GPR21 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HMV

RESOLUTION

2.9 Å

REFERENCE

10.1002/MCO2.205

PUBLICATION DATE

March 1, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 137 - G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 136 - G.S3 V 217 G.S3.01
Polar TM5 D 224 5x72 G.h4s6 Y 358 G.h4s6.20
Polar TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 221 5x69 G.H5 Q 384 G.H5.16
Polar TM6 R 249 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 249 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 249 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 F 232 5x80 G.H4 R 347 G.H4.17
Polar TM3 T 132 3x55 G.H5 R 380 G.H5.12
Van-der-waals TM3 T 132 3x55 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 134 - G.H5 Q 384 G.H5.16
Hydrophobic TM5 F 232 5x80 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 I 131 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 217 5x65 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 135 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 131 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 388 G.H5.20
Aromatic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 Y 391 G.H5.23
Polar TM5 C 218 5x66 G.H5 L 393 G.H5.25
Hydrophobic TM5 C 218 5x66 G.H5 L 393 G.H5.25
Van-der-waals TM5 C 218 5x66 G.H5 L 393 G.H5.25
Hydrophobic TM5 F 232 5x80 G.H4 L 346 G.H4.16
Van-der-waals TM5 F 232 5x80 G.H4 L 346 G.H4.16
Hydrophobic TM5 C 218 5x66 G.H5 L 388 G.H5.20
Van-der-waals TM5 C 218 5x66 G.H5 L 388 G.H5.20
Hydrophobic TM5 I 214 5x62 G.H5 L 393 G.H5.25
Hydrophobic ICL2 N 138 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 135 - G.H5 R 380 G.H5.12
Hydrophobic TM5 F 232 5x80 G.H4 D 343 G.H4.13
Hydrophobic TM6 V 253 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 253 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 Q 229 5x77 G.h4s6 T 350 G.h4s6.03
Hydrophobic TM3 I 131 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 R 228 5x76 G.H4 L 346 G.H4.16
Van-der-waals TM5 R 228 5x76 G.H4 L 346 G.H4.16
Polar H8 N 308 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 134 - G.H5 H 387 G.H5.19
Polar TM5 R 228 5x76 G.S6 C 359 G.S6.01
Van-der-waals TM5 R 228 5x76 G.S6 C 359 G.S6.01
Polar ICL1 H 62 - G.H5 Q 390 G.H5.22
Hydrophobic TM6 Y 250 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 Y 250 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 135 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 135 - G.H5 I 383 G.H5.15
Hydrophobic TM4 T 142 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM5 I 225 5x73 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 225 5x73 G.H5 R 385 G.H5.17
Hydrophobic TM5 R 228 5x76 G.h4s6 T 350 G.h4s6.03
Ionic TM6 R 249 6x32 G.H5 E 392 G.H5.24
Polar TM6 R 249 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 249 6x32 G.H5 E 392 G.H5.24
Ionic TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Polar TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 R 231 5x79 G.hgh4 D 323 G.hgh4.13
Polar TM3 A 130 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 H 387 G.H5.19
Polar H8 S 309 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 131 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM3 A 130 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 130 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 134 - G.H5 R 380 G.H5.12
Polar TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 Q 384 G.H5.16
Polar TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Aromatic TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 R 228 5x76 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 P 134 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 134 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 L 135 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 135 - G.H5 F 376 G.H5.08
Hydrophobic TM6 V 253 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 V 253 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 135 - G.H5 C 379 G.H5.11
Hydrophobic TM5 I 214 5x62 G.H5 L 388 G.H5.20
Van-der-waals TM5 R 231 5x79 G.hgh4 P 321 G.hgh4.11
Hydrophobic TM6 L 254 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 254 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 217 5x65 G.H5 L 388 G.H5.20
Polar ICL2 L 135 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 135 - G.S1 H 41 G.S1.02
Aromatic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 221 5x69 G.H5 R 385 G.H5.17
Ionic TM5 H 221 5x69 G.H5 D 381 G.H5.13
Polar TM5 H 221 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 221 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 221 5x69 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 221 5x69 G.H5 L 388 G.H5.20