GIP receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

gastric inhibitory polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 L 184 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM6 R 280 6x40 G.H5 L 393 G.H5.25
Van-der-waals TM6 R 280 6x40 G.H5 L 393 G.H5.25
Polar TM3 L 184 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 184 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 184 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 187 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 G 188 - G.S3 V 217 G.S3.01
Ionic TM5 K 263 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 263 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 263 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 263 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 256 5x57 G.H5 L 393 G.H5.25
Polar TM2 R 108 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 108 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 108 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM3 L 184 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 184 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM3 E 176 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 176 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 260 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 187 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 V 187 - G.H5 F 376 G.H5.08
Polar TM3 L 186 3x60 G.H5 R 380 G.H5.12
Aromatic TM2 R 108 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 108 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM6 L 276 6x36 G.H5 L 393 G.H5.25
Polar TM3 L 183 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 183 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 183 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 187 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 187 - G.S3 V 217 G.S3.01
Hydrophobic TM5 I 259 5x60 G.H5 L 388 G.H5.20
Ionic H8 K 336 8x48 G.H5 E 392 G.H5.24
Polar H8 K 336 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 336 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 G 189 - G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 G 189 - G.hns1 A 39 G.hns1.03
Hydrophobic TM5 L 260 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 260 5x61 G.H5 L 393 G.H5.25
Hydrophobic H8 N 335 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 K 263 5x64 G.H5 L 394 G.H5.26
Van-der-waals TM5 K 263 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 260 5x61 G.H5 L 394 G.H5.26
Polar ICL2 S 190 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 S 190 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 R 280 6x40 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 280 6x40 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 180 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 180 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 263 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM6 F 284 6x44 G.H5 L 393 G.H5.25
Hydrophobic TM3 Y 179 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 179 3x53 G.H5 Y 391 G.H5.23
Polar TM5 K 263 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 263 5x64 G.H5 R 385 G.H5.17
Polar H8 E 337 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 E 337 8x49 G.H5 Q 390 G.H5.22
Polar TM5 K 263 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 263 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 263 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 180 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL4 I 334 - G.H5 E 392 G.H5.24
Polar ICL2 S 190 - G.hns1 A 39 G.hns1.03