FFA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8J22

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41422-023-00914-Z

PUBLICATION DATE

Jan. 24, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

34 interactions (Click to see)

LIGANDS

CHEMBL4176503 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

butyric acid, trans-2-methylcrotonic acid, propanoic acid, acetic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 H 211 - G.H5 D 341 G.H5.13
Hydrophobic TM6 L 223 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 223 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 216 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 216 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 114 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 114 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 119 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM2 V 44 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM5 Q 209 5x68 G.H5 I 344 G.H5.16
Polar TM3 G 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 110 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 110 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 107 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 107 3x50 G.H5 C 351 G.H5.23
Ionic ICL2 R 121 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 121 34x57 G.H5 D 350 G.H5.22
Ionic ICL3 H 211 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 H 211 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 H 211 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 H 211 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 V 111 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL2 K 118 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 118 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 A 220 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 220 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM7 F 275 7x55 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 216 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 216 6x30 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 117 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 F 202 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM5 F 202 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 F 202 5x61 G.H5 L 353 G.H5.25
Polar TM2 H 45 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM2 H 45 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 H 45 2x40 G.H5 D 350 G.H5.22
Hydrophobic ICL2 V 115 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 119 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 119 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM2 V 44 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 44 2x39 G.H5 C 351 G.H5.23
Polar ICL2 P 114 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 114 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 118 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM4 R 122 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 R 122 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 M 206 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 114 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL1 Q 40 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 Q 40 - G.hns1 A 31 G.hns1.02
Aromatic ICL3 H 211 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 H 211 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 H 211 - G.S6 Y 320 G.S6.02
Hydrophobic ICL1 Q 40 - G.HN G 27 G.HN.51
Van-der-waals ICL1 Q 40 - G.HN G 27 G.HN.51
Hydrophobic TM3 R 107 3x50 G.H5 L 353 G.H5.25
Polar ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 119 34x55 G.hns1 R 32 G.hns1.03
Polar ICL3 H 211 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 H 211 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 V 115 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 115 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 P 114 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 114 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 111 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 118 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 F 275 7x55 G.H5 F 354 G.H5.26
Van-der-waals TM7 F 275 7x55 G.H5 F 354 G.H5.26