GPR88 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EJX

RESOLUTION

2.4 Å

REFERENCE

10.1038/S41467-022-30081-5

PUBLICATION DATE

April 13, 2022

3D VIEW

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LIGAND INTERACTIONS

30 interactions (Click to see)

LIGANDS

compound 2 [PMID: 24793972] - Allosteric agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 138 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 142 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 138 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 351 G.H5.23
Polar ICL2 Q 150 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 L 141 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 141 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 219 5x65 G.H5 L 348 G.H5.20
Polar TM4 Q 154 4x38 G.HN R 24 G.HN.48
Hydrophobic TM3 I 142 3x54 G.H5 L 353 G.H5.25
Polar TM3 L 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 141 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 218 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 218 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 285 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 226 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 226 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM6 V 286 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 286 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 142 3x54 G.H5 N 347 G.H5.19
Polar TM4 Q 154 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 Q 154 4x38 G.HN E 28 G.HN.52
Polar TM5 R 225 5x71 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 225 5x71 G.H5 T 340 G.H5.12
Hydrophobic ICL4 R 339 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 142 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 226 5x72 G.H5 A 338 G.H5.10
Polar H8 N 340 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 340 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 340 8x47 G.H5 G 352 G.H5.24
Ionic TM5 R 225 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 225 5x71 G.H5 D 337 G.H5.09
Hydrophobic ICL2 A 147 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 I 215 5x61 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 146 34x50 G.hns1 R 32 G.hns1.03
Polar ICL2 Q 150 34x54 G.HN E 28 G.HN.52
Hydrophobic ICL2 Q 150 34x54 G.HN E 28 G.HN.52
Van-der-waals ICL2 Q 150 34x54 G.HN E 28 G.HN.52
Hydrophobic TM5 I 215 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 219 5x65 G.H5 I 344 G.H5.16
Polar TM5 S 222 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 222 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 222 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 S 222 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL4 R 339 - G.H5 L 353 G.H5.25
Hydrophobic TM5 V 226 5x72 G.H5 D 341 G.H5.13
Polar TM6 S 285 6x36 G.H5 G 352 G.H5.24
Polar H8 N 340 8x47 G.H5 D 350 G.H5.22