GABAB2 - Gi1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

May 5, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

BHFF - PAM pubchem ,

(-)-baclofen - Agonist pubchem gtoplig chembl_ligand drugbank drugbank gtoplig pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL1 M 514 12x52 G.H5 L 348 G.H5.20
Hydrophobic ICL2 M 587 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 M 587 - G.HN E 28 G.HN.52
Van-der-waals ICL2 M 587 - G.HN E 28 G.HN.52
Polar ICL2 K 588 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 588 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 588 - G.H5 N 347 G.H5.19
Polar ICL2 K 588 - G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 K 588 - G.h2s4 T 219 G.h2s4.05
Ionic ICL2 K 586 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 586 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 586 - G.s2s3 D 193 G.s2s3.02
Polar TM3 R 577 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL1 K 510 12x48 G.H5 F 354 G.H5.26
Van-der-waals ICL1 K 510 12x48 G.H5 F 354 G.H5.26
Polar ICL1 K 513 12x51 G.H5 G 352 G.H5.24
Hydrophobic ICL1 K 513 12x51 G.H5 G 352 G.H5.24
Van-der-waals ICL1 K 513 12x51 G.H5 G 352 G.H5.24
Polar ICL1 M 514 12x52 G.H5 L 353 G.H5.25
Hydrophobic ICL1 M 514 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 M 514 12x52 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 577 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 577 3x53 G.H5 L 353 G.H5.25
Polar ICL2 K 586 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 586 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 586 - G.hns1 R 32 G.hns1.03
Ionic ICL2 K 590 - G.HN E 28 G.HN.52
Hydrophobic ICL1 K 513 12x51 G.H5 F 354 G.H5.26
Van-der-waals ICL1 K 513 12x51 G.H5 F 354 G.H5.26
Hydrophobic ICL2 I 591 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 I 591 - G.H5 N 347 G.H5.19
Polar ICL2 K 593 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 593 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 K 593 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 591 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 591 - G.H5 C 351 G.H5.23
Hydrophobic TM2 S 516 2x35 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 588 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 K 588 - G.H5 I 343 G.H5.15
Polar ICL1 K 513 12x51 G.H5 L 353 G.H5.25
Hydrophobic ICL1 K 513 12x51 G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 513 12x51 G.H5 L 353 G.H5.25