Refined structure (8TZQ) of Go - D2 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-11-26

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 221 from structure (62.4%), 133 from model (37.6%)
Residue sidechains - 213 from structure (60.2%), 141 from model (39.8%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 E G.HN.33 Structure Structure
G.HN 10 R G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 L G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 A G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 E G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 K G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 I G.HN.52 Structure Structure
G.HN 29 S G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 K G.hns1.03 Structure Structure
G.S1 33 D G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure Structure
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 F G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 G H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 D H.HA.03 AF2 AF2
H.HA 66 V H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 P H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 L H.HA.19 AF2 AF2
H.HA 82 A H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 D H.HA.27 AF2 AF2
H.HA 90 T H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 G H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 E H.hahb.05 AF2 AF2
H.hahb 95 Y H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 K H.hahb.09 AF2 AF2
H.HB 99 E H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 K H.HB.03 AF2 AF2
H.HB 102 A H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 K H.HB.07 AF2 AF2
H.HB 106 M H.HB.08 AF2 AF2
H.HB 107 V H.HB.09 AF2 AF2
H.HB 108 C H.HB.10 AF2 AF2
H.HB 109 D H.HB.11 AF2 AF2
H.HB 110 V H.HB.12 AF2 AF2
H.HB 111 V H.HB.13 AF2 AF2
H.HB 112 S H.HB.14 AF2 AF2
H.hbhc 113 R H.hbhc.01 AF2 AF2
H.hbhc 114 M H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 D H.hbhc.04 AF2 AF2
H.hbhc 117 T H.hbhc.05 AF2 AF2
H.hbhc 118 E H.hbhc.12 AF2 AF2
H.hbhc 119 P H.hbhc.13 AF2 AF2
H.hbhc 120 F H.hbhc.14 AF2 AF2
H.hbhc 121 S H.hbhc.15 AF2 AF2
H.HC 122 A H.HC.01 AF2 AF2
H.HC 123 E H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 L H.HC.04 AF2 AF2
H.HC 126 S H.HC.05 AF2 AF2
H.HC 127 A H.HC.06 AF2 AF2
H.HC 128 M H.HC.07 AF2 AF2
H.HC 129 M H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 G H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 S H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 I H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 E H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 N H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 K H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 D H.HE.07 AF2 AF2
H.HE 159 S H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 D H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 G H.HE.13 AF2 AF2
H.hehf 165 A H.hehf.01 AF2 AF2
H.hehf 166 A H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 Q H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 E H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 I H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 AF2 AF2
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 N G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 R G.S3.04 Structure Structure
G.S3 199 L G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure Structure
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 D G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure Structure
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 G G.s4h3.03 Structure Structure
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 Structure Structure
G.s4h3 233 Q G.s4h3.06 Structure Structure
G.s4h3 234 V G.s4h3.07 Structure Structure
G.s4h3 235 L G.s4h3.08 Structure Structure
G.s4h3 236 H G.s4h3.09 Structure AF2
G.s4h3 237 E G.s4h3.10 Structure AF2
G.s4h3 238 D G.s4h3.11 Structure Structure
G.s4h3 239 E G.s4h3.12 Structure AF2
G.s4h3 240 T G.s4h3.13 Structure Structure
G.s4h3 241 T G.s4h3.14 Structure Structure
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure Structure
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 L G.H3.06 Structure Structure
G.H3 249 M G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure AF2
G.H3 259 F G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 I G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 G G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 K G.HG.09 Structure Structure
G.HG 281 K G.HG.12 Structure AF2
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure Structure
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 P G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 T G.H4.02 Structure Structure
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 E G.H4.04 Structure Structure
G.H4 299 D G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 A G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 A G.H4.13 Structure Structure
G.H4 307 Q G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 S G.H4.17 Structure Structure
G.h4s6 311 K G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 R G.h4s6.03 Structure Structure
G.h4s6 314 S G.h4s6.08 Structure Structure
G.h4s6 315 P G.h4s6.09 Structure Structure
G.h4s6 316 N G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 C G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 M G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure Structure
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 N G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 I G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 V G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 I G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 A G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 R G.H5.21 Structure Structure
G.H5 350 G G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 Y G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 269 from structure (83.5%), 53 from model (16.5%)
Residue sidechains - 260 from structure (80.7%), 62 from model (19.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 L - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 W - AF2 AF2
N-term 9 Y - AF2 AF2
N-term 10 D - AF2 AF2
N-term 11 D - AF2 AF2
N-term 12 D - AF2 AF2
N-term 13 L - AF2 AF2
N-term 14 E - AF2 AF2
N-term 15 R - AF2 AF2
N-term 16 Q - AF2 AF2
N-term 17 N - AF2 AF2
N-term 18 W - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 R - AF2 AF2
N-term 21 P - AF2 AF2
N-term 22 F - AF2 AF2
N-term 23 N - AF2 AF2
N-term 24 G - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 D - AF2 AF2
N-term 27 G - AF2 AF2
N-term 28 K - AF2 AF2
N-term 29 A - AF2 AF2
N-term 30 D - AF2 AF2
TM1 31 R 1.29x29 AF2 AF2
TM1 32 P 1.30x30 AF2 AF2
TM1 33 H 1.31x31 AF2 AF2
TM1 34 Y 1.32x32 AF2 AF2
TM1 35 N 1.33x33 AF2 AF2
TM1 36 Y 1.34x34 AF2 AF2
TM1 37 Y 1.35x35 Structure Structure
TM1 38 A 1.36x36 Structure Structure
TM1 39 T 1.37x37 Structure Structure
TM1 40 L 1.38x38 Structure Structure
TM1 41 L 1.39x39 Structure Structure
TM1 42 T 1.40x40 Structure Structure
TM1 43 L 1.41x41 Structure Structure
TM1 44 L 1.42x42 Structure Structure
TM1 45 I 1.43x43 Structure Structure
TM1 46 A 1.44x44 Structure Structure
TM1 47 V 1.45x45 Structure Structure
TM1 48 I 1.46x46 Structure Structure
TM1 49 V 1.47x47 Structure Structure
TM1 50 F 1.48x48 Structure Structure
TM1 51 G 1.49x49 Structure Structure
TM1 52 N 1.50x50 Structure Structure
TM1 53 V 1.51x51 Structure Structure
TM1 54 L 1.52x52 Structure Structure
TM1 55 V 1.53x53 Structure Structure
TM1 56 C 1.54x54 Structure Structure
TM1 57 M 1.55x55 Structure Structure
TM1 58 A 1.56x56 Structure Structure
TM1 59 V 1.57x57 Structure Structure
TM1 60 S 1.58x58 Structure Structure
TM1 61 R 1.59x59 Structure Structure
TM1 62 E 1.60x60 Structure Structure
ICL1 63 K 12.48x48 Structure AF2
ICL1 64 A 12.49x49 Structure Structure
ICL1 65 L 12.50x50 Structure Structure
ICL1 66 Q 12.51x51 Structure Structure
TM2 67 T 2.37x37 Structure Structure
TM2 68 T 2.38x38 Structure Structure
TM2 69 T 2.39x39 Structure Structure
TM2 70 N 2.40x40 Structure Structure
TM2 71 Y 2.41x41 Structure Structure
TM2 72 L 2.42x42 Structure Structure
TM2 73 I 2.43x43 Structure Structure
TM2 74 V 2.44x44 Structure Structure
TM2 75 S 2.45x45 Structure Structure
TM2 76 L 2.46x46 Structure Structure
TM2 77 A 2.47x47 Structure Structure
TM2 78 V 2.48x48 Structure Structure
TM2 79 A 2.49x49 Structure Structure
TM2 80 D 2.50x50 Structure Structure
TM2 81 L 2.51x51 Structure Structure
TM2 82 L 2.52x52 Structure Structure
TM2 83 V 2.53x53 Structure Structure
TM2 84 A 2.54x54 Structure Structure
TM2 85 T 2.55x55 Structure Structure
TM2 86 L 2.56x551 Structure Structure
TM2 87 V 2.57x56 Structure Structure
TM2 88 M 2.58x57 Structure Structure
TM2 89 P 2.59x58 Structure Structure
TM2 90 W 2.60x59 Structure Structure
TM2 91 V 2.61x60 Structure Structure
TM2 92 V 2.62x61 Structure Structure
TM2 93 Y 2.63x62 Structure Structure
TM2 94 L 2.64x63 Structure Structure
TM2 95 E 2.65x64 Structure Structure
TM2 96 V 2.66x65 Structure Structure
TM2 97 V 2.67x66 Structure Structure
TM2 98 G 2.68x67 Structure Structure
ECL1 99 E 23.49x49 Structure AF2
ECL1 100 W 23.50x50 Structure Structure
ECL1 101 K 23.51x51 Structure AF2
ECL1 102 F 23.52x52 Structure Structure
TM3 103 S 3.21x21 Structure Structure
TM3 104 R 3.22x22 Structure Structure
TM3 105 I 3.23x23 Structure Structure
TM3 106 H 3.24x24 Structure Structure
TM3 107 C 3.25x25 Structure Structure
TM3 108 D 3.26x26 Structure Structure
TM3 109 I 3.27x27 Structure Structure
TM3 110 F 3.28x28 Structure Structure
TM3 111 V 3.29x29 Structure Structure
TM3 112 T 3.30x30 Structure Structure
TM3 113 L 3.31x31 Structure Structure
TM3 114 D 3.32x32 Structure Structure
TM3 115 V 3.33x33 Structure Structure
TM3 116 M 3.34x34 Structure Structure
TM3 117 M 3.35x35 Structure Structure
TM3 118 C 3.36x36 Structure Structure
TM3 119 T 3.37x37 Structure Structure
TM3 120 A 3.38x38 Structure Structure
TM3 121 S 3.39x39 Structure Structure
TM3 122 I 3.40x40 Structure Structure
TM3 123 L 3.41x41 Structure Structure
TM3 124 N 3.42x42 Structure Structure
TM3 125 L 3.43x43 Structure Structure
TM3 126 C 3.44x44 Structure Structure
TM3 127 A 3.45x45 Structure Structure
TM3 128 I 3.46x46 Structure Structure
TM3 129 S 3.47x47 Structure Structure
TM3 130 I 3.48x48 Structure Structure
TM3 131 D 3.49x49 Structure Structure
TM3 132 R 3.50x50 Structure Structure
TM3 133 Y 3.51x51 Structure Structure
TM3 134 T 3.52x52 Structure Structure
TM3 135 A 3.53x53 Structure Structure
TM3 136 V 3.54x54 Structure Structure
TM3 137 A 3.55x55 Structure Structure
TM3 138 M 3.56x56 Structure Structure
ICL2 139 P 34.50x50 Structure Structure
ICL2 140 M 34.51x51 Structure Structure
ICL2 141 L 34.52x52 Structure Structure
ICL2 142 Y 34.53x53 Structure Structure
ICL2 143 N 34.54x54 Structure Structure
TM4 144 T 4.34x34 Structure Structure
TM4 145 R 4.35x35 Structure AF2
TM4 146 Y 4.36x36 Structure Structure
TM4 147 S 4.37x37 Structure Structure
TM4 148 S 4.38x38 Structure Structure
TM4 149 K 4.39x39 Structure AF2
TM4 150 R 4.40x40 Structure AF2
TM4 151 R 4.41x41 Structure Structure
TM4 152 V 4.42x42 Structure Structure
TM4 153 T 4.43x43 Structure Structure
TM4 154 V 4.44x44 Structure Structure
TM4 155 M 4.45x45 Structure Structure
TM4 156 I 4.46x46 Structure Structure
TM4 157 S 4.47x47 Structure Structure
TM4 158 I 4.48x48 Structure Structure
TM4 159 V 4.49x49 Structure Structure
TM4 160 W 4.50x50 Structure Structure
TM4 161 V 4.51x51 Structure Structure
TM4 162 L 4.52x52 Structure Structure
TM4 163 S 4.53x53 Structure Structure
TM4 164 F 4.54x54 Structure Structure
TM4 165 T 4.55x55 Structure Structure
TM4 166 I 4.56x56 Structure Structure
TM4 167 S 4.57x57 Structure Structure
TM4 168 C 4.58x59 Structure Structure
TM4 169 P 4.59x60 Structure Structure
TM4 170 L 4.60x61 Structure Structure
TM4 171 L 4.61x62 Structure Structure
TM4 172 F 4.62x63 Structure Structure
TM4 173 G 4.63x64 Structure Structure
ECL2 174 L - Structure Structure
ECL2 175 N - Structure Structure
ECL2 176 N - Structure Structure
ECL2 177 A - Structure Structure
ECL2 178 D - Structure Structure
ECL2 179 Q - Structure AF2
ECL2 180 N - Structure Structure
ECL2 181 E - Structure Structure
ECL2 182 C 45.50x50 Structure Structure
ECL2 183 I 45.51x51 Structure Structure
ECL2 184 I 45.52x52 Structure Structure
ECL2 185 A - Structure Structure
TM5 186 N 5.35x36 Structure Structure
TM5 187 P 5.36x37 Structure Structure
TM5 188 A 5.37x38 Structure Structure
TM5 189 F 5.38x39 Structure Structure
TM5 190 V 5.39x40 Structure Structure
TM5 191 V 5.40x41 Structure Structure
TM5 192 Y 5.41x42 Structure Structure
TM5 193 S 5.42x43 Structure Structure
TM5 194 S 5.43x44 Structure Structure
TM5 195 I 5.44x45 Structure Structure
TM5 196 V 5.45x46 Structure Structure
TM5 197 S 5.46x461 Structure Structure
TM5 198 F 5.47x47 Structure Structure
TM5 199 Y 5.48x48 Structure Structure
TM5 200 V 5.49x49 Structure Structure
TM5 201 P 5.50x50 Structure Structure
TM5 202 F 5.51x51 Structure Structure
TM5 203 I 5.52x52 Structure Structure
TM5 204 V 5.53x53 Structure Structure
TM5 205 T 5.54x54 Structure Structure
TM5 206 L 5.55x55 Structure Structure
TM5 207 L 5.56x56 Structure Structure
TM5 208 V 5.57x57 Structure Structure
TM5 209 Y 5.58x58 Structure Structure
TM5 210 I 5.59x59 Structure Structure
TM5 211 K 5.60x60 Structure Structure
TM5 212 I 5.61x61 Structure Structure
TM5 213 Y 5.62x62 Structure Structure
TM5 214 I 5.63x63 Structure Structure
TM5 215 V 5.64x64 Structure Structure
TM5 216 L 5.65x65 Structure Structure
TM5 217 R 5.66x66 Structure AF2
TM5 218 R 5.67x67 Structure Structure
TM5 219 R 5.68x68 Structure Structure
TM5 220 R 5.69x69 Structure Structure
TM5 221 K 5.70x70 Structure Structure
TM5 222 R 5.71x71 Structure Structure
TM5 223 V 5.72x72 Structure Structure
TM5 224 N 5.73x73 Structure Structure
TM5 225 T 5.74x74 AF2 AF2
TM5 226 K 5.75x75 AF2 AF2
ICL3 227 R - AF2 AF2
ICL3 228 S - AF2 AF2
ICL3 229 S - AF2 AF2
ICL3 230 R - AF2 AF2
ICL3 231 A - AF2 AF2
ICL3 232 F - AF2 AF2
ICL3 233 R - AF2 AF2
ICL3 355 L - AF2 AF2
ICL3 356 K - AF2 AF2
ICL3 357 T - AF2 AF2
ICL3 358 M - AF2 AF2
ICL3 359 S - AF2 AF2
ICL3 360 R - AF2 AF2
ICL3 361 R - Structure Structure
TM6 362 K 6.24x24 Structure Structure
TM6 363 L 6.25x25 Structure Structure
TM6 364 S 6.26x26 Structure Structure
TM6 365 Q 6.27x27 Structure Structure
TM6 366 Q 6.28x28 Structure Structure
TM6 367 K 6.29x29 Structure Structure
TM6 368 E 6.30x30 Structure Structure
TM6 369 K 6.31x31 Structure Structure
TM6 370 K 6.32x32 Structure Structure
TM6 371 A 6.33x33 Structure Structure
TM6 372 T 6.34x34 Structure Structure
TM6 373 Q 6.35x35 Structure Structure
TM6 374 M 6.36x36 Structure Structure
TM6 375 L 6.37x37 Structure Structure
TM6 376 A 6.38x38 Structure Structure
TM6 377 I 6.39x39 Structure Structure
TM6 378 V 6.40x40 Structure Structure
TM6 379 L 6.41x41 Structure Structure
TM6 380 G 6.42x42 Structure Structure
TM6 381 V 6.43x43 Structure Structure
TM6 382 F 6.44x44 Structure Structure
TM6 383 I 6.45x45 Structure Structure
TM6 384 I 6.46x46 Structure Structure
TM6 385 C 6.47x47 Structure Structure
TM6 386 W 6.48x48 Structure Structure
TM6 387 L 6.49x49 Structure Structure
TM6 388 P 6.50x50 Structure Structure
TM6 389 F 6.51x51 Structure Structure
TM6 390 F 6.52x52 Structure Structure
TM6 391 I 6.53x53 Structure Structure
TM6 392 T 6.54x54 Structure Structure
TM6 393 H 6.55x55 Structure Structure
TM6 394 I 6.56x56 Structure Structure
TM6 395 L 6.57x57 Structure Structure
TM6 396 N 6.58x58 Structure Structure
TM6 397 I 6.59x59 Structure Structure
TM6 398 H 6.60x60 Structure Structure
TM6 399 C 6.61x61 Structure Structure
ECL3 400 D - Structure Structure
ECL3 401 C - Structure Structure
ECL3 402 N - Structure Structure
ECL3 403 I - Structure Structure
TM7 404 P 7.31x30 Structure Structure
TM7 405 P 7.32x31 Structure Structure
TM7 406 V 7.33x32 Structure Structure
TM7 407 L 7.34x33 Structure Structure
TM7 408 Y 7.35x34 Structure Structure
TM7 409 S 7.36x35 Structure Structure
TM7 410 A 7.37x36 Structure Structure
TM7 411 F 7.38x37 Structure Structure
TM7 412 T 7.39x38 Structure Structure
TM7 413 W 7.40x39 Structure Structure
TM7 414 L 7.41x40 Structure Structure
TM7 415 G 7.42x41 Structure Structure
TM7 416 Y 7.43x42 Structure Structure
TM7 417 V 7.44x43 Structure Structure
TM7 418 N 7.45x45 Structure Structure
TM7 419 S 7.46x46 Structure Structure
TM7 420 A 7.47x47 Structure Structure
TM7 421 V 7.48x48 Structure Structure
TM7 422 N 7.49x49 Structure Structure
TM7 423 P 7.50x50 Structure Structure
TM7 424 I 7.51x51 Structure Structure
TM7 425 I 7.52x52 Structure Structure
TM7 426 Y 7.53x53 Structure Structure
TM7 427 T 7.54x54 Structure Structure
TM7 428 T 7.55x55 Structure Structure
TM7 429 F 7.56x56 Structure Structure
H8 430 N 8.47x47 Structure Structure
H8 431 I 8.48x48 Structure Structure
H8 432 E 8.49x49 Structure Structure
H8 433 F 8.50x50 Structure Structure
H8 434 R 8.51x51 Structure Structure
H8 435 K 8.52x52 Structure Structure
H8 436 A 8.53x53 Structure Structure
H8 437 F 8.54x54 Structure Structure
H8 438 L 8.55x55 Structure Structure
H8 439 K 8.56x56 Structure AF2
H8 440 I 8.57x57 Structure Structure
H8 441 L 8.58x58 Structure Structure
H8 442 H 8.59x59 AF2 AF2
C-term 443 C - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 360 - G.h4s6 N 312 G.h4s6.02
Hydrophobic ICL3 R 360 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 R 360 - G.h4s6 N 312 G.h4s6.02
Hydrophobic ICL2 Y 142 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 142 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 N 143 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 N 143 34x54 G.H5 N 347 G.H5.19
Hydrophobic TM4 Y 146 4x36 G.HN K 24 G.HN.48
Hydrophobic TM3 V 136 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 136 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 367 6x29 G.H5 R 349 G.H5.21
Van-der-waals TM6 K 367 6x29 G.H5 R 349 G.H5.21
Polar TM3 A 135 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 135 3x53 G.H5 N 347 G.H5.19
Polar ICL3 R 230 - G.S6 C 321 G.S6.03
Hydrophobic ICL3 R 230 - G.S6 C 321 G.S6.03
Van-der-waals ICL3 R 230 - G.S6 C 321 G.S6.03
Polar TM2 T 69 2x39 G.H5 G 350 G.H5.22
Van-der-waals TM2 T 69 2x39 G.H5 G 350 G.H5.22
Hydrophobic ICL2 P 139 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 139 34x50 G.H5 I 343 G.H5.15
Ionic TM5 R 219 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 219 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 219 5x68 G.H5 D 341 G.H5.13
Polar TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 375 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 375 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 T 357 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 T 357 - G.H4 E 309 G.H4.16
Hydrophobic ICL2 P 139 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 139 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 355 - G.H4 Y 303 G.H4.10
Hydrophobic ICL2 M 140 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 140 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM4 Y 146 4x36 G.HN I 28 G.HN.52
Van-der-waals TM4 Y 146 4x36 G.HN I 28 G.HN.52
Hydrophobic ICL3 R 233 - G.hgh4 P 294 G.hgh4.08
Hydrophobic TM3 A 135 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 135 3x53 G.H5 C 351 G.H5.23
Ionic TM5 K 226 5x75 G.H5 D 337 G.H5.09
Polar TM5 K 226 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 226 5x75 G.H5 D 337 G.H5.09
Polar ICL3 R 360 - G.H4 E 309 G.H4.16
Polar ICL3 R 230 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 R 230 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 R 230 - G.S6 H 322 G.S6.04
Ionic ICL3 R 233 - G.H4 D 299 G.H4.05
Polar ICL3 R 233 - G.H4 D 299 G.H4.05
Hydrophobic ICL3 R 233 - G.H4 D 299 G.H4.05
Van-der-waals ICL3 R 233 - G.H4 D 299 G.H4.05
Hydrophobic TM6 A 371 6x33 G.H5 L 353 G.H5.25
Polar ICL2 Y 142 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 142 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 N 143 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 L 216 5x65 G.H5 Y 354 G.H5.26
Van-der-waals TM5 L 216 5x65 G.H5 Y 354 G.H5.26
Hydrophobic TM6 A 371 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 A 371 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM3 R 132 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 132 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 370 6x32 G.H5 Y 354 G.H5.26
Polar ICL2 P 139 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 139 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 M 374 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 219 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 355 - G.H4 A 302 G.H4.08
Hydrophobic TM6 K 367 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 367 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 E 368 6x30 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 M 140 34x51 G.S1 V 34 G.S1.02
Hydrophobic ICL2 M 140 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 140 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM2 T 69 2x39 G.H5 C 351 G.H5.23