S1P5 receptor (s1pr5_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P5 receptor
GENE
S1PR5 (EDG8)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Sphingosine 1-phosphate receptor 5, S1P receptor 5, S1P5, Endothelial differentiation G-protein-coupled receptor 8, Sphingosine 1-phosphate receptor Edg-8, S1P receptor Edg-8
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
S
|
G
|
L
|
L
|
R
|
P
|
A
|
P
|
10 |
V
|
S
|
E
|
V
|
I
|
V
|
L
|
H
|
Y
|
N
|
20 |
Y
|
T
|
G
|
K
|
L
|
R
|
G
|
A
|
R
|
Y
|
30 |
TM1 | |||||||||
Q
|
P
|
G
|
A
|
G
|
L
|
R
|
A
|
D
|
A
|
40 |
V
|
V
|
C
|
L
|
A
|
V
|
C
|
A
|
F
|
I
|
50 |
V
|
L
|
E
|
N
|
L
|
A
|
V
|
L
|
L
|
V
|
60 |
ICL1 | |||||||||
L
|
G
|
R
|
H
|
P
|
R
|
F
|
H
|
A
|
P
|
70 |
TM2 | |||||||||
M
|
F
|
L
|
L
|
L
|
G
|
S
|
L
|
T
|
L
|
80 |
S
|
D
|
L
|
L
|
A
|
G
|
A
|
A
|
Y
|
A
|
90 |
ECL1 | |||||||||
A
|
N
|
I
|
L
|
L
|
S
|
G
|
P
|
L
|
T
|
100 |
TM3 | |||||||||
L
|
K
|
L
|
S
|
P
|
A
|
L
|
W
|
F
|
A
|
110 |
R
|
E
|
G
|
G
|
V
|
F
|
V
|
A
|
L
|
T
|
120 |
A
|
S
|
V
|
L
|
S
|
L
|
L
|
A
|
I
|
A
|
130 |
L
|
E
|
R
|
S
|
L
|
T
|
M
|
A
|
R
|
R
|
140 |
ICL2 | TM4 | ||||||||
G
|
P
|
A
|
P
|
V
|
S
|
S
|
R
|
G
|
R
|
150 |
T
|
L
|
A
|
M
|
A
|
A
|
A
|
A
|
W
|
G
|
160 |
V
|
S
|
L
|
L
|
L
|
G
|
L
|
L
|
P
|
A
|
170 |
ECL2 | |||||||||
L
|
G
|
W
|
N
|
C
|
L
|
G
|
R
|
L
|
D
|
180 |
A
|
C
|
S
|
T
|
V
|
L
|
P
|
L
|
Y
|
A
|
190 |
TM5 | |||||||||
K
|
A
|
Y
|
V
|
L
|
F
|
C
|
V
|
L
|
A
|
200 |
F
|
V
|
G
|
I
|
L
|
A
|
A
|
I
|
C
|
A
|
210 |
L
|
Y
|
A
|
R
|
I
|
Y
|
C
|
Q
|
V
|
R
|
220 |
A
|
N
|
A
|
R
|
R
|
L
|
P
|
A
|
R
|
P
|
230 |
ICL3 | |||||||||
G
|
T
|
A
|
G
|
T
|
T
|
S
|
T
|
R
|
A
|
240 |
TM6 | |||||||||
R
|
R
|
K
|
P
|
R
|
S
|
L
|
A
|
L
|
L
|
250 |
R
|
T
|
L
|
S
|
V
|
V
|
L
|
L
|
A
|
F
|
260 |
V
|
A
|
C
|
W
|
G
|
P
|
L
|
F
|
L
|
L
|
270 |
L
|
L
|
L
|
D
|
V
|
A
|
C
|
P
|
A
|
R
|
280 |
ECL3 | TM7 | ||||||||
T
|
C
|
P
|
V
|
L
|
L
|
Q
|
A
|
D
|
P
|
290 |
F
|
L
|
G
|
L
|
A
|
M
|
A
|
N
|
S
|
L
|
300 |
L
|
N
|
P
|
I
|
I
|
Y
|
T
|
L
|
T
|
N
|
310 |
H8 | |||||||||
R
|
D
|
L
|
R
|
H
|
A
|
L
|
L
|
R
|
L
|
320 |
C-term | |||||||||
V
|
C
|
C
|
G
|
R
|
H
|
S
|
C
|
G
|
R
|
330 |
D
|
P
|
S
|
G
|
S
|
Q
|
Q
|
S
|
A
|
S
|
340 |
A
|
A
|
E
|
A
|
S
|
G
|
G
|
L
|
R
|
R
|
350 |
C
|
L
|
P
|
P
|
G
|
L
|
D
|
G
|
S
|
F
|
360 |
S
|
G
|
S
|
E
|
R
|
S
|
S
|
P
|
Q
|
R
|
370 |
D
|
G
|
L
|
D
|
T
|
S
|
G
|
S
|
T
|
G
|
380 |
S
|
P
|
G
|
A
|
P
|
T
|
A
|
A
|
R
|
T
|
390 |
L
|
V
|
S
|
E
|
P
|
A
|
A
|
D
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
sphingosylphosphorylcholine, sphingosine 1-phosphate, dihydrosphingosine 1-phosphate
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page