NK2 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

B

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XWO

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

May 31, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

48 interactions (Click to see)

LIGANDS

HIS-LYS-THR-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2 - Agonist

PHYSIOLOGICAL LIGANDS

neurokinin A, substance P, hemokinin 1, neuropeptide K, neuropeptide γ, neurokinin B



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL3 R 227 - G.H5 D 348 G.H5.13
Polar ICL3 R 227 - G.H5 D 348 G.H5.13
Hydrophobic ICL2 F 139 - G.H5 K 347 G.H5.12
Van-der-waals ICL2 F 139 - G.H5 K 347 G.H5.12
Hydrophobic TM3 R 131 3x50 G.H5 L 360 G.H5.25
Polar TM3 D 130 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 D 130 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 130 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM5 L 224 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM6 A 244 6x29 G.H5 V 361 G.H5.26
Van-der-waals TM6 A 244 6x29 G.H5 V 361 G.H5.26
Polar C-term L 310 - G.H5 N 359 G.H5.24
Hydrophobic C-term L 310 - G.H5 N 359 G.H5.24
Van-der-waals C-term L 310 - G.H5 N 359 G.H5.24
Hydrophobic ICL2 P 138 - G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 138 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 F 139 - G.H5 C 346 G.H5.11
Van-der-waals ICL2 F 139 - G.H5 C 346 G.H5.11
Hydrophobic TM6 F 248 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 355 G.H5.20
Hydrophobic C-term N 311 - G.H5 N 359 G.H5.24
Van-der-waals C-term N 311 - G.H5 N 359 G.H5.24
Hydrophobic ICL2 F 139 - G.H5 I 350 G.H5.15
Hydrophobic ICL2 F 139 - G.S3 V 194 G.S3.01
Van-der-waals ICL2 F 139 - G.S3 V 194 G.S3.01
Hydrophobic TM2 T 68 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 68 2x39 G.H5 Y 358 G.H5.23
Van-der-waals ICL3 R 227 - G.H5 Q 352 G.H5.17
Hydrophobic ICL2 P 138 - G.H5 K 347 G.H5.12
Hydrophobic TM3 I 135 3x54 G.H5 N 354 G.H5.19
Hydrophobic TM5 T 223 5x64 G.H5 L 351 G.H5.16
Aromatic ICL2 F 139 - G.H5 F 343 G.H5.08
Hydrophobic ICL2 F 139 - G.H5 F 343 G.H5.08
Van-der-waals ICL2 F 139 - G.H5 F 343 G.H5.08
Hydrophobic ICL2 F 139 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 F 139 - G.S1 L 34 G.S1.02
Polar TM3 A 134 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL3 R 227 - G.H5 L 351 G.H5.16
Polar ICL2 L 143 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 131 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 I 135 3x54 G.H5 L 351 G.H5.16
Hydrophobic TM3 A 134 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 A 134 3x53 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 141 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 141 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 252 6x37 G.H5 L 360 G.H5.25