H4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JXV

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-024-46840-5

PUBLICATION DATE

March 20, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

clozapine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

CCL16, histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 123 - G.H5 I 343 G.H5.15
Hydrophobic TM6 V 293 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 V 293 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 112 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 123 - G.S3 L 194 G.S3.01
Polar H8 H 362 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 H 362 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 H 362 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 201 5x65 G.H5 K 345 G.H5.17
Van-der-waals TM5 L 201 5x65 G.H5 K 345 G.H5.17
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic H8 H 362 8x47 G.H5 C 351 G.H5.23
Polar ICL2 R 123 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 R 123 - G.S1 E 33 G.S1.01
Hydrophobic TM5 I 197 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 197 5x61 G.H5 L 353 G.H5.25
Polar ICL2 T 124 - G.s2s3 D 193 G.s2s3.02
Polar TM3 R 112 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 116 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 201 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 201 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 120 - G.H5 F 336 G.H5.08
Hydrophobic TM6 L 301 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 119 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 119 - G.H5 I 344 G.H5.16
Hydrophobic TM3 V 116 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 304 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 300 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 300 6x32 G.H5 F 354 G.H5.26
Polar H8 K 363 8x48 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 301 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 301 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM5 I 197 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 126 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 124 - G.hns1 R 32 G.hns1.03
Polar ICL2 R 123 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 123 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 123 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 123 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 A 119 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 119 - G.H5 I 343 G.H5.15
Hydrophobic TM3 V 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 348 G.H5.20
Polar TM3 S 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 347 G.H5.19