β2-adrenoceptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

March 6, 2024

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol - Agonist pubchem

PHYSIOLOGICAL LIGANDS

(-)-noradrenaline, L-NOREPINEPHRINE, (-)-adrenaline, noradrenaline, Zn2+



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 Q 229 5x68 G.H5 I 383 G.H5.15
Polar TM3 I 135 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 135 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 135 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 138 - G.H5 I 382 G.H5.14
Hydrophobic ICL2 F 139 - G.S3 V 217 G.S3.01
Hydrophobic TM3 R 131 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 139 - G.H5 D 378 G.H5.10
Van-der-waals ICL2 F 139 - G.H5 D 378 G.H5.10
Hydrophobic TM5 V 222 5x61 G.H5 L 394 G.H5.26
Polar TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 229 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM6 A 271 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 A 271 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM6 T 274 6x36 G.H5 L 394 G.H5.26
Hydrophobic TM5 K 232 5x71 G.H5 I 383 G.H5.15
Hydrophobic TM5 Q 229 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 135 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 139 - G.H5 I 382 G.H5.14
Van-der-waals ICL2 F 139 - G.H5 I 382 G.H5.14
Hydrophobic ICL2 F 139 - G.S1 H 41 G.S1.02