Refined structure (8HMV) of Gs - GPR21

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 227 from structure (57.6%), 167 from model (42.4%)
Residue sidechains - 225 from structure (57.1%), 169 from model (42.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure Structure
G.HN 12 Q G.HN.29 Structure Structure
G.HN 13 R G.HN.30 Structure Structure
G.HN 14 N G.HN.31 Structure Structure
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure Structure
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure Structure
G.HN 20 R G.HN.37 Structure Structure
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure Structure
G.HN 23 N G.HN.40 Structure Structure
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure Structure
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure Structure
G.s1h1 50 E G.s1h1.04 Structure Structure
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 AF2 AF2
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 AF2 AF2
G.hfs2 204 T G.hfs2.05 AF2 AF2
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure Structure
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 AF2 AF2
G.s4h3 253 Y G.s4h3.04 AF2 AF2
G.s4h3 254 N G.s4h3.05 AF2 AF2
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 Structure Structure
G.s4h3 263 T G.s4h3.14 Structure Structure
G.s4h3 264 N G.s4h3.15 Structure Structure
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure Structure
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 AF2 AF2
G.HG 305 K G.HG.12 AF2 AF2
G.HG 306 S G.HG.13 AF2 AF2
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure Structure
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure Structure
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 274 from structure (81.1%), 64 from model (18.9%)
Residue sidechains - 274 from structure (81.1%), 64 from model (18.9%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 S - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 L - AF2 AF2
N-term 6 D - AF2 AF2
N-term 7 G - AF2 AF2
N-term 8 N - AF2 AF2
N-term 9 Q - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 H - AF2 AF2
N-term 13 P - AF2 AF2
N-term 14 F - AF2 AF2
N-term 15 C - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 L - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 F - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 Y - AF2 AF2
N-term 22 L - AF2 AF2
N-term 23 E - AF2 AF2
N-term 24 T - AF2 AF2
TM1 25 V 1.29x29 AF2 AF2
TM1 26 N 1.30x30 AF2 AF2
TM1 27 F 1.31x31 AF2 AF2
TM1 28 C 1.32x32 AF2 AF2
TM1 29 L 1.33x33 AF2 AF2
TM1 30 L 1.34x34 Structure Structure
TM1 31 E 1.35x35 Structure Structure
TM1 32 V 1.36x36 Structure Structure
TM1 33 L 1.37x37 Structure Structure
TM1 34 I 1.38x38 Structure Structure
TM1 35 I 1.39x39 Structure Structure
TM1 36 V 1.40x40 Structure Structure
TM1 37 F 1.41x41 Structure Structure
TM1 38 L 1.42x42 Structure Structure
TM1 39 T 1.43x43 Structure Structure
TM1 40 V 1.44x44 Structure Structure
TM1 41 L 1.45x45 Structure Structure
TM1 42 I 1.46x46 Structure Structure
TM1 43 I 1.47x47 Structure Structure
TM1 44 S 1.48x48 Structure Structure
TM1 45 G 1.49x49 Structure Structure
TM1 46 N 1.50x50 Structure Structure
TM1 47 I 1.51x51 Structure Structure
TM1 48 I 1.52x52 Structure Structure
TM1 49 V 1.53x53 Structure Structure
TM1 50 I 1.54x54 Structure Structure
TM1 51 F 1.55x55 Structure Structure
TM1 52 V 1.56x56 Structure Structure
TM1 53 F 1.57x57 Structure Structure
TM1 54 H 1.58x58 Structure Structure
TM1 55 C 1.59x59 Structure Structure
TM1 56 A 1.60x60 Structure Structure
ICL1 57 P 12.48x48 Structure Structure
ICL1 58 L 12.49x49 Structure Structure
ICL1 59 L 12.50x50 Structure Structure
ICL1 60 N 12.51x51 Structure Structure
ICL1 61 H - Structure Structure
TM2 62 H 2.37x37 Structure Structure
TM2 63 T 2.38x38 Structure Structure
TM2 64 T 2.39x39 Structure Structure
TM2 65 S 2.40x40 Structure Structure
TM2 66 Y 2.41x41 Structure Structure
TM2 67 F 2.42x42 Structure Structure
TM2 68 I 2.43x43 Structure Structure
TM2 69 Q 2.44x44 Structure Structure
TM2 70 T 2.45x45 Structure Structure
TM2 71 M 2.46x46 Structure Structure
TM2 72 A 2.47x47 Structure Structure
TM2 73 Y 2.48x48 Structure Structure
TM2 74 A 2.49x49 Structure Structure
TM2 75 D 2.50x50 Structure Structure
TM2 76 L 2.51x51 Structure Structure
TM2 77 F 2.52x52 Structure Structure
TM2 78 V 2.53x53 Structure Structure
TM2 79 G 2.54x54 Structure Structure
TM2 80 V 2.55x55 Structure Structure
TM2 81 S 2.56x56 Structure Structure
TM2 82 C 2.57x57 Structure Structure
TM2 83 V 2.58x58 Structure Structure
TM2 84 V 2.59x59 Structure Structure
TM2 85 P 2.60x60 Structure Structure
TM2 86 S 2.61x61 Structure Structure
TM2 87 L 2.62x62 Structure Structure
TM2 88 S 2.63x63 Structure Structure
TM2 89 L 2.64x64 Structure Structure
TM2 90 L 2.65x65 Structure Structure
TM2 91 H 2.66x66 Structure Structure
ECL1 92 H - Structure Structure
ECL1 93 P - Structure Structure
ECL1 94 L - Structure Structure
ECL1 95 P - Structure Structure
ECL1 96 V - Structure Structure
TM3 97 E 3.20x20 Structure Structure
TM3 98 E 3.21x21 Structure Structure
TM3 99 S 3.22x22 Structure Structure
TM3 100 L 3.23x23 Structure Structure
TM3 101 T 3.24x24 Structure Structure
TM3 102 C 3.25x25 Structure Structure
TM3 103 Q 3.26x26 Structure Structure
TM3 104 I 3.27x27 Structure Structure
TM3 105 F 3.28x28 Structure Structure
TM3 106 G 3.29x29 Structure Structure
TM3 107 F 3.30x30 Structure Structure
TM3 108 V 3.31x31 Structure Structure
TM3 109 V 3.32x32 Structure Structure
TM3 110 S 3.33x33 Structure Structure
TM3 111 V 3.34x34 Structure Structure
TM3 112 L 3.35x35 Structure Structure
TM3 113 K 3.36x36 Structure Structure
TM3 114 S 3.37x37 Structure Structure
TM3 115 V 3.38x38 Structure Structure
TM3 116 S 3.39x39 Structure Structure
TM3 117 M 3.40x40 Structure Structure
TM3 118 A 3.41x41 Structure Structure
TM3 119 S 3.42x42 Structure Structure
TM3 120 L 3.43x43 Structure Structure
TM3 121 A 3.44x44 Structure Structure
TM3 122 C 3.45x45 Structure Structure
TM3 123 I 3.46x46 Structure Structure
TM3 124 S 3.47x47 Structure Structure
TM3 125 I 3.48x48 Structure Structure
TM3 126 D 3.49x49 Structure Structure
TM3 127 R 3.50x50 Structure Structure
TM3 128 Y 3.51x51 Structure Structure
TM3 129 I 3.52x52 Structure Structure
TM3 130 A 3.53x53 Structure Structure
TM3 131 I 3.54x54 Structure Structure
TM3 132 T 3.55x55 Structure Structure
TM3 133 K 3.56x56 Structure Structure
ICL2 134 P 34.50x50 Structure Structure
ICL2 135 L 34.51x51 Structure Structure
ICL2 136 T 34.52x52 Structure Structure
ICL2 137 Y 34.53x53 Structure Structure
ICL2 138 N 34.54x54 Structure Structure
ICL2 139 T 34.55x55 Structure Structure
ICL2 140 L 34.56x56 Structure Structure
ICL2 141 V 34.57x57 Structure Structure
TM4 142 T 4.38x38 Structure Structure
TM4 143 P 4.39x39 Structure Structure
TM4 144 W 4.40x40 Structure Structure
TM4 145 R 4.41x41 Structure Structure
TM4 146 L 4.42x42 Structure Structure
TM4 147 R 4.43x43 Structure Structure
TM4 148 L 4.44x44 Structure Structure
TM4 149 C 4.45x45 Structure Structure
TM4 150 I 4.46x46 Structure Structure
TM4 151 F 4.47x47 Structure Structure
TM4 152 L 4.48x48 Structure Structure
TM4 153 I 4.49x49 Structure Structure
TM4 154 W 4.50x50 Structure Structure
TM4 155 L 4.51x51 Structure Structure
TM4 156 Y 4.52x52 Structure Structure
TM4 157 S 4.53x53 Structure Structure
TM4 158 T 4.54x54 Structure Structure
TM4 159 L 4.55x55 Structure Structure
TM4 160 V 4.56x56 Structure Structure
TM4 161 F 4.57x57 Structure Structure
TM4 162 L 4.58x59 Structure Structure
TM4 163 P 4.59x60 Structure Structure
TM4 164 S 4.60x61 Structure Structure
TM4 165 F 4.61x62 Structure Structure
TM4 166 F 4.62x63 Structure Structure
ECL2 167 H - Structure Structure
ECL2 168 W - Structure Structure
ECL2 169 G - Structure Structure
ECL2 170 K - Structure Structure
ECL2 171 P - Structure Structure
ECL2 172 G - Structure Structure
ECL2 173 Y - Structure Structure
ECL2 174 H - Structure Structure
ECL2 175 G - Structure Structure
ECL2 176 D - Structure Structure
ECL2 177 V - Structure Structure
ECL2 178 F - Structure Structure
ECL2 179 Q - Structure Structure
ECL2 180 W - Structure Structure
ECL2 181 C 45.50x50 Structure Structure
ECL2 182 A 45.51x51 Structure Structure
ECL2 183 E 45.52x52 Structure Structure
ECL2 184 S - Structure Structure
ECL2 185 W - Structure Structure
ECL2 186 H - Structure Structure
ECL2 187 T - Structure Structure
TM5 188 D 5.36x37 Structure Structure
TM5 189 S 5.37x38 Structure Structure
TM5 190 Y 5.38x39 Structure Structure
TM5 191 F 5.39x40 Structure Structure
TM5 192 T 5.40x41 Structure Structure
TM5 193 L 5.41x42 Structure Structure
TM5 194 F 5.42x43 Structure Structure
TM5 195 I 5.43x44 Structure Structure
TM5 196 V 5.44x45 Structure Structure
TM5 197 M 5.45x46 Structure Structure
TM5 198 M 5.46x461 Structure Structure
TM5 199 L 5.47x47 Structure Structure
TM5 200 Y 5.48x48 Structure Structure
TM5 201 A 5.49x49 Structure Structure
TM5 202 P 5.50x50 Structure Structure
TM5 203 A 5.51x51 Structure Structure
TM5 204 A 5.52x52 Structure Structure
TM5 205 L 5.53x53 Structure Structure
TM5 206 I 5.54x54 Structure Structure
TM5 207 V 5.55x55 Structure Structure
TM5 208 C 5.56x56 Structure Structure
TM5 209 F 5.57x57 Structure Structure
TM5 210 T 5.58x58 Structure Structure
TM5 211 Y 5.59x59 Structure Structure
TM5 212 F 5.60x60 Structure Structure
TM5 213 N 5.61x61 Structure Structure
TM5 214 I 5.62x62 Structure Structure
TM5 215 F 5.63x63 Structure Structure
TM5 216 R 5.64x64 Structure Structure
TM5 217 I 5.65x65 Structure Structure
TM5 218 C 5.66x66 Structure Structure
TM5 219 Q 5.67x67 Structure Structure
TM5 220 Q 5.68x68 Structure Structure
TM5 221 H 5.69x69 Structure Structure
TM5 222 T 5.70x70 Structure Structure
TM5 223 K 5.71x71 Structure Structure
TM5 224 D 5.72x72 Structure Structure
TM5 225 I 5.73x73 Structure Structure
TM5 226 S 5.74x74 Structure Structure
TM5 227 E 5.75x75 Structure Structure
TM5 228 R 5.76x76 Structure Structure
TM5 229 Q 5.77x77 Structure Structure
TM5 230 A 5.78x78 Structure Structure
TM5 231 R 5.79x79 Structure Structure
TM5 232 F 5.80x80 Structure Structure
ICL3 233 S - Structure Structure
ICL3 234 S - AF2 AF2
ICL3 235 Q - AF2 AF2
ICL3 236 S - AF2 AF2
ICL3 237 G - AF2 AF2
ICL3 238 E - AF2 AF2
ICL3 239 T - AF2 AF2
TM6 240 G 6.23x23 AF2 AF2
TM6 241 E 6.24x24 AF2 AF2
TM6 242 V 6.25x25 AF2 AF2
TM6 243 Q 6.26x26 AF2 AF2
TM6 244 A 6.27x27 AF2 AF2
TM6 245 C 6.28x28 AF2 AF2
TM6 246 P 6.29x29 AF2 AF2
TM6 247 D 6.30x30 AF2 AF2
TM6 248 K 6.31x31 AF2 AF2
TM6 249 R 6.32x32 Structure Structure
TM6 250 Y 6.33x33 Structure Structure
TM6 251 A 6.34x34 Structure Structure
TM6 252 M 6.35x35 Structure Structure
TM6 253 V 6.36x36 Structure Structure
TM6 254 L 6.37x37 Structure Structure
TM6 255 F 6.38x38 Structure Structure
TM6 256 R 6.39x39 Structure Structure
TM6 257 I 6.40x40 Structure Structure
TM6 258 T 6.41x41 Structure Structure
TM6 259 S 6.42x42 Structure Structure
TM6 260 V 6.43x43 Structure Structure
TM6 261 F 6.44x44 Structure Structure
TM6 262 Y 6.45x45 Structure Structure
TM6 263 I 6.46x46 Structure Structure
TM6 264 L 6.47x47 Structure Structure
TM6 265 W 6.48x48 Structure Structure
TM6 266 L 6.49x49 Structure Structure
TM6 267 P 6.50x50 Structure Structure
TM6 268 Y 6.51x51 Structure Structure
TM6 269 I 6.52x52 Structure Structure
TM6 270 I 6.53x53 Structure Structure
TM6 271 Y 6.54x54 Structure Structure
TM6 272 F 6.55x55 Structure Structure
TM6 273 L 6.56x56 Structure Structure
TM6 274 L 6.57x57 Structure Structure
TM6 275 E 6.58x58 Structure Structure
TM6 276 S 6.59x59 Structure Structure
TM6 277 S 6.60x60 Structure Structure
TM6 278 T 6.61x61 Structure Structure
ECL3 279 G - Structure Structure
ECL3 280 H - Structure Structure
ECL3 281 S - Structure Structure
ECL3 282 N - Structure Structure
TM7 283 R 7.32x31 Structure Structure
TM7 284 F 7.33x32 Structure Structure
TM7 285 A 7.34x33 Structure Structure
TM7 286 S 7.35x34 Structure Structure
TM7 287 F 7.36x35 Structure Structure
TM7 288 L 7.37x36 Structure Structure
TM7 289 T 7.38x37 Structure Structure
TM7 290 T 7.39x38 Structure Structure
TM7 291 W 7.40x39 Structure Structure
TM7 292 L 7.41x40 Structure Structure
TM7 293 A 7.42x41 Structure Structure
TM7 294 I 7.43x42 Structure Structure
TM7 295 S 7.44x43 Structure Structure
TM7 296 N 7.45x45 Structure Structure
TM7 297 S 7.46x46 Structure Structure
TM7 298 F 7.47x47 Structure Structure
TM7 299 C 7.48x48 Structure Structure
TM7 300 N 7.49x49 Structure Structure
TM7 301 C 7.50x50 Structure Structure
TM7 302 V 7.51x51 Structure Structure
TM7 303 I 7.52x52 Structure Structure
TM7 304 Y 7.53x53 Structure Structure
TM7 305 S 7.54x54 Structure Structure
TM7 306 L 7.55x55 Structure Structure
TM7 307 S 7.56x56 Structure Structure
H8 308 N 8.47x47 Structure Structure
H8 309 S 8.48x48 Structure Structure
H8 310 V 8.49x49 Structure Structure
H8 311 F 8.50x50 Structure Structure
H8 312 Q 8.51x51 Structure Structure
H8 313 R 8.52x52 Structure Structure
H8 314 G 8.53x53 Structure Structure
H8 315 L 8.54x54 Structure Structure
H8 316 K 8.55x55 Structure Structure
H8 317 R 8.56x56 Structure Structure
H8 318 L 8.57x57 Structure Structure
H8 319 S 8.58x58 AF2 AF2
H8 320 G 8.59x59 AF2 AF2
H8 321 A 8.60x60 AF2 AF2
H8 322 M 8.61x61 AF2 AF2
H8 323 C 8.62x62 AF2 AF2
H8 324 T 8.63x63 AF2 AF2
H8 325 S 8.64x64 AF2 AF2
H8 326 C 8.65x65 AF2 AF2
H8 327 A 8.66x66 AF2 AF2
H8 328 S 8.67x67 AF2 AF2
C-term 329 Q - AF2 AF2
C-term 330 T - AF2 AF2
C-term 331 T - AF2 AF2
C-term 332 A - AF2 AF2
C-term 333 N - AF2 AF2
C-term 334 D - AF2 AF2
C-term 335 P - AF2 AF2
C-term 336 Y - AF2 AF2
C-term 337 T - AF2 AF2
C-term 338 V - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 134 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 134 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 F 232 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM6 L 254 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 254 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 135 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 217 5x65 G.H5 L 388 G.H5.20
Polar TM2 H 62 2x37 G.H5 Q 390 G.H5.22
Polar TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 134 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM6 Y 250 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 Y 250 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM4 T 142 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 I 214 5x62 G.H5 L 388 G.H5.20
Polar ICL3 Q 235 - G.H4 R 347 G.H4.17
Hydrophobic ICL3 Q 235 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 Q 235 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 P 134 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 383 G.H5.15
Polar H8 S 309 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 I 214 5x62 G.H5 L 393 G.H5.25
Van-der-waals TM5 R 231 5x79 G.hgh4 P 321 G.hgh4.11
Polar H8 N 308 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM5 R 228 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 R 228 5x76 G.H4 L 346 G.H4.16
Hydrophobic TM3 I 131 3x54 G.H5 L 393 G.H5.25
Polar TM3 T 132 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 T 132 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 Y 137 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 F 232 5x80 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 F 232 5x80 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 L 135 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 135 34x51 G.H5 I 383 G.H5.15
Aromatic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 R 228 5x76 G.h4s6 T 350 G.h4s6.03
Ionic TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Polar TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 L 135 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM5 C 218 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 C 218 5x66 G.H5 L 388 G.H5.20
Hydrophobic TM3 A 130 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 217 5x65 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 221 5x69 G.H5 L 388 G.H5.20
Hydrophobic TM5 F 232 5x80 G.H4 D 343 G.H4.13
Polar TM6 R 249 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 249 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 249 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 N 138 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 F 232 5x80 G.H4 R 347 G.H4.17
Van-der-waals TM5 F 232 5x80 G.H4 R 347 G.H4.17
Hydrophobic TM6 V 253 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 V 253 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 Q 229 5x77 G.h4s6 T 350 G.h4s6.03
Aromatic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Polar ICL2 L 135 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 135 34x51 G.S1 H 41 G.S1.02
Polar TM3 A 130 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 136 34x52 G.S3 V 217 G.S3.01
Ionic TM5 H 221 5x69 G.H5 D 381 G.H5.13
Polar TM5 H 221 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 221 5x69 G.H5 D 381 G.H5.13
Polar TM5 R 228 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 228 5x76 G.S6 C 359 G.S6.01
Hydrophobic TM6 V 253 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 253 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 225 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 225 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM3 I 131 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 135 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 135 34x51 G.H5 F 376 G.H5.08
Polar TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Aromatic TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Ionic TM6 R 249 6x32 G.H5 E 392 G.H5.24
Polar TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 135 34x51 G.H5 R 380 G.H5.12
Polar TM5 C 218 5x66 G.H5 L 393 G.H5.25
Hydrophobic TM5 C 218 5x66 G.H5 L 393 G.H5.25
Van-der-waals TM5 C 218 5x66 G.H5 L 393 G.H5.25
Polar TM5 D 224 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 I 131 3x54 G.H5 H 387 G.H5.19