CCK1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

May 22, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

CHEMBL216166 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

desulfated cholecystokinin-8, CCK-39, CCK-4, gastrin-17, CCK-8, CCK-33, CCK-58



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM2 N 77 2x40 G.H5 N 392 G.H5.24
Hydrophobic TM6 V 311 6x33 G.H5 V 394 G.H5.26
Hydrophobic TM3 R 139 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 393 G.H5.25
Polar TM3 R 139 3x50 G.H5 N 392 G.H5.24
Polar H8 N 374 8x47 G.H5 N 392 G.H5.24
Hydrophobic H8 N 374 8x47 G.H5 N 392 G.H5.24
Van-der-waals H8 N 374 8x47 G.H5 N 392 G.H5.24
Hydrophobic ICL2 L 147 - G.S1 L 41 G.S1.02
Hydrophobic ICL2 R 150 - G.S1 L 41 G.S1.02
Van-der-waals ICL2 R 150 - G.S1 L 41 G.S1.02
Hydrophobic ICL2 V 151 - G.hns1 R 39 G.hns1.03
Van-der-waals ICL2 V 151 - G.hns1 R 39 G.hns1.03
Hydrophobic TM6 L 315 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 315 6x37 G.H5 L 393 G.H5.25
Polar H8 R 376 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 R 376 8x49 G.H5 R 389 G.H5.21
Hydrophobic TM3 E 138 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM2 T 76 2x39 G.H5 E 390 G.H5.22
Van-der-waals TM2 T 76 2x39 G.H5 E 390 G.H5.22
Hydrophobic ICL2 P 146 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 383 G.H5.15
Ionic H8 R 376 8x49 G.H5 E 390 G.H5.22
Polar H8 R 376 8x49 G.H5 E 390 G.H5.22
Hydrophobic H8 R 376 8x49 G.H5 E 390 G.H5.22
Van-der-waals H8 R 376 8x49 G.H5 E 390 G.H5.22
Polar ICL2 R 150 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 150 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 147 - G.H5 C 379 G.H5.11
Van-der-waals TM2 L 80 2x43 G.H5 N 392 G.H5.24
Hydrophobic TM3 I 143 3x54 G.H5 N 387 G.H5.19
Hydrophobic TM4 T 154 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 147 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 147 - G.H5 I 383 G.H5.15
Polar ICL2 V 151 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 V 151 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 147 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 147 - G.H5 F 376 G.H5.08
Hydrophobic TM2 T 76 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 143 3x54 G.H5 L 393 G.H5.25
Polar TM3 A 142 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 387 G.H5.19
Polar TM2 T 74 2x37 G.H5 E 390 G.H5.22
Polar ICL2 Q 153 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Q 153 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Q 153 - G.H5 Y 391 G.H5.23
Hydrophobic TM6 V 311 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 311 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 236 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 236 5x65 G.H5 L 388 G.H5.20
Polar TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 L 384 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 L 384 G.H5.16
Hydrophobic ICL2 L 147 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 147 - G.H5 K 380 G.H5.12
Van-der-waals ICL2 L 147 - G.H5 K 380 G.H5.12
Hydrophobic ICL2 P 146 - G.H5 L 384 G.H5.16
Hydrophobic TM5 I 232 5x61 G.H5 L 393 G.H5.25