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Ligand source activities (1 row/activity)

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

C3a receptor agonist	770	None	35	Human	Binding	pIC50	=	-	6.10	-	1	IC50 determined in a radioligand displacement assay; displacing [¹²⁵I]C3a from hC3a receptor expressed in HMC1 cells co-expressing aequorin.	Guide to Pharmacology	433.3	7	1	3	4.49	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCCCC1	https://pubmed.ncbi.nlm.nih.gov/17459702
C3a receptor agonist	770	None	35	Human	Binding	IC50	=	794.33	6.10	-	1	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	433.3	7	1	3	4.49	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCCCC1	https://dx.doi.org/10.1016/j.bmcl.2007.04.023
C3a receptor agonist	770	None	35	Human	Binding	IC50	=	5011.87	5.30	-	1	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	433.3	7	1	3	4.49	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCCCC1	https://dx.doi.org/10.1016/j.bmcl.2007.04.023
C3a receptor agonist	770	None	35	Human	Binding	IC50	=	316.23	6.50	-	1	Displacement of [125I]C3a from human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	433.3	7	1	3	4.49	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCCCC1	https://dx.doi.org/10.1016/j.bmcl.2007.04.023
CHEMBL1169838	210996	None	0	Human	Binding	IC50	=	1600.00	5.80	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1169838	210996	None	0	Human	Binding	IC50	=	1584.89	5.80	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170025	210997	None	0	Human	Binding	IC50	=	250.00	6.60	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170025	210997	None	0	Human	Binding	IC50	=	251.19	6.60	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170026	210998	None	0	Human	Binding	IC50	=	13.00	7.89	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170026	210998	None	0	Human	Binding	IC50	=	12.59	7.90	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170027	210999	None	0	Human	Binding	IC50	=	740.00	6.13	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170027	210999	None	0	Human	Binding	IC50	=	794.33	6.10	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170029	211001	None	0	Human	Binding	IC50	=	140.00	6.85	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170029	211001	None	0	Human	Binding	IC50	=	125.89	6.90	-	2	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170030	211002	None	9	Human	Binding	IC50	=	5900.00	5.23	-	1	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170030	211002	None	9	Human	Binding	IC50	=	6309.57	5.20	-	1	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170031	211003	None	0	Human	Binding	IC50	=	6300.00	5.20	-	1	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170031	211003	None	0	Human	Binding	IC50	=	6309.57	5.20	-	1	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170033	211004	None	0	Human	Binding	IC50	=	27000.00	4.57	-	1	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170033	211004	None	0	Human	Binding	IC50	=	31622.78	4.50	-	1	Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation counting	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705

Showing 1 to 20 of 199 entries

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	Ligands				Receptor	Activity									Chemical information
	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ligands				Receptor	Activity									Chemical information
Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI

Ac-RHYPLWR	267	None	0	Human	Functional	pEC50	=	-	5.96	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/25446428
C3a	769	None	0	Human	Functional	pEC50	=	-	7.30	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/20527893
C3a	769	None	0	Human	Functional	pEC50	=	-	9.62	-	1	In a calcium mobilisation assay using RBL-2H3 cells stably expressing the hC3aR.	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9476119
C3a receptor agonist	770	None	35	Human	Functional	EC50	=	1995.26	5.70	-	1	Agonist activity at human C3a receptor expressed in HMC1 cells co-expressing aequorin	ChEMBL	433.3	7	1	3	4.49	O=C(NC1CCN(C(=O)CCc2cccnc2)CC1)C(c1ccccc1)C1CCCCC1	https://dx.doi.org/10.1016/j.bmcl.2007.04.023
casoxin C	805	None	0	Human	Functional	pIC50	=	-	4.40	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/9145417
casoxin C	805	None	0	Human	Functional	pIC50	=	-	4.40	-	1	Unclassified	Guide to Pharmacology	-	-	-	-	-	-	https://pubmed.ncbi.nlm.nih.gov/26297549
CHEMBL1169603	210995	None	0	Human	Functional	EC50	=	780.00	6.11	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1169603	210995	None	0	Human	Functional	EC50	=	794.33	6.10	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1169838	210996	None	0	Human	Functional	EC50	=	24000.00	4.62	-6	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1169838	210996	None	0	Human	Functional	EC50	=	25118.86	4.60	-6	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170025	210997	None	0	Human	Functional	EC50	=	1800.00	5.75	-1	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170025	210997	None	0	Human	Functional	EC50	=	1584.89	5.80	-1	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	-	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170026	210998	None	0	Human	Functional	EC50	=	130.00	6.89	48	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170026	210998	None	0	Human	Functional	EC50	=	125.89	6.90	48	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170027	210999	None	0	Human	Functional	EC50	=	1400.00	5.85	30	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170027	210999	None	0	Human	Functional	EC50	=	1258.93	5.90	30	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170028	211000	None	0	Human	Functional	EC50	=	5700.00	5.24	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170028	211000	None	0	Human	Functional	IC50	=	6309.57	5.20	-	1	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170029	211001	None	0	Human	Functional	EC50	=	220.00	6.66	29	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705
CHEMBL1170029	211001	None	0	Human	Functional	EC50	=	199.53	6.70	29	2	Agonist activity at human C3a receptor in human U937 cells assessed as induction of intracellular calcium release	ChEMBL	-	-	-	-	-	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	https://dx.doi.org/10.1021/jm1003705

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Ligand source activities (1 row/activity)