mGlu4 receptor - Gi3

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7E9H

RESOLUTION

4.0 Å

REFERENCE

10.1038/S41586-021-03495-2

PUBLICATION DATE

June 23, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

29 interactions (Click to see)

LIGANDS

L-serine-O-phosphate - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

L-serine-O-phosphate, L-glutamic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 686 3x63 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 R 686 3x63 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 V 688 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 688 - G.H5 I 343 G.H5.15
Polar TM3 K 685 3x62 G.s2s3 D 193 G.s2s3.02
Polar ICL2 V 688 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 V 688 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 V 688 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL1 A 620 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 A 620 12x52 G.H5 L 353 G.H5.25
Hydrophobic ICL1 K 619 12x51 G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 619 12x51 G.H5 L 353 G.H5.25
Polar TM3 S 687 3x64 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 G 684 3x61 G.H5 I 344 G.H5.16
Van-der-waals TM3 G 684 3x61 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 688 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 V 688 - G.S1 E 33 G.S1.01
Polar TM3 K 685 3x62 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM3 F 681 3x58 G.H5 I 344 G.H5.16
Hydrophobic TM3 G 684 3x61 G.H5 I 343 G.H5.15
Van-der-waals TM3 G 684 3x61 G.H5 I 343 G.H5.15
Hydrophobic ICL2 V 688 - G.hns1 K 32 G.hns1.03
Polar ICL2 V 688 - G.H5 N 347 G.H5.19
Hydrophobic TM3 S 687 3x64 G.H5 I 343 G.H5.15
Van-der-waals TM3 S 687 3x64 G.H5 I 343 G.H5.15
Hydrophobic TM3 S 687 3x64 G.hns1 K 32 G.hns1.03
Van-der-waals TM4 P 696 4x29 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 680 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 680 3x57 G.H5 L 348 G.H5.20
Polar ICL1 K 619 12x51 G.H5 Y 354 G.H5.26
Hydrophobic ICL1 K 619 12x51 G.H5 Y 354 G.H5.26
Van-der-waals ICL1 K 619 12x51 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 I 694 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 694 - G.H5 C 351 G.H5.23
Van-der-waals ICL3 F 781 - G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 680 3x57 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 680 3x57 G.H5 I 344 G.H5.16
Hydrophobic ICL2 V 688 - G.S1 V 34 G.S1.02
Hydrophobic ICL3 F 781 - G.H5 L 348 G.H5.20