S1P5 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7EW1

RESOLUTION

3.4 Å

REFERENCE

10.1038/S41422-021-00566-X

PUBLICATION DATE

Sept. 29, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

45 interactions (Click to see)

LIGANDS

siponimod - Agonist pubchem gtoplig chembl_ligand drug_central drugbank

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate, sphingosylphosphorylcholine, dihydrosphingosine 1-phosphate



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 M 71 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 71 2x39 G.H5 C 351 G.H5.23
Ionic TM3 R 139 3x56 G.H5 D 350 G.H5.22
Polar TM3 R 139 3x56 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 139 3x56 G.H5 D 350 G.H5.22
Ionic ICL3 R 245 - G.H5 D 341 G.H5.13
Polar ICL3 R 245 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 245 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 142 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 142 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 226 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 L 226 - G.H5 T 340 G.H5.12
Polar TM3 T 136 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 T 136 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 M 137 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 M 137 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 M 137 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 N 222 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 N 222 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 226 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 142 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 P 142 - G.S1 E 33 G.S1.01
Ionic ICL3 R 245 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 245 - G.h4s6 E 318 G.h4s6.12
Polar TM3 R 139 3x56 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 139 3x56 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 133 3x50 G.H5 L 353 G.H5.25
Polar TM6 T 252 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 252 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 252 6x36 G.H5 L 353 G.H5.25
Van-der-waals ICL2 P 142 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 142 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 P 142 - G.S1 V 34 G.S1.02
Ionic ICL2 R 140 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 140 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 T 136 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 T 136 3x53 G.H5 C 351 G.H5.23
Polar TM3 M 137 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 M 137 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM5 A 223 5x69 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 249 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 249 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 140 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 R 140 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 R 140 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 245 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 245 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 142 - G.H5 I 343 G.H5.15
Hydrophobic TM6 L 253 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 226 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 226 - G.H5 D 337 G.H5.09
Hydrophobic TM6 L 249 6x33 G.H5 L 348 G.H5.20
Polar TM3 R 133 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 C 351 G.H5.23