.7 4.7 -2 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 379 3 1 2 4.6 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
CHEMBL1907731 67717 None 0 Human Functional pIC50 = 4.7 4.7 -2 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 379 3 1 2 4.6 CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
44396746 127058 None 0 Human Functional pIC50 = 5.7 5.7 -16 2
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 127058 None 0 Human Functional pIC50 = 5.7 5.7 -16 2
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44351469 116933 None 0 Rat Functional pIC50 = 6.7 6.7 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338526 116933 None 0 Rat Functional pIC50 = 6.7 6.7 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44280316 96762 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL264606 96762 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
15614824 67727 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 453 6 1 2 6.1 CC(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907743 67727 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 453 6 1 2 6.1 CC(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
44280893 99234 None 0 Human Functional pIC50 = 6.6 6.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281671 99234 None 0 Human Functional pIC50 = 6.6 6.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280193 103129 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30784 103129 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44279938 162623 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
CHEMBL416944 162623 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
15167783 67720 None 0 Human Functional pIC50 = 4.6 4.6 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 409 4 3 3 4.3 O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
CHEMBL1907735 67720 None 0 Human Functional pIC50 = 4.6 4.6 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 409 4 3 3 4.3 O=C(O)c1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
44280110 102888 None 0 Human Functional pIC50 = 6.6 6.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30592 102888 None 0 Human Functional pIC50 = 6.6 6.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280112 99593 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
CHEMBL283924 99593 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
15614830 67716 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 469 6 1 4 4.7 CCOC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907730 67716 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 469 6 1 4 4.7 CCOC(=O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15614828 67718 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 454 6 1 3 4.7 CN(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907733 67718 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 454 6 1 3 4.7 CN(C)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
44280130 161277 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
CHEMBL412108 161277 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
CHEMBL375360 212216 None 4 Human Functional pIC50 = 7.6 7.6 1 2
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm061268p
44280163 104371 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31018 104371 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280974 100005 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL286763 100005 None 0 Human Functional pIC50 = 7.6 7.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
15167770 67723 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 369 3 2 2 5.2 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)CNc2ccccc21 10.1021/jm00390a019
CHEMBL1907738 67723 None 0 Human Functional pIC50 = 4.6 4.6 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 369 3 2 2 5.2 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)CNc2ccccc21 10.1021/jm00390a019
44280363 102338 None 0 Human Functional pIC50 = 5.6 5.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30369 102338 None 0 Human Functional pIC50 = 5.6 5.6 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
108187 925 None 37 Rat Functional pIC50 = 7.5 7.5 -91 5
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
873 925 None 37 Rat Functional pIC50 = 7.5 7.5 -91 5
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL2062154 925 None 37 Rat Functional pIC50 = 7.5 7.5 -91 5
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL287735 925 None 37 Rat Functional pIC50 = 7.5 7.5 -91 5
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
9865694 204174 None 0 Human Functional pIC50 = 4.5 4.5 -8 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL70728 204174 None 0 Human Functional pIC50 = 4.5 4.5 -8 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44280509 99402 None 0 Human Functional pIC50 = 6.5 6.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
CHEMBL282732 99402 None 0 Human Functional pIC50 = 6.5 6.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
44280178 102620 None 0 Human Functional pIC50 = 7.5 7.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30422 102620 None 0 Human Functional pIC50 = 7.5 7.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280694 100278 None 0 Human Functional pIC50 = 6.5 6.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL289018 100278 None 0 Human Functional pIC50 = 6.5 6.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280246 102162 None 0 Human Functional pIC50 = 7.5 7.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
CHEMBL30262 102162 None 0 Human Functional pIC50 = 7.5 7.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
44280123 99271 None 0 Human Functional pIC50 = 7.5 7.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281903 99271 None 0 Human Functional pIC50 = 7.5 7.5 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280397 103674 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30875 103674 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280233 99206 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281490 99206 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44279937 104860 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31101 104860 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44351445 116932 None 0 Rat Functional pIC50 = 7.4 7.4 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 116932 None 0 Rat Functional pIC50 = 7.4 7.4 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
44280234 102283 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
CHEMBL30335 102283 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
15556550 67721 None 0 Human Functional pIC50 = 4.4 4.4 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 326 3 1 2 4.5 CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O 10.1021/jm00390a019
CHEMBL1907736 67721 None 0 Human Functional pIC50 = 4.4 4.4 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 326 3 1 2 4.5 CC(C)C[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O 10.1021/jm00390a019
44351444 116884 None 0 Rat Functional pIC50 = 6.4 6.4 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 116884 None 0 Rat Functional pIC50 = 6.4 6.4 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
5311201 207393 None 35 Rat Functional pIC50 = 7.4 7.4 -7 7
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL9387 207393 None 35 Rat Functional pIC50 = 7.4 7.4 -7 7
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
44280502 99384 None 0 Human Functional pIC50 = 6.4 6.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL282639 99384 None 0 Human Functional pIC50 = 6.4 6.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
44418924 156880 None 0 Human Functional pIC50 = 8.3 8.3 -8 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 156880 None 0 Human Functional pIC50 = 8.3 8.3 -8 5
Activity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to controlActivity at human CCK2 receptor expressed in HEK293 cells assessed as level of [3H]inositol produced relative to control
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
9800177 67707 None 0 Human Functional pIC50 = 4.4 4.4 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 383 3 2 2 4.7 O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL1907714 67707 None 0 Human Functional pIC50 = 4.4 4.4 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 383 3 2 2 4.7 O=C1Nc2ccccc2C(c2ccccc2F)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44280350 99850 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285739 99850 None 0 Human Functional pIC50 = 7.4 7.4 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44396745 125036 None 0 Human Functional pIC50 = 5.4 5.4 -4 2
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 125036 None 0 Human Functional pIC50 = 5.4 5.4 -4 2
Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptorInhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
44280894 113508 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33209 113508 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280381 102942 None 0 Human Functional pIC50 = 6.3 6.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30634 102942 None 0 Human Functional pIC50 = 6.3 6.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280111 99967 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
CHEMBL286510 99967 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
15614734 67715 None 1 Human Functional pIC50 = 4.3 4.3 -2 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 411 3 0 3 4.7 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907729 67715 None 1 Human Functional pIC50 = 4.3 4.3 -2 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 411 3 0 3 4.7 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15167776 67714 None 0 Human Functional pIC50 = 5.3 5.3 4 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 441 5 2 3 4.2 O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907728 67714 None 0 Human Functional pIC50 = 5.3 5.3 4 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 441 5 2 3 4.2 O=C(O)CN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
14444002 121052 None 0 Human Functional pIC50 = 5.3 5.3 - 1
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL356844 121052 None 0 Human Functional pIC50 = 5.3 5.3 - 1
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
15614807 67725 None 1 Human Functional pIC50 = 4.3 4.3 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 365 3 2 2 4.6 O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL1907740 67725 None 1 Human Functional pIC50 = 4.3 4.3 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 365 3 2 2 4.6 O=C1Nc2ccccc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44351446 156139 None 0 Rat Functional pIC50 = 6.3 6.3 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 156139 None 0 Rat Functional pIC50 = 6.3 6.3 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44279957 99209 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL281507 99209 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280091 168436 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL434967 168436 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280244 13224 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL1191257 13224 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL542330 13224 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
44280103 167956 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL431692 167956 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
44280315 101617 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL29891 101617 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280102 102707 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30481 102707 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280387 119766 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL34797 119766 None 0 Human Functional pIC50 = 7.3 7.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
44351455 116817 None 0 Rat Functional pIC50 = 7.3 7.3 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337934 116817 None 0 Rat Functional pIC50 = 7.3 7.3 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351454 116816 None 0 Rat Functional pIC50 = 7.3 7.3 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337933 116816 None 0 Rat Functional pIC50 = 7.3 7.3 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44280375 99106 None 0 Human Functional pIC50 = 6.3 6.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL280832 99106 None 0 Human Functional pIC50 = 6.3 6.3 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
44280621 103923 None 0 Human Functional pIC50 = 7.2 7.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL30926 103923 None 0 Human Functional pIC50 = 7.2 7.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
15167804 67709 None 0 Human Functional pIC50 = 5.2 5.2 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 455 6 2 3 4.6 O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
CHEMBL1907719 67709 None 0 Human Functional pIC50 = 5.2 5.2 1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 455 6 2 3 4.6 O=C(O)CCN1C(=O)[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00390a019
15614820 67722 None 0 Human Functional pIC50 = 4.2 4.2 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 437 5 1 2 5.5 O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 10.1021/jm00390a019
CHEMBL1907737 67722 None 0 Human Functional pIC50 = 4.2 4.2 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 437 5 1 2 5.5 O=C1[C@@H](Cc2c[nH]c3ccccc23)N=C(c2ccccc2F)c2ccccc2N1CC1CC1 10.1021/jm00390a019
44280000 103251 None 0 Human Functional pIC50 = 6.2 6.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30844 103251 None 0 Human Functional pIC50 = 6.2 6.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
15167820 67712 None 0 Human Functional pIC50 = 4.2 4.2 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 393 3 0 3 4.6 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
CHEMBL1907724 67712 None 0 Human Functional pIC50 = 4.2 4.2 -1 2
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 393 3 0 3 4.6 CN1C(=O)[C@@H](Cc2cn(C)c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00390a019
44280599 99160 None 0 Human Functional pIC50 = 8.2 8.2 630 2
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL281206 99160 None 0 Human Functional pIC50 = 8.2 8.2 630 2
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280122 99497 None 0 Human Functional pIC50 = 8.2 8.2 169 2
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL283276 99497 None 0 Human Functional pIC50 = 8.2 8.2 169 2
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280993 118335 None 0 Human Functional pIC50 = 7.2 7.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL34101 118335 None 0 Human Functional pIC50 = 7.2 7.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
39760 67763 None 3 Human Functional pIC50 = 4.2 4.2 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
CHEMBL1907931 67763 None 3 Human Functional pIC50 = 4.2 4.2 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@H]1Cc1c[nH]c2ccccc12 10.1021/jm00390a019
44280398 99243 None 0 Human Functional pIC50 = 7.2 7.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281728 99243 None 0 Human Functional pIC50 = 7.2 7.2 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44351519 168517 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL435404 168517 None 0 Rat Functional pIC50 = 7.1 7.1 - 1
Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44280508 99824 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285559 99824 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280205 13066 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL1190133 13066 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL540261 13066 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
44280729 168227 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
CHEMBL433621 168227 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
168269598 190007 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 325 6 0 4 3.3 C#CCOC1OC(=O)C(Cl)=C1N(CC(C)C)C1CCCCC1 10.1016/j.bmc.2022.116815
CHEMBL5171437 190007 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 325 6 0 4 3.3 C#CCOC1OC(=O)C(Cl)=C1N(CC(C)C)C1CCCCC1 10.1016/j.bmc.2022.116815
44280507 113494 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
CHEMBL33200 113494 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
136067266 67724 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 303 2 2 2 3.5 CC1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
CHEMBL1907739 67724 None 0 Human Functional pIC50 = 4.1 4.1 - 1
Half-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glandsHalf-maximal inhibition of binding of [125I]gastrin to guinea pig gastric glands
ChEMBL 303 2 2 2 3.5 CC1=N[C@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccccc21 10.1021/jm00390a019
4355450 135925 None 50 Human Functional pIC50 = 7.1 7.1 -12 3
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00067a001
CHEMBL37312 135925 None 50 Human Functional pIC50 = 7.1 7.1 -12 3
Antagonistic activity against cholecystokinin type B receptorAntagonistic activity against cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00067a001
44280270 99216 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281560 99216 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
168286058 191319 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 295 6 1 4 2.8 CC(C)CNC1=C(Cl)C(=O)OC1OCc1ccccc1 10.1016/j.bmc.2022.116815
CHEMBL5191421 191319 None 0 Human Functional pIC50 = 7.1 7.1 - 1
Antagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysisAntagonist activity at pig cerebral cortex CCK2 human by Packbard-Cobra counter analysis
ChEMBL 295 6 1 4 2.8 CC(C)CNC1=C(Cl)C(=O)OC1OCc1ccccc1 10.1016/j.bmc.2022.116815
44280176 99308 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282099 99308 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280973 99865 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL285857 99865 None 0 Human Functional pIC50 = 7.1 7.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
44280269 99215 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281559 99215 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44279939 99315 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL282149 99315 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
44280501 100021 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
CHEMBL286847 100021 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
44280414 101857 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
CHEMBL30061 101857 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
44280407 119709 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL34743 119709 None 0 Human Functional pIC50 = 8.1 8.1 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280380 99838 None 0 Human Functional pIC50 = 7.0 7.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285657 99838 None 0 Human Functional pIC50 = 7.0 7.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44280101 99591 None 0 Human Functional pIC50 = 7.0 7.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
CHEMBL283920 99591 None 0 Human Functional pIC50 = 7.0 7.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
44279985 103101 None 0 Human Functional pIC50 = 6 6.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL30764 103101 None 0 Human Functional pIC50 = 6 6.0 - 1
In vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cellsIn vitro inhibition of gastrin-induced [Ca2+] cytosolic elevation in isolated rabbit parietal cells
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
887 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
9870520 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
CHEMBL324547 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
DB12355 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
887 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
9870520 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
CHEMBL324547 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
DB12355 4108 None 33 Rat Functional pKd = 10.1 10.1 1 3
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
11498528 72474 None 0 Rat Functional pKd = 9.2 9.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL198933 72474 None 0 Rat Functional pKd = 9.2 9.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16732163 142062 None 0 Rat Functional pKd = 9.1 9.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL387948 142062 None 0 Rat Functional pKd = 9.1 9.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
16732164 143301 None 0 Rat Functional pKd = 9.1 9.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389711 143301 None 0 Rat Functional pKd = 9.1 9.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9832467 144291 None 0 Rat Functional pKd = 9.1 9.1 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL390519 144291 None 0 Rat Functional pKd = 9.1 9.1 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
9832467 144291 None 0 Rat Functional pKd = 9.1 9.1 - 1
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL390519 144291 None 0 Rat Functional pKd = 9.1 9.1 - 1
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
11555184 166030 None 0 Rat Functional pKd = 9.1 9.1 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL425574 166030 None 0 Rat Functional pKd = 9.1 9.1 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
11527738 75987 None 0 Rat Functional pKd = 9.0 9.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205455 75987 None 0 Rat Functional pKd = 9.0 9.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11527738 75987 None 0 Rat Functional pKd = 9.0 9.0 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL205455 75987 None 0 Rat Functional pKd = 9.0 9.0 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16733466 85515 None 0 Rat Functional pKd = 8.9 8.9 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227330 85515 None 0 Rat Functional pKd = 8.9 8.9 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
11605814 75426 None 0 Rat Functional pKd = 8.9 8.9 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL204154 75426 None 0 Rat Functional pKd = 8.9 8.9 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16733469 85516 None 0 Rat Functional pKd = 8.8 8.8 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227333 85516 None 0 Rat Functional pKd = 8.8 8.8 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
11571142 135804 None 0 Rat Functional pKd = 8.8 8.8 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
CHEMBL373050 135804 None 0 Rat Functional pKd = 8.8 8.8 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
135423404 85510 None 0 Rat Functional pKd = 8.7 8.7 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL227276 85510 None 0 Rat Functional pKd = 8.7 8.7 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
16731872 85447 None 0 Rat Functional pKd = 8.7 8.7 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226620 85447 None 0 Rat Functional pKd = 8.7 8.7 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
11679213 133541 None 0 Rat Functional pKd = 8 8.0 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL370882 133541 None 0 Rat Functional pKd = 8 8.0 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11568611 71977 None 0 Rat Functional pKd = 8.0 8.0 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197370 71977 None 0 Rat Functional pKd = 8.0 8.0 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11571166 141312 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL383386 141312 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11592162 76527 None 0 Rat Functional pKd = 7.0 7.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206079 76527 None 0 Rat Functional pKd = 7.0 7.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11699148 75979 None 0 Rat Functional pKd = 6.0 6.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
CHEMBL205423 75979 None 0 Rat Functional pKd = 6.0 6.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
11584903 140737 None 0 Rat Functional pKd = 6.9 6.9 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL381805 140737 None 0 Rat Functional pKd = 6.9 6.9 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11505466 72028 None 0 Rat Functional pKd = 5.9 5.9 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
CHEMBL197578 72028 None 0 Rat Functional pKd = 5.9 5.9 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
44451547 96710 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
CHEMBL264150 96710 None 0 Rat Functional pKd = 7.9 7.9 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
11613212 72099 None 0 Rat Functional pKd = 7.9 7.9 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL197780 72099 None 0 Rat Functional pKd = 7.9 7.9 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11663308 76743 None 1 Rat Functional pKd = 6.9 6.9 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206709 76743 None 1 Rat Functional pKd = 6.9 6.9 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11613982 140423 None 0 Rat Functional pKd = 6.8 6.8 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380907 140423 None 0 Rat Functional pKd = 6.8 6.8 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11567687 135935 None 0 Rat Functional pKd = 5.8 5.8 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL373125 135935 None 0 Rat Functional pKd = 5.8 5.8 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11656338 75943 None 0 Rat Functional pKd = 7.8 7.8 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205198 75943 None 0 Rat Functional pKd = 7.8 7.8 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11628273 140132 None 0 Rat Functional pKd = 7.7 7.7 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380193 140132 None 0 Rat Functional pKd = 7.7 7.7 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
44451920 96124 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL260394 96124 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
11495719 70371 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
CHEMBL194514 70371 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
44451877 95979 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
CHEMBL259557 95979 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
11513177 72527 None 0 Rat Functional pKd = 8.6 8.6 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL199091 72527 None 0 Rat Functional pKd = 8.6 8.6 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16732911 143214 None 0 Rat Functional pKd = 8.6 8.6 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389639 143214 None 0 Rat Functional pKd = 8.6 8.6 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11539356 71678 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196441 71678 None 0 Rat Functional pKd = 7.7 7.7 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11705988 166350 None 0 Rat Functional pKd = 6.7 6.7 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL427387 166350 None 0 Rat Functional pKd = 6.7 6.7 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16732020 85508 None 0 Rat Functional pKd = 7.6 7.6 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
CHEMBL227254 85508 None 0 Rat Functional pKd = 7.6 7.6 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
11612498 133560 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL371068 133560 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
11685703 71918 None 0 Rat Functional pKd = 7.6 7.6 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
CHEMBL197205 71918 None 0 Rat Functional pKd = 7.6 7.6 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
44451622 95914 None 0 Rat Functional pKd = 7.6 7.6 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL259276 95914 None 0 Rat Functional pKd = 7.6 7.6 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11712880 138921 None 0 Rat Functional pKd = 7.6 7.6 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL378388 138921 None 0 Rat Functional pKd = 7.6 7.6 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11511721 76100 None 0 Rat Functional pKd = 7.6 7.6 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205751 76100 None 0 Rat Functional pKd = 7.6 7.6 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11555166 139828 None 0 Rat Functional pKd = 7.5 7.5 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL379902 139828 None 0 Rat Functional pKd = 7.5 7.5 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
5311201 207393 None 35 Rat Functional pKd = 7.5 7.5 -7 7
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
CHEMBL9387 207393 None 35 Rat Functional pKd = 7.5 7.5 -7 7
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
135529065 157013 None 0 Rat Functional pKd = 8.5 8.5 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL407340 157013 None 0 Rat Functional pKd = 8.5 8.5 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11497371 70628 None 0 Rat Functional pKd = 8.5 8.5 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL195007 70628 None 0 Rat Functional pKd = 8.5 8.5 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11605694 168651 None 0 Rat Functional pKd = 7.5 7.5 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL436314 168651 None 0 Rat Functional pKd = 7.5 7.5 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
11576771 74429 None 0 Rat Functional pKd = 7.4 7.4 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL202680 74429 None 0 Rat Functional pKd = 7.4 7.4 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
44451581 95823 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258863 95823 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
16731874 85456 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226675 85456 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11540160 71446 None 0 Rat Functional pKd = 8.3 8.3 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196133 71446 None 0 Rat Functional pKd = 8.3 8.3 - 1
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44451843 159437 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL410114 159437 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
136036823 155676 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL404967 155676 None 0 Rat Functional pKd = 7.4 7.4 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11571140 71699 None 0 Rat Functional pKd = 8.3 8.3 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196517 71699 None 0 Rat Functional pKd = 8.3 8.3 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
11512112 75590 None 0 Rat Functional pKd = 7.3 7.3 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
CHEMBL204683 75590 None 0 Rat Functional pKd = 7.3 7.3 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
11643045 72136 None 0 Rat Functional pKd = 6.3 6.3 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197873 72136 None 0 Rat Functional pKd = 6.3 6.3 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11698512 168253 None 0 Rat Functional pKd = 7.3 7.3 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL433776 168253 None 0 Rat Functional pKd = 7.3 7.3 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11542079 71720 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196580 71720 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11518283 166158 None 0 Rat Functional pKd = 8.2 8.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL426290 166158 None 0 Rat Functional pKd = 8.2 8.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16732753 143984 None 0 Rat Functional pKd = 8.1 8.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL390276 143984 None 0 Rat Functional pKd = 8.1 8.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732019 85432 None 0 Rat Functional pKd = 8.1 8.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226533 85432 None 0 Rat Functional pKd = 8.1 8.1 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11541870 71449 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196141 71449 None 0 Rat Functional pKd = 7.2 7.2 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44451523 95941 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
CHEMBL259390 95941 None 0 Rat Functional pKd = 6.2 6.2 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
443375 207604 None 45 Rat Functional pKd = 6.1 6.1 -4466 6
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
CHEMBL9506 207604 None 45 Rat Functional pKd = 6.1 6.1 -4466 6
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
11505870 72505 None 0 Rat Functional pKd = 6.1 6.1 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
CHEMBL199032 72505 None 0 Rat Functional pKd = 6.1 6.1 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
11613179 71786 None 0 Rat Functional pKd = 8.1 8.1 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL196745 71786 None 0 Rat Functional pKd = 8.1 8.1 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11511706 72259 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL198225 72259 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachAntagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomach
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
136036821 95806 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258782 95806 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretionAntagonist activity at CCK2 receptor in immature rat stomach assessed as pentagastrin-induced acid secretion
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
11642370 140169 None 0 Rat Functional pKd = 6.1 6.1 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380363 140169 None 0 Rat Functional pKd = 6.1 6.1 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
135610887 85440 None 0 Rat Functional pKd = 8.0 8.0 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226583 85440 None 0 Rat Functional pKd = 8.0 8.0 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732909 85455 None 0 Rat Functional pKd = 8.0 8.0 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226673 85455 None 0 Rat Functional pKd = 8.0 8.0 - 0
Antagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretionAntagonist activity at CCK2 receptor in perfused rat stomach assessed as inhibition of pentagastrin-stimulated gastric acid secretion
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
11663565 76194 None 0 Rat Functional pKd = 7.0 7.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205831 76194 None 0 Rat Functional pKd = 7.0 7.0 - 0
Affinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomachAffinity for CCK2 receptor assessed by inhibition of pentagastrin-stimulated acid secretion in perfused rat stomach
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
9832467 144291 None 0 Dog Functional pKi = 7.9 7.9 - 1
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL390519 144291 None 0 Dog Functional pKi = 7.9 7.9 - 1
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
11527738 75987 None 0 Dog Functional pKi = 7.9 7.9 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL205455 75987 None 0 Dog Functional pKi = 7.9 7.9 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL2370598 209876 None 0 Human Functional pKi = 6.9 6.9 - 0
Ability to displace specific binding of 0.2 nM [3H]Boc[Nle28,31]-CCK27-33 from guinea pig brain membranesAbility to displace specific binding of 0.2 nM [3H]Boc[Nle28,31]-CCK27-33 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16732164 143301 None 0 Dog Functional pKi = 8.6 8.6 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389711 143301 None 0 Dog Functional pKi = 8.6 8.6 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732753 143984 None 0 Dog Functional pKi = 7.6 7.6 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL390276 143984 None 0 Dog Functional pKi = 7.6 7.6 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732019 85432 None 0 Dog Functional pKi = 8.5 8.5 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226533 85432 None 0 Dog Functional pKi = 8.5 8.5 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16733466 85515 None 0 Dog Functional pKi = 8.4 8.4 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227330 85515 None 0 Dog Functional pKi = 8.4 8.4 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
135610887 85440 None 0 Dog Functional pKi = 8.4 8.4 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226583 85440 None 0 Dog Functional pKi = 8.4 8.4 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
135423404 85510 None 0 Dog Functional pKi = 8.4 8.4 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL227276 85510 None 0 Dog Functional pKi = 8.4 8.4 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
16732020 85508 None 0 Dog Functional pKi = 8.3 8.3 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
CHEMBL227254 85508 None 0 Dog Functional pKi = 8.3 8.3 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
16733469 85516 None 0 Dog Functional pKi = 8.3 8.3 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227333 85516 None 0 Dog Functional pKi = 8.3 8.3 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
16732909 85455 None 0 Dog Functional pKi = 8.3 8.3 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226673 85455 None 0 Dog Functional pKi = 8.3 8.3 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732911 143214 None 0 Dog Functional pKi = 8.2 8.2 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389639 143214 None 0 Dog Functional pKi = 8.2 8.2 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732163 142062 None 0 Dog Functional pKi = 8.2 8.2 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL387948 142062 None 0 Dog Functional pKi = 8.2 8.2 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
16731872 85447 None 0 Dog Functional pKi = 8.2 8.2 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226620 85447 None 0 Dog Functional pKi = 8.2 8.2 - 0
Displacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosaDisplacement of [125I]BH-CCK8-8S from CCK2 receptor in canine gastric mucosa
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
5489450 206 None 0 Human Functional pIC50 = 6.5 6.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8914862
894 206 None 0 Human Functional pIC50 = 6.5 6.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8914862
4329839 818 None 0 Human Functional pIC50 = 7.5 7.5 158 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
861 818 None 0 Human Functional pIC50 = 7.5 7.5 158 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
2802894 2401 None 33 Rat Functional pIC50 = 7.5 7.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 21228869
3509 2401 None 33 Rat Functional pIC50 = 7.5 7.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 21228869
CHEMBL333081 2401 None 33 Rat Functional pIC50 = 7.5 7.5 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 21228869
3523 3379 None 0 Rat Functional pIC50 = 8 8.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 554 11 3 6 2.9 COc1cccc(c1)N(C(=O)CNC(=O)Nc1cccc(c1)CCS(=O)(=O)O)CC(=O)N(c1ccccc1)C 10385255
5311414 3379 None 0 Rat Functional pIC50 = 8 8.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 554 11 3 6 2.9 COc1cccc(c1)N(C(=O)CNC(=O)Nc1cccc(c1)CCS(=O)(=O)O)CC(=O)N(c1ccccc1)C 10385255
16168172 1770 None 0 Mouse Functional pIC50 = 8.3 8.3 158 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
3559 1770 None 0 Mouse Functional pIC50 = 8.3 8.3 158 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
104929 2217 None 9 Human Functional pIC50 = 8.4 8.4 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
3477 2217 None 9 Human Functional pIC50 = 8.4 8.4 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
879 2217 None 9 Human Functional pIC50 = 8.4 8.4 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
CHEMBL289498 2217 None 9 Human Functional pIC50 = 8.4 8.4 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
3084441 1393 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
3725 1393 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
11307323 2136 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 546 6 2 5 5.0 Brc1ccc(c(c1)NS(=O)(=O)c1cccc2c1nccn2)C(=O)N[C@@H](c1ccc(cc1F)F)C 21493750
6665 2136 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 546 6 2 5 5.0 Brc1ccc(c(c1)NS(=O)(=O)c1cccc2c1nccn2)C(=O)N[C@@H](c1ccc(cc1F)F)C 21493750
3948 3007 None 0 Rat Functional pIC50 = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8720482
5491702 3007 None 0 Rat Functional pIC50 = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8720482
444007 3041 None 0 Mouse Functional pIC50 = 9.1 9.1 794 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
870 3041 None 0 Mouse Functional pIC50 = 9.1 9.1 794 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
DB00183 3041 None 0 Mouse Functional pIC50 = 9.1 9.1 794 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1975695
132980 2238 None 12 Human Functional pIC50 = 9.2 9.2 6456 2
UnclassifiedUnclassified
Guide to Pharmacology 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 11738246
881 2238 None 12 Human Functional pIC50 = 9.2 9.2 6456 2
UnclassifiedUnclassified
Guide to Pharmacology 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 11738246
CHEMBL420783 2238 None 12 Human Functional pIC50 = 9.2 9.2 6456 2
UnclassifiedUnclassified
Guide to Pharmacology 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 11738246
122130 4113 None 39 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 11738246
888 4113 None 39 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 11738246
CHEMBL115121 4113 None 39 Human Functional pIC50 = 9.2 9.2 -5 4
UnclassifiedUnclassified
Guide to Pharmacology 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 11738246
3503 1891 None 16 Human Functional pIC50 = 9.4 9.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 11020274
5311147 1891 None 16 Human Functional pIC50 = 9.4 9.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 11020274
CHEMBL329305 1891 None 16 Human Functional pIC50 = 9.4 9.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 11020274
862 819 None 0 Mouse Functional pIC50 = 9.5 9.5 1 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12370550
887 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
887 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
9870520 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
9870520 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
CHEMBL324547 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
CHEMBL324547 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
DB12355 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 22607579
DB12355 4108 None 33 Human Functional pIC50 = 9.7 9.7 -1 3
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 9042983
44457632 3025 None 0 Mouse Functional pIC50 None 10.1 10.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 575 10 4 4 5.4 OC(=O)CC(NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccc(cc1)F 8931944
905 3025 None 0 Mouse Functional pIC50 None 10.1 10.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 575 10 4 4 5.4 OC(=O)CC(NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccc(cc1)F 8931944
3960 2343 None 23 Human Functional pIC50 None 5.5 5.5 -131 4
UnclassifiedUnclassified
Guide to Pharmacology 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 8914862
891 2343 None 23 Human Functional pIC50 None 5.5 5.5 -131 4
UnclassifiedUnclassified
Guide to Pharmacology 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 8914862
CHEMBL24938 2343 None 23 Human Functional pIC50 None 5.5 5.5 -131 4
UnclassifiedUnclassified
Guide to Pharmacology 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 8914862
5311148 1894 None 7 Human Functional pIC50 None 6 6.0 -41 2
UnclassifiedUnclassified
Guide to Pharmacology 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 9276016
865 1894 None 7 Human Functional pIC50 None 6 6.0 -41 2
UnclassifiedUnclassified
Guide to Pharmacology 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 9276016
CHEMBL293226 1894 None 7 Human Functional pIC50 None 6 6.0 -41 2
UnclassifiedUnclassified
Guide to Pharmacology 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 9276016
904 3024 None 10 Rat Functional pIC50 None 6.6 6.6 -44 3
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
9915756 3024 None 10 Rat Functional pIC50 None 6.6 6.6 -44 3
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
CHEMBL2111204 3024 None 10 Rat Functional pIC50 None 6.6 6.6 -44 3
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
CHEMBL356898 3024 None 10 Rat Functional pIC50 None 6.6 6.6 -44 3
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 7684452
54695534 3787 None 5 Human Functional pIC50 None 6.7 6.7 -54 2
UnclassifiedUnclassified
Guide to Pharmacology 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 8233061
910 3787 None 5 Human Functional pIC50 None 6.7 6.7 -54 2
UnclassifiedUnclassified
Guide to Pharmacology 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 8233061
CHEMBL3576924 3787 None 5 Human Functional pIC50 None 6.7 6.7 -54 2
UnclassifiedUnclassified
Guide to Pharmacology 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 8233061
3476 1399 None 9 Human Functional pIC50 None 6.8 6.8 -870 2
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
59751 1399 None 9 Human Functional pIC50 None 6.8 6.8 -870 2
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
878 1399 None 9 Human Functional pIC50 None 6.8 6.8 -870 2
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
CHEMBL39263 1399 None 9 Human Functional pIC50 None 6.8 6.8 -870 2
UnclassifiedUnclassified
Guide to Pharmacology 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 7681836
6956374 2403 None 5 Human Functional pIC50 None 7 7.0 3 3
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 8914862
902 2403 None 5 Human Functional pIC50 None 7 7.0 3 3
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 8914862
CHEMBL117281 2403 None 5 Human Functional pIC50 None 7 7.0 3 3
UnclassifiedUnclassified
Guide to Pharmacology 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 8914862
898 2123 None 0 Rat Functional pIC50 None 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1698251
3074331 924 None 0 Mouse Functional pIC50 None 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 493 6 4 4 4.6 O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 9438020
872 924 None 0 Mouse Functional pIC50 None 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 493 6 4 4 4.6 O=C(N[C@@](C(=O)N[C@H]1CCCC[C@@H]1O)(Cc1c[nH]c2c1cccc2)C)OC12CC3CC(C2)CC(C1)C3 9438020
6604121 2103 None 23 Rat Functional pIC50 None 8.6 8.6 15848 2
UnclassifiedUnclassified
Guide to Pharmacology 526 7 2 3 6.8 OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C 10204685
909 2103 None 23 Rat Functional pIC50 None 8.6 8.6 15848 2
UnclassifiedUnclassified
Guide to Pharmacology 526 7 2 3 6.8 OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C 10204685
CHEMBL1256717 2103 None 23 Rat Functional pIC50 None 8.6 8.6 15848 2
UnclassifiedUnclassified
Guide to Pharmacology 526 7 2 3 6.8 OC(=O)C[C@H](c1cccc2c1cccc2)CC(=O)Nc1c(C)cc(cc1C(=O)N1CCC2(CC1)CCCC2)C 10204685
16129670 814 None 0 Human Functional pIC50 None 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
860 814 None 0 Human Functional pIC50 None 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
91898395 814 None 0 Human Functional pIC50 None 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
108187 925 None 37 Mouse Functional pIC50 None 8.8 8.8 -67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
873 925 None 37 Mouse Functional pIC50 None 8.8 8.8 -67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
CHEMBL2062154 925 None 37 Mouse Functional pIC50 None 8.8 8.8 -67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
CHEMBL287735 925 None 37 Mouse Functional pIC50 None 8.8 8.8 -67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 1975695
122119 3021 None 0 Human Functional pIC50 None 8.9 8.9 1000 2
UnclassifiedUnclassified
Guide to Pharmacology 618 12 5 6 5.1 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O 8914862
882 3021 None 0 Human Functional pIC50 None 8.9 8.9 1000 2
UnclassifiedUnclassified
Guide to Pharmacology 618 12 5 6 5.1 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](CC1CNc2c1cccc2)(NC(=O)OC1C[C@H]2C([C@]1(C)CC2)(C)C)C)CCC(=O)O 8914862
108187 925 None 37 Human Functional pIC50 None 9.1 9.1 67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
873 925 None 37 Human Functional pIC50 None 9.1 9.1 67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
CHEMBL2062154 925 None 37 Human Functional pIC50 None 9.1 9.1 67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
CHEMBL287735 925 None 37 Human Functional pIC50 None 9.1 9.1 67 5
UnclassifiedUnclassified
Guide to Pharmacology 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 8914862
5311016 591 None 0 Rat Functional pIC50 None 9.5 9.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
897 591 None 0 Rat Functional pIC50 None 9.5 9.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
903 3022 None 9 Mouse Functional pIC50 None 9.8 9.8 123 2
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
9850711 3022 None 9 Mouse Functional pIC50 None 9.8 9.8 123 2
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
CHEMBL138534 3022 None 9 Mouse Functional pIC50 None 9.8 9.8 123 2
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
CHEMBL2111312 3022 None 9 Mouse Functional pIC50 None 9.8 9.8 123 2
UnclassifiedUnclassified
Guide to Pharmacology 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 8605955
4627 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
4627 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
864 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
864 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
9833444 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
9833444 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
CHEMBL1121 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
CHEMBL1121 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705
DB09142 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7681836
DB09142 821 None 50 Human Functional pIC50 None 10.0 10.0 -1 6
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349705


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
41684 31219 None 105 Human Binding pAC50 = 5 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 31219 None 105 Human Binding pAC50 = 5 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
4494 190185 None 87 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
CHEMBL517427 190185 None 87 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 385 5 1 8 2.5 COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 10.1038/s41467-023-40064-9
6479523 46440 None 48 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 5 4 6 0.1 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 10.1038/s41467-023-40064-9
CHEMBL1537 46440 None 48 Human Binding pAC50 = 4.9 4.9 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 461 5 4 6 0.1 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 10.1038/s41467-023-40064-9
6436173 55114 None 45 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 55114 None 45 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
3899 207772 None 119 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
CHEMBL960 207772 None 119 Human Binding pAC50 = 4.8 4.8 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 270 2 1 3 3.3 Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1038/s41467-023-40064-9
148124 207097 None 86 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1038/s41467-023-40064-9
CHEMBL3545252 207097 None 86 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1038/s41467-023-40064-9
CHEMBL92 207097 None 86 Human Binding pAC50 = 4.7 4.7 - 1
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1038/s41467-023-40064-9
3883 183533 None 112 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL480 183533 None 112 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
50922675 112582 None 54 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 539 9 3 9 3.9 COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 10.1038/s41467-023-40064-9
CHEMBL3301612 112582 None 54 Human Binding pAC50 = 4.7 4.7 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 539 9 3 9 3.9 COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 10.1038/s41467-023-40064-9
228 445 None 28 Human Binding pAC50 = 4.6 4.6 - 24
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
33 445 None 28 Human Binding pAC50 = 4.6 4.6 - 24
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
6005 445 None 28 Human Binding pAC50 = 4.6 4.6 - 24
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
CHEMBL53 445 None 28 Human Binding pAC50 = 4.6 4.6 - 24
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
DB00714 445 None 28 Human Binding pAC50 = 4.6 4.6 - 24
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 267 0 2 3 2.9 CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O 10.1038/s41467-023-40064-9
40973 46033 None 70 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
CHEMBL1533 46033 None 70 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 310 1 1 1 4.9 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC 10.1038/s41467-023-40064-9
3401 78281 None 80 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
CHEMBL2107430 78281 None 80 Human Binding pAC50 = 4.6 4.6 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 346 4 0 2 5.0 Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 10.1038/s41467-023-40064-9
1016 3745 None 78 Human Binding pAC50 = 4.6 4.6 - 35
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2561 3745 None 78 Human Binding pAC50 = 4.6 4.6 - 35
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2733526 3745 None 78 Human Binding pAC50 = 4.6 4.6 - 35
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
5384 3745 None 78 Human Binding pAC50 = 4.6 4.6 - 35
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL83 3745 None 78 Human Binding pAC50 = 4.6 4.6 - 35
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
DB00675 3745 None 78 Human Binding pAC50 = 4.6 4.6 - 35
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2812 4777 None 101 Human Binding pAC50 = 4.5 4.5 - 34
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
CHEMBL104 4777 None 101 Human Binding pAC50 = 4.5 4.5 - 34
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 10.1038/s41467-023-40064-9
104850 3328 None 96 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
4150 3328 None 96 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
743 3328 None 96 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
CHEMBL111 3328 None 96 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
DB06155 3328 None 96 Human Binding pAC50 = 4.5 4.5 - 6
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 462 4 1 4 5.9 Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 10.1038/s41467-023-40064-9
2540 4399 None 111 Human Binding pAC50 = 4.5 4.5 - 4
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 4399 None 111 Human Binding pAC50 = 4.5 4.5 - 4
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
3784 57170 None 101 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
CHEMBL1648 57170 None 101 Human Binding pAC50 = 4.5 4.5 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 4 1 8 2.6 COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc2nonc12 10.1038/s41467-023-40064-9
64139 84783 None 96 Human Binding pAC50 = 4.4 4.4 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
CHEMBL223228 84783 None 96 Human Binding pAC50 = 4.4 4.4 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 315 0 1 2 4.1 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 10.1038/s41467-023-40064-9
3380 22788 None 34 Human Binding pAC50 = 4.3 4.3 - 1
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 2 0 4 2.5 CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21 10.1038/s41467-023-40064-9
CHEMBL13280 22788 None 34 Human Binding pAC50 = 4.3 4.3 - 1
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 313 2 0 4 2.5 CN1C(=O)CN=C(c2ccccc2F)c2cc([N+](=O)[O-])ccc21 10.1038/s41467-023-40064-9
2194 63081 None 101 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL178862 63081 None 101 Human Binding pAC50 = 5.3 5.3 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
1209 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
203 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3386 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL41 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
DB00472 1656 None 75 Human Binding pAC50 = 5.1 5.1 - 32
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
10034073 17159 None 29 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1255800 17159 None 29 Human Binding pAC50 = 5.1 5.1 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 1056 13 7 18 6.2 CCc1c(Cl)c(O)c(Cl)c(O)c1C(=O)O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C2=C\C=C\C[C@H](O)/C(C)=C/[C@H](CC)[C@@H](O[C@@H]3OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]3O)/C(C)=C/C(C)=C/C[C@@H]([C@@H](C)O)OC2=O)O[C@@H]1C 10.1038/s41467-023-40064-9
135564886 14491 None 5 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
135673376 14491 None 5 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
137157436 14491 None 5 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
145948239 14491 None 5 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
71587099 14491 None 5 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
CHEMBL1201304 14491 None 5 Human Binding pAC50 = 5.0 5.0 - 0
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 752 14 1 6 8.7 CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 10.1038/s41467-023-40064-9
3294 2004 None 111 Human Binding pAC50 = 5.0 5.0 -323 45
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
71360 2004 None 111 Human Binding pAC50 = 5.0 5.0 -323 45
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
87 2004 None 111 Human Binding pAC50 = 5.0 5.0 -323 45
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
CHEMBL14376 2004 None 111 Human Binding pAC50 = 5.0 5.0 -323 45
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
DB04946 2004 None 111 Human Binding pAC50 = 5.0 5.0 -323 45
Binding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human CCKBR in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C 10.1038/s41467-023-40064-9
4627 821 None 50 Human Binding pEC50 = 10.3 10.3 -1 5
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
864 821 None 50 Human Binding pEC50 = 10.3 10.3 -1 5
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
9833444 821 None 50 Human Binding pEC50 = 10.3 10.3 -1 5
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
CHEMBL1121 821 None 50 Human Binding pEC50 = 10.3 10.3 -1 5
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
DB09142 821 None 50 Human Binding pEC50 = 10.3 10.3 -1 5
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00017a022
4627 821 None 50 Human Binding pEC50 = 10.0 10.0 -1 5
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
864 821 None 50 Human Binding pEC50 = 10.0 10.0 -1 5
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
9833444 821 None 50 Human Binding pEC50 = 10.0 10.0 -1 5
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL1121 821 None 50 Human Binding pEC50 = 10.0 10.0 -1 5
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
DB09142 821 None 50 Human Binding pEC50 = 10.0 10.0 -1 5
Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cellsDisplacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL413654 213077 None 0 Rat Binding pEC50 = 6 6.0 2 2
Tested for the 50% inhibition level against [125I]- gastrin binding in AR42J cellsTested for the 50% inhibition level against [125I]- gastrin binding in AR42J cells
ChEMBL None None None CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
10260074 106621 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 875 25 7 10 3.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
CHEMBL3143010 106621 None 0 Human Binding pEC50 = 6.9 6.9 - 0
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 875 25 7 10 3.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
162661486 181461 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5678 175 68 78 -9.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CSC2CC(=O)N(CCC(=O)NC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CCCCNC(=O)CCN3C(=O)CC(SC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc4c[nH]cn4)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C3=O)C2=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4764500 181461 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5678 175 68 78 -9.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CSC2CC(=O)N(CCC(=O)NC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)CCCCNC(=O)CCN3C(=O)CC(SC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc4c[nH]cn4)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1)C3=O)C2=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
162661520 181527 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5663 173 67 77 -8.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)CSC2CC(=O)N(CCC(=O)NCCCCC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)CCN3C(=O)CC(SC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)NCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(=O)O)NC1=O)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
CHEMBL4765166 181527 None 0 Human Binding pEC50 = 7.8 7.8 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5663 173 67 77 -8.6 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)CSC2CC(=O)N(CCC(=O)NCCCCC(C(=O)NCCCCCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)CCN3C(=O)CC(SC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)NCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(=O)O)NC1=O)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
10032955 168033 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL432256 168033 None 0 Human Binding pEC50 = 5.6 5.6 - 0
Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL319438 211215 None 0 Human Binding pEC50 = 6.3 6.3 - 0
Compound was evaluated for the [Ca2+] mobilization in stably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptorCompound was evaluated for the [Ca2+] mobilization in stably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00017a022
162668747 182617 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6123 176 72 84 -13.9 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)[C@@H](C)CC)[C@@H](C)CC)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
CHEMBL4788440 182617 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6123 176 72 84 -13.9 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)[C@@H](C)CC)[C@@H](C)CC)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
162662538 182022 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5436 173 70 79 -19.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4780789 182022 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5436 173 70 79 -19.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
162665647 182361 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5421 171 69 78 -18.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
CHEMBL4784851 182361 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5421 171 69 78 -18.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
162665440 182258 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5338 170 70 76 -18.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4783736 182258 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5338 170 70 76 -18.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
162673451 183187 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6108 174 71 83 -13.0 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
CHEMBL4795718 183187 None 0 Human Binding pEC50 = 8.1 8.1 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 6108 174 71 83 -13.0 CCCCCCCCCCCCCCCC(=O)NCCCCCCNC(=O)C1CCCCNC(=O)CCN2C(=O)CC(SC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3c[nH]cn3)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N3CCC[C@H]3C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)CSC3CC(=O)N(CCC(=O)N1)C3=O)C2=O 10.1021/acs.jmedchem.0c00736
90663239 106622 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 946 27 8 11 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
CHEMBL3143011 106622 None 0 Human Binding pEC50 = 7.1 7.1 - 0
Tested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glandsTested for the 50% inhibition level against [125I]- gastrin binding to guinea pig gastric glands
ChEMBL 946 27 8 11 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)CCC(=O)N(Cc1ccccc1)N=NCCCl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
162677145 183467 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5323 168 69 75 -17.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
CHEMBL4799182 183467 None 0 Human Binding pEC50 = 8.0 8.0 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 5323 168 69 75 -17.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00736
86291008 179550 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 4364 151 59 60 -13.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
CHEMBL4741697 179550 None 0 Human Binding pEC50 = 8 8.0 - 0
Agonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 minsAgonist activity at human CCK-2R expressed in HEK293 cells assessed as stimulation of ERK phosphorylation incubated for 5 mins
ChEMBL 4364 151 59 60 -13.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c00736
44348922 16239 None 0 Bovine Binding pIC50 = 10.5 10.5 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 992 25 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL122438 16239 None 0 Bovine Binding pIC50 = 10.5 10.5 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 992 25 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC1CCC[C@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
880 2237 None 5 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 3 7 3.5 O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C 10.1021/jm9506736
9935175 2237 None 5 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 3 7 3.5 O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C 10.1021/jm9506736
CHEMBL2093059 2237 None 5 Human Binding pIC50 = 10.3 10.3 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 3 7 3.5 O=C(N[C@@H]1N=C(C2CCCCC2)c2c(N(C1=O)C)cccc2)Nc1cccc(c1)N(c1n[nH]nn1)C 10.1021/jm9506736
10051431 121124 None 0 Rat Binding pIC50 = 10.2 10.2 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL357502 121124 None 0 Rat Binding pIC50 = 10.2 10.2 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
10480605 78358 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 4 7 3.7 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
CHEMBL2110201 78358 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 5 4 7 3.7 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
9916170 76551 None 3 Mouse Binding pIC50 = 10.1 10.1 - 0
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 575 10 4 4 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 10.1016/s0960-894x(00)00198-0
CHEMBL2062146 76551 None 3 Mouse Binding pIC50 = 10.1 10.1 - 0
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 575 10 4 4 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccc(F)cc1 10.1016/s0960-894x(00)00198-0
44348850 17946 None 0 Bovine Binding pIC50 = 10.1 10.1 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL126008 17946 None 0 Bovine Binding pIC50 = 10.1 10.1 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
9960703 168036 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 621 6 3 7 4.0 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
CHEMBL432266 168036 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 621 6 3 7 4.0 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2ccccc2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
9872735 187025 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 567 5 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL49085 187025 None 0 Human Binding pIC50 = 10.1 10.1 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 567 5 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3ccccc3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
155559320 174862 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4563364 174862 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1872 72 18 23 3.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
21842340 44088 None 0 Rat Binding pIC50 = 10 10.0 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL151483 44088 None 0 Rat Binding pIC50 = 10 10.0 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
132980 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm00032a002
881 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm00032a002
CHEMBL420783 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm00032a002
9828961 167984 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL431919 167984 None 0 Human Binding pIC50 = 10 10.0 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
132980 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1016/0960-894X(95)00530-0
881 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1016/0960-894X(95)00530-0
CHEMBL420783 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1016/0960-894X(95)00530-0
21842392 166706 None 21 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 498 6 3 6 4.1 CNc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1039/C7MD00171A
CHEMBL4282712 166706 None 21 Human Binding pIC50 = 10 10.0 - 0
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 498 6 3 6 4.1 CNc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1039/C7MD00171A
132980 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm9608523
881 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm9608523
CHEMBL420783 2238 None 12 Human Binding pIC50 = 10 10.0 - 1
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 445 2 2 4 4.0 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(N2CC3CCC(C2)CC3)c2c(N(C1=O)C)cccc2 10.1021/jm9608523
887 4108 None 33 Rat Binding pIC50 = 10 10.0 1 4
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
9870520 4108 None 33 Rat Binding pIC50 = 10 10.0 1 4
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
CHEMBL324547 4108 None 33 Rat Binding pIC50 = 10 10.0 1 4
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
DB12355 4108 None 33 Rat Binding pIC50 = 10 10.0 1 4
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm960669+
122130 4113 None 39 Rat Binding pIC50 = 10.0 10.0 - 1
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1016/0960-894X(95)00556-9
888 4113 None 39 Rat Binding pIC50 = 10.0 10.0 - 1
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1016/0960-894X(95)00556-9
CHEMBL115121 4113 None 39 Rat Binding pIC50 = 10.0 10.0 - 1
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1016/0960-894X(95)00556-9
3452843 119523 None 15 Rat Binding pIC50 = 10.0 10.0 - 10
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 516 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL345686 119523 None 15 Rat Binding pIC50 = 10.0 10.0 - 10
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 516 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
10323431 57750 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 493 4 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL166941 57750 None 0 Human Binding pIC50 = 10.0 10.0 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 493 4 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)N(c2nn[nH]n2)CC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
122130 4113 None 39 Rat Binding pIC50 = 10.0 10.0 - 1
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1021/jm960669+
888 4113 None 39 Rat Binding pIC50 = 10.0 10.0 - 1
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1021/jm960669+
CHEMBL115121 4113 None 39 Rat Binding pIC50 = 10.0 10.0 - 1
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 516 6 2 4 5.5 Cc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)CC(=O)c1ccccc1C)cccc2 10.1021/jm960669+
24039375 9885 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 540 8 2 6 4.9 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL114277 9885 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 540 8 2 6 4.9 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
9850184 110869 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 538 6 2 6 4.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
CHEMBL326102 110869 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 538 6 2 6 4.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
23844129 113497 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 497 6 3 5 4.7 CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL332024 113497 None 0 Rat Binding pIC50 = 10.0 10.0 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 497 6 3 5 4.7 CNc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
21842325 120120 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL351144 120120 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
4627 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
864 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
9833444 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
DB09142 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cellsDisplacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells
ChEMBL None None None None 10.1016/j.bmc.2016.03.006
4627 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
864 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
9833444 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
DB09142 821 None 50 Human Binding pIC50 = 9.9 9.9 -1 5
Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
10006792 44923 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL152306 44923 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
155543846 173210 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4522865 173210 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 2.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155546692 173640 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4534236 173640 None 0 Human Binding pIC50 = 9.9 9.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1861 72 19 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
108187 925 None 37 Human Binding pIC50 = 9.9 9.9 -4 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
873 925 None 37 Human Binding pIC50 = 9.9 9.9 -4 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
CHEMBL2062154 925 None 37 Human Binding pIC50 = 9.9 9.9 -4 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
CHEMBL287735 925 None 37 Human Binding pIC50 = 9.9 9.9 -4 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00017a022
23757281 9849 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 539 8 2 5 5.5 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL114072 9849 None 0 Rat Binding pIC50 = 9.9 9.9 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 539 8 2 5 5.5 CCN(CC)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
44376113 119959 None 0 Human Binding pIC50 = 9.9 9.9 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL349730 119959 None 0 Human Binding pIC50 = 9.9 9.9 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
903 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
9850711 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
CHEMBL138534 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
CHEMBL2111312 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80273-5
903 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
9850711 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
CHEMBL138534 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
CHEMBL2111312 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm000937a
904 3024 None 10 Mouse Binding pIC50 = 9.8 9.8 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
9915756 3024 None 10 Mouse Binding pIC50 = 9.8 9.8 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL2111204 3024 None 10 Mouse Binding pIC50 = 9.8 9.8 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL356898 3024 None 10 Mouse Binding pIC50 = 9.8 9.8 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
903 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
9850711 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL138534 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL2111312 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
903 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
9850711 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
CHEMBL138534 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
CHEMBL2111312 3022 None 9 Mouse Binding pIC50 = 9.8 9.8 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm970065l
155558199 174767 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4561184 174767 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1894 75 19 24 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155533399 171843 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4468861 171843 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1838 72 19 24 1.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10744359 10155 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 513 6 2 6 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL115833 10155 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 513 6 2 6 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
155544674 174934 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4565336 174934 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
15291593 112850 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 537 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL330933 112850 None 0 Rat Binding pIC50 = 9.8 9.8 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 537 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCC3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
9828961 167984 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL431919 167984 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 548 6 4 4 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
11798691 58269 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 473 5 4 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
CHEMBL168263 58269 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 473 5 4 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
CHEMBL384035 212314 None 4 Human Binding pIC50 = 9.7 9.7 8 4
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
CHEMBL428666 212314 None 4 Human Binding pIC50 = 9.7 9.7 8 4
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
10839478 110655 None 1 Rat Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL325863 110655 None 1 Rat Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
145993882 167334 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)c1 10.1039/C7MD00171A
CHEMBL4294388 167334 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Br)cc2)c1 10.1039/C7MD00171A
155516677 170087 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4443415 170087 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 18 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44368611 121992 None 0 Mouse Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 541 10 4 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL359292 121992 None 0 Mouse Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 541 10 4 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
23928173 114146 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 6 2 5 4.7 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL332931 114146 None 0 Rat Binding pIC50 = 9.7 9.7 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 6 2 5 4.7 CN(C)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL382409 212304 None 0 Human Binding pIC50 = 9.7 9.7 6918 2
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44300743 100958 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 572 6 4 6 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL294161 100958 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 572 6 4 6 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
10459108 28407 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 8 2 5 3.9 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137516 28407 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 8 2 5 3.9 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
4627 821 None 50 Human Binding pIC50 = 9.6 9.6 -1 5
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
864 821 None 50 Human Binding pIC50 = 9.6 9.6 -1 5
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
9833444 821 None 50 Human Binding pIC50 = 9.6 9.6 -1 5
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.6 9.6 -1 5
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
DB09142 821 None 50 Human Binding pIC50 = 9.6 9.6 -1 5
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL None None None None 10.1021/jm960249k
21842375 44268 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL151719 44268 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
21842375 44268 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL151719 44268 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
44313549 204840 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(S(=O)(=O)NC(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL75490 204840 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(S(=O)(=O)NC(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
10440992 161294 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 28 9 11 1.8 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL412238 161294 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 28 9 11 1.8 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10075097 28642 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 511 6 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm00078a018
CHEMBL137726 28642 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 511 6 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm00078a018
44331825 167971 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 692 5 1 6 5.1 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL431805 167971 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 692 5 1 6 5.1 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
44300989 100978 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 625 7 4 6 4.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL294252 100978 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 625 7 4 6 4.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2C1CCCCC1 10.1016/0960-894X(95)00327-P
136055865 120194 None 0 Human Binding pIC50 = 9.6 9.6 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL351891 120194 None 0 Human Binding pIC50 = 9.6 9.6 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
10257790 102853 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 587 6 3 6 4.6 Cc1ccccc1S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL305649 102853 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 587 6 3 6 4.6 Cc1ccccc1S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
21842331 43536 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 7 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL150869 43536 None 0 Rat Binding pIC50 = 9.6 9.6 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 7 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)CC3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
10414170 170616 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL445095 170616 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
9953071 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL58699 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
9953071 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL58699 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
10414170 170616 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
CHEMBL445095 170616 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
9953071 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL58699 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
10719765 78359 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 6 4 7 3.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
CHEMBL2110202 78359 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 487 6 4 7 3.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm9506736
9953071 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL58699 199063 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
155555346 174370 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4551834 174370 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL384035 212314 None 4 Human Binding pIC50 = 9.5 9.5 8 4
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL428666 212314 None 4 Human Binding pIC50 = 9.5 9.5 8 4
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL384035 212314 None 4 Human Binding pIC50 = 9.5 9.5 8 4
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
CHEMBL428666 212314 None 4 Human Binding pIC50 = 9.5 9.5 8 4
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
4627 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
864 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
9833444 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
CHEMBL1121 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
DB09142 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL None None None None 10.1016/s0960-894x(00)00198-0
18957789 204844 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL75536 204844 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
71460027 79713 None 0 Mouse Binding pIC50 = 9.5 9.5 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL2115544 79713 None 0 Mouse Binding pIC50 = 9.5 9.5 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL269098 210776 None 0 Mouse Binding pIC50 = 9.5 9.5 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(01)81250-6
4627 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
864 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
9833444 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
CHEMBL1121 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
DB09142 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00092a007
15667003 97337 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 1016 27 8 11 2.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL269355 97337 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 1016 27 8 11 2.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(CCC)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
4627 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
864 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
9833444 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
CHEMBL1121 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
DB09142 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm00105a062
10673039 58262 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 501 5 3 7 3.8 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
CHEMBL168253 58262 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 501 5 3 7 3.8 Cc1ccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
4627 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
864 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
9833444 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
CHEMBL1121 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
DB09142 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None None 10.1016/S0960-894X(00)80687-3
4627 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
864 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
9833444 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
CHEMBL1121 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
DB09142 821 None 50 Mouse Binding pIC50 = 9.5 9.5 - 5
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None None 10.1021/jm00057a005
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9601664
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm950626d
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None None 10.1021/jm00001a027
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None None 10.1021/jm00017a022
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(97)00062-0
10074366 120596 None 0 Mouse Binding pIC50 = 9.5 9.5 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 120596 None 0 Mouse Binding pIC50 = 9.5 9.5 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 120596 None 0 Mouse Binding pIC50 = 9.5 9.5 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm960205b
4627 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
864 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
9833444 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
DB09142 821 None 50 Human Binding pIC50 = 9.5 9.5 -1 5
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL None None None None 10.1021/jm970265x
44210536 169359 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 3.0 CC(=O)NS(=O)(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL441989 169359 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 3.0 CC(=O)NS(=O)(=O)c1cccc(NC(=O)NC2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
44293892 161685 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 613 6 2 5 5.8 CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL413267 161685 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 613 6 2 5 5.8 CSc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
9892971 120995 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL356386 120995 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
10484212 99877 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL285921 99877 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
155564367 175154 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4570130 175154 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 18 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
21842313 168553 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL435639 168553 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 508 6 2 4 5.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
162659624 181234 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1449 38 15 19 -1.6 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4761587 181234 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1449 38 15 19 -1.6 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
21842373 120978 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL356226 120978 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3(C)CC3)C2=O)c1 10.1016/0960-894X(95)00556-9
23844130 10112 None 16 Rat Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 484 5 3 6 3.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
CHEMBL115612 10112 None 16 Rat Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 484 5 3 6 3.6 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
9982757 51469 None 1 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL158235 51469 None 1 Rat Binding pIC50 = 9.4 9.4 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
9891461 165020 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL422604 165020 None 0 Rat Binding pIC50 = 9.4 9.4 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 2 5 4.3 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL37830 212258 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44293810 101751 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 581 5 2 4 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL299800 101751 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 581 5 2 4 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
10369805 100550 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL291458 100550 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
10369805 100550 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL291458 100550 None 0 Human Binding pIC50 = 9.3 9.3 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
44348650 113104 None 0 Bovine Binding pIC50 = 9.3 9.3 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL331408 113104 None 0 Bovine Binding pIC50 = 9.3 9.3 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 986 24 11 11 2.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10414170 170616 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL445095 170616 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
10414170 170616 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
CHEMBL445095 170616 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00121a004
15666988 107257 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL316949 107257 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14888718 77250 None 0 Bovine Binding pIC50 = 9.3 9.3 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079606 77250 None 0 Bovine Binding pIC50 = 9.3 9.3 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
23815458 167793 None 1 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL430516 167793 None 1 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 483 5 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
903 3022 None 9 Mouse Binding pIC50 = 9.3 9.3 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
9850711 3022 None 9 Mouse Binding pIC50 = 9.3 9.3 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL138534 3022 None 9 Mouse Binding pIC50 = 9.3 9.3 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL2111312 3022 None 9 Mouse Binding pIC50 = 9.3 9.3 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
21842317 121678 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL358646 121678 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
21842317 121678 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL358646 121678 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
10322988 10146 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL115772 10146 None 0 Rat Binding pIC50 = 9.3 9.3 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 482 5 2 4 4.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
10478703 119910 None 1 Human Binding pIC50 = 9.3 9.3 - 1
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL349291 119910 None 1 Human Binding pIC50 = 9.3 9.3 - 1
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10323637 106184 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm00078a018
CHEMBL313813 106184 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm00078a018
10323637 106184 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm9608523
CHEMBL313813 106184 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 498 7 2 5 3.6 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm9608523
21842400 120972 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 7 2 4 5.3 CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
CHEMBL356191 120972 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 7 2 4 5.3 CCC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
9806412 204891 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 2.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL75892 204891 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 511 5 3 6 2.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
10814625 83465 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL22003 83465 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 3 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(N(C)c3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
155540415 172937 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516868 172937 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1862 71 17 23 3.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
18957759 103015 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL306944 103015 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
15667014 107256 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL316944 107256 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10673307 110634 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 7 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL325746 110634 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 511 7 3 5 4.2 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(NC=O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
44300745 198349 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 562 6 3 5 5.3 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL57643 198349 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 562 6 3 5 5.3 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](C3CCCCC3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL1806526 208970 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
162657745 181014 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4759105 181014 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
9984739 114812 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 538 5 3 3 6.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 10.1021/jm00048a015
CHEMBL334100 114812 None 0 Human Binding pIC50 = 9.2 9.2 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 538 5 3 3 6.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C1CCCCC1 10.1021/jm00048a015
10369336 116753 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337574 116753 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10480792 45798 None 0 Mouse Binding pIC50 = 9.2 9.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153095 45798 None 0 Mouse Binding pIC50 = 9.2 9.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3350686 45798 None 0 Mouse Binding pIC50 = 9.2 9.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10009526 110501 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranes
ChEMBL 655 6 3 7 4.6 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
CHEMBL32492 110501 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptor Cholecystokinin type B receptor cerebral cortical membranes
ChEMBL 655 6 3 7 4.6 O=C(Nc1cccc(-c2nn[nH]n2)c1)NC1N=C(c2ccccc2F)c2cccc(Cl)c2N(CC(=O)N2CC3CCC(CC3)C2)C1=O 10.1016/s0960-894x(98)00237-6
145992870 166886 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 475 7 4 7 3.8 CCOc1ccc(-n2c(NNC(=S)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4286087 166886 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 475 7 4 7 3.8 CCOc1ccc(-n2c(NNC(=S)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
10484212 99877 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
CHEMBL285921 99877 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
10484212 99877 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL285921 99877 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
44301015 199059 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 609 7 5 7 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL58658 199059 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 609 7 5 7 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)Nc3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL1806772 208976 None 0 Human Binding pIC50 = 9.2 9.2 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
6439414 3023 None 14 Mouse Binding pIC50 = 9.2 9.2 2454 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
867 3023 None 14 Mouse Binding pIC50 = 9.2 9.2 2454 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
CHEMBL3351022 3023 None 14 Mouse Binding pIC50 = 9.2 9.2 2454 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
CHEMBL341460 3023 None 14 Mouse Binding pIC50 = 9.2 9.2 2454 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00105a062
44368728 119504 None 0 Mouse Binding pIC50 = 9.2 9.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 596 11 5 4 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL345512 119504 None 0 Mouse Binding pIC50 = 9.2 9.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 596 11 5 4 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL2370335 209828 None 0 Rat Binding pIC50 = 9.2 9.2 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CCC[C@@H]1CCN(C(=O)[C@@H]2Cc3c[nH]c4cccc(c34)CC(=O)N2)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(96)00546-X
18656023 104880 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL311154 104880 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 573 6 3 6 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NS(=O)(=O)c3ccccc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
18656022 204796 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL75019 204796 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 539 6 3 6 3.6 CC(C)S(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00399-E
CHEMBL407057 212633 None 0 Human Binding pIC50 = 9.1 9.1 120 4
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm960078j
44369595 168525 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 475 7 2 7 4.2 Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL435447 168525 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 475 7 2 7 4.2 Cc1cccc(NCNC2N=C(c3nccs3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL1806527 208971 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
9853654 22787 None 41 Mouse Binding pIC50 = 9.1 9.1 -31 2
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00092a007
CHEMBL1328 22787 None 41 Mouse Binding pIC50 = 9.1 9.1 -31 2
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00092a007
14802543 170477 None 0 Mouse Binding pIC50 = 9.1 9.1 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 600 11 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112693 170477 None 0 Mouse Binding pIC50 = 9.1 9.1 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 600 11 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL444902 170477 None 0 Mouse Binding pIC50 = 9.1 9.1 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 600 11 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CC(=O)O)c1ccccc1 10.1021/jm00105a062
9853654 22787 None 41 Mouse Binding pIC50 = 9.1 9.1 -31 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a062
CHEMBL1328 22787 None 41 Mouse Binding pIC50 = 9.1 9.1 -31 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a062
14802525 116725 None 1 Mouse Binding pIC50 = 9.1 9.1 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL337384 116725 None 1 Mouse Binding pIC50 = 9.1 9.1 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00105a062
10392653 119039 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1021/jm00078a018
CHEMBL342640 119039 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1021/jm00078a018
9853654 22787 None 41 Mouse Binding pIC50 = 9.1 9.1 -31 2
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00057a005
CHEMBL1328 22787 None 41 Mouse Binding pIC50 = 9.1 9.1 -31 2
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00057a005
44368613 121000 None 0 Mouse Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 610 12 5 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL356419 121000 None 0 Mouse Binding pIC50 = 9.1 9.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 610 12 5 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
44300852 101969 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 566 6 4 6 4.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL301418 101969 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 566 6 4 6 4.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
10009450 99864 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 649 7 3 7 4.5 CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
CHEMBL285850 99864 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesCompound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranes
ChEMBL 649 7 3 7 4.5 CCc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/s0960-894x(98)00237-6
44293998 188422 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 609 6 2 5 5.3 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL50215 188422 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 609 6 2 5 5.3 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
22883501 10419 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 552 6 2 6 5.0 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
CHEMBL116300 10419 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 552 6 2 6 5.0 CC(C)(C)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(N3CCCCC3)c2)N=C(c2ccccn2)c2ccccc21 10.1021/jm960669+
21842353 121030 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 550 7 2 4 6.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL356631 121030 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 550 7 2 4 6.5 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C3CCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
44300863 198347 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 619 7 4 6 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL57642 198347 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 619 7 4 6 3.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(C)(=O)=O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
44300891 199552 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 586 7 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 10.1016/0960-894X(95)00327-P
CHEMBL59234 199552 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 586 7 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2CC1CCCCC1 10.1016/0960-894X(95)00327-P
15281185 49452 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 484 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL156484 49452 None 0 Rat Binding pIC50 = 9.1 9.1 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 484 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3cnccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
155524181 170851 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4453982 170851 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 71 18 22 2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL1807151 208977 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CO)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
162673067 183141 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1403 38 16 20 -3.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL4795198 183141 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1403 38 16 20 -3.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL2310858 209488 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CCCC1CCN([C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc2ccccc2)C(N)=O)[C@H]1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1 10.1021/jm00094a001
44348901 141826 None 0 Bovine Binding pIC50 = 9.0 9.0 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL386376 141826 None 0 Bovine Binding pIC50 = 9.0 9.0 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)c1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
4627 821 None 50 Human Binding pIC50 = 9.0 9.0 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
864 821 None 50 Human Binding pIC50 = 9.0 9.0 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
9833444 821 None 50 Human Binding pIC50 = 9.0 9.0 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
CHEMBL1121 821 None 50 Human Binding pIC50 = 9.0 9.0 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
DB09142 821 None 50 Human Binding pIC50 = 9.0 9.0 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
10031259 4297 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 586 12 3 4 4.3 O=C(Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL100799 4297 None 0 Rat Binding pIC50 = 9.0 9.0 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 586 12 3 4 4.3 O=C(Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
44396655 122048 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 122048 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44293971 189031 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 611 6 3 5 4.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL50926 189031 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 611 6 3 5 4.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(C(=O)O)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
44300889 100759 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 6 4 6 3.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C 10.1016/0960-894X(95)00327-P
CHEMBL292856 100759 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 532 6 4 6 3.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2C(C)C 10.1016/0960-894X(95)00327-P
10744557 32724 None 0 Mouse Binding pIC50 = 9 9.0 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O 10.1021/jm970065l
CHEMBL141370 32724 None 0 Mouse Binding pIC50 = 9 9.0 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C(=O)O 10.1021/jm970065l
10435698 141406 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL38404 141406 None 0 Human Binding pIC50 = 9 9.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
44301037 100855 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 633 8 4 6 4.0 CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL293490 100855 None 0 Human Binding pIC50 = 9 9.0 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 633 8 4 6 4.0 CCS(=O)(=O)NC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
10814373 207101 None 0 Mouse Binding pIC50 = 9 9.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 474 7 3 8 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9203 207101 None 0 Mouse Binding pIC50 = 9 9.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 474 7 3 8 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc([N+](=O)[O-])c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10435698 141406 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL38404 141406 None 0 Human Binding pIC50 = 9 9.0 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
9853654 22787 None 41 Human Binding pIC50 = 9 9.0 31 2
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
CHEMBL1328 22787 None 41 Human Binding pIC50 = 9 9.0 31 2
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.0c01233
10369805 100550 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL291458 100550 None 0 Human Binding pIC50 = 9 9.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
44293999 188423 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 597 6 2 5 5.1 COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL50216 188423 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 597 6 2 5 5.1 COc1cccc(NC(=O)NC2N=C(c3ccccc3F)c3cccc(C)c3N(CC(=O)N3CC4CCC(CC4)C3)C2=O)c1 10.1016/S0960-894X(96)00609-9
10074702 27612 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 500 8 2 6 4.0 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136966 27612 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 500 8 2 6 4.0 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10435698 141406 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL38404 141406 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
4627 821 None 50 Rat Binding pIC50 = 9 9.0 1 5
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
864 821 None 50 Rat Binding pIC50 = 9 9.0 1 5
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
9833444 821 None 50 Rat Binding pIC50 = 9 9.0 1 5
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
CHEMBL1121 821 None 50 Rat Binding pIC50 = 9 9.0 1 5
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
DB09142 821 None 50 Rat Binding pIC50 = 9 9.0 1 5
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL None None None None 10.1021/jm00079a003
44376112 120191 None 0 Human Binding pIC50 = 9.0 9.0 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL351854 120191 None 0 Human Binding pIC50 = 9.0 9.0 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
10007047 16921 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
CHEMBL125253 16921 None 0 Human Binding pIC50 = 9.0 9.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
CHEMBL218327 209392 None 0 Human Binding pIC50 = 9.0 9.0 -2 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
5311201 207393 None 35 Human Binding pIC50 = 9.0 9.0 -27 6
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL9387 207393 None 35 Human Binding pIC50 = 9.0 9.0 -27 6
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
15667019 208227 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 905 26 9 10 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98631 208227 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 905 26 9 10 2.0 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10576729 59228 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 4 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
CHEMBL170275 59228 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 5 4 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1Nc1nn[nH]n1 10.1021/jm9506736
5311201 207393 None 35 Human Binding pIC50 = 9.0 9.0 -27 6
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00164a020
CHEMBL9387 207393 None 35 Human Binding pIC50 = 9.0 9.0 -27 6
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00164a020
10789887 207425 None 0 Mouse Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 454 6 3 7 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9405 207425 None 0 Mouse Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 454 6 3 7 4.2 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10075014 162979 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL417521 162979 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
10075014 162979 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
CHEMBL417521 162979 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
44368562 121961 None 0 Mouse Binding pIC50 = 8.9 8.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL359076 121961 None 0 Mouse Binding pIC50 = 8.9 8.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
10696336 205333 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 487 5 3 4 4.6 CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL79565 205333 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 487 5 3 4 4.6 CCCN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
10364786 104869 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL311061 104869 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10768084 10017 None 1 Rat Binding pIC50 = 8.9 8.9 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
CHEMBL114991 10017 None 1 Rat Binding pIC50 = 8.9 8.9 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 2 6 4.1 CN(C)c1cccc(NC(=O)N[C@H]2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm960669+
10815039 112845 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 493 5 2 5 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL330917 112845 None 0 Rat Binding pIC50 = 8.9 8.9 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 493 5 2 5 4.5 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
162658676 180980 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4758706 180980 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1489 37 14 19 -0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
71450869 84382 None 0 Mouse Binding pIC50 = 8.9 8.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 5 6 4.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL2112338 84382 None 0 Mouse Binding pIC50 = 8.9 8.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 5 6 4.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL2219559 84382 None 0 Mouse Binding pIC50 = 8.9 8.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 5 6 4.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCS(=O)(=O)O)c1ccccc1 10.1021/jm00092a007
4627 821 None 50 Mouse Binding pIC50 = 8.9 8.9 - 5
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
864 821 None 50 Mouse Binding pIC50 = 8.9 8.9 - 5
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
9833444 821 None 50 Mouse Binding pIC50 = 8.9 8.9 - 5
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
CHEMBL1121 821 None 50 Mouse Binding pIC50 = 8.9 8.9 - 5
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
DB09142 821 None 50 Mouse Binding pIC50 = 8.9 8.9 - 5
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL None None None None 10.1016/s0960-894x(01)00044-0
10364786 104869 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL311061 104869 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)NC2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
10251516 13371 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL1192472 13371 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL543712 13371 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
44301034 101585 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 556 6 3 5 4.8 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL298627 101585 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 556 6 3 5 4.8 COC(=O)c1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccc(C)cc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00327-P
44210535 102997 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 434 4 3 4 3.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
CHEMBL306803 102997 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Binding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranesBinding affinity towards Cholecystokinin type B receptor was measured by displacement of [125I]CCK from guinea pig cortical membranes
ChEMBL 434 4 3 4 3.9 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/0960-894X(95)00399-E
162673242 183206 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
CHEMBL4795913 183206 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysisDisplacement of [125I][3-iodo Tyr12,Leu15]gastrin-I from human CCK2R expressed in human A431 cells measured after 1 hr by gamma counter analysis
ChEMBL 1475 37 14 19 -1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1 10.1021/acs.jmedchem.0c01233
15667012 169048 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL439591 169048 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 28 10 11 1.5 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10482588 18540 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2Cc1ccccc1 10.1021/jm00048a015
CHEMBL127521 18540 None 0 Human Binding pIC50 = 8.9 8.9 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.8 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2Cc1ccccc1 10.1021/jm00048a015
10436569 77843 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL2092976 77843 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
10791546 207081 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL9188 207081 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
10346998 18108 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 2 3 5.7 CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C 10.1021/jm00048a015
CHEMBL126865 18108 None 0 Human Binding pIC50 = 8.8 8.8 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 2 3 5.7 CN(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)C(C)(C)C 10.1021/jm00048a015
10837729 106443 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 461 5 3 4 4.5 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL313983 106443 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 461 5 3 4 4.5 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL206974 209180 None 0 Human Binding pIC50 = 8.8 8.8 1 5
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
21842365 119752 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL347843 119752 None 0 Rat Binding pIC50 = 8.8 8.8 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
4627 821 None 50 Human Binding pIC50 = 8.8 8.8 -1 5
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
864 821 None 50 Human Binding pIC50 = 8.8 8.8 -1 5
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
9833444 821 None 50 Human Binding pIC50 = 8.8 8.8 -1 5
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
CHEMBL1121 821 None 50 Human Binding pIC50 = 8.8 8.8 -1 5
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
DB09142 821 None 50 Human Binding pIC50 = 8.8 8.8 -1 5
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80680-0
CHEMBL1806530 208973 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
10414170 170616 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL445095 170616 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL382349 212300 None 0 Human Binding pIC50 = 8.8 8.8 1 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
52949124 875 None 4 Human Binding pIC50 = 8.8 8.8 2 2
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pIC50 = 8.8 8.8 2 2
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pIC50 = 8.8 8.8 2 2
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pIC50 = 8.8 8.8 2 2
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44300890 101888 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 7 4 6 4.3 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL300776 101888 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 7 4 6 4.3 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(-c3nn[nH]n3)c1)C[C@@H]2Cc1ccccc1 10.1016/0960-894X(95)00327-P
108187 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
873 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
CHEMBL2062154 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
CHEMBL287735 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80273-5
155534566 171973 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc([C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4470833 171973 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc([C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
59923871 73958 None 1 Mouse Binding pIC50 = 8.8 8.8 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80156-0
CHEMBL2021374 73958 None 1 Mouse Binding pIC50 = 8.8 8.8 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1.3-2.7
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCC(NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80156-0
71452691 78627 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 5 7 3.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112336 78627 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 5 7 3.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)C[S+]([O-])c1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
14802538 96687 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL263969 96687 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00092a007
108187 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
873 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
CHEMBL2062154 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
CHEMBL287735 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00105a062
14802537 85986 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL2304062 85986 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
108187 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
873 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
CHEMBL2062154 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
CHEMBL287735 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80685-X
14802538 96687 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL263969 96687 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/s0960-894x(98)00677-5
108187 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
873 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
CHEMBL2062154 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
CHEMBL287735 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(97)00356-9
44368727 119503 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 598 12 5 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL345511 119503 None 0 Mouse Binding pIC50 = 8.8 8.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 598 12 5 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
108187 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
873 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
CHEMBL2062154 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
CHEMBL287735 925 None 37 Mouse Binding pIC50 = 8.8 8.8 -9 5
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970065l
14802539 76550 None 1 Mouse Binding pIC50 = 8.8 8.8 - 1
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2062144 76550 None 1 Mouse Binding pIC50 = 8.8 8.8 - 1
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 1.3-3.7
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL35471 211731 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44293812 101713 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 645 5 2 4 5.9 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL299523 101713 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 645 5 2 4 5.9 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Br)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
44348651 168235 None 0 Bovine Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 952 26 11 11 0.6 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL433647 168235 None 0 Bovine Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 952 26 11 11 0.6 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
9866980 4654 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 423 3 2 4 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 10.1016/0960-894X(95)00530-0
CHEMBL103119 4654 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 423 3 2 4 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N3C[C@H](C)N=C23)c1 10.1016/0960-894X(95)00530-0
155553502 174173 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4547294 174173 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 72 19 22 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(=O)(O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
21842326 121289 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 8 2 4 5.3 CCC(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
CHEMBL358000 121289 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 496 8 2 4 5.3 CCC(CC)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00556-9
9936789 206587 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 529 7 3 8 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL8890 206587 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 529 7 3 8 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)OC(C)(C)C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44303664 100707 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 661 16 7 7 0.3 CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 10.1016/S0960-894X(01)81005-2
CHEMBL292493 100707 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 661 16 7 7 0.3 CCCC1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN)C1 10.1016/S0960-894X(01)81005-2
CHEMBL3143186 211137 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CCC[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
52949124 875 None 4 Human Binding pIC50 = 8.7 8.7 2 2
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pIC50 = 8.7 8.7 2 2
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pIC50 = 8.7 8.7 2 2
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pIC50 = 8.7 8.7 2 2
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
10623795 207282 None 0 Mouse Binding pIC50 = 8 8.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
CHEMBL9319 207282 None 0 Mouse Binding pIC50 = 8 8.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
9960432 39422 None 5 Human Binding pIC50 = 8 8.0 12 2
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
CHEMBL147186 39422 None 5 Human Binding pIC50 = 8 8.0 12 2
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
46235271 73646 None 2 Human Binding pIC50 = 8 8.0 -2 2
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pIC50 = 8 8.0 -2 2
Displacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
15667011 96655 None 1 Human Binding pIC50 = 8 8.0 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL263742 96655 None 1 Human Binding pIC50 = 8 8.0 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10102593 141503 None 2 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 141503 None 2 Human Binding pIC50 = 8 8.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
44333048 169255 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
CHEMBL441165 169255 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
44329342 108427 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 571 7 3 5 5.5 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc([N+](=O)[O-])c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL319882 108427 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 571 7 3 5 5.5 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc([N+](=O)[O-])c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
10255357 18516 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
CHEMBL127397 18516 None 0 Human Binding pIC50 = 8 8.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
10393441 171711 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 580 7 3 3 6.5 CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm00048a015
CHEMBL446682 171711 None 0 Human Binding pIC50 = 8.0 8.0 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 580 7 3 3 6.5 CC(C)(NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm00048a015
10102593 141503 None 2 Rat Binding pIC50 = 7 7.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 141503 None 2 Rat Binding pIC50 = 7 7.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
14843042 127573 None 0 Mouse Binding pIC50 = 7 7.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36634 127573 None 0 Mouse Binding pIC50 = 7 7.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
9983680 163321 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 506 7 2 5 3.8 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL418987 163321 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 506 7 2 5 3.8 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
5311148 1894 None 7 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm960249k
865 1894 None 7 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm960249k
CHEMBL293226 1894 None 7 Human Binding pIC50 = 6 6.0 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm960249k
CHEMBL3142686 211127 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44306823 203065 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 802 20 9 7 2.8 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL63707 203065 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 802 20 9 7 2.8 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
15689733 106612 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL3142905 106612 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
155515427 169947 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4441596 169947 None 0 Human Binding pIC50 = 6 6.0 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL1172246 208579 None 0 Human Binding pIC50 = 6 6.0 -1 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC1=O 10.1016/j.bmcl.2010.05.078
21121108 81997 None 2 Human Binding pIC50 = 6 6.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL216527 81997 None 2 Human Binding pIC50 = 6 6.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
5311148 1894 None 7 Human Binding pIC50 = 6 6.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm970265x
865 1894 None 7 Human Binding pIC50 = 6 6.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm970265x
CHEMBL293226 1894 None 7 Human Binding pIC50 = 6 6.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccc(cc1)N(C(=O)CN1C(=O)C(Cc2[nH]nc3c2cccc3)C(=O)N(c2c1cccc2)c1ccccc1)C(C)C 10.1021/jm970265x
14444015 106675 None 0 Human Binding pIC50 = 6 6.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
CHEMBL3143388 106675 None 0 Human Binding pIC50 = 6 6.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
44303224 141933 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 933 23 8 11 2.8 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL387073 141933 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 933 23 8 11 2.8 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349393 16832 None 0 Rat Binding pIC50 = 6 6.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 10.1021/jm00079a003
CHEMBL124764 16832 None 0 Rat Binding pIC50 = 6 6.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCCCC1 10.1021/jm00079a003
CHEMBL285051 210860 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
CHEMBL37786 212256 None 0 Human Binding pIC50 = 5 5.0 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44382805 59210 None 0 Mouse Binding pIC50 = 5 5.0 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 536 9 3 5 3.4 CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
CHEMBL170197 59210 None 0 Mouse Binding pIC50 = 5 5.0 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 536 9 3 5 3.4 CC(C)C[C@H](NC(=O)C(NC(=O)OC(C)(C)C)c1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
44306888 102328 None 0 Human Binding pIC50 = 5 5.0 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL303635 102328 None 0 Human Binding pIC50 = 5 5.0 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
44408590 161724 None 0 Human Binding pIC50 = 5 5.0 - 2
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL413644 161724 None 0 Human Binding pIC50 = 5 5.0 - 2
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
44418923 161783 None 0 Human Binding pIC50 = 5 5.0 - 2
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL414087 161783 None 0 Human Binding pIC50 = 5 5.0 - 2
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2[nH]1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44375063 55119 None 0 Mouse Binding pIC50 = 5 5.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)cc1 10.1016/s0960-894x(01)00044-0
CHEMBL161703 55119 None 0 Mouse Binding pIC50 = 5 5.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)cc1 10.1016/s0960-894x(01)00044-0
14444011 106676 None 0 Human Binding pIC50 = 5 5.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL3143393 106676 None 0 Human Binding pIC50 = 5 5.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44366341 119318 None 0 Human Binding pIC50 = 5 5.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL344125 119318 None 0 Human Binding pIC50 = 5 5.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
15104627 110476 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 462 7 2 3 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL324760 110476 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 462 7 2 3 4.7 CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
44341327 163330 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 504 13 3 2 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 10.1021/jm00116a002
CHEMBL419031 163330 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 504 13 3 2 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1 10.1021/jm00116a002
14991537 106794 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144535 106794 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14991543 106804 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 22 8 8 3.5 Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144544 106804 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 22 8 8 3.5 Cc1ccc(CCC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
14991566 168231 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 831 22 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL433636 168231 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 831 22 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10391834 38222 None 0 Human Binding pIC50 = 5 5.0 - 0
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 516 11 3 4 4.5 CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
CHEMBL146206 38222 None 0 Human Binding pIC50 = 5 5.0 - 0
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 516 11 3 4 4.5 CC(C)N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
10556460 206737 None 0 Human Binding pIC50 = 4 4.0 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL89953 206737 None 0 Human Binding pIC50 = 4 4.0 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
44306360 157873 None 0 Human Binding pIC50 = 4 4.0 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL408395 157873 None 0 Human Binding pIC50 = 4 4.0 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
10556460 206737 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL89953 206737 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 677 10 0 6 7.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(Cc4ccccc4)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
14444013 106677 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL3143394 106677 None 0 Human Binding pIC50 = 4 4.0 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44341429 110450 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 10.1021/jm00116a002
CHEMBL324652 110450 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2n1 10.1021/jm00116a002
15167797 31654 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 403 5 2 4 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 10.1021/jm00163a069
CHEMBL140495 31654 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 403 5 2 4 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)OCc1ccccc1 10.1021/jm00163a069
20190196 31786 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 388 4 1 4 3.3 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 10.1021/jm00163a069
CHEMBL140620 31786 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 388 4 1 4 3.3 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cccnc1 10.1021/jm00163a069
15614749 32243 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 393 4 2 4 3.5 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 10.1021/jm00163a069
CHEMBL140984 32243 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 393 4 2 4 3.5 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccsc1 10.1021/jm00163a069
44359880 32327 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 428 7 2 5 2.4 CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C 10.1021/jm00163a069
CHEMBL141048 32327 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 428 7 2 5 2.4 CC(=O)NCSCC(=O)NCC1CN=C(c2ccccc2F)c2ccccc2N1C 10.1021/jm00163a069
19766234 32334 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 427 4 1 3 5.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 10.1021/jm00163a069
CHEMBL141051 32334 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 427 4 1 3 5.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNc1cccc(C(F)(F)F)c1 10.1021/jm00163a069
20063245 115340 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 417 5 2 4 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 10.1021/jm00163a069
CHEMBL334933 115340 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 417 5 2 4 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)OCc1ccccc1 10.1021/jm00163a069
44359840 165446 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 395 4 2 5 3.5 O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 10.1021/jm00163a069
CHEMBL423918 165446 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 395 4 2 5 3.5 O=C1Nc2ccccc2C(c2ccccc2F)=NC1CNc1cnc(Cl)cn1 10.1021/jm00163a069
44370505 51278 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 543 10 2 4 6.3 O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 10.1021/jm00164a020
CHEMBL158078 51278 None 0 Human Binding pIC50 = 4 4.0 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 543 10 2 4 6.3 O=C(CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1)OCc1ccccc1 10.1021/jm00164a020
44280270 99216 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281560 99216 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280193 103129 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30784 103129 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10474221 16847 None 0 Rat Binding pIC50 = 5 5.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124822 16847 None 0 Rat Binding pIC50 = 5 5.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44281084 112690 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33043 112690 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 497 8 3 4 3.3 O=C(O)CNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10482726 26139 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 551 7 3 4 5.0 O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 10.1021/jm00078a018
CHEMBL135638 26139 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 551 7 3 4 5.0 O=C(CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21)NCc1ccccc1 10.1021/jm00078a018
44349278 16604 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Concentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortexConcentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortex
ChEMBL 388 10 3 3 3.3 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
CHEMBL124090 16604 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Concentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortexConcentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortex
ChEMBL 388 10 3 3 3.3 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
44349412 16863 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 12 3 3 3.6 CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124917 16863 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 12 3 3 3.6 CCCCC(CC)CNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44382371 120499 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL354442 120499 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44281292 114792 None 0 Mouse Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33398 114792 None 0 Mouse Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44357198 115236 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 478 6 4 5 3.0 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CO)C1=O 10.1021/jm00078a018
CHEMBL334735 115236 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 478 6 4 5 3.0 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CO)C1=O 10.1021/jm00078a018
10603714 156516 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL406790 156516 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4c(F)cccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44349325 168546 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 465 7 3 4 3.1 O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL435587 168546 None 0 Rat Binding pIC50 = 5.0 5.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 465 7 3 4 3.1 O=C(O)CCC(NC(=O)c1cccc(Br)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44280380 99838 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285657 99838 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 11 3 4 4.8 CCCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44283087 120822 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 8 2 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 10.1021/jm00086a017
CHEMBL35580 120822 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 8 2 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)OCCc1ccccc1 10.1021/jm00086a017
10249484 22652 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL132699 22652 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccncc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10646538 97365 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 6 3 6 4.1 CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL269606 97365 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 6 3 6 4.1 CC(C)Oc1cccc(-n2c(NNC(=O)NC3CCCCC3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44280244 13224 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL1191257 13224 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
CHEMBL542330 13224 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2cccnc12 10.1021/jm950372w
44283055 99754 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL285049 99754 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44283150 165243 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 3 4 4.7 CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 10.1021/jm00086a017
CHEMBL422941 165243 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 3 4 4.7 CN(C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(CO)Cc1ccccc1 10.1021/jm00086a017
44283514 170615 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 585 12 3 4 6.0 CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL445094 170615 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 585 12 3 4 6.0 CC(Cc1c[nH]c2ccccc12)(CN(CCc1ccccc1)C(=O)CCC(=O)O)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10738855 206609 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 385 4 3 5 3.8 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
CHEMBL8905 206609 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 385 4 3 5 3.8 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
44382038 120458 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL354040 120458 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
443375 207604 None 45 Rat Binding pIC50 = 6.0 6.0 -389 5
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(96)00160-6
CHEMBL9506 207604 None 45 Rat Binding pIC50 = 6.0 6.0 -389 5
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/0960-894X(96)00160-6
CHEMBL408083 212696 None 0 Human Binding pIC50 = 6.0 6.0 -3 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
16100406 83222 None 0 Human Binding pIC50 = 6.0 6.0 -281 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218600 83222 None 0 Human Binding pIC50 = 6.0 6.0 -281 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
10551234 96939 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 6 4.6 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL266120 96939 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 6 4.6 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
10455303 115218 None 8 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL334592 115218 None 8 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2cccc([N+](=O)[O-])c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10005779 116662 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 489 6 3 4 3.8 CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337065 116662 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 489 6 3 4 3.8 CCNC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280996 99742 None 0 Human Binding pIC50 = 8.0 8.0 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284976 99742 None 0 Human Binding pIC50 = 8.0 8.0 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
11555184 166030 None 0 Dog Binding pIC50 = 8.0 8.0 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL425574 166030 None 0 Dog Binding pIC50 = 8.0 8.0 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
145990693 166971 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4287572 166971 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
44333305 5049 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 502 4 2 5 3.6 CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL105273 5049 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 502 4 2 5 3.6 CCCN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
44210424 119216 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL34335 119216 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
73351320 106144 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
CHEMBL313559 106144 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
14843036 100159 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 413 5 1 4 4.8 COc1cccc(-n2c(CCc3c[nH]c4ccc(F)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL287914 100159 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 413 5 1 4 4.8 COc1cccc(-n2c(CCc3c[nH]c4ccc(F)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14843048 117243 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL33948 117243 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
44210424 119216 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL34335 119216 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00234-K
44279809 98965 None 0 Human Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL279778 98965 None 0 Human Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL319814 211221 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689734 106607 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL3142899 106607 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL319814 211221 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
44381201 161674 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL413186 161674 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
14843041 125040 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36436 125040 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
73354298 96669 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL263876 96669 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10031700 12188 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 7 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL1184246 12188 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 7 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL340975 12188 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 7 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC[N+](C)(C)C)C2=O)c1 10.1021/jm00078a018
10070678 120753 None 1 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL355092 120753 None 1 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44334452 4557 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 497 9 2 3 5.6 Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102461 4557 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 497 9 2 3 5.6 Cc1cccc(NC(=O)N[C@H](CCCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
15689738 106601 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142705 106601 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
10320031 77823 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL2092868 77823 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
14208307 77822 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092867 77822 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208216 102701 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 393 3 1 4 3.5 CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL304768 102701 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 393 3 1 4 3.5 CN1C(=O)C(NC(=O)c2ccsc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208210 204201 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 413 3 2 4 4.1 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 10.1021/jm00120a002
CHEMBL70856 204201 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 413 3 2 4 4.1 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2o1 10.1021/jm00120a002
44375135 52756 None 0 Mouse Binding pIC50 = 5.0 5.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 520 12 6 7 2.7 O=C(O)CCCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL159469 52756 None 0 Mouse Binding pIC50 = 5.0 5.0 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 520 12 6 7 2.7 O=C(O)CCCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
15104606 9455 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 10.1021/jm00116a002
CHEMBL111837 9455 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc2ccccc2c1 10.1021/jm00116a002
10364355 27949 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 4 2 3 3.9 C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 10.1021/jm00078a018
CHEMBL137208 27949 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 4 2 3 3.9 C[C@H](NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O)c1ccccc1 10.1021/jm00078a018
15200522 120466 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354126 120466 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
44382008 59048 None 0 Human Binding pIC50 = 5.0 5.0 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL169438 59048 None 0 Human Binding pIC50 = 5.0 5.0 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
44280502 99384 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL282639 99384 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 14 4 5 4.8 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
10253714 25492 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 460 4 2 3 5.3 CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135060 25492 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 460 4 2 3 5.3 CN1C(=O)C(NC(=O)Nc2cccc(-c3ccccc3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10722103 111472 None 0 Human Binding pIC50 = 5.0 5.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 588 8 1 6 5.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL327656 111472 None 0 Human Binding pIC50 = 5.0 5.0 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 588 8 1 6 5.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ncccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44327456 207840 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 11 2 5 5.7 COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL96401 207840 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 11 2 5 5.7 COC(=O)CCN(CCc1ccccc1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
155560670 175090 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4568746 175090 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 17 23 4.2 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
44279810 103842 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30917 103842 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
73354298 96669 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL263876 96669 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10074366 120596 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 120596 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 120596 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44329518 208332 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 560 6 3 3 6.2 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL99311 208332 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 560 6 3 3 6.2 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2ccc(Cl)cc2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
10622006 206762 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
CHEMBL9010 206762 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
44382327 59355 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL170777 59355 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 436 5 2 4 2.8 COc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44283515 100173 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 8 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 10.1021/jm00086a017
CHEMBL288038 100173 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 8 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)SCCc1ccccc1 10.1021/jm00086a017
44280000 103251 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30844 103251 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 525 10 3 4 4.0 O=C(O)CCCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10319892 59089 None 2 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL169661 59089 None 2 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL2386884 210394 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCCCC(CCCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
10010811 106606 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
CHEMBL3142898 106606 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 854 21 9 9 3.5 CC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
73349791 205805 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 664 13 5 6 5.2 CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
CHEMBL83244 205805 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 664 13 5 6 5.2 CCOP(=O)(O)CC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
73348230 206360 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 634 11 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL87470 206360 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 634 11 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
73346731 81544 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL216079 81544 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10647112 163421 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 3 3 4 4.1 Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL419663 163421 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 3 3 4 4.1 Cc1cccc(NC(=O)N[C@@H]2N=C([C@H]3CCC(C)(C)CCN3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
9896825 102975 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30656 102975 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
10319892 59089 None 2 Human Binding pIC50 = 7.9 7.9 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL169661 59089 None 2 Human Binding pIC50 = 7.9 7.9 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
9805700 119153 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 492 6 3 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 10.1021/jm970065l
CHEMBL342932 119153 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 492 6 3 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCCC1 10.1021/jm970065l
19766169 165564 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL424211 165564 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
14208237 204211 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 498 6 2 5 3.8 CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL70883 204211 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 498 6 2 5 3.8 CCOC(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14991586 100637 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 838 21 7 9 3.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292071 100637 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 838 21 7 9 3.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44334248 4678 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 528 8 3 5 4.9 Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL103312 4678 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 528 8 3 5 4.9 Cc1cccc(NC(=O)N[C@H](COC(=O)Nc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL262767 210546 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00113a023
44382486 59418 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 11 4 4 2.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
CHEMBL171051 59418 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 11 4 4 2.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
11803697 106614 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
136898911 106614 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3142912 106614 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL262767 210546 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
CHEMBL262767 210546 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00173a006
44311939 204493 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL72526 204493 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44377790 119980 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
CHEMBL349888 119980 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
73346732 169919 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL444113 169919 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
11742520 29624 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00078a018
CHEMBL138592 29624 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccccc1NC(=O)NC1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00078a018
10094138 168328 None 8 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL434255 168328 None 8 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2[N+](=O)[O-])N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
14991569 98797 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 863 20 9 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL278447 98797 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 863 20 9 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349011 116858 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 373 8 4 3 2.7 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00079a003
CHEMBL338134 116858 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 373 8 4 3 2.7 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00079a003
44349070 164489 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL421438 164489 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
13822916 189724 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
CHEMBL51569 189724 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 421 3 1 4 5.3 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
44381202 161829 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL414523 161829 None 0 Rat Binding pIC50 = 4.9 4.9 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
15104594 10121 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL115656 10121 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
11729474 4669 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 420 2 2 5 2.1 Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL103229 4669 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 420 2 2 5 2.1 Cc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
44396746 127058 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 127058 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
10839347 30259 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 10.1021/jm970065l
CHEMBL139101 30259 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 7 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCCC1 10.1021/jm970065l
44280992 100117 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL287564 100117 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
44283081 99869 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL2112071 99869 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL285880 99869 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
10761732 75944 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 371 4 3 5 3.5 O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 10.1021/jm970373j
CHEMBL2051984 75944 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 371 4 3 5 3.5 O=C(NNc1nc2ccccc2c(=O)n1-c1ccccc1)Nc1ccccc1 10.1021/jm970373j
44283246 99960 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286442 99960 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44303515 102091 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 571 9 2 5 5.3 CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL302194 102091 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 571 9 2 5 5.3 CN(C)C(=O)c1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
49798104 10843 None 0 Human Binding pIC50 = 6.9 6.9 7 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172244 10843 None 0 Human Binding pIC50 = 6.9 6.9 7 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172249 208580 None 0 Human Binding pIC50 = 6.9 6.9 -16 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172252 208582 None 0 Human Binding pIC50 = 6.9 6.9 -173 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172253 208583 None 0 Human Binding pIC50 = 6.9 6.9 -851 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
44283152 99852 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 501 10 4 4 4.8 O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL285762 99852 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 501 10 4 4 4.8 O=C(NC(CNC(CO)Cc1ccccc1)Cc1c[nH]c2ccccc12)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44381892 12274 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 510 9 2 4 3.7 CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1184772 12274 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 510 9 2 4 3.7 CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL368133 12274 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 510 9 2 4 3.7 CN(C)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
44279985 103101 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL30764 103101 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 3 4 3.6 CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
11755707 57520 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 500 8 2 7 4.7 CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
CHEMBL166168 57520 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 500 8 2 7 4.7 CCOC(=O)c1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
10074366 120596 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 120596 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 120596 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44396624 123884 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 559 7 2 6 4.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
CHEMBL362769 123884 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 559 7 2 6 4.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
155514432 169863 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 2121 86 19 27 2.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4440303 169863 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 2121 86 19 27 2.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)[C@H](CCCCN)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10531430 112345 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C 10.1021/jm970265x
CHEMBL329407 112345 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1ccccc1N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)C(C)C 10.1021/jm970265x
10349938 162917 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 722 14 4 6 6.7 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL417412 162917 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 722 14 4 6 6.7 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)OCc1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00356-9
44279938 162623 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
CHEMBL416944 162623 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccc2ccccc2c1)C(=O)O 10.1021/jm950372w
44386117 131349 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL368803 131349 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
44333048 169255 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
CHEMBL441165 169255 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
73349806 96440 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL262155 96440 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44348764 168630 None 0 Bovine Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 980 28 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL436199 168630 None 0 Bovine Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 980 28 11 11 1.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10052234 67760 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL1907927 67760 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 515 5 2 4 4.3 O=C(Nc1ccc(Cl)cc1)N[C@H]1N=C(c2ccccc2)c2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1021/jm00078a018
44368541 168614 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 590 13 5 5 4.5 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL436065 168614 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 590 13 5 5 4.5 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
73349872 89199 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/S0960-894X(97)00107-8
CHEMBL2367718 89199 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/S0960-894X(97)00107-8
CHEMBL2367719 89199 None 1 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/S0960-894X(97)00107-8
10370499 36950 None 0 Mouse Binding pIC50 = 7.9 7.9 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL145133 36950 None 0 Mouse Binding pIC50 = 7.9 7.9 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
10370499 36950 None 0 Mouse Binding pIC50 = 7.9 7.9 - 1
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL145133 36950 None 0 Mouse Binding pIC50 = 7.9 7.9 - 1
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
10370499 85988 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL2304064 85988 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
155517868 170209 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445353 170209 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1893 76 19 24 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
9887120 204124 None 4 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL70380 204124 None 4 Human Binding pIC50 = 6.9 6.9 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
10324540 16588 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
CHEMBL123981 16588 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 524 5 3 3 5.8 CC(C)(C)NC(=O)CN1C(=O)[C@@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](C2CCCCC2)c2ccccc21 10.1021/jm00048a015
14843054 119962 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 503 6 1 5 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1OC 10.1021/jm00108a040
CHEMBL34979 119962 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 503 6 1 5 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1OC 10.1021/jm00108a040
44356972 27654 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 555 7 3 7 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL136990 27654 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 555 7 3 7 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)ON3CCC[C@@H]3C(=O)O)C2=O)c1 10.1021/jm00078a018
15689734 106607 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
CHEMBL3142899 106607 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 9 3.5 CC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
15167816 204494 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL72546 204494 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44382561 168304 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 10.1016/S0960-894X(00)80687-3
CHEMBL434113 168304 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(O)cc1 10.1016/S0960-894X(00)80687-3
14843038 138206 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 138206 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL338056 211602 None 0 Bovine Binding pIC50 = 5.9 5.9 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
44280374 102865 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
CHEMBL30575 102865 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1cccc(C(=O)O)c1 10.1021/jm950372w
44210428 59112 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL169794 59112 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
14208288 67681 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 349 2 1 3 3.0 CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907660 67681 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 349 2 1 3 3.0 CN1C(=O)[C@@H](NC(=O)C(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44382560 120315 None 0 Mouse Binding pIC50 = 4.9 4.9 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 660 14 4 4 6.5 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL352817 120315 None 0 Mouse Binding pIC50 = 4.9 4.9 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 660 14 4 4 6.5 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCc1ccccc1 10.1016/S0960-894X(00)80687-3
44370473 50860 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL157722 50860 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
44283496 100172 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 9 2 3 6.1 CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL288037 100172 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 9 2 3 6.1 CC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44408525 169426 None 0 Human Binding pIC50 = 5.9 5.9 -56 3
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL442483 169426 None 0 Human Binding pIC50 = 5.9 5.9 -56 3
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
10624013 33536 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 464 6 3 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 10.1021/jm970065l
CHEMBL142063 33536 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 464 6 3 4 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCC1 10.1021/jm970065l
10886229 78591 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 10.1021/jm010813d
CHEMBL2112234 78591 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1cccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)c1 10.1021/jm010813d
44329150 112399 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 580 7 3 3 6.8 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL329735 112399 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 580 7 3 3 6.8 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
16100409 83232 None 0 Human Binding pIC50 = 4.9 4.9 - 3
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218651 83232 None 0 Human Binding pIC50 = 4.9 4.9 - 3
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44280894 113508 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL33209 113508 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 19 3 5 6.6 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280213 101616 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29888 101616 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44281005 116729 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL33743 116729 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
44280915 100277 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL289008 100277 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 676 10 3 5 5.2 O=C(O)C[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280205 13066 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL1190133 13066 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
CHEMBL540261 13066 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 695 12 4 6 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ncccc12 10.1021/jm950372w
44279811 96923 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL265987 96923 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44403829 71450 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
CHEMBL196143 71450 None 0 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
10453063 106989 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL315214 106989 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10673193 98142 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL273693 98142 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
10453063 106989 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL315214 106989 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 391 2 2 4 3.0 Cc1cccc(NC(=O)NC2N=C(N3CCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
10671800 206741 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL8997 206741 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Cl)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10094721 206892 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 439 5 3 7 3.5 CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9083 206892 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 439 5 3 7 3.5 CN(C)c1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10649303 207454 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9422 207454 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10838356 207642 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
CHEMBL9524 207642 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
73349789 106135 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1021/jm00092a007
CHEMBL313499 106135 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1021/jm00092a007
14802536 157329 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112694 157329 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL407753 157329 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCCC(=O)O)c1ccccc1 10.1021/jm00105a062
73354298 96669 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL263876 96669 None 0 Rat Binding pIC50 = 7.9 7.9 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44280214 107300 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31726 107300 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
15673181 85994 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304156 85994 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 8.6 to 32
ChEMBL 629 12 6 6 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)NO)c1ccccc1 10.1016/S0960-894X(00)80652-6
9827037 78827 None 8 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O 10.1021/jm970065l
CHEMBL2112795 78827 None 8 Mouse Binding pIC50 = 7.9 7.9 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCC[C@@H]1O 10.1021/jm970065l
9978327 78814 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 4 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112753 78814 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 4 3.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44381641 168639 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL436253 168639 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
10673193 98142 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL273693 98142 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 506 6 2 5 5.3 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44373702 119924 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL349473 119924 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@]1(C(=O)O)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL2310857 209487 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1CC(OS(=O)(=O)O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
44368382 45337 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL152682 45337 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44280111 99967 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
CHEMBL286510 99967 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc2C1 10.1021/jm950372w
15689729 106595 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 890 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142695 106595 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 890 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Br)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL320868 211227 None 0 Human Binding pIC50 = 5.9 5.9 - 2
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689733 106612 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
CHEMBL3142905 106612 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
CHEMBL3142923 211135 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL320868 211227 None 0 Human Binding pIC50 = 5.9 5.9 - 2
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
44381695 120836 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 811 20 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL355836 120836 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 811 20 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
65987 99575 None 13 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL283820 99575 None 13 Human Binding pIC50 = 5.9 5.9 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
136026477 206046 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 499 5 1 4 6.6 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL85250 206046 None 0 Mouse Binding pIC50 = 5.9 5.9 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 499 5 1 4 6.6 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
14208194 163434 None 2 Human Binding pIC50 = 5.9 5.9 - 2
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL419764 163434 None 2 Human Binding pIC50 = 5.9 5.9 - 2
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL320868 211227 None 0 Human Binding pIC50 = 5.9 5.9 - 2
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
73345199 141743 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL385918 141743 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
65987 99575 None 13 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283820 99575 None 13 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 440 6 2 3 4.1 O=C(O)CC[C@@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
14991571 202934 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 905 21 8 10 3.9 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
CHEMBL62887 202934 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 905 21 8 10 3.9 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
14208214 165246 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 10.1021/jm00120a002
CHEMBL422951 165246 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc2ccccc2c1 10.1021/jm00120a002
14208204 204463 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
CHEMBL72300 204463 None 0 Human Binding pIC50 = 4.9 4.9 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
44209151 59432 None 1 Human Binding pIC50 = 4.9 4.9 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL171108 59432 None 1 Human Binding pIC50 = 4.9 4.9 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44303299 201249 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 598 11 4 6 5.5 CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL60386 201249 None 0 Mouse Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 598 11 4 6 5.5 CC(Cc1ccc(Oc2ccccc2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44279937 104860 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31101 104860 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44329330 107185 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL316504 107185 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(C)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
52949124 875 None 4 Human Binding pIC50 = 6.9 6.9 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pIC50 = 6.9 6.9 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pIC50 = 6.9 6.9 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pIC50 = 6.9 6.9 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44280368 96895 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL265740 96895 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccc(C(=O)O)cc1 10.1021/jm950372w
11742839 12822 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL1188361 12822 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL536245 12822 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 419 2 2 4 3.7 Cc1cccc(NC(=O)N[C@H]2N=C(N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
44280397 103674 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30875 103674 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL262172 210526 None 0 Human Binding pIC50 = 6.8 6.8 -691 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
14888709 77248 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1031 30 11 12 0.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079603 77248 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1031 30 11 12 0.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44280103 167956 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL431692 167956 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 8 2 4 5.4 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1C(=O)O 10.1021/jm950372w
44331954 4450 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 508 12 2 3 4.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCCC1 10.1016/S0960-894X(96)00546-X
CHEMBL101681 4450 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 508 12 2 3 4.8 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCCC1 10.1016/S0960-894X(96)00546-X
44368567 168733 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL437039 168733 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10574611 207249 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9291 207249 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccccc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10838217 207332 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 10.1021/jm970373j
CHEMBL9354 207332 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)c1 10.1021/jm970373j
44330731 208242 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 946 25 9 11 0.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98720 208242 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 946 25 9 11 0.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CC[C@H](NC(=O)CCc2ccc(OS(=O)(=O)O)cc2)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
73351326 82381 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217234 82381 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44368382 45337 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL152682 45337 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10672231 205955 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 475 5 3 4 4.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL84433 205955 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 475 5 3 4 4.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL208479 209197 None 0 Human Binding pIC50 = 7.8 7.8 -5 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL218763 209397 None 0 Human Binding pIC50 = 7.8 7.8 -15 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
155534993 171993 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1385 38 16 19 -3.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4471171 171993 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1385 38 16 19 -3.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
71719689 85987 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 500 8 3 4 4.8 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 10.1016/S0960-894X(01)80769-1
CHEMBL2304063 85987 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 500 8 3 4 4.8 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccn1 10.1016/S0960-894X(01)80769-1
155548021 173662 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)n1cc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4534788 173662 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)n1cc(CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
10454826 99337 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL282294 99337 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
10415786 169716 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 577 7 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 10.1021/jm950626d
CHEMBL443825 169716 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 577 7 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(O)cc1 10.1021/jm950626d
44210427 120766 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL355319 120766 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
11803746 106611 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
CHEMBL3142904 106611 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
9887120 204124 None 4 Mouse Binding pIC50 = 6.8 6.8 - 0
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
CHEMBL70380 204124 None 4 Mouse Binding pIC50 = 6.8 6.8 - 0
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
14843030 100284 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 379 4 1 3 5.0 Cc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL289053 100284 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 379 4 1 3 5.0 Cc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
9887120 204124 None 4 Human Binding pIC50 = 6.8 6.8 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
CHEMBL70380 204124 None 4 Human Binding pIC50 = 6.8 6.8 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
CHEMBL320868 211227 None 0 Human Binding pIC50 = 5.8 5.8 - 2
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
14208284 67734 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 375 3 1 3 3.5 CN1C(=O)[C@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907838 67734 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 375 3 1 3 3.5 CN1C(=O)[C@H](NC(=O)C2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14444021 106673 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL3143386 106673 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
73346732 169919 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL444113 169919 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44283159 100132 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 8 3 3 6.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 10.1021/jm00086a017
CHEMBL287682 100132 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 8 3 3 6.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)/C(S)=N/CCc1ccccc1 10.1021/jm00086a017
44362746 118989 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
CHEMBL342520 118989 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
90663994 106821 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 837 21 8 8 3.6 Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144563 106821 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 837 21 8 8 3.6 Cc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
44334224 5053 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 480 7 2 5 3.3 Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105303 5053 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 480 7 2 5 3.3 Cc1cccc(NC(=O)N[C@H](COC(=O)N(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL3142685 211126 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44366345 119483 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uM
ChEMBL 447 6 2 2 5.8 O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL345327 119483 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 9.8-25 uM
ChEMBL 447 6 2 2 5.8 O=C1[C@@H](Cc2c[nH]c3ccccc23)CN(Cc2ccccc2)C[C@H]1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL355608 211737 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
CHEMBL436451 213679 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
44366108 43954 None 0 Human Binding pIC50 = 4.8 4.8 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
CHEMBL151276 43954 None 0 Human Binding pIC50 = 4.8 4.8 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCc1ccccc1 10.1021/jm00123a003
44377588 120143 None 0 Human Binding pIC50 = 4.8 4.8 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 15 7 6 3.7 CCCC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
CHEMBL351313 120143 None 0 Human Binding pIC50 = 4.8 4.8 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 15 7 6 3.7 CCCC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00388a002
14208231 204244 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL71079 204244 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
9887120 204124 None 4 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL70380 204124 None 4 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
9887120 204124 None 4 Human Binding pIC50 = 6.8 6.8 - 0
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
CHEMBL70380 204124 None 4 Human Binding pIC50 = 6.8 6.8 - 0
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
10551230 207307 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 7 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
CHEMBL9336 207307 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 443 6 3 7 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
44303237 100805 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL293178 100805 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44408526 136943 None 0 Human Binding pIC50 = 5.8 5.8 -1862 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL374325 136943 None 0 Human Binding pIC50 = 5.8 5.8 -1862 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
44280509 99402 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
CHEMBL282732 99402 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 588 10 3 5 4.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm950372w
44280117 102049 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30195 102049 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
9802550 119174 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 2 3 4.4 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
CHEMBL343066 119174 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 2 3 4.4 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
44303652 200688 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 570 8 2 3 7.2 CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL59985 200688 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 570 8 2 3 7.2 CC(Cc1ccc2c(c1)C(C)(C)CCC2(C)C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
44280363 102338 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30369 102338 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 8 2 4 3.6 CN(CC(=O)O)C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280176 99308 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282099 99308 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 615 12 3 4 5.6 O=C(O)CCC(Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280350 99850 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285739 99850 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10746778 47558 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 646 8 2 6 5.2 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 10.1021/jm950626d
CHEMBL154615 47558 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 646 8 2 6 5.2 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(N2CCOCC2)cc1 10.1021/jm950626d
44365304 164750 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 444 8 2 3 4.3 CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
CHEMBL421778 164750 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 444 8 2 3 4.3 CC(C)N(C(=O)CN(C(=O)CNC(=O)Nc1ccccc1)c1ccccc1)c1ccccc1 10.1016/S0960-894X(97)00062-0
44265901 207520 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9459 207520 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
71580808 90423 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL 842 26 8 8 1.6 C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2013.02.022
CHEMBL2386888 90423 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL 842 26 8 8 1.6 C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2013.02.022
73349792 157412 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 669 13 5 7 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
CHEMBL407857 157412 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 669 13 5 7 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
44331065 107224 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 25 8 11 1.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL316709 107224 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 25 8 11 1.3 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
44300551 197393 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 390 3 2 3 4.1 Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL56944 197393 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 390 3 2 3 4.1 Cc1cccc(NC(=O)NC2N=C(C3CCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
73351327 82423 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217424 82423 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
14843045 133549 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37096 133549 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10480792 45798 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153095 45798 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3350686 45798 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 CC1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44329456 111443 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL327526 111443 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44280200 100822 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29331 100822 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
19766167 59233 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL170293 59233 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
71458029 78788 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112692 78788 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
4355450 135925 None 50 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37312 135925 None 50 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14843032 138899 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 395 5 1 4 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37829 138899 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 395 5 1 4 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14802537 59081 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL169615 59081 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
44280116 99630 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL284183 99630 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44280741 156560 None 0 Mouse Binding pIC50 = 6.8 6.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL406844 156560 None 0 Mouse Binding pIC50 = 6.8 6.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44334305 109717 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 514 9 3 4 4.6 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL322913 109717 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 514 9 3 4 4.6 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
15689723 106593 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142693 106593 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14208227 102262 None 1 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 440 3 1 4 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL303227 102262 None 1 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 440 3 1 4 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14843042 127573 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36634 127573 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 485 5 1 3 6.5 CCc1cccc(-n2c(CC(C)c3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44349268 16784 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 399 9 3 4 3.1 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 10.1021/jm00079a003
CHEMBL124509 16784 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 399 9 3 4 3.1 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cnc2ccccc2c1 10.1021/jm00079a003
44381914 13001 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 522 14 1 4 4.7 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
CHEMBL1189721 13001 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 522 14 1 4 4.7 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
CHEMBL539320 13001 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 522 14 1 4 4.7 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
44396746 127058 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL365620 127058 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 637 8 2 6 5.7 C[C@H]1C(=O)N(c2ccc(N(C)C)cc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44349354 118549 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 8 3 4 2.9 CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL341505 118549 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 8 3 4 2.9 CCc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
44349335 117311 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 401 7 3 4 2.6 Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL339707 117311 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 401 7 3 4 2.6 Cc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
44331978 4290 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 449 12 3 3 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL100762 4290 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 449 12 3 3 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(96)00546-X
73345199 141743 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL385918 141743 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44349390 17455 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 417 8 3 5 2.3 COc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL125770 17455 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 417 8 3 5 2.3 COc1cccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
10699165 111451 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 625 7 1 4 6.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 10.1021/jm970265x
CHEMBL327552 111451 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 625 7 1 4 6.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(F)(F)F)cc1 10.1021/jm970265x
44359338 168664 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
CHEMBL436411 168664 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
44280180 102631 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30430 102631 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL292097 210883 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(01)81005-2
6957640 159359 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL410035 159359 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 404 3 2 3 4.5 Cc1cccc(NC(=O)N[C@H]2N=C(C3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
16100407 82669 None 0 Human Binding pIC50 = 6.8 6.8 -112 3
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL217957 82669 None 0 Human Binding pIC50 = 6.8 6.8 -112 3
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44279852 99360 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL282476 99360 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.6 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10603713 111646 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL328586 111646 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cccc(F)c34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL282175 99319 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 769 16 6 11 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCSCc3csc(C=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00249-1
44331850 208250 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 600 13 3 4 4.7 O=C(Cc1c[nH]c2ccccc12)N[C@@H](CCc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL98788 208250 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 600 13 3 4 4.7 O=C(Cc1c[nH]c2ccccc12)N[C@@H](CCc1ccccc1)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
145988494 167181 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 425 5 2 7 3.6 CCOc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4291306 167181 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 425 5 2 7 3.6 CCOc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL263155 210558 None 0 Bovine Binding pIC50 = 6.8 6.8 - 0
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
444998 209317 None 30 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL216166 209317 None 30 Human Binding pIC50 = 6.8 6.8 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
443375 207604 None 45 Human Binding pIC50 = 6.8 6.8 -316 5
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.8 6.8 -316 5
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44354128 20292 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL130578 20292 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
14802521 59082 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL169616 59082 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
44356717 116778 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 5 3 5 4.7 CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337722 116778 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 513 5 3 5 4.7 CN1C(=O)C(NC(=O)Nc2cccc(CNC(=O)OC(C)(C)C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
367893 51618 None 1 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 429 14 3 3 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL158362 51618 None 1 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 429 14 3 3 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
443375 207604 None 45 Human Binding pIC50 = 6.8 6.8 -316 5
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00164a020
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.8 6.8 -316 5
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00164a020
44334320 5021 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 531 9 2 4 4.6 Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105132 5021 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 531 9 2 4 4.6 Cc1cccc(NC(=O)N[C@H](C[S+]([O-])Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL433365 213636 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O 10.1016/S0960-894X(96)00546-X
196641 204396 None 12 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL71950 204396 None 12 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
90663984 106812 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 21 8 8 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144553 106812 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 21 8 8 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663985 106813 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 22 8 9 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144554 106813 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 22 8 9 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
44279862 99128 None 0 Mouse Binding pIC50 = 5.8 5.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281017 99128 None 0 Mouse Binding pIC50 = 5.8 5.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
19766161 59181 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL170068 59181 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
1043 1580 None 14 Mouse Binding pIC50 = 4.8 4.8 - 29
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
149 1580 None 14 Mouse Binding pIC50 = 4.8 4.8 - 29
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
8223 1580 None 14 Mouse Binding pIC50 = 4.8 4.8 - 29
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
CHEMBL442 1580 None 14 Mouse Binding pIC50 = 4.8 4.8 - 29
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
DB00696 1580 None 14 Mouse Binding pIC50 = 4.8 4.8 - 29
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
CHEMBL435339 213663 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
14208200 204715 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 5 3 3 4.0 O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL74181 204715 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 5 3 3 4.0 O=C(CCc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
14720390 49388 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL156415 49388 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
44303653 100778 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 557 10 2 5 5.7 CN(C)Cc1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL292957 100778 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 557 10 2 5 5.7 CN(C)Cc1oc2ccccc2c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL379405 212263 None 0 Human Binding pIC50 = 5.8 5.8 -10 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44408411 161308 None 0 Human Binding pIC50 = 5.8 5.8 -3548 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL412331 161308 None 0 Human Binding pIC50 = 5.8 5.8 -3548 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
10817395 107140 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL316164 107140 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10817395 107140 None 0 Human Binding pIC50 = 4.8 4.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL316164 107140 None 0 Human Binding pIC50 = 4.8 4.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 600 8 1 4 6.9 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
52949124 875 None 4 Human Binding pIC50 = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pIC50 = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pIC50 = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pIC50 = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
73349808 161791 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL414180 161791 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44280375 99106 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
CHEMBL280832 99106 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccc(C(=O)O)cc1 10.1021/jm950372w
10768419 29106 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 525 10 5 5 3.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O 10.1021/jm970065l
CHEMBL138127 29106 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 525 10 5 5 3.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CC(=O)O)CC(=O)O 10.1021/jm970065l
44327699 207480 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 641 15 2 5 7.2 COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL94352 207480 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 641 15 2 5 7.2 COC(=O)CCCCCCN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
10698051 206529 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
CHEMBL88545 206529 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
10439504 92298 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 675 8 5 6 5.1 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL24276 92298 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 675 8 5 6 5.1 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
10032956 168034 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL432258 168034 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
10698051 206529 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm970265x
CHEMBL88545 206529 None 0 Human Binding pIC50 = 6.8 6.8 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 557 7 1 4 5.9 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm970265x
155539345 172831 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4514283 172831 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 72 16 23 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44210424 119216 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL34335 119216 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 423 4 2 4 3.8 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
22354599 194803 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL538912 194803 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 517 6 2 5 4.9 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1016/0960-894X(95)00557-A
71456207 78622 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112331 78622 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1c[nH]nn1)c1ccccc1 10.1021/jm00092a007
73349808 161791 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL414180 161791 None 0 Rat Binding pIC50 = 7.8 7.8 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
14888721 77235 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079551 77235 None 0 Bovine Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44318235 12075 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 513 7 2 4 3.0 CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 10.1021/jm9608523
CHEMBL1183721 12075 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 513 7 2 4 3.0 CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 10.1021/jm9608523
CHEMBL314846 12075 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 513 7 2 4 3.0 CCN(CC)C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(c2cccc[n+]2C)c2ccccc21 10.1021/jm9608523
44333311 4257 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 476 6 2 5 3.5 CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL100502 4257 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 476 6 2 5 3.5 CCCc1cccc(NC(=O)NC2N=C(N3CCN(C)CC3)c3ccccc3N(CCC)C2=O)c1 10.1016/0960-894X(95)00530-0
155550030 173900 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4540191 173900 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
19766169 165564 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL424211 165564 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 443 4 2 4 4.2 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
14208286 67682 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 395 4 1 3 3.7 CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907661 67682 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 395 4 1 3 3.7 CN1C(=O)[C@@H](NC(=O)/C=C/c2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44354127 116733 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL337461 116733 None 0 Mouse Binding pIC50 = 6.8 6.8 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
14802522 59570 None 0 Mouse Binding pIC50 = 6.8 6.8 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL171806 59570 None 0 Mouse Binding pIC50 = 6.8 6.8 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
44381821 120623 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL354632 120623 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
44280740 100405 None 0 Mouse Binding pIC50 = 6.8 6.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL290122 100405 None 0 Mouse Binding pIC50 = 6.8 6.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44334225 4986 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 522 7 2 6 3.1 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL104958 4986 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 522 7 2 6 3.1 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCOCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208271 102893 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL305951 102893 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)C(NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44381201 161674 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL413186 161674 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1062 29 9 12 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)CCc1ccccc1 10.1016/S0960-894X(00)80679-4
44375217 56550 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 582 12 5 7 3.8 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163974 56550 None 0 Mouse Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 582 12 5 7 3.8 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
73349808 161791 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL414180 161791 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
90663977 106798 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 823 21 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144539 106798 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 823 21 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL169174 208834 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
14208199 103070 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 10.1021/jm00120a002
CHEMBL307370 103070 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1c[nH]c2ccccc12 10.1021/jm00120a002
14208246 204680 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
CHEMBL73892 204680 None 0 Human Binding pIC50 = 4.8 4.8 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 407 3 2 3 4.0 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
10462874 98834 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/S0960-894X(00)80687-3
CHEMBL278780 98834 None 0 Mouse Binding pIC50 = 4.8 4.8 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/S0960-894X(00)80687-3
44396655 122048 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
CHEMBL359589 122048 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 608 8 2 5 5.7 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC3C4CC5CC(C4)CC3C5)C12 10.1021/jm0498755
44280974 100005 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL286763 100005 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 690 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCC2CCCCC2C1 10.1021/jm950372w
44280225 99961 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286475 99961 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44280620 103914 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
CHEMBL30924 103914 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 686 15 4 5 5.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCCc1ccccc1 10.1021/jm950372w
44303511 159758 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 750 18 4 10 5.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
CHEMBL410511 159758 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 750 18 4 10 5.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
2802894 2401 None 33 Mouse Binding pIC50 = 7.7 7.7 - 0
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
3509 2401 None 33 Mouse Binding pIC50 = 7.7 7.7 - 0
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
CHEMBL333081 2401 None 33 Mouse Binding pIC50 = 7.7 7.7 - 0
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
71449099 78812 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 3 4 3.0 CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112751 78812 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 3 4 3.0 CN1C(=O)[C@H](NC(=O)NCc2cccc(O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44281292 114792 None 0 Human Binding pIC50 = 7.7 7.7 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33398 114792 None 0 Human Binding pIC50 = 7.7 7.7 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 816 17 5 9 5.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCNC(=O)CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
2802894 2401 None 33 Mouse Binding pIC50 = 7.7 7.7 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
3509 2401 None 33 Mouse Binding pIC50 = 7.7 7.7 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL333081 2401 None 33 Mouse Binding pIC50 = 7.7 7.7 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@H]([C@@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
145979412 166552 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 459 3 2 6 3.9 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Br)c1 10.1039/C7MD00171A
CHEMBL4279570 166552 None 0 Rat Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 459 3 2 6 3.9 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Br)c1 10.1039/C7MD00171A
9832467 144291 None 0 Dog Binding pIC50 = 7.7 7.7 -13 5
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL390519 144291 None 0 Dog Binding pIC50 = 7.7 7.7 -13 5
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
10319892 59089 None 2 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL169661 59089 None 2 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10838382 119329 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 478 6 3 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 10.1021/jm970065l
CHEMBL344211 119329 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 478 6 3 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CCCCC1 10.1021/jm970065l
10555387 30092 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 589 10 3 3 7.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1021/jm970065l
CHEMBL138952 30092 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 589 10 3 3 7.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1021/jm970065l
10032955 168033 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
CHEMBL432256 168033 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)NC(=O)CCC(=O)O 10.1021/jm00017a022
10093957 204632 None 1 Human Binding pIC50 = 6.7 6.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL73522 204632 None 1 Human Binding pIC50 = 6.7 6.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
73351326 82381 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217234 82381 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
14843053 100158 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 4 1 5 4.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccc2c(c1)OCO2 10.1021/jm00108a040
CHEMBL287913 100158 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 4 1 5 4.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccc2c(c1)OCO2 10.1021/jm00108a040
10369346 24966 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 10.1021/jm00078a018
CHEMBL134618 24966 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)cc1 10.1021/jm00078a018
44370694 48008 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL155017 48008 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
44329331 108063 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL319504 108063 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c3ccccc3)C2)cc1 10.1016/S0960-894X(01)80832-5
44280713 100030 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286907 100030 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
10769675 207197 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 10.1021/jm970265x
CHEMBL92586 207197 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 587 8 1 5 5.9 COc1cccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)c1 10.1021/jm970265x
CHEMBL319340 211214 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL2112688 209246 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
CHEMBL98468 215925 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00113a023
14208242 156421 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL40668 156421 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL98468 215925 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm960509y
CHEMBL103485 208455 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL319340 211214 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL98468 215925 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1 10.1021/jm00173a006
14208268 204482 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 418 3 2 4 3.5 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL72428 204482 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 418 3 2 4 3.5 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2N)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44375675 56504 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 605 12 4 7 4.9 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163506 56504 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 605 12 4 7 4.9 O=C(O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NC(c2ccccc2)c2ccccc2)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL319340 211214 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80687-3
15104620 111358 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
CHEMBL326979 111358 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
14208242 156421 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
CHEMBL40668 156421 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
3960 2343 None 23 Human Binding pIC50 = 5.7 5.7 - 1
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00164a020
891 2343 None 23 Human Binding pIC50 = 5.7 5.7 - 1
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00164a020
CHEMBL24938 2343 None 23 Human Binding pIC50 = 5.7 5.7 - 1
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00164a020
44349434 117013 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 11 3 3 3.6 CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL338929 117013 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 396 11 3 3 3.6 CCC(C)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44349087 118447 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 420 7 3 3 3.8 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm00079a003
CHEMBL341143 118447 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 420 7 3 3 3.8 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm00079a003
44382329 120624 None 1 Mouse Binding pIC50 = 5.7 5.7 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL354633 120624 None 1 Mouse Binding pIC50 = 5.7 5.7 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@H](c2ccccc2)[C@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
14208299 67740 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907844 67740 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208253 204707 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 10.1021/jm00120a002
CHEMBL74125 204707 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc(Cl)c1 10.1021/jm00120a002
14991542 106805 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 893 22 8 8 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144545 106805 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 893 22 8 8 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349353 116840 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 7 3 4 3.0 Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
CHEMBL338045 116840 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 415 7 3 4 3.0 Cc1cc(C)cc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)c1 10.1021/jm00079a003
10530400 119333 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 535 7 3 5 5.0 COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 10.1021/jm970065l
CHEMBL344220 119333 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 535 7 3 5 5.0 COC(=O)C1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)CCCCC1 10.1021/jm970065l
44303669 168287 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 573 10 4 5 3.9 O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL434020 168287 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 573 10 4 5 3.9 O=C(O)CCC(=O)N[C@@H](CNC(=O)C1(NC(=O)OC2C3CC4CC(C3)CC2C4)Cc2ccccc2C1)c1ccccc1 10.1016/S0960-894X(97)00356-9
10344702 28628 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 471 7 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL137714 28628 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 471 7 2 5 3.6 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
44283085 99904 None 0 Mouse Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 484 9 2 2 7.4 CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286093 99904 None 0 Mouse Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 484 9 2 2 7.4 CC(CCCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44283151 119165 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 531 9 4 4 5.6 O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL34300 119165 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 531 9 4 4 5.6 O=C(NC(Cc1c[nH]c2ccccc12)/C(S)=N/C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44365788 121691 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 643 7 1 7 5.5 COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 10.1021/jm9601664
CHEMBL358778 121691 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 643 7 1 7 5.5 COC(=O)n1c(C(=O)NC2C(=O)N(CC(=O)N(c3ccccc3)C(C)C)c3ccccc3N(c3ccccc3)C2=O)cc2ccccc21 10.1021/jm9601664
CHEMBL1172428 208584 None 0 Human Binding pIC50 = 6.7 6.7 -47 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172429 208585 None 0 Human Binding pIC50 = 6.7 6.7 -120 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL2372623 210275 None 0 Human Binding pIC50 = 6.7 6.7 -218 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
21842345 121701 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL358875 121701 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 522 6 2 4 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
5311201 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00121a004
5311201 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970517u
5311201 207393 None 35 Mouse Binding pIC50 = 8.7 8.7 -26 6
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 8.7 8.7 -26 6
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000937a
10053201 16590 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.9 CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL124004 16590 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 6 3 3 5.9 CCc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
5311201 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm020424z
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm020424z
CHEMBL274661 210813 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
CHEMBL274661 210813 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
44293811 185117 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 601 5 2 4 5.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL48563 185117 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 601 5 2 4 5.8 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(Cl)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
5311201 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00609-9
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00609-9
5311201 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Inhibition of cholecystokinin B receptorInhibition of cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/np9800102
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
Inhibition of cholecystokinin B receptorInhibition of cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/np9800102
5311201 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.7 8.7 -27 6
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80684-8
145979415 166557 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 6 3 6 4.9 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4279660 166557 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 6 3 6 4.9 CCOc1ccc(-n2c(NNC(=S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
155526914 171200 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4459331 171200 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1837 72 19 24 0.8 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
21842327 46041 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 468 6 2 4 4.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL153308 46041 None 0 Rat Binding pIC50 = 8.7 8.7 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 468 6 2 4 4.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)C)C2=O)c1 10.1016/0960-894X(95)00556-9
155532425 171746 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
CHEMBL4467338 171746 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1822 71 18 23 2.5 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01558
CHEMBL407057 212633 None 0 Human Binding pIC50 = 8.7 8.7 120 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm050921q
10369804 16758 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL124340 16758 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1cccc2c1N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
44349572 115057 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 533 5 2 4 6.0 Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL334305 115057 None 0 Human Binding pIC50 = 8.7 8.7 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 533 5 2 4 6.0 Cc1ccc2c(c1)N(CC(=O)OC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2c1ccccc1 10.1021/jm00048a015
10431936 93236 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2448131 93236 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL384035 212314 None 4 Rat Binding pIC50 = 8.6 8.6 -512 4
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL428666 212314 None 4 Rat Binding pIC50 = 8.6 8.6 -512 4
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80679-4
CHEMBL384035 212314 None 4 Rat Binding pIC50 = 8.6 8.6 -512 4
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
CHEMBL428666 212314 None 4 Rat Binding pIC50 = 8.6 8.6 -512 4
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00072a024
44332065 109713 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 552 13 3 4 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL322893 109713 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 552 13 3 4 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
44327450 168199 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 558 10 3 5 4.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O 10.1016/S0960-894X(01)80769-1
CHEMBL433384 168199 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 558 10 3 5 4.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccn1)CC(=O)O 10.1016/S0960-894X(01)80769-1
21842336 121516 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL358420 121516 None 0 Rat Binding pIC50 = 8.6 8.6 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 480 6 2 4 4.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
11799907 96997 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
CHEMBL266557 96997 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
CHEMBL1806531 208974 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1806532 208975 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
71458004 78626 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 670 12 5 8 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 10.1021/jm00092a007
CHEMBL2112335 78626 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 670 12 5 8 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCn1nn[nH]c1=S)c1ccccc1 10.1021/jm00092a007
44318205 205792 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 459 3 3 4 3.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL83130 205792 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 459 3 3 4 3.9 CN1C(=O)[C@H](NC(=O)Nc2ccc3c(c2)CCC3)N=C([C@H]2CC(C)(C)CCN2)c2ccccc21 10.1021/jm9608523
CHEMBL120632 208603 None 33 Mouse Binding pIC50 = 8.6 8.6 - 3
Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexConcentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(94)85022-4
56663263 64016 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1807150 64016 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1538 51 14 25 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
71454457 78621 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112330 78621 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 655 12 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1nc[nH]n1)c1ccccc1 10.1021/jm00092a007
10458620 114544 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 499 5 2 4 5.4 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1021/jm00048a015
CHEMBL333718 114544 None 0 Human Binding pIC50 = 8.6 8.6 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 499 5 2 4 5.4 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1021/jm00048a015
10625474 29224 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL138233 29224 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL5273681 193770 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity to human CCK2R expressed in human A-431 cellsBinding affinity to human CCK2R expressed in human A-431 cells
ChEMBL 1219 24 15 16 -0.0 CSCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)[C@H](NC(=O)c2ccc(NN)nc2)CCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2021.113538
10392653 119039 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL342640 119039 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
71449079 78625 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 639 11 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112334 78625 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 639 11 5 7 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)Cc1cc(O)no1)c1ccccc1 10.1021/jm00092a007
14802530 21615 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL131754 21615 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL205965 209167 None 0 Human Binding pIC50 = 8.6 8.6 31 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44300744 101951 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 542 6 4 4 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL301261 101951 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 542 6 4 4 4.7 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)O)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
10003805 107462 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Compound was tested for its binding affinity against gastrin receptor in guinea pig gastric glandsCompound was tested for its binding affinity against gastrin receptor in guinea pig gastric glands
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL318360 107462 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Compound was tested for its binding affinity against gastrin receptor in guinea pig gastric glandsCompound was tested for its binding affinity against gastrin receptor in guinea pig gastric glands
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
51353551 18132 None 16 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL1269257 18132 None 16 Human Binding pIC50 = 8.6 8.6 - 0
Displacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ2 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
19018662 26510 None 14 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 424 3 2 3 4.1 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136038 26510 None 14 Human Binding pIC50 = 8.6 8.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 424 3 2 3 4.1 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)CCC3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2369762 209678 None 0 Mouse Binding pIC50 = 8.6 8.6 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexConcentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None CCCCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(94)85022-4
5311201 207393 None 35 Human Binding pIC50 = 8.5 8.5 -27 6
Inhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranesInhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.5 8.5 -27 6
Inhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranesInhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
10815094 120397 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 495 5 3 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
CHEMBL353509 120397 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 495 5 3 7 3.2 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1N(C)c1nn[nH]n1 10.1021/jm9506736
44280599 99160 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL281206 99160 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44336539 5142 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
CHEMBL105775 5142 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
155536224 172157 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)n1cc([C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4473301 172157 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)n1cc([C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
10501974 96973 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 415 5 3 6 3.9 COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL266376 96973 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 415 5 3 6 3.9 COc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL411202 212871 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
44349069 118057 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL340413 118057 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
73351327 82423 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217424 82423 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
14888714 77247 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1067 30 11 12 0.9 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079602 77247 None 0 Bovine Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1067 30 11 12 0.9 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44303298 203299 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 522 9 5 6 3.5 CC(Cc1ccc(O)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL64770 203299 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 522 9 5 6 3.5 CC(Cc1ccc(O)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
14991572 163178 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 848 20 8 9 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL418123 163178 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 848 20 8 9 3.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44348808 17933 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL125925 17933 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44280996 99742 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284976 99742 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 745 14 4 8 5.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44279861 103182 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30821 103182 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44280373 99386 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282646 99386 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
155523323 170786 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 16 20 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)c1c[nH]nn1 10.1021/acs.jmedchem.9b01936
CHEMBL4453047 170786 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 16 20 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)c1c[nH]nn1 10.1021/acs.jmedchem.9b01936
CHEMBL3142681 211124 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142698 211132 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1/N=C(/S)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44349314 16565 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
CHEMBL123852 16565 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
44458120 98959 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 377 5 3 3 2.0 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
CHEMBL279730 98959 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 377 5 3 3 2.0 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
14208305 67742 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907846 67742 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208231 204244 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL71079 204244 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14444022 106672 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL3143385 106672 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
44365965 121698 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL358826 121698 None 0 Human Binding pIC50 = 5.7 5.7 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44334258 4462 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 451 8 3 4 3.5 Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL101752 4462 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 451 8 3 4 3.5 Cc1cccc(NC(=O)N[C@H](CCC(=O)O)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44334172 4567 None 1 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 556 10 3 5 4.9 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102526 4567 None 1 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 556 10 3 5 4.9 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208231 204244 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL71079 204244 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 3 1 4 3.7 CN1C(=O)C(NC(=O)c2cc3ccccc3n2C)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
14208230 103207 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 446 3 3 3 4.5 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 10.1021/jm00120a002
CHEMBL308414 103207 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 446 3 3 3 4.5 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1 10.1021/jm00120a002
44365993 44182 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL151619 44182 None 0 Human Binding pIC50 = 4.7 4.7 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 635 15 6 6 3.8 CC(C)C[C@@H](CC(=O)NC(CC(=O)O)C(=O)NCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
15104613 110313 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00116a002
CHEMBL323854 110313 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1c[nH]c2ccccc12 10.1021/jm00116a002
10076650 26230 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm050689o
CHEMBL13577 26230 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm050689o
10076650 26230 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
CHEMBL13577 26230 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
10076650 26230 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1016/s0960-894x(01)00630-8
CHEMBL13577 26230 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1016/s0960-894x(01)00630-8
44329486 112597 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL330197 112597 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3ccc(F)cc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44303651 200479 None 0 Mouse Binding pIC50 = 4.7 4.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 458 6 2 3 4.4 O=C(NC1(C(=O)NCCc2ccccc2)Cc2ccccc2C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
CHEMBL59859 200479 None 0 Mouse Binding pIC50 = 4.7 4.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 458 6 2 3 4.4 O=C(NC1(C(=O)NCCc2ccccc2)Cc2ccccc2C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
155562281 175839 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4585323 175839 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
73351326 82381 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217234 82381 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44279810 103842 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30917 103842 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
52949124 875 None 4 Human Binding pIC50 = 6.7 6.7 2 2
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pIC50 = 6.7 6.7 2 2
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pIC50 = 6.7 6.7 2 2
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pIC50 = 6.7 6.7 2 2
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44353183 116774 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700
ChEMBL 555 8 3 4 5.2 O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
CHEMBL337692 116774 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 1790-2700
ChEMBL 555 8 3 4 5.2 O=C(OC1C2CC3CC(C2)CC1C3)N1CCCC1(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
44349411 16841 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 380 7 3 3 3.1 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 10.1021/jm00079a003
CHEMBL124802 16841 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 380 7 3 3 3.1 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCC1 10.1021/jm00079a003
73354295 105944 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 643 13 5 6 4.5 CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
CHEMBL312894 105944 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 643 13 5 6 4.5 CONC(=O)CCC(=O)N[C@H](CNC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00092a007
10256428 119686 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL347278 119686 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL386811 212391 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
44368329 121001 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL356446 121001 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C(=O)NCCc1ccccc1 10.1021/jm00057a005
90663976 106797 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144538 106797 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccccc1O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280224 104782 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31090 104782 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL3142682 211125 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC1CCCCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14991574 100701 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 836 20 9 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292471 100701 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 836 20 9 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663992 106819 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 22 8 9 3.3 CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
CHEMBL3144561 106819 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 22 8 9 3.3 CN(C)c1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm00089a010
44280130 161277 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
CHEMBL412108 161277 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 670 11 3 5 5.0 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCc2ccccc21 10.1021/jm950372w
11797585 98454 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 445 6 3 7 3.9 COc1ccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)cc1OC 10.1021/jm970373j
CHEMBL275789 98454 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 445 6 3 7 3.9 COc1ccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)cc1OC 10.1021/jm970373j
10322621 57556 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 473 7 2 7 4.4 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL166443 57556 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 473 7 2 7 4.4 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc([N+](=O)[O-])cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
44280398 99243 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL281728 99243 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 2 4 5.2 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44280101 99591 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
CHEMBL283920 99591 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.3 O=C(O)Cc1cccc(NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)c1 10.1021/jm950372w
40652201 199089 None 0 Mouse Binding pIC50 = 5.7 5.7 - 1
Concentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortexConcentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortex
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL58852 199089 None 0 Mouse Binding pIC50 = 5.7 5.7 - 1
Concentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortexConcentration required for binding affinity to neuropeptide (CCK-B) receptor in mouse cerebral cortex
ChEMBL 407 9 3 3 4.2 CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
10530757 118561 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 553 10 3 7 3.6 COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL341560 118561 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 553 10 3 7 3.6 COC(=O)CC(CC(=O)OC)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
44280178 102620 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30422 102620 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280131 99590 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL283914 99590 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
44280214 107300 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31726 107300 None 0 Mouse Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 770 16 6 10 3.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44280225 99961 None 0 Mouse Binding pIC50 = 5.7 5.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286475 99961 None 0 Mouse Binding pIC50 = 5.7 5.7 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44349240 118115 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 11 3 3 3.0 CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL340755 118115 None 0 Rat Binding pIC50 = 4.7 4.7 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 11 3 3 3.0 CCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44280123 99271 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281903 99271 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44303488 101057 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 501 8 2 6 4.1 CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL294735 101057 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 501 8 2 6 4.1 CC(Cn1nnc2ccccc21)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
10077166 99932 None 0 Rat Binding pIC50 = 6.7 6.7 75 2
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL286247 99932 None 0 Rat Binding pIC50 = 6.7 6.7 75 2
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
44280157 155727 None 0 Rat Binding pIC50 = 6.7 6.7 75 2
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL405468 155727 None 0 Rat Binding pIC50 = 6.7 6.7 75 2
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL205306 209166 None 0 Human Binding pIC50 = 5.7 5.7 -109 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10668688 207530 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 400 4 4 6 3.4 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 10.1021/jm970373j
CHEMBL9465 207530 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 400 4 4 6 3.4 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N)c2)c1 10.1021/jm970373j
44280102 102707 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30481 102707 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccccc1)C(=O)O 10.1021/jm950372w
44387108 168252 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL433770 168252 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@@]1(Cc2ccccc2)C[C@H]2[C@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
10504136 206636 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL8922 206636 None 0 Mouse Binding pIC50 = 7.7 7.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
10791546 207081 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL9188 207081 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1021/jm970373j
CHEMBL438911 213804 None 0 Bovine Binding pIC50 = 7.7 7.7 - 0
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
10070677 161722 None 15 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL41361 161722 None 15 Human Binding pIC50 = 7.7 7.7 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
14888736 98084 None 0 Bovine Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 974 29 10 11 1.2 CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL273344 98084 None 0 Bovine Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 974 29 10 11 1.2 CSCC[C@H](NC(=O)CCc1ccc(CC(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44356868 25974 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C 10.1021/jm00078a018
CHEMBL135433 25974 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1C 10.1021/jm00078a018
10346957 26951 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 2 4 4.9 CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136436 26951 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 2 4 4.9 CCN(CC)C(=O)C(C)N1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44356801 165509 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.6 C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL424076 165509 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.6 C#Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44386486 130688 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL368356 130688 None 0 Rat Binding pIC50 = 6.7 6.7 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 650 9 3 5 4.7 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C34CC5CC(CC(C5)C3)C4)CCCN2C1=O 10.1016/0960-894X(96)00160-6
10253366 116343 None 13 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL335951 116343 None 13 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44281004 100077 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL287295 100077 None 0 Human Binding pIC50 = 6.7 6.7 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
19766168 59555 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL171722 59555 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
10474221 16847 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124822 16847 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44381489 97191 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL268337 97191 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
44382735 120761 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 646 13 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL355275 120761 None 0 Mouse Binding pIC50 = 5.7 5.7 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 646 13 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
14208267 204524 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 380 3 2 4 3.1 N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL72710 204524 None 0 Human Binding pIC50 = 4.7 4.7 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 380 3 2 4 3.1 N#Cc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
11062139 96675 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 703 8 5 6 5.5 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL26390 96675 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 703 8 5 6 5.5 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
11765552 113628 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
CHEMBL332263 113628 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
10740785 97309 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
CHEMBL269142 97309 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 419 4 3 5 4.5 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
44286379 100309 None 0 Human Binding pIC50 = 4.6 4.6 - 0
In vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortexIn vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortex
ChEMBL 852 21 6 9 3.3 CN(C(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00037a006
CHEMBL289284 100309 None 0 Human Binding pIC50 = 4.6 4.6 - 0
In vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortexIn vitro binding for half maximal inhibition of [125I]- cholecystokinin type B receptor in guinea pig cortex
ChEMBL 852 21 6 9 3.3 CN(C(=O)[C@H](CCCCNC(=O)/C=C/c1cccnc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00037a006
44303470 203263 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 479 8 2 5 4.5 Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL64623 203263 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 479 8 2 5 4.5 Cc1noc(C)c1CC(C)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
15670985 207089 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 490 9 3 5 3.2 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 10.1021/jm970373j
CHEMBL9195 207089 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 490 9 3 5 3.2 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C(=O)O)c2)c1 10.1021/jm970373j
10070677 161722 None 15 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL41361 161722 None 15 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
73354293 106554 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL314178 106554 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
73351319 168162 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 648 12 5 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL433148 168162 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 648 12 5 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCP(C)(=O)O)c1ccccc1 10.1021/jm00092a007
44354100 116767 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL337661 116767 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
73346732 169919 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL444113 169919 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
44354100 120809 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL355656 120809 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
44368567 168733 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL437039 168733 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44280740 100405 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL290122 100405 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 787 17 4 8 6.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
15673154 85993 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304155 85993 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 22 to 24
ChEMBL 650 12 6 5 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCP(=O)(O)O)c1ccccc1 10.1016/S0960-894X(00)80652-6
44376132 120244 None 0 Human Binding pIC50 = 7.6 7.6 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL352264 120244 None 0 Human Binding pIC50 = 7.6 7.6 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 494 6 3 6 3.9 CC(C)CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
10507109 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL321761 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
14843044 99647 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 511 4 1 3 6.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL284317 99647 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 511 4 1 3 6.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
44280116 99630 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL284183 99630 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 672 12 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44334354 4619 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 517 9 2 4 5.0 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102879 4619 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 517 9 2 4 5.0 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccc(F)cc3)CC2)c1 10.1016/0960-894X(95)00537-3
10252890 25621 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 444 5 2 5 3.7 COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 10.1021/jm00078a018
CHEMBL135167 25621 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 444 5 2 5 3.7 COc1cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc(OC)c1 10.1021/jm00078a018
44349023 16352 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 384 8 3 3 3.4 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
CHEMBL122922 16352 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 384 8 3 3 3.4 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
44349027 16824 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 438 7 3 5 2.9 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL124732 16824 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 438 7 3 5 2.9 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44349429 16835 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 406 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 10.1021/jm00079a003
CHEMBL124780 16835 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 406 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)C1CC2CCCCC2CN1 10.1021/jm00079a003
71456173 78482 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL2111826 78482 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
10531 1419 None 21 Mouse Binding pIC50 = 4.6 4.6 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
121 1419 None 21 Mouse Binding pIC50 = 4.6 4.6 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
888 1419 None 21 Mouse Binding pIC50 = 4.6 4.6 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
CHEMBL1732 1419 None 21 Mouse Binding pIC50 = 4.6 4.6 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
DB00320 1419 None 21 Mouse Binding pIC50 = 4.6 4.6 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O 10.1016/S0960-894X(00)80644-7
44348808 17933 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL125925 17933 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to CCK-B in rabbit gastric gland
ChEMBL 451 7 3 4 3.9 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44360340 32702 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 457 5 1 4 5.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 10.1021/jm00163a069
CHEMBL141354 32702 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 457 5 1 4 5.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)Cc1cccc2sccc12 10.1021/jm00163a069
CHEMBL411079 212860 None 0 Bovine Binding pIC50 = 5.6 5.6 - 0
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CSC(C)(C)[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
44396732 66891 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 545 7 2 6 4.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL186438 66891 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 545 7 2 6 4.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm0498755
10962743 78595 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
CHEMBL2112239 78595 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 6 3 5 4.4 Cc1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
11028319 79655 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 588 7 3 6 4.2 CN(C)c1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
CHEMBL2115130 79655 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 588 7 3 6 4.2 CN(C)c1ccc(N2C(=O)C[C@@H]3[C@@H](NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)OC(C)(C)C)CCCN3C2=O)cc1 10.1021/jm010813d
10078362 99789 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 689 8 5 6 5.2 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL285305 99789 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 689 8 5 6 5.2 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
90663996 106823 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144565 106823 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(OS(=O)(=O)O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10555571 104575 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL310466 104575 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10555571 104575 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL310466 104575 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 0 6 5.9 COc1ccc(N(C(=O)CN2C(=O)C(Cc3nn(C)c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
15667015 161852 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 10 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL414793 161852 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 10 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
9985099 117276 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 10.1021/jm00048a015
CHEMBL339515 117276 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2cc(Cl)ccc21 10.1021/jm00048a015
14208226 77826 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092871 77826 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44280029 96439 None 0 Human Binding pIC50 = 6.6 6.6 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL262125 96439 None 0 Human Binding pIC50 = 6.6 6.6 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44381550 165231 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 842 23 11 10 3.0 Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL422919 165231 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 842 23 11 10 3.0 Cc1ccccc1NC(=O)NCCCC[C@@H](CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
13822921 101626 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 431 3 1 5 4.3 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 10.1021/jm00396a028
CHEMBL298948 101626 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 431 3 1 5 4.3 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1ccc(Cl)cc1 10.1021/jm00396a028
14208275 67745 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907849 67745 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)[C@@H](NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208270 67750 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907853 67750 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
15167812 102194 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 3.6 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL302825 102194 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 3.6 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)[N+]([O-])=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
10078285 121505 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
CHEMBL358334 121505 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 680 12 3 6 5.7 C[Si](C)(C)CCOC(=O)C[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
44375064 52935 None 0 Mouse Binding pIC50 = 4.6 4.6 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])cc1 10.1016/s0960-894x(01)00044-0
CHEMBL159623 52935 None 0 Mouse Binding pIC50 = 4.6 4.6 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])cc1 10.1016/s0960-894x(01)00044-0
44375437 120065 None 0 Mouse Binding pIC50 = 4.6 4.6 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 506 11 6 7 2.3 O=C(O)CCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL350631 120065 None 0 Mouse Binding pIC50 = 4.6 4.6 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 506 11 6 7 2.3 O=C(O)CCNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44375447 165348 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.6 O=C(O)CCCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL423630 165348 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.6 O=C(O)CCCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
443375 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
443375 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
443375 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm020424z
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyInhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenously
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm020424z
443375 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00609-9
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00609-9
443375 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00163a069
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00163a069
155535579 172048 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471871 172048 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10790099 207272 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
CHEMBL9311 207272 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 459 7 3 7 4.3 COc1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
CHEMBL3143668 211177 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/0960-894X(96)00160-6
CHEMBL64605 215854 None 7 Human Binding pIC50 = 7.6 7.6 -4 3
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
CHEMBL64605 215854 None 7 Human Binding pIC50 = 7.6 7.6 -4 3
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
CHEMBL64605 215854 None 7 Human Binding pIC50 = 7.6 7.6 -4 3
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL64605 215854 None 7 Rat Binding pIC50 = 7.6 7.6 4 3
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050689o
CHEMBL64605 215854 None 7 Human Binding pIC50 = 7.6 7.6 -4 3
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663193 106609 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pigInhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pig
ChEMBL 739 17 8 9 1.7 CSCC[C@H](NC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm960509y
CHEMBL3142902 106609 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pigInhibitory activity against Cholecystokinin type B receptor using [125I]- BH-CCK-8 as radioligand in cortex tissue of guinea pig
ChEMBL 739 17 8 9 1.7 CSCC[C@H](NC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm960509y
44329055 207962 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 554 7 3 3 6.1 CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL97133 207962 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 554 7 3 3 6.1 CCc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
44280215 99828 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285586 99828 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL64605 215854 None 7 Human Binding pIC50 = 7.6 7.6 -4 3
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptorTested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
10507109 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
CHEMBL321761 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
10507109 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm950626d
CHEMBL321761 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm950626d
10626596 112779 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 555 7 1 4 5.6 O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 10.1021/jm970265x
CHEMBL330566 112779 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 555 7 1 4 5.6 O=C1C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc2N1CC(=O)N(c1ccccc1)C1CC1 10.1021/jm970265x
10507109 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/S0960-894X(97)00062-0
CHEMBL321761 109225 None 0 Human Binding pIC50 = 7.6 7.6 1 2
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/S0960-894X(97)00062-0
155519400 170432 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)n1cc([C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1 10.1021/acs.jmedchem.9b01936
CHEMBL4448553 170432 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)n1cc([C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1 10.1021/acs.jmedchem.9b01936
10649296 30774 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O 10.1021/jm970065l
CHEMBL139601 30774 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H]1CCCCC[C@@H]1O 10.1021/jm970065l
CHEMBL382051 212291 None 0 Human Binding pIC50 = 7.6 7.6 -131 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10325426 107599 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
CHEMBL318963 107599 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
155516160 170056 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4443016 170056 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1399 39 16 19 -2.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
73351327 82423 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL217424 82423 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
10073533 22552 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 472 7 3 5 3.5 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL132603 22552 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 472 7 3 5 3.5 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCC(=O)O)C2=O)c1 10.1021/jm00078a018
44376191 165323 None 0 Human Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL423472 165323 None 0 Human Binding pIC50 = 6.6 6.6 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 452 4 3 6 2.8 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3nn[nH]n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
19766168 59555 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL171722 59555 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 367 4 3 3 2.5 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL290444 210875 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44382487 165634 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 10 4 4 2.7 CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
CHEMBL424370 165634 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 518 10 4 4 2.7 CC(C)C[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
9988264 109721 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 888 22 9 8 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL322955 109721 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 888 22 9 8 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1C(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14208241 67749 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL1907852 67749 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
44381562 168612 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 827 22 10 9 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL436053 168612 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 827 22 10 9 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NNC[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL328422 211294 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1cccc(C)c1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
3960 2343 None 23 Human Binding pIC50 = 4.6 4.6 - 1
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
891 2343 None 23 Human Binding pIC50 = 4.6 4.6 - 1
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
CHEMBL24938 2343 None 23 Human Binding pIC50 = 4.6 4.6 - 1
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
13953692 101719 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 407 3 1 4 5.0 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 10.1021/jm00396a028
CHEMBL299538 101719 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 407 3 1 4 5.0 Fc1ccccc1C1=N[C@H](Cc2c[nH]c3ccccc23)c2nncn2-c2ccccc21 10.1021/jm00396a028
14208220 204528 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 365 6 1 5 1.5 CCOC(=O)CN1C(=O)C(NC=O)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL72738 204528 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 365 6 1 5 1.5 CCOC(=O)CN1C(=O)C(NC=O)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14208213 204606 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 362 3 3 3 2.7 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 10.1021/jm00120a002
CHEMBL73272 204606 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 362 3 3 3 2.7 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc[nH]1 10.1021/jm00120a002
5279119 204751 None 1 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.5 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00120a002
CHEMBL74515 204751 None 1 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.5 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00120a002
44366107 171717 None 0 Human Binding pIC50 = 4.6 4.6 - 0
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
CHEMBL446693 171717 None 0 Human Binding pIC50 = 4.6 4.6 - 0
In vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I](Nle)-HG-13 labeled gCholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
14154723 89518 None 0 Human Binding pIC50 = 4.6 4.6 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 14 7 6 3.6 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
CHEMBL2373213 89518 None 0 Human Binding pIC50 = 4.6 4.6 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 636 14 7 6 3.6 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
10348659 1802 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 604 8 2 5 5.4 O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 10.1021/jm950626d
866 1802 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 604 8 2 5 5.4 O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 10.1021/jm950626d
CHEMBL1184355 1802 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 604 8 2 5 5.4 O=C(NC1C(=O)N(c2ccccc2)c2c(N(C1=O)CC(=O)N(c1ccc(cc1)N(C)C)C(C)C)cccc2)Nc1ccccc1 10.1021/jm950626d
10841358 207418 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL94005 207418 None 0 Human Binding pIC50 = 5.6 5.6 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccc(F)cc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44280233 99206 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281490 99206 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44280028 99175 None 0 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL281318 99175 None 0 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44344743 163571 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 555 11 4 3 5.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm000937a
CHEMBL420320 163571 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 555 11 4 3 5.3 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)CC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm000937a
904 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
9915756 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL2111204 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL356898 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
904 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
9915756 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL2111204 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
CHEMBL356898 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1016/s0960-894x(98)00677-5
44210425 165292 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL423278 165292 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
10623881 207595 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 461 6 3 7 3.9 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
CHEMBL9501 207595 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 461 6 3 7 3.9 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
195737 123662 None 5 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL36206 123662 None 5 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
195737 123662 None 5 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36206 123662 None 5 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 423 6 1 4 5.4 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10252412 25770 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135289 25770 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ccccc3n2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
11753772 25989 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 455 6 2 4 3.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
CHEMBL135447 25989 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 455 6 2 4 3.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCN(C)C)C2=O)c1 10.1021/jm00078a018
10047411 28603 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
CHEMBL137684 28603 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
44356726 116780 None 8 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 3 2 5 3.4 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)OCO3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337733 116780 None 8 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 3 2 5 3.4 CN1C(=O)C(NC(=O)Nc2ccc3c(c2)OCO3)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10767360 205843 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 489 5 2 4 5.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 10.1021/jm9608523
CHEMBL83591 205843 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 489 5 2 4 5.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCC(C)(C)CCN2C)c2ccccc21 10.1021/jm9608523
44281020 116642 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33698 116642 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
15282007 168306 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL434126 168306 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3c[nH]cn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
5311205 13092 None 1 Human Binding pIC50 = 7.6 7.6 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL1190319 13092 None 1 Human Binding pIC50 = 7.6 7.6 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL540596 13092 None 1 Human Binding pIC50 = 7.6 7.6 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 445 2 2 4 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
904 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
9915756 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL2111204 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL356898 3024 None 10 Mouse Binding pIC50 = 6.6 6.6 - 1
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3142692 211130 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689727 106591 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142690 106591 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44381925 12850 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 538 11 2 4 4.5 CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1188615 12850 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 538 11 2 4 4.5 CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL536938 12850 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 538 11 2 4 4.5 CCN(CC)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1016/S0960-894X(00)80681-2
13809511 102292 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 512 6 2 5 4.1 CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL303386 102292 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 512 6 2 5 4.1 CN1C(=O)C(NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
10524785 207577 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 396 4 3 6 3.4 N#Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
CHEMBL9492 207577 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 396 4 3 6 3.4 N#Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1021/jm970373j
44283081 99869 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL2112071 99869 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
CHEMBL285880 99869 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 500 9 3 3 6.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(O)CCCc1ccccc1 10.1021/jm00086a017
10721792 167784 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 571 7 1 4 6.3 CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
CHEMBL430451 167784 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 571 7 1 4 6.3 CC(C)N(C(=O)CN1C(=O)C(C)(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
20063261 23123 None 14 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL133087 23123 None 14 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 412 3 2 3 4.3 Cc1cc(C)cc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280893 99234 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL281671 99234 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 13 4 5 5.0 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10625001 29176 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 7 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 10.1021/jm970065l
CHEMBL138190 29176 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 7 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(CO)CCCC1 10.1021/jm970065l
CHEMBL383458 212311 None 0 Human Binding pIC50 = 5.6 5.6 -4 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
73354294 106966 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 636 11 6 5 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
CHEMBL315055 106966 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 636 11 6 5 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CP(=O)(O)O)c1ccccc1 10.1021/jm00092a007
19756868 28415 None 2 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 409 3 2 4 3.5 CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137520 28415 None 2 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 409 3 2 4 3.5 CN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44281078 99741 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284975 99741 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL318475 211211 None 0 Rat Binding pIC50 = 7.6 7.6 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)NCC(=O)O 10.1016/S0960-894X(96)00546-X
44210425 165292 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL423278 165292 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 439 5 2 5 3.5 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)OC(C)(C)C)C2=O)c1 10.1016/S0960-894X(00)80683-6
10626598 51775 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 3 5 5.4 COC(=O)/C(=C/c1ccccc1)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(01)81250-6
CHEMBL158491 51775 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 555 8 3 5 5.4 COC(=O)/C(=C/c1ccccc1)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(01)81250-6
44333341 107784 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL319180 107784 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
443375 207604 None 45 Mouse Binding pIC50 = 6.6 6.6 2 5
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
CHEMBL9506 207604 None 45 Mouse Binding pIC50 = 6.6 6.6 2 5
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
5279169 26197 None 1 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 404 3 3 3 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00078a018
CHEMBL135715 26197 None 1 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 404 3 3 3 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00078a018
44381949 120722 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354802 120722 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
443375 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.6 6.6 -316 5
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
9985667 163359 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1021/jm000959x
CHEMBL419237 163359 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1021/jm000959x
9985667 163359 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
CHEMBL419237 163359 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptorInhibition of [3H]propionyl-CCK-8 binding to mouse cerebral cortex membrane cholecystokinin-B (CCK-B) receptor
ChEMBL 580 9 4 5 3.9 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2C[C@H](NC(=O)OCc3ccccc3)C(=O)N12 10.1016/s0960-894x(98)00677-5
14991568 100709 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292519 100709 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349298 16626 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 429 8 3 4 3.5 CC(C)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)cc1 10.1021/jm00079a003
CHEMBL124155 16626 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 429 8 3 4 3.5 CC(C)c1ccc(C(=O)NC(CCC(=O)O)C(=O)NN2CCC3(CCCC3)CC2)cc1 10.1021/jm00079a003
CHEMBL328422 211294 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1cccc(C)c1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
15104598 109781 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 481 13 2 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 10.1021/jm00116a002
CHEMBL323245 109781 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 481 13 2 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1 10.1021/jm00116a002
52949124 875 None 4 Human Binding pIC50 = 6.6 6.6 2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pIC50 = 6.6 6.6 2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pIC50 = 6.6 6.6 2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pIC50 = 6.6 6.6 2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
44396745 125036 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 125036 None 0 Rat Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
44329324 107315 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccc(Cl)cc3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL317366 107315 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccc(Cl)cc3)C2=O)c1 10.1016/S0960-894X(01)80832-5
14208225 67752 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907855 67752 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 3 3.9 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14843049 100477 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL290897 100477 None 0 Mouse Binding pIC50 = 7.6 7.6 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
44329519 108285 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 6 3 3 6.6 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C(F)(F)F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL319748 108285 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 6 3 3 6.6 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C(F)(F)F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
44329363 108702 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3Cl)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL320821 108702 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3Cl)C2=O)c1 10.1016/S0960-894X(01)80832-5
44329384 208329 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL99289 208329 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(C)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
10477146 78511 None 1 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2111920 78511 None 1 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
9887120 204124 None 4 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL70380 204124 None 4 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44211353 59051 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 552 9 2 5 3.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
CHEMBL169453 59051 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 552 9 2 5 3.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
15719750 78481 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL2111825 78481 None 0 Rat Binding pIC50 = 5.6 5.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
10156187 103104 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 10.1021/jm00120a002
CHEMBL307659 103104 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccccc1 10.1021/jm00120a002
44349277 114046 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 12 3 3 3.4 CCCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL332674 114046 None 0 Rat Binding pIC50 = 4.6 4.6 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 12 3 3 3.4 CCCCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
10531224 167999 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL432015 167999 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
10531224 167999 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
CHEMBL432015 167999 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 575 7 2 4 5.7 CC(C)N(C(=O)CN1C(=O)C(C)(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
44303526 203142 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 708 14 4 6 6.3 O=C(CCC(=O)OCc1ccccc1)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL64155 203142 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 708 14 4 6 6.3 O=C(CCC(=O)OCc1ccccc1)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
10528465 97048 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 4 7 4.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL267023 97048 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 4 7 4.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(=O)O)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
5311201 207393 None 35 Mouse Binding pIC50 = 7.5 7.5 -26 6
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
5311201 207393 None 35 Mouse Binding pIC50 = 7.5 7.5 -26 6
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 7.5 7.5 -26 6
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 7.5 7.5 -26 6
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
5311201 207393 None 35 Human Binding pIC50 = 7.5 7.5 -27 6
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
CHEMBL9387 207393 None 35 Human Binding pIC50 = 7.5 7.5 -27 6
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
11540160 71446 None 0 Dog Binding pIC50 = 7.5 7.5 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196133 71446 None 0 Dog Binding pIC50 = 7.5 7.5 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44300550 100894 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 376 3 2 3 3.7 Cc1cccc(NC(=O)NC2N=C(C3CCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL293786 100894 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 376 3 2 3 3.7 Cc1cccc(NC(=O)NC2N=C(C3CCC3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
44279811 96923 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL265987 96923 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44280372 99385 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282645 99385 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44403829 71450 None 0 Human Binding pIC50 = 6.5 6.5 - 1
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
CHEMBL196143 71450 None 0 Human Binding pIC50 = 6.5 6.5 - 1
Inhibitory concentration against Cholecystokinin B receptorInhibitory concentration against Cholecystokinin B receptor
ChEMBL 743 15 4 7 5.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(CC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm058225d
15689736 106598 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142702 106598 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14208241 67749 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL1907852 67749 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
14208221 79546 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2114102 79546 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 530 6 2 5 4.2 CN1C(=O)C(NC(=O)C(Cc2ccccc2)NC(=O)OC(C)(C)C)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
10454890 155140 None 1 Human Binding pIC50 = 5.5 5.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL40211 155140 None 1 Human Binding pIC50 = 5.5 5.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
90663986 106814 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 21 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144555 106814 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 21 8 8 3.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349326 16762 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1Cl 10.1021/jm00079a003
CHEMBL124378 16762 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1Cl 10.1021/jm00079a003
14208244 58866 None 0 Human Binding pIC50 = 5.5 5.5 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL168852 58866 None 0 Human Binding pIC50 = 5.5 5.5 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
14208215 103798 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 10.1021/jm00120a002
CHEMBL309017 103798 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 405 3 2 3 4.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cccc2ccccc12 10.1021/jm00120a002
14208234 204697 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 428 3 4 4 3.6 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 10.1021/jm00120a002
CHEMBL74066 204697 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 428 3 4 4 3.6 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2cc(O)ccc2[nH]1 10.1021/jm00120a002
44280179 103019 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30696 103019 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(CCc1ccccc1)C(=O)O 10.1021/jm950372w
44283500 139261 None 0 Mouse Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 9 3 5 4.8 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)OC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL37903 139261 None 0 Mouse Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 516 9 3 5 4.8 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)OC(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10817241 107120 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 591 8 1 5 5.6 COc1ccc(N(C(=O)CN2C(=O)C(Cc3[nH]nc4c3CCCC4)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL316077 107120 None 0 Human Binding pIC50 = 5.5 5.5 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 591 8 1 5 5.6 COc1ccc(N(C(=O)CN2C(=O)C(Cc3[nH]nc4c3CCCC4)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
10555804 111596 None 0 Human Binding pIC50 = 4.5 4.5 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 616 9 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL328285 111596 None 0 Human Binding pIC50 = 4.5 4.5 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 616 9 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44280895 168094 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL432679 168094 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 652 15 3 5 5.1 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL274661 210813 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
10409534 28237 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL137398 28237 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280252 99851 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285746 99851 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
11799359 29049 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCC[C@H]1O 10.1021/jm970065l
CHEMBL138084 29049 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCC[C@H]1O 10.1021/jm970065l
104929 2217 None 9 Human Binding pIC50 = 8.5 8.5 51 3
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
3477 2217 None 9 Human Binding pIC50 = 8.5 8.5 51 3
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
879 2217 None 9 Human Binding pIC50 = 8.5 8.5 51 3
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
CHEMBL289498 2217 None 9 Human Binding pIC50 = 8.5 8.5 51 3
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
15667016 86116 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 960 25 9 11 1.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL2310856 86116 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 960 25 9 11 1.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14888734 167844 None 0 Bovine Binding pIC50 = 8.5 8.5 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1012 29 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL430906 167844 None 0 Bovine Binding pIC50 = 8.5 8.5 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1012 29 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL5288951 194448 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity to human CCK2R expressed in human A-431 cellsBinding affinity to human CCK2R expressed in human A-431 cells
ChEMBL 1201 24 15 15 0.4 CCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)[C@H](NC(=O)c2ccc(NN)nc2)CCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.ejmech.2021.113538
10768071 9832 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 3 5 4.3 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
CHEMBL113988 9832 None 0 Rat Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brainInhibitory concentration against radioligand [125I]CCK-8 binding to gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 512 6 3 5 4.3 CC(C)(C)C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm960669+
10435698 141406 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL38404 141406 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL34554 211707 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
10435698 141406 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL38404 141406 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 490 6 2 5 4.2 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL59865 215814 None 0 Human Binding pIC50 = 8.5 8.5 - 1
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
56666696 64015 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1450 45 14 23 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1807149 64015 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1450 45 14 23 -2.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
15667013 107404 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 920 26 10 11 0.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL318010 107404 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 920 26 10 11 0.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14802510 115115 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 629 13 4 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL334346 115115 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 629 13 4 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
10051647 117283 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C(C)C 10.1021/jm00048a015
CHEMBL339547 117283 None 0 Human Binding pIC50 = 8.5 8.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(Cl)c1)C[C@@H]2C(C)C 10.1021/jm00048a015
71456223 78764 None 0 Bovine Binding pIC50 = 8.5 8.5 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1006 25 11 11 1.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL2112635 78764 None 0 Bovine Binding pIC50 = 8.5 8.5 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1006 25 11 11 1.8 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1CCCC[C@@H]1NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
44368298 121026 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 4 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL356599 121026 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 4 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](COC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
10481933 13294 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 524 5 2 5 3.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL1191818 13294 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 524 5 2 5 3.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL542967 13294 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 524 5 2 5 3.1 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
10673078 29085 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 502 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C#N 10.1021/jm970065l
CHEMBL138112 29085 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 502 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1C#N 10.1021/jm970065l
CHEMBL1806528 208972 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
54695534 3787 None 5 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of CCK-B receptor in rat cerebral cortexInhibition of CCK-B receptor in rat cerebral cortex
ChEMBL 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 10.1021/np500757w
910 3787 None 5 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of CCK-B receptor in rat cerebral cortexInhibition of CCK-B receptor in rat cerebral cortex
ChEMBL 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 10.1021/np500757w
CHEMBL3576924 3787 None 5 Rat Binding pIC50 = 8.4 8.4 - 0
Inhibition of CCK-B receptor in rat cerebral cortexInhibition of CCK-B receptor in rat cerebral cortex
ChEMBL 570 2 3 8 4.5 OC1C/C=C/CC(C)C2C(SCC2C(=O)C2=C(OC3(C(C/C=C/C=C/C1)C=C(C)C(C3)C)C2=O)O)C(=O)C(=O)O 10.1021/np500757w
104929 2217 None 9 Rat Binding pIC50 = 8.4 8.4 -165 3
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
3477 2217 None 9 Rat Binding pIC50 = 8.4 8.4 -165 3
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
879 2217 None 9 Rat Binding pIC50 = 8.4 8.4 -165 3
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
CHEMBL289498 2217 None 9 Rat Binding pIC50 = 8.4 8.4 -165 3
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
10347746 16799 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 558 6 3 3 6.2 CC1(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(Cl)c3)C[C@H](c3ccccc3)c3ccccc32)CCCCC1 10.1021/jm00048a015
CHEMBL124611 16799 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 558 6 3 3 6.2 CC1(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(Cl)c3)C[C@H](c3ccccc3)c3ccccc32)CCCCC1 10.1021/jm00048a015
10029582 27163 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136608 27163 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 517 7 2 4 4.5 CCN(CC)C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10004579 78514 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2111923 78514 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
43811299 116658 None 13 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337055 116658 None 13 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2cccc(C(F)(F)F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL408330 212703 None 0 Human Binding pIC50 = 8.4 8.4 -1 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44373740 119890 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL349079 119890 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
44368521 46292 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 576 12 5 5 4.6 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL153557 46292 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 576 12 5 5 4.6 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL2372294 210210 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@H]1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 10.1021/jm00001a019
CHEMBL34853 211713 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44333048 169255 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
CHEMBL441165 169255 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1032 28 10 11 3.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1021/jm00072a024
44331865 4272 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 538 12 3 4 3.9 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CC(=O)N1CCC[C@H]1C(=O)O)CC1CCCCC1 10.1016/S0960-894X(96)00546-X
CHEMBL100604 4272 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 538 12 3 4 3.9 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CC(=O)N1CCC[C@H]1C(=O)O)CC1CCCCC1 10.1016/S0960-894X(96)00546-X
10391769 17736 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 514 6 3 4 4.7 COc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
CHEMBL125863 17736 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 514 6 3 4 4.7 COc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)c1 10.1021/jm00048a015
443375 207604 None 45 Human Binding pIC50 = 6.5 6.5 -316 5
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.5 6.5 -316 5
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL37983 212264 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
443375 207604 None 45 Human Binding pIC50 = 6.5 6.5 -316 5
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL9506 207604 None 45 Human Binding pIC50 = 6.5 6.5 -316 5
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
10432393 100344 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
CHEMBL289533 100344 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
CHEMBL431116 213621 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00388a002
10341724 78513 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2111922 78513 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 414 4 2 4 3.7 COc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
15637183 119237 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 3 5 4.1 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CN2CCCC2)C1=O 10.1021/jm00078a018
CHEMBL343513 119237 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 531 7 3 5 4.1 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CN2CCCC2)C1=O 10.1021/jm00078a018
14991570 202813 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 943 22 9 11 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL62345 202813 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 943 22 9 11 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349383 16765 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL124396 16765 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
44349028 117220 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 437 7 3 4 3.5 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL339453 117220 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 437 7 3 4 3.5 O=C(O)CCC(NC(=O)c1ccc2ccccc2c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL285995 99890 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 741 16 6 11 4.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCNCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44334704 4616 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 499 9 2 4 4.8 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL102862 4616 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 499 9 2 4 4.8 Cc1cccc(NC(=O)N[C@H](COCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44332066 4513 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL102184 4513 None 0 Rat Binding pIC50 = 6.5 6.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCCC1C(=O)O 10.1016/S0960-894X(96)00546-X
15689724 106596 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(C(F)(F)F)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142696 106596 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(C(F)(F)F)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689726 106592 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142691 106592 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1cccc(Cl)c1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
10079315 167866 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 859 21 9 7 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL431065 167866 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 859 21 9 7 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
13822924 101942 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 427 4 1 6 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
CHEMBL301172 101942 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 427 4 1 6 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
13605417 207566 None 4 Mouse Binding pIC50 = 5.5 5.5 - 1
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80687-3
CHEMBL9485 207566 None 4 Mouse Binding pIC50 = 5.5 5.5 - 1
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80687-3
10453004 26123 None 9 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 390 3 2 3 3.5 CN1C(=O)C(NC(=O)NC2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135618 26123 None 9 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 390 3 2 3 3.5 CN1C(=O)C(NC(=O)NC2CCCCC2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
14991576 102212 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 21 9 9 3.4 COc1ccc2[nH]c(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)cc2c1 10.1021/jm00089a010
CHEMBL302911 102212 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 866 21 9 9 3.4 COc1ccc2[nH]c(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)cc2c1 10.1021/jm00089a010
14991535 106793 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144534 106793 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663978 106802 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c(OC)c1 10.1021/jm00089a010
CHEMBL3144542 106802 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c(OC)c1 10.1021/jm00089a010
14991582 201247 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 871 21 7 8 4.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL60385 201247 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 871 21 7 8 4.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
3960 2343 None 23 Rat Binding pIC50 = 5.5 5.5 - 1
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
891 2343 None 23 Rat Binding pIC50 = 5.5 5.5 - 1
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
CHEMBL24938 2343 None 23 Rat Binding pIC50 = 5.5 5.5 - 1
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCCC 10.1021/jm00079a003
71449051 78483 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL2111827 78483 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CC[C@H](NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44349077 117839 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
CHEMBL340263 117839 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
14208250 168048 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL432334 168048 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
9865694 204174 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00120a002
CHEMBL70728 204174 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 3 2 2 5.2 O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1Cc1c[nH]c2ccccc12 10.1021/jm00120a002
44366097 121966 None 0 Human Binding pIC50 = 4.5 4.5 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NC(Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL359141 121966 None 0 Human Binding pIC50 = 4.5 4.5 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NC(Cc1ccccc1)C(N)=O 10.1021/jm00123a003
15614750 119321 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 3 3 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
CHEMBL344154 119321 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 426 4 3 3 3.9 O=C(NCC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00163a069
10509945 89382 None 0 Human Binding pIC50 = 5.5 5.5 - 2
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL2369816 89382 None 0 Human Binding pIC50 = 5.5 5.5 - 2
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
46235271 73646 None 2 Human Binding pIC50 = 6.5 6.5 -2 2
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pIC50 = 6.5 6.5 -2 2
Displacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R V3.28T, S3.29T mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
44349254 16831 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL124751 16831 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
155531277 171629 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4465747 171629 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1821 72 18 23 2.1 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10056421 106625 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3143025 106625 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
44333278 4753 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 464 5 2 6 2.6 CCCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL103791 4753 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 464 5 2 6 2.6 CCCN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
443375 207604 None 45 Mouse Binding pIC50 = 7.5 7.5 2 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00105a062
CHEMBL9506 207604 None 45 Mouse Binding pIC50 = 7.5 7.5 2 5
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00105a062
443375 207604 None 45 Mouse Binding pIC50 = 7.5 7.5 2 5
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80687-3
CHEMBL9506 207604 None 45 Mouse Binding pIC50 = 7.5 7.5 2 5
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80687-3
14843046 99843 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL285707 99843 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
443375 207604 None 45 Mouse Binding pIC50 = 7.5 7.5 2 5
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00057a005
CHEMBL9506 207604 None 45 Mouse Binding pIC50 = 7.5 7.5 2 5
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00057a005
44329487 108511 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(F)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL319986 108511 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)C[C@H](c3cccc(F)c3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
132190 120335 None 18 Mouse Binding pIC50 = 7.5 7.5 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 O=C1NN(C(=O)Nc2ccc(Br)cc2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL352949 120335 None 18 Mouse Binding pIC50 = 7.5 7.5 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 O=C1NN(C(=O)Nc2ccc(Br)cc2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
11801335 119533 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 579 7 2 4 5.5 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm950626d
CHEMBL345786 119533 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 579 7 2 4 5.5 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm950626d
CHEMBL1172251 208581 None 0 Human Binding pIC50 = 7.5 7.5 -2 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
10649606 49614 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL156605 49614 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Displacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]BDZ1 from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
132916 3159 None 16 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 438 3 2 3 3.8 O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 10.1016/S0960-894X(96)00609-9
874 3159 None 16 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 438 3 2 3 3.8 O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 10.1016/S0960-894X(96)00609-9
CHEMBL300072 3159 None 16 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 438 3 2 3 3.8 O=C(c1cc2c([nH]1)cccc2)N[C@H]1N=C(c2ccccc2F)c2c3N(C1=O)CCc3ccc2 10.1016/S0960-894X(96)00609-9
9977368 116246 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2cccnc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL335865 116246 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2cccnc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44370451 50788 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL157658 50788 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 435 15 3 4 4.3 CCCCCN(CCCCC)C(=O)[C@H](CCC(=O)O)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
9896825 102975 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30656 102975 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 742 14 6 10 2.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
19766170 59155 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169931 59155 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
15689732 106613 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142906 106613 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689732 106613 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3142906 106613 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 870 21 9 10 3.0 COC(=O)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
15104602 9450 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
CHEMBL111808 9450 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
44349024 17129 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
CHEMBL125551 17129 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1021/jm00079a003
14208266 104378 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 371 3 3 4 2.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 10.1021/jm00120a002
CHEMBL310250 104378 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 371 3 3 4 2.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(O)cc1 10.1021/jm00120a002
44375212 165394 None 0 Mouse Binding pIC50 = 4.5 4.5 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL423803 165394 None 0 Mouse Binding pIC50 = 4.5 4.5 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(N/C(S)=N\Nc2ccc(S(=O)(=O)NCCc3c[nH]c4ccccc34)cc2[N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44359614 31866 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 8 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)CNC1CCCCC1 10.1021/jm970065l
CHEMBL140701 31866 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 8 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)CNC1CCCCC1 10.1021/jm970065l
10507561 120999 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 585 7 2 4 5.4 CC(C)N(C(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
CHEMBL356408 120999 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptorCompound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor
ChEMBL 585 7 2 4 5.4 CC(C)N(C(=O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm9601664
44365359 121286 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 546 12 3 5 4.5 COc1ccc(N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc2ccccc2)c2ccccc2)C(C)C)cc1 10.1016/S0960-894X(97)00062-0
CHEMBL357983 121286 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptorTested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor
ChEMBL 546 12 3 5 4.5 COc1ccc(N(C(=O)CN(C(=O)[C@@H](CCC(=O)O)NC(=O)Nc2ccccc2)c2ccccc2)C(C)C)cc1 10.1016/S0960-894X(97)00062-0
15177358 99069 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.6 O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL280502 99069 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 515 9 4 4 4.6 O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10789434 206634 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 444 6 3 8 3.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
CHEMBL8921 206634 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 444 6 3 8 3.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
10413618 202789 None 0 Mouse Binding pIC50 = 7.5 7.5 - 1
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/s0960-894x(00)00198-0
CHEMBL62205 202789 None 0 Mouse Binding pIC50 = 7.5 7.5 - 1
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/s0960-894x(00)00198-0
15667018 157780 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 998 27 10 11 2.5 CCCC[C@H](NC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL408286 157780 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 998 27 10 11 2.5 CCCC[C@H](NC(=O)c1ccc2cc(OS(=O)(=O)O)ccc2c1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
9983419 109385 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL321946 109385 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
10030027 17944 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)[C@@H](c1ccccc1)C[C@@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N2CC(=O)NC(C)(C)C 10.1021/jm00048a015
CHEMBL126002 17944 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)[C@@H](c1ccccc1)C[C@@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N2CC(=O)NC(C)(C)C 10.1021/jm00048a015
73346731 81544 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL216079 81544 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
10413618 202789 None 0 Mouse Binding pIC50 = 7.5 7.5 - 1
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL62205 202789 None 0 Mouse Binding pIC50 = 7.5 7.5 - 1
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(97)00356-9
10452597 26924 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 2 3 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136408 26924 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 2 3 3.6 CN1C(=O)C(NC(=O)Nc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280371 103026 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30701 103026 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
10413618 202789 None 0 Mouse Binding pIC50 = 7.5 7.5 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
CHEMBL62205 202789 None 0 Mouse Binding pIC50 = 7.5 7.5 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
44356697 25620 None 1 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 2 5 3.4 COC(=O)Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL135166 25620 None 1 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 2 5 3.4 COC(=O)Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280399 103093 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30756 103093 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 603 10 4 5 4.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm950372w
44280371 103026 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30701 103026 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 815 19 4 8 6.6 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
15689739 106590 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142683 106590 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc2ccccc2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15167816 204494 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
CHEMBL72546 204494 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00078a018
9821357 17277 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 9 3 3 3.2 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL125703 17277 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 382 9 3 3 3.2 CC(C)(C)CCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
10001488 164924 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 4 3 3 3.6 O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL422411 164924 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 4 3 3 3.6 O=C(Cc1c[nH]c2ccccc12)NC1N=C(c2ccccc2)c2ccccc2NC1=O 10.1021/jm00120a002
15200522 120466 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354126 120466 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 422 4 2 3 3.7 CN1C(=O)C(NC(=O)Cc2c[nH]c3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
10719200 169500 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 471 6 3 3 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)Nc1ccccc1 10.1021/jm970065l
CHEMBL443284 169500 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 471 6 3 3 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)Nc1ccccc1 10.1021/jm970065l
10528637 97302 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
CHEMBL269123 97302 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2)c1 10.1021/jm970373j
10838356 207642 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
CHEMBL9524 207642 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 477 6 3 7 4.4 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)c1 10.1021/jm970373j
14843052 99724 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL284853 99724 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 486 5 1 4 5.5 CN(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
9978270 78810 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 3 4 3.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112749 78810 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 3 4 3.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(N)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10323690 100496 None 0 Mouse Binding pIC50 = 6.5 6.5 - 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL2114401 100496 None 0 Mouse Binding pIC50 = 6.5 6.5 - 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL291033 100496 None 0 Mouse Binding pIC50 = 6.5 6.5 - 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
44382698 59470 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(OS(=O)(=O)O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL171375 59470 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(OS(=O)(=O)O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
14843041 125040 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36436 125040 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44280029 96439 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL262125 96439 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL3142687 211128 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44381758 11728 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 565 9 2 5 3.4 CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1181391 11728 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 565 9 2 5 3.4 CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL169440 11728 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 565 9 2 5 3.4 CN1CCN(CCNC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
15104611 109255 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 3 4 6.0 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2ccccc2n1 10.1021/jm00116a002
CHEMBL321811 109255 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 3 4 6.0 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2ccccc2n1 10.1021/jm00116a002
14208313 67738 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL1907842 67738 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44349391 117048 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 9 3 3 4.2 CCC1(CC)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
CHEMBL339115 117048 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 422 9 3 3 4.2 CCC1(CC)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
44280112 99593 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
CHEMBL283924 99593 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 11 3 5 5.4 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)N1CCCc2ccccc21 10.1021/jm950372w
10091467 116703 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccccn2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL337285 116703 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 385 3 2 4 3.0 CN1C(=O)C(NC(=O)Nc2ccccn2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
14802539 76550 None 1 Mouse Binding pIC50 = 7.5 7.5 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL2062144 76550 None 1 Mouse Binding pIC50 = 7.5 7.5 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(01)80769-1
14843038 138206 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 138206 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10369442 108545 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 521 7 3 5 3.6 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL320154 108545 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 521 7 3 5 3.6 Cc1cccc(NC(=O)N[C@H](COC(=O)N2CCCC2)C(=O)N2CCC(C(=O)Nc3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44332067 4390 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL101352 4390 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 546 13 3 4 3.5 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCc1ccccc1)CC(=O)N1CCC[C@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL100609 208450 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL100609 208450 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
44280114 5108 None 0 Human Binding pIC50 = 5.5 5.5 - 2
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
CHEMBL105618 5108 None 0 Human Binding pIC50 = 5.5 5.5 - 2
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
15167800 32717 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 412 4 3 3 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1cc2ccccc2[nH]1 10.1021/jm00163a069
CHEMBL141365 32717 None 0 Human Binding pIC50 = 4.5 4.5 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 412 4 3 3 4.4 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1cc2ccccc2[nH]1 10.1021/jm00163a069
44209151 59432 None 1 Human Binding pIC50 = 4.5 4.5 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL171108 59432 None 1 Human Binding pIC50 = 4.5 4.5 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 301 3 2 2 3.8 O=C(Cc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44303237 100805 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL293178 100805 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 590 10 4 8 4.3 CC(Cc1ccc(-c2csnn2)cc1)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44280177 99487 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283204 99487 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 11 3 4 5.3 O=C(O)C[C@H](Cc1ccccc1)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
10604135 78837 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 637 8 3 5 5.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12)OC1C2CC3CC(C2)CC1C3 10.1021/jm991078x
CHEMBL2112823 78837 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 637 8 3 5 5.1 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12)OC1C2CC3CC(C2)CC1C3 10.1021/jm991078x
44396765 67373 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 594 8 2 5 5.4 O=C(OC1C2CC3CC(C2)CC1C3)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
CHEMBL188667 67373 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 594 8 2 5 5.4 O=C(OC1C2CC3CC(C2)CC1C3)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
44327735 107277 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 627 15 3 4 7.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCCCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317062 107277 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 627 15 3 4 7.1 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCCCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
10413579 117081 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1021/jm00048a015
CHEMBL339260 117081 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3)c3ccccc3N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1021/jm00048a015
10047172 78813 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 410 4 2 3 4.3 C=Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2112752 78813 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 410 4 2 3 4.3 C=Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44280252 99851 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285746 99851 None 0 Mouse Binding pIC50 = 7.5 7.5 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44331993 158207 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 609 5 1 5 5.5 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1CC(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL408803 158207 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 609 5 1 5 5.5 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1CC(=O)O 10.1016/S0960-894X(96)00546-X
10369806 116818 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@@H](NC(=O)Nc1cccc(Cl)c1)C[C@H]2c1ccccc1 10.1021/jm00048a015
CHEMBL337937 116818 None 0 Human Binding pIC50 = 7.5 7.5 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 5 3 3 5.6 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@@H](NC(=O)Nc1cccc(Cl)c1)C[C@H]2c1ccccc1 10.1021/jm00048a015
44272229 98743 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80644-7
CHEMBL278032 98743 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80644-7
44272229 98743 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80253-5
CHEMBL278032 98743 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 635 15 6 6 3.5 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80253-5
44280213 101616 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29888 101616 None 0 Mouse Binding pIC50 = 6.5 6.5 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 685 12 5 9 3.7 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL318570 211213 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44209154 59092 None 1 Human Binding pIC50 = 4.5 4.5 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL169675 59092 None 1 Human Binding pIC50 = 4.5 4.5 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44283030 99653 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 629 12 3 7 5.4 COC(=O)CCC(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
CHEMBL284361 99653 None 0 Mouse Binding pIC50 = 6.5 6.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 629 12 3 7 5.4 COC(=O)CCC(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
44280091 168436 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL434967 168436 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44385777 128809 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
CHEMBL366943 128809 None 0 Rat Binding pIC50 = 5.5 5.5 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
44283177 100302 None 0 Mouse Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 655 16 2 5 7.6 CCOC(=O)CCCCCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL289239 100302 None 0 Mouse Binding pIC50 = 5.5 5.5 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 655 16 2 5 7.6 CCOC(=O)CCCCCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44349262 116950 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 9 3 3 2.5 CC(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL338607 116950 None 0 Rat Binding pIC50 = 4.5 4.5 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 9 3 3 2.5 CC(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44279957 99209 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL281507 99209 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 553 10 3 4 4.7 CC(C)CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10598999 207661 None 0 Mouse Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 4 3 5 5.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc3ccccc23)c1 10.1021/jm970373j
CHEMBL9532 207661 None 0 Mouse Binding pIC50 = 5.5 5.5 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 435 4 3 5 5.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc3ccccc23)c1 10.1021/jm970373j
44368567 168733 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL437039 168733 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 495 9 4 4 4.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1F)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10765241 103978 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
CHEMBL309299 103978 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
44329352 111435 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
CHEMBL327496 111435 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1ccccc1[C@H]1C[C@@H](NC(=O)Nc2cccc(F)c2)C(=O)N(CC(=O)NC(C)(C)C)[C@@H](c2ccccc2)C1 10.1016/S0960-894X(01)80832-5
44280741 156560 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL406844 156560 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 759 15 4 8 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL316925 211194 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N1CCC[C@@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
44327457 107336 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317577 107336 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
14843038 138206 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 138206 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10462874 98834 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/s0960-894x(00)00198-0
CHEMBL278780 98834 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 766 16 6 5 7.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCCCNC(=O)Nc1ccccc1Cl 10.1016/s0960-894x(00)00198-0
44381829 168526 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@H](CNN[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(00)80680-0
CHEMBL435465 168526 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@H](CNN[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(00)80680-0
44375062 55680 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
CHEMBL162184 55680 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1cccc(NS(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
44348835 16819 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 938 25 11 11 0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL124719 16819 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 938 25 11 11 0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
14991581 102435 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 22 8 9 3.2 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)CCc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL303994 102435 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 22 8 9 3.2 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)CCc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349314 16565 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
CHEMBL123852 16565 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 402 8 3 3 3.5 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1cc(Cl)cc(Cl)c1 10.1021/jm00079a003
44280266 98775 None 0 Mouse Binding pIC50 = 5.4 5.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL278217 98775 None 0 Mouse Binding pIC50 = 5.4 5.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
14208260 102117 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.3 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
CHEMBL302359 102117 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 423 3 2 3 4.3 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
44283086 119332 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 482 8 2 2 7.2 CC(/C=C/CCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL34422 119332 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 482 8 2 2 7.2 CC(/C=C/CCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44349152 18560 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)cc1 10.1021/jm00079a003
CHEMBL127604 18560 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 354 10 3 3 2.6 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)cc1 10.1021/jm00079a003
10675328 111503 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 617 9 1 6 5.7 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL327815 111503 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 617 9 1 6 5.7 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)(OC)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
44283031 99987 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 2 5 6.4 CCOC(=O)CCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286664 99987 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 613 13 2 5 6.4 CCOC(=O)CCC(=O)N(CCc1ccccc1)CC(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL414345 213122 None 7 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0498755
19766167 59233 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL170293 59233 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
14843051 99881 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL285940 99881 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
14843050 163141 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CC(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL417876 163141 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 485 5 1 3 6.5 CC(C)c1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL285995 99890 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 741 16 6 11 4.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCCNCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
11802426 100281 None 0 Rat Binding pIC50 = 7.4 7.4 50 2
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL289021 100281 None 0 Rat Binding pIC50 = 7.4 7.4 50 2
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
90663141 106602 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 618 14 6 6 0.6 CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C1=O 10.1016/S0960-894X(96)00546-X
CHEMBL3142755 106602 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 618 14 6 6 0.6 CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N1CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C1=O 10.1016/S0960-894X(96)00546-X
6956374 2403 None 5 Mouse Binding pIC50 = 6.4 6.4 - 1
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
902 2403 None 5 Mouse Binding pIC50 = 6.4 6.4 - 1
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
CHEMBL117281 2403 None 5 Mouse Binding pIC50 = 6.4 6.4 - 1
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1021/jm000937a
14843029 139232 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 443 4 1 3 5.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Br)c1 10.1021/jm00108a040
CHEMBL37887 139232 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 443 4 1 3 5.4 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Br)c1 10.1021/jm00108a040
44279808 99139 None 0 Human Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281082 99139 None 0 Human Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44332281 4736 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 455 12 3 3 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)O 10.1016/S0960-894X(96)00546-X
CHEMBL103713 4736 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 455 12 3 3 4.3 CCCC[C@H](NC(=O)Cc1c[nH]c2ccccc12)C(=O)N(CCC1CCCCC1)CC(=O)O 10.1016/S0960-894X(96)00546-X
6956374 2403 None 5 Mouse Binding pIC50 = 6.4 6.4 - 1
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
902 2403 None 5 Mouse Binding pIC50 = 6.4 6.4 - 1
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL117281 2403 None 5 Mouse Binding pIC50 = 6.4 6.4 - 1
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 6.5
ChEMBL 435 3 2 2 4.9 Brc1ccc(cc1)NC(=O)N1NC(=O)[C@@H]([C@H]1c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80684-8
15689737 106597 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142701 106597 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 862 20 9 8 4.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC/N=C(\S)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14208194 163434 None 2 Mouse Binding pIC50 = 5.4 5.4 - 2
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
CHEMBL419764 163434 None 2 Mouse Binding pIC50 = 5.4 5.4 - 2
Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexHalf maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000937a
14208317 67688 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907667 67688 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208194 163434 None 2 Human Binding pIC50 = 5.4 5.4 - 2
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL419764 163434 None 2 Human Binding pIC50 = 5.4 5.4 - 2
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80684-8
CHEMBL354363 211729 None 0 Mouse Binding pIC50 = 4.4 4.4 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
155524770 170936 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1641 66 14 19 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4455361 170936 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1641 66 14 19 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44342477 110521 None 0 Rat Binding pIC50 = 5.4 5.4 - 1
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL325070 110521 None 0 Rat Binding pIC50 = 5.4 5.4 - 1
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1016/0960-894X(96)00160-6
CHEMBL160753 208807 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
10745561 17833 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
CHEMBL125897 17833 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 566 8 4 5 3.5 O=C(N[C@@H]1C[C@H]2c3[nH]c4ccccc4c3C[C@H](C(=O)N[C@H](Cc3ccccc3)C(=O)O)N2C1=O)OCc1ccccc1 10.1021/jm000959x
20190197 31517 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 421 4 1 3 4.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccc(Cl)cc1 10.1021/jm00163a069
CHEMBL140365 31517 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 421 4 1 3 4.6 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)c1ccc(Cl)cc1 10.1021/jm00163a069
11799462 162014 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL415965 162014 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
14843038 138206 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37699 138206 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 473 5 1 4 5.4 COc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44329306 109646 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 8 3 3 7.0 CCc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL322381 109646 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 8 3 3 7.0 CCc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC3(C)CCCCC3)C2=O)c1 10.1016/S0960-894X(01)80832-5
13953716 101595 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 442 3 2 5 4.9 Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00396a028
CHEMBL298705 101595 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 442 3 2 5 4.9 Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00396a028
13953715 194674 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 428 3 2 5 4.6 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21 10.1021/jm00396a028
CHEMBL53234 194674 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 428 3 2 5 4.6 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21 10.1021/jm00396a028
10048986 27552 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL136919 27552 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)O)C2=O)c1 10.1021/jm00078a018
44280495 99124 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL280980 99124 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL100609 208450 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
44381578 120507 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL354512 120507 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)CNN[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
44381915 59054 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 454 15 2 3 5.4 CCCCCN(CCCCC)C(=O)[C@@H](CCCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
CHEMBL169466 59054 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 454 15 2 3 5.4 CCCCCN(CCCCC)C(=O)[C@@H](CCCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80681-2
14208208 169477 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 4 2 3 3.8 O=C(/C=C/c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL443009 169477 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 399 4 2 3 3.8 O=C(/C=C/c1ccccc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
44349185 16529 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
CHEMBL123720 16529 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
CHEMBL169178 208835 None 0 Mouse Binding pIC50 = 4.4 4.4 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N1CC(=O)N[C@@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
14208315 67735 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 495 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907839 67735 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 495 3 1 3 3.9 CN1C(=O)[C@@H](NC(=O)c2ccccc2I)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
10361419 26451 None 13 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 364 2 2 3 2.9 CN1C(=O)C(NC(=O)NC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135988 26451 None 13 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 364 2 2 3 2.9 CN1C(=O)C(NC(=O)NC(C)(C)C)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
145982146 166576 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 415 3 2 6 3.8 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Cl)c1 10.1039/C7MD00171A
CHEMBL4279998 166576 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 415 3 2 6 3.8 O=C1Nc2ccccc2/C1=N/Nc1nc2ccccc2c(=O)n1-c1cccc(Cl)c1 10.1039/C7MD00171A
CHEMBL333299 211389 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
44280729 168227 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
CHEMBL433621 168227 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 644 12 4 5 4.3 O=C(CC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)NCc1ccccc1 10.1021/jm950372w
19766221 118887 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 569 7 3 5 5.2 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00163a069
CHEMBL342256 118887 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 569 7 3 5 5.2 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00163a069
10793952 102779 None 0 Rat Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL30524 102779 None 0 Rat Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44280163 104371 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL31018 104371 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
5311201 207393 None 35 Rat Binding pIC50 = 7.4 7.4 -234 6
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
CHEMBL9387 207393 None 35 Rat Binding pIC50 = 7.4 7.4 -234 6
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
10553146 116711 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.7 CC1CCCCC1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL337310 116711 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.7 CC1CCCCC1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL433398 213637 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL None None None CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(=O)O 10.1016/S0960-894X(96)00546-X
10722372 119579 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(=O)O)cc1 10.1021/jm950626d
CHEMBL346179 119579 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(C(=O)O)cc1 10.1021/jm950626d
11497371 70628 None 0 Dog Binding pIC50 = 7.4 7.4 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL195007 70628 None 0 Dog Binding pIC50 = 7.4 7.4 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
14208228 103105 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 470 5 3 4 3.3 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL307661 103105 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 470 5 3 4 3.3 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208303 204689 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL73946 204689 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)C(NC(=O)c2cccc(I)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44280507 113494 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
CHEMBL33200 113494 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 573 9 3 4 5.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(C(=O)O)c1ccccc1 10.1021/jm950372w
44334278 4698 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 515 9 2 4 5.5 Cc1cccc(NC(=O)N[C@H](CSCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL103457 4698 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 515 9 2 4 5.5 Cc1cccc(NC(=O)N[C@H](CSCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL407530 212665 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
14208202 204640 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 4 2 4 4.5 O=C(Cc1cccc2sccc12)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL73563 204640 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 4 2 4 4.5 O=C(Cc1cccc2sccc12)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
44334434 5089 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 483 8 2 3 5.2 Cc1cccc(NC(=O)N[C@H](CCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105527 5089 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 483 8 2 3 5.2 Cc1cccc(NC(=O)N[C@H](CCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL171310 208845 None 0 Mouse Binding pIC50 = 4.4 4.4 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CC(=O)N[C@H](Cc2ccccc2)C1 10.1016/S0960-894X(01)80253-5
14720389 165081 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL422701 165081 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 373 10 3 3 2.8 CCCN(CCC)C(=O)[C@H](CCC(=O)O)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
44283029 100052 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 627 11 3 7 5.2 COC(=O)/C=C/C(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
CHEMBL287079 100052 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 627 11 3 7 5.2 COC(=O)/C=C/C(=O)N[C@H](COC(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1 10.1021/jm00086a017
CHEMBL2369373 209602 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
44408524 155703 None 0 Human Binding pIC50 = 5.4 5.4 -158 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL405192 155703 None 0 Human Binding pIC50 = 5.4 5.4 -158 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
9985100 114500 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2cccc(Cl)c2)c2ccccc21 10.1021/jm00048a015
CHEMBL333541 114500 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2cccc(Cl)c2)c2ccccc21 10.1021/jm00048a015
44368522 119479 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 574 11 5 5 4.4 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
CHEMBL345303 119479 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 574 11 5 5 4.4 C[C@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00057a005
5311201 207393 None 35 Human Binding pIC50 = 8.4 8.4 -27 6
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.4 8.4 -27 6
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL432671 168093 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 784 15 7 12 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCNC(=O)CC(=O)NCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
5311201 207393 None 35 Human Binding pIC50 = 8.4 8.4 -27 6
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.4 8.4 -27 6
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
5311201 207393 None 35 Human Binding pIC50 = 8.4 8.4 -27 6
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.4 8.4 -27 6
Inhibitory concentration against gastrin receptorInhibitory concentration against gastrin receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm058225d
101823779 1395 None 35 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
16162108 1395 None 35 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
8408 1395 None 35 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
CHEMBL4451154 1395 None 35 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL None None None None 10.1021/acs.jmedchem.8b01558
10075014 162979 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL417521 162979 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 508 6 2 5 4.4 CCOC(=O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
44300862 157870 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 9 4 6 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)Cc3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL408392 157870 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 9 4 6 5.2 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)Cc3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
14802520 116291 None 1 Mouse Binding pIC50 = 8.4 8.4 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL335914 116291 None 1 Mouse Binding pIC50 = 8.4 8.4 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
14802520 120358 None 1 Mouse Binding pIC50 = 8.4 8.4 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL353157 120358 None 1 Mouse Binding pIC50 = 8.4 8.4 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
10074366 120596 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 120596 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 120596 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44368612 121994 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 612 13 5 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL359361 121994 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 612 13 5 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00057a005
136242438 78624 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 6 7 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1n[nH]c(=O)[nH]1)c1ccccc1 10.1021/jm00092a007
CHEMBL2112333 78624 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 671 12 6 7 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1n[nH]c(=O)[nH]1)c1ccccc1 10.1021/jm00092a007
10481751 113089 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL331315 113089 None 0 Human Binding pIC50 = 8.4 8.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL438773 213795 None 0 Bovine Binding pIC50 = 8.4 8.4 - 0
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
CHEMBL2370122 209785 None 0 Bovine Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL267849 210732 None 0 Bovine Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10030203 25888 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 540 6 2 6 2.8 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL135371 25888 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 540 6 2 6 2.8 COc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1021/jm00078a018
15281997 48500 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 486 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3nccn3C)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL155627 48500 None 0 Rat Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 486 5 2 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3nccn3C)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
14802528 118463 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 642 14 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
CHEMBL341281 118463 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex Cholecystokinin type B receptor
ChEMBL 642 14 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CNC(=O)CCCC(=O)O)Cc1ccccc1 10.1021/jm00105a062
10720403 119428 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCCC[C@H]1O 10.1021/jm970065l
CHEMBL344882 119428 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 507 6 4 4 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H]1CCCCC[C@H]1O 10.1021/jm970065l
CHEMBL336381 211581 None 0 Human Binding pIC50 = 8.3 8.3 97 5
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44300864 201917 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 681 8 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL60754 201917 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 681 8 4 6 5.1 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
56663037 63932 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1802 69 14 31 -2.7 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
CHEMBL1806529 63932 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]CCK from gastrin receptor isolated from human tumor tissuesDisplacement of [125I]CCK from gastrin receptor isolated from human tumor tissues
ChEMBL 1802 69 14 31 -2.7 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm101279a
44356710 116609 None 8 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 426 4 2 4 3.9 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL336765 116609 None 8 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 426 4 2 4 3.9 CC(=O)c1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2369769 209683 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexConcentration producing half-maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(94)85022-4
44333624 4584 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 462 5 2 5 3.1 CCCN1C(=O)C(NC(=O)Nc2cccc(CC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL102633 4584 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 462 5 2 5 3.1 CCCN1C(=O)C(NC(=O)Nc2cccc(CC)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
19018661 28481 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(CC(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137567 28481 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 5 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(CC(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10430103 78512 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 3 3 3.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3NC2=O)c1 10.1021/jm00078a018
CHEMBL2111921 78512 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 384 3 3 3 3.9 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3NC2=O)c1 10.1021/jm00078a018
44280269 99215 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL281559 99215 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44329520 107409 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1ccc(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C)c3)C[C@H](c3ccccc3C)C[C@@H]2c2ccccc2)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL318024 107409 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1ccc(NC(=O)CN2C(=O)[C@H](NC(=O)Nc3cccc(C)c3)C[C@H](c3ccccc3C)C[C@@H]2c2ccccc2)cc1 10.1016/S0960-894X(01)80832-5
44327421 155705 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
CHEMBL405208 155705 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 3 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1016/S0960-894X(01)80769-1
44349082 17773 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL125874 17773 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
44349074 117034 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 426 7 4 4 2.8 O=C(O)CCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL339041 117034 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 426 7 4 4 2.8 O=C(O)CCC(NC(=O)c1cc2ccccc2[nH]1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44348887 118087 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 469 7 3 4 4.0 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL340630 118087 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 469 7 3 4 4.0 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44280215 99828 None 0 Mouse Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL285586 99828 None 0 Mouse Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 756 15 6 10 3.3 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCSCc4csc(N=C(N)N)n4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44281204 99848 None 0 Mouse Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL285719 99848 None 0 Mouse Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44381949 120722 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL354802 120722 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL290818 210877 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
14208192 102994 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
CHEMBL306760 102994 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 394 3 3 3 3.7 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
44375446 56280 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 644 12 5 7 5.6 O=C(O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
CHEMBL162947 56280 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 644 12 5 7 5.6 O=C(O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccc(N/N=C(/S)NCCc3c[nH]c4ccccc34)c([N+](=O)[O-])c2)c1 10.1016/s0960-894x(01)00044-0
90663979 106807 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1OC 10.1021/jm00089a010
CHEMBL3144548 106807 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 883 23 8 10 3.3 COc1ccc(/C=C\C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1OC 10.1021/jm00089a010
44281005 116729 None 0 Mouse Binding pIC50 = 5.4 5.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL33743 116729 None 0 Mouse Binding pIC50 = 5.4 5.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 787 17 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00249-1
14208264 102107 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 411 3 2 3 4.5 CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL302282 102107 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 411 3 2 3 4.5 CC(C)(C)c1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
14208243 204415 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL72073 204415 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
44283132 120799 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 485 9 3 3 5.9 CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL35555 120799 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 485 9 3 3 5.9 CC(CNCCc1ccccc1)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
10717652 106155 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
CHEMBL313653 106155 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 433 5 3 4 3.8 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@@H]2CCCCN2)c2ccccc21 10.1021/jm9608523
10070678 120753 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL355092 120753 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
15637181 28438 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 533 9 3 5 4.4 CCN(CC)C[C@H](O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137535 28438 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 533 9 3 5 4.4 CCN(CC)C[C@H](O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44334176 5068 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 527 9 2 5 4.7 Cc1cccc(NC(=O)N[C@H](CC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL105404 5068 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 527 9 2 5 4.7 Cc1cccc(NC(=O)N[C@H](CC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
10070678 120753 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL355092 120753 None 1 Human Binding pIC50 = 6.4 6.4 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
15104624 9998 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 2 4 5.7 CCCCCN(CCCCC)C(=O)[C@@H](CC1C(=O)Nc2ccccc21)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL114913 9998 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 514 13 2 4 5.7 CCCCCN(CCCCC)C(=O)[C@@H](CC1C(=O)Nc2ccccc21)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
44370497 165191 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 453 8 3 3 4.6 O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 10.1021/jm00164a020
CHEMBL422873 165191 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 453 8 3 3 4.6 O=C(O)CC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N(C1CCCCC1)C1CCCCC1 10.1021/jm00164a020
10010723 4911 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 836 20 8 7 3.1 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL104598 4911 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 836 20 8 7 3.1 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(F)(F)F)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
73345199 141743 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL385918 141743 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniInhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
57393204 67687 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
CHEMBL1907666 67687 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
14208313 67738 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL1907842 67738 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
9914964 9629 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 530 13 4 5 5.7 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2cccc(O)c2n1 10.1021/jm00116a002
CHEMBL112682 9629 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 530 13 4 5 5.7 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(O)c2cccc(O)c2n1 10.1021/jm00116a002
44381719 58868 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 558 12 3 5 3.4 O=C(CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
CHEMBL168855 58868 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 558 12 3 5 3.4 O=C(CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2)NCCN1CCOCC1 10.1016/S0960-894X(00)80681-2
10463229 119807 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 840 20 9 8 3.8 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)Nc1ccccc1C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00031a013
CHEMBL348346 119807 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 840 20 9 8 3.8 CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)Nc1ccccc1C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00031a013
44303722 100847 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 807 20 5 11 4.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
CHEMBL293456 100847 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 807 20 5 11 4.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)OC(C)(C)C 10.1016/S0960-894X(01)81005-2
10056407 120146 None 0 Human Binding pIC50 = 6.4 6.4 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 854 20 7 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
CHEMBL351364 120146 None 0 Human Binding pIC50 = 6.4 6.4 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 854 20 7 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
44280234 102283 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
CHEMBL30335 102283 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.7 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1ccccc1 10.1021/jm950372w
10762723 97028 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 386 4 3 6 3.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
CHEMBL266819 97028 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 386 4 3 6 3.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccnc2)c1 10.1021/jm970373j
71452652 78502 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2111884 78502 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
10346551 114634 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL333813 114634 None 0 Human Binding pIC50 = 7.4 7.4 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 518 5 3 3 5.3 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
14802538 96687 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL263969 96687 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
14802538 96687 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm970065l
CHEMBL263969 96687 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm970065l
136056456 205741 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 421 5 1 4 5.8 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL82690 205741 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 421 5 1 4 5.8 CC(C)Oc1cccc(-n2c(/C=C/c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
44370393 119642 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 492 14 2 3 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL346784 119642 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 492 14 2 3 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCCC1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
44280714 100031 None 0 Mouse Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286908 100031 None 0 Mouse Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
108187 925 None 37 Mouse Binding pIC50 = 5.4 5.4 -9 5
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
873 925 None 37 Mouse Binding pIC50 = 5.4 5.4 -9 5
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
CHEMBL2062154 925 None 37 Mouse Binding pIC50 = 5.4 5.4 -9 5
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
CHEMBL287735 925 None 37 Mouse Binding pIC50 = 5.4 5.4 -9 5
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00086a017
14991567 199798 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL59404 199798 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 847 20 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280973 99865 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
CHEMBL285857 99865 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 704 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCC2CCCCC2C1 10.1021/jm950372w
44361604 31475 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 621 8 3 4 4.9 O=C(N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CC3CC(CC(C3)C1)C2 10.1021/jm991078x
CHEMBL140320 31475 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 621 8 3 4 4.9 O=C(N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C12CC3CC(CC(C3)C1)C2 10.1021/jm991078x
10392870 29098 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 552 7 2 5 5.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)OCc2ccccc2)C1=O 10.1021/jm00078a018
CHEMBL138122 29098 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 552 7 2 5 5.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)OCc2ccccc2)C1=O 10.1021/jm00078a018
9845465 118857 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 5 3 4 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCO)C2=O)c1 10.1021/jm00078a018
CHEMBL342201 118857 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 5 3 4 3.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCO)C2=O)c1 10.1021/jm00078a018
44280314 169692 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL443781 169692 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
14208272 67737 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907841 67737 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 455 3 1 3 4.4 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44280495 99124 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL280980 99124 None 0 Mouse Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 641 10 5 8 3.7 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44334438 109253 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 513 9 2 4 5.2 Cc1cccc(NC(=O)N[C@@H](C(=O)N2CCC(C(=O)c3ccccc3)CC2)[C@@H](C)OCc2ccccc2)c1 10.1016/0960-894X(95)00537-3
CHEMBL321800 109253 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 513 9 2 4 5.2 Cc1cccc(NC(=O)N[C@@H](C(=O)N2CCC(C(=O)c3ccccc3)CC2)[C@@H](C)OCc2ccccc2)c1 10.1016/0960-894X(95)00537-3
14208308 67741 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907845 67741 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccccc2I)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14991544 106803 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 22 10 10 2.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144543 106803 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 857 22 10 10 2.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663991 106818 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 868 22 8 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144560 106818 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 868 22 8 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc([N+](=O)[O-])cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44370406 49885 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 529 16 2 4 6.6 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL156814 49885 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 529 16 2 4 6.6 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCc1ccccc1)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
15719707 78485 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL2111829 78485 None 0 Rat Binding pIC50 = 4.4 4.4 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 368 8 3 3 2.9 CC(C)(C)CCNC(=O)[C@H](CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44280387 119766 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
CHEMBL34797 119766 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 559 8 3 4 5.4 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)Nc1ccccc1C(=O)O 10.1021/jm950372w
10550527 207375 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.2 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9377 207375 None 0 Mouse Binding pIC50 = 7.4 7.4 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 429 6 3 6 4.2 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44280090 99534 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL283460 99534 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 11 4 4 5.7 O=C(O)CC(Cc1c[nH]c2ccccc12)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
44281205 114816 None 0 Mouse Binding pIC50 = 7.4 7.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33412 114816 None 0 Mouse Binding pIC50 = 7.4 7.4 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44280028 99175 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL281318 99175 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 768 17 6 9 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44381852 59041 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
CHEMBL169398 59041 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
10601173 31191 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCCC1 10.1021/jm970065l
CHEMBL140073 31191 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 6 3 3 5.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCCC1 10.1021/jm970065l
10649606 49614 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL156605 49614 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 519 6 3 4 4.5 O=C(CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)Nc1ccccc1 10.1016/j.bmcl.2015.03.051
57390472 67753 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
CHEMBL1907856 67753 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 431 5 1 4 3.3 COc1cccc(CC(=O)N[C@@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)c1 10.1021/jm00120a002
44329383 108289 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL319749 108289 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 6 3 3 5.5 Cc1cccc(NC(=O)N[C@H]2C[C@H](c3ccccc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL107694 208488 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL156559 208803 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
44381480 59453 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 825 20 7 8 4.6 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL171227 59453 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 825 20 7 8 4.6 Cc1ccccc1NC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1016/S0960-894X(00)80680-0
CHEMBL156559 208803 None 0 Human Binding pIC50 = 5.4 5.4 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
44375073 54937 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccccc1NS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL161426 54937 None 0 Mouse Binding pIC50 = 5.4 5.4 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 554 10 6 7 4.0 O=C(O)c1ccccc1NS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44370446 119599 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 467 15 2 4 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL346361 119599 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 467 15 2 4 5.4 CCCCCN(CCCCC)C(=O)C(CCC(=O)OCC)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL156559 208803 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44303510 12031 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 617 17 6 9 1.5 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
CHEMBL1183386 12031 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 617 17 6 9 1.5 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
CHEMBL294329 12031 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)Compound was tested for its binding affinity towards Cholecystokinin type B receptor in cortical membranes (CNS)
ChEMBL 617 17 6 9 1.5 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)[C@@H](Cc1ccccc1)C(N)=O)n1nnnc1[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN 10.1016/S0960-894X(01)81005-2
44329305 109223 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 610 7 3 3 7.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C(C)(C)C)C(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL321752 109223 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 610 7 3 3 7.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C(C)(C)C)C(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
155540394 172934 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4516794 172934 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1820 69 17 23 2.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155566319 175738 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4583158 175738 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1850 71 16 23 3.2 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
14843041 125040 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36436 125040 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 471 5 1 3 6.0 CCc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14843043 130142 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL36779 130142 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 489 5 1 4 6.1 CSc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44356645 25773 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 419 3 2 4 3.7 CN1C(=O)C(NC(=O)Nc2ccc(Cl)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135290 25773 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 419 3 2 4 3.7 CN1C(=O)C(NC(=O)Nc2ccc(Cl)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10455302 27997 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccc([N+](=O)[O-])cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137240 27997 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 429 4 2 5 3.6 CN1C(=O)C(NC(=O)Nc2ccc([N+](=O)[O-])cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280501 100021 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
CHEMBL286847 100021 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.6 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NC1CCCc2ccccc21 10.1021/jm950372w
19766160 58507 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL168386 58507 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
44356619 118794 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 415 4 2 5 3.1 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cn1 10.1021/jm00078a018
CHEMBL342142 118794 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 415 4 2 5 3.1 COc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cn1 10.1021/jm00078a018
44281004 100077 None 0 Mouse Binding pIC50 = 6.3 6.3 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
CHEMBL287295 100077 None 0 Mouse Binding pIC50 = 6.3 6.3 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 15 4 8 6.4 Cc1cccc(NC(=O)N[C@@H]2N=C(c3cccc(OC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00249-1
10373344 166632 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 844 21 8 7 3.8 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL428103 166632 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 844 21 8 7 3.8 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
10476766 102998 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 3 3 3.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
CHEMBL306806 102998 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 3 3 3.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 10.1021/jm00120a002
14208312 77820 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2092865 77820 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44375711 53441 None 0 Mouse Binding pIC50 = 4.3 4.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 492 10 6 7 1.9 O=C(O)CNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL160092 53441 None 0 Mouse Binding pIC50 = 4.3 4.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 492 10 6 7 1.9 O=C(O)CNS(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
14843037 138621 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 429 5 1 4 5.3 COc1cccc(-n2c(CCc3c[nH]c4ccc(Cl)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37758 138621 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 429 5 1 4 5.3 COc1cccc(-n2c(CCc3c[nH]c4ccc(Cl)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
90663995 106822 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144564 106822 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 23 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10033396 108587 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 824 20 8 7 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL320405 108587 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 824 20 8 7 3.5 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL156559 208803 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14991579 100988 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 862 21 9 8 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL294304 100988 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 862 21 9 8 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
10555164 112752 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 575 7 1 4 6.0 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm970265x
CHEMBL330521 112752 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 575 7 1 4 6.0 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc(F)cc1 10.1021/jm970265x
44369350 120071 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL350683 120071 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 495 6 2 5 4.5 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00557-A
10323690 100496 None 0 Mouse Binding pIC50 = 7.3 7.3 - 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL2114401 100496 None 0 Mouse Binding pIC50 = 7.3 7.3 - 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
CHEMBL291033 100496 None 0 Mouse Binding pIC50 = 7.3 7.3 - 2
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00105a062
10102593 141503 None 2 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 141503 None 2 Rat Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
10413618 202789 None 0 Mouse Binding pIC50 = 7.3 7.3 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL62205 202789 None 0 Mouse Binding pIC50 = 7.3 7.3 - 1
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1016/S0960-894X(01)80769-1
10073082 25135 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL134750 25135 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10075297 115504 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)c1 10.1021/jm00078a018
CHEMBL335239 115504 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 518 6 3 5 4.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)Nc3ccncc3)C2=O)c1 10.1021/jm00078a018
10323690 100496 None 0 Mouse Binding pIC50 = 7.3 7.3 - 2
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL2114401 100496 None 0 Mouse Binding pIC50 = 7.3 7.3 - 2
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL291033 100496 None 0 Mouse Binding pIC50 = 7.3 7.3 - 2
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00057a005
10413618 202789 None 0 Mouse Binding pIC50 = 7.3 7.3 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
CHEMBL62205 202789 None 0 Mouse Binding pIC50 = 7.3 7.3 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm970065l
44336539 5142 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
CHEMBL105775 5142 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 563 7 2 5 4.6 COc1ccc(N(C)C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)cc1 10.1016/j.bmcl.2015.03.051
44210427 120766 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL355319 120766 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 459 4 2 4 4.7 CC(C)(C)OC(=O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
14843033 136953 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL37439 136953 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
14991564 106801 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 827 21 9 9 2.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144541 106801 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 827 21 9 9 2.5 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280180 102631 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30430 102631 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 655 11 5 8 3.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
10010890 108735 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 874 22 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL320858 108735 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 874 22 8 8 4.3 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL319439 211216 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None CNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44458049 99095 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 363 4 3 3 2.0 O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
CHEMBL280733 99095 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 363 4 3 3 2.0 O=C(N[C@@H]1C(=O)N(c2ccccc2)C[C@@H]1C(=O)O)c1cc2ccccc2[nH]1 10.1016/S0960-894X(00)80224-3
13953709 162336 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 409 4 1 6 4.0 O=C(NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
CHEMBL416483 162336 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 409 4 1 6 4.0 O=C(NC1N=C(c2ccccc2)c2ccccc2-n2cnnc21)OCc1ccccc1 10.1021/jm00396a028
14991538 106824 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144566 106824 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 921 24 9 11 2.4 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44334259 4470 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 8 2 3 4.8 CCCC[C@@H](NC(=O)Nc1cccc(C)c1)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
CHEMBL101803 4470 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 8 2 3 4.8 CCCC[C@@H](NC(=O)Nc1cccc(C)c1)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
44349327 16895 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 334 8 3 3 2.2 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
CHEMBL125083 16895 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 334 8 3 3 2.2 CC(C)(C)CCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
155564421 175266 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1770 69 16 21 3.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4572516 175266 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1770 69 16 21 3.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44368368 121075 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 481 8 3 3 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL357027 121075 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 481 8 3 3 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)NCCc1ccccc1 10.1021/jm00057a005
44212546 99926 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL286228 99926 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 626 10 4 4 5.3 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280407 119709 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL34743 119709 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 4.7 CN(Cc1ccccc1)C(=O)[C@@H](CC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
9870046 26346 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 5 3 6 3.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(Cc2nn[nH]n2)C1=O 10.1021/jm00078a018
CHEMBL135901 26346 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 486 5 3 6 3.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(Cc2nn[nH]n2)C1=O 10.1021/jm00078a018
CHEMBL99786 215927 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00173a006
10603571 168518 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 594 9 3 6 4.0 COC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
CHEMBL435407 168518 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 594 9 3 6 4.0 COC(=O)C[C@@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
10838675 207211 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 487 8 3 8 4.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OCC)c2)c1 10.1021/jm970373j
CHEMBL9267 207211 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 487 8 3 8 4.1 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OCC)c2)c1 10.1021/jm970373j
10719721 207428 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 7 3 8 3.8 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
CHEMBL9406 207428 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 486 7 3 8 3.8 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
14888738 98352 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 984 28 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(-c2nn[nH]n2)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL275167 98352 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 984 28 10 13 0.8 CSCC[C@H](NC(=O)CCc1ccc(-c2nn[nH]n2)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44348902 155760 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)ccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL405805 155760 None 0 Bovine Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 1000 24 11 11 2.3 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(NC(=O)[C@H](Cc2ccc(S(=O)(=O)O)cc2)NC(=O)O)ccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
10389657 24656 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL134340 24656 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 3 2 3 4.4 CN1C(=O)C(NC(=O)Nc2cccc(Br)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
9987406 96366 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 717 8 5 6 5.9 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL26167 96366 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 717 8 5 6 5.9 O=C(O)c1cc(NC(=O)C2Cc3ccccc3CCCCN2C(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
44301016 157974 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 673 7 4 6 4.5 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)C(F)(F)F)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL408490 157974 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 673 7 4 6 4.5 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)C(F)(F)F)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
5311201 207393 None 35 Mouse Binding pIC50 = 8.3 8.3 -26 6
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00092a007
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 8.3 8.3 -26 6
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00092a007
5311201 207393 None 35 Mouse Binding pIC50 = 8.3 8.3 -26 6
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00105a062
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 8.3 8.3 -26 6
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00105a062
5311201 207393 None 35 Mouse Binding pIC50 = 8.3 8.3 -26 6
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00057a005
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 8.3 8.3 -26 6
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00057a005
CHEMBL2386885 210395 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCCC(=O)NCCCC(CCCNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
104929 2217 None 9 Human Binding pIC50 = 8.3 8.3 51 3
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
3477 2217 None 9 Human Binding pIC50 = 8.3 8.3 51 3
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
879 2217 None 9 Human Binding pIC50 = 8.3 8.3 51 3
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
CHEMBL289498 2217 None 9 Human Binding pIC50 = 8.3 8.3 51 3
Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)Displacement of [125I]-gastrin17 from CCK-B receptor (unknown origin)
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1039/C7MD00171A
10770670 92491 None 0 Mouse Binding pIC50 = 8.3 8.3 301 2
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL2067959 92491 None 0 Mouse Binding pIC50 = 8.3 8.3 301 2
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
CHEMBL24313 92491 None 0 Mouse Binding pIC50 = 8.3 8.3 301 2
Evaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenatesEvaluated for Cholecystokinin type B receptor antagonistic activity in which 20 pM [125I]BH-CCK-8S was used to label CCKB/gastrin binding sites in mouse cortical homogenates
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/S0960-894X(97)00211-4
5311201 207393 None 35 Human Binding pIC50 = 8.3 8.3 -27 6
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.3 8.3 -27 6
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in guinea pig brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
10319892 59089 None 2 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL169661 59089 None 2 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
10319892 59089 None 2 Human Binding pIC50 = 8.3 8.3 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL169661 59089 None 2 Human Binding pIC50 = 8.3 8.3 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
4627 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
864 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
9833444 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
CHEMBL1121 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
DB09142 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL None None None None 10.1021/jm991078x
51353551 18132 None 16 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
CHEMBL1269257 18132 None 16 Human Binding pIC50 = 8.3 8.3 - 0
Displacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cellsDisplacement of [125I]CCK from CCK2R (unknown origin) expressed in CHO cells
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmcl.2015.03.051
4627 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
864 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
9833444 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
CHEMBL1121 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
DB09142 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL None None None None 10.1021/jm0498755
4627 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
864 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
9833444 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
CHEMBL1121 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
DB09142 821 None 50 Rat Binding pIC50 = 8.3 8.3 1 5
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL None None None None 10.1021/jm010898i
444998 209317 None 30 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm010813d
CHEMBL216166 209317 None 30 Rat Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm010813d
11757086 25674 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 541 10 2 6 4.2 CCN(CC)CC(=O)OCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135218 25674 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 541 10 2 6 4.2 CCN(CC)CC(=O)OCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
9960964 85991 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304152 85991 None 0 Mouse Binding pIC50 = 8.3 8.3 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 3.0 to 8.1
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1016/S0960-894X(00)80652-6
10341247 120088 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 405 2 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(N3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL350853 120088 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 405 2 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(N3CCCCC3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
10695559 59035 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 467 5 4 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL169362 59035 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 467 5 4 7 2.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(Nc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
44356799 26062 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135538 26062 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 4.7 CN1C(=O)C(NC(=O)Nc2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
155557285 174516 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4555341 174516 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1779 74 19 22 1.6 CCCC[C@H](NC(=O)[C@H](CNC(=O)CCCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10789229 98378 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 440 6 3 7 3.8 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL275307 98378 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 440 6 3 7 3.8 CCOc1cccc(-n2c(NNC(=O)Nc3cccc(C#N)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10837829 98562 None 1 Mouse Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(Cl)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL276627 98562 None 1 Mouse Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 463 6 3 6 5.0 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(Cl)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10029145 98168 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 504 7 2 5 4.6 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL273919 98168 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 504 7 2 5 4.6 CCOC(=O)CCN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44357068 164880 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 3 4 3.6 CN1C(=O)C(NC(=O)NCc2cccc(C(C)(C)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL422102 164880 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 456 5 3 4 3.6 CN1C(=O)C(NC(=O)NCc2cccc(C(C)(C)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10601831 96502 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
CHEMBL262569 96502 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 511 6 3 7 5.0 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
CHEMBL287753 210865 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
10552615 29311 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 477 6 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1 10.1021/jm970065l
CHEMBL138311 29311 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 477 6 3 3 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1 10.1021/jm970065l
44451577 95783 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Binding affinity to mouse CCK2 receptorBinding affinity to mouse CCK2 receptor
ChEMBL 546 6 2 5 2.1 Cc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL258630 95783 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Binding affinity to mouse CCK2 receptorBinding affinity to mouse CCK2 receptor
ChEMBL 546 6 2 5 2.1 Cc1cccc(NC(=O)NC2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
10483574 6204 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 591 8 2 5 5.3 COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm950626d
CHEMBL108130 6204 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cellsConcentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 591 8 2 5 5.3 COc1ccc(N(C(=O)CN2C(=O)C(NC(=O)Nc3ccccc3)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm950626d
21121108 81997 None 2 Rat Binding pIC50 = 6.3 6.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL216527 81997 None 2 Rat Binding pIC50 = 6.3 6.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL431116 213621 None 0 Human Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00123a003
CHEMBL386811 212391 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
44356620 28659 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 5 2.6 CN1C(=O)C(NC(=O)Nc2ccc(N)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137748 28659 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 400 3 3 5 2.6 CN1C(=O)C(NC(=O)Nc2ccc(N)nc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
11744065 78811 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.6 CC(=O)Oc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL2112750 78811 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.6 CC(=O)Oc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
178143 16850 None 2 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 440 14 2 3 5.0 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
CHEMBL124832 16850 None 2 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 440 14 2 3 5.0 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc2ccccc2c1 10.1021/jm00079a003
44349083 118061 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL340463 118061 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1ccc(Cl)c(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44210426 59116 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169807 59116 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44381593 120470 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 854 23 9 10 3.3 CN(C(=O)[C@H](CC(=O)O)NNC[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL354171 120470 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 854 23 9 10 3.3 CN(C(=O)[C@H](CC(=O)O)NNC[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
14208249 204630 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 387 3 2 3 3.7 Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL73510 204630 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 387 3 2 3 3.7 Cc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
14444006 41412 None 0 Human Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL149034 41412 None 0 Human Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)CC(CC(=O)NC(CC(=O)O)C(=O)NCCc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
90663980 106808 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144549 106808 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)cc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
90663981 106809 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144550 106809 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280224 104782 None 0 Mouse Binding pIC50 = 5.3 5.3 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL31090 104782 None 0 Mouse Binding pIC50 = 5.3 5.3 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 757 16 4 7 5.8 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44381749 12896 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 540 14 1 4 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
CHEMBL1188959 12896 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 540 14 1 4 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
CHEMBL537834 12896 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 540 14 1 4 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)N1CCN(C)CC1)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
14444025 106679 None 0 Human Binding pIC50 = 4.3 4.3 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1 10.1021/jm00123a003
CHEMBL3143400 106679 None 0 Human Binding pIC50 = 4.3 4.3 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CC(N)=O)Cc1ccccc1 10.1021/jm00123a003
44366188 165314 None 0 Human Binding pIC50 = 4.3 4.3 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
CHEMBL423405 165314 None 0 Human Binding pIC50 = 4.3 4.3 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 692 17 7 7 2.7 CC(C)CC(CC(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm00123a003
44306744 102664 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 782 20 9 7 2.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL304524 102664 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 782 20 9 7 2.5 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL319438 211215 None 0 Human Binding pIC50 = 5.3 5.3 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00017a022
44306887 102059 None 0 Human Binding pIC50 = 4.3 4.3 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL302027 102059 None 0 Human Binding pIC50 = 4.3 4.3 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 816 18 9 7 3.4 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1cccc(NC(=O)Nc2ccccc2C)c1)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
44349150 17623 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 340 9 3 3 2.2 CCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL125829 17623 None 0 Rat Binding pIC50 = 4.3 4.3 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 340 9 3 3 2.2 CCCCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
10651635 165270 None 0 Rat Binding pIC50 = 6.3 6.3 - 1
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL423119 165270 None 0 Rat Binding pIC50 = 6.3 6.3 - 1
Inhibitory activity against CCK-B receptorInhibitory activity against CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44375448 119886 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 4.2 O=C(O)CCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL349046 119886 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 4.2 O=C(O)CCN(Cc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
90663993 106820 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 901 21 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Br)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144562 106820 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 901 21 8 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(Br)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44368594 121049 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 447 8 3 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1)C(=O)NCCc1ccccc1 10.1021/jm00057a005
CHEMBL356810 121049 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 447 8 3 3 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1)C(=O)NCCc1ccccc1 10.1021/jm00057a005
10318742 25005 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL134657 25005 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccncc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
10071645 27992 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ncccc3c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137238 27992 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 435 3 2 4 4.2 CN1C(=O)C(NC(=O)Nc2ccc3ncccc3c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44331849 111487 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 551 3 0 4 5.7 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1CCc2ccccc2C1 10.1016/S0960-894X(96)00546-X
CHEMBL327727 111487 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain.
ChEMBL 551 3 0 4 5.7 CC(C)(C)OC(=O)N1c2ccccc2C[C@@H]1C(=O)N1[C@H](c2ccccc2)CC[C@@H]1C(=O)N1CCc2ccccc2C1 10.1016/S0960-894X(96)00546-X
10350551 108453 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 838 21 8 7 3.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL319913 108453 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 838 21 8 7 3.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL317477 211201 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None COC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
10320031 77823 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092868 77823 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14991577 163242 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 870 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL418500 163242 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 870 20 9 8 4.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(Cl)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
5279123 204539 None 1 Human Binding pIC50 = 4.3 4.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
CHEMBL72841 204539 None 1 Human Binding pIC50 = 4.3 4.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccccc1Cl 10.1021/jm00120a002
11707484 133137 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
CHEMBL370355 133137 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
10627173 206540 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL88602 206540 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10627173 206540 None 0 Human Binding pIC50 = 5.3 5.3 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL88602 206540 None 0 Human Binding pIC50 = 5.3 5.3 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 586 8 1 4 6.5 COc1ccc(N(C(=O)CN2C(=O)C(Cc3c[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
10392523 207942 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL96970 207942 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44381463 96824 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL265147 96824 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL2370119 209783 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)C(Cc1cccc(CC(=O)O)c1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44334345 163852 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 504 8 2 4 4.0 Cc1cccc(NC(=O)N[C@H](CCC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL420658 163852 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 504 8 2 4 4.0 Cc1cccc(NC(=O)N[C@H](CCC(=O)N2CCCC2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208297 67744 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907848 67744 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 513 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(I)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
90663983 106811 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144552 106811 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 891 21 8 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44327420 111584 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 10 2 5 5.3 COC(=O)CN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL328213 111584 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 10 2 5 5.3 COC(=O)CN(CCc1ccccc1)C(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
155553269 174125 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1818 68 15 22 3.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4545970 174125 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1818 68 15 22 3.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N1CCC[C@@H]1C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44280694 100278 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL289018 100278 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 5 4.4 CSCCC(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10649303 207454 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9422 207454 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.Compound was evaluated for functional activity on Cholecystokinin type B receptor (CCK-B) receptor carried out on guinea pig stomach cells.
ChEMBL 507 6 3 6 5.1 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
44373701 52489 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 541 8 4 4 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N/C(=C\c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81250-6
CHEMBL159138 52489 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 541 8 4 4 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N/C(=C\c1ccccc1)C(=O)O 10.1016/S0960-894X(01)81250-6
CHEMBL2079549 209190 None 0 Bovine Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(CC(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
10046672 116080 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2cccc(F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL335666 116080 None 2 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2cccc(F)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10813333 105351 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 5 2 4 4.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2C)c2ccccc21 10.1021/jm9608523
CHEMBL311638 105351 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 447 5 2 4 4.2 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C([C@H]2CCCCN2C)c2ccccc21 10.1021/jm9608523
10070678 120753 None 1 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
CHEMBL355092 120753 None 1 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00121a004
44382562 59098 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL169710 59098 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 662 13 5 5 5.8 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccc(O)cc1)NCCc1ccccc1 10.1016/S0960-894X(00)80687-3
44280117 102049 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL30195 102049 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 672 12 3 6 5.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
10070678 120753 None 1 Human Binding pIC50 = 6.3 6.3 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL355092 120753 None 1 Human Binding pIC50 = 6.3 6.3 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
44210428 59112 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL169794 59112 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 485 4 2 4 3.1 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3cccc4ccccc34)CCc3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
14208254 204504 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 4 2 4 3.4 COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL72599 204504 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 4 2 4 3.4 COc1ccc(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
10345812 18648 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccccc1NC(=O)N[C@@H]1C[C@H](c2ccccc2)c2ccccc2N(CC(=O)NC(C)(C)C)C1=O 10.1021/jm00048a015
CHEMBL127687 18648 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 498 5 3 3 5.0 Cc1ccccc1NC(=O)N[C@@H]1C[C@H](c2ccccc2)c2ccccc2N(CC(=O)NC(C)(C)C)C1=O 10.1021/jm00048a015
14843034 100139 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 5 1 4 5.0 COc1cccc(-n2c(CCc3c[nH]c4ccc(C)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL287739 100139 None 0 Mouse Binding pIC50 = 7.3 7.3 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 409 5 1 4 5.0 COc1cccc(-n2c(CCc3c[nH]c4ccc(C)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
14208259 204155 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 545 4 1 4 5.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2N(C(=O)c2ccc(Cl)cc2)C1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
CHEMBL70593 204155 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 545 4 1 4 5.9 O=C(NC1N=C(c2ccccc2F)c2ccccc2N(C(=O)c2ccc(Cl)cc2)C1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
44382563 120750 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(OS(=O)(=O)O)cc1 10.1016/S0960-894X(00)80687-3
CHEMBL355052 120750 None 0 Mouse Binding pIC50 = 6.3 6.3 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 742 15 5 7 5.3 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCCc1ccc(OS(=O)(=O)O)cc1 10.1016/S0960-894X(00)80687-3
44280388 116867 None 0 Mouse Binding pIC50 = 6.3 6.3 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL33819 116867 None 0 Mouse Binding pIC50 = 6.3 6.3 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
44280115 107225 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL31671 107225 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44382706 59018 None 2 Mouse Binding pIC50 = 6.3 6.3 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@@H](c2ccccc2)[C@@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL169274 59018 None 2 Mouse Binding pIC50 = 6.3 6.3 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)[C@@H](c2ccccc2)[C@@H]1c1ccccc1 10.1016/S0960-894X(00)80684-8
19766161 59181 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
CHEMBL170068 59181 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 403 4 3 3 3.4 O=C(O)CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)CCc2ccccc21 10.1016/S0960-894X(00)80683-6
44311988 103029 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 5 2 4 2.5 CN1C(=O)[C@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL307034 103029 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 5 2 4 2.5 CN1C(=O)[C@H](NC(=O)[C@H](N)Cc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44359881 119300 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 473 8 1 5 4.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)CCC(=O)OCc1ccccc1 10.1021/jm00163a069
CHEMBL343969 119300 None 0 Human Binding pIC50 = 4.3 4.3 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 473 8 1 5 4.1 CN1c2ccccc2C(c2ccccc2F)=NCC1CNC(=O)CCC(=O)OCc1ccccc1 10.1021/jm00163a069
136055866 56515 None 0 Human Binding pIC50 = 7.3 7.3 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL163610 56515 None 0 Human Binding pIC50 = 7.3 7.3 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 468 4 3 7 3.4 CN1C(=O)[C@H](NC(=O)Nc2ccc(-c3noc(O)n3)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
135494573 166745 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 395 3 2 6 3.5 Cc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
CHEMBL4283467 166745 None 0 Rat Binding pIC50 = 7.3 7.3 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 395 3 2 6 3.5 Cc1ccc(-n2c(N/N=C3\C(=O)Nc4ccccc43)nc3ccccc3c2=O)cc1 10.1039/C7MD00171A
44329442 207670 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](c3ccccc3)C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N2CC(=O)NC(C)(C)C)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL95369 207670 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1ccc([C@H]2C[C@@H](c3ccccc3)C[C@@H](NC(=O)Nc3cccc(C)c3)C(=O)N2CC(=O)NC(C)(C)C)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL3142689 211129 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
13605417 207566 None 4 Human Binding pIC50 = 5.3 5.3 - 1
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
CHEMBL9485 207566 None 4 Human Binding pIC50 = 5.3 5.3 - 1
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 458 14 2 3 5.2 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 10.1016/S0960-894X(00)80681-2
15104618 109039 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 496 13 3 2 6.8 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00116a002
CHEMBL321265 109039 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 496 13 3 2 6.8 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00116a002
44408632 158235 None 0 Human Binding pIC50 = 6.3 6.3 -2454 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL408832 158235 None 0 Human Binding pIC50 = 6.3 6.3 -2454 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
155555065 174332 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4550876 174332 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 71 17 23 2.9 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
11801355 116866 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 8 3 6 3.6 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
CHEMBL338186 116866 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 580 8 3 6 3.6 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1021/jm000959x
10744012 97377 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
CHEMBL269662 97377 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)cc1 10.1021/jm970373j
73349806 96440 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL262155 96440 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranesInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from guinea pig brain membranes
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44280122 99497 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL283276 99497 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 640 10 3 4 5.7 CN(C(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm950372w
44280622 119212 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
CHEMBL34332 119212 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 698 12 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2c1CCCC2 10.1021/jm950372w
6918156 97286 None 4 Human Binding pIC50 = 6.2 6.2 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL269016 97286 None 4 Human Binding pIC50 = 6.2 6.2 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 990 29 9 11 2.0 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
14991585 101024 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 21 7 10 4.3 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
CHEMBL294542 101024 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 919 21 7 10 4.3 CC(=O)Oc1ccc2cc(C(=O)NCCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc3ccccc3)C(N)=O)ccc2c1 10.1021/jm00089a010
44279862 99128 None 0 Human Binding pIC50 = 6.2 6.2 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281017 99128 None 0 Human Binding pIC50 = 6.2 6.2 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 702 13 3 7 5.9 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
15689730 106594 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 8 4.4 CC(C)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142694 106594 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 854 21 9 8 4.4 CC(C)c1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
10079035 163859 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 796 21 8 7 2.9 CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL420667 163859 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 796 21 8 7 2.9 CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44334379 108771 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 7 2 3 4.7 Cc1cccc(NC(=O)N[C@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL320901 108771 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 435 7 2 3 4.7 Cc1cccc(NC(=O)N[C@H](CC(C)C)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
155540739 172505 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4483457 172505 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1907 74 17 24 2.5 CCCC[C@H](NC(=O)[C@H](Cc1cc2ccccc2[nH]1)NC(=O)CNC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10009894 25626 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 694 13 6 6 4.9 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1016/s0960-894x(01)00630-8
CHEMBL13517 25626 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 694 13 6 6 4.9 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H]2C[C@@H](NC(=O)OCc3ccccc3)C(=O)N21 10.1016/s0960-894x(01)00630-8
14843039 118773 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 7 1 4 6.2 CCCOc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL34198 118773 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 7 1 4 6.2 CCCOc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
44303233 100653 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 C[C@](Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL292194 100653 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 C[C@](Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
10416987 12207 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 539 5 2 4 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL1184312 12207 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 539 5 2 4 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 10.1021/jm00078a018
CHEMBL343949 12207 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 539 5 2 4 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)N3CC[N+](C)(C)CC3)C2=O)c1 10.1021/jm00078a018
14208300 77821 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL2092866 77821 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@H](NC(=O)c2ccccc2Br)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44349392 16816 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.4 CC1(C)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
CHEMBL124712 16816 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.4 CC1(C)CCC(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
71461592 78484 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL2111828 78484 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 421 7 3 4 3.0 O=C(O)CC[C@H](NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
10530003 97001 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL266598 97001 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10530003 97001 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL266598 97001 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 5.3 CC(C)Oc1cccc(-n2c(CCNC(=O)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
10698905 206870 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cc(F)ccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL90697 206870 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 605 8 1 5 6.0 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4cc(F)ccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
10027443 116530 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3ncc[nH]3)C2=O)c1 10.1021/jm00078a018
CHEMBL336221 116530 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3ncc[nH]3)C2=O)c1 10.1021/jm00078a018
14991534 106790 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 825 22 8 8 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144531 106790 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 825 22 8 8 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44381960 120277 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL352573 120277 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 474 3 3 4 4.6 CN1C(=O)[C@@H](NC(=O)Nc2cc3c4ccccc4nc-3c[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
10576429 206632 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)c1 10.1021/jm970373j
CHEMBL8920 206632 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 473 7 3 8 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)c1 10.1021/jm970373j
CHEMBL2386887 210397 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCC(=O)N2CCC[C@H]2C(=O)NCC(=O)NCCCC(CCCNC(=O)CNC(=O)[C@@H]2CCCN2C(=O)CNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)CNC(=O)[C@@H]2CCCN2C(=O)CNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
73349793 206454 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1021/jm00092a007
CHEMBL88090 206454 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 638 12 5 7 4.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCc1nnn[nH]1)c1ccccc1 10.1021/jm00092a007
44356788 116704 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 496 6 3 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CCl)C1=O 10.1021/jm00078a018
CHEMBL337286 116704 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 496 6 3 4 4.3 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2)c2ccccc2N(C[C@@H](O)CCl)C1=O 10.1021/jm00078a018
10408567 119277 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
CHEMBL343767 119277 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
4627 821 None 50 Rat Binding pIC50 = 8.2 8.2 1 5
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
864 821 None 50 Rat Binding pIC50 = 8.2 8.2 1 5
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
9833444 821 None 50 Rat Binding pIC50 = 8.2 8.2 1 5
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
CHEMBL1121 821 None 50 Rat Binding pIC50 = 8.2 8.2 1 5
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
DB09142 821 None 50 Rat Binding pIC50 = 8.2 8.2 1 5
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B)
ChEMBL None None None None 10.1016/S0960-894X(97)00107-8
44367000 119694 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
CHEMBL347329 119694 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Ability to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brainAbility to displace [125I]CCK-8 from gastrin/Cholecystokinin type B receptor from rat brain
ChEMBL 494 6 2 4 5.1 Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1016/0960-894X(95)00556-9
44303243 202923 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 545 9 5 5 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL62832 202923 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 545 9 5 5 4.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)[C@H](O)c1ccccc1 10.1016/S0960-894X(97)00356-9
44359376 119357 None 1 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1O 10.1021/jm970065l
CHEMBL344380 119357 None 1 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 493 6 4 4 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CCCCC1O 10.1021/jm970065l
44283055 116610 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80156-0
CHEMBL336769 116610 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 4.2-8.9
ChEMBL 515 9 4 4 4.4 O=C(NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80156-0
73346724 206086 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 13 5 9 5.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NC1N=NN=N1)c1ccccc1 10.1021/jm00092a007
CHEMBL85607 206086 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 681 13 5 9 5.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCC(=O)NC1N=NN=N1)c1ccccc1 10.1021/jm00092a007
9984452 165301 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00105a062
CHEMBL423329 165301 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00105a062
44368624 121131 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 9 4 3 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL357564 121131 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 9 4 3 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
9984452 29712 None 0 Mouse Binding pIC50 = 8.2 8.2 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm970065l
CHEMBL138657 29712 None 0 Mouse Binding pIC50 = 8.2 8.2 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm970065l
15673180 85995 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7
ChEMBL 681 13 6 8 3.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)Nc1nn[nH]n1)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304157 85995 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 5.3 to 7.7
ChEMBL 681 13 6 8 3.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)Nc1nn[nH]n1)c1ccccc1 10.1016/S0960-894X(00)80652-6
5311201 207393 None 35 Human Binding pIC50 = 8.2 8.2 -27 6
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00001a027
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.2 8.2 -27 6
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00001a027
10484212 99877 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
CHEMBL285921 99877 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesInhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranes
ChEMBL 635 6 3 7 4.3 Cc1cccc2c1N(CC(=O)N1CC3CCC(CC3)C1)C(=O)C(NC(=O)Nc1cccc(-c3nn[nH]n3)c1)N=C2c1ccccc1F 10.1016/S0960-894X(96)00609-9
9984452 165301 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL423329 165301 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
10475990 115996 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
CHEMBL33554 115996 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00078a018
44368633 46543 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153787 46543 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCCC1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00057a005
10577834 116742 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 518 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CC2CCC(CC2)C1 10.1021/jm970065l
CHEMBL337529 116742 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 518 6 3 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NN1CC2CCC(CC2)C1 10.1021/jm970065l
15637206 78899 None 0 Human Binding pIC50 = 8.2 8.2 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 428 4 3 4 3.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(C(=O)O)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
CHEMBL2112932 78899 None 0 Human Binding pIC50 = 8.2 8.2 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 428 4 3 4 3.3 CN1C(=O)[C@H](NC(=O)Nc2ccc(C(=O)O)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00032a003
44269000 32914 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(00)00198-0
CHEMBL14153 32914 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneBinding affinity towards Cholecystokinin type B receptor in mouse cortex membrane
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(00)00198-0
10099144 114539 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccc(Cl)cc21 10.1021/jm00048a015
CHEMBL333671 114539 None 0 Human Binding pIC50 = 8.2 8.2 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 552 5 3 3 6.0 CC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccc(Cl)cc21 10.1021/jm00048a015
44269000 32914 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(01)00630-8
CHEMBL14153 32914 None 0 Rat Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptorInhibition of [3H]propionyl-CCK-8 specific binding to rat cerebral cortex membranes Cholecystokinin type B receptor
ChEMBL 671 14 6 5 6.3 Cc1ccccc1NC(=O)NCCCC[C@@H](CC(=O)O)NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(01)00630-8
9853654 22787 None 41 Rat Binding pIC50 = 8.2 8.2 - 2
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
CHEMBL1328 22787 None 41 Rat Binding pIC50 = 8.2 8.2 - 2
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
10392523 207942 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL96970 207942 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
10075052 189672 None 0 Human Binding pIC50 = 8.2 8.2 -10 2
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL515268 189672 None 0 Human Binding pIC50 = 8.2 8.2 -10 2
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL515288 189672 None 0 Human Binding pIC50 = 8.2 8.2 -10 2
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10409900 103856 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL30919 103856 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 420 3 2 3 4.5 Cc1cccc(NC(=O)N[C@@H]2C[C@@H](N3CCCCCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
44368382 45337 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL152682 45337 None 0 Mouse Binding pIC50 = 8.2 8.2 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 511 9 4 4 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1CCCCC1Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
71452818 79712 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL2115543 79712 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
44280372 99385 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282645 99385 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 787 17 4 8 5.8 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL287751 210864 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
CHEMBL37900 212262 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
10816869 51851 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
CHEMBL158547 51851 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Compound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortexCompound was tested for the inhibition of specific binding of [125I]bolton Hunter CCK-8 to Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 569 8 3 5 5.2 COC(=O)[C@]1(NC(=O)[C@@](C)(Cc2c[nH]c3ccccc23)NC(=O)OC2C3CC4CC(C3)CC2C4)C[C@H]1c1ccccc1 10.1016/S0960-894X(01)81250-6
44211354 12862 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 536 6 1 4 4.2 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1188705 12862 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 536 6 1 4 4.2 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL537171 12862 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortexDisplacement of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor of guinea pig brain cortex
ChEMBL 536 6 1 4 4.2 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
44381489 97191 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL268337 97191 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
44349069 118057 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL340413 118057 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44280115 107225 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL31671 107225 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 658 11 3 6 5.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(C(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
9853654 22787 None 41 Human Binding pIC50 = 5.2 5.2 31 2
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
CHEMBL1328 22787 None 41 Human Binding pIC50 = 5.2 5.2 31 2
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00079a003
44375216 56538 None 0 Mouse Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 3.8 O=C(O)CN(CCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL163816 56538 None 0 Mouse Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 596 13 5 7 3.8 O=C(O)CN(CCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44375424 120141 None 0 Mouse Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.2 O=C(O)CN(CCCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
CHEMBL351310 120141 None 0 Mouse Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assayIn vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay
ChEMBL 610 14 5 7 4.2 O=C(O)CN(CCCc1ccccc1)S(=O)(=O)c1ccc(N/N=C(/S)NCCc2c[nH]c3ccccc23)c([N+](=O)[O-])c1 10.1016/s0960-894x(01)00044-0
44377589 120156 None 0 Human Binding pIC50 = 5.2 5.2 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
CHEMBL351506 120156 None 0 Human Binding pIC50 = 5.2 5.2 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 635 15 6 6 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
44349101 16842 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 468 7 3 3 5.0 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL124805 16842 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 468 7 3 3 5.0 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
13953698 101907 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 464 5 1 5 5.1 CN(C)Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
CHEMBL300926 101907 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 464 5 1 5 5.1 CN(C)Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=N[C@@H]2Cc1c[nH]c2ccccc12 10.1021/jm00396a028
14208273 67736 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 457 7 1 3 5.1 CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 10.1021/jm00120a002
CHEMBL1907840 67736 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 457 7 1 3 5.1 CCCCCc1ccc(C(=O)N[C@H]2N=C(c3ccccc3F)c3ccccc3N(C)C2=O)cc1 10.1021/jm00120a002
155517761 170221 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4445529 170221 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1900 71 16 23 4.4 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1021/acs.jmedchem.8b01558
10507071 113608 None 0 Human Binding pIC50 = 5.2 5.2 - 1
Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptorInhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptor
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm0501127
CHEMBL332261 113608 None 0 Human Binding pIC50 = 5.2 5.2 - 1
Inhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptorInhibition of CCK binding to Cos-7 cells expressing human cholecystokinin 2 receptor
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm0501127
10002123 78809 None 1 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112748 78809 None 1 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44280316 96762 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL264606 96762 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 680 11 4 5 5.8 O=C(C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O)Nc1cccc2ccccc12 10.1021/jm950372w
44210426 59116 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169807 59116 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.Ability to inhibit the binding of [125I]-gastrin to gastric glands in guinea pig.
ChEMBL 449 4 2 4 2.2 Cc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)N3CCN(C)CC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
10011110 161327 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 948 24 8 7 5.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL412544 161327 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 948 24 8 7 5.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL106722 208470 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14991536 106825 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144567 106825 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 841 22 9 9 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL170026 208838 None 0 Mouse Binding pIC50 = 4.2 4.2 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
10744084 207150 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 503 8 3 9 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)c(OC)c2)c1 10.1021/jm970373j
CHEMBL9230 207150 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 503 8 3 9 3.7 CCOC(=O)c1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(OC)c(OC)c2)c1 10.1021/jm970373j
44279853 104791 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
CHEMBL31093 104791 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 593 10 3 4 5.6 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](CC1CCCCC1)C(=O)O 10.1021/jm950372w
10507071 113608 None 0 Rat Binding pIC50 = 5.2 5.2 - 1
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm991078x
CHEMBL332261 113608 None 0 Rat Binding pIC50 = 5.2 5.2 - 1
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm991078x
44396744 124044 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 516 7 2 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
CHEMBL363106 124044 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 516 7 2 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)CC12 10.1021/jm0498755
10626665 10259 None 0 Rat Binding pIC50 = 5.2 5.2 - 1
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010898i
CHEMBL116127 10259 None 0 Rat Binding pIC50 = 5.2 5.2 - 1
Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortexInhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010898i
10626665 10259 None 0 Rat Binding pIC50 = 5.2 5.2 - 1
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010813d
CHEMBL116127 10259 None 0 Rat Binding pIC50 = 5.2 5.2 - 1
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm010813d
CHEMBL385727 212359 None 0 Bovine Binding pIC50 = 5.2 5.2 - 0
Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.Concentration inhibiting [3H]propionyl-CCK-8 binding to cholecystokinin type B receptor of bovine striatum.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CSC(C)(C)[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00100a033
14888722 77246 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079601 77246 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1055 30 11 14 -0.2 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(Cc2nnn[nH]2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079548 209189 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44280245 100033 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
CHEMBL286941 100033 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 12 3 5 6.2 CN(C(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1cccc2ccccc12 10.1021/jm950372w
CHEMBL2370120 209784 None 0 Bovine Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](Cc1ccc(CCC(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
14208312 77820 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2092865 77820 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 437 3 1 3 4.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C(F)(F)F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44381513 168692 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL436690 168692 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
44349324 16671 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL124261 16671 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(C(F)(F)F)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
10693825 207054 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 428 5 3 6 3.9 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
CHEMBL9171 207054 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 428 5 3 6 3.9 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(N(C)C)c2)c1 10.1021/jm970373j
44354125 23149 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL133101 23149 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 628 13 5 5 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
14802539 76550 None 1 Mouse Binding pIC50 = 7.2 7.2 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL2062144 76550 None 1 Mouse Binding pIC50 = 7.2 7.2 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80685-X
44280414 101857 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
CHEMBL30061 101857 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 708 13 4 5 5.9 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCc1cccc2ccccc12 10.1021/jm950372w
44280388 116867 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL33819 116867 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 759 15 4 8 5.0 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
11613212 72099 None 0 Dog Binding pIC50 = 7.2 7.2 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL197780 72099 None 0 Dog Binding pIC50 = 7.2 7.2 - 3
Concentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptorConcentration required to inhibit the binding of [125I]-BH-CCK-8S radioligand to canine gastric mucosa CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL1171596 208577 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
14208236 204679 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 4 3.9 Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 10.1021/jm00120a002
CHEMBL73885 204679 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 426 3 2 4 3.9 Cn1c(C(=O)NC2N=C(c3ccccc3F)c3ccccc3NC2=O)cc2ccccc21 10.1021/jm00120a002
23129945 9608 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 604 16 2 4 7.8 CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccc(OCc3ccccc3)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL112612 9608 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 604 16 2 4 7.8 CCCCCN(CCCCC)C(=O)C(Cc1c[nH]c2ccc(OCc3ccccc3)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
44306868 102081 None 0 Human Binding pIC50 = 4.2 4.2 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 836 18 9 7 3.7 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
CHEMBL302150 102081 None 0 Human Binding pIC50 = 4.2 4.2 - 1
Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes
ChEMBL 836 18 9 7 3.7 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC(Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(C)cc1)C(N)=O 10.1021/jm00001a027
10000984 116641 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cnccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL336972 116641 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3cnccc3N(C)C2=O)c1 10.1021/jm00078a018
44281020 116642 None 0 Mouse Binding pIC50 = 7.2 7.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33698 116642 None 0 Mouse Binding pIC50 = 7.2 7.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 6.2 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44327458 207855 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL96469 207855 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 571 11 3 4 5.6 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
10432393 100344 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
CHEMBL289533 100344 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 422 3 3 3 4.4 O=C(Nc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00121a004
10323690 100496 None 0 Mouse Binding pIC50 = 6.2 6.2 - 2
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00086a017
CHEMBL2114401 100496 None 0 Mouse Binding pIC50 = 6.2 6.2 - 2
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00086a017
CHEMBL291033 100496 None 0 Mouse Binding pIC50 = 6.2 6.2 - 2
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00086a017
10418081 110370 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 840 23 9 8 2.4 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL324219 110370 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 840 23 9 8 2.4 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL319438 211215 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
14208274 169290 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL441445 169290 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 443 3 1 3 4.7 CN1C(=O)C(NC(=O)c2ccc(C(C)(C)C)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL169054 208833 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
13822922 189078 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 436 3 2 5 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1cc2ccccc2[nH]1 10.1021/jm00396a028
CHEMBL50986 189078 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 436 3 2 5 4.2 O=C(NC1N=C(c2ccccc2F)c2ccccc2-n2cnnc21)c1cc2ccccc2[nH]1 10.1021/jm00396a028
73349806 96440 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL262155 96440 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1019 29 9 11 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCOc1ccccc1)CC(=O)O 10.1021/jm00072a024
44329287 207633 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccc(F)cc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL95209 207633 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 544 6 3 3 5.7 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccc(F)cc3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL169054 208833 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptorTested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptor
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
10553685 119149 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
CHEMBL342907 119149 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 508 8 3 5 4.2 COC[C@@H]1CCCN1NC(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm970065l
19766160 58507 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
CHEMBL168386 58507 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 456 4 2 3 3.9 O=C(Nc1cccc2ccccc12)NC1CCc2ccccc2N(CC(=O)N2CCCC2)C1=O 10.1016/S0960-894X(00)80683-6
14208232 204137 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 452 5 3 4 3.2 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL70456 204137 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 452 5 3 4 3.2 O=C(O)CN1C(=O)C(NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2111881 209218 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
CHEMBL2111882 209219 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
10485763 109674 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 860 21 8 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Oc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL322635 109674 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 860 21 8 8 4.2 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Oc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
44379627 58130 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 4.9 CC(C)Oc1cccc(-n2c(CNC(=O)NCc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL167758 58130 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 520 7 2 5 4.9 CC(C)Oc1cccc(-n2c(CNC(=O)NCc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
44280246 102162 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
CHEMBL30262 102162 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2ccccc2c1 10.1021/jm950372w
44280510 102953 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
CHEMBL30639 102953 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 621 10 3 4 5.5 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)NC(Cc1ccc(Cl)cc1)C(=O)O 10.1021/jm950372w
10341040 116607 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL336749 116607 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 402 3 2 3 3.8 CN1C(=O)C(NC(=O)Nc2ccc(F)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10363545 205739 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL82685 205739 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
10363545 205739 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL82685 205739 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3ccccn3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
44329286 107203 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3cccc(C)c3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL316619 107203 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3cccc(C)c3)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
155568312 176076 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4591101 176076 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1836 72 17 23 3.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44280713 100030 None 0 Mouse Binding pIC50 = 5.2 5.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286907 100030 None 0 Mouse Binding pIC50 = 5.2 5.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 740 15 6 9 3.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
155543163 173284 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4525615 173284 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1886 72 16 25 2.5 CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
14843040 100140 None 1 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 527 6 1 4 6.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(OC2CCCC2)c1 10.1021/jm00108a040
CHEMBL287740 100140 None 1 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 527 6 1 4 6.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccc(Br)cc23)n1-c1cccc(OC2CCCC2)c1 10.1021/jm00108a040
14843035 139825 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 425 6 1 5 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccc(OC)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37990 139825 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 425 6 1 5 4.7 COc1cccc(-n2c(CCc3c[nH]c4ccc(OC)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10479056 26184 None 13 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)c(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135702 26184 None 13 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 452 3 2 3 5.0 CN1C(=O)C(NC(=O)Nc2ccc(Cl)c(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44279939 99315 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
CHEMBL282149 99315 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 637 10 3 4 6.0 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@H](Cc1cccc2ccccc12)C(=O)O 10.1021/jm950372w
14843023 138048 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00092a003
CHEMBL37653 138048 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00092a003
14843023 138048 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00108a040
CHEMBL37653 138048 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 365 4 1 3 4.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1 10.1021/jm00108a040
136046102 100675 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 864 20 9 10 3.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2cccc(O)c2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292298 100675 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 864 20 9 10 3.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cnc2cccc(O)c2c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14208243 204415 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL72073 204415 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14208243 204415 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
CHEMBL72073 204415 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Tested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pigTested for its activity to inhibit the binding of [125I]gastrin to gastric glands (gastrin) in guinea pig
ChEMBL 403 3 1 3 3.9 CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80682-4
19754257 120375 None 1 Human Binding pIC50 = 4.2 4.2 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 340 3 3 2 4.3 O=C(Cc1c[nH]c2ccccc12)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL353304 120375 None 1 Human Binding pIC50 = 4.2 4.2 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 340 3 3 2 4.3 O=C(Cc1c[nH]c2ccccc12)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
44280406 119524 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
CHEMBL34569 119524 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 12 3 5 5.1 CN(C(=O)[C@@H](CCC(=O)O)NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)c1ccccc1 10.1021/jm950372w
44303650 100777 None 0 Mouse Binding pIC50 = 5.2 5.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 548 6 2 3 6.4 O=C(NC1(C(=O)NCCc2ccccc2)CC2(Cc3cccc4cccc(c34)C2)C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
CHEMBL292956 100777 None 0 Mouse Binding pIC50 = 5.2 5.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 548 6 2 3 6.4 O=C(NC1(C(=O)NCCc2ccccc2)CC2(Cc3cccc4cccc(c34)C2)C1)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(97)00356-9
14888706 77249 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1017 29 11 12 0.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079604 77249 None 0 Bovine Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1017 29 11 12 0.4 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(C(=O)O)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44303238 163235 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 536 10 4 6 3.8 COc1ccc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)N[C@H](CO)[C@H](O)c2ccccc2)cc1 10.1016/S0960-894X(97)00356-9
CHEMBL418464 163235 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 536 10 4 6 3.8 COc1ccc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)N[C@H](CO)[C@H](O)c2ccccc2)cc1 10.1016/S0960-894X(97)00356-9
14208295 67747 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907850 67747 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
44279808 99139 None 0 Mouse Binding pIC50 = 5.2 5.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL281082 99139 None 0 Mouse Binding pIC50 = 5.2 5.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 712 13 6 9 2.9 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
44209154 59092 None 1 Human Binding pIC50 = 4.2 4.2 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
CHEMBL169675 59092 None 1 Human Binding pIC50 = 4.2 4.2 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 315 4 2 2 4.2 O=C(CCc1ccccc1)Nc1cc2c3ccccc3nc-2c[nH]1 10.1016/S0960-894X(00)80682-4
14208242 156421 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL40668 156421 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
14208242 156421 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL40668 156421 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 493 6 1 5 4.0 CCOC(=O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14843028 118757 None 6 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 399 4 1 3 5.3 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Cl)c1 10.1021/jm00108a040
CHEMBL34185 118757 None 6 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 399 4 1 3 5.3 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(Cl)c1 10.1021/jm00108a040
44379965 57836 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 496 6 2 5 5.5 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL167169 57836 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 496 6 2 5 5.5 CC(C)Oc1cccc(-n2c(CNC(=O)Nc3ccc(C(F)(F)F)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
44280993 118335 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
CHEMBL34101 118335 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 678 12 4 5 5.5 CC1(C)CCC(NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1021/jm950372w
46235271 73646 None 2 Human Binding pIC50 = 6.2 6.2 -2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pIC50 = 6.2 6.2 -2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
10769902 206543 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
CHEMBL88629 206543 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm960249k
10769902 206543 None 0 Human Binding pIC50 = 4.2 4.2 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL88629 206543 None 0 Human Binding pIC50 = 4.2 4.2 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 8 1 5 6.3 COc1ccc(N(C(=O)CN2C(=O)C(C)(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C(C)C)cc1 10.1021/jm970265x
CHEMBL434674 213658 None 0 Human Binding pIC50 = 4.2 4.2 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None CN[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
44303251 102232 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 618 12 5 5 4.6 O=C(O)CCC(=O)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL303020 102232 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 618 12 5 5 4.6 O=C(O)CCC(=O)N[C@@H](CNC(=O)C(Cc1c[nH]c2ccc(F)cc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1016/S0960-894X(97)00356-9
443375 207604 None 45 Rat Binding pIC50 = 6.2 6.2 -389 5
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm991078x
CHEMBL9506 207604 None 45 Rat Binding pIC50 = 6.2 6.2 -389 5
Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membraneBinding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm991078x
443375 207604 None 45 Rat Binding pIC50 = 6.2 6.2 -389 5
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000959x
CHEMBL9506 207604 None 45 Rat Binding pIC50 = 6.2 6.2 -389 5
In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.In vitro inhibition of [3H]propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm000959x
44280621 103923 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
CHEMBL30926 103923 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 658 13 4 5 4.4 O=C(O)C[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)NCCc1ccccc1 10.1021/jm950372w
13822923 194814 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 450 3 2 5 4.5 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=NC2NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00396a028
CHEMBL53907 194814 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]gastrin from guinea pig gastric glandsDisplacement of [125I]gastrin from guinea pig gastric glands
ChEMBL 450 3 2 5 4.5 Cc1nnc2n1-c1ccccc1C(c1ccccc1F)=NC2NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00396a028
44281205 114816 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL33412 114816 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 857 17 4 10 5.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL386811 212391 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Tested for inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic aciniTested for inhibition of [125I]BH-CCK- binding to peripheral cholecystokinin type B receptor from rat pancreatic acini
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)OCCc1ccccc1 10.1021/jm00072a024
104929 2217 None 9 Human Binding pIC50 = 8.2 8.2 51 3
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
3477 2217 None 9 Human Binding pIC50 = 8.2 8.2 51 3
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
879 2217 None 9 Human Binding pIC50 = 8.2 8.2 51 3
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
CHEMBL289498 2217 None 9 Human Binding pIC50 = 8.2 8.2 51 3
Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexDisplacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00121a004
11756709 22874 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 528 9 3 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)CCC(=O)O)C2=O)c1 10.1021/jm00078a018
CHEMBL132875 22874 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 528 9 3 6 3.7 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)CCC(=O)O)C2=O)c1 10.1021/jm00078a018
5311201 207393 None 35 Mouse Binding pIC50 = 8.1 8.1 -26 6
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 8.1 8.1 -26 6
Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00108a040
10648445 58911 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 6 4 7 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
CHEMBL168903 58911 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 481 6 4 7 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(CNc3nn[nH]n3)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9506736
10047669 78515 None 1 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2111924 78515 None 1 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
46235271 73646 None 2 Human Binding pIC50 = 8.1 8.1 -2 2
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pIC50 = 8.1 8.1 -2 2
Displacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from human CCK2R H7.39L mutant expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
10003805 107462 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Compound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexCompound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL318360 107462 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Compound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexCompound was tested for its binding affinity by measuring the displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)[C@H](NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
10369803 16580 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 7 3 3 5.7 CCC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
CHEMBL123951 16580 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 532 7 3 3 5.7 CCC(C)(C)NC(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(Cl)c2)C[C@H](c2ccccc2)c2ccccc21 10.1021/jm00048a015
15667017 208174 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 1.7 CCCC[C@H](NC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98332 208174 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 1.7 CCCC[C@H](NC(=O)/C=C/c1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
10392698 117304 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 5 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(Cl)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1021/jm00048a015
CHEMBL339678 117304 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 546 5 3 3 5.9 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(Cl)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1021/jm00048a015
10392523 207942 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL96970 207942 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 540 6 3 3 5.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44301036 198702 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 8 4 6 5.4 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3C)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
CHEMBL58154 198702 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 695 8 4 6 5.4 Cc1ccc2c(c1)N(CC(=O)NC(C)(C)C)C(=O)[C@H](NC(=O)Nc1cccc(C(=O)NS(=O)(=O)c3ccccc3C)c1)C[C@@H]2c1ccccc1 10.1016/0960-894X(95)00327-P
15666987 208195 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortexIn vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL98446 208195 None 0 Human Binding pIC50 = 8.1 8.1 - 0
In vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortexIn vitro binding affinity towards Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 976 29 10 11 1.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00094a001
9934162 27729 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3c[nH]cn3)C2=O)c1 10.1021/jm00078a018
CHEMBL137043 27729 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 464 5 3 4 4.3 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3c[nH]cn3)C2=O)c1 10.1021/jm00078a018
101918113 115412 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL 650 14 6 7 0.7 CS[C@H]1C[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 10.1021/jm00001a019
CHEMBL3350334 115412 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL 650 14 6 7 0.7 CS[C@H]1C[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)N(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)C1 10.1021/jm00001a019
CHEMBL37984 212265 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
73349790 106174 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 725 14 5 6 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00092a007
CHEMBL313756 106174 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 725 14 5 6 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00092a007
14994683 205975 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(CC(C)c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL84659 205975 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(CC(C)c3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
44381202 161829 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL414523 161829 None 0 Human Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
44381463 96824 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL265147 96824 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
In vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic aciniIn vitro binding affinity against Cholecystokinin type B receptor of rat pancreatic acini
ChEMBL 1124 30 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(c1ccccc1)c1ccccc1 10.1016/S0960-894X(00)80679-4
44396785 67176 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 530 7 2 5 4.6 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
CHEMBL187732 67176 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 530 7 2 5 4.6 C[C@H]1C(=O)N(Cc2ccccc2)C(=O)N2CCC[C@@H](N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OC(C)(C)C)C12 10.1021/jm0498755
19910130 119789 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 439 14 3 3 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
CHEMBL348168 119789 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 439 14 3 3 4.9 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)Nc1ccc(Cl)cc1 10.1021/jm00164a020
44349203 117052 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
CHEMBL339134 117052 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NN1CCC2(CCCCC2)C1 10.1021/jm00079a003
44211352 13983 None 0 Human Binding pIC50 = 6.2 6.2 - 0
The compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptorThe compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor
ChEMBL 522 6 1 4 3.8 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL1196916 13983 None 0 Human Binding pIC50 = 6.2 6.2 - 0
The compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptorThe compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor
ChEMBL 522 6 1 4 3.8 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
CHEMBL558614 13983 None 0 Human Binding pIC50 = 6.2 6.2 - 0
The compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptorThe compound was tested for its activity to inhibit the specific binding of [3H](N-methyl-N-leucine)-CCK-8 to Cholecystokinin type B receptor
ChEMBL 522 6 1 4 3.8 CN1CCN(C(=O)CCC(NC(=O)c2cc(Cl)cc(Cl)c2)C(=O)N2CCC3(CCCC3)CC2)CC1 10.1016/S0960-894X(00)80681-2
15689728 106599 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1c(Cl)cccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142703 106599 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.6 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1c(Cl)cccc1Cl)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL431899 213627 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44381577 96634 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O 10.1016/S0960-894X(00)80680-0
CHEMBL263525 96634 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 840 23 10 10 2.9 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@H](CNN[C@@H](Cc1ccccc1)C(N)=O)CC(=O)O 10.1016/S0960-894X(00)80680-0
44311923 204499 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 4 2 3 4.0 O=C(Cc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
CHEMBL72570 204499 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 4 2 3 4.0 O=C(Cc1ccc(Cl)cc1)NC1N=C(c2ccccc2F)c2ccccc2NC1=O 10.1021/jm00120a002
14720386 48322 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 463 12 2 4 4.4 CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
CHEMBL155406 48322 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 463 12 2 4 4.4 CCCN(CCC)C(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00164a020
14991539 106792 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 859 22 8 8 3.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144533 106792 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 859 22 8 8 3.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349410 16775 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.5 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCC1 10.1021/jm00079a003
CHEMBL124459 16775 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 394 7 3 3 3.5 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCCCCCC1 10.1021/jm00079a003
CHEMBL172177 208849 None 0 Mouse Binding pIC50 = 4.2 4.2 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@@H](Cc2ccccc2)NC(=O)[C@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
44280110 102888 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
CHEMBL30592 102888 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 587 10 3 4 4.9 O=C(CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm950372w
10350069 9971 None 0 Human Binding pIC50 = 5.2 5.2 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
CHEMBL114774 9971 None 0 Human Binding pIC50 = 5.2 5.2 - 0
In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cellsIn vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells
ChEMBL 742 17 7 6 5.8 Cc1ccccc1NC(=O)NCCCC[C@@H](CNC(=O)CCC(=O)O)NC(=O)[C@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00017a022
44283246 99960 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL286442 99960 None 0 Mouse Binding pIC50 = 6.2 6.2 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 527 8 2 4 6.8 O=C(NC(Cc1c[nH]c2ccccc12)C1CN=C(CCc2ccccc2)S1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44329323 107341 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL317615 107341 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 574 7 3 3 6.9 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3ccccc3C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44381815 59005 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 838 21 7 9 4.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL169126 59005 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 838 21 7 9 4.0 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
9962694 168232 None 4 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 21 8 9 3.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL433640 168232 None 4 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 853 21 8 9 3.3 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280381 102942 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
CHEMBL30634 102942 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 511 9 3 4 3.6 O=C(O)CCNC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1 10.1021/jm950372w
11734332 78590 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 551 6 3 5 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@H]12 10.1021/jm010813d
CHEMBL2112233 78590 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranesInhibition of [3H]pCCK-8 specific binding cholecystokinin type B receptor in rat cerebral cortex membranes
ChEMBL 551 6 3 5 4.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)N(C3CCCCC3)C(=O)C[C@H]12 10.1021/jm010813d
10047370 78815 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 413 4 3 4 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CN)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL2112754 78815 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 413 4 3 4 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CN)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44381513 168692 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL436690 168692 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1139 31 10 12 4.9 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NC(Cc1ccccc1)Cc1ccccc1 10.1016/S0960-894X(00)80679-4
14843031 141291 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 393 5 1 3 5.2 CCc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL38330 141291 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 393 5 1 3 5.2 CCc1cccc(-n2c(CCc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10389643 119019 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 5 3 4 3.8 O=C(O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL342614 119019 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 462 5 3 4 3.8 O=C(O)CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
3476 1399 None 9 Human Binding pIC50 = 6.1 6.1 -117 3
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
59751 1399 None 9 Human Binding pIC50 = 6.1 6.1 -117 3
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
878 1399 None 9 Human Binding pIC50 = 6.1 6.1 -117 3
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
CHEMBL39263 1399 None 9 Human Binding pIC50 = 6.1 6.1 -117 3
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm00120a002
19754254 120348 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 321 2 2 2 4.6 O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccc(Cl)cc1 10.1016/S0960-894X(00)80682-4
CHEMBL353088 120348 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Tested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brainTested for its activity to inhibit the binding of [125I]CCK-33 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 321 2 2 2 4.6 O=C(Nc1cc2c3ccccc3nc-2c[nH]1)c1ccc(Cl)cc1 10.1016/S0960-894X(00)80682-4
44396745 125036 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
CHEMBL364334 125036 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cellsInhibition of 125I]-BH-(Thr,Nle)-CCK-9 binding to human CCK2 receptor expressed in COS-7 cells
ChEMBL 623 8 2 6 5.5 CN(C)c1ccc(N2C(=O)CC3[C@H](N[C@@H](Cc4c[nH]c5ccccc45)C(=O)OC4C5CC6CC(C5)CC4C6)CCCN3C2=O)cc1 10.1021/jm0498755
10817407 107129 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 7 1 6 5.6 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2 10.1021/jm970265x
CHEMBL316106 107129 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 601 7 1 6 5.6 CC(C)N(C(=O)CN1C(=O)C(Cc2n[nH]c3ccccc23)C(=O)N(c2ccccc2)c2ccccc21)c1ccc2c(c1)OCO2 10.1021/jm970265x
44280113 168228 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
CHEMBL433623 168228 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 684 12 4 5 5.5 O=C(O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1ccc2c(c1)CCC2 10.1021/jm950372w
10575687 207238 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
CHEMBL9287 207238 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(Cl)c2Cl)c1 10.1021/jm970373j
10074366 120596 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 120596 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 120596 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44381479 59522 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 824 21 8 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
CHEMBL171593 59522 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptorDisplacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor
ChEMBL 824 21 8 9 3.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80680-0
10452527 140717 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 383 4 1 3 4.8 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(F)c1 10.1021/jm00108a040
CHEMBL38176 140717 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 383 4 1 3 4.8 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(F)c1 10.1021/jm00108a040
90663974 106795 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144536 106795 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14991584 161740 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 877 20 8 9 4.1 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL413768 161740 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 877 20 8 9 4.1 CN(C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCNC(=O)c1ccc2cc(O)ccc2c1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14208280 67686 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 335 3 1 3 2.6 CC(C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00120a002
CHEMBL1907665 67686 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 335 3 1 3 2.6 CC(C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O 10.1021/jm00120a002
44458096 85047 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 388 5 2 3 2.7 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80224-3
CHEMBL22417 85047 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranesDisplacement of [125I]CCK-OP radioligand from Cholecystokinin type B receptor of guinea pig cortical membranes
ChEMBL 388 5 2 3 2.7 O=C(N[C@@H]1C(=O)N(Cc2ccccc2)C[C@@H]1C(=O)O)c1ccc2ccccc2c1 10.1016/S0960-894X(00)80224-3
CHEMBL172135 208848 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
10260206 167472 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 918 21 8 8 4.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL429932 167472 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 918 21 8 8 4.9 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
15104595 10090 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL115456 10090 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 498 13 2 3 6.3 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
15167799 119185 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 379 4 2 4 3.9 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1ccsc1 10.1021/jm00163a069
CHEMBL343158 119185 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesInhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissues
ChEMBL 379 4 2 4 3.9 O=C(NCC1CNc2ccccc2C(c2ccccc2F)=N1)c1ccsc1 10.1021/jm00163a069
10819755 165440 None 0 Human Binding pIC50 = 5.1 5.1 - 2
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL423907 165440 None 0 Human Binding pIC50 = 5.1 5.1 - 2
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
155551968 174015 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1793 69 16 20 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4542927 174015 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1793 69 16 20 4.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
73346731 81544 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL216079 81544 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat TcellsInhibition of [125I]BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells
ChEMBL 1017 29 9 10 5.4 CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CCCCc1ccccc1)CC(=O)O 10.1021/jm00072a024
CHEMBL432671 168093 None 0 Mouse Binding pIC50 = 7.1 7.1 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 784 15 7 12 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCNC(=O)CC(=O)NCCSCc3csc(C=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44280714 100031 None 0 Human Binding pIC50 = 7.1 7.1 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL286908 100031 None 0 Human Binding pIC50 = 7.1 7.1 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.2 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL2370879 209939 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pigCompound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00105a068
CHEMBL3142924 211136 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None COc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1 10.1021/jm960509y
14208293 67748 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907851 67748 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 3 1 3 4.2 CN1C(=O)[C@@H](NC(=O)c2cccc(Br)c2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14444018 106674 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
CHEMBL3143387 106674 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbitIn vitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit
ChEMBL 649 16 6 6 3.8 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)CC(=O)NCCc1ccccc1 10.1021/jm00123a003
90663982 106810 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 21 10 10 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144551 106810 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 855 21 10 10 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
14208251 77825 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2092870 77825 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 403 3 1 3 3.9 CN1C(=O)[C@H](NC(=O)c2ccccc2Cl)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44377488 57505 None 0 Human Binding pIC50 = 4.1 4.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 693 21 6 8 3.5 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1 10.1021/jm00388a002
CHEMBL166089 57505 None 0 Human Binding pIC50 = 4.1 4.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 693 21 6 8 3.5 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1 10.1021/jm00388a002
10279334 125055 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 8 2 3 5.7 CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL36443 125055 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 513 8 2 3 5.7 CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
155535107 172012 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4471525 172012 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1904 73 19 22 4.7 CCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
14888719 77234 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
CHEMBL2079547 77234 None 0 Bovine Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL 1041 29 11 14 -0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(-c2nn[nH]n2)cc1)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
44280373 99386 None 0 Mouse Binding pIC50 = 6.1 6.1 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL282646 99386 None 0 Mouse Binding pIC50 = 6.1 6.1 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.4 Cc1cccc(NC(=O)NC2N=C(c3cccc(OCC(=O)NCCC(=O)NCCCOc4cccc(CN5CCCCC5)c4)c3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(96)00248-X
10260012 109647 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 858 22 8 7 3.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
CHEMBL322391 109647 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8Concentration required to inhibit 50% of specific binding to Cholecystokinin type B receptor in guinea pig cortex using [125I]Bolton-Hunter CCK-8
ChEMBL 858 22 8 7 3.7 Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00028a015
10320031 77823 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
CHEMBL2092868 77823 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsDisplacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00121a004
44341613 9611 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 516 13 2 3 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccc(F)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL112622 9611 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 516 13 2 3 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccc(F)cc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
10553481 163281 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
CHEMBL418700 163281 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 8 3 8 4.5 CCOC(=O)c1ccccc1NC(=O)NNc1nc2ccccc2c(=O)n1-c1cccc(OC(C)C)c1 10.1021/jm970373j
73355866 206230 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
CHEMBL86702 206230 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Evaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of CCK-B receptor by displacing [125I]bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1021/jm00092a007
15673149 85990 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304151 85990 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 62 to 98
ChEMBL 717 13 5 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNS(=O)(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL3142697 211131 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL350222 211721 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortexIn vitro ability to inhibit [125I]Bolton-Hunter-CCK-8 binding to Cholecystokinin type B receptor in guinea pig cortex
ChEMBL None None None Cc1ccccc1NC(=O)N(C)CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00031a013
11801911 111513 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 613 8 1 5 6.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C2CCCC2)cc1 10.1021/jm970265x
CHEMBL327849 111513 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro for binding affinity against human cholecystokinin type B receptor.In vitro for binding affinity against human cholecystokinin type B receptor.
ChEMBL 613 8 1 5 6.4 COc1ccc(N(C(=O)CN2C(=O)C(Cc3n[nH]c4ccccc34)C(=O)N(c3ccccc3)c3ccccc32)C2CCCC2)cc1 10.1021/jm970265x
155532759 171753 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1431 50 12 15 5.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4467402 171753 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1431 50 12 15 5.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
16100410 141796 None 0 Human Binding pIC50 = 5.1 5.1 -7079 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL386212 141796 None 0 Human Binding pIC50 = 5.1 5.1 -7079 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44280315 101617 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL29891 101617 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 672 13 3 5 5.1 CN(Cc1ccccc1)C(=O)CC[C@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
44359338 168664 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
CHEMBL436411 168664 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 489 6 3 3 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1CC2CCC1C2 10.1021/jm970065l
44349102 168327 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 434 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL434250 168327 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 434 7 3 3 4.3 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44377852 165289 None 0 Human Binding pIC50 = 4.1 4.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 692 21 7 7 3.1 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
CHEMBL423260 165289 None 0 Human Binding pIC50 = 4.1 4.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 692 21 7 7 3.1 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)NCc1ccccc1 10.1021/jm00388a002
10252366 25882 None 14 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 434 3 2 3 4.8 CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL135364 25882 None 14 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 434 3 2 3 4.8 CN1C(=O)C(NC(=O)Nc2cccc3ccccc23)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44329325 161799 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3cccc(Cl)c3)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL414223 161799 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 594 7 3 3 7.2 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)Nc3cccc(Cl)c3)C2=O)c1 10.1016/S0960-894X(01)80832-5
44280266 98775 None 0 Human Binding pIC50 = 6.1 6.1 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL278217 98775 None 0 Human Binding pIC50 = 6.1 6.1 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 729 14 4 7 5.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
10555363 96485 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 588 9 1 4 6.6 CCC1(CC(=O)Nc2ccccc2)C(=O)N(CC(=O)N(c2ccccc2)C(C)C)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm960205b
CHEMBL262444 96485 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 588 9 1 4 6.6 CCC1(CC(=O)Nc2ccccc2)C(=O)N(CC(=O)N(c2ccccc2)C(C)C)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm960205b
44280508 99824 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
CHEMBL285559 99824 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 601 10 3 4 5.3 CC(Cc1ccccc1)(NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)O 10.1021/jm950372w
10392653 119039 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
CHEMBL342640 119039 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 544 5 2 5 3.4 CN1CCN(C(=O)CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)N=C(c3ccccc3)c3ccccc32)CC1 10.1016/S0960-894X(00)80683-6
10720107 206681 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(F)(F)F)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL8954 206681 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 497 6 3 6 5.3 CC(C)Oc1cccc(-n2c(NNC(=O)Nc3cccc(C(F)(F)F)c3)nc3ccccc3c2=O)c1 10.1021/jm970373j
10456021 207506 None 1 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
CHEMBL9449 207506 None 1 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
9868877 207664 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 460 8 2 4 3.8 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C)c2)c1 10.1021/jm970373j
CHEMBL9534 207664 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 460 8 2 4 3.8 COc1cccc(N(CC(=O)N(C)c2ccccc2)C(=O)CNC(=O)Nc2cccc(C)c2)c1 10.1021/jm970373j
135837528 120234 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3ncc[nH]3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
CHEMBL352217 120234 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Binding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligandBinding affinity towards gastrin/Cholecystokinin type B receptor from rat brain using [125I]CCK-8 as the radioligand
ChEMBL 472 5 3 5 3.7 Cc1cccc(NC(=O)NC2N=C(c3ncc[nH]3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1016/0960-894X(95)00557-A
155556375 174502 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)n1cc([C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
CHEMBL4554965 174502 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter methodDisplacement of [177Lu] PP-F11N from CCK2R (unknown origin) transfected in A431 cells incubated for 1 hr at 4 degree C followed by compound washout with PBS buffer using Lu3+ labeled compound by Cobra-2 gamma counter method
ChEMBL 1409 38 15 21 -2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)n1cc([C@@H](CCC(=O)O)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.9b01936
10456021 207506 None 1 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL9449 207506 None 1 Human Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 442 4 2 5 3.4 COC(=O)c1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00327-P
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00327-P
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a015
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligandIn vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]BH-CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a015
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80832-5
4627 821 None 50 Human Binding pIC50 = 8.1 8.1 -1 5
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
864 821 None 50 Human Binding pIC50 = 8.1 8.1 -1 5
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
9833444 821 None 50 Human Binding pIC50 = 8.1 8.1 -1 5
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
CHEMBL1121 821 None 50 Human Binding pIC50 = 8.1 8.1 -1 5
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
DB09142 821 None 50 Human Binding pIC50 = 8.1 8.1 -1 5
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL None None None None 10.1021/jm00173a006
44303527 96487 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
CHEMBL262456 96487 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 632 12 5 5 5.0 CC(Cc1c[nH]c2ccc(F)cc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(97)00356-9
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00032a002
5311201 207393 None 35 Mouse Binding pIC50 = 8.1 8.1 -26 6
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 8.1 8.1 -26 6
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970373j
CHEMBL2386886 210396 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Displacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assayDisplacement of Eu-DTPA-CCK8 from CCK2 receptor in HEK293 cells after 2 hrs by TRF assay
ChEMBL None None None C#CCCC(=O)NCCCC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cn(CC(=O)NCCC(=O)NCCC(=O)NCCCC(CCCNC(=O)CCNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)(NC(=O)CNC(=O)CCNC(=O)CCNC(=O)Cn2cc(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCC)N(C)C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCCNC(=O)CCC#C)NC(C)=O)nn2)C(=O)NCCC(N)=O)nn1 10.1016/j.bmcl.2013.02.022
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
In vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedIn vitro test for inhibition of [125I]CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determined
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(01)80987-2
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9506736
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesInhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9506736
5311201 207393 None 35 Mouse Binding pIC50 = 8.1 8.1 -26 6
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL9387 207393 None 35 Mouse Binding pIC50 = 8.1 8.1 -26 6
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(97)00108-X
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.Inhibitory activity against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00234-K
44376130 56334 None 0 Human Binding pIC50 = 8.1 8.1 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00032a003
CHEMBL163049 56334 None 0 Human Binding pIC50 = 8.1 8.1 - 0
The compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligandThe compound was tested for binding activity against Cholecystokinin type B receptor from rat pancreatic tissue using [125]BH CCK-8 as radioligand
ChEMBL 398 3 2 3 4.0 Cc1ccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)cc1 10.1021/jm00032a003
5311201 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
The concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membraneThe concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
CHEMBL9387 207393 None 35 Human Binding pIC50 = 8.1 8.1 -27 6
The concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membraneThe concentration required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pig cortical membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm9608523
145991539 166911 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2cccc(Br)c2)c1 10.1039/C7MD00171A
CHEMBL4286509 166911 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 509 5 4 6 4.2 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2cccc(Br)c2)c1 10.1039/C7MD00171A
44330874 208360 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 2.1 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N/C(=C\c1ccccc1)C(N)=O 10.1021/jm00094a001
CHEMBL99499 208360 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Evaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortexEvaluated in vitro for its binding affinity towards cholecystokinin type B receptor of guinea pig cortex
ChEMBL 974 28 10 11 2.1 CCCC[C@H](NC(=O)CCc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N/C(=C\c1ccccc1)C(N)=O 10.1021/jm00094a001
14802508 78789 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 615 12 4 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(OC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
CHEMBL2112695 78789 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptorHalf-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor
ChEMBL 615 12 4 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(OC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00105a062
10325557 46506 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 563 9 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL153760 46506 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 563 9 4 4 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2Cl)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
73355867 206258 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 680 12 5 6 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1ccccc1O)c1ccccc1 10.1021/jm00092a007
CHEMBL86879 206258 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
ChEMBL 680 12 5 6 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@@H](NC(=O)CSc1ccccc1O)c1ccccc1 10.1021/jm00092a007
10102593 141503 None 2 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
CHEMBL384505 141503 None 2 Human Binding pIC50 = 7.1 7.1 - 0
In vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranesIn vitro binding affinity against Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 1048 29 10 12 3.3 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80679-4
44329304 108116 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 7 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
CHEMBL319569 108116 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 526 7 3 3 5.5 Cc1cccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)C)C2=O)c1 10.1016/S0960-894X(01)80832-5
44279861 103182 None 0 Human Binding pIC50 = 7.1 7.1 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL30821 103182 None 0 Human Binding pIC50 = 7.1 7.1 - 1
Inhibitory activity against gastrin receptorInhibitory activity against gastrin receptor
ChEMBL 726 14 6 9 3.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCC(=O)NCCSCc3csc(N=C(N)N)n3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44327455 107343 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 12 3 4 6.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317626 107343 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 585 12 3 4 6.0 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCCC(=O)O)CCc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL34916 211715 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cellsBinding affinity towards Cholecystokinin type B receptor by displacement of [125I]BH-CCK-8 from human jurkat cells
ChEMBL None None None CCS[C@@H]1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(C)=O)[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00001a019
44349070 164489 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL421438 164489 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 421 7 3 4 3.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
14208241 67749 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907852 67749 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 421 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208269 77824 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL2092869 77824 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 447 3 1 3 4.0 CN1C(=O)[C@@H](NC(=O)c2ccc(Br)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
44349064 16518 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 435 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL123684 16518 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 435 7 3 4 3.4 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44348870 114826 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 452 7 3 5 3.3 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
CHEMBL334171 114826 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 452 7 3 5 3.3 O=C(O)CCC(NC(=O)c1cnc2ccccc2c1)C(=O)NN1CCC2(CCCCC2)CC1 10.1021/jm00079a003
44349336 164512 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1Cl)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
CHEMBL421474 164512 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 455 7 3 4 3.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1Cl)C(=O)NN1CCC2(CCCC2)CC1 10.1021/jm00079a003
44280200 100822 None 0 Mouse Binding pIC50 = 6.1 6.1 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
CHEMBL29331 100822 None 0 Mouse Binding pIC50 = 6.1 6.1 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.6 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)C2=O)c1 10.1016/S0960-894X(96)00248-X
5279366 104159 None 1 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 401 4 2 4 4.0 CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL309575 104159 None 1 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 401 4 2 4 4.0 CSc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
15104601 170427 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
CHEMBL444847 170427 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 486 13 3 2 6.2 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc2ccccc2[nH]1 10.1021/jm00116a002
44349073 16555 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 395 7 3 4 2.5 CC1(C)CCN(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
CHEMBL123785 16555 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 395 7 3 4 2.5 CC1(C)CCN(NC(=O)C(CCC(=O)O)NC(=O)c2cccc(Cl)c2)CC1 10.1021/jm00079a003
14208261 103685 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 397 5 2 3 4.2 CCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
CHEMBL308756 103685 None 0 Human Binding pIC50 = 4.1 4.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 397 5 2 3 4.2 CCCc1ccc(C(=O)NC2N=C(c3ccccc3)c3ccccc3NC2=O)cc1 10.1021/jm00120a002
44379640 57584 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 522 6 2 5 5.8 CC(C)Oc1cccc(-n2c(C/N=C(\S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL166737 57584 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 522 6 2 5 5.8 CC(C)Oc1cccc(-n2c(C/N=C(\S)Nc3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
4355450 135925 None 50 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37312 135925 None 50 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranesInhibition of [125I]-labeled CCK-8 sulfate binding to Cholecystokinin type B receptor in guinea pig brain membranes
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
10070677 161722 None 15 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL41361 161722 None 15 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2ccc(Cl)cc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44382244 59193 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 618 11 4 4 6.4 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)Nc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL170129 59193 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 618 11 4 4 6.4 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)Nc1ccccc1 10.1016/S0960-894X(00)80687-3
44334338 108911 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 547 9 2 5 4.2 Cc1cccc(NC(=O)N[C@H](CS(=O)(=O)Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL321107 108911 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 547 9 2 5 4.2 Cc1cccc(NC(=O)N[C@H](CS(=O)(=O)Cc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
44349383 16765 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL124396 16765 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 480 9 3 3 4.7 O=C(O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
44348869 16405 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 407 7 3 4 2.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)C1 10.1021/jm00079a003
CHEMBL123089 16405 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 407 7 3 4 2.6 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)C1 10.1021/jm00079a003
44377487 120159 None 0 Human Binding pIC50 = 4.1 4.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 691 22 6 7 3.3 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
CHEMBL351531 120159 None 0 Human Binding pIC50 = 4.1 4.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 691 22 6 7 3.3 CCCCOC(=O)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)CCc1ccccc1 10.1021/jm00388a002
10074366 120596 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 120596 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 120596 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
44386584 166361 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
CHEMBL427492 166361 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 573 8 4 5 3.2 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CCCN2C(=O)[C@](Cc3ccccc3)(C(N)=O)C[C@H]12 10.1016/0960-894X(96)00160-6
136794946 106610 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
15689731 106610 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL3142903 106610 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortexDisplacement of [125I]- BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm960509y
CHEMBL355778 211738 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](CCc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
14208247 204649 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 5 2 4 3.5 O=C(O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL73621 204649 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 465 5 2 4 3.5 O=C(O)CN1C(=O)C(NC(=O)c2ccc(Cl)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14208245 204757 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
CHEMBL74580 204757 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 389 3 2 3 3.9 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(Cl)cc1 10.1021/jm00120a002
44382243 59520 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 632 12 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCc1ccccc1 10.1016/S0960-894X(00)80687-3
CHEMBL171562 59520 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 632 12 4 4 6.1 O=C(CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1)NCc1ccccc1 10.1016/S0960-894X(00)80687-3
14843033 136953 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL37439 136953 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptorInhibition of [125I]-labeled gastrin binding to gastrin/cholecystokinin type B receptor
ChEMBL 433 4 1 3 5.7 O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1cccc(C(F)(F)F)c1 10.1021/jm00108a040
CHEMBL286843 100020 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 541 8 3 4 7.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C1NC=C(CCc2ccccc2)S1 10.1021/jm00086a017
10673570 30154 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(C(=O)O)CCCCC1 10.1021/jm970065l
CHEMBL139001 30154 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 521 7 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC1(C(=O)O)CCCCC1 10.1021/jm970065l
14991575 100782 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 852 20 10 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(O)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL293026 100782 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 852 20 10 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1cc2cc(O)ccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44349082 17773 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
CHEMBL125874 17773 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric glandConcentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland
ChEMBL 446 9 3 3 4.0 O=C(O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2 10.1021/jm00079a003
10698109 107294 None 0 Human Binding pIC50 = 6.1 6.1 -5 2
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL317181 107294 None 0 Human Binding pIC50 = 6.1 6.1 -5 2
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
10698109 107294 None 0 Human Binding pIC50 = 6.1 6.1 -5 2
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
CHEMBL317181 107294 None 0 Human Binding pIC50 = 6.1 6.1 -5 2
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
10031013 206482 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Cholecystokinin type B receptorBinding affinity against human Cholecystokinin type B receptor
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
CHEMBL88239 206482 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Cholecystokinin type B receptorBinding affinity against human Cholecystokinin type B receptor
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960249k
10031013 206482 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL88239 206482 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
155530671 171560 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1627 65 14 19 4.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4464703 171560 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1627 65 14 19 4.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)NC(=O)Cc1ccc(O)cc1)C(=O)N(C)[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
10031013 206482 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
CHEMBL88239 206482 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assayDisplacement of [125I]Bolton-Hunter CCK8 from human Cholecystokinin B receptor expressed in CHO-K1 cells by competitive radioligand binding assay
ChEMBL 574 8 1 4 6.2 CC(C)N(C(=O)CN1C(=O)C(C)(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/acs.jmedchem.0c00829
14991580 100706 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 829 21 8 9 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccs1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL292490 100706 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 829 21 8 9 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccs1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44280598 100491 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
CHEMBL291001 100491 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortexInhibition of binding of [3H]N-Me-N-Leu-CCK-8 to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 694 12 4 5 6.2 O=C(O)CC[C@@H](NC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)N1CCC2(CCCC2)CC1)C(=O)Nc1cccc2ccccc12 10.1021/jm950372w
15689725 106600 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142704 106600 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 880 20 9 8 4.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
44366587 43690 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uM
ChEMBL 554 10 0 8 7.2 CCOP(=O)(OCC)OC1=CCN(Cc2ccccc2)CC1Cc1cn(C(=O)OC(C)(C)C)c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL151022 43690 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Binding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uMBinding affinity towards CCK-B receptor in mouse cerebral cortex using [125I]Bolton-Hunter CCK-8 as radioligand; Value ranges from 7.8-9.3 uM
ChEMBL 554 10 0 8 7.2 CCOP(=O)(OCC)OC1=CCN(Cc2ccccc2)CC1Cc1cn(C(=O)OC(C)(C)C)c2ccccc12 10.1016/0960-894X(94)80030-8
10165354 22144 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590
ChEMBL 529 9 4 4 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
CHEMBL132233 22144 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590Evaluated for in vitro binding affinity towards cholecystokinin-B (CCK-B) receptor in mouse cerebral cortex using [125I]bolton hunter CCK-26-33 as radioligand; 365-1590
ChEMBL 529 9 4 4 4.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC(CO)Cc1ccccc1 10.1016/S0960-894X(00)80156-0
11741582 27959 None 9 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 4 2 3 3.3 CN1C(=O)C(NC(=O)NCc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137213 27959 None 9 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 398 4 2 3 3.3 CN1C(=O)C(NC(=O)NCc2ccccc2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44370461 119564 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
CHEMBL346070 119564 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glandsInhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands
ChEMBL 488 15 2 4 4.8 CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)N1CCCC1)NC(=O)Nc1cccc(OC)c1 10.1021/jm00164a020
19766170 59155 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL169931 59155 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 383 5 3 4 2.2 COc1cccc(NC(=O)NC2CCc3ccccc3N(CC(=O)O)C2=O)c1 10.1016/S0960-894X(00)80683-6
44381609 129110 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 610 15 6 7 2.5 N#C[C@H](N[C@H](CC(=O)NC(Cc1ccccc1)C(N)=O)C(=O)O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00107-8
CHEMBL367057 129110 None 0 Rat Binding pIC50 = 5.1 5.1 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 610 15 6 7 2.5 N#C[C@H](N[C@H](CC(=O)NC(Cc1ccccc1)C(N)=O)C(=O)O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/S0960-894X(97)00107-8
14991578 161713 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 824 21 8 9 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccnc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL413548 161713 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 824 21 8 9 2.7 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1cccnc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44329343 112328 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1016/S0960-894X(01)80832-5
CHEMBL329286 112328 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.
ChEMBL 556 7 3 4 5.6 COc1ccc(NC(=O)N[C@@H]2C[C@H](c3ccccc3C)C[C@H](c3ccccc3)N(CC(=O)NC(C)(C)C)C2=O)cc1 10.1016/S0960-894X(01)80832-5
155537344 172316 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1848 72 16 22 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
CHEMBL4475304 172316 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assayDisplacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay
ChEMBL 1848 72 16 22 3.6 CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01558
44303481 100697 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 524 9 3 6 4.3 CC(=O)Nc1nc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)NCCc2ccccc2)cs1 10.1016/S0960-894X(97)00356-9
CHEMBL292422 100697 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortexInhibition of binding of [125I]- Bolton-Hunter labeled CCK-8 to CCK-B receptor in the mouse cerebral cortex
ChEMBL 524 9 3 6 4.3 CC(=O)Nc1nc(CC(C)(NC(=O)OC2C3CC4CC(C3)CC2C4)C(=O)NCCc2ccccc2)cs1 10.1016/S0960-894X(97)00356-9
44382057 120333 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
CHEMBL352939 120333 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.Ability to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 420 4 2 3 3.1 Cc1cccc(NC(=O)N[C@H]2CCc3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1016/S0960-894X(00)80683-6
44379911 58871 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 442 6 2 5 4.8 Cc1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
CHEMBL168875 58871 None 0 Mouse Binding pIC50 = 6.1 6.1 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 442 6 2 5 4.8 Cc1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC(C)C)c2)c1 10.1016/S0960-894X(97)00108-X
10553207 208270 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 492 6 2 6 4.7 CC(C)Oc1cccc(-n2c(NNC(=O)c3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9888 208270 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 492 6 2 6 4.7 CC(C)Oc1cccc(-n2c(NNC(=O)c3ccc(Br)cc3)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL2112689 209247 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligandBinding affinity towards Cholecystokinin type B receptor was determined in guinea pig cortex using [3H]SNF8702 as radioligand
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)c1c[nH]c2ccccc12 10.1021/jm960078j
14843047 119499 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 487 6 1 4 5.8 CCOc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
CHEMBL34547 119499 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 487 6 1 4 5.8 CCOc1ccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)cc1 10.1021/jm00108a040
44333312 4569 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 406 2 3 5 1.8 Cc1cccc(NC(=O)NC2N=C(N3CCNCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
CHEMBL102537 4569 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 406 2 3 5 1.8 Cc1cccc(NC(=O)NC2N=C(N3CCNCC3)c3ccccc3N(C)C2=O)c1 10.1016/0960-894X(95)00530-0
44152863 120361 None 7 Mouse Binding pIC50 = 6.1 6.1 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
CHEMBL353189 120361 None 7 Mouse Binding pIC50 = 6.1 6.1 - 0
The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in mouse brain at a pH of 7.4
ChEMBL 475 3 2 2 5.9 O=C1NN(C(=S)Nc2ccc(Cl)c(C(F)(F)F)c2)C(c2ccccc2)C1c1ccccc1 10.1016/S0960-894X(00)80684-8
15673150 85992 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
CHEMBL2304154 85992 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170The concentration (nM) producing half-maximal inhibition of specific binding of [1251] Bolton Hunter CCK-8 to CCK receptors in the mouse cerebral cortex (CCK-B);value ranges from 63 to 170
ChEMBL 681 12 5 5 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCNC(=O)C(F)(F)F)c1ccccc1 10.1016/S0960-894X(00)80652-6
44382749 59707 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 532 11 4 4 3.0 CC(C)C[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
CHEMBL172354 59707 None 0 Mouse Binding pIC50 = 5.1 5.1 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL 532 11 4 4 3.0 CC(C)C[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@H](Cc2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
10580108 5109 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 650 10 1 4 7.4 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)(Cc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
CHEMBL105619 5109 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligandBinding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand
ChEMBL 650 10 1 4 7.4 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)(Cc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1021/jm960205b
44300888 100789 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 6 4 6 4.5 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(-c4nn[nH]n4)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1016/0960-894X(95)00327-P
CHEMBL293107 100789 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexBinding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortex
ChEMBL 580 6 4 6 4.5 Cc1ccc([C@H]2C[C@@H](NC(=O)Nc3cccc(-c4nn[nH]n4)c3)C(=O)N(CC(=O)NC(C)(C)C)c3cc(C)ccc32)cc1 10.1016/0960-894X(95)00327-P
73349872 89199 None 1 Rat Binding pIC50 = 8.1 8.1 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/0960-894X(96)00160-6
CHEMBL2367718 89199 None 1 Rat Binding pIC50 = 8.1 8.1 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/0960-894X(96)00160-6
CHEMBL2367719 89199 None 1 Rat Binding pIC50 = 8.1 8.1 - 0
Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.Binding of [3H]propionyl-CCK-8 to Cholecystokinin type B receptor from rat cerebral cortex.
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1016/0960-894X(96)00160-6
44348637 164508 None 0 Bovine Binding pIC50 = 8.1 8.1 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 966 27 11 11 1.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
CHEMBL421471 164508 None 0 Bovine Binding pIC50 = 8.1 8.1 - 0
Inhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatumInhibition of [3H]propionyl-CCK-8 binding to Cholecystokinin type B receptor in bovine striatum
ChEMBL 966 27 11 11 1.0 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCNC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a005
44281204 99848 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL285719 99848 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Inhibitory activity against gastrin receptor.Inhibitory activity against gastrin receptor.
ChEMBL 871 18 4 10 5.5 CN1C(=O)[C@H](NC(=O)Nc2cccc(COC(=O)NCCCN3CCN(C(=O)CNCCCOc4cccc(CN5CCCCC5)c4)CC3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
44265968 206786 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
CHEMBL9026 206786 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4cc(Br)ccc34)nc3ccccc3c2=O)c1 10.1021/jm970373j
4355450 135925 None 50 Mouse Binding pIC50 = 8.0 8.0 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL37312 135925 None 50 Mouse Binding pIC50 = 8.0 8.0 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
5311347 107354 None 3 Mouse Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
CHEMBL317675 107354 None 3 Mouse Binding pIC50 = 8.0 8.0 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(01)80769-1
4355450 135925 None 50 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
CHEMBL37312 135925 None 50 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexInhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortex
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1016/S0960-894X(97)00108-X
4355450 135925 None 50 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
CHEMBL37312 135925 None 50 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.Inhibition of [125I]CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.
ChEMBL 501 6 1 4 6.2 CC(C)Oc1cccc(-n2c(CCc3c[nH]c4ccc(Br)cc34)nc3ccccc3c2=O)c1 10.1021/jm00108a040
5311347 33024 None 3 Mouse Binding pIC50 = 8.0 8.0 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
CHEMBL141630 33024 None 3 Mouse Binding pIC50 = 8.0 8.0 - 1
Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.Inhibition of [125I]CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1016/S0960-894X(00)80685-X
5311347 107354 None 3 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
CHEMBL317675 107354 None 3 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00057a005
10074366 120596 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3349028 120596 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
CHEMBL3545866 120596 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 491 9 4 4 4.5 C[C@H]1CCCC[C@@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00057a005
5311347 33024 None 3 Mouse Binding pIC50 = 8.0 8.0 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm970065l
CHEMBL141630 33024 None 3 Mouse Binding pIC50 = 8.0 8.0 - 1
Inhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortexInhibitory concentration against radioligand [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm970065l
9823890 26932 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 4 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL136412 26932 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 428 4 3 4 3.3 CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
10412837 27621 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 479 5 3 5 4.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3n[nH]c(C)n3)C2=O)c1 10.1021/jm00078a018
CHEMBL136975 27621 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 479 5 3 5 4.0 Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(Cc3n[nH]c(C)n3)C2=O)c1 10.1021/jm00078a018
44357031 28696 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 585 8 2 9 3.1 COC(=O)[C@H]1CCCN1OC(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137779 28696 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 585 8 2 9 3.1 COC(=O)[C@H]1CCCN1OC(=O)CN1C(=O)C(NC(=O)Nc2cccc(OC)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
145980742 166529 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)cc1 10.1039/C7MD00171A
CHEMBL4279247 166529 None 0 Rat Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 465 6 3 6 4.8 CCOc1ccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)cc2)cc1 10.1039/C7MD00171A
21467078 4423 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
CHEMBL101528 4423 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexDisplacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortex
ChEMBL 448 4 2 5 2.9 CCCN1C(=O)C(NC(=O)Nc2cccc(C)c2)N=C(N2CCN(C)CC2)c2ccccc21 10.1016/0960-894X(95)00530-0
73349872 89199 None 1 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm0498755
CHEMBL2367718 89199 None 1 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm0498755
CHEMBL2367719 89199 None 1 Rat Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenatesInhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm0498755
10070679 27766 None 13 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
CHEMBL137066 27766 None 13 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 418 3 2 3 4.3 CN1C(=O)C(NC(=O)Nc2cccc(Cl)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm00078a018
44377486 168266 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O 10.1021/jm00388a002
CHEMBL433901 168266 None 0 Human Binding pIC50 = 7.1 7.1 - 0
In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.In vitro inhibitory activity for binding of [125I](Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.
ChEMBL 678 16 7 7 2.5 CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@H](CC(=O)O)NC(=O)C(Cc1ccccc1)C(N)=O 10.1021/jm00388a002
44327698 207471 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 572 10 2 6 4.7 COC(=O)CN(CCc1ccccn1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
CHEMBL94298 207471 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.In vitro inhibition of [125I]- Bolton Hunter CCK-8 binding to Cholecystokinin type B receptor in the mouse cerebral cortex.
ChEMBL 572 10 2 6 4.7 COC(=O)CN(CCc1ccccn1)C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1016/S0960-894X(01)80769-1
44349413 113105 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 410 12 3 3 4.0 CCC(CC)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
CHEMBL331413 113105 None 0 Rat Binding pIC50 = 6.1 6.1 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 410 12 3 3 4.0 CCC(CC)(CC)CCNC(=O)C(CCC(=O)O)NC(=O)c1cccc(Cl)c1 10.1021/jm00079a003
44334337 4673 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 541 10 2 5 5.1 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
CHEMBL103276 4673 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 541 10 2 5 5.1 Cc1cccc(NC(=O)N[C@H](CCC(=O)OCc2ccccc2)C(=O)N2CCC(C(=O)c3ccccc3)CC2)c1 10.1016/0960-894X(95)00537-3
14208302 67743 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 1 4 3.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
CHEMBL1907847 67743 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 412 3 1 4 3.3 CN1C(=O)[C@@H](NC(=O)c2ccc(C#N)cc2)N=C(c2ccccc2F)c2ccccc21 10.1021/jm00120a002
14994682 206058 None 0 Mouse Binding pIC50 = 5.0 5.0 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(C(C)Cc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
CHEMBL85393 206058 None 0 Mouse Binding pIC50 = 5.0 5.0 - 0
Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)Evaluated for inhibition of [125I]CCK-8S binding to cholecystokinin CCK-B receptor from mouse brain membranes at a concentration of 10 uM (in vitro)
ChEMBL 437 6 1 4 6.0 CC(C)Oc1cccc(-n2c(C(C)Cc3c[nH]c4ccccc34)nc3ccccc3c2=O)c1 10.1021/jm00092a003
44333997 108757 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 588 10 3 5 5.3 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
CHEMBL320886 108757 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissueInhibitory activity towards binding of [125I]Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue
ChEMBL 588 10 3 5 5.3 CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/0960-894X(95)00537-3
10644845 96991 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 403 4 3 5 4.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
CHEMBL266523 96991 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 403 4 3 5 4.0 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2cccc(F)c2)c1 10.1021/jm970373j
CHEMBL2079550 209191 None 0 Bovine Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranesInhibition of [3H]-propanoyl binding to cholecystokinin type B receptor subtype was determined in bovine striatum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(C(F)(F)C(=O)O)cc1)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00107a037
10046475 115505 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
CHEMBL335241 115505 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorInhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptor
ChEMBL 399 3 2 4 3.4 Cc1cccc(NC(=O)NC2N=C(c3cccnc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00078a018
44279809 98965 None 0 Mouse Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
CHEMBL279778 98965 None 0 Mouse Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 785 18 4 7 6.4 CN1C(=O)[C@H](NC(=O)Nc2cccc(CC(=O)NCCCCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00248-X
44381820 120622 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL354631 120622 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 689 18 7 8 2.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)[C@@H](C#N)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
15104628 10003 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 534 10 2 5 4.6 CCOC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
CHEMBL114926 10003 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 534 10 2 5 4.6 CCOC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cnc2ccccc2c1 10.1021/jm00116a002
15104621 111356 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
CHEMBL326975 111356 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 476 13 3 2 6.4 CCCCCN(CCCCC)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(C)cc1 10.1021/jm00116a002
CHEMBL282175 99319 None 0 Mouse Binding pIC50 = 6.0 6.0 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 769 16 6 11 4.6 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCSCc3csc(C=C(N)N)n3)C2=O)c1 10.1016/S0960-894X(96)00249-1
44408483 168927 None 0 Human Binding pIC50 = 6.0 6.0 -275 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL438739 168927 None 0 Human Binding pIC50 = 6.0 6.0 -275 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
44408484 137506 None 0 Human Binding pIC50 = 5.0 5.0 -18197 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL375412 137506 None 0 Human Binding pIC50 = 5.0 5.0 -18197 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
44418924 156880 None 0 Human Binding pIC50 = 5.0 5.0 -18620 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 156880 None 0 Human Binding pIC50 = 5.0 5.0 -18620 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
11714636 141236 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
CHEMBL382952 141236 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2
ChEMBL 717 10 6 6 3.7 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1C[C@@H]2c3[nH]c4ccccc4c3C[C@@H](C(=O)N[C@H](Cc3ccccc3)C(N)=O)N2C1=O 10.1021/jm050689o
44381851 120376 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
CHEMBL353305 120376 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(=O)O 10.1016/S0960-894X(97)00107-8
44281078 99741 None 0 Mouse Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL284975 99741 None 0 Mouse Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 773 16 4 8 5.9 CN1C(=O)[C@H](NC(=O)Nc2cccc(CCOC(=O)NCCC(=O)NCCCOc3cccc(CN4CCCCC4)c3)c2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00249-1
CHEMBL172635 208852 None 0 Mouse Binding pIC50 = 5.0 5.0 - 0
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors mouse forebrain membranes (CCK-B)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1C[C@H](c2ccccc2)NC(=O)[C@@H]1CC(=O)O 10.1016/S0960-894X(01)80253-5
14208258 102954 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 10.1021/jm00120a002
CHEMBL306394 102954 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 373 3 2 3 3.4 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1ccc(F)cc1 10.1021/jm00120a002
613843 204577 None 31 Human Binding pIC50 = 4.0 4.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 250 1 0 2 2.5 CN1C(=O)CN=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
CHEMBL73096 204577 None 31 Human Binding pIC50 = 4.0 4.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 250 1 0 2 2.5 CN1C(=O)CN=C(c2ccccc2)c2ccccc21 10.1021/jm00120a002
14208248 204639 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 441 3 2 3 4.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
CHEMBL73561 204639 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glandsHalf-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
ChEMBL 441 3 2 3 4.4 O=C(NC1N=C(c2ccccc2F)c2ccccc2NC1=O)c1ccc(C(F)(F)F)cc1 10.1021/jm00120a002
44381819 58613 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
CHEMBL168435 58613 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptorInhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane Cholecystokinin type B receptor
ChEMBL 723 20 7 8 3.2 CCCC[C@H](N[C@@H](C#N)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(97)00107-8
44349164 18543 None 0 Rat Binding pIC50 = 4.0 4.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 320 10 3 3 2.0 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
CHEMBL127551 18543 None 0 Rat Binding pIC50 = 4.0 4.0 - 0
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
ChEMBL 320 10 3 3 2.0 CCCCCNC(=O)C(CCC(=O)O)NC(=O)c1ccccc1 10.1021/jm00079a003
10742340 207667 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
CHEMBL9535 207667 None 0 Mouse Binding pIC50 = 7.0 7.0 - 0
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]bolton Hunter CCK-8 as radioligand
ChEMBL 453 4 3 5 5.2 Cc1cccc(NC(=O)NNc2nc3ccccc3c(=O)n2-c2ccc(Cl)c(Cl)c2)c1 10.1021/jm970373j
90663975 106796 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144537 106796 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 839 21 9 9 3.0 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C\c1cccc(O)c1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
15104607 163411 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc2ccccc12 10.1021/jm00116a002
CHEMBL419585 163411 None 0 Human Binding pIC50 = 5.0 5.0 - 0
Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.Inhibition of [125I]Bolton-Hunter CCK-8 binding to cholecystokinin type B receptor in guinea pig cerebral cortical.
ChEMBL 497 13 2 2 6.9 CCCCCN(CCCCC)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cccc2ccccc12 10.1021/jm00116a002
145987307 167099 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 431 5 4 6 3.4 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1039/C7MD00171A
CHEMBL4289939 167099 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Displacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting methodDisplacement of [125I]-BH-CCK-8 from CCK-B receptor in rat cerebral cortex plasma membrane after 1 hr by liquid scintillation counting method
ChEMBL 431 5 4 6 3.4 O=C(O)c1cccc(NC(=S)NNc2nc3ccccc3c(=O)n2-c2ccccc2)c1 10.1039/C7MD00171A
15177358 52940604 16528 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 667 9 4 4 7.1 ClC(Cl)(Cl)Cl.O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
CHEMBL1237153 16528 None 0 Mouse Binding pIC50 = 6.0 6.0 - 0
Inhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortexInhibition of [125I]CCK-8 binding to cholecystokinin type B receptor in the mouse cerebral cortex
ChEMBL 667 9 4 4 7.1 ClC(Cl)(Cl)Cl.O=C(NC(Cc1c[nH]c2ccccc12)NC(=O)C(CO)Cc1ccccc1)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00086a017
44386048 61515 None 0 Mouse Binding pIC50 = 7 7.0 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
CHEMBL177081 61515 None 0 Mouse Binding pIC50 = 7 7.0 - 0
Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.Compound measured for half-maximal inhibition of specific binding of [125I]bolton Hunter CCK-26-33 to CCK-B receptor in the mouse cerebral cortex.
ChEMBL 541 9 4 4 5.3 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)/C(=C/c1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/S0960-894X(00)80273-5
136794946 106610 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
15689731 106610 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
CHEMBL3142903 106610 None 0 Human Binding pIC50 = 6 6.0 - 0
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligandBinding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]BH-CCK-8 as radioligand
ChEMBL 857 21 9 10 3.2 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1[N+](=O)[O-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00113a023
14991541 106806 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 843 22 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
CHEMBL3144546 106806 None 0 Human Binding pIC50 = 5 5.0 - 0
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortexInhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex
ChEMBL 843 22 8 8 3.3 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCc1ccc(F)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00089a010
44382456 120459 None 0 Human Binding pKd = 10.0 10.0 1 3
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/0960-894X(95)00435-V
CHEMBL354049 120459 None 0 Human Binding pKd = 10.0 10.0 1 3
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/0960-894X(95)00435-V
CHEMBL83942 120459 None 0 Human Binding pKd = 10.0 10.0 1 3
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/0960-894X(95)00435-V
44318341 205997 None 0 Human Binding pKd = 9.6 9.6 1 3
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL1628582 205997 None 0 Human Binding pKd = 9.6 9.6 1 3
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL84864 205997 None 0 Human Binding pKd = 9.6 9.6 1 3
The equilibrium binding constant to guinea pig cerebral cortex membranes was measuredThe equilibrium binding constant to guinea pig cerebral cortex membranes was measured
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL413654 213077 None 0 Rat Binding pKd = 8.9 8.9 2 2
Tested in vitro by the gastrin binding assay for the competitive binding with iodinated gastrin for the gastrin receptors in AR42J cellsTested in vitro by the gastrin binding assay for the competitive binding with iodinated gastrin for the gastrin receptors in AR42J cells
ChEMBL None None None CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
10075052 189672 None 0 Human Binding pKd = 8.5 8.5 -10 2
Binding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assayBinding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assay
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515268 189672 None 0 Human Binding pKd = 8.5 8.5 -10 2
Binding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assayBinding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assay
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515288 189672 None 0 Human Binding pKd = 8.5 8.5 -10 2
Binding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assayBinding affinity to human CCK2 receptor expressed in CHO cell membrane by saturation binding assay
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL120632 208603 None 33 Human Binding pKd = 7.7 7.7 5 3
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
145978895 166463 None 0 Human Binding pKd = 7.5 7.5 - 1
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4278080 166463 None 0 Human Binding pKd = 7.5 7.5 - 1
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL413654 213077 None 0 Human Binding pKd = 8.5 8.5 -2 2
Tested in vitro for gastrin binding to gastrin receptors from guinea pig gastric glandsTested in vitro for gastrin binding to gastrin receptors from guinea pig gastric glands
ChEMBL None None None CSCC[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00048a016
145991328 166905 None 0 Human Binding pKd = 7.3 7.3 - 1
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4286411 166905 None 0 Human Binding pKd = 7.3 7.3 - 1
Binding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisBinding affinity to CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
44461961 105607 None 0 Human Binding pKd = 8.1 8.1 -9 3
The equilibrium binding constant to pig cerebral cortex membranes was measuredThe equilibrium binding constant to pig cerebral cortex membranes was measured
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL2079605 105607 None 0 Human Binding pKd = 8.1 8.1 -9 3
The equilibrium binding constant to pig cerebral cortex membranes was measuredThe equilibrium binding constant to pig cerebral cortex membranes was measured
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL312252 105607 None 0 Human Binding pKd = 8.1 8.1 -9 3
The equilibrium binding constant to pig cerebral cortex membranes was measuredThe equilibrium binding constant to pig cerebral cortex membranes was measured
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
25193919 189056 None 0 Human Binding pKi = 10.7 10.7 - 1
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL509524 189056 None 0 Human Binding pKi = 10.7 10.7 - 1
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
44580932 173468 None 0 Human Binding pKi = 10.4 10.4 -1 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
CHEMBL452991 173468 None 0 Human Binding pKi = 10.4 10.4 -1 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 617 14 6 10 -1.5 CNC(=O)COCC(=O)NCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2(O)[C@H]3Cc4cc(O)cc5c4[C@@]2(CCN3C)[C@H]1O5 10.1021/jm800174p
25193919 189056 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL509524 189056 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 786 22 6 10 1.7 CNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)NCCOc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL1206334 208604 None 0 Human Binding pKi = 10.2 10.2 1023 2
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
CHEMBL262894 208604 None 0 Human Binding pKi = 10.2 10.2 1023 2
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
887 4108 None 33 Human Binding pKi = 10.1 10.1 -1 4
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
9870520 4108 None 33 Human Binding pKi = 10.1 10.1 -1 4
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
CHEMBL324547 4108 None 33 Human Binding pKi = 10.1 10.1 -1 4
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
DB12355 4108 None 33 Human Binding pKi = 10.1 10.1 -1 4
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1016/j.bmc.2007.12.047
135423404 85510 None 0 Human Binding pKi = 10.0 10.0 16 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL227276 85510 None 0 Human Binding pKi = 10.0 10.0 16 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 8 2 7 5.0 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(-c2noc(=O)[nH]2)c1 10.1021/jm070139l
CHEMBL2372781 210286 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCC)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(S(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)O 10.1021/jm00053a022
887 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
9870520 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
CHEMBL324547 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
DB12355 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm051219x
887 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
9870520 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
CHEMBL324547 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
DB12355 4108 None 33 Human Binding pKi = 9.9 9.9 -1 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 10.1021/jm070139l
903 3022 None 9 Mouse Binding pKi = 9.8 9.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
9850711 3022 None 9 Mouse Binding pKi = 9.8 9.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL138534 3022 None 9 Mouse Binding pKi = 9.8 9.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL2111312 3022 None 9 Mouse Binding pKi = 9.8 9.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@@H](NC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL411271 212873 None 0 Human Binding pKi = 9.8 9.8 2 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL384035 212314 None 4 Human Binding pKi = 9.8 9.8 8 4
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
CHEMBL428666 212314 None 4 Human Binding pKi = 9.8 9.8 8 4
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
44346225 161907 None 0 Human Binding pKi = 9.8 9.8 12022 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 3 4 5.6 O=C(Nc1cccc(CO)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL415240 161907 None 0 Human Binding pKi = 9.8 9.8 12022 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 3 4 5.6 O=C(Nc1cccc(CO)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
135610887 85440 None 0 Human Binding pKi = 9.7 9.7 22 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226583 85440 None 0 Human Binding pKi = 9.7 9.7 22 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44382456 120459 None 0 Mouse Binding pKi = 9.7 9.7 -1 3
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/S0960-894X(00)80686-1
CHEMBL354049 120459 None 0 Mouse Binding pKi = 9.7 9.7 -1 3
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/S0960-894X(00)80686-1
CHEMBL83942 120459 None 0 Mouse Binding pKi = 9.7 9.7 -1 3
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in mouse cortex.
ChEMBL 572 10 5 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)cc1 10.1016/S0960-894X(00)80686-1
9958214 114791 None 0 Human Binding pKi = 9.7 9.7 269 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL333979 114791 None 0 Human Binding pKi = 9.7 9.7 269 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL382409 212304 None 0 Human Binding pKi = 9.7 9.7 6918 2
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44346047 113400 None 0 Human Binding pKi = 9.7 9.7 537 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 568 7 2 7 6.4 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
CHEMBL331872 113400 None 0 Human Binding pKi = 9.7 9.7 537 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 568 7 2 7 6.4 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
CHEMBL384035 212314 None 4 Human Binding pKi = 9.6 9.6 8 4
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL428666 212314 None 4 Human Binding pKi = 9.6 9.6 8 4
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16732162 142091 None 0 Human Binding pKi = 9.6 9.6 1862 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 584 8 2 6 6.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3ccc(C(=O)O)o3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL388144 142091 None 0 Human Binding pKi = 9.6 9.6 1862 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 584 8 2 6 6.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3ccc(C(=O)O)o3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9958214 114791 None 0 Human Binding pKi = 9.6 9.6 269 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL333979 114791 None 0 Human Binding pKi = 9.6 9.6 269 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
5311400 3291 None 1 Human Binding pKi = 9.6 9.6 2 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
900 3291 None 1 Human Binding pKi = 9.6 9.6 2 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL262197 3291 None 1 Human Binding pKi = 9.6 9.6 2 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
4627 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
864 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
9833444 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
CHEMBL1121 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
DB09142 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None None 10.1021/jm00126a007
4627 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
864 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
9833444 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
CHEMBL1121 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
DB09142 821 None 50 Human Binding pKi = 9.6 9.6 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None None 10.1016/S0960-894X(00)80678-2
16732163 142062 None 0 Human Binding pKi = 9.6 9.6 2 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL387948 142062 None 0 Human Binding pKi = 9.6 9.6 2 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 9 2 5 5.2 O=C(O)Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
44345980 114132 None 0 Human Binding pKi = 9.5 9.5 79 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 538 6 2 7 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL332902 114132 None 0 Human Binding pKi = 9.5 9.5 79 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 538 6 2 7 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
16732164 143301 None 0 Human Binding pKi = 9.5 9.5 2 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389711 143301 None 0 Human Binding pKi = 9.5 9.5 2 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ccn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10769001 113179 None 0 Human Binding pKi = 9.5 9.5 13803 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 549 5 3 4 5.7 Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331468 113179 None 0 Human Binding pKi = 9.5 9.5 13803 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 549 5 3 4 5.7 Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
4627 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
864 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
9833444 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL1121 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
DB09142 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None None 10.1021/jm0000416
4627 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
864 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
9833444 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
CHEMBL1121 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
DB09142 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None None 10.1021/jm00053a022
4627 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
864 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
9833444 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
CHEMBL1121 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
DB09142 821 None 50 Human Binding pKi = 9.5 9.5 -1 5
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL None None None None 10.1016/S0960-894X(00)80669-1
10505959 113489 None 0 Human Binding pKi = 9.5 9.5 74 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 513 6 2 4 5.4 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331975 113489 None 0 Human Binding pKi = 9.5 9.5 74 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 513 6 2 4 5.4 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL411271 212873 None 0 Rat Binding pKi = 9.5 9.5 -2 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
16733469 85516 None 0 Human Binding pKi = 9.5 9.5 4 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227333 85516 None 0 Human Binding pKi = 9.5 9.5 4 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 576 10 2 6 5.8 O=C(O)CSc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
10815832 15180 None 0 Human Binding pKi = 9.5 9.5 109 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 7 2 4 5.8 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL121021 15180 None 0 Human Binding pKi = 9.5 9.5 109 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 7 2 4 5.8 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
16733466 85515 None 0 Human Binding pKi = 9.5 9.5 3 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
CHEMBL227330 85515 None 0 Human Binding pKi = 9.5 9.5 3 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 558 10 2 5 5.6 O=C(O)CCc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C3CCCC3)C2=O)c1 10.1021/jm070139l
108187 925 None 37 Human Binding pKi = 9.5 9.5 -4 5
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
873 925 None 37 Human Binding pKi = 9.5 9.5 -4 5
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL2062154 925 None 37 Human Binding pKi = 9.5 9.5 -4 5
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL287735 925 None 37 Human Binding pKi = 9.5 9.5 -4 5
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
16733307 168820 None 0 Human Binding pKi = 9.4 9.4 1819 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 585 8 2 7 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(C(=O)O)co3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL437736 168820 None 0 Human Binding pKi = 9.4 9.4 1819 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 585 8 2 7 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(C(=O)O)co3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
4627 821 None 50 Human Binding pKi = 9.4 9.4 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
864 821 None 50 Human Binding pKi = 9.4 9.4 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
9833444 821 None 50 Human Binding pKi = 9.4 9.4 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
CHEMBL1121 821 None 50 Human Binding pKi = 9.4 9.4 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
DB09142 821 None 50 Human Binding pKi = 9.4 9.4 -1 5
Displacement of radiolabeled CCK-8s from human CCK2 receptorDisplacement of radiolabeled CCK-8s from human CCK2 receptor
ChEMBL None None None None 10.1021/jm8007618
9850043 112871 None 2 Human Binding pKi = 9.4 9.4 1 3
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 112871 None 2 Human Binding pKi = 9.4 9.4 1 3
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44328894 108622 None 0 Human Binding pKi = 9.4 9.4 25 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 587 5 2 4 4.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CC3CCC(CC3)C2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL320624 108622 None 0 Human Binding pKi = 9.4 9.4 25 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 587 5 2 4 4.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CC3CCC(CC3)C2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
108187 925 None 37 Human Binding pKi = 9.4 9.4 -4 5
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
873 925 None 37 Human Binding pKi = 9.4 9.4 -4 5
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL2062154 925 None 37 Human Binding pKi = 9.4 9.4 -4 5
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL287735 925 None 37 Human Binding pKi = 9.4 9.4 -4 5
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
44318341 205997 None 0 Human Binding pKi = 9.4 9.4 1 3
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL1628582 205997 None 0 Human Binding pKi = 9.4 9.4 1 3
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL84864 205997 None 0 Human Binding pKi = 9.4 9.4 1 3
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
4627 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
864 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
9833444 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
CHEMBL1121 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
DB09142 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL None None None None 10.1021/jm970477u
4627 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
864 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
9833444 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
CHEMBL1121 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
DB09142 821 None 50 Rat Binding pKi = 9.4 9.4 1 5
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
135529065 157013 None 0 Human Binding pKi = 9.4 9.4 7 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL407340 157013 None 0 Human Binding pKi = 9.4 9.4 7 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 7 2 7 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL1207511 208607 None 0 Human Binding pKi = 9.3 9.3 2398 2
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
CHEMBL412917 208607 None 0 Human Binding pKi = 9.3 9.3 2398 2
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(CS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80678-2
10768190 112829 None 0 Human Binding pKi = 9.3 9.3 15 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 516 6 2 4 6.0 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL330773 112829 None 0 Human Binding pKi = 9.3 9.3 15 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 516 6 2 4 6.0 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
44351446 156139 None 0 Human Binding pKi = 9.3 9.3 3 2
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 156139 None 0 Human Binding pKi = 9.3 9.3 3 2
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
6439414 3023 None 14 Mouse Binding pKi = 9.3 9.3 2454 2
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
867 3023 None 14 Mouse Binding pKi = 9.3 9.3 2454 2
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
CHEMBL3351022 3023 None 14 Mouse Binding pKi = 9.3 9.3 2454 2
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
CHEMBL341460 3023 None 14 Mouse Binding pKi = 9.3 9.3 2454 2
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 612 11 5 5 4.6 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)/C=C/C(=O)O 10.1021/jm00087a011
44318341 205997 None 0 Mouse Binding pKi = 9.3 9.3 -1 3
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL1628582 205997 None 0 Mouse Binding pKi = 9.3 9.3 -1 3
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL84864 205997 None 0 Mouse Binding pKi = 9.3 9.3 -1 3
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 698 10 5 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N)c(I)c1 10.1016/0960-894X(95)00435-V
10509035 14507 None 0 Human Binding pKi = 9.3 9.3 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
CHEMBL120150 14507 None 0 Human Binding pKi = 9.3 9.3 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 714 19 7 8 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CS(=O)(=O)O 10.1021/jm0000416
44271963 96723 None 0 Human Binding pKi = 9.3 9.3 4466 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL264273 96723 None 0 Human Binding pKi = 9.3 9.3 4466 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
10604664 155233 None 0 Human Binding pKi = 9.3 9.3 602 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 691 9 2 7 5.6 O=C(Nc1cccc(C(=O)OCCN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL402702 155233 None 0 Human Binding pKi = 9.3 9.3 602 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 691 9 2 7 5.6 O=C(Nc1cccc(C(=O)OCCN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10792765 113078 None 0 Human Binding pKi = 9.2 9.2 2754 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1cccc(O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL331244 113078 None 0 Human Binding pKi = 9.2 9.2 2754 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1cccc(O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
4627 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
864 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
9833444 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
CHEMBL1121 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
DB09142 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm9603072
CHEMBL132314 208700 None 0 Human Binding pKi = 9.2 9.2 2 4
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0303103
4627 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
864 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
9833444 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL1121 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
DB09142 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
10768579 113864 None 0 Human Binding pKi = 9.2 9.2 32 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 531 6 2 4 5.5 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL332568 113864 None 0 Human Binding pKi = 9.2 9.2 32 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 531 6 2 4 5.5 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
4627 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
864 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
9833444 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
CHEMBL1121 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
DB09142 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None None 10.1021/jm9603072
16732911 143214 None 0 Human Binding pKi = 9.2 9.2 4 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389639 143214 None 0 Human Binding pKi = 9.2 9.2 4 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 564 9 2 6 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10838957 12470 None 0 Human Binding pKi = 9.2 9.2 151 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 495 5 2 4 5.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL118622 12470 None 0 Human Binding pKi = 9.2 9.2 151 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 495 5 2 4 5.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(C#N)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
4627 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
864 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
9833444 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
CHEMBL1121 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
DB09142 821 None 50 Human Binding pKi = 9.2 9.2 -1 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL None None None None 10.1016/S0960-894X(00)80686-1
16732022 85509 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 601 8 2 7 6.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3csc(C(=O)O)n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227275 85509 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 601 8 2 7 6.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3csc(C(=O)O)n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10370321 12980 None 0 Human Binding pKi = 9.2 9.2 30902 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1ccc(O)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL118954 12980 None 0 Human Binding pKi = 9.2 9.2 30902 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 550 5 3 4 5.8 O=C(Nc1ccc(O)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10555899 113371 None 0 Human Binding pKi = 9.2 9.2 2344 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331763 113371 None 0 Human Binding pKi = 9.2 9.2 2344 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10552321 163908 None 0 Human Binding pKi = 9.2 9.2 165 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 5 2 3 5.3 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL420728 163908 None 0 Human Binding pKi = 9.2 9.2 165 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 5 2 3 5.3 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10792618 164351 None 0 Human Binding pKi = 9.2 9.2 70 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL421271 164351 None 0 Human Binding pKi = 9.2 9.2 70 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
4627 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
864 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
9833444 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
CHEMBL1121 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
DB09142 821 None 50 Rat Binding pKi = 9.2 9.2 1 5
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None None 10.1016/j.bmcl.2003.11.001
14802525 115475 None 1 Mouse Binding pKi = 9.2 9.2 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351024 115475 None 1 Mouse Binding pKi = 9.2 9.2 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 626 12 5 5 4.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
16732021 168474 None 0 Human Binding pKi = 9.2 9.2 549 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 9 2 8 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL435143 168474 None 0 Human Binding pKi = 9.2 9.2 549 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 588 9 2 8 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCc3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9850043 112871 None 2 Human Binding pKi = 9.2 9.2 1 3
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 112871 None 2 Human Binding pKi = 9.2 9.2 1 3
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10767708 14544 None 0 Human Binding pKi = 9.1 9.1 138 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 500 6 2 3 5.6 O=C(Nc1ccccc1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
CHEMBL120296 14544 None 0 Human Binding pKi = 9.1 9.1 138 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 500 6 2 3 5.6 O=C(Nc1ccccc1)NC1C(=O)N(CCC2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1021/jm990967h
10840039 113791 None 0 Human Binding pKi = 9.1 9.1 16 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 6 2 4 6.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL332403 113791 None 0 Human Binding pKi = 9.1 9.1 16 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 6 2 4 6.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
10723216 161993 None 0 Mouse Binding pKi = 9.1 9.1 4466 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 680 11 6 5 5.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL415936 161993 None 0 Mouse Binding pKi = 9.1 9.1 4466 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 680 11 6 5 5.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
5311400 3291 None 1 Rat Binding pKi = 9.1 9.1 -2 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
900 3291 None 1 Rat Binding pKi = 9.1 9.1 -2 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
CHEMBL262197 3291 None 1 Rat Binding pKi = 9.1 9.1 -2 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None None 10.1021/jm0000416
10554602 15291 None 0 Human Binding pKi = 9.1 9.1 29 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 546 7 2 4 6.3 CSc1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
CHEMBL121331 15291 None 0 Human Binding pKi = 9.1 9.1 29 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 546 7 2 4 6.3 CSc1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1 10.1021/jm990967h
16732165 168946 None 0 Human Binding pKi = 9.1 9.1 3235 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(ccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL438843 168946 None 0 Human Binding pKi = 9.1 9.1 3235 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(ccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732755 85448 None 0 Human Binding pKi = 9.1 9.1 10000 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.7 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226622 85448 None 0 Human Binding pKi = 9.1 9.1 10000 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.7 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL333477 211390 None 0 Human Binding pKi = 9.1 9.1 3 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm0000416
CHEMBL2372784 210288 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL333477 211390 None 0 Human Binding pKi = 9.1 9.1 3 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm9603072
16732444 143304 None 0 Human Binding pKi = 9.1 9.1 2570 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3cnn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389713 143304 None 0 Human Binding pKi = 9.1 9.1 2570 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3cnn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10722460 15190 None 0 Human Binding pKi = 9.1 9.1 309 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL121028 15190 None 0 Human Binding pKi = 9.1 9.1 309 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44461961 105607 None 0 Mouse Binding pKi = 9.1 9.1 9 3
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL2079605 105607 None 0 Mouse Binding pKi = 9.1 9.1 9 3
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
CHEMBL312252 105607 None 0 Mouse Binding pKi = 9.1 9.1 9 3
Binding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assayBinding affinity towards CCK-B receptor in mouse cerebral cortex membrane using [125I]bolton assay
ChEMBL 724 11 4 5 6.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccc(N=[N+]=[N-])c(I)c1 10.1016/0960-894X(95)00435-V
44451581 95823 None 0 Human Binding pKi = 9.1 9.1 5 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258863 95823 None 0 Human Binding pKi = 9.1 9.1 5 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(SCC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
16733310 168842 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 597 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL437930 168842 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 597 9 2 6 6.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9850043 112871 None 2 Human Binding pKi = 9.0 9.0 1 3
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 112871 None 2 Human Binding pKi = 9.0 9.0 1 3
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
3503 1891 None 16 Human Binding pKi = 9.0 9.0 1174 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 10.1016/S0960-894X(96)00544-6
5311147 1891 None 16 Human Binding pKi = 9.0 9.0 1174 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 10.1016/S0960-894X(96)00544-6
CHEMBL329305 1891 None 16 Human Binding pKi = 9.0 9.0 1174 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(N[C@H]1C(=O)N(c2ccccc2)c2c(N(C1=O)CC13CC4CC(C3)CC(C1)C4)cccc2)Nc1ccccc1 10.1016/S0960-894X(96)00544-6
10696354 113488 None 0 Human Binding pKi = 9.0 9.0 74 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 488 5 2 3 5.5 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL331971 113488 None 0 Human Binding pKi = 9.0 9.0 74 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 488 5 2 3 5.5 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
44346296 114495 None 0 Human Binding pKi = 9.0 9.0 1174 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 562 6 2 4 5.9 O=Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL333517 114495 None 0 Human Binding pKi = 9.0 9.0 1174 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 562 6 2 4 5.9 O=Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10698427 14552 None 0 Human Binding pKi = 9.0 9.0 645 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 578 6 3 4 5.8 O=C(Nc1cccc(C(=O)O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL120363 14552 None 0 Human Binding pKi = 9.0 9.0 645 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 578 6 3 4 5.8 O=C(Nc1cccc(C(=O)O)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
108187 925 None 37 Human Binding pKi = 9.0 9.0 -4 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
873 925 None 37 Human Binding pKi = 9.0 9.0 -4 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
CHEMBL2062154 925 None 37 Human Binding pKi = 9.0 9.0 -4 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
CHEMBL287735 925 None 37 Human Binding pKi = 9.0 9.0 -4 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1016/S0960-894X(00)80686-1
11527738 75987 None 0 Human Binding pKi = 9 9.0 -2 4
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL205455 75987 None 0 Human Binding pKi = 9 9.0 -2 4
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
44572200 179341 None 0 Human Binding pKi = 9 9.0 14 2
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL473612 179341 None 0 Human Binding pKi = 9 9.0 14 2
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL475226 179341 None 0 Human Binding pKi = 9 9.0 14 2
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
16732019 85432 None 0 Human Binding pKi = 9 9.0 3 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226533 85432 None 0 Human Binding pKi = 9 9.0 3 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 542 7 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nn[nH]n3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16731872 85447 None 0 Human Binding pKi = 9 9.0 1 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL226620 85447 None 0 Human Binding pKi = 9 9.0 1 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 530 8 2 5 5.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL2372780 210285 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC)C(=O)N[C@@H](Cc1ccc(S(=O)(=O)O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)O 10.1021/jm00053a022
9939572 37489 None 0 Mouse Binding pKi = 9 9.0 21 3
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL14557 37489 None 0 Mouse Binding pKi = 9 9.0 21 3
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067949 37489 None 0 Mouse Binding pKi = 9 9.0 21 3
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44346345 113082 None 0 Human Binding pKi = 9.0 9.0 43 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 523 5 2 4 5.1 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3CC4CCC3C4)C2=O)c1 10.1021/jm990967h
CHEMBL331262 113082 None 0 Human Binding pKi = 9.0 9.0 43 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 523 5 2 4 5.1 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3CC4CCC3C4)C2=O)c1 10.1021/jm990967h
16732017 85465 None 0 Human Binding pKi = 9.0 9.0 6025 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 9 2 6 5.0 CN(CC(=O)O)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm070139l
CHEMBL226726 85465 None 0 Human Binding pKi = 9.0 9.0 6025 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 9 2 6 5.0 CN(CC(=O)O)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm070139l
9939572 37489 None 0 Mouse Binding pKi = 9.0 9.0 21 3
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL14557 37489 None 0 Mouse Binding pKi = 9.0 9.0 21 3
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL2067949 37489 None 0 Mouse Binding pKi = 9.0 9.0 21 3
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL218327 209392 None 0 Human Binding pKi = 9.0 9.0 -2 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
9939572 37489 None 0 Mouse Binding pKi = 9.0 9.0 21 3
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm000960w
CHEMBL14557 37489 None 0 Mouse Binding pKi = 9.0 9.0 21 3
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm000960w
CHEMBL2067949 37489 None 0 Mouse Binding pKi = 9.0 9.0 21 3
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm000960w
10579091 14370 None 0 Human Binding pKi = 9.0 9.0 398 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.2 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL120021 14370 None 0 Human Binding pKi = 9.0 9.0 398 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.2 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10552320 117457 None 0 Human Binding pKi = 9.0 9.0 109 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.2 CC(C)C(C)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL339879 117457 None 0 Human Binding pKi = 9.0 9.0 109 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.2 CC(C)C(C)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10415968 115465 None 0 Mouse Binding pKi = 8.9 8.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351013 115465 None 0 Mouse Binding pKi = 8.9 8.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 588 12 5 5 4.3 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)/C=C/C(=O)O)Cc1ccccc1 10.1021/jm00087a011
118727697 117588 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2115 63 21 28 0.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc(CN(Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
CHEMBL3400295 117588 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2115 63 21 28 0.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn1cc(CN(Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)Cc2cn(CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)nn2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
136036823 155676 None 0 Human Binding pKi = 8.9 8.9 37 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL404967 155676 None 0 Human Binding pKi = 8.9 8.9 37 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 574 7 2 7 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
44425006 142078 None 0 Human Binding pKi = 8.9 8.9 3311 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.6 CC1CCCC1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL388068 142078 None 0 Human Binding pKi = 8.9 8.9 3311 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 544 8 2 5 5.6 CC1CCCC1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9853208 101722 None 0 Mouse Binding pKi = 8.9 8.9 1071 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 710 11 6 9 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2[nH]ccc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
CHEMBL299540 101722 None 0 Mouse Binding pKi = 8.9 8.9 1071 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 710 11 6 9 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2[nH]ccc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
10652142 101568 None 0 Mouse Binding pKi = 8.9 8.9 1819 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 5 6 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccsc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL298521 101568 None 0 Mouse Binding pKi = 8.9 8.9 1819 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 5 6 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccsc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
10555899 113371 None 0 Human Binding pKi = 8.9 8.9 2344 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331763 113371 None 0 Human Binding pKi = 8.9 8.9 2344 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 623 8 5 6 5.2 CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
11801315 114772 None 0 Human Binding pKi = 8.9 8.9 50 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.0 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL333930 114772 None 0 Human Binding pKi = 8.9 8.9 50 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 577 6 2 4 6.0 CN(C)c1cccc(NC(=O)NC2C(=O)N(CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
44357046 28057 None 2 Rat Binding pKi = 8.9 8.9 -18 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL137280 28057 None 2 Rat Binding pKi = 8.9 8.9 -18 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL206974 209180 None 0 Human Binding pKi = 8.9 8.9 1 5
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
CHEMBL336381 211581 None 0 Human Binding pKi = 8.9 8.9 97 5
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
10769748 113005 None 0 Human Binding pKi = 8.9 8.9 1148 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 6 3 4 6.1 CC(=O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL331119 113005 None 0 Human Binding pKi = 8.9 8.9 1148 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 6 3 4 6.1 CC(=O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
10604418 12454 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 662 18 6 6 2.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C 10.1021/jm0000416
CHEMBL118610 12454 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 662 18 6 6 2.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C 10.1021/jm0000416
10098459 4264 None 0 Human Binding pKi = 8.9 8.9 208 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 528 7 2 3 5.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100548 4264 None 0 Human Binding pKi = 8.9 8.9 208 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 528 7 2 3 5.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
10508004 11797 None 0 Human Binding pKi = 8.9 8.9 2454 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1ccc(Br)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL118189 11797 None 0 Human Binding pKi = 8.9 8.9 2454 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1ccc(Br)cc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
108187 925 None 37 Mouse Binding pKi = 8.8 8.8 -9 5
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
873 925 None 37 Mouse Binding pKi = 8.8 8.8 -9 5
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
CHEMBL2062154 925 None 37 Mouse Binding pKi = 8.8 8.8 -9 5
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
CHEMBL287735 925 None 37 Mouse Binding pKi = 8.8 8.8 -9 5
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm00087a011
CHEMBL206974 209180 None 0 Human Binding pKi = 8.8 8.8 1 5
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44346255 116879 None 0 Human Binding pKi = 8.8 8.8 30 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 2 7 6.7 CC(C)(C1CCCC1)N1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL338278 116879 None 0 Human Binding pKi = 8.8 8.8 30 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 564 6 2 7 6.7 CC(C)(C1CCCC1)N1C(=O)C(NC(=O)Nc2cccc(C3N=NN=N3)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10004216 4741 None 0 Human Binding pKi = 8.8 8.8 11 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL103750 4741 None 0 Human Binding pKi = 8.8 8.8 11 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10792724 14408 None 0 Human Binding pKi = 8.8 8.8 162 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 5 2 3 6.4 Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL120031 14408 None 0 Human Binding pKi = 8.8 8.8 162 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 5 2 3 6.4 Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
19043400 98740 None 0 Human Binding pKi = 8.8 8.8 162 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 480 4 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
CHEMBL278018 98740 None 0 Human Binding pKi = 8.8 8.8 162 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 480 4 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
10795162 119036 None 0 Mouse Binding pKi = 8.8 8.8 630 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL2067970 119036 None 0 Mouse Binding pKi = 8.8 8.8 630 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342616 119036 None 0 Mouse Binding pKi = 8.8 8.8 630 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
16733185 142090 None 0 Human Binding pKi = 8.8 8.8 346 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 8 2 5 6.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccc(C(=O)O)c3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL388143 142090 None 0 Human Binding pKi = 8.8 8.8 346 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 594 8 2 5 6.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cccc(C(=O)O)c3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44296914 101247 None 0 Mouse Binding pKi = 8.8 8.8 1318 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 765 12 5 5 7.0 O=C(CC1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL296167 101247 None 0 Mouse Binding pKi = 8.8 8.8 1318 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 765 12 5 5 7.0 O=C(CC1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm9508907
5311201 207393 None 35 Human Binding pKi = 8.8 8.8 -27 6
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
CHEMBL9387 207393 None 35 Human Binding pKi = 8.8 8.8 -27 6
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
10795162 119036 None 0 Mouse Binding pKi = 8.8 8.8 630 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067970 119036 None 0 Mouse Binding pKi = 8.8 8.8 630 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL342616 119036 None 0 Mouse Binding pKi = 8.8 8.8 630 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44329156 207632 None 0 Human Binding pKi = 8.8 8.8 50 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 535 5 2 4 4.0 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL95200 207632 None 0 Human Binding pKi = 8.8 8.8 50 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 535 5 2 4 4.0 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL430298 213616 None 0 Human Binding pKi = 8.8 8.8 -3 4
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
CHEMBL382349 212300 None 0 Human Binding pKi = 8.8 8.8 1 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44379188 57482 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 614 11 4 7 4.5 C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80669-1
CHEMBL165869 57482 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 614 11 4 7 4.5 C[C@@](N)(Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1016/S0960-894X(00)80669-1
44346126 15264 None 0 Human Binding pKi = 8.8 8.8 27 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 514 4 2 3 5.7 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
CHEMBL121267 15264 None 0 Human Binding pKi = 8.8 8.8 27 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 514 4 2 3 5.7 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2CC3CCC2C3)C1=O 10.1021/jm990967h
5311201 207393 None 35 Human Binding pKi = 8.7 8.7 -27 6
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80686-1
CHEMBL9387 207393 None 35 Human Binding pKi = 8.7 8.7 -27 6
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/S0960-894X(00)80686-1
10723875 14940 None 0 Human Binding pKi = 8.7 8.7 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
CHEMBL120827 14940 None 0 Human Binding pKi = 8.7 8.7 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 767 21 7 7 2.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)NCc1ccccc1 10.1021/jm0000416
16731874 85456 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226675 85456 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 546 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
9958214 114791 None 0 Human Binding pKi = 8.7 8.7 269 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL333979 114791 None 0 Human Binding pKi = 8.7 8.7 269 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 517 7 2 4 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
108187 925 None 37 Human Binding pKi = 8.7 8.7 -4 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
873 925 None 37 Human Binding pKi = 8.7 8.7 -4 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL2062154 925 None 37 Human Binding pKi = 8.7 8.7 -4 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL287735 925 None 37 Human Binding pKi = 8.7 8.7 -4 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
44351445 116932 None 0 Human Binding pKi = 8.7 8.7 1 2
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 116932 None 0 Human Binding pKi = 8.7 8.7 1 2
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
10793342 113103 None 0 Human Binding pKi = 8.7 8.7 158 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 579 6 2 5 6.0 O=C(Nc1cccc([N+](=O)[O-])c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL331405 113103 None 0 Human Binding pKi = 8.7 8.7 158 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 579 6 2 5 6.0 O=C(Nc1cccc([N+](=O)[O-])c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
16732020 85508 None 0 Human Binding pKi = 8.7 8.7 2 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
CHEMBL227254 85508 None 0 Human Binding pKi = 8.7 8.7 2 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 8 4.7 CN(c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1)c1nn[nH]n1 10.1021/jm070139l
10768658 114800 None 0 Human Binding pKi = 8.7 8.7 42 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.0 O=C(Nc1ccccc1)NC1C(=O)N(CC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL334020 114800 None 0 Human Binding pKi = 8.7 8.7 42 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.0 O=C(Nc1ccccc1)NC1C(=O)N(CC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
9960432 39422 None 5 Human Binding pKi = 8 8.0 12 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL147186 39422 None 5 Human Binding pKi = 8 8.0 12 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 605 8 3 5 5.0 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
45486935 196757 None 0 Human Binding pKi = 8 8.0 25 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 612 8 3 7 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL565298 196757 None 0 Human Binding pKi = 8 8.0 25 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 612 8 3 7 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
45102806 196761 None 0 Human Binding pKi = 8 8.0 15 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 646 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL565324 196761 None 0 Human Binding pKi = 8 8.0 15 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 646 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
45486964 197392 None 0 Human Binding pKi = 8 8.0 39 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 606 8 3 6 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL569391 197392 None 0 Human Binding pKi = 8 8.0 39 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 606 8 3 6 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
45487006 198910 None 0 Human Binding pKi = 8 8.0 10 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 666 8 3 6 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL584525 198910 None 0 Human Binding pKi = 8 8.0 10 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 666 8 3 6 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
11786290 80546 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1cc(Br)c(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL214836 80546 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1cc(Br)c(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
10004216 4741 None 0 Human Binding pKi = 8 8.0 11 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL103750 4741 None 0 Human Binding pKi = 8 8.0 11 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL120632 208603 None 33 Human Binding pKi = 8.0 8.0 5 3
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
10747599 25858 None 0 Mouse Binding pKi = 8.0 8.0 46 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2cccc3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL135350 25858 None 0 Mouse Binding pKi = 8.0 8.0 46 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2cccc3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
44331506 107283 None 0 Human Binding pKi = 8.0 8.0 22 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 574 5 2 3 6.8 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL317108 107283 None 0 Human Binding pKi = 8.0 8.0 22 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 574 5 2 3 6.8 O=C(Nc1cccc(Cl)c1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL1172249 208580 None 0 Human Binding pKi = 7 7.0 -16 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
16090780 80330 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c2nsnc12 10.1021/jm060590x
CHEMBL214235 80330 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c2nsnc12 10.1021/jm060590x
16090684 82280 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc2nsnc2c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1021/jm060590x
CHEMBL217170 82280 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 494 4 1 6 4.2 Cc1ccc2nsnc2c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1021/jm060590x
44417429 141390 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 5 2 7 3.5 O=C(c1ccc(CS)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL383919 141390 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 5 2 7 3.5 O=C(c1ccc(CS)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
45486970 197627 None 0 Human Binding pKi = 6 6.0 3 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 578 8 3 7 5.0 CC(C)(c1ccc(Cl)cc1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
CHEMBL570761 197627 None 0 Human Binding pKi = 6 6.0 3 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 578 8 3 7 5.0 CC(C)(c1ccc(Cl)cc1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
45486995 197799 None 0 Human Binding pKi = 6 6.0 1 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 8 2 6 4.5 O=C(NCCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL572046 197799 None 0 Human Binding pKi = 6 6.0 1 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 8 2 6 4.5 O=C(NCCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
53465843 69408 None 0 Human Binding pKi = 6 6.0 -1 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL1933103 69408 None 0 Human Binding pKi = 6 6.0 -1 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
53465844 69409 None 0 Human Binding pKi = 6 6.0 -131 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL1933104 69409 None 0 Human Binding pKi = 6 6.0 -131 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)N[C@H](CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
11248998 159460 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 6 1 4 4.4 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL410138 159460 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 6 1 4 4.4 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1 10.1016/j.bmc.2007.12.047
16090795 141422 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 484 4 1 6 4.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCc2ccccc2C1 10.1021/jm060590x
CHEMBL384109 141422 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 484 4 1 6 4.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCc2ccccc2C1 10.1021/jm060590x
11362153 141701 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL385636 141701 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11430523 160331 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1c(Cl)cccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL411069 160331 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1c(Cl)cccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11555110 11964 None 0 Mouse Binding pKi = 6 6.0 5 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 500 7 5 4 5.7 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1182962 11964 None 0 Mouse Binding pKi = 6 6.0 5 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 500 7 5 4 5.7 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067954 11964 None 0 Mouse Binding pKi = 6 6.0 5 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 500 7 5 4 5.7 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4[nH]ccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
11554414 12278 None 0 Mouse Binding pKi = 6 6.0 7 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 461 7 4 4 5.2 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184820 12278 None 0 Mouse Binding pKi = 6 6.0 7 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 461 7 4 4 5.2 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067965 12278 None 0 Mouse Binding pKi = 6 6.0 7 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 461 7 4 4 5.2 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
44346947 15295 None 0 Mouse Binding pKi = 5 5.0 -1 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 389 4 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1CCCCC1 10.1021/jm00048a001
CHEMBL121342 15295 None 0 Mouse Binding pKi = 5 5.0 -1 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 389 4 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1CCCCC1 10.1021/jm00048a001
CHEMBL2112488 209237 None 0 Human Binding pKi = 4 4.0 - 1
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
11758573 110340 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 619 7 2 5 4.9 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL324032 110340 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 619 7 2 5 4.9 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10532660 113276 None 0 Human Binding pKi = 5.0 5.0 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
CHEMBL331495 113276 None 0 Human Binding pKi = 5.0 5.0 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
10676550 119360 None 0 Mouse Binding pKi = 7.0 7.0 12 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm00021a019
CHEMBL344396 119360 None 0 Mouse Binding pKi = 7.0 7.0 12 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm00021a019
71452773 79585 None 0 Rat Binding pKi = 6.0 6.0 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL2114379 79585 None 0 Rat Binding pKi = 6.0 6.0 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44357011 116568 None 0 Mouse Binding pKi = 5.0 5.0 -1 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 779 11 3 7 6.8 COC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)OC)c1 10.1021/jm00021a019
CHEMBL336453 116568 None 0 Mouse Binding pKi = 5.0 5.0 -1 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 779 11 3 7 6.8 COC(=O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)OC)c1 10.1021/jm00021a019
1647 1312 None 45 Human Binding pKi = 8.0 8.0 -11 9
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
5462471 1312 None 45 Human Binding pKi = 8.0 8.0 -11 9
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
CHEMBL113995 1312 None 45 Human Binding pKi = 8.0 8.0 -11 9
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
CHEMBL38874 1312 None 45 Human Binding pKi = 8.0 8.0 -11 9
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL None None None None 10.1021/jm800174p
CHEMBL353862 211726 None 0 Rat Binding pKi = 8.0 8.0 -1 3
Tested for the inhibition of [3H]pCCK-8 binding to Merk CCK-B antagonist L365,260 receptor in rat brain membranesTested for the inhibition of [3H]pCCK-8 binding to Merk CCK-B antagonist L365,260 receptor in rat brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)c1ccccc1 10.1016/S0960-894X(00)80678-2
10768308 14893 None 0 Human Binding pKi = 7.9 7.9 19 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 4 2 3 5.7 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
CHEMBL120793 14893 None 0 Human Binding pKi = 7.9 7.9 19 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 520 4 2 3 5.7 O=C(Nc1ccccc1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
11571140 71699 None 0 Mouse Binding pKi = 7.9 7.9 -2 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196517 71699 None 0 Mouse Binding pKi = 7.9 7.9 -2 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.9 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL120528 208601 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm0000416
CHEMBL1172253 208583 None 0 Human Binding pKi = 7.0 7.0 -851 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL408083 212696 None 0 Human Binding pKi = 6.0 6.0 -3 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
16100406 83222 None 0 Human Binding pKi = 6.0 6.0 -281 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL218600 83222 None 0 Human Binding pKi = 6.0 6.0 -281 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
11512219 140635 None 0 Mouse Binding pKi = 5.0 5.0 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 3 6.8 CNc1cccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL381452 140635 None 0 Mouse Binding pKi = 5.0 5.0 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 3 6.8 CNc1cccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL3350665 211480 None 0 Human Binding pKi = 7.0 7.0 3 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
10459641 112236 None 0 Human Binding pKi = 6.9 6.9 26 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 529 9 3 4 5.4 COc1ccc(CCNC(=O)C(C)(Cc2c[nH]c3ccccc23)NC(=O)OC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)cc1 10.1021/jm00072a005
CHEMBL329088 112236 None 0 Human Binding pKi = 6.9 6.9 26 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 529 9 3 4 5.4 COc1ccc(CCNC(=O)C(C)(Cc2c[nH]c3ccccc23)NC(=O)OC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)cc1 10.1021/jm00072a005
44344934 14416 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 615 8 2 6 4.2 COc1ccc2c(c1)C(=O)CC(C(=O)NCC(=O)O)N(C(C)=O)C(CC13CC4CC(CC(C4)C1)C3)C(=O)N2Cc1ccccc1 10.1021/jm000960w
CHEMBL120043 14416 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 615 8 2 6 4.2 COc1ccc2c(c1)C(=O)CC(C(=O)NCC(=O)O)N(C(C)=O)C(CC13CC4CC(CC(C4)C1)C3)C(=O)N2Cc1ccccc1 10.1021/jm000960w
5311201 207393 None 35 Rat Binding pKi = 7.9 7.9 -234 6
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
CHEMBL9387 207393 None 35 Rat Binding pKi = 7.9 7.9 -234 6
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
11527738 75987 None 0 Dog Binding pKi = 7.9 7.9 -12 4
Binding affinity to canine CCK2 receptorBinding affinity to canine CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205455 75987 None 0 Dog Binding pKi = 7.9 7.9 -12 4
Binding affinity to canine CCK2 receptorBinding affinity to canine CCK2 receptor
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
9985866 115476 None 0 Mouse Binding pKi = 7.9 7.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 590 13 5 5 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351025 115476 None 0 Mouse Binding pKi = 7.9 7.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 590 13 5 5 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
44357058 164856 None 0 Mouse Binding pKi = 7.9 7.9 173 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 785 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL421921 164856 None 0 Mouse Binding pKi = 7.9 7.9 173 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 785 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44329798 107547 None 0 Human Binding pKi = 7.9 7.9 1 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL318852 107547 None 0 Human Binding pKi = 7.9 7.9 1 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
10370499 36950 None 0 Mouse Binding pKi = 7.9 7.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL145133 36950 None 0 Mouse Binding pKi = 7.9 7.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
45487002 197587 None 0 Human Binding pKi = 7.9 7.9 10 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 672 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL570520 197587 None 0 Human Binding pKi = 7.9 7.9 10 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 672 8 3 7 5.1 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
11802624 102034 None 0 Mouse Binding pKi = 7.9 7.9 64 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067966 102034 None 0 Mouse Binding pKi = 7.9 7.9 64 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL301810 102034 None 0 Mouse Binding pKi = 7.9 7.9 64 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44328951 164595 None 0 Human Binding pKi = 7.9 7.9 3 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 533 5 2 4 3.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL421575 164595 None 0 Human Binding pKi = 7.9 7.9 3 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 533 5 2 4 3.8 O=C(Nc1ccc(F)cc1)NC1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2F)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL1172252 208582 None 0 Human Binding pKi = 6.9 6.9 -173 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
11542079 71720 None 0 Mouse Binding pKi = 6.9 6.9 -2 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196580 71720 None 0 Mouse Binding pKi = 6.9 6.9 -2 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 483 7 3 3 6.5 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
44344933 168439 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.5 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(C)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL434988 168439 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.5 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(C)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
16731712 85437 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 434 5 2 4 4.2 CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226570 85437 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 434 5 2 4 4.2 CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44351414 116874 None 0 Human Binding pKi = 6.9 6.9 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1CC(=O)O 10.1021/jm970439a
CHEMBL338252 116874 None 0 Human Binding pKi = 6.9 6.9 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1CC(=O)O 10.1021/jm970439a
90663557 106695 None 0 Rat Binding pKi = 6.9 6.9 -6165 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1152 31 11 13 2.0 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3143672 106695 None 0 Rat Binding pKi = 6.9 6.9 -6165 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1152 31 11 13 2.0 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
118719252 115468 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 501 8 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)O[C@H]1CC2CCC1(C)C2(C)C)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL3351016 115468 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 501 8 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)O[C@H]1CC2CCC1(C)C2(C)C)C(=O)NCCc1ccccc1 10.1021/jm00087a011
11362975 81554 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 452 4 1 6 4.3 O=C(c1cc2ccccc2cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL216134 81554 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 452 4 1 6 4.3 O=C(c1cc2ccccc2cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
16090651 141948 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 482 4 1 7 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL387194 141948 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 482 4 1 7 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
11178846 168963 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 468 5 1 7 4.4 O=C(c1ccc(-c2ccco2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL438984 168963 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 468 5 1 7 4.4 O=C(c1ccc(-c2ccco2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
9870515 12259 None 0 Mouse Binding pKi = 6.9 6.9 63 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 498 7 4 3 6.1 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184696 12259 None 0 Mouse Binding pKi = 6.9 6.9 63 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 498 7 4 3 6.1 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067955 12259 None 0 Mouse Binding pKi = 6.9 6.9 63 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 498 7 4 3 6.1 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
46235271 73646 None 2 Human Binding pKi = 5.9 5.9 -2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pKi = 5.9 5.9 -2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
45486971 197350 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 660 9 3 7 6.5 O=C(N[C@H](C(=O)O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569018 197350 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 660 9 3 7 6.5 O=C(N[C@H](C(=O)O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
45486974 197688 None 0 Human Binding pKi = 5.9 5.9 -50 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 580 7 3 7 4.8 C[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)[C@@H](O)c1cccc(Br)c1 10.1016/j.bmcl.2009.09.064
CHEMBL571206 197688 None 0 Human Binding pKi = 5.9 5.9 -50 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 580 7 3 7 4.8 C[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)[C@@H](O)c1cccc(Br)c1 10.1016/j.bmcl.2009.09.064
44417439 81653 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 509 7 2 7 3.4 O=C(C1=C(NS(=O)(=O)c2cccc3nsnc23)CC(NCc2ccccc2)C=C1)N1CCCCC1 10.1021/jm060590x
CHEMBL216360 81653 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 509 7 2 7 3.4 O=C(C1=C(NS(=O)(=O)c2cccc3nsnc23)CC(NCc2ccccc2)C=C1)N1CCCCC1 10.1021/jm060590x
16090796 141478 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 464 4 1 6 4.3 CC1CC(C)CN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)C1 10.1021/jm060590x
CHEMBL384387 141478 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 464 4 1 6 4.3 CC1CC(C)CN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)C1 10.1021/jm060590x
11431264 141715 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 2 7 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(CO)CC1 10.1021/jm060590x
CHEMBL385734 141715 None 0 Human Binding pKi = 5.9 5.9 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 2 7 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(CO)CC1 10.1021/jm060590x
9890720 168468 None 0 Mouse Binding pKi = 5.9 5.9 2 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL2067971 168468 None 0 Mouse Binding pKi = 5.9 5.9 2 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL435127 168468 None 0 Mouse Binding pKi = 5.9 5.9 2 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm049069y
10580492 14534 None 0 Human Binding pKi = 5.9 5.9 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
CHEMBL120257 14534 None 0 Human Binding pKi = 5.9 5.9 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
10628696 23346 None 0 Mouse Binding pKi = 5.9 5.9 - 1
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 723 11 5 5 6.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm00021a019
CHEMBL133249 23346 None 0 Mouse Binding pKi = 5.9 5.9 - 1
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 723 11 5 5 6.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm00021a019
44356430 115229 None 0 Mouse Binding pKi = 7.9 7.9 70 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL334714 115229 None 0 Mouse Binding pKi = 7.9 7.9 70 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
11712880 138921 None 0 Human Binding pKi = 7.9 7.9 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL378388 138921 None 0 Human Binding pKi = 7.9 7.9 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 6 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11555166 139828 None 0 Human Binding pKi = 7.9 7.9 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL379902 139828 None 0 Human Binding pKi = 7.9 7.9 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
10817243 113515 None 0 Human Binding pKi = 7.9 7.9 22 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 7 2 4 6.6 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL332128 113515 None 0 Human Binding pKi = 7.9 7.9 22 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 591 7 2 4 6.6 CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
11802624 102034 None 0 Mouse Binding pKi = 7.9 7.9 64 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL2067966 102034 None 0 Mouse Binding pKi = 7.9 7.9 64 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL301810 102034 None 0 Mouse Binding pKi = 7.9 7.9 64 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 673 11 5 5 6.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
9832467 144291 None 0 Mouse Binding pKi = 7.9 7.9 -15 5
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL390519 144291 None 0 Mouse Binding pKi = 7.9 7.9 -15 5
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
10580234 99032 None 0 Mouse Binding pKi = 7.9 7.9 251 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]ccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL280248 99032 None 0 Mouse Binding pKi = 7.9 7.9 251 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]ccc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
10257865 208436 None 4 Mouse Binding pKi = 7.9 7.9 -2 5
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 208436 None 4 Mouse Binding pKi = 7.9 7.9 -2 5
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
11613212 72099 None 0 Mouse Binding pKi = 7.9 7.9 -1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL197780 72099 None 0 Mouse Binding pKi = 7.9 7.9 -1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 7 3 4 6.4 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(COC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
44408525 169426 None 0 Human Binding pKi = 5.9 5.9 -56 3
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL442483 169426 None 0 Human Binding pKi = 5.9 5.9 -56 3
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1075 30 12 14 1.5 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O 10.1021/jm050851n
10430432 18823 None 0 Human Binding pKi = 4.9 4.9 -25703 5
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 389 5 1 4 4.2 CN1c2ccccc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
CHEMBL127969 18823 None 0 Human Binding pKi = 4.9 4.9 -25703 5
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 389 5 1 4 4.2 CN1c2ccccc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
9890720 168468 None 0 Mouse Binding pKi = 5.9 5.9 2 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL2067971 168468 None 0 Mouse Binding pKi = 5.9 5.9 2 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL435127 168468 None 0 Mouse Binding pKi = 5.9 5.9 2 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 466 6 3 2 7.3 O=C(O)c1cccc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)c1 10.1021/jm0490686
10099504 208211 None 0 Human Binding pKi = 6.9 6.9 14 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 568 10 2 4 5.8 CC(Cc1cccc2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL98516 208211 None 0 Human Binding pKi = 6.9 6.9 14 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 568 10 2 4 5.8 CC(Cc1cccc2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
101629632 115464 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 461 8 3 3 5.1 C[C@@H]1CCCC[C@H]1OC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL3351012 115464 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 461 8 3 3 5.1 C[C@@H]1CCCC[C@H]1OC(=O)NC(C)(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1 10.1021/jm00087a011
10794888 165250 None 0 Mouse Binding pKi = 6.9 6.9 15 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1 10.1021/jm00021a019
CHEMBL422981 165250 None 0 Mouse Binding pKi = 6.9 6.9 15 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1 10.1021/jm00021a019
118719250 115466 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3351014 115466 None 0 Mouse Binding pKi = 6.9 6.9 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
10531553 116628 None 0 Mouse Binding pKi = 6.9 6.9 31 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
CHEMBL336896 116628 None 0 Mouse Binding pKi = 6.9 6.9 31 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
10077166 99932 None 0 Rat Binding pKi = 7.9 7.9 75 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL286247 99932 None 0 Rat Binding pKi = 7.9 7.9 75 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 591 10 3 4 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1016/s0960-894x(98)00231-5
44280157 155727 None 0 Rat Binding pKi = 7.9 7.9 75 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL405468 155727 None 0 Rat Binding pKi = 7.9 7.9 75 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351477 116845 None 0 Human Binding pKi = 7.9 7.9 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 569 7 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338072 116845 None 0 Human Binding pKi = 7.9 7.9 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 569 7 3 4 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351469 116933 None 0 Rat Binding pKi = 7.9 7.9 -2 2
Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338526 116933 None 0 Rat Binding pKi = 7.9 7.9 -2 2
Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compounds were tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
5311201 207393 None 35 Human Binding pKi = 7.9 7.9 -27 6
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL9387 207393 None 35 Human Binding pKi = 7.9 7.9 -27 6
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL3351055 211537 None 0 Human Binding pKi = 7.9 7.9 70 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)c1ccccc1 10.1021/jm00053a022
44329798 107547 None 0 Mouse Binding pKi = 7.9 7.9 -1 5
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL318852 107547 None 0 Mouse Binding pKi = 7.9 7.9 -1 5
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand (icv)
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
10482868 107402 None 0 Human Binding pKi = 7.9 7.9 2 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL317999 107402 None 0 Human Binding pKi = 7.9 7.9 2 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL353862 211726 None 0 Human Binding pKi = 7.9 7.9 1 3
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)c1ccccc1 10.1016/S0960-894X(00)80678-2
44580901 169465 None 0 Human Binding pKi = 7.9 7.9 -3 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL442943 169465 None 0 Human Binding pKi = 7.9 7.9 -3 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
9853654 22787 None 41 Human Binding pKi = 7.8 7.8 31 2
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
CHEMBL1328 22787 None 41 Human Binding pKi = 7.8 7.8 31 2
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
CHEMBL3351052 211534 None 0 Human Binding pKi = 6.9 6.9 14 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C1CCCCC1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL2370437 209848 None 0 Human Binding pKi = 5.9 5.9 10 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
11571166 141312 None 0 Mouse Binding pKi = 6.9 6.9 -1 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL383386 141312 None 0 Mouse Binding pKi = 6.9 6.9 -1 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1cccc(C)c1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
46235271 73646 None 2 Human Binding pKi = 5.9 5.9 -2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pKi = 5.9 5.9 -2 2
Displacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
73354642 89456 None 0 Rat Binding pKi = 6.9 6.9 -2 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371225 89456 None 0 Rat Binding pKi = 6.9 6.9 -2 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
11583614 166125 None 0 Mouse Binding pKi = 5.8 5.8 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 6 3 3 6.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL426102 166125 None 0 Mouse Binding pKi = 5.8 5.8 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 6 3 3 6.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL431676 213625 None 0 Human Binding pKi = 5.8 5.8 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)O 10.1021/jm0000416
44387568 62205 None 0 Human Binding pKi = 7.8 7.8 1 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
CHEMBL177799 62205 None 0 Human Binding pKi = 7.8 7.8 1 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
5311201 207393 None 35 Rat Binding pKi = 7.8 7.8 -234 6
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
CHEMBL9387 207393 None 35 Rat Binding pKi = 7.8 7.8 -234 6
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1016/s0960-894x(98)00231-5
5311201 207393 None 35 Rat Binding pKi = 7.8 7.8 -234 6
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL9387 207393 None 35 Rat Binding pKi = 7.8 7.8 -234 6
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL208479 209197 None 0 Human Binding pKi = 7.8 7.8 -5 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
CHEMBL218763 209397 None 0 Human Binding pKi = 7.8 7.8 -15 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
73347063 89452 None 0 Human Binding pKi = 7.8 7.8 1 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371221 89452 None 0 Human Binding pKi = 7.8 7.8 1 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10327028 89453 None 0 Human Binding pKi = 7.8 7.8 1 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371222 89453 None 0 Human Binding pKi = 7.8 7.8 1 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10480793 115423 None 0 Mouse Binding pKi = 7.8 7.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3350395 115423 None 0 Mouse Binding pKi = 7.8 7.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
10747623 169479 None 0 Mouse Binding pKi = 7.8 7.8 29 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 746 12 6 5 6.1 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCCc2c[nH]c3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL443028 169479 None 0 Mouse Binding pKi = 7.8 7.8 29 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 746 12 6 5 6.1 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCCc2c[nH]c3ccccc23)cc(C(=O)O)c1 10.1021/jm00021a019
11656338 75943 None 0 Human Binding pKi = 7.8 7.8 1 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205198 75943 None 0 Human Binding pKi = 7.8 7.8 1 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CO)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
10603971 101613 None 0 Mouse Binding pKi = 7.8 7.8 208 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 624 11 6 5 5.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL298861 101613 None 0 Mouse Binding pKi = 7.8 7.8 208 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 624 11 6 5 5.2 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
11802426 100281 None 0 Rat Binding pKi = 7.8 7.8 50 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL289021 100281 None 0 Rat Binding pKi = 7.8 7.8 50 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 653 8 3 5 6.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351445 116932 None 0 Rat Binding pKi = 7.8 7.8 -1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 116932 None 0 Rat Binding pKi = 7.8 7.8 -1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
118719253 115471 None 0 Mouse Binding pKi = 7.8 7.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 531 9 4 4 5.1 CC1(C)C2CCC1(C)C(OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)N[C@H](CO)Cc1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351019 115471 None 0 Mouse Binding pKi = 7.8 7.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 531 9 4 4 5.1 CC1(C)C2CCC1(C)C(OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)N[C@H](CO)Cc1ccccc1)C2 10.1021/jm00087a011
45255234 199034 None 0 Human Binding pKi = 7.8 7.8 15 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL585914 199034 None 0 Human Binding pKi = 7.8 7.8 15 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
45255234 199034 None 0 Human Binding pKi = 7.8 7.8 15 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL585914 199034 None 0 Human Binding pKi = 7.8 7.8 15 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
11613982 140423 None 0 Human Binding pKi = 7.8 7.8 9 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380907 140423 None 0 Human Binding pKi = 7.8 7.8 9 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 543 7 1 5 6.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
16090790 141613 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.4 O=C(c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL385153 141613 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.4 O=C(c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
10652140 101842 None 0 Mouse Binding pKi = 7.8 7.8 177 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 7 7 4.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL300456 101842 None 0 Mouse Binding pKi = 7.8 7.8 177 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 679 11 7 7 4.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
44403984 12309 None 0 Mouse Binding pKi = 7.8 7.8 125 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1185003 12309 None 0 Mouse Binding pKi = 7.8 7.8 125 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067967 12309 None 0 Mouse Binding pKi = 7.8 7.8 125 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(CC12CC3CC(CC(C3)C1)C2)C(=O)c1cc2[nH]cnc2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
10819816 118739 None 0 Rat Binding pKi = 6.8 6.8 -7 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 998 28 10 13 0.4 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL341762 118739 None 0 Rat Binding pKi = 6.8 6.8 -7 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 998 28 10 13 0.4 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
73354497 89383 None 0 Rat Binding pKi = 6.8 6.8 -7 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 998 28 10 13 0.4 CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL2369817 89383 None 0 Rat Binding pKi = 6.8 6.8 -7 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 998 28 10 13 0.4 CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL262172 210526 None 0 Human Binding pKi = 6.8 6.8 -691 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44408526 136943 None 0 Human Binding pKi = 5.8 5.8 -1862 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL374325 136943 None 0 Human Binding pKi = 5.8 5.8 -1862 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1148 30 11 15 3.0 CCCC[C@@H](C(=O)N[C@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
44346825 114771 None 0 Mouse Binding pKi = 6.8 6.8 77 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
CHEMBL333920 114771 None 0 Mouse Binding pKi = 6.8 6.8 77 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
44215880 69406 None 0 Human Binding pKi = 4.8 4.8 -3890 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL1933100 69406 None 0 Human Binding pKi = 4.8 4.8 -3890 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 441 8 4 3 4.2 O=C(Nc1ccccc1C(=O)NC(CCc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
44280199 99589 None 0 Rat Binding pKi = 5.8 5.8 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 681 8 2 6 6.9 COC(=O)[C@H]1C[C@@H](Oc2ccc(Cl)cc2Cl)CCN1C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(98)00231-5
CHEMBL283913 99589 None 0 Rat Binding pKi = 5.8 5.8 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 681 8 2 6 6.9 COC(=O)[C@H]1C[C@@H](Oc2ccc(Cl)cc2Cl)CCN1C(=O)[C@@](C)(Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1016/s0960-894x(98)00231-5
44347144 113064 None 0 Mouse Binding pKi = 5.8 5.8 12 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 512 6 2 4 4.0 COC(=O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL331177 113064 None 0 Mouse Binding pKi = 5.8 5.8 12 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 512 6 2 4 4.0 COC(=O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
44342477 110521 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1021/jm9703247
CHEMBL325070 110521 None 0 Rat Binding pKi = 5.8 5.8 - 1
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 588 8 3 6 3.9 COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@@H](NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)OC(C)(C)C)CCCN2C1=O 10.1021/jm9703247
11556194 197557 None 0 Human Binding pKi = 6.8 6.8 3 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
CHEMBL570297 197557 None 0 Human Binding pKi = 6.8 6.8 3 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
45486958 197586 None 0 Human Binding pKi = 6.8 6.8 19 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL570518 197586 None 0 Human Binding pKi = 6.8 6.8 19 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11420366 80337 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 486 6 1 7 4.4 O=C(c1ccc(OC2CCCC2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL214277 80337 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 486 6 1 7 4.4 O=C(c1ccc(OC2CCCC2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
16090788 80612 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 478 5 1 6 4.8 O=C(c1ccc(-c2ccccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL215111 80612 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 478 5 1 6 4.8 O=C(c1ccc(-c2ccccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11316813 82129 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 447 5 1 8 3.0 O=C(c1ccc([N+](=O)[O-])cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL216707 82129 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 447 5 1 8 3.0 O=C(c1ccc([N+](=O)[O-])cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
16090685 97076 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(Br)c2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL267290 97076 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 558 4 1 6 4.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(Br)c2nsnc12)N1CCCCC1 10.1021/jm060590x
11293780 141629 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL385285 141629 None 0 Human Binding pKi = 6.8 6.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
11576933 12266 None 0 Mouse Binding pKi = 6.8 6.8 19 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 499 7 4 4 5.5 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184725 12266 None 0 Mouse Binding pKi = 6.8 6.8 19 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 499 7 4 4 5.5 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067957 12266 None 0 Mouse Binding pKi = 6.8 6.8 19 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 499 7 4 4 5.5 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
19043361 4617 None 0 Human Binding pKi = 5.8 5.8 -162 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 524 6 2 3 6.2 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)c(Cl)cc21 10.1016/0960-894X(95)00528-2
CHEMBL102867 4617 None 0 Human Binding pKi = 5.8 5.8 -162 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 524 6 2 3 6.2 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)c(Cl)cc21 10.1016/0960-894X(95)00528-2
45486969 197468 None 0 Human Binding pKi = 5.8 5.8 -7 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
CHEMBL569849 197468 None 0 Human Binding pKi = 5.8 5.8 -7 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 598 8 3 7 5.4 C[C@H](c1ccc(Cl)c(Cl)c1)[C@@H](NC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)C(=O)O 10.1016/j.bmcl.2009.09.064
11584582 198866 None 0 Human Binding pKi = 5.8 5.8 -19 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
CHEMBL584063 198866 None 0 Human Binding pKi = 5.8 5.8 -19 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
25033153 94519 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 4 1 6 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(Cl)nc2sccn12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251684 94519 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 4 1 6 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(Cl)nc2sccn12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033227 154733 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 486 5 1 6 3.7 COC(=O)c1sccc1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL399918 154733 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 486 5 1 6 3.7 COC(=O)c1sccc1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090658 141516 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1021/jm060590x
CHEMBL384573 141516 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1021/jm060590x
16090792 141834 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 408 4 1 6 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC1 10.1021/jm060590x
CHEMBL386436 141834 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 408 4 1 6 3.0 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC1 10.1021/jm060590x
25033066 95903 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 462 4 2 4 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2[nH]cnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL259224 95903 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 462 4 2 4 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2[nH]cnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
16090658 141516 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL384573 141516 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 420 4 1 6 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nonc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
16732750 143981 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 7 2 5 4.2 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)N2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL390275 143981 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 7 2 5 4.2 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)N2CCCC2)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
44580900 188438 None 0 Human Binding pKi = 7.8 7.8 -2 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL502398 188438 None 0 Human Binding pKi = 7.8 7.8 -2 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
10771043 26151 None 0 Mouse Binding pKi = 7.8 7.8 61 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm00021a019
CHEMBL135658 26151 None 0 Mouse Binding pKi = 7.8 7.8 61 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm00021a019
11628273 140132 None 0 Human Binding pKi = 7.8 7.8 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380193 140132 None 0 Human Binding pKi = 7.8 7.8 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 559 7 1 6 5.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N3CCOCC3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
16733791 13180 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ncn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1190963 13180 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ncn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL541904 13180 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3ncn(CC(=O)O)c3c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44331524 163664 None 0 Human Binding pKi = 7.8 7.8 13 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 530 8 2 3 6.5 CC(CC1CCCC1)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(C(C)CC2CCCC2)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL420459 163664 None 0 Human Binding pKi = 7.8 7.8 13 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 530 8 2 3 6.5 CC(CC1CCCC1)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(C(C)CC2CCCC2)c2ccccc21 10.1016/S0960-894X(96)00544-6
49798104 10843 None 0 Human Binding pKi = 6.8 6.8 7 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL1172244 10843 None 0 Human Binding pKi = 6.8 6.8 7 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL 1381 39 14 13 3.5 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)N(c1ccccc1)C1CCN(CCc2ccccc2)CC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
CHEMBL3350335 211472 None 0 Human Binding pKi = 6.8 6.8 245 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
10819755 165440 None 0 Rat Binding pKi = 5.8 5.8 -52480 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL423907 165440 None 0 Rat Binding pKi = 5.8 5.8 -52480 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
44344617 114191 None 0 Mouse Binding pKi = 5.8 5.8 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 8 2 5 5.2 CCC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL332949 114191 None 0 Mouse Binding pKi = 5.8 5.8 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 8 2 5 5.2 CCC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
14802522 59570 None 0 Mouse Binding pKi = 6.8 6.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL171806 59570 None 0 Mouse Binding pKi = 6.8 6.8 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
3476 1399 None 9 Human Binding pKi = 6.8 6.8 -117 3
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
59751 1399 None 9 Human Binding pKi = 6.8 6.8 -117 3
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
878 1399 None 9 Human Binding pKi = 6.8 6.8 -117 3
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
CHEMBL39263 1399 None 9 Human Binding pKi = 6.8 6.8 -117 3
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 10.1021/jm200438b
52949124 875 None 4 Human Binding pKi = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pKi = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pKi = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pKi = 6.8 6.8 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL3351058 211538 None 0 Human Binding pKi = 7.8 7.8 83 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C1CCCCC1 10.1021/jm00053a022
10676196 119238 None 0 Mouse Binding pKi = 7.8 7.8 234 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 699 11 5 5 6.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL343515 119238 None 0 Mouse Binding pKi = 7.8 7.8 234 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 699 11 5 5 6.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
44351444 116884 None 0 Human Binding pKi = 7.8 7.8 -1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 116884 None 0 Human Binding pKi = 7.8 7.8 -1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
44356666 168627 None 0 Mouse Binding pKi = 7.8 7.8 16 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 799 11 3 11 5.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-n2cnnn2)cc(-n2cnnn2)c1 10.1021/jm00021a019
CHEMBL436187 168627 None 0 Mouse Binding pKi = 7.8 7.8 16 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 799 11 3 11 5.2 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-n2cnnn2)cc(-n2cnnn2)c1 10.1021/jm00021a019
11571142 135804 None 0 Mouse Binding pKi = 7.8 7.8 -10 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
CHEMBL373050 135804 None 0 Mouse Binding pKi = 7.8 7.8 -10 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 489 7 3 3 6.7 CC1(c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)CCCCC1 10.1021/jm0490686
CHEMBL3351060 211539 None 0 Human Binding pKi = 6.8 6.8 -20 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)c1ccccc1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL379405 212263 None 0 Human Binding pKi = 5.8 5.8 -10 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44408411 161308 None 0 Human Binding pKi = 5.8 5.8 -3548 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
CHEMBL412331 161308 None 0 Human Binding pKi = 5.8 5.8 -3548 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1242 31 11 15 4.4 CCCC[C@@H](C(=O)N[C@@H](Cc1cn(C(C)=O)c2ccccc12)C(=O)O)N(C(=O)Nc1ccccc1Cl)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)N(C)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050851n
10645976 16592 None 0 Human Binding pKi = 4.8 4.8 -23988 5
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 423 5 1 4 4.9 CN1c2ccc(Cl)cc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
CHEMBL124015 16592 None 0 Human Binding pKi = 4.8 4.8 -23988 5
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 423 5 1 4 4.9 CN1c2ccc(Cl)cc2C(c2ccccc2)=NCC1CCNC(=O)c1cccs1 10.1021/jm950423p
10555325 12947 None 0 Mouse Binding pKi = 6.8 6.8 45 2
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118930 12947 None 0 Mouse Binding pKi = 6.8 6.8 45 2
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
44280162 99454 None 0 Rat Binding pKi = 6.8 6.8 21 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL283040 99454 None 0 Rat Binding pKi = 6.8 6.8 21 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10747345 116976 None 0 Mouse Binding pKi = 6.8 6.8 6 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccccc1NC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL338728 116976 None 0 Mouse Binding pKi = 6.8 6.8 6 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 707 10 4 4 6.9 O=C(O)c1ccccc1NC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
10327028 89453 None 0 Rat Binding pKi = 7.8 7.8 -1 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371222 89453 None 0 Rat Binding pKi = 7.8 7.8 -1 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
44387568 62205 None 0 Rat Binding pKi = 7.8 7.8 -1 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
CHEMBL177799 62205 None 0 Rat Binding pKi = 7.8 7.8 -1 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 660 11 7 6 2.0 C[C@@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm0000416
5311201 207393 None 35 Human Binding pKi = 7.8 7.8 -27 6
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL9387 207393 None 35 Human Binding pKi = 7.8 7.8 -27 6
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm800174p
CHEMBL1172251 208581 None 0 Human Binding pKi = 7.8 7.8 -2 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
10257865 208436 None 4 Rat Binding pKi = 7.7 7.7 -3 5
Tested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 208436 None 4 Rat Binding pKi = 7.7 7.7 -3 5
Tested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards CCK-B in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
10793952 102779 None 0 Rat Binding pKi = 7.7 7.7 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL30524 102779 None 0 Rat Binding pKi = 7.7 7.7 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 621 8 3 5 5.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351444 116884 None 0 Rat Binding pKi = 7.7 7.7 1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 116884 None 0 Rat Binding pKi = 7.7 7.7 1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL1172428 208584 None 0 Human Binding pKi = 6.8 6.8 -47 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
57395574 68404 None 0 Human Binding pKi = 4.8 4.8 - 1
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 817 26 7 10 2.8 CCCCc1cn(CCCCCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)nn1 10.1016/j.bmc.2011.08.053
CHEMBL1917060 68404 None 0 Human Binding pKi = 4.8 4.8 - 1
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 817 26 7 10 2.8 CCCCc1cn(CCCCCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)nn1 10.1016/j.bmc.2011.08.053
11562579 132742 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 8 3 4 6.5 COc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL369974 132742 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 513 8 3 4 6.5 COc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
9983949 207739 None 0 Human Binding pKi = 6.7 6.7 23 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 513 9 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCCc1ccccc1 10.1021/jm00072a005
CHEMBL95793 207739 None 0 Human Binding pKi = 6.7 6.7 23 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 513 9 3 3 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCCc1ccccc1 10.1021/jm00072a005
10460621 107176 None 0 Human Binding pKi = 6.7 6.7 8 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)c(Cl)c1 10.1021/jm00072a005
CHEMBL316462 107176 None 0 Human Binding pKi = 6.7 6.7 8 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)c(Cl)c1 10.1021/jm00072a005
11539356 71678 None 0 Mouse Binding pKi = 6.7 6.7 -8 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL196441 71678 None 0 Mouse Binding pKi = 6.7 6.7 -8 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 7 3 3 5.6 CC(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
10841267 171516 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL446414 171516 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10626664 110385 None 0 Rat Binding pKi = 5.7 5.7 - 1
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
CHEMBL324294 110385 None 0 Rat Binding pKi = 5.7 5.7 - 1
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
CHEMBL120632 208603 None 33 Human Binding pKi = 7.7 7.7 5 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
9832467 144291 None 0 Human Binding pKi = 7.7 7.7 -22 5
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL390519 144291 None 0 Human Binding pKi = 7.7 7.7 -22 5
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 477 7 3 4 5.9 O=C(O)c1cccc(NC(=O)c2nc(C3CCCCC3)[nH]c2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm070139l
CHEMBL120632 208603 None 33 Human Binding pKi = 7.7 7.7 5 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm9603072
44351455 116817 None 0 Rat Binding pKi = 7.7 7.7 1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337934 116817 None 0 Rat Binding pKi = 7.7 7.7 1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL1172429 208585 None 0 Human Binding pKi = 6.7 6.7 -120 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
9957602 155386 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL40352 155386 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)NCCc1ccccc1 10.1021/jm00087a011
44346908 16453 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 526 6 2 4 4.4 COC(=O)[C@H](C)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL123344 16453 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 526 6 2 4 4.4 COC(=O)[C@H](C)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
44346909 114581 None 0 Mouse Binding pKi = 5.7 5.7 10 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 498 6 3 3 3.9 O=C(O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL333758 114581 None 0 Mouse Binding pKi = 5.7 5.7 10 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 498 6 3 3 3.9 O=C(O)CNC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
11705988 166350 None 0 Human Binding pKi = 6.7 6.7 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL427387 166350 None 0 Human Binding pKi = 6.7 6.7 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 498 7 2 6 4.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
44346355 157865 None 0 Rat Binding pKi = 6.7 6.7 -30 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL408389 157865 None 0 Rat Binding pKi = 6.7 6.7 -30 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
16090649 82471 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 4 1 6 3.9 C[C@H]1C=C[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL217648 82471 None 0 Human Binding pKi = 6.7 6.7 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 448 4 1 6 3.9 C[C@H]1C=C[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
9936141 12260 None 0 Mouse Binding pKi = 6.7 6.7 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 510 7 4 3 7.0 O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184700 12260 None 0 Mouse Binding pKi = 6.7 6.7 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 510 7 4 3 7.0 O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067956 12260 None 0 Mouse Binding pKi = 6.7 6.7 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 510 7 4 3 7.0 O=C(O)c1cc(NC(=O)c2cc(-c3ccc4ccccc4c3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
11605951 12284 None 0 Mouse Binding pKi = 6.7 6.7 25 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 512 8 4 3 6.5 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184851 12284 None 0 Mouse Binding pKi = 6.7 6.7 25 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 512 8 4 3 6.5 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067961 12284 None 0 Mouse Binding pKi = 6.7 6.7 25 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 512 8 4 3 6.5 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
44445282 94515 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 481 5 1 5 4.1 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.087
CHEMBL251651 94515 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 481 5 1 5 4.1 Cc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cc1[N+](=O)[O-] 10.1016/j.bmcl.2007.09.087
16090700 82461 None 0 Human Binding pKi = 5.7 5.7 -10 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 541 8 4 4 4.2 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
CHEMBL217595 82461 None 0 Human Binding pKi = 5.7 5.7 -10 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 541 8 4 4 4.2 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
16090702 166196 None 0 Human Binding pKi = 5.7 5.7 -1 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 461 4 2 3 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 10.1021/jm060590x
CHEMBL426524 166196 None 0 Human Binding pKi = 5.7 5.7 -1 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 461 4 2 3 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cc2ccccc2[nH]1)N1CCCCC1 10.1021/jm060590x
25033064 96016 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nnc2c(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)cccc21 10.1016/j.bmc.2008.01.059
CHEMBL259751 96016 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nnc2c(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)cccc21 10.1016/j.bmc.2008.01.059
5311201 207393 None 35 Human Binding pKi = 8.7 8.7 -27 6
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
CHEMBL9387 207393 None 35 Human Binding pKi = 8.7 8.7 -27 6
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm970439a
118718859 115417 None 1 Mouse Binding pKi = 8.7 8.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3350364 115417 None 1 Mouse Binding pKi = 8.7 8.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 616 12 5 5 5.2 CC1(C)[C@H]2CC[C@@]1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
44346326 113337 None 0 Human Binding pKi = 8.7 8.7 46 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 588 5 2 7 6.5 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
CHEMBL331688 113337 None 0 Human Binding pKi = 8.7 8.7 46 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 588 5 2 7 6.5 O=C(Nc1cccc(C2N=NN=N2)c1)NC1C(=O)N(c2ccccc2)c2ccccc2N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)C1=O 10.1021/jm990967h
10576324 113962 None 0 Human Binding pKi = 8.7 8.7 54 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.3 CC(C)CC(C)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL332595 113962 None 0 Human Binding pKi = 8.7 8.7 54 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 470 6 2 3 5.3 CC(C)CC(C)N1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL265595 210653 None 0 Human Binding pKi = 8.7 8.7 120 4
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm0303103
CHEMBL411201 212870 None 0 Human Binding pKi = 8.7 8.7 3 4
Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determinedBinding affinity towards Cholecystokinin type B receptor (CCK-B) receptor was determined
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm0303103
CHEMBL407057 212633 None 0 Human Binding pKi = 8.7 8.7 120 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O 10.1021/jm050921q
16732909 85455 None 0 Human Binding pKi = 8.7 8.7 2 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226673 85455 None 0 Human Binding pKi = 8.7 8.7 2 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 5 5.1 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
15755206 115474 None 0 Mouse Binding pKi = 8.7 8.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 11 5 5 5.0 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351023 115474 None 0 Mouse Binding pKi = 8.7 8.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 11 5 5 5.0 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@](C)(Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
44356825 168631 None 0 Mouse Binding pKi = 8.7 8.7 1621 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 767 11 6 6 6.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL436209 168631 None 0 Mouse Binding pKi = 8.7 8.7 1621 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 767 11 6 6 6.3 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
5311201 207393 None 35 Human Binding pKi = 8.7 8.7 -27 6
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
CHEMBL9387 207393 None 35 Human Binding pKi = 8.7 8.7 -27 6
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00053a022
11547802 136001 None 0 Mouse Binding pKi = 8.7 8.7 177 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 8 3 3 6.4 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL373168 136001 None 0 Mouse Binding pKi = 8.7 8.7 177 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 8 3 3 6.4 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
9850043 112554 None 2 Human Binding pKi = 8.6 8.6 309 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL329984 112554 None 2 Human Binding pKi = 8.6 8.6 309 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O 10.1016/S0960-894X(96)00544-6
9850043 112871 None 2 Human Binding pKi = 8.6 8.6 1 3
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 112871 None 2 Human Binding pKi = 8.6 8.6 1 3
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44356887 31315 None 0 Mouse Binding pKi = 8.6 8.6 776 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 6 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccsc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL140179 31315 None 0 Mouse Binding pKi = 8.6 8.6 776 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 6 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccsc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
10745516 14355 None 0 Human Binding pKi = 8.6 8.6 60 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 563 5 2 4 5.8 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)C2=O)c1 10.1021/jm990967h
CHEMBL120015 14355 None 0 Human Binding pKi = 8.6 8.6 60 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 563 5 2 4 5.8 CN(C)c1cccc(NC(=O)NC2C(=O)N(c3ccccc3)c3ccccc3N(C3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)C2=O)c1 10.1021/jm990967h
44331505 4351 None 0 Human Binding pKi = 8.6 8.6 25 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 450 8 2 3 4.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL101063 4351 None 0 Human Binding pKi = 8.6 8.6 25 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 450 8 2 3 4.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
10256780 112677 None 0 Human Binding pKi = 8.6 8.6 234 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 540 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL330409 112677 None 0 Human Binding pKi = 8.6 8.6 234 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 540 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00544-6
10603576 14510 None 0 Human Binding pKi = 8.6 8.6 19 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 8 2 7 5.6 CC(C)Cn1nnc(-c2cccc(NC(=O)NC3C(=O)N(CCC(C)(C)C)c4ccccc4N(c4ccccc4)C3=O)c2)n1 10.1021/jm990967h
CHEMBL120168 14510 None 0 Human Binding pKi = 8.6 8.6 19 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 8 2 7 5.6 CC(C)Cn1nnc(-c2cccc(NC(=O)NC3C(=O)N(CCC(C)(C)C)c4ccccc4N(c4ccccc4)C3=O)c2)n1 10.1021/jm990967h
9914672 108540 None 0 Human Binding pKi = 8.6 8.6 31 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/j.bmc.2007.12.047
CHEMBL320141 108540 None 0 Human Binding pKi = 8.6 8.6 31 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/j.bmc.2007.12.047
9914672 108540 None 0 Human Binding pKi = 8.6 8.6 31 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
CHEMBL320141 108540 None 0 Human Binding pKi = 8.6 8.6 31 2
Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)Tested for its selectivity against human Cholecystokinin type B receptor isolated from a human temporal cortex cDNA library and stably transfected into a HeLa cell line. (n=1)
ChEMBL 521 5 2 4 3.7 O=C(Nc1ccc(F)cc1)N[C@H]1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(C2CCCCC2)C1=O 10.1016/S0960-894X(96)00613-0
10699583 96409 None 0 Human Binding pKi = 8.6 8.6 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 664 19 6 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COC 10.1021/jm0000416
CHEMBL261934 96409 None 0 Human Binding pKi = 8.6 8.6 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 664 19 6 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COC 10.1021/jm0000416
44331489 4273 None 0 Human Binding pKi = 8.6 8.6 32 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 493 9 2 4 4.7 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100618 4273 None 0 Human Binding pKi = 8.6 8.6 32 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 493 9 2 4 4.7 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL333477 211390 None 0 Rat Binding pKi = 8.6 8.6 -19 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm0000416
10795116 27913 None 0 Mouse Binding pKi = 8.6 8.6 602 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2ccc3ccccc3c2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL137180 27913 None 0 Mouse Binding pKi = 8.6 8.6 602 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 743 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCc2ccc3ccccc3c2)cc(C(=O)O)c1 10.1021/jm00021a019
11803482 117198 None 0 Human Binding pKi = 8.6 8.6 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
CHEMBL339421 117198 None 0 Human Binding pKi = 8.6 8.6 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
CHEMBL205965 209167 None 0 Human Binding pKi = 8.6 8.6 31 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
16732594 14365 None 0 Human Binding pKi = 8.6 8.6 2511 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1161950 14365 None 0 Human Binding pKi = 8.6 8.6 2511 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1200187 14365 None 0 Human Binding pKi = 8.6 8.6 2511 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2cnn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL3351053 211535 None 0 Human Binding pKi = 8.6 8.6 426 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
4627 821 None 50 Rat Binding pKi = 8.6 8.6 1 5
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
864 821 None 50 Rat Binding pKi = 8.6 8.6 1 5
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
9833444 821 None 50 Rat Binding pKi = 8.6 8.6 1 5
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
CHEMBL1121 821 None 50 Rat Binding pKi = 8.6 8.6 1 5
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
DB09142 821 None 50 Rat Binding pKi = 8.6 8.6 1 5
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL None None None None 10.1021/jm9703247
9850043 112871 None 2 Rat Binding pKi = 8.6 8.6 -1 3
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 112871 None 2 Rat Binding pKi = 8.6 8.6 -1 3
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10626579 15509 None 0 Human Binding pKi = 8.5 8.5 38 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 554 6 2 4 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(OC(F)(F)F)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL121703 15509 None 0 Human Binding pKi = 8.5 8.5 38 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 554 6 2 4 6.2 CC(C)(C)CCN1C(=O)C(NC(=O)Nc2cccc(OC(F)(F)F)c2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
10651325 13876 None 0 Human Binding pKi = 8.5 8.5 275 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 606 7 2 5 6.3 CCOC(=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL119608 13876 None 0 Human Binding pKi = 8.5 8.5 275 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 606 7 2 5 6.3 CCOC(=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
5311201 207393 None 35 Human Binding pKi = 8.5 8.5 -27 6
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
CHEMBL9387 207393 None 35 Human Binding pKi = 8.5 8.5 -27 6
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
44351491 116900 None 0 Human Binding pKi = 7.7 7.7 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 570 7 3 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338382 116900 None 0 Human Binding pKi = 7.7 7.7 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 570 7 3 5 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10256428 115469 None 0 Mouse Binding pKi = 7.7 7.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3351017 115469 None 0 Mouse Binding pKi = 7.7 7.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
11513177 72527 None 0 Mouse Binding pKi = 7.7 7.7 -8 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL199091 72527 None 0 Mouse Binding pKi = 7.7 7.7 -8 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
16731870 97397 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 8 2 4 5.6 CC(C)CCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL269790 97397 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 490 8 2 4 5.6 CC(C)CCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
136036821 95806 None 0 Human Binding pKi = 7.7 7.7 3 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL258782 95806 None 0 Human Binding pKi = 7.7 7.7 3 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 602 9 2 7 5.6 CC(C)(C)C(=O)CN1C(=O)N(CCCC(=O)Nc2cccc(-c3nc(=O)o[nH]3)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
10257865 208436 None 4 Rat Binding pKi = 7.7 7.7 -3 5
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 208436 None 4 Rat Binding pKi = 7.7 7.7 -3 5
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
90662930 106569 None 0 Rat Binding pKi = 6.7 6.7 -3981 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1073 29 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3142366 106569 None 0 Rat Binding pKi = 6.7 6.7 -3981 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1073 29 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)NC(=O)c1ccccc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL2372623 210275 None 0 Human Binding pKi = 6.7 6.7 -218 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
11664728 134419 None 0 Mouse Binding pKi = 6.7 6.7 10 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 482 7 3 2 7.1 Cc1ccccc1-c1cc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL371750 134419 None 0 Mouse Binding pKi = 6.7 6.7 10 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 482 7 3 2 7.1 Cc1ccccc1-c1cc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
15024387 115421 None 0 Mouse Binding pKi = 5.7 5.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3350393 115421 None 0 Mouse Binding pKi = 5.7 5.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
15513851 114956 None 0 Mouse Binding pKi = 5.7 5.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccc(F)cc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL334247 114956 None 0 Mouse Binding pKi = 5.7 5.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccc(F)cc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10258121 98571 None 0 Human Binding pKi = 4.7 4.7 -11 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 606 11 4 2 7.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL276676 98571 None 0 Human Binding pKi = 4.7 4.7 -11 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 606 11 4 2 7.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
10257865 208436 None 4 Mouse Binding pKi = 7.7 7.7 -2 5
Tested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligandTested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 208436 None 4 Mouse Binding pKi = 7.7 7.7 -2 5
Tested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligandTested for binding affinity towards CCK-B in mouse brain by displacement of [3H]-pBC264 radioligand
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
10413618 202789 None 0 Mouse Binding pKi = 7.7 7.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL62205 202789 None 0 Mouse Binding pKi = 7.7 7.7 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
44580901 169465 None 0 Human Binding pKi = 6.7 6.7 -3 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL442943 169465 None 0 Human Binding pKi = 6.7 6.7 -3 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
46235271 73646 None 2 Human Binding pKi = 6.7 6.7 -2 2
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pKi = 6.7 6.7 -2 2
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
44346826 113812 None 0 Mouse Binding pKi = 6.7 6.7 69 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 3.9 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL332510 113812 None 0 Mouse Binding pKi = 6.7 6.7 69 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 3.9 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
15513852 11189 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2cccc(F)c2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL117868 11189 None 0 Mouse Binding pKi = 6.7 6.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2cccc(F)c2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
15513857 114535 None 0 Mouse Binding pKi = 5.7 5.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 1 6 4.3 COC(=O)CNC(=O)[C@@H]1CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@@H](CC23CC4CC(CC(C4)C2)C3)N1C(C)=O 10.1021/jm000960w
CHEMBL333623 114535 None 0 Mouse Binding pKi = 5.7 5.7 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 1 6 4.3 COC(=O)CNC(=O)[C@@H]1CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@@H](CC23CC4CC(CC(C4)C2)C3)N1C(C)=O 10.1021/jm000960w
9853654 22787 None 41 Human Binding pKi = 7.7 7.7 31 2
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80686-1
CHEMBL1328 22787 None 41 Human Binding pKi = 7.7 7.7 31 2
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80686-1
CHEMBL3142842 211133 None 0 Human Binding pKi = 5.7 5.7 2 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
10581797 63242 None 0 Rat Binding pKi = 5.7 5.7 -9120 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 26 9 11 1.3 CC[C@H](C)[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/jm970477u
CHEMBL1791002 63242 None 0 Rat Binding pKi = 5.7 5.7 -9120 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 26 9 11 1.3 CC[C@H](C)[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)[C@@H](C)CC 10.1021/jm970477u
CHEMBL205306 209166 None 0 Human Binding pKi = 5.7 5.7 -109 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10071178 74493 None 2 Human Binding pKi = 4.7 4.7 -501 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 427 7 4 3 3.8 O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
CHEMBL202861 74493 None 2 Human Binding pKi = 4.7 4.7 -501 2
Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma countingDisplacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting
ChEMBL 427 7 4 3 3.8 O=C(Nc1ccccc1C(=O)NC(Cc1ccccc1)C(=O)O)c1cc2ccccc2[nH]1 10.1021/jm200438b
44580901 169465 None 0 Human Binding pKi = 6.7 6.7 -3 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL442943 169465 None 0 Human Binding pKi = 6.7 6.7 -3 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 843 12 6 11 2.8 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
44332766 108334 None 0 Human Binding pKi = 6.7 6.7 -48 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(F)ccc21 10.1016/0960-894X(95)00528-2
CHEMBL319795 108334 None 0 Human Binding pKi = 6.7 6.7 -48 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(F)ccc21 10.1016/0960-894X(95)00528-2
10794262 168626 None 0 Mouse Binding pKi = 6.7 6.7 6 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL436175 168626 None 0 Mouse Binding pKi = 6.7 6.7 6 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
9919500 204923 None 3 Rat Binding pKi = 6.7 6.7 -7413 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL1161142 204923 None 3 Rat Binding pKi = 6.7 6.7 -7413 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL76248 204923 None 3 Rat Binding pKi = 6.7 6.7 -7413 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
9919500 204923 None 3 Rat Binding pKi = 6.7 6.7 -7413 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL1161142 204923 None 3 Rat Binding pKi = 6.7 6.7 -7413 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL76248 204923 None 3 Rat Binding pKi = 6.7 6.7 -7413 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
44329398 207686 None 0 Human Binding pKi = 6.7 6.7 12 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 543 10 3 4 4.8 O=C(O)CN(CCc1ccccc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
CHEMBL95461 207686 None 0 Human Binding pKi = 6.7 6.7 12 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 543 10 3 4 4.8 O=C(O)CN(CCc1ccccc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
CHEMBL332180 211383 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O 10.1021/jm0000416
10794634 113100 None 0 Human Binding pKi = 4.6 4.6 -11220 2
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
CHEMBL331394 113100 None 0 Human Binding pKi = 4.6 4.6 -11220 2
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 677 19 7 7 0.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(N)=O 10.1021/jm0000416
73347063 89452 None 0 Rat Binding pKi = 7.6 7.6 -1 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371221 89452 None 0 Rat Binding pKi = 7.6 7.6 -1 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 674 11 7 6 2.4 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
9939572 37489 None 0 Rat Binding pKi = 7.6 7.6 -21 3
Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/0960-894X(96)00192-8
CHEMBL14557 37489 None 0 Rat Binding pKi = 7.6 7.6 -21 3
Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/0960-894X(96)00192-8
CHEMBL2067949 37489 None 0 Rat Binding pKi = 7.6 7.6 -21 3
Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.Compound was tested for binding affinity against Cholecystokinin type B receptor in rat cortical membranes using L-365260 as the radioligand.
ChEMBL 662 11 6 5 5.5 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3cc[nH]c3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1016/0960-894X(96)00192-8
44451522 158312 None 0 Human Binding pKi = 7.6 7.6 26 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 6 1 4 5.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL408915 158312 None 0 Human Binding pKi = 7.6 7.6 26 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 531 6 1 4 5.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)N3CCCC3)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL123056 208644 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC 10.1021/jm0000416
16732442 85492 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227097 85492 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 2 5 4.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCC2)c2ccccc21 10.1021/jm070139l
16731711 85517 None 0 Human Binding pKi = 7.6 7.6 15 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 7 2 5 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1021/jm070139l
CHEMBL227369 85517 None 0 Human Binding pKi = 7.6 7.6 15 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 570 7 2 5 5.8 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1021/jm070139l
10390666 208303 None 0 Human Binding pKi = 6.6 6.6 17 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 485 7 3 3 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCc1ccccc1 10.1021/jm00072a005
CHEMBL99076 208303 None 0 Human Binding pKi = 6.6 6.6 17 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 485 7 3 3 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCc1ccccc1 10.1021/jm00072a005
11567687 135935 None 0 Mouse Binding pKi = 5.6 5.6 -1 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL373125 135935 None 0 Mouse Binding pKi = 5.6 5.6 -1 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 407 6 3 3 4.8 Cc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
11801718 99805 None 0 Rat Binding pKi = 7.6 7.6 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 599 9 3 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL285419 99805 None 0 Rat Binding pKi = 7.6 7.6 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 599 9 3 5 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351519 168517 None 0 Human Binding pKi = 7.6 7.6 1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL435404 168517 None 0 Human Binding pKi = 7.6 7.6 1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351492 117923 None 0 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 600 9 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL340327 117923 None 0 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 600 9 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351519 168517 None 0 Rat Binding pKi = 7.6 7.6 -1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL435404 168517 None 0 Rat Binding pKi = 7.6 7.6 -1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 620 8 3 6 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
52949124 875 None 4 Human Binding pKi = 7.6 7.6 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pKi = 7.6 7.6 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pKi = 7.6 7.6 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pKi = 7.6 7.6 2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
904 3024 None 10 Mouse Binding pKi = 6.6 6.6 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
9915756 3024 None 10 Mouse Binding pKi = 6.6 6.6 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL2111204 3024 None 10 Mouse Binding pKi = 6.6 6.6 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
CHEMBL356898 3024 None 10 Mouse Binding pKi = 6.6 6.6 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 OC(=O)C[C@H](NC(=O)[C@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)Cc1ccccc1 10.1021/jm00087a011
10580492 14534 None 0 Human Binding pKi = 5.6 5.6 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
CHEMBL120257 14534 None 0 Human Binding pKi = 5.6 5.6 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 1
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C/C(=O)O 10.1021/jm0000416
10507109 109225 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL321761 109225 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 561 7 2 4 5.3 CC(C)N(C(=O)CN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
11540160 71446 None 0 Mouse Binding pKi = 7.6 7.6 -5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196133 71446 None 0 Mouse Binding pKi = 7.6 7.6 -5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 475 7 3 3 6.6 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
11693225 198799 None 0 Human Binding pKi = 7.6 7.6 7 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 676 8 3 7 4.8 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL583344 198799 None 0 Human Binding pKi = 7.6 7.6 7 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 676 8 3 7 4.8 O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
9913081 82429 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL217453 82429 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
9913081 82429 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL217453 82429 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
9913081 82429 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL217453 82429 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
44403980 11803 None 0 Mouse Binding pKi = 7.6 7.6 398 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1181938 11803 None 0 Mouse Binding pKi = 7.6 7.6 398 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067951 11803 None 0 Mouse Binding pKi = 7.6 7.6 398 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 5.2 CN(C(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)[C@@H](Cc1ccccc1)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
121964 207 None 34 Rat Binding pKi = 6.6 6.6 -831 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
858 207 None 34 Rat Binding pKi = 6.6 6.6 -831 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
CHEMBL323521 207 None 34 Rat Binding pKi = 6.6 6.6 -831 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None None 10.1021/jm990252e
45486947 196900 None 0 Human Binding pKi = 6.6 6.6 -1 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 654 8 2 7 5.2 COC(=O)[C@H](Cc1ccc(F)c(Br)c1)NC(=O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL566177 196900 None 0 Human Binding pKi = 6.6 6.6 -1 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 654 8 2 7 5.2 COC(=O)[C@H](Cc1ccc(F)c(Br)c1)NC(=O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
11396307 136541 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 430 5 1 6 3.7 CCc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL373703 136541 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 430 5 1 6 3.7 CCc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
11281656 141780 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 6 3.4 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCC1 10.1021/jm060590x
CHEMBL386143 141780 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 6 3.4 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCC1 10.1021/jm060590x
11518254 11799 None 0 Mouse Binding pKi = 6.6 6.6 31 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 460 7 4 3 5.8 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1181918 11799 None 0 Mouse Binding pKi = 6.6 6.6 31 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 460 7 4 3 5.8 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067948 11799 None 0 Mouse Binding pKi = 6.6 6.6 31 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 460 7 4 3 5.8 O=C(O)c1cc(NC(=O)c2cc(-c3ccccc3)[nH]c2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
9958028 11802 None 0 Mouse Binding pKi = 6.6 6.6 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 511 7 4 4 6.4 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1181937 11802 None 0 Mouse Binding pKi = 6.6 6.6 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 511 7 4 4 6.4 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067950 11802 None 0 Mouse Binding pKi = 6.6 6.6 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 511 7 4 4 6.4 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm049069y
16090692 82438 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL217492 82438 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11699148 75979 None 0 Human Binding pKi = 5.6 5.6 -2 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
CHEMBL205423 75979 None 0 Human Binding pKi = 5.6 5.6 -2 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 511 7 2 6 3.4 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)N3CCCC3)C2=O)c1 10.1021/jm051219x
25033229 154499 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 494 4 1 5 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2c(c1)OCCCO2)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL399059 154499 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 494 4 1 5 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2c(c1)OCCCO2)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090650 81058 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 451 4 1 7 2.5 CN1CCN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)CC1 10.1021/jm060590x
CHEMBL215415 81058 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 451 4 1 7 2.5 CN1CCN(C(=O)c2ccc(Cl)cc2NS(=O)(=O)c2cccc3nsnc23)CC1 10.1021/jm060590x
16090791 82116 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 462 6 1 8 3.1 COc1cc(NS(=O)(=O)c2cccc3nsnc23)c(C(=O)N2CCCCC2)cc1OC 10.1021/jm060590x
CHEMBL216623 82116 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 462 6 1 8 3.1 COc1cc(NS(=O)(=O)c2cccc3nsnc23)c(C(=O)N2CCCCC2)cc1OC 10.1021/jm060590x
16090692 82438 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL217492 82438 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 458 6 2 6 4.1 O=C(NCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
15297878 113092 None 0 Mouse Binding pKi = 5.6 5.6 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1cccc2ccccc12 10.1021/jm00048a001
CHEMBL331324 113092 None 0 Mouse Binding pKi = 5.6 5.6 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1cccc2ccccc12 10.1021/jm00048a001
CHEMBL382051 212291 None 0 Human Binding pKi = 7.6 7.6 -131 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
44351455 116817 None 0 Human Binding pKi = 7.6 7.6 -1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337934 116817 None 0 Human Binding pKi = 7.6 7.6 -1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 8 3 6 4.6 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44351446 156139 None 0 Human Binding pKi = 7.6 7.6 3 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 156139 None 0 Human Binding pKi = 7.6 7.6 3 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
11613179 71786 None 0 Mouse Binding pKi = 7.6 7.6 -3 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL196745 71786 None 0 Mouse Binding pKi = 7.6 7.6 -3 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 7 3 3 7.1 Cc1cc(C)c(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
11576771 74429 None 0 Human Binding pKi = 7.6 7.6 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL202680 74429 None 0 Human Binding pKi = 7.6 7.6 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 489 6 2 5 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(N)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
44580900 188438 None 0 Human Binding pKi = 6.6 6.6 -2 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL502398 188438 None 0 Human Binding pKi = 6.6 6.6 -2 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
15513860 113315 None 0 Mouse Binding pKi = 5.6 5.6 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 602 8 1 5 5.6 CC(=O)N1[C@H](C(=O)CCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL331560 113315 None 0 Mouse Binding pKi = 5.6 5.6 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 602 8 1 5 5.6 CC(=O)N1[C@H](C(=O)CCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
11698512 168253 None 0 Mouse Binding pKi = 6.6 6.6 -5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL433776 168253 None 0 Mouse Binding pKi = 6.6 6.6 -5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 435 8 3 3 5.5 CCCc1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
108187 925 None 37 Rat Binding pKi = 6.6 6.6 -295 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
873 925 None 37 Rat Binding pKi = 6.6 6.6 -295 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL2062154 925 None 37 Rat Binding pKi = 6.6 6.6 -295 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
CHEMBL287735 925 None 37 Rat Binding pKi = 6.6 6.6 -295 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm990967h
5311201 207393 None 35 Rat Binding pKi = 6.6 6.6 -234 6
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
CHEMBL9387 207393 None 35 Rat Binding pKi = 6.6 6.6 -234 6
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm990967h
443375 207604 None 45 Rat Binding pKi = 6.6 6.6 -389 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL9506 207604 None 45 Rat Binding pKi = 6.6 6.6 -389 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranesInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of rat pancreatic membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
11505466 72028 None 0 Mouse Binding pKi = 5.6 5.6 -2 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
CHEMBL197578 72028 None 0 Mouse Binding pKi = 5.6 5.6 -2 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 425 7 3 3 5.1 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCc2ccccc2)[nH]1 10.1021/jm0490686
10840341 12504 None 0 Mouse Binding pKi = 5.6 5.6 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 547 7 2 5 4.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCCC1 10.1021/jm000960w
CHEMBL118653 12504 None 0 Mouse Binding pKi = 5.6 5.6 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 547 7 2 5 4.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCCC1 10.1021/jm000960w
10099495 107731 None 0 Human Binding pKi = 7.6 7.6 117 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1Cl 10.1021/jm00072a005
CHEMBL319120 107731 None 0 Human Binding pKi = 7.6 7.6 117 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 567 8 3 3 6.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1Cl 10.1021/jm00072a005
44272156 141540 None 0 Human Binding pKi = 7.6 7.6 45 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL384731 141540 None 0 Human Binding pKi = 7.6 7.6 45 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11498528 72474 None 0 Mouse Binding pKi = 7.6 7.6 -38 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL198933 72474 None 0 Mouse Binding pKi = 7.6 7.6 -38 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 4 6.1 O=C(O)c1cccc(NC(=O)c2[nH]c(C34CCC(CC3)CC4)nc2COC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL383458 212311 None 0 Human Binding pKi = 5.6 5.6 -4 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm050921q
10840582 167977 None 0 Rat Binding pKi = 5.6 5.6 -257 2
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm9703247
CHEMBL431858 167977 None 0 Rat Binding pKi = 5.6 5.6 -257 2
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@H]12 10.1021/jm9703247
10698558 117219 None 0 Rat Binding pKi = 7.6 7.6 3 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL339451 117219 None 0 Rat Binding pKi = 7.6 7.6 3 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10579208 118384 None 0 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL341045 118384 None 0 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
44329798 107547 None 0 Rat Binding pKi = 7.6 7.6 -2 5
Tested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligand
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL318852 107547 None 0 Rat Binding pKi = 7.6 7.6 -2 5
Tested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat pancreas by displacement of [3H]pCCK-8 radioligand
ChEMBL 610 10 2 4 6.5 CC(Cc1c[nH]c2ccccc12)(C(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
44356886 28425 None 0 Mouse Binding pKi = 7.6 7.6 42 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](CC2CCCCC2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL137525 28425 None 0 Mouse Binding pKi = 7.6 7.6 42 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 757 11 5 5 7.3 O=C(O)c1cc(NC(=O)[C@@H](CC2CCCCC2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44331479 4370 None 0 Human Binding pKi = 7.5 7.5 27 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 494 9 1 5 4.7 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL101208 4370 None 0 Human Binding pKi = 7.5 7.5 27 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 494 9 1 5 4.7 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CCC(C)C)c2ccccc21 10.1016/S0960-894X(96)00544-6
10793450 117471 None 0 Human Binding pKi = 6.5 6.5 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL339931 117471 None 0 Human Binding pKi = 6.5 6.5 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
11512112 75590 None 0 Human Binding pKi = 6.5 6.5 -5 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
CHEMBL204683 75590 None 0 Human Binding pKi = 6.5 6.5 -5 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 8 2 6 4.9 CNc1cccc(NC(=O)CN2N=C(c3ccccn3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 10.1021/jm051219x
10618720 193789 None 0 Mouse Binding pKi = 5.5 5.5 4 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 363 4 2 2 4.5 O=C(O)c1cc2ccccc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
CHEMBL52740 193789 None 0 Mouse Binding pKi = 5.5 5.5 4 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 363 4 2 2 4.5 O=C(O)c1cc2ccccc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
44272042 97044 None 0 Human Binding pKi = 7.5 7.5 131 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL266990 97044 None 0 Human Binding pKi = 7.5 7.5 131 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11584903 140737 None 0 Human Binding pKi = 7.5 7.5 3 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL381805 140737 None 0 Human Binding pKi = 7.5 7.5 3 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 560 10 2 6 5.1 CNCCN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
443375 207604 None 45 Human Binding pKi = 7.5 7.5 -316 5
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL9506 207604 None 45 Human Binding pKi = 7.5 7.5 -316 5
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptorInhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL2370441 209849 None 0 Human Binding pKi = 6.5 6.5 2 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
5311188 9803 None 2 Rat Binding pKi = 5.5 5.5 1 2
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
CHEMBL113718 9803 None 2 Rat Binding pKi = 5.5 5.5 1 2
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 559 7 3 5 4.1 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCCN2C(=O)N(Cc3ccccc3)C(=O)C[C@@H]12 10.1021/jm9703247
11497371 70628 None 0 Mouse Binding pKi = 8.5 8.5 1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL195007 70628 None 0 Mouse Binding pKi = 8.5 8.5 1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 525 7 3 3 7.4 Cc1cc(C)c(-c2nc(C(=O)Nc3ccc(C)c(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
9939183 114126 None 0 Human Binding pKi = 8.5 8.5 6606 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 633 7 2 5 5.9 O=C(Nc1cccc(CN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL332850 114126 None 0 Human Binding pKi = 8.5 8.5 6606 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 633 7 2 5 5.9 O=C(Nc1cccc(CN2CCOCC2)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44451843 159437 None 0 Human Binding pKi = 8.5 8.5 13 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL410114 159437 None 0 Human Binding pKi = 8.5 8.5 13 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 8 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CC(=O)O)c2)C(=O)N(C2CCCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL3350335 211472 None 0 Human Binding pKi = 8.5 8.5 245 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
44357057 119218 None 0 Mouse Binding pKi = 8.5 8.5 446 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2F)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL343367 119218 None 0 Mouse Binding pKi = 8.5 8.5 446 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2ccccc2F)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
11555184 166030 None 0 Mouse Binding pKi = 8.5 8.5 -3 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL425574 166030 None 0 Mouse Binding pKi = 8.5 8.5 -3 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 503 7 3 3 7.0 Cc1ccc(NC(=O)c2[nH]c(C3(C)CCCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
44346176 113332 None 0 Human Binding pKi = 8.5 8.5 21 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 496 6 3 3 6.2 CC(CC1CCCC1)c1cccc2c1NC(=O)C(NC(=O)Nc1ccccc1)C(=O)N2c1ccccc1 10.1021/jm990967h
CHEMBL331651 113332 None 0 Human Binding pKi = 8.5 8.5 21 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 496 6 3 3 6.2 CC(CC1CCCC1)c1cccc2c1NC(=O)C(NC(=O)Nc1ccccc1)C(=O)N2c1ccccc1 10.1021/jm990967h
10628422 109171 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
CHEMBL321456 109171 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 6 8 0.9 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(=O)OC 10.1021/jm0000416
443375 207604 None 45 Human Binding pKi = 8.4 8.4 -316 5
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm950423p
CHEMBL9506 207604 None 45 Human Binding pKi = 8.4 8.4 -316 5
Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.Binding affinity against Cholecystokinin type B receptor using [3H](MeNLE28,31)-CCK-8 as radioligand in guinea pig cerebral cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm950423p
118727698 117589 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2392 78 21 30 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCn1cc(COc2cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
CHEMBL3400296 117589 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 2392 78 21 30 7.0 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCn1cc(COc2cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCc3cn(CCCCCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
10076872 115470 None 0 Mouse Binding pKi = 8.4 8.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 576 12 5 5 4.6 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
CHEMBL3351018 115470 None 0 Mouse Binding pKi = 8.4 8.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 576 12 5 5 4.6 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
5311201 207393 None 35 Mouse Binding pKi = 8.4 8.4 -26 6
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a001
CHEMBL9387 207393 None 35 Mouse Binding pKi = 8.4 8.4 -26 6
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm00048a001
CHEMBL408330 212703 None 0 Human Binding pKi = 8.4 8.4 -1 3
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](CCCC)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
44345946 14771 None 0 Human Binding pKi = 8.4 8.4 - 1
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 636 10 3 5 6.3 O=C(O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
CHEMBL120657 14771 None 0 Human Binding pKi = 8.4 8.4 - 1
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 636 10 3 5 6.3 O=C(O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
10722460 15190 None 0 Human Binding pKi = 8.4 8.4 309 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL121028 15190 None 0 Human Binding pKi = 8.4 8.4 309 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 612 5 2 3 6.9 O=C(Nc1cccc(Br)c1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
10532528 14548 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 676 19 6 7 1.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)=O 10.1021/jm0000416
CHEMBL120335 14548 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 676 19 6 7 1.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)=O 10.1021/jm0000416
10370877 115473 None 0 Mouse Binding pKi = 8.4 8.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 574 11 5 5 4.4 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00087a011
CHEMBL3351021 115473 None 0 Mouse Binding pKi = 8.4 8.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 574 11 5 5 4.4 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1 10.1021/jm00087a011
16733051 136954 None 0 Human Binding pKi = 8.4 8.4 758 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 595 8 2 7 4.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL374390 136954 None 0 Human Binding pKi = 8.4 8.4 758 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 595 8 2 7 4.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)NS(C)(=O)=O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44331468 4285 None 0 Human Binding pKi = 8.4 8.4 16 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 470 7 2 3 4.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100685 4285 None 0 Human Binding pKi = 8.4 8.4 16 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 470 7 2 3 4.8 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc21 10.1016/S0960-894X(96)00544-6
10580503 101688 None 0 Mouse Binding pKi = 8.4 8.4 234 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 691 11 6 10 3.7 O=C(NCC1CCCCCC1)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1F)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
CHEMBL299387 101688 None 0 Mouse Binding pKi = 8.4 8.4 234 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 691 11 6 10 3.7 O=C(NCC1CCCCCC1)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1F)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
44580898 188360 None 0 Human Binding pKi = 8.4 8.4 -5 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL501238 188360 None 0 Human Binding pKi = 8.4 8.4 -5 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
145991328 166905 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4286411 166905 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1086 34 13 11 0.1 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC[Se]C)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
14802520 120358 None 1 Mouse Binding pKi = 8.4 8.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL353157 120358 None 1 Mouse Binding pKi = 8.4 8.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 628 13 5 5 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CNC(=O)CCC(=O)O)Cc1ccccc1 10.1021/jm00087a011
44356448 168237 None 0 Mouse Binding pKi = 8.4 8.4 75 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2cccc(F)c2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL433656 168237 None 0 Mouse Binding pKi = 8.4 8.4 75 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 769 11 5 5 6.7 O=C(O)c1cc(NC(=O)[C@@H](Cc2cccc(F)c2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
5311201 207393 None 35 Mouse Binding pKi = 8.4 8.4 -26 6
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000960w
CHEMBL9387 207393 None 35 Mouse Binding pKi = 8.4 8.4 -26 6
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm000960w
118727699 117590 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 3179 132 21 45 9.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COCCOCCOCCOCCOCCCCc1cn(CCCCCCOc2cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
CHEMBL3400297 117590 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL 3179 132 21 45 9.8 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)COCCOCCOCCOCCOCCCCc1cn(CCCCCCOc2cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)cc(OCCCCCCn3cc(CCCCOCCOCCOCCOCCOCC(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O)nn3)c2)nn1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
44351445 116932 None 0 Human Binding pKi = 7.5 7.5 1 2
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 116932 None 0 Human Binding pKi = 7.5 7.5 1 2
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL3351049 211531 None 0 Human Binding pKi = 5.5 5.5 2 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
44271859 141523 None 0 Human Binding pKi = 6.5 6.5 4 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1292 39 14 16 2.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL384618 141523 None 0 Human Binding pKi = 6.5 6.5 4 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1292 39 14 16 2.0 CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
44344616 113809 None 0 Mouse Binding pKi = 5.5 5.5 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 583 6 1 5 3.9 O=C(O)CN1CC(=O)N2[C@@H](CC(=O)c3ccccc3N(Cc3ccccc3)C(=O)[C@H]2CC23CC4CC(CC(C4)C2)C3)C1=O 10.1021/jm000960w
CHEMBL332489 113809 None 0 Mouse Binding pKi = 5.5 5.5 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 583 6 1 5 3.9 O=C(O)CN1CC(=O)N2[C@@H](CC(=O)c3ccccc3N(Cc3ccccc3)C(=O)[C@H]2CC23CC4CC(CC(C4)C2)C3)C1=O 10.1021/jm000960w
118719254 115472 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351020 115472 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
10413618 202789 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL62205 202789 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
11363465 81552 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 472 6 1 6 4.4 CN(Cc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL216124 81552 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 472 6 1 6 4.4 CN(Cc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
11259485 81589 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 CC1CCCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
CHEMBL216320 81589 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 CC1CCCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1021/jm060590x
11352971 81905 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL216483 81905 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
16090694 82352 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 530 4 1 7 2.6 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL217225 82352 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 530 4 1 7 2.6 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
11352971 81905 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1016/j.bmc.2008.01.059
CHEMBL216483 81905 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 524 4 1 6 2.5 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1016/j.bmc.2008.01.059
44404005 12283 None 0 Mouse Binding pKi = 7.5 7.5 100 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 623 11 5 5 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184845 12283 None 0 Mouse Binding pKi = 7.5 7.5 100 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 623 11 5 5 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067963 12283 None 0 Mouse Binding pKi = 7.5 7.5 100 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 623 11 5 5 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2ccccc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
57392083 68402 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 735 23 7 8 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN=[N+]=[N-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2011.08.053
CHEMBL1917058 68402 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence methodDisplacement of Eu-DTAP-CCK8-NH2 from CCK2 receptor expressed in human HEK293 cells after 1 hr by time resolved fluorescence method
ChEMBL 735 23 7 8 2.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCN=[N+]=[N-])C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2011.08.053
CHEMBL440259 213860 None 0 Human Binding pKi = 6.5 6.5 4 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11612498 133560 None 0 Mouse Binding pKi = 6.5 6.5 -1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL371068 133560 None 0 Mouse Binding pKi = 6.5 6.5 -1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 469 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
45486997 197781 None 0 Human Binding pKi = 6.5 6.5 12 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 7 1 6 4.5 CN(CCc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL571832 197781 None 0 Human Binding pKi = 6.5 6.5 12 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 486 7 1 6 4.5 CN(CCc1ccccc1)C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
16090688 80340 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 444 5 1 6 4.2 CC(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL214283 80340 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 444 5 1 6 4.2 CC(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
11305046 82391 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 4 1 6 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL217255 82391 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 4 1 6 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
11212985 82441 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 445 5 1 7 3.2 CN(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL217514 82441 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 445 5 1 7 3.2 CN(C)c1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
11154873 141983 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 438 4 1 7 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL387413 141983 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 438 4 1 7 2.6 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
25033306 94483 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 552 6 1 7 5.1 CSc1nccc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)n1 10.1016/j.bmcl.2007.09.087
CHEMBL251485 94483 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 552 6 1 7 5.1 CSc1nccc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)n1 10.1016/j.bmcl.2007.09.087
25033305 154734 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 478 4 1 4 5.1 O=C(c1ccc(Br)cc1NS(=O)(=O)c1csc2ccccc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL399919 154734 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 478 4 1 4 5.1 O=C(c1ccc(Br)cc1NS(=O)(=O)c1csc2ccccc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033149 158840 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2ncsc2c1)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL409479 158840 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2ncsc2c1)N1CCCCC1 10.1016/j.bmc.2008.01.059
9844256 11795 None 0 Mouse Binding pKi = 5.5 5.5 3 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 406 7 3 2 4.6 O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 10.1021/jm049069y
CHEMBL1181869 11795 None 0 Mouse Binding pKi = 5.5 5.5 3 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 406 7 3 2 4.6 O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 10.1021/jm049069y
CHEMBL2067947 11795 None 0 Mouse Binding pKi = 5.5 5.5 3 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 406 7 3 2 4.6 O=C(O)CCNC(=O)c1cc(-c2ccccc2)[nH]c1CC12CC3CC(CC(C3)C1)C2 10.1021/jm049069y
10532660 113276 None 0 Human Binding pKi = 6.5 6.5 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
CHEMBL331495 113276 None 0 Human Binding pKi = 6.5 6.5 - 1
Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2Compound was tested for binding affinity against Cholecystokinin type B receptor on guinea pig cortex in experiment 2
ChEMBL 690 19 7 7 1.0 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)/C=C\C(=O)O 10.1021/jm0000416
44351524 19335 None 0 Human Binding pKi = 7.5 7.5 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 7 3 5 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL129070 19335 None 0 Human Binding pKi = 7.5 7.5 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 604 7 3 5 5.5 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10651635 165270 None 0 Rat Binding pKi = 7.5 7.5 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL423119 165270 None 0 Rat Binding pKi = 7.5 7.5 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 630 9 3 7 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44351446 156139 None 0 Rat Binding pKi = 7.5 7.5 -3 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 156139 None 0 Rat Binding pKi = 7.5 7.5 -3 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10004216 4741 None 0 Human Binding pKi = 6.5 6.5 11 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00528-2
CHEMBL103750 4741 None 0 Human Binding pKi = 6.5 6.5 11 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1016/0960-894X(95)00528-2
11505870 72505 None 0 Mouse Binding pKi = 6.5 6.5 2 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
CHEMBL199032 72505 None 0 Mouse Binding pKi = 6.5 6.5 2 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 526 8 3 4 6.6 Cc1ccccc1-c1nc(CCC23CC4CC(CC(C4)C2)C3)c(C(=O)Nc2ccc(N(C)C)c(C(=O)O)c2)[nH]1 10.1021/jm0490686
44351444 116884 None 0 Human Binding pKi = 6.5 6.5 -1 2
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 116884 None 0 Human Binding pKi = 6.5 6.5 -1 2
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
44580899 189073 None 0 Human Binding pKi = 7.5 7.5 -4 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 189073 None 0 Human Binding pKi = 7.5 7.5 -4 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
44331467 107451 None 0 Human Binding pKi = 7.5 7.5 41 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 529 7 1 4 5.8 CC(C)CCN1C(=O)C(NC(=O)Oc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL318291 107451 None 0 Human Binding pKi = 7.5 7.5 41 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 529 7 1 4 5.8 CC(C)CCN1C(=O)C(NC(=O)Oc2ccccc2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
10506830 113965 None 0 Human Binding pKi = 7.5 7.5 6 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 6 2 3 6.5 O=C(Nc1ccccc1)NC1C(=O)N(CCC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL332601 113965 None 0 Human Binding pKi = 7.5 7.5 6 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 548 6 2 3 6.5 O=C(Nc1ccccc1)NC1C(=O)N(CCC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
11801462 117464 None 0 Human Binding pKi = 6.5 6.5 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL339907 117464 None 0 Human Binding pKi = 6.5 6.5 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
16732598 85438 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 476 7 2 5 4.1 CC(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226571 85438 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 476 7 2 5 4.1 CC(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
15513861 12475 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 588 7 1 5 5.2 CC(=O)N1[C@H](C(=O)CC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118630 12475 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 588 7 1 5 5.2 CC(=O)N1[C@H](C(=O)CC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL386304 212378 None 0 Human Binding pKi = 6.5 6.5 6 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11802782 14558 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 7 7 1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C(=O)O 10.1021/jm0000416
CHEMBL120401 14558 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 692 19 7 7 1.1 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)C(=O)O 10.1021/jm0000416
11798204 194591 None 0 Mouse Binding pKi = 6.5 6.5 10 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 460 5 2 3 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2ccccc2cc1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
CHEMBL53129 194591 None 0 Mouse Binding pKi = 6.5 6.5 10 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 460 5 2 3 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2ccccc2cc1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
44331343 4409 None 0 Human Binding pKi = 7.5 7.5 57 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 606 6 2 3 7.0 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O 10.1016/S0960-894X(96)00544-6
CHEMBL101456 4409 None 0 Human Binding pKi = 7.5 7.5 57 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 606 6 2 3 7.0 O=C(Nc1ccccc1)NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(CC23CC4CC(CC(C4)C2)C3)C1=O 10.1016/S0960-894X(96)00544-6
44280114 5108 None 0 Rat Binding pKi = 5.5 5.5 -1 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/s0960-894x(98)00231-5
CHEMBL105618 5108 None 0 Rat Binding pKi = 5.5 5.5 -1 2
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 567 7 2 4 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CCC(C(=O)c2ccccc2)CC1 10.1016/s0960-894x(98)00231-5
14208194 163434 None 2 Rat Binding pKi = 6.5 6.5 -1122 2
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9703247
CHEMBL419764 163434 None 2 Rat Binding pKi = 6.5 6.5 -1122 2
Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranesInhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm9703247
10255015 208301 None 0 Human Binding pKi = 5.5 5.5 -4 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 490 8 4 2 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL99065 208301 None 0 Human Binding pKi = 5.5 5.5 -4 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 490 8 4 2 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1021/jm00072a005
70693901 73957 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)NC(CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
CHEMBL2021373 73957 None 0 Mouse Binding pKi = 6.5 6.5 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)NC(CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
44580898 188360 None 0 Human Binding pKi = 6.5 6.5 -5 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL501238 188360 None 0 Human Binding pKi = 6.5 6.5 -5 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
90662935 106573 None 0 Rat Binding pKi = 7.4 7.4 -10 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1057 30 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3142373 106573 None 0 Rat Binding pKi = 7.4 7.4 -10 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 1057 30 11 11 2.6 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)/C=C/c1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL3351062 211541 None 0 Human Binding pKi = 7.4 7.4 173 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
9808153 112672 None 0 Human Binding pKi = 7.4 7.4 36 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 4 5.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1021/jm00072a005
CHEMBL330390 112672 None 0 Human Binding pKi = 7.4 7.4 36 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 571 11 3 4 5.6 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCC(=O)O)CCc1ccccc1 10.1021/jm00072a005
10054705 108425 None 0 Human Binding pKi = 7.4 7.4 28 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 625 10 3 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
CHEMBL319880 108425 None 0 Human Binding pKi = 7.4 7.4 28 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 625 10 3 4 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1Cl)CC(=O)O 10.1021/jm00072a005
11216391 163491 None 0 Rat Binding pKi = 5.4 5.4 -1348 2
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL 747 23 7 7 2.1 CCCCCNC(=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
CHEMBL420161 163491 None 0 Rat Binding pKi = 5.4 5.4 -1348 2
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL 747 23 7 7 2.1 CCCCCNC(=O)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
15513859 113808 None 0 Mouse Binding pKi = 6.4 6.4 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 680 8 2 7 3.3 CC(=O)N1[C@H](C(=O)NCC(=O)NS(C)(=O)=O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL332488 113808 None 0 Mouse Binding pKi = 6.4 6.4 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 680 8 2 7 3.3 CC(=O)N1[C@H](C(=O)NCC(=O)NS(C)(=O)=O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
44451523 95941 None 0 Human Binding pKi = 6.4 6.4 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
CHEMBL259390 95941 None 0 Human Binding pKi = 6.4 6.4 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 541 7 2 5 4.1 O=C(CN1C(=O)N(CC(=O)N2CCCC2)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(C(=O)O)c1 10.1016/j.bmc.2007.12.047
44408524 155703 None 0 Human Binding pKi = 5.4 5.4 -158 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL405192 155703 None 0 Human Binding pKi = 5.4 5.4 -158 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1134 30 12 15 2.6 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)C(=O)O 10.1021/jm050851n
11512746 70608 None 0 Mouse Binding pKi = 5.4 5.4 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 405 6 3 3 5.3 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)(C)C)[nH]1 10.1021/jm0490686
CHEMBL194974 70608 None 0 Mouse Binding pKi = 5.4 5.4 - 1
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 405 6 3 3 5.3 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)(C)C)[nH]1 10.1021/jm0490686
118719285 115481 None 0 Human Binding pKi = 7.4 7.4 1 3
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
CHEMBL3351057 115481 None 0 Human Binding pKi = 7.4 7.4 1 3
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
10482233 168200 None 0 Human Binding pKi = 7.4 7.4 41 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 533 8 3 3 6.0 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1 10.1021/jm00072a005
CHEMBL433407 168200 None 0 Human Binding pKi = 7.4 7.4 41 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 533 8 3 3 6.0 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Cl)cc1 10.1021/jm00072a005
10440219 168696 None 0 Human Binding pKi = 7.4 7.4 25 2
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 776 15 6 7 4.4 CN(C)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)c1ccccc1 10.1016/S0960-894X(00)80678-2
CHEMBL436722 168696 None 0 Human Binding pKi = 7.4 7.4 25 2
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL 776 15 6 7 4.4 CN(C)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)c1ccccc1 10.1016/S0960-894X(00)80678-2
11518283 166158 None 0 Mouse Binding pKi = 7.4 7.4 -5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL426290 166158 None 0 Mouse Binding pKi = 7.4 7.4 -5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 461 7 3 3 6.2 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CCCC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
45486955 197396 None 0 Human Binding pKi = 7.4 7.4 5 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 628 8 3 7 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569470 197396 None 0 Human Binding pKi = 7.4 7.4 5 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 628 8 3 7 5.0 O=C(N[C@@H](Cc1ccc(Cl)c(Br)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
16090781 141962 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 498 4 1 6 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)ccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL387287 141962 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 498 4 1 6 4.0 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)ccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11453391 168838 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL437908 168838 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11453391 168838 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL437908 168838 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
118719084 120601 None 0 Mouse Binding pKi = 6.4 6.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3350691 120601 None 0 Mouse Binding pKi = 6.4 6.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3545975 120601 None 0 Mouse Binding pKi = 6.4 6.4 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 602 12 5 5 4.9 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1)C2 10.1021/jm00087a011
45486933 196934 None 1 Human Binding pKi = 6.4 6.4 -3 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 520 7 2 6 5.3 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
CHEMBL566360 196934 None 1 Human Binding pKi = 6.4 6.4 -3 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 520 7 2 6 5.3 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
1098327 141961 None 5 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL387285 141961 None 5 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1016/j.bmcl.2007.09.087
1098327 141961 None 5 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL387285 141961 None 5 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 436 4 1 6 3.8 O=C(c1cc(Cl)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
44403999 12282 None 0 Mouse Binding pKi = 6.4 6.4 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 619 10 5 5 5.2 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm049069y
CHEMBL1184841 12282 None 0 Mouse Binding pKi = 6.4 6.4 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 619 10 5 5 5.2 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm049069y
CHEMBL2067962 12282 None 0 Mouse Binding pKi = 6.4 6.4 12 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 619 10 5 5 5.2 O=C(O)c1cccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm049069y
25033307 94518 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 525 5 1 6 5.4 Cc1nc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)cs1 10.1016/j.bmcl.2007.09.087
CHEMBL251655 94518 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 525 5 1 6 5.4 Cc1nc(-c2ccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)s2)cs1 10.1016/j.bmcl.2007.09.087
16090652 141560 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 416 4 1 6 2.0 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL384854 141560 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 416 4 1 6 2.0 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
16090693 141683 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 7 2.1 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL385552 141683 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 422 4 1 7 2.1 O=C(c1ccc(F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCOCC1 10.1021/jm060590x
9956948 11926 None 0 Mouse Binding pKi = 5.4 5.4 -1 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 483 7 4 4 6.0 O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 10.1021/jm049069y
CHEMBL1182723 11926 None 0 Mouse Binding pKi = 5.4 5.4 -1 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 483 7 4 4 6.0 O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 10.1021/jm049069y
CHEMBL2067953 11926 None 0 Mouse Binding pKi = 5.4 5.4 -1 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 483 7 4 4 6.0 O=C(Nc1cc(CO)cc(CO)c1)c1[nH]c(-c2ccc3ccccc3c2)nc1CC1CCCCCC1 10.1021/jm049069y
10605398 114494 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
CHEMBL333516 114494 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 807 21 8 9 1.8 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)O 10.1021/jm0000416
16733645 13179 None 0 Human Binding pKi = 8.4 8.4 416 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 598 9 2 7 5.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1190962 13179 None 0 Human Binding pKi = 8.4 8.4 416 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 598 9 2 7 5.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL541903 13179 None 0 Human Binding pKi = 8.4 8.4 416 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 598 9 2 7 5.4 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-c3cn(CC(=O)O)cn3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10604847 194675 None 0 Mouse Binding pKi = 8.4 8.4 218 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 711 11 6 10 3.8 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
CHEMBL53237 194675 None 0 Mouse Binding pKi = 8.4 8.4 218 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 711 11 6 10 3.8 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 10.1021/jm9508907
10004216 4741 None 0 Human Binding pKi = 8.4 8.4 11 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL103750 4741 None 0 Human Binding pKi = 8.4 8.4 11 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 456 6 2 3 4.9 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
44451547 96710 None 0 Human Binding pKi = 8.4 8.4 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
CHEMBL264150 96710 None 0 Human Binding pKi = 8.4 8.4 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 8 2 8 4.7 CN(c1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1)c1nn[nH]n1 10.1016/j.bmc.2007.12.047
16733057 136952 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 9 2 7 4.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(S(=O)(=O)CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL374389 136952 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 9 2 7 4.3 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(S(=O)(=O)CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10628607 116772 None 0 Mouse Binding pKi = 8.4 8.4 467 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 713 11 5 5 6.4 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL337673 116772 None 0 Mouse Binding pKi = 8.4 8.4 467 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 713 11 5 5 6.4 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm00021a019
10842269 101572 None 0 Mouse Binding pKi = 8.4 8.4 575 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 681 11 6 6 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL298551 101572 None 0 Mouse Binding pKi = 8.4 8.4 575 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 681 11 6 6 5.0 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
16733182 98565 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 556 8 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(Cc3nnn[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL276645 98565 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 556 8 2 7 4.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(Cc3nnn[nH]3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10697783 117631 None 0 Human Binding pKi = 8.3 8.3 141 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1ccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)cc1 10.1021/jm990967h
CHEMBL340107 117631 None 0 Human Binding pKi = 8.3 8.3 141 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 543 7 2 4 5.7 CN(C)c1ccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)cc1 10.1021/jm990967h
44272076 168807 None 0 Human Binding pKi = 8.3 8.3 407 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL437661 168807 None 0 Human Binding pKi = 8.3 8.3 407 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)[C@H](NC(=O)OC(C)(C)C)CCC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16732443 85495 None 0 Human Binding pKi = 8.3 8.3 1202 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 7 2 5 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227147 85495 None 0 Human Binding pKi = 8.3 8.3 1202 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 532 7 2 5 5.6 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL331517 211376 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)CC(=O)O 10.1021/jm0000416
CHEMBL336381 211581 None 0 Human Binding pKi = 8.3 8.3 97 5
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in HEK293 cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm050921q
10101023 89455 None 0 Human Binding pKi = 7.4 7.4 57 2
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 675 11 8 7 -0.1 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371224 89455 None 0 Human Binding pKi = 7.4 7.4 57 2
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 675 11 8 7 -0.1 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CC(=O)NCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
10482868 107402 None 0 Rat Binding pKi = 7.4 7.4 -2 5
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL317999 107402 None 0 Rat Binding pKi = 7.4 7.4 -2 5
Tested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in rat cortex by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
44346825 114771 None 0 Mouse Binding pKi = 7.4 7.4 77 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
CHEMBL333920 114771 None 0 Mouse Binding pKi = 7.4 7.4 77 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
10006936 207723 None 0 Human Binding pKi = 6.4 6.4 5 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 521 6 3 3 6.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccc2ccccc2c1 10.1021/jm00072a005
CHEMBL95689 207723 None 0 Human Binding pKi = 6.4 6.4 5 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 521 6 3 3 6.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccc2ccccc2c1 10.1021/jm00072a005
10367509 107440 None 0 Human Binding pKi = 6.4 6.4 14 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 471 6 3 3 5.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccccc1 10.1021/jm00072a005
CHEMBL318238 107440 None 0 Human Binding pKi = 6.4 6.4 14 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 471 6 3 3 5.7 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)Nc1ccccc1 10.1021/jm00072a005
44344932 12416 None 0 Mouse Binding pKi = 6.4 6.4 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(F)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118584 12416 None 0 Mouse Binding pKi = 6.4 6.4 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1C(C(=O)NCC(=O)O)CC(=O)c2cc(F)ccc2N(Cc2ccccc2)C(=O)C1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL64605 215854 None 7 Human Binding pKi = 7.4 7.4 -4 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
44331483 107496 None 0 Human Binding pKi = 7.4 7.4 25 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 541 5 1 4 6.1 O=C(NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O)Oc1ccccc1 10.1016/S0960-894X(96)00544-6
CHEMBL318569 107496 None 0 Human Binding pKi = 7.4 7.4 25 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 541 5 1 4 6.1 O=C(NC1C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc2N(C2CCCCC2)C1=O)Oc1ccccc1 10.1016/S0960-894X(96)00544-6
CHEMBL3350278 211464 None 0 Human Binding pKi = 5.4 5.4 -20 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
11800431 11022 None 0 Mouse Binding pKi = 5.4 5.4 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 533 7 2 5 3.6 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCC1 10.1021/jm000960w
CHEMBL117510 11022 None 0 Mouse Binding pKi = 5.4 5.4 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 533 7 2 5 3.6 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC1CCCCC1 10.1021/jm000960w
11804040 119446 None 0 Rat Binding pKi = 6.4 6.4 -2137 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL345049 119446 None 0 Rat Binding pKi = 6.4 6.4 -2137 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 976 28 9 11 1.6 CCCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL3142843 211134 None 0 Human Binding pKi = 5.4 5.4 6 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)NCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
10508568 89454 None 0 Human Binding pKi = 5.4 5.4 - 1
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371223 89454 None 0 Human Binding pKi = 5.4 5.4 - 1
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 660 11 7 6 2.0 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
11592162 76527 None 0 Human Binding pKi = 7.4 7.4 2 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206079 76527 None 0 Human Binding pKi = 7.4 7.4 2 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 561 11 2 6 5.9 CCOCCNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
44351454 116816 None 0 Human Binding pKi = 7.4 7.4 1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337933 116816 None 0 Human Binding pKi = 7.4 7.4 1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
11561828 140625 None 0 Mouse Binding pKi = 6.4 6.4 4 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 2 6.8 O=C(O)c1cccc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL381426 140625 None 0 Mouse Binding pKi = 6.4 6.4 4 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 468 7 3 2 6.8 O=C(O)c1cccc(NC(=O)c2cc(-c3ccccc3)[nH]c2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44351445 116932 None 0 Human Binding pKi = 7.3 7.3 1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338525 116932 None 0 Human Binding pKi = 7.3 7.3 1 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 654 8 3 6 5.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1021/jm970439a
10323690 99301 None 0 Mouse Binding pKi = 7.3 7.3 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
CHEMBL282056 99301 None 0 Mouse Binding pKi = 7.3 7.3 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 10.1021/jm00087a011
11511706 72259 None 0 Mouse Binding pKi = 7.3 7.3 1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL198225 72259 None 0 Mouse Binding pKi = 7.3 7.3 1 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 501 7 3 3 6.6 Cc1ccccc1-c1nc(C(=O)Nc2ccc(F)c(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
44344987 113806 None 0 Mouse Binding pKi = 7.3 7.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 7 2 5 5.2 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL332482 113806 None 0 Mouse Binding pKi = 7.3 7.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 633 7 2 5 5.2 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10557073 16370 None 0 Human Binding pKi = 5.3 5.3 -3467 2
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 763 20 7 8 2.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C 10.1021/jm0000416
CHEMBL122934 16370 None 0 Human Binding pKi = 5.3 5.3 -3467 2
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 763 20 7 8 2.3 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C 10.1021/jm0000416
15297880 114538 None 0 Mouse Binding pKi = 5.3 5.3 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1ccc2ccccc2c1 10.1021/jm00048a001
CHEMBL333664 114538 None 0 Mouse Binding pKi = 5.3 5.3 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 433 4 2 2 5.1 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCc1ccc2ccccc2c1 10.1021/jm00048a001
44272056 98162 None 0 Human Binding pKi = 7.3 7.3 42 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL273880 98162 None 0 Human Binding pKi = 7.3 7.3 42 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1194 24 13 13 2.6 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
16731871 166332 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 492 9 2 5 4.6 CCOCCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL427277 166332 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 492 9 2 5 4.6 CCOCCN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10601706 14148 None 0 Mouse Binding pKi = 5.3 5.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 507 6 2 5 3.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC(C)(C)C 10.1021/jm000960w
CHEMBL119825 14148 None 0 Mouse Binding pKi = 5.3 5.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 507 6 2 5 3.0 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC(C)(C)C 10.1021/jm000960w
45486985 197751 None 0 Human Binding pKi = 8.3 8.3 63 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 650 8 3 6 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL571650 197751 None 0 Human Binding pKi = 8.3 8.3 63 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 650 8 3 6 4.5 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
11700410 198753 None 0 Human Binding pKi = 8.3 8.3 31 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 704 8 3 7 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL583035 198753 None 0 Human Binding pKi = 8.3 8.3 31 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 704 8 3 7 4.4 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
11353036 141419 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 528 4 1 6 3.7 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL384097 141419 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 528 4 1 6 3.7 O=C(c1ccc(I)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
10770670 92491 None 0 Mouse Binding pKi = 8.3 8.3 301 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067959 92491 None 0 Mouse Binding pKi = 8.3 8.3 301 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL24313 92491 None 0 Mouse Binding pKi = 8.3 8.3 301 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL3351054 211536 None 0 Human Binding pKi = 8.3 8.3 812 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccc2ccccc2c1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
11527738 75987 None 0 Human Binding pKi = 8.3 8.3 -2 4
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL205455 75987 None 0 Human Binding pKi = 8.3 8.3 -2 4
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
11527738 75987 None 0 Human Binding pKi = 8.3 8.3 -2 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL205455 75987 None 0 Human Binding pKi = 8.3 8.3 -2 4
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 7 2 5 5.2 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44346097 168142 None 0 Human Binding pKi = 8.3 8.3 - 1
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 664 11 2 6 6.8 CCOC(=O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
CHEMBL433028 168142 None 0 Human Binding pKi = 8.3 8.3 - 1
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 664 11 2 6 6.8 CCOC(=O)CCCOc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)cc1 10.1021/jm990967h
10770670 92491 None 0 Mouse Binding pKi = 8.3 8.3 301 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL2067959 92491 None 0 Mouse Binding pKi = 8.3 8.3 301 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL24313 92491 None 0 Mouse Binding pKi = 8.3 8.3 301 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 6 6 4.9 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
10484529 101431 None 0 Mouse Binding pKi = 8.3 8.3 707 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 5 6 5.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccoc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL297480 101431 None 0 Mouse Binding pKi = 8.3 8.3 707 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 663 11 5 6 5.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)c2cc3ccoc3cc2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm9508907
11591504 75052 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 1 5 5.5 COc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL203530 75052 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 504 7 1 5 5.5 COc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16732018 85466 None 0 Human Binding pKi = 8.3 8.3 741 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 548 9 2 6 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(OCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL226729 85466 None 0 Human Binding pKi = 8.3 8.3 741 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 548 9 2 6 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(OCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
16732916 136951 None 0 Human Binding pKi = 8.3 8.3 338 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 8 2 5 6.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C23CC4CC(CC(C4)C2)C3)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
CHEMBL374388 136951 None 0 Human Binding pKi = 8.3 8.3 338 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 596 8 2 5 6.3 O=C(CN1N=C(C2CCCCC2)c2ccccc2N(CC(=O)C23CC4CC(CC(C4)C2)C3)C1=O)Nc1cccc(C(=O)O)c1 10.1021/jm070139l
21476261 4293 None 0 Human Binding pKi = 8.3 8.3 169 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 571 8 2 4 5.9 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100776 4293 None 0 Human Binding pKi = 8.3 8.3 169 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 571 8 2 4 5.9 CC(C)CCN1C(=O)C(NC(=O)Nc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
11605694 168651 None 0 Mouse Binding pKi = 8.2 8.2 5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
CHEMBL436314 168651 None 0 Mouse Binding pKi = 8.2 8.2 5 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(NC(=O)c2[nH]c(-c3ccccc3C)nc2CCC23CC4CC(CC(C4)C2)C3)cc1C(=O)O 10.1021/jm0490686
10031454 108586 None 0 Human Binding pKi = 7.3 7.3 67 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 596 10 2 4 5.5 CC(Cc1ccc(Br)cc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL320399 108586 None 0 Human Binding pKi = 7.3 7.3 67 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 596 10 2 4 5.5 CC(Cc1ccc(Br)cc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
11534407 196933 None 0 Human Binding pKi = 6.3 6.3 -6 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL566359 196933 None 0 Human Binding pKi = 6.3 6.3 -6 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 584 8 3 7 4.9 O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11541048 196973 None 0 Human Binding pKi = 6.3 6.3 -7 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
CHEMBL566604 196973 None 0 Human Binding pKi = 6.3 6.3 -7 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 C[C@H](CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
11635377 198807 None 0 Human Binding pKi = 6.3 6.3 -39 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 554 7 2 6 6.0 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2009.09.064
CHEMBL583457 198807 None 0 Human Binding pKi = 6.3 6.3 -39 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 554 7 2 6 6.0 CC(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2009.09.064
25033380 94156 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 498 5 1 6 3.9 COC(=O)c1c(C)oc(C)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL249469 94156 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 498 5 1 6 3.9 COC(=O)c1c(C)oc(C)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
24755148 94481 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 458 4 1 3 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)cccc1F)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251466 94481 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 458 4 1 3 4.2 O=C(c1ccc(Br)cc1NS(=O)(=O)c1c(F)cccc1F)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090646 82488 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 1 7 3.8 COc1cc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)cc1Cl 10.1021/jm060590x
CHEMBL217715 82488 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 466 5 1 7 3.8 COc1cc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)cc1Cl 10.1021/jm060590x
11202178 141835 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 467 5 1 7 3.9 O=C(c1ccc(-n2cccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL386438 141835 None 0 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 467 5 1 7 3.9 O=C(c1ccc(-n2cccc2)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
44451830 157933 None 1 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 536 6 2 6 4.8 O=C(NCc1ccc(Cl)cc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmc.2008.01.059
CHEMBL408452 157933 None 1 Human Binding pKi = 6.3 6.3 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 536 6 2 6 4.8 O=C(NCc1ccc(Cl)cc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmc.2008.01.059
44403982 12276 None 0 Mouse Binding pKi = 6.3 6.3 7 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 4.9 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184798 12276 None 0 Mouse Binding pKi = 6.3 6.3 7 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 4.9 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067958 12276 None 0 Mouse Binding pKi = 6.3 6.3 7 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 677 11 5 6 4.9 CN(C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2[nH]cnc2cc1C(=O)NCC12CC3CC(CC(C3)C1)C2)c1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm049069y
25033309 94516 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 447 4 1 4 3.7 N#Cc1cccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1 10.1016/j.bmcl.2007.09.087
CHEMBL251652 94516 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 447 4 1 4 3.7 N#Cc1cccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1 10.1016/j.bmcl.2007.09.087
16090782 141964 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2nsnc2c1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL387299 141964 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 480 4 1 6 3.9 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc2nsnc2c1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033226 154764 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 484 5 1 6 3.6 COC(=O)c1cc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)oc1C 10.1016/j.bmcl.2007.09.087
CHEMBL400114 154764 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 484 5 1 6 3.6 COC(=O)c1cc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)oc1C 10.1016/j.bmcl.2007.09.087
24983506 154780 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 516 6 1 7 3.7 COC(=O)c1csc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1OC 10.1016/j.bmcl.2007.09.087
CHEMBL400164 154780 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 516 6 1 7 3.7 COC(=O)c1csc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)c1OC 10.1016/j.bmcl.2007.09.087
25033310 154781 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 563 5 1 6 5.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)on2)s1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL400165 154781 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 563 5 1 6 5.6 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)on2)s1)N1CCCCC1 10.1016/j.bmcl.2007.09.087
16090695 141493 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL384457 141493 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
16090699 141914 None 0 Human Binding pKi = 5.3 5.3 -1 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 463 8 4 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
CHEMBL386985 141914 None 0 Human Binding pKi = 5.3 5.3 -1 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 463 8 4 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccccc1NS(=O)(=O)c1cc2ccccc2[nH]1 10.1021/jm060590x
25033065 160140 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 493 4 1 5 4.8 Cc1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2s1 10.1016/j.bmc.2008.01.059
CHEMBL410905 160140 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 493 4 1 5 4.8 Cc1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2s1 10.1016/j.bmc.2008.01.059
118719285 115481 None 0 Rat Binding pKi = 7.3 7.3 -1 3
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
CHEMBL3351057 115481 None 0 Rat Binding pKi = 7.3 7.3 -1 3
Affinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membraneAffinity of compound on binding of [3H]pCCK-8 to the cholecystokinin type B receptor in rat brain membrane
ChEMBL 733 15 5 7 4.7 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)c1ccccc1 10.1021/jm00053a022
10439779 106684 None 0 Human Binding pKi = 7.3 7.3 1 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL3143501 106684 None 0 Human Binding pKi = 7.3 7.3 1 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
9985629 168057 None 0 Human Binding pKi = 7.3 7.3 41 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 577 8 3 3 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Br)cc1 10.1021/jm00072a005
CHEMBL432389 168057 None 0 Human Binding pKi = 7.3 7.3 41 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 577 8 3 3 6.1 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc(Br)cc1 10.1021/jm00072a005
CHEMBL353862 211726 None 0 Rat Binding pKi = 7.3 7.3 -1 3
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in rat brain membranesTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in rat brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O)c1ccccc1 10.1016/S0960-894X(00)80678-2
443375 207604 None 45 Human Binding pKi = 7.3 7.3 -316 5
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
CHEMBL9506 207604 None 45 Human Binding pKi = 7.3 7.3 -316 5
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm051219x
10698813 11640 None 0 Mouse Binding pKi = 6.3 6.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL118096 11640 None 0 Mouse Binding pKi = 6.3 6.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 7 2 5 4.6 CC(=O)N1[C@H](C(=O)N[C@H](C)C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10579209 110397 None 0 Mouse Binding pKi = 5.3 5.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@@H](CC23CC4CC(CC(C4)C2)C3)C(=O)N(Cc2ccccc2)c2ccccc2C(=O)C[C@@H]1C(=O)NCC(=O)O 10.1021/jm000960w
CHEMBL324367 110397 None 0 Mouse Binding pKi = 5.3 5.3 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 585 7 2 5 4.2 CC(=O)N1[C@@H](CC23CC4CC(CC(C4)C2)C3)C(=O)N(Cc2ccccc2)c2ccccc2C(=O)C[C@@H]1C(=O)NCC(=O)O 10.1021/jm000960w
9853654 22787 None 41 Human Binding pKi = 7.3 7.3 31 2
Inhibition of binding of [125I]-PD 142251 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142251 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
CHEMBL1328 22787 None 41 Human Binding pKi = 7.3 7.3 31 2
Inhibition of binding of [125I]-PD 142251 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142251 to CCK-B receptor was determined
ChEMBL 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/0960-894X(95)00435-V
44357208 118981 None 0 Mouse Binding pKi = 6.3 6.3 4 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 737 10 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342465 118981 None 0 Mouse Binding pKi = 6.3 6.3 4 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 737 10 5 5 6.7 O=C(O)c1cc(NC(=O)[C@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)c2ccccc2)cc(C(=O)O)c1 10.1021/jm00021a019
10075052 189672 None 0 Human Binding pKi = 6.3 6.3 -10 2
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515268 189672 None 0 Human Binding pKi = 6.3 6.3 -10 2
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
CHEMBL515288 189672 None 0 Human Binding pKi = 6.3 6.3 -10 2
Displacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometryDisplacement of [125I](R)-1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)urea from human CCK2 receptor expressed in CHO cells by gamma spectrometry
ChEMBL 510 3 2 3 4.3 CN1C(=O)[C@H](NC(=O)Nc2cccc(I)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm801439x
15249830 101933 None 0 Mouse Binding pKi = 6.3 6.3 15 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 441 4 2 2 4.9 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
CHEMBL301095 101933 None 0 Mouse Binding pKi = 6.3 6.3 15 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 441 4 2 2 4.9 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm9508907
44347142 114129 None 0 Mouse Binding pKi = 6.3 6.3 15 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 441 4 2 2 4.8 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL332873 114129 None 0 Mouse Binding pKi = 6.3 6.3 15 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 441 4 2 2 4.8 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3 10.1021/jm00048a001
CHEMBL3350720 211486 None 0 Human Binding pKi = 7.3 7.3 4 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O 10.1021/jm00174a016
CHEMBL216831 209341 None 0 Human Binding pKi = 7.3 7.3 29 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCC)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
44280576 163261 None 0 Rat Binding pKi = 6.3 6.3 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL418593 163261 None 0 Rat Binding pKi = 6.3 6.3 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10393515 108704 None 0 Human Binding pKi = 6.3 6.3 - 1
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 585 11 2 5 5.7 CCOC(=O)CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
CHEMBL320823 108704 None 0 Human Binding pKi = 6.3 6.3 - 1
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 585 11 2 5 5.7 CCOC(=O)CN(CCc1ccccc1)C(=O)C(C)(Cc1c[nH]c2ccccc12)NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2 10.1021/jm00072a005
44351415 168387 None 0 Human Binding pKi = 7.3 7.3 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2cccc(Cl)c2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL434631 168387 None 0 Human Binding pKi = 7.3 7.3 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 634 9 3 6 5.3 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](OCc2cccc(Cl)c2)C[C@@H]1C(=O)O 10.1021/jm970439a
44408632 158235 None 0 Human Binding pKi = 6.3 6.3 -2454 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL408832 158235 None 0 Human Binding pKi = 6.3 6.3 -2454 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC23CC4CC(CC(C4)C2)C3)c2ccccc12)C(=O)O 10.1021/jm050851n
44580898 188360 None 0 Human Binding pKi = 7.2 7.2 -5 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL501238 188360 None 0 Human Binding pKi = 7.2 7.2 -5 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 973 16 8 14 1.0 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
44356888 118867 None 0 Mouse Binding pKi = 7.2 7.2 35 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 765 12 5 5 7.0 O=C(O)c1cc(NC(=O)[C@@H](CCc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342205 118867 None 0 Mouse Binding pKi = 7.2 7.2 35 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 765 12 5 5 7.0 O=C(O)c1cc(NC(=O)[C@@H](CCc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL3350331 211471 None 0 Human Binding pKi = 6.2 6.2 -1 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
CHEMBL320868 211227 None 0 Rat Binding pKi = 6.2 6.2 -70 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
15513854 114805 None 0 Mouse Binding pKi = 6.2 6.2 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 635 7 2 6 5.1 COC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL334054 114805 None 0 Mouse Binding pKi = 6.2 6.2 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 635 7 2 6 5.1 COC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL3351048 211530 None 0 Human Binding pKi = 6.2 6.2 5 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
9984452 29712 None 0 Mouse Binding pKi = 8.2 8.2 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL138657 29712 None 0 Mouse Binding pKi = 8.2 8.2 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 529 9 4 4 4.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
11511721 76100 None 0 Human Binding pKi = 8.2 8.2 4 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205751 76100 None 0 Human Binding pKi = 8.2 8.2 4 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 502 7 2 5 5.5 CNc1cccc(NC(=O)C[C@@H]2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
11663565 76194 None 0 Human Binding pKi = 8.2 8.2 15 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL205831 76194 None 0 Human Binding pKi = 8.2 8.2 15 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 517 7 1 5 5.5 CN(C)c1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
16731537 85511 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2ccn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL227277 85511 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 571 8 2 6 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc3c2ccn3CC(=O)O)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44351469 116933 None 0 Human Binding pKi = 8.2 8.2 2 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338526 116933 None 0 Human Binding pKi = 8.2 8.2 2 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 603 7 3 4 6.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1CC(c2ccc(Cl)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL3400294 211627 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assayDisplacement of Eu-DTPA-PEGO-CCK4 from human cholecystokinin 2 receptor overexpressed in HEK-293 cells co-expressing human MC4R after 1 hr by time resolved fluorescence-based competition binding assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmc.2015.02.028
10257865 208436 None 4 Human Binding pKi = 8.2 8.2 2 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 208436 None 4 Human Binding pKi = 8.2 8.2 2 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
16733463 14000 None 0 Human Binding pKi = 8.2 8.2 1380 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 547 9 3 6 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL1197033 14000 None 0 Human Binding pKi = 8.2 8.2 1380 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 547 9 3 6 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL559157 14000 None 0 Human Binding pKi = 8.2 8.2 1380 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 547 9 3 6 5.0 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(NCC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
10623068 112839 None 0 Human Binding pKi = 8.2 8.2 89 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 442 6 2 3 4.7 CCCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL330854 112839 None 0 Human Binding pKi = 8.2 8.2 89 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 442 6 2 3 4.7 CCCCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21 10.1021/jm990967h
45486936 196969 None 0 Human Binding pKi = 8.2 8.2 25 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 640 8 3 6 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
CHEMBL566574 196969 None 0 Human Binding pKi = 8.2 8.2 25 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 640 8 3 6 5.1 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1cc(Cl)c(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1016/j.bmcl.2009.09.065
45486976 198970 None 0 Human Binding pKi = 8.2 8.2 39 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 656 8 3 7 4.6 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
CHEMBL585157 198970 None 0 Human Binding pKi = 8.2 8.2 39 2
Displacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from human CCK-2R after 100 mins by liquid scintillation counting
ChEMBL 656 8 3 7 4.6 O=C(N[C@@H](Cc1ccc(F)c(Br)c1)C(=O)O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.065
44451622 95914 None 0 Human Binding pKi = 8.2 8.2 4 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
CHEMBL259276 95914 None 0 Human Binding pKi = 8.2 8.2 4 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 562 9 2 5 5.5 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(CCC(=O)O)c2)C(=O)N(C2CCCCC2)c2ccccc21 10.1016/j.bmc.2007.12.047
44346355 157865 None 0 Human Binding pKi = 8.2 8.2 30 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL408389 157865 None 0 Human Binding pKi = 8.2 8.2 30 3
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 1260 26 13 15 1.7 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
CHEMBL2370588 209870 None 0 Human Binding pKi = 8.2 8.2 446 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
10257865 208436 None 4 Human Binding pKi = 8.2 8.2 2 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
CHEMBL99939 208436 None 4 Human Binding pKi = 8.2 8.2 2 5
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 591 10 3 4 5.8 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccc(Cl)cc1)CC(=O)O 10.1021/jm00072a005
44351444 116884 None 0 Human Binding pKi = 8.2 8.2 -1 2
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL338300 116884 None 0 Human Binding pKi = 8.2 8.2 -1 2
Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 622 8 3 6 4.8 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(F)cc2F)C[C@@H]1C(=O)O 10.1021/jm970439a
11643045 72136 None 0 Mouse Binding pKi = 8.2 8.2 43 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197873 72136 None 0 Mouse Binding pKi = 8.2 8.2 43 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 511 9 3 3 6.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(CCC(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
10793611 15497 None 0 Human Binding pKi = 7.2 7.2 4 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 7 2 4 7.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL121624 15497 None 0 Human Binding pKi = 7.2 7.2 4 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 594 7 2 4 7.2 CSc1cccc(NC(=O)NC2C(=O)N(CCC34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)c3ccccc3N(c3ccccc3)C2=O)c1 10.1021/jm990967h
CHEMBL1171596 208577 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2010.05.078
14802539 76550 None 1 Mouse Binding pKi = 7.2 7.2 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
CHEMBL2062144 76550 None 1 Mouse Binding pKi = 7.2 7.2 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 614 12 5 5 4.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NC[C@H](NC(=O)CCC(=O)O)c1ccccc1 10.1021/jm00087a011
11495719 70371 None 0 Mouse Binding pKi = 6.2 6.2 -30 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
CHEMBL194514 70371 None 0 Mouse Binding pKi = 6.2 6.2 -30 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 431 7 3 3 5.8 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC2CCCCC2)[nH]1 10.1021/jm0490686
73354642 89456 None 0 Human Binding pKi = 7.2 7.2 2 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL2371225 89456 None 0 Human Binding pKi = 7.2 7.2 2 3
Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptorInhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor
ChEMBL 646 11 7 6 1.6 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
443375 207604 None 45 Human Binding pKi = 7.2 7.2 -316 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80686-1
CHEMBL9506 207604 None 45 Human Binding pKi = 7.2 7.2 -316 5
The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex.
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1016/S0960-894X(00)80686-1
10793449 168661 None 0 Human Binding pKi = 6.2 6.2 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL436382 168661 None 0 Human Binding pKi = 6.2 6.2 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
10650978 116636 None 0 Human Binding pKi = 7.2 7.2 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL336965 116636 None 0 Human Binding pKi = 7.2 7.2 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
45486940 198883 None 0 Human Binding pKi = 7.2 7.2 31 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL584259 198883 None 0 Human Binding pKi = 7.2 7.2 31 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11363566 81059 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 476 4 1 6 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
CHEMBL215416 81059 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 476 4 1 6 2.7 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCOCC1 10.1021/jm060590x
11385416 82491 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCCC1 10.1021/jm060590x
CHEMBL217720 82491 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 450 4 1 6 4.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCCC1 10.1021/jm060590x
16090797 82580 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 512 5 1 6 5.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(c2ccccc2)CC1 10.1021/jm060590x
CHEMBL217878 82580 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 512 5 1 6 5.2 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCC(c2ccccc2)CC1 10.1021/jm060590x
44417427 96625 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 475 4 1 6 3.2 O=C(c1ccc(Br)nc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL263475 96625 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 475 4 1 6 3.2 O=C(c1ccc(Br)nc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1021/jm060590x
11454197 141862 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.1 O=C(c1ccc(C(F)(F)F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL386598 141862 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 470 4 1 6 4.1 O=C(c1ccc(C(F)(F)F)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11465671 96368 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 474 4 1 5 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL261682 96368 None 0 Human Binding pKi = 7.2 7.2 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 474 4 1 5 3.8 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2nccnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
45486941 196762 None 0 Human Binding pKi = 6.2 6.2 -1 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 7 2 6 4.2 O=C(NCCc1ccccc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL565325 196762 None 0 Human Binding pKi = 6.2 6.2 -1 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 7 2 6 4.2 O=C(NCCc1ccccc1)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
45486968 197467 None 0 Human Binding pKi = 6.2 6.2 -1 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569848 197467 None 0 Human Binding pKi = 6.2 6.2 -1 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 550 8 3 7 4.2 O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11627917 197528 None 0 Human Binding pKi = 6.2 6.2 -7 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 CC(CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
CHEMBL570163 197528 None 0 Human Binding pKi = 6.2 6.2 -7 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 530 7 2 6 4.8 CC(CNC(=O)c1ccc(Br)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccccc1 10.1016/j.bmcl.2009.09.064
25033224 94482 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 524 4 1 3 5.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1Cl)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251467 94482 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 524 4 1 3 5.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1Cl)N1CCCCC1 10.1016/j.bmcl.2007.09.087
11316421 82398 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 5 1 7 3.1 COc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL217270 82398 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 432 5 1 7 3.1 COc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
16090653 82415 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL217373 82415 None 0 Human Binding pKi = 6.2 6.2 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 460 4 1 6 3.3 C[C@H]1COC[C@@H](C)N1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
44404001 11931 None 0 Mouse Binding pKi = 6.2 6.2 6 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 635 11 6 6 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm049069y
CHEMBL1182744 11931 None 0 Mouse Binding pKi = 6.2 6.2 6 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 635 11 6 6 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm049069y
CHEMBL2067969 11931 None 0 Mouse Binding pKi = 6.2 6.2 6 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 635 11 6 6 4.5 O=C(NCC12CC3CC(CC(C3)C1)C2)c1cc2nc[nH]c2cc1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(CO)cc(CO)c1 10.1021/jm049069y
11535277 12277 None 0 Mouse Binding pKi = 6.2 6.2 10 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 513 8 4 4 5.9 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL1184817 12277 None 0 Mouse Binding pKi = 6.2 6.2 10 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 513 8 4 4 5.9 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
CHEMBL2067964 12277 None 0 Mouse Binding pKi = 6.2 6.2 10 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 513 8 4 4 5.9 O=C(O)c1cc(NC(=O)c2[nH]c(-c3ccccc3)nc2CCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm049069y
45486967 197421 None 0 Human Binding pKi = 5.2 5.2 -39 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 472 7 2 6 4.1 O=C(NCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL569616 197421 None 0 Human Binding pKi = 5.2 5.2 -39 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 472 7 2 6 4.1 O=C(NCCc1ccccc1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
44445283 94154 None 0 Human Binding pKi = 5.2 5.2 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 561 7 2 5 4.9 O=C(NCc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)s1)c1ccccc1 10.1016/j.bmcl.2007.09.087
CHEMBL249452 94154 None 0 Human Binding pKi = 5.2 5.2 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 561 7 2 5 4.9 O=C(NCc1ccc(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)s1)c1ccccc1 10.1016/j.bmcl.2007.09.087
11568611 71977 None 0 Mouse Binding pKi = 7.2 7.2 -6 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL197370 71977 None 0 Mouse Binding pKi = 7.2 7.2 -6 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 449 6 3 3 5.8 CC(C)(C)c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC23CC4CC(CC(C4)C2)C3)[nH]1 10.1021/jm0490686
CHEMBL3351051 211533 None 0 Human Binding pKi = 7.2 7.2 17 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)NC)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
4595 176713 None 106 Rat Binding pKi = 6.2 6.2 -6 15
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
ChEMBL 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O 10.1021/jm00075a026
CHEMBL46 176713 None 106 Rat Binding pKi = 6.2 6.2 -6 15
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
ChEMBL 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O 10.1021/jm00075a026
46235271 73646 None 2 Human Binding pKi = 7.2 7.2 -2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
CHEMBL2017835 73646 None 2 Human Binding pKi = 7.2 7.2 -2 2
Displacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-BDZ-2] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 649 7 1 6 6.7 Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2C(=O)[C@@H](Cc3n[nH]c4ccccc34)c3nnc(-c4ccccc4)n3-c3ccccc32)c1 10.1021/acs.jmedchem.5b01110
9867157 100240 None 7 Mouse Binding pKi = 4.2 4.2 -194 2
Compound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortexCompound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 426 9 3 4 2.3 O=C(O)C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80008-6
CHEMBL288641 100240 None 7 Mouse Binding pKi = 4.2 4.2 -194 2
Compound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortexCompound was evaluated for its affinity against Cholecystokinin type B receptor in mouse cerebral cortex
ChEMBL 426 9 3 4 2.3 O=C(O)C[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)NCCc1ccccc1 10.1016/S0960-894X(00)80008-6
108187 925 None 37 Rat Binding pKi = 8.1 8.1 -295 5
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
873 925 None 37 Rat Binding pKi = 8.1 8.1 -295 5
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL2062154 925 None 37 Rat Binding pKi = 8.1 8.1 -295 5
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
CHEMBL287735 925 None 37 Rat Binding pKi = 8.1 8.1 -295 5
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 614 12 5 5 4.9 O=C(N[C@H](c1ccccc1)CNC(=O)[C@@](Cc1c[nH]c2c1cccc2)(NC(=O)OC1C2CC3CC1CC(C2)C3)C)CCC(=O)O 10.1021/jm970439a
44580899 189073 None 0 Human Binding pKi = 8.1 8.1 -4 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 189073 None 0 Human Binding pKi = 8.1 8.1 -4 2
Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL330785 211333 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CC(=O)O)NC(=O)OC(C)(C)C 10.1021/jm0000416
10676212 116007 None 0 Mouse Binding pKi = 8.1 8.1 489 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL335587 116007 None 0 Mouse Binding pKi = 8.1 8.1 489 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44451519 95755 None 0 Human Binding pKi = 8.1 8.1 58 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 6 1 4 6.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL258486 95755 None 0 Human Binding pKi = 8.1 8.1 58 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 518 6 1 4 6.1 Cc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
16732753 143984 None 0 Human Binding pKi = 8.1 8.1 1 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL390276 143984 None 0 Human Binding pKi = 8.1 8.1 1 3
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 552 8 2 5 5.7 Cc1ccccc1C(=O)CN1C(=O)N(CC(=O)Nc2cccc(C(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
44212230 4258 None 0 Human Binding pKi = 8.1 8.1 208 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 572 8 1 5 5.9 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
CHEMBL100509 4258 None 0 Human Binding pKi = 8.1 8.1 208 2
Evaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptorEvaluated in vitro for Cholecystokinin type B receptor affinity by measuring its ability to displace tritiated CCK-8S bound on guinea pig brain Cholecystokinin type B receptor
ChEMBL 572 8 1 5 5.9 CC(C)CCN1C(=O)C(NC(=O)Oc2cccc(N(C)C)c2)C(=O)N(CC23CC4CC(CC(C4)C2)C3)c2ccccc21 10.1016/S0960-894X(96)00544-6
9986662 102026 None 10 Mouse Binding pKi = 8.1 8.1 977 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 643 11 6 6 4.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL301777 102026 None 10 Mouse Binding pKi = 8.1 8.1 977 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 643 11 6 6 4.8 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2F)NC(=O)c2cc3[nH]cnc3cc2C(=O)NCC2CCCCCC2)cc(C(=O)O)c1 10.1021/jm9508907
CHEMBL120452 208600 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)OC(C)(C)C 10.1021/jm0000416
5311201 207393 None 35 Human Binding pKi = 8.1 8.1 -27 6
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
CHEMBL9387 207393 None 35 Human Binding pKi = 8.1 8.1 -27 6
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 398 3 2 3 4.0 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(C)C2=O)c1 10.1021/jm051219x
10695854 114001 None 0 Human Binding pKi = 8.1 8.1 25 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
CHEMBL332646 114001 None 0 Human Binding pKi = 8.1 8.1 25 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 474 6 2 3 5.1 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2F)c2ccccc21 10.1021/jm990967h
145978895 166463 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
CHEMBL4278080 166463 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysisDisplacement of non-sulfated CCK-8 from CCKB receptor (unknown origin) expressed in HEK cells after 4 hrs by RP-LC-ICPMS analysis
ChEMBL 1063 32 12 10 0.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCNC(=O)[C@H](CCCNC(=N)N)NC(=O)C[Se]c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/acs.jmedchem.8b01320
10795162 119036 None 0 Mouse Binding pKi = 8.1 8.1 630 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL2067970 119036 None 0 Mouse Binding pKi = 8.1 8.1 630 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL342616 119036 None 0 Mouse Binding pKi = 8.1 8.1 630 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 751 11 5 5 6.6 O=C(O)c1cc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
11605814 75426 None 0 Human Binding pKi = 8.1 8.1 -6 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL204154 75426 None 0 Human Binding pKi = 8.1 8.1 -6 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 503 7 2 5 5.5 CNc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
10818497 25850 None 0 Mouse Binding pKi = 7.2 7.2 58 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL135344 25850 None 0 Mouse Binding pKi = 7.2 7.2 58 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 701 8 4 5 5.9 O=C(O)c1cc(NC(=O)[C@@H]2CCCN2C(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc(C(=O)O)c1 10.1021/jm00021a019
44357069 155691 None 0 Mouse Binding pKi = 7.2 7.2 147 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 675 9 5 5 5.4 C[C@@H](NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm00021a019
CHEMBL405062 155691 None 0 Mouse Binding pKi = 7.2 7.2 147 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 675 9 5 5 5.4 C[C@@H](NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 10.1021/jm00021a019
52949124 875 None 4 Human Binding pKi = 7.2 7.2 2 2
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
9055 875 None 4 Human Binding pKi = 7.2 7.2 2 2
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
CHEMBL1269258 875 None 4 Human Binding pKi = 7.2 7.2 2 2
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
DB12694 875 None 4 Human Binding pKi = 7.2 7.2 2 2
Displacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counterDisplacement of [125I-CCK] from wild-type human CCK2R at allosteric site expressed in CHO cells after 60 mins by scintillation counter
ChEMBL 594 8 1 5 6.5 CC(N(C(=O)CN1c2ccccc2n2c([C@@H](C1=O)Cc1c[nH]c3c1cccc3)nnc2c1ccccc1)Cc1ccccc1)C 10.1021/acs.jmedchem.5b01110
10072464 109744 None 0 Human Binding pKi = 4.2 4.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 450 8 4 4 2.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80669-1
CHEMBL32301 109744 None 0 Human Binding pKi = 4.2 4.2 - 1
Inhibitory activity against Cholecystokinin type B receptorInhibitory activity against Cholecystokinin type B receptor
ChEMBL 450 8 4 4 2.8 CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/S0960-894X(00)80669-1
44580899 189073 None 0 Human Binding pKi = 7.2 7.2 -4 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL509792 189073 None 0 Human Binding pKi = 7.2 7.2 -4 2
Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells
ChEMBL 1001 19 8 14 1.1 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
16100407 82669 None 0 Human Binding pKi = 7.2 7.2 -112 3
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL217957 82669 None 0 Human Binding pKi = 7.2 7.2 -112 3
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1132 28 13 13 1.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL3351050 211532 None 0 Human Binding pKi = 7.2 7.2 33 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CC(C)(C)OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12 10.1021/jm00053a022
CHEMBL171594 208846 None 0 Human Binding pKi = 7.2 7.2 33 2
Tested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 to Cholecystokinin type B receptor in guinea pig brain
ChEMBL None None None CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O 10.1016/S0960-894X(00)80678-2
10482868 107402 None 0 Mouse Binding pKi = 7.1 7.1 -5 5
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL317999 107402 None 0 Mouse Binding pKi = 7.1 7.1 -5 5
Tested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligandTested for binding affinity towards cholecystokinin type B receptor in mouse brain by displacement of [3H]pBC264 radioligand
ChEMBL 557 10 3 4 5.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
118719284 115480 None 0 Human Binding pKi = 7.1 7.1 72 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 739 15 5 7 4.9 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)C1CCCCC1 10.1021/jm00053a022
CHEMBL3351056 115480 None 0 Human Binding pKi = 7.1 7.1 72 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 739 15 5 7 4.9 CN(C)[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C)C1CCCCC1 10.1021/jm00053a022
11663308 76743 None 1 Human Binding pKi = 7.1 7.1 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL206709 76743 None 1 Human Binding pKi = 7.1 7.1 1 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 497 7 2 5 5.0 CNc1cccc(NC(=O)CN2N=C(c3ccccc3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
44351454 116816 None 0 Rat Binding pKi = 7.1 7.1 -1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL337933 116816 None 0 Rat Binding pKi = 7.1 7.1 -1 2
Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.Compound was tested for binding affinity against rat brain Cholecystokinin type B receptor expressed in CHO cells.
ChEMBL 712 8 3 6 5.1 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc(I)cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10604230 115210 None 0 Mouse Binding pKi = 6.1 6.1 5 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL334523 115210 None 0 Mouse Binding pKi = 6.1 6.1 5 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 645 10 4 4 4.8 O=C(O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
44351446 156139 None 0 Human Binding pKi = 7.1 7.1 3 2
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL406359 156139 None 0 Human Binding pKi = 7.1 7.1 3 2
Binding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cellsBinding affinity (affinity state 2) for Cholecystokinin type B receptor, was determined using CHO cells
ChEMBL 631 9 3 8 4.4 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccc([N+](=O)[O-])cc2)C[C@@H]1C(=O)O 10.1021/jm970439a
15297879 114453 None 0 Mouse Binding pKi = 5.1 5.1 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 436 5 3 2 4.4 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCc1c[nH]c2ccccc12 10.1021/jm00048a001
CHEMBL333409 114453 None 0 Mouse Binding pKi = 5.1 5.1 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 436 5 3 2 4.4 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCc1c[nH]c2ccccc12 10.1021/jm00048a001
44580900 188438 None 0 Human Binding pKi = 7.1 7.1 -2 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL502398 188438 None 0 Human Binding pKi = 7.1 7.1 -2 2
Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cellsDisplacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells
ChEMBL 1057 23 8 14 2.6 CN1C(=O)[C@H](NC(=O)Nc2cccc(OCCNC(=O)COCC(=O)NCCCCCCNC(=O)COCC(=O)N[C@H]3CC[C@@]4(O)[C@H]5Cc6cc(O)cc7c6[C@@]4(CCN5C)[C@H]3O7)c2)N=C(c2ccccc2)c2ccccc21 10.1021/jm800174p
CHEMBL3351061 211540 None 0 Human Binding pKi = 6.1 6.1 4 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL None None None CN(C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1cccc2ccccc12)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
16100410 141796 None 0 Human Binding pKi = 5.1 5.1 -7079 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL386212 141796 None 0 Human Binding pKi = 5.1 5.1 -7079 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@H](Cc1cc2ccccc2[nH]1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
44351413 18148 None 0 Human Binding pKi = 6.1 6.1 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 636 8 3 6 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2cccc3ccccc23)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL126957 18148 None 0 Human Binding pKi = 6.1 6.1 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 636 8 3 6 5.7 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)ON1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2cccc3ccccc23)C[C@@H]1C(=O)O 10.1021/jm970439a
11541870 71449 None 0 Mouse Binding pKi = 6.1 6.1 -10 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
CHEMBL196141 71449 None 0 Mouse Binding pKi = 6.1 6.1 -10 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 433 7 3 3 5.4 O=C(O)c1cccc(NC(=O)c2[nH]c(C3CC3)nc2CCC23CC4CC(CC(C4)C2)C3)c1 10.1021/jm0490686
44346825 114771 None 0 Mouse Binding pKi = 6.1 6.1 77 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
CHEMBL333920 114771 None 0 Mouse Binding pKi = 6.1 6.1 77 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 623 8 3 4 4.7 C[C@@H](NC(=O)C[C@@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC1C2CC3CC(C2)CC1C3)C(=O)O 10.1021/jm00048a001
44280155 102906 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL30605 102906 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
10325110 111985 None 0 Human Binding pKi = 7.1 7.1 29 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 544 9 3 5 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc([N+](=O)[O-])cc1 10.1021/jm00072a005
CHEMBL328852 111985 None 0 Human Binding pKi = 7.1 7.1 29 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 544 9 3 5 5.3 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccc([N+](=O)[O-])cc1 10.1021/jm00072a005
45486949 196943 None 0 Human Binding pKi = 7.1 7.1 50 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL566390 196943 None 0 Human Binding pKi = 7.1 7.1 50 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 516 8 3 7 3.6 O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
11464858 81572 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 440 4 1 7 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCSC1 10.1021/jm060590x
CHEMBL216233 81572 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 440 4 1 7 3.3 O=C(c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)N1CCSC1 10.1021/jm060590x
25033148 96019 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2scnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL259762 96019 None 0 Human Binding pKi = 7.1 7.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2scnc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
44280575 96662 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL263803 96662 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
11801461 116983 None 0 Human Binding pKi = 6.1 6.1 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
CHEMBL338752 116983 None 0 Human Binding pKi = 6.1 6.1 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@H]1C(=O)O 10.1021/jm970439a
10698109 107294 None 0 Human Binding pKi = 6.1 6.1 -5 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
CHEMBL317181 107294 None 0 Human Binding pKi = 6.1 6.1 -5 2
Binding affinity at human CCK2 receptorBinding affinity at human CCK2 receptor
ChEMBL 560 8 1 4 5.8 CC(C)N(C(=O)CN1C(=O)C(CC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccccc21)c1ccccc1 10.1016/j.bmc.2007.12.047
25033225 94484 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 540 4 1 4 5.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1sc(Cl)cc1Br)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL251486 94484 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 540 4 1 4 5.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1sc(Cl)cc1Br)N1CCCCC1 10.1016/j.bmcl.2007.09.087
11271596 82279 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1cc(Br)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
CHEMBL217169 82279 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 480 4 1 6 3.9 O=C(c1cc(Br)ccc1NS(=O)(=O)c1cccc2nsnc12)N1CCCCC1 10.1021/jm060590x
11442229 141794 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
CHEMBL386209 141794 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 446 4 1 6 2.9 C[C@H]1COCCN1C(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nccnc12 10.1021/jm060590x
16090784 141912 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1021/jm060590x
CHEMBL386976 141912 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1021/jm060590x
25032468 96359 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2n1 10.1016/j.bmc.2008.01.059
CHEMBL261636 96359 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 477 4 1 6 3.2 Cn1nc2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2n1 10.1016/j.bmc.2008.01.059
16090784 141912 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL386976 141912 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 473 4 1 4 4.4 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncccc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
25033150 159914 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncsc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
CHEMBL410708 159914 None 0 Human Binding pKi = 6.1 6.1 - 1
Displacement of [125I]CCK8S from human CCK2RDisplacement of [125I]CCK8S from human CCK2R
ChEMBL 479 4 1 5 4.5 O=C(c1ccc(Br)cc1NS(=O)(=O)c1cccc2ncsc12)N1CCCCC1 10.1016/j.bmc.2008.01.059
9869202 72074 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL197716 72074 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm049069y
CHEMBL2067960 72074 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Inhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptorInhibition of 20 pM [125I]BH-CCK-8S binding to mouse cortical membrane Cholecystokinin 2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm049069y
11512151 196784 None 0 Human Binding pKi = 5.1 5.1 -158 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 534 7 2 6 5.5 CC(C)(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
CHEMBL565511 196784 None 0 Human Binding pKi = 5.1 5.1 -158 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 534 7 2 6 5.5 CC(C)(CNC(=O)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.09.064
45487003 197588 None 0 Human Binding pKi = 5.1 5.1 -100 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 540 7 2 6 5.4 O=C(NCCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
CHEMBL570521 197588 None 0 Human Binding pKi = 5.1 5.1 -100 2
Displacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation countingDisplacement of [125I]-CCK-8S from CCK2R after 100 mins by liquid scintillation counting
ChEMBL 540 7 2 6 5.4 O=C(NCCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1NS(=O)(=O)c1cccc2nsnc12 10.1016/j.bmcl.2009.09.064
25033382 94155 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 630 6 1 6 6.4 COC(=O)c1sc(C(F)(F)F)c(-c2ccccc2)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
CHEMBL249468 94155 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 630 6 1 6 6.4 COC(=O)c1sc(C(F)(F)F)c(-c2ccccc2)c1S(=O)(=O)Nc1cc(Br)ccc1C(=O)N1CCCCC1 10.1016/j.bmcl.2007.09.087
25033384 94517 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 504 5 1 6 4.2 Cc1nnc(-c2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2)o1 10.1016/j.bmcl.2007.09.087
CHEMBL251653 94517 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 504 5 1 6 4.2 Cc1nnc(-c2cccc(S(=O)(=O)Nc3cc(Br)ccc3C(=O)N3CCCCC3)c2)o1 10.1016/j.bmcl.2007.09.087
25033383 167414 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 5 1 5 4.4 Cc1c(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cnn1-c1ccccc1 10.1016/j.bmcl.2007.09.087
CHEMBL429662 167414 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from CCK2 receptorDisplacement of [125I]CCK-8S from CCK2 receptor
ChEMBL 502 5 1 5 4.4 Cc1c(S(=O)(=O)Nc2cc(Br)ccc2C(=O)N2CCCCC2)cnn1-c1ccccc1 10.1016/j.bmcl.2007.09.087
11292979 82062 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 417 4 2 7 2.7 Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
CHEMBL216559 82062 None 0 Human Binding pKi = 5.1 5.1 - 1
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 417 4 2 7 2.7 Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1 10.1021/jm060590x
16090789 83248 None 0 Human Binding pKi = 5.1 5.1 -3 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 521 6 2 7 4.4 O=C(Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1)c1ccccc1 10.1021/jm060590x
CHEMBL218729 83248 None 0 Human Binding pKi = 5.1 5.1 -3 2
Displacement of [125I]CCK-8S from human CCK2RDisplacement of [125I]CCK-8S from human CCK2R
ChEMBL 521 6 2 7 4.4 O=C(Nc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2cccc3nsnc23)c1)c1ccccc1 10.1021/jm060590x
11799257 113465 None 0 Human Binding pKi = 8.1 8.1 32 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 490 6 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(CCc2ccccc2)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL331929 113465 None 0 Human Binding pKi = 8.1 8.1 32 2
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 490 6 2 3 5.1 O=C(Nc1ccccc1)NC1C(=O)N(CCc2ccccc2)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
5311347 33024 None 3 Mouse Binding pKi = 8.1 8.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
CHEMBL141630 33024 None 3 Mouse Binding pKi = 8.1 8.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 557 10 4 4 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N[C@@H](CC(=O)O)Cc1ccccc1 10.1021/jm00087a011
10480793 115423 None 0 Mouse Binding pKi = 8.1 8.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
CHEMBL3350395 115423 None 0 Mouse Binding pKi = 8.1 8.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 491 9 4 4 4.5 C[C@@H]1CCCC[C@H]1OC(=O)N[C@](C)(Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1 10.1021/jm00087a011
11540402 138801 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 488 6 1 4 5.8 Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
CHEMBL378098 138801 None 0 Human Binding pKi = 8.1 8.1 - 1
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 488 6 1 4 5.8 Cc1cccc(NC(=O)CN2N=C(C3CCCCC3)c3ccccc3N(CC(=O)C(C)(C)C)C2=O)c1 10.1021/jm051219x
10439779 106684 None 0 Rat Binding pKi = 7.1 7.1 -1 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
CHEMBL3143501 106684 None 0 Rat Binding pKi = 7.1 7.1 -1 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL 710 11 7 8 2.2 C[C@]1(Cc2c[nH]c3ccccc23)NC(=O)CCCCSSCC[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC1=O 10.1021/jm9603072
118719287 115482 None 0 Human Binding pKi = 7.1 7.1 6 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 727 17 4 7 4.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)N(C)C)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
CHEMBL3351059 115482 None 0 Human Binding pKi = 7.1 7.1 6 2
Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membraneDisplacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane
ChEMBL 727 17 4 7 4.8 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cccc2ccccc12)N(C)C)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C 10.1021/jm00053a022
118719251 115467 None 0 Mouse Binding pKi = 7.1 7.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 11 5 5 4.6 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
CHEMBL3351015 115467 None 0 Mouse Binding pKi = 7.1 7.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 11 5 5 4.6 CC1(C)C2CCC1(C)[C@@H](OC(=O)N[C@H](Cc1c[nH]c3ccccc13)C(=O)NC[C@H](NC(=O)/C=C/C(=O)O)c1ccccc1)C2 10.1021/jm00087a011
44280595 117970 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL34037 117970 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@H](Oc2ccc(Cl)cc2Cl)C[C@@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
15024387 115421 None 0 Mouse Binding pKi = 6.1 6.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3350393 115421 None 0 Mouse Binding pKi = 6.1 6.1 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 515 9 4 4 4.4 O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CO)Cc1ccccc1)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
9869202 72074 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL197716 72074 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm0490686
CHEMBL2067960 72074 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 467 6 3 3 6.7 O=C(O)c1cccc(NC(=O)c2[nH]c(-c3ccc4ccccc4c3)nc2CC2CCCCCC2)c1 10.1021/jm0490686
11679213 133541 None 0 Mouse Binding pKi = 7.1 7.1 -8 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
CHEMBL370882 133541 None 0 Mouse Binding pKi = 7.1 7.1 -8 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 497 7 3 3 6.8 Cc1ccc(-c2nc(C(=O)Nc3cccc(C(=O)O)c3)c(CCC34CC5CC(CC(C5)C3)C4)[nH]2)c(C)c1 10.1021/jm0490686
9850043 112871 None 2 Human Binding pKi = 7.1 7.1 1 3
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
CHEMBL330977 112871 None 2 Human Binding pKi = 7.1 7.1 1 3
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranesIn vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes
ChEMBL 534 5 2 3 6.1 O=C(Nc1ccccc1)NC1C(=O)N(CC23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)c2ccccc2N(c2ccccc2)C1=O 10.1021/jm990967h
44356654 28107 None 0 Mouse Binding pKi = 5.1 5.1 -1 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 691 9 3 3 7.8 Cc1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C 10.1021/jm00021a019
CHEMBL137308 28107 None 0 Mouse Binding pKi = 5.1 5.1 -1 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 691 9 3 3 7.8 Cc1ccc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)cc1C 10.1021/jm00021a019
11685703 71918 None 0 Mouse Binding pKi = 5.1 5.1 -316 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
CHEMBL197205 71918 None 0 Mouse Binding pKi = 5.1 5.1 -316 3
Concentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptorConcentration required to inhibit the binding of 20 pM [125I]-BH-CCK-8S radioligand to mouse cortical membrane CCK2 receptor
ChEMBL 391 7 3 3 4.9 Cc1ccccc1-c1nc(C(=O)Nc2cccc(C(=O)O)c2)c(CCC(C)C)[nH]1 10.1021/jm0490686
44357045 26573 None 0 Rat Binding pKi = 7.1 7.1 -85 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL136096 26573 None 0 Rat Binding pKi = 7.1 7.1 -85 2
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
ChEMBL 1012 28 9 13 0.7 CSCC[C@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm970477u
CHEMBL2369815 209691 None 0 Rat Binding pKi = 7.1 7.1 -85 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL None None None CSCC[C@@H](NC(=O)Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(=O)O)C(=O)N(C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL333477 211390 None 0 Rat Binding pKi = 7.1 7.1 -19 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1021/jm9603072
10323690 100496 None 0 Human Binding pKi = 7.1 7.1 21 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL2114401 100496 None 0 Human Binding pKi = 7.1 7.1 21 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00072a005
CHEMBL291033 100496 None 0 Human Binding pKi = 7.1 7.1 21 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 499 8 3 3 5.4 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1ccccc1 10.1021/jm00072a005
10324322 107703 None 0 Human Binding pKi = 7.1 7.1 43 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 518 10 2 4 4.7 CC(Cc1ccccc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
CHEMBL319085 107703 None 0 Human Binding pKi = 7.1 7.1 43 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 518 10 2 4 4.7 CC(Cc1ccccc1)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N(CCc1ccccc1)CC(=O)O 10.1021/jm00072a005
44356826 119304 None 0 Mouse Binding pKi = 7.1 7.1 19 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 781 12 5 6 6.6 COc1ccc(C[C@@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)C(=O)Nc2cc(C(=O)O)cc(C(=O)O)c2)cc1 10.1021/jm00021a019
CHEMBL344014 119304 None 0 Mouse Binding pKi = 7.1 7.1 19 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 781 12 5 6 6.6 COc1ccc(C[C@@H](NC(=O)C2C3c4ccccc4C(c4ccccc43)C2C(=O)NCC23CC4CC(CC(C4)C2)C3)C(=O)Nc2cc(C(=O)O)cc(C(=O)O)c2)cc1 10.1021/jm00021a019
443375 207604 None 45 Human Binding pKi = 7.1 7.1 -316 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
CHEMBL9506 207604 None 45 Human Binding pKi = 7.1 7.1 -316 5
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pigInhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig
ChEMBL 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 10.1021/jm990967h
10698746 116783 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
CHEMBL337743 116783 None 0 Mouse Binding pKi = 6.1 6.1 3 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 595 7 3 4 4.0 O=C(O)CNC(=O)[C@H]1CCCN1C(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3 10.1021/jm00021a019
10794691 117060 None 0 Mouse Binding pKi = 6.1 6.1 -1 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 684 10 5 4 5.3 O=C(O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
CHEMBL339177 117060 None 0 Mouse Binding pKi = 6.1 6.1 -1 2
Competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesCompetition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 684 10 5 4 5.3 O=C(O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCC12CC3CC(CC(C3)C1)C2 10.1021/jm00021a019
9985004 207616 None 0 Human Binding pKi = 7.1 7.1 26 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 549 8 3 3 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1cccc2ccccc12 10.1021/jm00072a005
CHEMBL95115 207616 None 0 Human Binding pKi = 7.1 7.1 26 2
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 549 8 3 3 6.5 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCCc1cccc2ccccc12 10.1021/jm00072a005
44425005 142452 None 0 Human Binding pKi = 7.1 7.1 79 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 478 7 2 5 4.2 CC(C)C1=NN(CC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(CC(=O)C(C)(C)C)c2ccccc21 10.1021/jm070139l
CHEMBL389019 142452 None 0 Human Binding pKi = 7.1 7.1 79 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 478 7 2 5 4.2 CC(C)C1=NN(CC(=O)Nc2cccc(C(=O)O)c2)C(=O)N(CC(=O)C(C)(C)C)c2ccccc21 10.1021/jm070139l
10651206 115087 None 0 Mouse Binding pKi = 6.1 6.1 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 8 2 5 4.6 CC(=O)N1[C@H](C(=O)NCCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL334320 115087 None 0 Mouse Binding pKi = 6.1 6.1 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 599 8 2 5 4.6 CC(=O)N1[C@H](C(=O)NCCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
44296980 102020 None 0 Mouse Binding pKi = 6.1 6.1 9 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 538 5 2 3 4.9 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
CHEMBL301740 102020 None 0 Mouse Binding pKi = 6.1 6.1 9 2
In vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranesIn vitro inhibitory activity against Cholecystokinin type B receptor using [125I]BH-CCK-8S as radioligand in mouse cortical membranes
ChEMBL 538 5 2 3 4.9 O=C(NCC12CC3CC(CC(C3)C1)C2)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm9508907
44346952 114111 None 0 Mouse Binding pKi = 6.1 6.1 9 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 538 5 2 3 4.8 O=C(NCC1C2CC3CC(C2)CC1C3)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm00048a001
CHEMBL332782 114111 None 0 Mouse Binding pKi = 6.1 6.1 9 2
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 538 5 2 3 4.8 O=C(NCC1C2CC3CC(C2)CC1C3)C1C2c3ccccc3C(c3ccccc32)C1C(=O)N1CCC[C@@H]1C(=O)O 10.1021/jm00048a001
15297881 113503 None 0 Mouse Binding pKi = 5.1 5.1 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 411 6 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCCc1ccccc1 10.1021/jm00048a001
CHEMBL332061 113503 None 0 Mouse Binding pKi = 5.1 5.1 - 1
Tested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenatesTested for its receptor affinity from competition with 20 pM [125I]BH-CCK-8S for Cholecystokinin type B receptor binding sites in mouse cortical homogenates
ChEMBL 411 6 2 2 4.3 O=C(O)C1C2c3ccccc3C(c3ccccc32)C1C(=O)NCCCc1ccccc1 10.1021/jm00048a001
44280156 168318 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
CHEMBL434199 168318 None 0 Rat Binding pKi = 6.1 6.1 - 1
Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorCapacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptor
ChEMBL 667 8 3 5 6.9 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)N1CC[C@@H](Oc2ccc(Cl)cc2Cl)C[C@H]1C(=O)O 10.1016/s0960-894x(98)00231-5
44272041 97081 None 0 Human Binding pKi = 8.0 8.0 338 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
CHEMBL267329 97081 None 0 Human Binding pKi = 8.0 8.0 338 2
Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranesDisplacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes
ChEMBL 1274 26 13 15 2.1 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc2ccc(OS(=O)(=O)O)cc2)C(=O)N[C@@H](CCCC)C(=O)N1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00126a007
11642370 140169 None 0 Human Binding pKi = 8.0 8.0 95 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
CHEMBL380363 140169 None 0 Human Binding pKi = 8.0 8.0 95 2
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 540 7 1 6 5.7 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2cccc(-n3ccnc3)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm051219x
16732592 143580 None 1 Human Binding pKi = 8.0 8.0 870 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(cnn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL389933 143580 None 1 Human Binding pKi = 8.0 8.0 870 2
Displacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [3H]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 572 8 2 7 4.9 CC(C)(C)C(=O)CN1C(=O)N(CC(=O)Nc2ccc3c(cnn3CC(=O)O)c2)N=C(C2CCCCC2)c2ccccc21 10.1021/jm070139l
CHEMBL64605 215854 None 7 Rat Binding pKi = 8.0 8.0 4 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
44451877 95979 None 0 Human Binding pKi = 8.0 8.0 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
CHEMBL259557 95979 None 0 Human Binding pKi = 8.0 8.0 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 587 7 1 6 6.9 Cc1nc(-c2cccc(NC(=O)CN3C(=O)N(CC(=O)C(C)(C)C)c4ccccc4N(C4CCCCC4)C3=O)c2)cs1 10.1016/j.bmc.2007.12.047
44451920 96124 None 0 Human Binding pKi = 8.0 8.0 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
CHEMBL260394 96124 None 0 Human Binding pKi = 8.0 8.0 2 3
Displacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cellsDisplacement of [125I]BH-CCK-8S from human recombinant CCK2 receptor expressed in NIH3T3 cells
ChEMBL 519 7 2 5 5.5 CNc1cccc(NC(=O)CN2C(=O)N(CC(=O)C(C)(C)C)c3ccccc3N(C3CCCCC3)C2=O)c1 10.1016/j.bmc.2007.12.047
10698558 117219 None 0 Human Binding pKi = 7.0 7.0 -3 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL339451 117219 None 0 Human Binding pKi = 7.0 7.0 -3 2
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL120632 208603 None 33 Rat Binding pKi = 7.0 7.0 -5 3
Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cellsAffinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm9603072
CHEMBL3350665 211480 None 0 Human Binding pKi = 7.0 7.0 3 2
Apparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranesApparent affinity to inhibit binding of [3H]pCCK-8 to Cholecystokinin type B receptor of guinea pig brain membranes
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(S(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00174a016
CHEMBL120632 208603 None 33 Rat Binding pKi = 7.0 7.0 -5 3
Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm0000416
118718880 115422 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL3350394 115422 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 543 10 4 4 4.8 O=C(O)C[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3 10.1021/jm00087a011
CHEMBL1172246 208579 None 0 Human Binding pKi = 6.0 6.0 -1 4
Displacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cellsDisplacement of [125I]CCK-8(SO3) from human CCK2 receptor expressed in human HEK293 cells
ChEMBL None None None N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CC(=O)NCCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC1=O 10.1016/j.bmcl.2010.05.078
44408483 168927 None 0 Human Binding pKi = 6.0 6.0 -275 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL438739 168927 None 0 Human Binding pKi = 6.0 6.0 -275 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1212 31 12 15 3.7 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1cn(C(=O)OC2C3CC4CC(C3)CC2C4)c2ccccc12)C(=O)O 10.1021/jm050851n
44408484 137506 None 0 Human Binding pKi = 5.0 5.0 -18197 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
CHEMBL375412 137506 None 0 Human Binding pKi = 5.0 5.0 -18197 4
Displacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1033 30 13 12 1.4 CCCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NN[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm050851n
44418924 156880 None 0 Human Binding pKi = 5.0 5.0 -18620 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
CHEMBL407198 156880 None 0 Human Binding pKi = 5.0 5.0 -18620 4
Displacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cellsDisplacement of [125I]CCK8-SO3 from human CCK2 receptor expressed in HEK293 cells
ChEMBL 1031 27 13 12 0.2 CCCC[C@H](NC(=O)[C@H](N)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1 10.1021/jm061268p
10839906 110426 None 0 Mouse Binding pKi = 6.0 6.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 528 5 1 4 5.1 CC(=O)N1[C@H](C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL324557 110426 None 0 Mouse Binding pKi = 6.0 6.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 528 5 1 4 5.1 CC(=O)N1[C@H](C(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
10676691 15561 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 663 19 7 7 0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCN 10.1021/jm0000416
CHEMBL122012 15561 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 663 19 7 7 0.7 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCN 10.1021/jm0000416
19043358 4359 None 0 Human Binding pKi = 6.0 6.0 -22 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(Cl)cc21 10.1016/0960-894X(95)00528-2
CHEMBL101125 4359 None 0 Human Binding pKi = 6.0 6.0 -22 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2ccc(Cl)cc21 10.1016/0960-894X(95)00528-2
19043395 4771 None 0 Human Binding pKi = 6.0 6.0 -194 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)ccc21 10.1016/0960-894X(95)00528-2
CHEMBL103968 4771 None 0 Human Binding pKi = 6.0 6.0 -194 2
Binding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brainBinding affinity was measured by its ability to displace [3H]CCK-8S from CCK-B receptor in guinea pig brain
ChEMBL 490 6 2 3 5.6 CC(C)CCN1C(=O)C(NC(=O)Nc2ccccc2)C(=O)N(c2ccccc2)c2cc(Cl)ccc21 10.1016/0960-894X(95)00528-2
CHEMBL384035 212314 None 4 Rat Binding pKi = 7.0 7.0 -512 4
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
CHEMBL428666 212314 None 4 Rat Binding pKi = 7.0 7.0 -512 4
Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cellsAbility to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](Cc1ccc(OS(=O)(=O)O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2003.11.001
10509945 89382 None 0 Rat Binding pKi = 6.0 6.0 -229 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
CHEMBL2369816 89382 None 0 Rat Binding pKi = 6.0 6.0 -229 2
Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligandBinding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand
ChEMBL 896 26 9 9 2.1 CCCC[C@H](NC(=O)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)N(C)[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm990252e
44345044 111062 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 643 7 1 8 5.9 CC(=O)N1[C@H](C(=O)NCC2N=NN=N2)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL326293 111062 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 643 7 1 8 5.9 CC(=O)N1[C@H](C(=O)NCC2N=NN=N2)CC(=O)c2ccccc2N(Cc2ccccc2Cl)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
15513853 113343 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
CHEMBL331719 113343 None 0 Mouse Binding pKi = 7.0 7.0 - 1
Displacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenatesDisplacement of binding of [125I]CCK-8S to Cholecystokinin type B receptor in mouse cerebral cortex homogenates
ChEMBL 603 7 2 5 4.3 CC(=O)N1[C@H](C(=O)NCC(=O)O)CC(=O)c2ccccc2N(Cc2ccccc2F)C(=O)[C@H]1CC12CC3CC(CC(C3)C1)C2 10.1021/jm000960w
15755202 115415 None 0 Mouse Binding pKi = 6.0 6.0 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)N[C@@H](CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
CHEMBL3350356 115415 None 0 Mouse Binding pKi = 6.0 6.0 - 1
Cholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouseCholecystokinin type B receptor binding assay performed on homogenized cerebral cortex from male mouse
ChEMBL 600 12 5 5 4.5 O=C(O)CCC(=O)N[C@@H](CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC1C2CC3CC(C2)CC1C3)c1ccccc1 10.1021/jm00087a011
10793451 96515 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
CHEMBL262679 96515 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 585 8 3 5 5.2 C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)N1C[C@@H](Oc2ccccc2)C[C@@H]1C(=O)O 10.1021/jm970439a
10253387 207777 None 0 Human Binding pKi = 6.0 6.0 - 1
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 453 7 4 4 3.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(=O)O 10.1021/jm00072a005
CHEMBL96036 207777 None 0 Human Binding pKi = 6.0 6.0 - 1
Tested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortexTested for inhibition of [3H]pCCK-8 specific binding to cholecystokinin type B receptor in guinea pig brain cortex
ChEMBL 453 7 4 4 3.2 CC(Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NCC(=O)O 10.1021/jm00072a005
10628765 14250 None 0 Human Binding pKi = 6 6.0 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 734 23 7 7 2.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCC(=O)O 10.1021/jm0000416
CHEMBL119960 14250 None 0 Human Binding pKi = 6 6.0 - 1
Binding affinity against cholecystokinin type B receptor on guinea pig cortex.Binding affinity against cholecystokinin type B receptor on guinea pig cortex.
ChEMBL 734 23 7 7 2.4 CCCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)N(C)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCCCCC(=O)O 10.1021/jm0000416
10531 1419 None 21 Mouse Binding pIC50 = 8.3 8.3 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
121 1419 None 21 Mouse Binding pIC50 = 8.3 8.3 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
888 1419 None 21 Mouse Binding pIC50 = 8.3 8.3 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
CHEMBL1732 1419 None 21 Mouse Binding pIC50 = 8.3 8.3 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
DB00320 1419 None 21 Mouse Binding pIC50 = 8.3 8.3 - 24
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O None
11954224 215951 None 0 Mouse Binding pIC50 = 8.3 8.3 - 60
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
3251 215951 None 0 Mouse Binding pIC50 = 8.3 8.3 - 60
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
CHEMBL1982133 215951 None 0 Mouse Binding pIC50 = 8.3 8.3 - 60
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
DB00696 215951 None 0 Mouse Binding pIC50 = 8.3 8.3 - 60
Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranesConcentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes
Drug Central 581 4 3 6 2.0 CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C None
9853654 22787 None 41 Rat Binding pIC50 = 8.1 8.1 - 2
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 22787 None 41 Rat Binding pIC50 = 8.1 8.1 - 2
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortexInhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
9853654 22787 None 41 Mouse Binding pIC50 = 8.0 8.0 -31 2
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 22787 None 41 Mouse Binding pIC50 = 8.0 8.0 -31 2
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
4627 821 None 50 Mouse Binding pIC50 = 8.0 8.0 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
864 821 None 50 Mouse Binding pIC50 = 8.0 8.0 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
9833444 821 None 50 Mouse Binding pIC50 = 8.0 8.0 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
CHEMBL1121 821 None 50 Mouse Binding pIC50 = 8.0 8.0 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
DB09142 821 None 50 Mouse Binding pIC50 = 8.0 8.0 - 5
Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortexEvaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex
Drug Central None None None None None
104929 2217 None 9 Human Binding pKd = 8.4 8.4 51 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
3477 2217 None 9 Human Binding pKd = 8.4 8.4 51 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
879 2217 None 9 Human Binding pKd = 8.4 8.4 51 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
CHEMBL289498 2217 None 9 Human Binding pKd = 8.4 8.4 51 3
UnclassifiedUnclassified
Guide to Pharmacology 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 11738246
4627 821 125I-CCK-8 50 Rat Binding pKi = 10 10.0 1 5
NoneNone
PDSP KiDatabase None None None None None
864 821 125I-CCK-8 50 Rat Binding pKi = 10 10.0 1 5
NoneNone
PDSP KiDatabase None None None None None
9833444 821 125I-CCK-8 50 Rat Binding pKi = 10 10.0 1 5
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 821 125I-CCK-8 50 Rat Binding pKi = 10 10.0 1 5
NoneNone
PDSP KiDatabase None None None None None
DB09142 821 125I-CCK-8 50 Rat Binding pKi = 10 10.0 1 5
NoneNone
PDSP KiDatabase None None None None None
443375 207604 125I-BH-CCK-8 45 Mouse Binding pKi = 10 10.0 2 5
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
CHEMBL9506 207604 125I-BH-CCK-8 45 Mouse Binding pKi = 10 10.0 2 5
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
146158392 216246 125I-BH-CCK-8 0 Mouse Binding pKi = 10 10.0 - 1
NoneNone
PDSP KiDatabase 1079 31 14 15 -0.6 CSCCC(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CC(=O)O)N.N None
443375 207604 3H-pCCK8 45 Rat Binding pKi = 9.5 9.5 -389 5
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
CHEMBL9506 207604 3H-pCCK8 45 Rat Binding pKi = 9.5 9.5 -389 5
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c2ccccc2)c2ccccc21 None
3476 1399 125I-CCK 9 Rat Binding pKi = 9.5 9.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
59751 1399 125I-CCK 9 Rat Binding pKi = 9.5 9.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
878 1399 125I-CCK 9 Rat Binding pKi = 9.5 9.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL39263 1399 125I-CCK 9 Rat Binding pKi = 9.5 9.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
4627 821 125I-CCK-8 50 Rat Binding pKi = 9.5 9.5 1 5
NoneNone
PDSP KiDatabase None None None None None
864 821 125I-CCK-8 50 Rat Binding pKi = 9.5 9.5 1 5
NoneNone
PDSP KiDatabase None None None None None
9833444 821 125I-CCK-8 50 Rat Binding pKi = 9.5 9.5 1 5
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 821 125I-CCK-8 50 Rat Binding pKi = 9.5 9.5 1 5
NoneNone
PDSP KiDatabase None None None None None
DB09142 821 125I-CCK-8 50 Rat Binding pKi = 9.5 9.5 1 5
NoneNone
PDSP KiDatabase None None None None None
None 216244 125I-CCK-8 0 Rat Binding pKi = 9.4 9.4 - 1
NoneNone
PDSP KiDatabase 438 3 2 3 3.8 C1CN2C(=O)C(N=C(C3=C2C1=CC=C3)C4=CC=CC=C4F)NC(=O)C5=CC6=CC=CC=C6N5 None
3476 1399 125I-CCK-8 9 Rat Binding pKi = 9.4 9.4 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
59751 1399 125I-CCK-8 9 Rat Binding pKi = 9.4 9.4 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
878 1399 125I-CCK-8 9 Rat Binding pKi = 9.4 9.4 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL39263 1399 125I-CCK-8 9 Rat Binding pKi = 9.4 9.4 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
4627 821 125I-CCK-8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
864 821 125I-CCK-8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
9833444 821 125I-CCK-8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 821 125I-CCK-8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
DB09142 821 125I-CCK-8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
4627 821 3H-pCCK8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
864 821 3H-pCCK8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
9833444 821 3H-pCCK8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 821 3H-pCCK8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
DB09142 821 3H-pCCK8 50 Rat Binding pKi = 9.3 9.3 1 5
NoneNone
PDSP KiDatabase None None None None None
122077 2320 125I-CCK 51 Rat Binding pKi = 9.2 9.2 - 1
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
890 2320 125I-CCK 51 Rat Binding pKi = 9.2 9.2 - 1
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
CHEMBL249973 2320 125I-CCK 51 Rat Binding pKi = 9.2 9.2 - 1
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
DB04867 2320 125I-CCK 51 Rat Binding pKi = 9.2 9.2 - 1
NoneNone
PDSP KiDatabase 411 5 2 5 4.8 OC(=O)Cn1c(cc2c1cccc2)C(=O)Nc1scc(n1)c1ccccc1Cl None
4627 821 125I-BH-CCK-8 50 Human Binding pKi = 8.9 8.9 -1 5
NoneNone
PDSP KiDatabase None None None None None
864 821 125I-BH-CCK-8 50 Human Binding pKi = 8.9 8.9 -1 5
NoneNone
PDSP KiDatabase None None None None None
9833444 821 125I-BH-CCK-8 50 Human Binding pKi = 8.9 8.9 -1 5
NoneNone
PDSP KiDatabase None None None None None
CHEMBL1121 821 125I-BH-CCK-8 50 Human Binding pKi = 8.9 8.9 -1 5
NoneNone
PDSP KiDatabase None None None None None
DB09142 821 125I-BH-CCK-8 50 Human Binding pKi = 8.9 8.9 -1 5
NoneNone
PDSP KiDatabase None None None None None
16129670 814 125I-CCK 0 Rat Binding pKi = 8.8 8.8 -3 2
NoneNone
PDSP KiDatabase None None None None None
860 814 125I-CCK 0 Rat Binding pKi = 8.8 8.8 -3 2
NoneNone
PDSP KiDatabase None None None None None
91898395 814 125I-CCK 0 Rat Binding pKi = 8.8 8.8 -3 2
NoneNone
PDSP KiDatabase None None None None None
135398737 957 3H-CCK8 93 Rat Binding pKi = 6 6.0 -416 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 957 3H-CCK8 93 Rat Binding pKi = 6 6.0 -416 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 957 3H-CCK8 93 Rat Binding pKi = 6 6.0 -416 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 957 3H-CCK8 93 Rat Binding pKi = 6 6.0 -416 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 957 3H-CCK8 93 Rat Binding pKi = 6 6.0 -416 91
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
202 1507 UNDEFINED 77 Mouse Binding pKi = 6 6.0 -9 33
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 1507 UNDEFINED 77 Mouse Binding pKi = 6 6.0 -9 33
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 1507 UNDEFINED 77 Mouse Binding pKi = 6 6.0 -9 33
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 1507 UNDEFINED 77 Mouse Binding pKi = 6 6.0 -9 33
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 1507 UNDEFINED 77 Mouse Binding pKi = 6 6.0 -9 33
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
1222 1662 3H-CCK8 49 Rat Binding pKi = 6 6.0 -1659 33
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3396 1662 3H-CCK8 49 Rat Binding pKi = 6 6.0 -1659 33
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
85 1662 3H-CCK8 49 Rat Binding pKi = 6 6.0 -1659 33
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL46516 1662 3H-CCK8 49 Rat Binding pKi = 6 6.0 -1659 33
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
DB04842 1662 3H-CCK8 49 Rat Binding pKi = 6 6.0 -1659 33
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
1353 1909 3H-CCK8 93 Rat Binding pKi = 6 6.0 -691 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 1909 3H-CCK8 93 Rat Binding pKi = 6 6.0 -691 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 1909 3H-CCK8 93 Rat Binding pKi = 6 6.0 -691 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 1909 3H-CCK8 93 Rat Binding pKi = 6 6.0 -691 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 1909 3H-CCK8 93 Rat Binding pKi = 6 6.0 -691 86
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
135398745 2912 3H-CCK8 112 Rat Binding pKi = 6 6.0 -512 66
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 2912 3H-CCK8 112 Rat Binding pKi = 6 6.0 -512 66
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 2912 3H-CCK8 112 Rat Binding pKi = 6 6.0 -512 66
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 2912 3H-CCK8 112 Rat Binding pKi = 6 6.0 -512 66
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
2181 3126 3H-CCK8 46 Rat Binding pKi = 6 6.0 -831 35
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 3126 3H-CCK8 46 Rat Binding pKi = 6 6.0 -831 35
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 3126 3H-CCK8 46 Rat Binding pKi = 6 6.0 -831 35
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 3126 3H-CCK8 46 Rat Binding pKi = 6 6.0 -831 35
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 3126 3H-CCK8 46 Rat Binding pKi = 6 6.0 -831 35
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
2337 3254 3H-CCK8 77 Rat Binding pKi = 6 6.0 -112 63
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 3254 3H-CCK8 77 Rat Binding pKi = 6 6.0 -112 63
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 3254 3H-CCK8 77 Rat Binding pKi = 6 6.0 -112 63
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 3254 3H-CCK8 77 Rat Binding pKi = 6 6.0 -112 63
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 3254 3H-CCK8 77 Rat Binding pKi = 6 6.0 -112 63
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2389 3329 3H-CCK8 118 Rat Binding pKi = 6 6.0 -2691 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 3329 3H-CCK8 118 Rat Binding pKi = 6 6.0 -2691 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 3329 3H-CCK8 118 Rat Binding pKi = 6 6.0 -2691 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 3329 3H-CCK8 118 Rat Binding pKi = 6 6.0 -2691 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 3329 3H-CCK8 118 Rat Binding pKi = 6 6.0 -2691 67
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2435 3588 3H-CCK8 83 Rat Binding pKi = 6 6.0 -1949 49
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 3588 3H-CCK8 83 Rat Binding pKi = 6 6.0 -1949 49
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 3588 3H-CCK8 83 Rat Binding pKi = 6 6.0 -1949 49
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 3588 3H-CCK8 83 Rat Binding pKi = 6 6.0 -1949 49
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 3588 3H-CCK8 83 Rat Binding pKi = 6 6.0 -1949 49
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
2865 4141 3H-CCK8 73 Rat Binding pKi = 6 6.0 -2041 54
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 4141 3H-CCK8 73 Rat Binding pKi = 6 6.0 -2041 54
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 4141 3H-CCK8 73 Rat Binding pKi = 6 6.0 -2041 54
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 4141 3H-CCK8 73 Rat Binding pKi = 6 6.0 -2041 54
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 4141 3H-CCK8 73 Rat Binding pKi = 6 6.0 -2041 54
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
103 4151 3H-CCK8 61 Rat Binding pKi = 6 6.0 -831 54
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 4151 3H-CCK8 61 Rat Binding pKi = 6 6.0 -831 54
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 4151 3H-CCK8 61 Rat Binding pKi = 6 6.0 -831 54
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 4151 3H-CCK8 61 Rat Binding pKi = 6 6.0 -831 54
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 4151 3H-CCK8 61 Rat Binding pKi = 6 6.0 -831 54
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
115237 55583 3H-CCK8 119 Rat Binding pKi = 6 6.0 -4265 55
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 55583 3H-CCK8 119 Rat Binding pKi = 6 6.0 -4265 55
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
DB01267 55583 3H-CCK8 119 Rat Binding pKi = 6 6.0 -4265 55
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
3036780 107529 3H-CCK8 20 Rat Binding pKi = 6 6.0 -5888 54
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
46780481 107529 3H-CCK8 20 Rat Binding pKi = 6 6.0 -5888 54
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 107529 3H-CCK8 20 Rat Binding pKi = 6 6.0 -5888 54
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 107529 3H-CCK8 20 Rat Binding pKi = 6 6.0 -5888 54
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 107529 3H-CCK8 20 Rat Binding pKi = 6 6.0 -5888 54
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL504548 107529 3H-CCK8 20 Rat Binding pKi = 6 6.0 -5888 54
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
DB06216 107529 3H-CCK8 20 Rat Binding pKi = 6 6.0 -5888 54
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
5656 203064 UNDEFINED 87 Mouse Binding pKi = 6 6.0 -7 43
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 203064 UNDEFINED 87 Mouse Binding pKi = 6 6.0 -7 43
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 203125 UNDEFINED 52 Mouse Binding pKi = 6 6.0 -1 30
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 203125 UNDEFINED 52 Mouse Binding pKi = 6 6.0 -1 30
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 217330 3H-Devazepide 0 Human Binding pKi = 6 6.0 -2 37
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
1192 147 3H-CCK8 47 Rat Binding pKi = 5 5.0 -162 17
NoneNone
PDSP KiDatabase 311 2 3 5 0.5 NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N None
1794 147 3H-CCK8 47 Rat Binding pKi = 5 5.0 -162 17
NoneNone
PDSP KiDatabase 311 2 3 5 0.5 NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N None
CHEMBL501701 147 3H-CCK8 47 Rat Binding pKi = 5 5.0 -162 17
NoneNone
PDSP KiDatabase 311 2 3 5 0.5 NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N None
119376 1839 3H-L364718 48 Rat Binding pKi = 5 5.0 -54954 27
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
247 1839 3H-L364718 48 Rat Binding pKi = 5 5.0 -54954 27
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
CHEMBL33884 1839 3H-L364718 48 Rat Binding pKi = 5 5.0 -54954 27
NoneNone
PDSP KiDatabase 393 7 1 6 1.6 O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C None
3294 2004 3H-L354718 111 Human Binding pKi = 5 5.0 -323 45
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 2004 3H-L354718 111 Human Binding pKi = 5 5.0 -323 45
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 2004 3H-L354718 111 Human Binding pKi = 5 5.0 -323 45
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 2004 3H-L354718 111 Human Binding pKi = 5 5.0 -323 45
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 2004 3H-L354718 111 Human Binding pKi = 5 5.0 -323 45
NoneNone
PDSP KiDatabase 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
1614 2347 125I-CCK-8 67 Rat Binding pKi = 5 5.0 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
60182 2347 125I-CCK-8 67 Rat Binding pKi = 5 5.0 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
892 2347 125I-CCK-8 67 Rat Binding pKi = 5 5.0 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
CHEMBL206025 2347 125I-CCK-8 67 Rat Binding pKi = 5 5.0 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
243 3200 3H-CCK8 91 Rat Binding pKi = 5 5.0 -1096 34
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 3200 3H-CCK8 91 Rat Binding pKi = 5 5.0 -1096 34
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 3200 3H-CCK8 91 Rat Binding pKi = 5 5.0 -1096 34
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 3200 3H-CCK8 91 Rat Binding pKi = 5 5.0 -1096 34
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 3200 3H-CCK8 91 Rat Binding pKi = 5 5.0 -1096 34
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
108107 79942 3H-CCK8 38 Rat Binding pKi = 5 5.0 -15 16
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
156592250 79942 3H-CCK8 38 Rat Binding pKi = 5 5.0 -15 16
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
CHEMBL1256878 79942 3H-CCK8 38 Rat Binding pKi = 5 5.0 -15 16
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
CHEMBL212579 79942 3H-CCK8 38 Rat Binding pKi = 5 5.0 -15 16
NoneNone
PDSP KiDatabase 319 3 4 5 0.5 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1 None
3025067 99380 3H-CCK8 64 Rat Binding pKi = 5 5.0 -512 15
NoneNone
PDSP KiDatabase 220 1 1 4 0.9 c1cc2c(c(N3CCNCC3)c1)OCCO2 None
65853 99380 3H-CCK8 64 Rat Binding pKi = 5 5.0 -512 15
NoneNone
PDSP KiDatabase 220 1 1 4 0.9 c1cc2c(c(N3CCNCC3)c1)OCCO2 None
CHEMBL282614 99380 3H-CCK8 64 Rat Binding pKi = 5 5.0 -512 15
NoneNone
PDSP KiDatabase 220 1 1 4 0.9 c1cc2c(c(N3CCNCC3)c1)OCCO2 None
44208932 140705 UNDEFINED 7 Human Binding pKi = 5 5.0 -89125 37
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 140705 UNDEFINED 7 Human Binding pKi = 5 5.0 -89125 37
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
4595 176713 3H-CCK8 106 Rat Binding pKi = 5 5.0 -6 15
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
CHEMBL46 176713 3H-CCK8 106 Rat Binding pKi = 5 5.0 -6 15
NoneNone
PDSP KiDatabase 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
1973 203481 3H-Devazepide 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL1394464 203481 3H-Devazepide 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
CHEMBL66089 203481 3H-Devazepide 15 Rat Binding pKi = 5 5.0 -3 37
NoneNone
PDSP KiDatabase 462 3 1 7 3.9 Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12 None
16231 207507 3H-CCK8 57 Rat Binding pKi = 5 5.0 -7 17
NoneNone
PDSP KiDatabase 229 1 5 6 -1.1 N=C(N)NC(=O)c1nc(Cl)c(N)nc1N None
CHEMBL945 207507 3H-CCK8 57 Rat Binding pKi = 5 5.0 -7 17
NoneNone
PDSP KiDatabase 229 1 5 6 -1.1 N=C(N)NC(=O)c1nc(Cl)c(N)nc1N None
None 216491 3H-CCK8 0 Rat Binding pKi = 5 5.0 -10471285 17
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
10478703 119910 125I-BH-CCK-85 1 Rat Binding pKi = 5.8 5.8 - 1
NoneNone
PDSP KiDatabase 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 None
CHEMBL349291 119910 125I-BH-CCK-85 1 Rat Binding pKi = 5.8 5.8 - 1
NoneNone
PDSP KiDatabase 445 2 2 4 4.0 Cc1cccc(NC(=O)NC2N=C(N3CC4CCC(CC4)C3)c3ccccc3N(C)C2=O)c1 None
104929 2217 125I-BH-CCK-8 9 Mouse Binding pKi = 6.6 6.6 -51 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
3477 2217 125I-BH-CCK-8 9 Mouse Binding pKi = 6.6 6.6 -51 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
879 2217 125I-BH-CCK-8 9 Mouse Binding pKi = 6.6 6.6 -51 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL289498 2217 125I-BH-CCK-8 9 Mouse Binding pKi = 6.6 6.6 -51 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
1614 2347 125I-CCK-8 67 Rat Binding pKi = 6.6 6.6 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
60182 2347 125I-CCK-8 67 Rat Binding pKi = 6.6 6.6 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
892 2347 125I-CCK-8 67 Rat Binding pKi = 6.6 6.6 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
CHEMBL206025 2347 125I-CCK-8 67 Rat Binding pKi = 6.6 6.6 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
3476 1399 125I-CCK-8 9 Rat Binding pKi = 6.5 6.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
59751 1399 125I-CCK-8 9 Rat Binding pKi = 6.5 6.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
878 1399 125I-CCK-8 9 Rat Binding pKi = 6.5 6.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL39263 1399 125I-CCK-8 9 Rat Binding pKi = 6.5 6.5 -2 3
NoneNone
PDSP KiDatabase 408 3 2 3 3.7 O=C(c1cc2c([nH]1)cccc2)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
1614 2347 125I-CCK-8 67 Rat Binding pKi = 6.5 6.5 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
60182 2347 125I-CCK-8 67 Rat Binding pKi = 6.5 6.5 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
892 2347 125I-CCK-8 67 Rat Binding pKi = 6.5 6.5 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
CHEMBL206025 2347 125I-CCK-8 67 Rat Binding pKi = 6.5 6.5 - 1
NoneNone
PDSP KiDatabase 460 14 2 4 4.0 CCCCCN(C(=O)C(NC(=O)c1ccc(c(c1)Cl)Cl)CCC(=O)O)CCCOC None
None 216245 UNDEFINED 0 Rat Binding pKi = 5.4 5.4 - 1
NoneNone
PDSP KiDatabase 809 18 11 11 1.5 CC(CC1=CNC2=CC=CC=C21)(C(=O)NCC(C3=CC=CC=C3)NC(=O)CCC(=O)O)NC(=O)OC4C5CC6CC(C5)CC4C6.CNCC(C(C(C(CO)O)O)O)O None
4595 176713 None 106 Rat Binding pKi = 8.2 8.2 -6 15
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
Drug Central 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
CHEMBL46 176713 None 106 Rat Binding pKi = 8.2 8.2 -6 15
The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.The binding affinity was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
Drug Central 293 2 0 4 3.1 Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O None
9853654 22787 125I-BH-CCK-8 41 Mouse Binding pKi = 6.2 6.2 -31 2
NoneNone
PDSP KiDatabase 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 22787 125I-BH-CCK-8 41 Mouse Binding pKi = 6.2 6.2 -31 2
NoneNone
PDSP KiDatabase 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
9853654 22787 None 41 Human Binding pKi = 8.1 8.1 31 2
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
CHEMBL1328 22787 None 41 Human Binding pKi = 8.1 8.1 31 2
Inhibition of binding of [125I]-PD 142308 to CCK-B receptor was determinedInhibition of binding of [125I]-PD 142308 to CCK-B receptor was determined
Drug Central 767 20 8 9 1.5 CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O None
104929 2217 125I-BH-CCK-85 9 Rat Binding pKi = 6.1 6.1 -165 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
3477 2217 125I-BH-CCK-85 9 Rat Binding pKi = 6.1 6.1 -165 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
879 2217 125I-BH-CCK-85 9 Rat Binding pKi = 6.1 6.1 -165 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
CHEMBL289498 2217 125I-BH-CCK-85 9 Rat Binding pKi = 6.1 6.1 -165 3
NoneNone
PDSP KiDatabase 398 3 2 3 4.0 Cc1cccc(c1)NC(=O)NC1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2 None
4627 821 None 50 Rat Binding pKi = 8.0 8.0 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
864 821 None 50 Rat Binding pKi = 8.0 8.0 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
9833444 821 None 50 Rat Binding pKi = 8.0 8.0 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
CHEMBL1121 821 None 50 Rat Binding pKi = 8.0 8.0 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
DB09142 821 None 50 Rat Binding pKi = 8.0 8.0 1 5
Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomesBinding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes
Drug Central None None None None None
4627 821 None 50 Human Binding pKi = 8.0 8.0 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
864 821 None 50 Human Binding pKi = 8.0 8.0 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
9833444 821 None 50 Human Binding pKi = 8.0 8.0 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
CHEMBL1121 821 None 50 Human Binding pKi = 8.0 8.0 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
DB09142 821 None 50 Human Binding pKi = 8.0 8.0 -1 5
Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brainTested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain
Drug Central None None None None None
5311400 3291 None 1 Rat Binding pKi = 9.1 9.1 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
900 3291 None 1 Rat Binding pKi = 9.1 9.1 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
CHEMBL262197 3291 None 1 Rat Binding pKi = 9.1 9.1 -2 3
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
3294 2004 None 111 Human Binding pKi None 8.3 8.3 -323 45
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
71360 2004 None 111 Human Binding pKi None 8.3 8.3 -323 45
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
87 2004 None 111 Human Binding pKi None 8.3 8.3 -323 45
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
CHEMBL14376 2004 None 111 Human Binding pKi None 8.3 8.3 -323 45
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
DB04946 2004 None 111 Human Binding pKi None 8.3 8.3 -323 45
NoneNone
Drug Central 426 8 0 6 4.8 COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C None
885 3846 None 0 Rat Binding pKi None 5.7 5.7 -1584 2
UnclassifiedUnclassified
Guide to Pharmacology 619 10 3 6 5.1 O=C([C@@H](NC(=O)c1cc2c([nH]1)cccc2)CSc1ncccc1C(=O)O)N1CCN(CC1)C(c1ccccc1)c1ccccc1 8730754
9873836 3846 None 0 Rat Binding pKi None 5.7 5.7 -1584 2
UnclassifiedUnclassified
Guide to Pharmacology 619 10 3 6 5.1 O=C([C@@H](NC(=O)c1cc2c([nH]1)cccc2)CSc1ncccc1C(=O)O)N1CCN(CC1)C(c1ccccc1)c1ccccc1 8730754
859 472 None 0 Rat Binding pKi None 6.6 6.6 -7943 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9476993
896 590 None 0 Rat Binding pKi None 7.4 7.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1614411
906 3378 None 0 Rat Binding pKi None 8 8.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 474 9 3 4 3.1 O=C(Nc1cccc(c1)CC(=O)O)NCC(=O)N(c1ccccc1)CC(=O)N(c1ccccc1)C 7813588
9847721 3378 None 0 Rat Binding pKi None 8 8.0 - 1
UnclassifiedUnclassified
Guide to Pharmacology 474 9 3 4 3.1 O=C(Nc1cccc(c1)CC(=O)O)NCC(=O)N(c1ccccc1)CC(=O)N(c1ccccc1)C 7813588
901 306 None 0 Human Binding pKi None 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 11 3 5 5.1 CCOC(CN1c2ccccc2[C@@](C1=O)(CC(=O)Nc1ccc(cc1)C)NC(=O)Nc1ccc(cc1)C)OCC 11738246
9807431 306 None 0 Human Binding pKi None 8.3 8.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 11 3 5 5.1 CCOC(CN1c2ccccc2[C@@](C1=O)(CC(=O)Nc1ccc(cc1)C)NC(=O)Nc1ccc(cc1)C)OCC 11738246
895 589 None 0 Rat Binding pKi None 8.6 8.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14698161
907 4128 None 0 Human Binding pKi None 9.3 9.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 520 6 3 5 4.7 O=C(N[C@@H]1CN(C2CCCCC2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2)Nc1cccc(c1)C(=O)O 17901954
9872609 4128 None 0 Human Binding pKi None 9.3 9.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 520 6 3 5 4.7 O=C(N[C@@H]1CN(C2CCCCC2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2)Nc1cccc(c1)C(=O)O 17901954
CHEMBL4303633 4128 None 0 Human Binding pKi None 9.3 9.3 - 1
UnclassifiedUnclassified
Guide to Pharmacology 520 6 3 5 4.7 O=C(N[C@@H]1CN(C2CCCCC2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2)Nc1cccc(c1)C(=O)O 17901954
887 4108 None 33 Human Binding pKi None 9.6 9.6 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246
9870520 4108 None 33 Human Binding pKi None 9.6 9.6 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246
CHEMBL324547 4108 None 33 Human Binding pKi None 9.6 9.6 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246
DB12355 4108 None 33 Human Binding pKi None 9.6 9.6 -1 4
UnclassifiedUnclassified
Guide to Pharmacology 498 6 3 6 4.1 CNc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccn2)c2c(N(C1=O)CC(=O)C(C)(C)C)cccc2 11738246