ADGRL3 - G12

GPCR CLASS (FAMILY)

Class B2 (Adhesion)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7X10

RESOLUTION

2.9 Å

REFERENCE

10.1016/J.MOLCEL.2022.10.009

PUBLICATION DATE

Nov. 9, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 1040 - G.H5 K 363 G.H5.12
Van-der-waals ICL2 V 1040 - G.H5 K 363 G.H5.12
Hydrophobic ICL2 F 1041 - G.S3 I 217 G.S3.01
Hydrophobic TM3 L 1033 3x54 G.H5 I 374 G.H5.23
Hydrophobic ICL2 F 1041 - G.H5 K 363 G.H5.12
Hydrophobic ICL2 V 1040 - G.H5 I 366 G.H5.15
Van-der-waals ICL2 V 1040 - G.H5 I 366 G.H5.15
Hydrophobic TM6 L 1150 6x45 G.H5 I 374 G.H5.23
Hydrophobic ICL2 S 1043 - G.hns1 R 39 G.hns1.03
Hydrophobic TM3 L 1037 3x58 G.H5 L 371 G.H5.20
Van-der-waals TM3 L 1037 3x58 G.H5 L 371 G.H5.20
Polar TM6 G 1146 6x41 G.H5 M 375 G.H5.24
Hydrophobic TM6 G 1146 6x41 G.H5 M 375 G.H5.24
Ionic ICL2 E 1042 - G.HN R 38 G.HN.38
Polar ICL2 E 1042 - G.HN R 38 G.HN.38
Hydrophobic ICL2 E 1042 - G.HN R 38 G.HN.38
Van-der-waals ICL2 E 1042 - G.HN R 38 G.HN.38
Polar TM3 M 1036 3x57 G.H5 N 370 G.H5.19
Van-der-waals TM3 M 1036 3x57 G.H5 N 370 G.H5.19
Hydrophobic TM5 M 1114 5x61 G.H5 L 371 G.H5.20
Hydrophobic ICL2 S 1046 - G.HN R 35 G.HN.52
Ionic H8 K 1197 8x49 G.H5 D 373 G.H5.22
Polar H8 K 1197 8x49 G.H5 D 373 G.H5.22
Hydrophobic H8 K 1197 8x49 G.H5 D 373 G.H5.22
Van-der-waals H8 K 1197 8x49 G.H5 D 373 G.H5.22
Ionic ICL2 E 1042 - G.HN R 35 G.HN.52
Polar ICL2 E 1042 - G.HN R 35 G.HN.52
Hydrophobic TM3 L 1037 3x58 G.H5 L 367 G.H5.16
Van-der-waals TM3 L 1037 3x58 G.H5 L 367 G.H5.16
Hydrophobic ICL2 H 1045 - G.HN R 35 G.HN.52
Hydrophobic ICL2 V 1040 - G.H5 L 367 G.H5.16
Van-der-waals ICL2 V 1040 - G.H5 L 367 G.H5.16
Ionic ICL2 E 1044 - G.hns1 R 39 G.hns1.03
Polar ICL2 E 1044 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL2 E 1044 - G.hns1 R 39 G.hns1.03
Van-der-waals ICL2 E 1044 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL2 E 1044 - G.HN R 35 G.HN.52
Van-der-waals ICL2 E 1044 - G.HN R 35 G.HN.52
Hydrophobic ICL2 F 1041 - G.H5 V 362 G.H5.11
Polar ICL2 E 1042 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL2 E 1042 - G.hns1 R 39 G.hns1.03
Hydrophobic ICL2 F 1041 - G.H5 F 359 G.H5.08
Ionic ICL3 H 1117 - G.H5 D 364 G.H5.13
Polar ICL3 H 1117 - G.H5 D 364 G.H5.13
Hydrophobic ICL3 H 1117 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 H 1117 - G.H5 D 364 G.H5.13
Hydrophobic TM3 M 1036 3x57 G.H5 I 374 G.H5.23
Hydrophobic TM5 M 1114 5x61 G.H5 L 376 G.H5.25
Van-der-waals TM5 M 1114 5x61 G.H5 L 376 G.H5.25
Polar TM6 W 1143 6x38 G.H5 L 376 G.H5.25
Hydrophobic TM6 W 1143 6x38 G.H5 L 376 G.H5.25
Van-der-waals TM6 W 1143 6x38 G.H5 L 376 G.H5.25
Hydrophobic ICL3 H 1117 - G.H5 L 367 G.H5.16
Polar TM2 R 977 2x46 G.H5 D 373 G.H5.22
Polar ICL2 S 1043 - G.HN R 35 G.HN.52
Van-der-waals ICL2 S 1043 - G.HN R 35 G.HN.52
Hydrophobic ICL2 F 1041 - G.H5 I 366 G.H5.15
Van-der-waals ICL2 F 1041 - G.H5 I 366 G.H5.15