CB1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

Jan. 30, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

MDMB-Fubinaca - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

anandamide, 2-arachidonoylglycerol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL1 S 152 - G.H5 C 351 G.H5.23
Hydrophobic TM5 H 304 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 M 308 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 221 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 221 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 337 6x29 G.H5 L 348 G.H5.20
Hydrophobic ICL3 T 313 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 T 313 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 218 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 218 3x54 G.H5 L 348 G.H5.20
Polar TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 217 3x53 G.H5 N 347 G.H5.19
Polar ICL1 R 150 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 222 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 222 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 L 341 6x33 G.H5 L 353 G.H5.25
Hydrophobic H8 S 401 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 401 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 S 217 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 T 313 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 T 313 - G.H5 F 334 G.H5.06
Hydrophobic TM6 L 341 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 214 3x50 G.H5 C 351 G.H5.23
Ionic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Polar TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic ICL2 Y 224 34x53 G.H5 N 347 G.H5.19
Polar ICL2 P 221 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 221 34x50 G.H5 N 347 G.H5.19
Polar ICL1 S 152 - G.H5 D 350 G.H5.22
Hydrophobic TM3 R 214 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 337 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 337 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 341 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 S 217 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 S 217 3x53 G.H5 L 348 G.H5.20