MRGPRX1 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JGF

RESOLUTION

2.7 Å

REFERENCE

10.1038/S41467-023-40705-Z

PUBLICATION DATE

Jan. 10, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

35 interactions (Click to see)

LIGANDS

bovine adrenal medulla peptide 8-22 - Agonist pubchem gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

bovine adrenal medulla peptide 8-22



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 F 61 2x39 G.H5 N 359 G.H5.24
Van-der-waals TM2 F 61 2x39 G.H5 N 359 G.H5.24
Hydrophobic ICL2 C 132 34x55 G.S1 L 34 G.S1.02
Hydrophobic ICL2 P 127 34x50 G.H5 L 351 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 L 351 G.H5.16
Polar ICL2 C 132 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 C 132 34x55 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 C 132 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 N 59 2x37 G.H5 E 357 G.H5.22
Hydrophobic TM3 R 120 3x50 G.H5 L 360 G.H5.25
Hydrophobic TM3 R 120 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 P 127 34x50 G.H5 K 347 G.H5.12
Polar ICL2 R 131 34x54 G.H5 M 353 G.H5.18
Hydrophobic ICL2 R 131 34x54 G.H5 M 353 G.H5.18
Van-der-waals ICL2 R 131 34x54 G.H5 M 353 G.H5.18
Polar ICL2 R 131 34x54 G.H5 N 354 G.H5.19
Hydrophobic ICL2 R 131 34x54 G.H5 N 354 G.H5.19
Van-der-waals ICL2 R 131 34x54 G.H5 N 354 G.H5.19
Aromatic TM2 F 61 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM2 F 61 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 Y 358 G.H5.23
Polar TM6 L 214 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM6 L 214 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 214 6x33 G.H5 L 360 G.H5.25
Hydrophobic TM3 V 124 3x54 G.H5 L 351 G.H5.16
Van-der-waals TM3 V 124 3x54 G.H5 L 351 G.H5.16
Hydrophobic ICL2 P 127 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 127 34x50 G.H5 I 350 G.H5.15
Ionic ICL2 R 131 34x54 G.H5 E 357 G.H5.22
Polar ICL2 R 131 34x54 G.H5 E 357 G.H5.22
Van-der-waals ICL2 R 131 34x54 G.H5 E 357 G.H5.22
Hydrophobic TM3 V 124 3x54 G.H5 L 355 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 355 G.H5.20
Polar ICL2 P 127 34x50 G.H5 N 354 G.H5.19
Hydrophobic ICL2 P 127 34x50 G.H5 N 354 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 N 354 G.H5.19
Hydrophobic TM6 R 213 6x32 G.H5 L 360 G.H5.25
Hydrophobic ICL2 R 131 34x54 G.H5 I 350 G.H5.15
Van-der-waals ICL2 R 131 34x54 G.H5 I 350 G.H5.15
Hydrophobic ICL2 I 128 34x51 G.H5 I 350 G.H5.15
Polar TM6 T 217 6x36 G.H5 N 359 G.H5.24
Hydrophobic TM6 T 217 6x36 G.H5 L 360 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.S3 V 194 G.S3.01
Polar TM3 S 123 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 S 123 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 S 123 3x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 I 128 34x51 G.H5 K 347 G.H5.12
Polar ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 C 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 214 6x33 G.H5 L 355 G.H5.20
Polar ICL2 R 134 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 134 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 134 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 S 123 3x53 G.H5 Y 358 G.H5.23
Van-der-waals TM3 S 123 3x53 G.H5 Y 358 G.H5.23
Polar ICL2 R 131 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 131 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 124 3x54 G.H5 L 360 G.H5.25
Van-der-waals TM7 Y 272 7x53 G.H5 N 359 G.H5.24
Polar ICL2 Y 130 34x53 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 Y 130 34x53 G.H5 Y 358 G.H5.23
Van-der-waals ICL2 Y 130 34x53 G.H5 Y 358 G.H5.23
Hydrophobic TM5 I 202 5x65 G.H5 L 355 G.H5.20
Polar ICL2 Y 130 34x53 G.H5 E 357 G.H5.22
Hydrophobic ICL2 Y 130 34x53 G.H5 E 357 G.H5.22
Van-der-waals ICL2 Y 130 34x53 G.H5 E 357 G.H5.22
Polar ICL2 H 133 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 133 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 133 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 I 218 6x37 G.H5 L 360 G.H5.25
Hydrophobic TM3 E 119 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 E 119 3x49 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 Y 130 34x53 G.H5 N 354 G.H5.19
Van-der-waals ICL2 Y 130 34x53 G.H5 N 354 G.H5.19
Hydrophobic TM7 G 276 7x57 G.H5 N 359 G.H5.24
Polar TM2 F 61 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM2 F 61 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM5 L 198 5x61 G.H5 L 360 G.H5.25
Polar TM2 A 60 2x38 G.H5 E 357 G.H5.22