Refined structure (8JSO) of Gs - TA1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2024-07-12

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 233 from structure (59.1%), 161 from model (40.9%)
Residue sidechains - 213 from structure (54.1%), 181 from model (45.9%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 L G.HN.10 AF2 AF2
G.HN 5 G G.HN.11 AF2 AF2
G.HN 6 N G.HN.22 AF2 AF2
G.HN 7 S G.HN.23 AF2 AF2
G.HN 8 K G.HN.24 AF2 AF2
G.HN 9 T G.HN.26 AF2 AF2
G.HN 10 E G.HN.27 AF2 AF2
G.HN 11 D G.HN.28 Structure AF2
G.HN 12 Q G.HN.29 Structure AF2
G.HN 13 R G.HN.30 Structure AF2
G.HN 14 N G.HN.31 Structure AF2
G.HN 15 E G.HN.32 Structure Structure
G.HN 16 E G.HN.33 Structure AF2
G.HN 17 K G.HN.34 Structure Structure
G.HN 18 A G.HN.35 Structure Structure
G.HN 19 Q G.HN.36 Structure AF2
G.HN 20 R G.HN.37 Structure AF2
G.HN 21 E G.HN.38 Structure Structure
G.HN 22 A G.HN.39 Structure AF2
G.HN 23 N G.HN.40 Structure AF2
G.HN 24 K G.HN.41 Structure Structure
G.HN 25 K G.HN.42 Structure AF2
G.HN 26 I G.HN.43 Structure Structure
G.HN 27 E G.HN.44 Structure Structure
G.HN 28 K G.HN.45 Structure Structure
G.HN 29 Q G.HN.46 Structure Structure
G.HN 30 L G.HN.47 Structure Structure
G.HN 31 Q G.HN.48 Structure Structure
G.HN 32 K G.HN.49 Structure Structure
G.HN 33 D G.HN.50 Structure Structure
G.HN 34 K G.HN.51 Structure Structure
G.HN 35 Q G.HN.52 Structure Structure
G.HN 36 V G.HN.53 Structure Structure
G.hns1 37 Y G.hns1.01 Structure Structure
G.hns1 38 R G.hns1.02 Structure Structure
G.hns1 39 A G.hns1.03 Structure Structure
G.S1 40 T G.S1.01 Structure Structure
G.S1 41 H G.S1.02 Structure Structure
G.S1 42 R G.S1.03 Structure Structure
G.S1 43 L G.S1.04 Structure Structure
G.S1 44 L G.S1.05 Structure Structure
G.S1 45 L G.S1.06 Structure Structure
G.S1 46 L G.S1.07 Structure Structure
G.s1h1 47 G G.s1h1.01 Structure Structure
G.s1h1 48 A G.s1h1.02 Structure Structure
G.s1h1 49 G G.s1h1.03 Structure AF2
G.s1h1 50 E G.s1h1.04 Structure AF2
G.s1h1 51 S G.s1h1.05 Structure Structure
G.s1h1 52 G G.s1h1.06 Structure Structure
G.H1 53 K G.H1.01 Structure Structure
G.H1 54 S G.H1.02 Structure Structure
G.H1 55 T G.H1.03 Structure Structure
G.H1 56 I G.H1.04 Structure Structure
G.H1 57 V G.H1.05 Structure Structure
G.H1 58 K G.H1.06 Structure Structure
G.H1 59 Q G.H1.07 Structure Structure
G.H1 60 M G.H1.08 Structure Structure
G.H1 61 R G.H1.09 Structure Structure
G.H1 62 I G.H1.10 AF2 AF2
G.H1 63 L G.H1.11 AF2 AF2
G.H1 64 H G.H1.12 AF2 AF2
G.h1ha 65 V G.h1ha.01 AF2 AF2
G.h1ha 66 N G.h1ha.02 AF2 AF2
G.h1ha 67 G G.h1ha.03 AF2 AF2
G.h1ha 68 F G.h1ha.04 AF2 AF2
G.h1ha 69 N G.h1ha.05 AF2 AF2
G.h1ha 70 G G.h1ha.06 AF2 AF2
G.h1ha 71 E G.h1ha.07 AF2 AF2
G.h1ha 72 G G.h1ha.08 AF2 AF2
G.h1ha 73 G G.h1ha.09 AF2 AF2
G.h1ha 74 E G.h1ha.10 AF2 AF2
G.h1ha 75 E G.h1ha.11 AF2 AF2
G.h1ha 76 D G.h1ha.12 AF2 AF2
G.h1ha 77 P G.h1ha.13 AF2 AF2
G.h1ha 78 Q G.h1ha.14 AF2 AF2
G.h1ha 79 A G.h1ha.15 AF2 AF2
G.h1ha 80 A G.h1ha.16 AF2 AF2
G.h1ha 81 R G.h1ha.17 AF2 AF2
G.h1ha 82 S G.h1ha.18 AF2 AF2
G.h1ha 83 N G.h1ha.19 AF2 AF2
G.h1ha 84 S G.h1ha.20 AF2 AF2
H.HA 85 D H.HA.01 AF2 AF2
H.HA 86 G H.HA.02 AF2 AF2
H.HA 87 E H.HA.03 AF2 AF2
H.HA 88 K H.HA.04 AF2 AF2
H.HA 89 A H.HA.05 AF2 AF2
H.HA 90 T H.HA.06 AF2 AF2
H.HA 91 K H.HA.07 AF2 AF2
H.HA 92 V H.HA.08 AF2 AF2
H.HA 93 Q H.HA.09 AF2 AF2
H.HA 94 D H.HA.10 AF2 AF2
H.HA 95 I H.HA.11 AF2 AF2
H.HA 96 K H.HA.12 AF2 AF2
H.HA 97 N H.HA.13 AF2 AF2
H.HA 98 N H.HA.14 AF2 AF2
H.HA 99 L H.HA.15 AF2 AF2
H.HA 100 K H.HA.16 AF2 AF2
H.HA 101 E H.HA.17 AF2 AF2
H.HA 102 A H.HA.18 AF2 AF2
H.HA 103 I H.HA.19 AF2 AF2
H.HA 104 E H.HA.20 AF2 AF2
H.HA 105 T H.HA.21 AF2 AF2
H.HA 106 I H.HA.22 AF2 AF2
H.HA 107 V H.HA.23 AF2 AF2
H.HA 108 A H.HA.24 AF2 AF2
H.HA 109 A H.HA.25 AF2 AF2
H.HA 110 M H.HA.26 AF2 AF2
H.HA 111 S H.HA.27 AF2 AF2
H.HA 112 N H.HA.28 AF2 AF2
H.HA 113 L H.HA.29 AF2 AF2
H.hahb 114 V H.hahb.01 AF2 AF2
H.hahb 115 P H.hahb.02 AF2 AF2
H.hahb 116 P H.hahb.03 AF2 AF2
H.hahb 117 V H.hahb.04 AF2 AF2
H.hahb 118 E H.hahb.05 AF2 AF2
H.hahb 119 L H.hahb.06 AF2 AF2
H.hahb 120 A H.hahb.07 AF2 AF2
H.hahb 121 N H.hahb.08 AF2 AF2
H.hahb 122 P H.hahb.09 AF2 AF2
H.HB 123 E H.HB.01 AF2 AF2
H.HB 124 N H.HB.02 AF2 AF2
H.HB 125 Q H.HB.03 AF2 AF2
H.HB 126 F H.HB.04 AF2 AF2
H.HB 127 R H.HB.05 AF2 AF2
H.HB 128 V H.HB.06 AF2 AF2
H.HB 129 D H.HB.07 AF2 AF2
H.HB 130 Y H.HB.08 AF2 AF2
H.HB 131 I H.HB.09 AF2 AF2
H.HB 132 L H.HB.10 AF2 AF2
H.HB 133 S H.HB.11 AF2 AF2
H.HB 134 V H.HB.12 AF2 AF2
H.HB 135 M H.HB.13 AF2 AF2
H.HB 136 N H.HB.14 AF2 AF2
H.hbhc 137 V H.hbhc.01 AF2 AF2
H.hbhc 138 P H.hbhc.02 AF2 AF2
H.hbhc 139 D H.hbhc.03 AF2 AF2
H.hbhc 140 F H.hbhc.04 AF2 AF2
H.hbhc 141 D H.hbhc.13 AF2 AF2
H.hbhc 142 F H.hbhc.14 AF2 AF2
H.hbhc 143 P H.hbhc.15 AF2 AF2
H.HC 144 P H.HC.01 AF2 AF2
H.HC 145 E H.HC.02 AF2 AF2
H.HC 146 F H.HC.03 AF2 AF2
H.HC 147 Y H.HC.04 AF2 AF2
H.HC 148 E H.HC.05 AF2 AF2
H.HC 149 H H.HC.06 AF2 AF2
H.HC 150 A H.HC.07 AF2 AF2
H.HC 151 K H.HC.08 AF2 AF2
H.HC 152 A H.HC.09 AF2 AF2
H.HC 153 L H.HC.10 AF2 AF2
H.HC 154 W H.HC.11 AF2 AF2
H.HC 155 E H.HC.12 AF2 AF2
H.hchd 156 D H.hchd.01 AF2 AF2
H.HD 157 E H.HD.01 AF2 AF2
H.HD 158 G H.HD.02 AF2 AF2
H.HD 159 V H.HD.03 AF2 AF2
H.HD 160 R H.HD.04 AF2 AF2
H.HD 161 A H.HD.05 AF2 AF2
H.HD 162 C H.HD.06 AF2 AF2
H.HD 163 Y H.HD.07 AF2 AF2
H.HD 164 E H.HD.08 AF2 AF2
H.HD 165 R H.HD.09 AF2 AF2
H.HD 166 S H.HD.10 AF2 AF2
H.HD 167 N H.HD.11 AF2 AF2
H.HD 168 E H.HD.12 AF2 AF2
H.hdhe 169 Y H.hdhe.01 AF2 AF2
H.hdhe 170 Q H.hdhe.02 AF2 AF2
H.hdhe 171 L H.hdhe.03 AF2 AF2
H.hdhe 172 I H.hdhe.04 AF2 AF2
H.hdhe 173 D H.hdhe.05 AF2 AF2
H.HE 174 C H.HE.01 AF2 AF2
H.HE 175 A H.HE.02 AF2 AF2
H.HE 176 Q H.HE.03 AF2 AF2
H.HE 177 Y H.HE.04 AF2 AF2
H.HE 178 F H.HE.05 AF2 AF2
H.HE 179 L H.HE.06 AF2 AF2
H.HE 180 D H.HE.07 AF2 AF2
H.HE 181 K H.HE.08 AF2 AF2
H.HE 182 I H.HE.09 AF2 AF2
H.HE 183 D H.HE.10 AF2 AF2
H.HE 184 V H.HE.11 AF2 AF2
H.HE 185 I H.HE.12 AF2 AF2
H.HE 186 K H.HE.13 AF2 AF2
H.hehf 187 Q H.hehf.01 AF2 AF2
H.hehf 188 A H.hehf.02 AF2 AF2
H.hehf 189 D H.hehf.03 AF2 AF2
H.hehf 190 Y H.hehf.04 AF2 AF2
H.hehf 191 V H.hehf.05 AF2 AF2
H.hehf 192 P H.hehf.06 AF2 AF2
H.hehf 193 S H.hehf.07 AF2 AF2
H.HF 194 D H.HF.01 AF2 AF2
H.HF 195 Q H.HF.02 AF2 AF2
H.HF 196 D H.HF.03 AF2 AF2
H.HF 197 L H.HF.04 AF2 AF2
H.HF 198 L H.HF.05 AF2 AF2
H.HF 199 R H.HF.06 AF2 AF2
G.hfs2 200 C G.hfs2.01 AF2 AF2
G.hfs2 201 R G.hfs2.02 AF2 AF2
G.hfs2 202 V G.hfs2.03 AF2 AF2
G.hfs2 203 L G.hfs2.04 Structure AF2
G.hfs2 204 T G.hfs2.05 Structure Structure
G.hfs2 205 S G.hfs2.06 Structure Structure
G.hfs2 206 G G.hfs2.07 Structure Structure
G.S2 207 I G.S2.01 Structure Structure
G.S2 208 F G.S2.02 Structure Structure
G.S2 209 E G.S2.03 Structure Structure
G.S2 210 T G.S2.04 Structure Structure
G.S2 211 K G.S2.05 Structure Structure
G.S2 212 F G.S2.06 Structure Structure
G.S2 213 Q G.S2.07 Structure Structure
G.S2 214 V G.S2.08 Structure Structure
G.s2s3 215 D G.s2s3.01 Structure Structure
G.s2s3 216 K G.s2s3.02 Structure Structure
G.S3 217 V G.S3.01 Structure Structure
G.S3 218 N G.S3.02 Structure Structure
G.S3 219 F G.S3.03 Structure Structure
G.S3 220 H G.S3.04 Structure Structure
G.S3 221 M G.S3.05 Structure Structure
G.S3 222 F G.S3.06 Structure Structure
G.S3 223 D G.S3.07 Structure Structure
G.S3 224 V G.S3.08 Structure Structure
G.s3h2 225 G G.s3h2.01 Structure Structure
G.s3h2 226 G G.s3h2.02 Structure AF2
G.s3h2 227 Q G.s3h2.03 Structure Structure
G.H2 228 R G.H2.01 Structure Structure
G.H2 229 D G.H2.02 Structure Structure
G.H2 230 E G.H2.03 Structure Structure
G.H2 231 R G.H2.04 Structure Structure
G.H2 232 R G.H2.05 Structure Structure
G.H2 233 K G.H2.06 Structure Structure
G.H2 234 W G.H2.07 Structure Structure
G.H2 235 I G.H2.08 Structure Structure
G.H2 236 Q G.H2.09 Structure Structure
G.H2 237 C G.H2.10 Structure Structure
G.h2s4 238 F G.h2s4.01 Structure Structure
G.h2s4 239 N G.h2s4.02 Structure Structure
G.h2s4 240 D G.h2s4.03 Structure Structure
G.h2s4 241 V G.h2s4.04 Structure Structure
G.h2s4 242 T G.h2s4.05 Structure Structure
G.S4 243 A G.S4.01 Structure Structure
G.S4 244 I G.S4.02 Structure Structure
G.S4 245 I G.S4.03 Structure Structure
G.S4 246 F G.S4.04 Structure Structure
G.S4 247 V G.S4.05 Structure Structure
G.S4 248 V G.S4.06 Structure Structure
G.S4 249 A G.S4.07 Structure AF2
G.s4h3 250 S G.s4h3.01 Structure Structure
G.s4h3 251 S G.s4h3.02 Structure Structure
G.s4h3 252 S G.s4h3.03 Structure AF2
G.s4h3 253 Y G.s4h3.04 Structure Structure
G.s4h3 254 N G.s4h3.05 Structure Structure
G.s4h3 255 M G.s4h3.06 AF2 AF2
G.s4h3 256 V G.s4h3.07 AF2 AF2
G.s4h3 257 I G.s4h3.08 AF2 AF2
G.s4h3 258 R G.s4h3.09 AF2 AF2
G.s4h3 259 E G.s4h3.10 AF2 AF2
G.s4h3 260 D G.s4h3.11 AF2 AF2
G.s4h3 261 N G.s4h3.12 AF2 AF2
G.s4h3 262 Q G.s4h3.13 AF2 AF2
G.s4h3 263 T G.s4h3.14 AF2 AF2
G.s4h3 264 N G.s4h3.15 AF2 AF2
G.H3 265 R G.H3.01 Structure Structure
G.H3 266 L G.H3.02 Structure Structure
G.H3 267 Q G.H3.03 Structure Structure
G.H3 268 E G.H3.04 Structure Structure
G.H3 269 A G.H3.05 Structure Structure
G.H3 270 L G.H3.06 Structure Structure
G.H3 271 N G.H3.07 Structure Structure
G.H3 272 L G.H3.08 Structure AF2
G.H3 273 F G.H3.09 Structure Structure
G.H3 274 K G.H3.10 Structure Structure
G.H3 275 S G.H3.11 Structure Structure
G.H3 276 I G.H3.12 Structure Structure
G.H3 277 W G.H3.13 Structure Structure
G.H3 278 N G.H3.14 Structure Structure
G.H3 279 N G.H3.15 Structure Structure
G.H3 280 R G.H3.16 Structure Structure
G.H3 281 W G.H3.17 Structure Structure
G.H3 282 L G.H3.18 Structure Structure
G.h3s5 283 R G.h3s5.01 Structure Structure
G.h3s5 284 T G.h3s5.02 Structure Structure
G.h3s5 285 I G.h3s5.03 Structure Structure
G.S5 286 S G.S5.01 Structure Structure
G.S5 287 V G.S5.02 Structure Structure
G.S5 288 I G.S5.03 Structure Structure
G.S5 289 L G.S5.04 Structure Structure
G.S5 290 F G.S5.05 Structure Structure
G.S5 291 L G.S5.06 Structure Structure
G.S5 292 N G.S5.07 Structure Structure
G.s5hg 293 K G.s5hg.01 Structure Structure
G.HG 294 Q G.HG.01 Structure Structure
G.HG 295 D G.HG.02 Structure Structure
G.HG 296 L G.HG.03 Structure Structure
G.HG 297 L G.HG.04 Structure Structure
G.HG 298 A G.HG.05 Structure Structure
G.HG 299 E G.HG.06 Structure Structure
G.HG 300 K G.HG.07 Structure Structure
G.HG 301 V G.HG.08 Structure Structure
G.HG 302 L G.HG.09 Structure Structure
G.HG 303 A G.HG.10 Structure Structure
G.HG 304 G G.HG.11 Structure Structure
G.HG 305 K G.HG.12 Structure Structure
G.HG 306 S G.HG.13 Structure Structure
G.HG 307 K G.HG.14 Structure Structure
G.HG 308 I G.HG.15 Structure Structure
G.HG 309 E G.HG.16 Structure Structure
G.HG 310 D G.HG.17 Structure Structure
G.hgh4 311 Y G.hgh4.01 Structure Structure
G.hgh4 312 F G.hgh4.02 Structure Structure
G.hgh4 313 P G.hgh4.03 Structure Structure
G.hgh4 314 E G.hgh4.04 Structure Structure
G.hgh4 315 F G.hgh4.05 Structure Structure
G.hgh4 316 A G.hgh4.06 Structure Structure
G.hgh4 317 R G.hgh4.07 Structure Structure
G.hgh4 318 Y G.hgh4.08 Structure Structure
G.hgh4 319 T G.hgh4.09 Structure Structure
G.hgh4 320 T G.hgh4.10 Structure Structure
G.hgh4 321 P G.hgh4.11 Structure Structure
G.hgh4 322 E G.hgh4.12 Structure Structure
G.hgh4 323 D G.hgh4.13 Structure Structure
G.hgh4 324 A G.hgh4.14 Structure Structure
G.hgh4 325 T G.hgh4.15 Structure Structure
G.hgh4 326 P G.hgh4.16 Structure Structure
G.hgh4 327 E G.hgh4.17 Structure Structure
G.hgh4 328 P G.hgh4.18 Structure Structure
G.hgh4 329 G G.hgh4.19 Structure Structure
G.hgh4 330 E G.hgh4.20 Structure Structure
G.hgh4 331 D G.hgh4.21 Structure Structure
G.H4 332 P G.H4.01 Structure Structure
G.H4 333 R G.H4.02 Structure Structure
G.H4 334 V G.H4.03 Structure Structure
G.H4 335 T G.H4.04 Structure Structure
G.H4 336 R G.H4.05 Structure Structure
G.H4 337 A G.H4.06 Structure Structure
G.H4 338 K G.H4.07 Structure Structure
G.H4 339 Y G.H4.08 Structure Structure
G.H4 340 F G.H4.10 Structure Structure
G.H4 341 I G.H4.11 Structure Structure
G.H4 342 R G.H4.12 Structure Structure
G.H4 343 D G.H4.13 Structure Structure
G.H4 344 E G.H4.14 Structure Structure
G.H4 345 F G.H4.15 Structure Structure
G.H4 346 L G.H4.16 Structure Structure
G.H4 347 R G.H4.17 Structure Structure
G.h4s6 348 I G.h4s6.01 Structure Structure
G.h4s6 349 S G.h4s6.02 Structure Structure
G.h4s6 350 T G.h4s6.03 Structure Structure
G.h4s6 351 A G.h4s6.04 Structure Structure
G.h4s6 352 S G.h4s6.08 Structure Structure
G.h4s6 353 G G.h4s6.09 Structure Structure
G.h4s6 354 D G.h4s6.10 Structure Structure
G.h4s6 355 G G.h4s6.11 Structure Structure
G.h4s6 356 R G.h4s6.12 Structure Structure
G.h4s6 357 H G.h4s6.13 Structure Structure
G.h4s6 358 Y G.h4s6.20 Structure Structure
G.S6 359 C G.S6.01 Structure Structure
G.S6 360 Y G.S6.02 Structure Structure
G.S6 361 P G.S6.03 Structure Structure
G.S6 362 H G.S6.04 Structure Structure
G.S6 363 F G.S6.05 Structure Structure
G.s6h5 364 T G.s6h5.01 Structure Structure
G.s6h5 365 C G.s6h5.02 Structure Structure
G.s6h5 366 A G.s6h5.03 Structure AF2
G.s6h5 367 V G.s6h5.04 Structure Structure
G.s6h5 368 D G.s6h5.05 Structure Structure
G.H5 369 T G.H5.01 Structure Structure
G.H5 370 E G.H5.02 Structure Structure
G.H5 371 N G.H5.03 Structure Structure
G.H5 372 I G.H5.04 Structure AF2
G.H5 373 R G.H5.05 Structure Structure
G.H5 374 R G.H5.06 Structure Structure
G.H5 375 V G.H5.07 Structure AF2
G.H5 376 F G.H5.08 Structure Structure
G.H5 377 N G.H5.09 Structure Structure
G.H5 378 D G.H5.10 Structure Structure
G.H5 379 C G.H5.11 Structure Structure
G.H5 380 R G.H5.12 Structure Structure
G.H5 381 D G.H5.13 Structure Structure
G.H5 382 I G.H5.14 Structure Structure
G.H5 383 I G.H5.15 Structure Structure
G.H5 384 Q G.H5.16 Structure Structure
G.H5 385 R G.H5.17 Structure Structure
G.H5 386 M G.H5.18 Structure Structure
G.H5 387 H G.H5.19 Structure Structure
G.H5 388 L G.H5.20 Structure Structure
G.H5 389 R G.H5.21 Structure Structure
G.H5 390 Q G.H5.22 Structure Structure
G.H5 391 Y G.H5.23 Structure Structure
G.H5 392 E G.H5.24 Structure Structure
G.H5 393 L G.H5.25 Structure Structure
G.H5 394 L G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 281 from structure (85.2%), 49 from model (14.8%)
Residue sidechains - 281 from structure (85.2%), 49 from model (14.8%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 M - AF2 AF2
N-term 3 P - AF2 AF2
N-term 4 F - AF2 AF2
N-term 5 C - AF2 AF2
N-term 6 H - AF2 AF2
N-term 7 N - AF2 AF2
N-term 8 I - AF2 AF2
N-term 9 I - AF2 AF2
N-term 10 N - AF2 AF2
N-term 11 I - AF2 AF2
N-term 12 S - AF2 AF2
N-term 13 C - AF2 AF2
N-term 14 V - AF2 AF2
N-term 15 K - AF2 AF2
N-term 16 N - AF2 AF2
N-term 17 N - AF2 AF2
N-term 18 W - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 N - AF2 AF2
TM1 21 D 1.30x30 Structure Structure
TM1 22 V 1.31x31 Structure Structure
TM1 23 R 1.32x32 Structure Structure
TM1 24 A 1.33x33 Structure Structure
TM1 25 S 1.34x34 Structure Structure
TM1 26 L 1.35x35 Structure Structure
TM1 27 Y 1.36x36 Structure Structure
TM1 28 S 1.37x37 Structure Structure
TM1 29 L 1.38x38 Structure Structure
TM1 30 M 1.39x39 Structure Structure
TM1 31 V 1.40x40 Structure Structure
TM1 32 L 1.41x41 Structure Structure
TM1 33 I 1.42x42 Structure Structure
TM1 34 I 1.43x43 Structure Structure
TM1 35 L 1.44x44 Structure Structure
TM1 36 T 1.45x45 Structure Structure
TM1 37 T 1.46x46 Structure Structure
TM1 38 L 1.47x47 Structure Structure
TM1 39 V 1.48x48 Structure Structure
TM1 40 G 1.49x49 Structure Structure
TM1 41 N 1.50x50 Structure Structure
TM1 42 L 1.51x51 Structure Structure
TM1 43 I 1.52x52 Structure Structure
TM1 44 V 1.53x53 Structure Structure
TM1 45 I 1.54x54 Structure Structure
TM1 46 V 1.55x55 Structure Structure
TM1 47 S 1.56x56 Structure Structure
TM1 48 I 1.57x57 Structure Structure
TM1 49 S 1.58x58 Structure Structure
TM1 50 H 1.59x59 Structure Structure
TM1 51 F 1.60x60 Structure Structure
ICL1 52 K 12.48x48 Structure Structure
ICL1 53 Q 12.49x49 Structure Structure
ICL1 54 L 12.50x50 Structure Structure
ICL1 55 H 12.51x51 Structure Structure
TM2 56 T 2.37x37 Structure Structure
TM2 57 P 2.38x38 Structure Structure
TM2 58 T 2.39x39 Structure Structure
TM2 59 N 2.40x40 Structure Structure
TM2 60 W 2.41x41 Structure Structure
TM2 61 L 2.42x42 Structure Structure
TM2 62 I 2.43x43 Structure Structure
TM2 63 H 2.44x44 Structure Structure
TM2 64 S 2.45x45 Structure Structure
TM2 65 M 2.46x46 Structure Structure
TM2 66 A 2.47x47 Structure Structure
TM2 67 T 2.48x48 Structure Structure
TM2 68 V 2.49x49 Structure Structure
TM2 69 D 2.50x50 Structure Structure
TM2 70 F 2.51x51 Structure Structure
TM2 71 L 2.52x52 Structure Structure
TM2 72 L 2.53x53 Structure Structure
TM2 73 G 2.54x54 Structure Structure
TM2 74 C 2.55x55 Structure Structure
TM2 75 L 2.56x551 Structure Structure
TM2 76 V 2.57x56 Structure Structure
TM2 77 M 2.58x57 Structure Structure
TM2 78 P 2.59x58 Structure Structure
TM2 79 Y 2.60x59 Structure Structure
TM2 80 S 2.61x60 Structure Structure
TM2 81 M 2.62x61 Structure Structure
TM2 82 V 2.63x62 Structure Structure
TM2 83 R 2.64x63 Structure Structure
TM2 84 S 2.65x64 Structure Structure
TM2 85 A 2.66x65 Structure Structure
TM2 86 E 2.67x66 Structure Structure
TM2 87 H 2.68x67 Structure Structure
ECL1 88 C 23.49x49 Structure Structure
ECL1 89 W 23.50x50 Structure Structure
ECL1 90 Y 23.51x51 Structure Structure
ECL1 91 F 23.52x52 Structure Structure
TM3 92 G 3.21x21 Structure Structure
TM3 93 E 3.22x22 Structure Structure
TM3 94 V 3.23x23 Structure Structure
TM3 95 F 3.24x24 Structure Structure
TM3 96 C 3.25x25 Structure Structure
TM3 97 K 3.26x26 Structure Structure
TM3 98 I 3.27x27 Structure Structure
TM3 99 H 3.28x28 Structure Structure
TM3 100 T 3.29x29 Structure Structure
TM3 101 S 3.30x30 Structure Structure
TM3 102 T 3.31x31 Structure Structure
TM3 103 D 3.32x32 Structure Structure
TM3 104 I 3.33x33 Structure Structure
TM3 105 M 3.34x34 Structure Structure
TM3 106 L 3.35x35 Structure Structure
TM3 107 S 3.36x36 Structure Structure
TM3 108 S 3.37x37 Structure Structure
TM3 109 A 3.38x38 Structure Structure
TM3 110 S 3.39x39 Structure Structure
TM3 111 I 3.40x40 Structure Structure
TM3 112 F 3.41x41 Structure Structure
TM3 113 H 3.42x42 Structure Structure
TM3 114 L 3.43x43 Structure Structure
TM3 115 S 3.44x44 Structure Structure
TM3 116 F 3.45x45 Structure Structure
TM3 117 I 3.46x46 Structure Structure
TM3 118 S 3.47x47 Structure Structure
TM3 119 I 3.48x48 Structure Structure
TM3 120 D 3.49x49 Structure Structure
TM3 121 R 3.50x50 Structure Structure
TM3 122 Y 3.51x51 Structure Structure
TM3 123 Y 3.52x52 Structure Structure
TM3 124 A 3.53x53 Structure Structure
TM3 125 V 3.54x54 Structure Structure
TM3 126 C 3.55x55 Structure Structure
TM3 127 D 3.56x56 Structure Structure
ICL2 128 P 34.50x50 Structure Structure
ICL2 129 L 34.51x51 Structure Structure
ICL2 130 R 34.52x52 Structure Structure
ICL2 131 Y 34.53x53 Structure Structure
ICL2 132 K 34.54x54 Structure Structure
ICL2 133 A 34.55x55 Structure Structure
ICL2 134 K 34.56x56 Structure Structure
ICL2 135 M 34.57x57 Structure Structure
TM4 136 N 4.38x38 Structure Structure
TM4 137 I 4.39x39 Structure Structure
TM4 138 L 4.40x40 Structure Structure
TM4 139 V 4.41x41 Structure Structure
TM4 140 I 4.42x42 Structure Structure
TM4 141 C 4.43x43 Structure Structure
TM4 142 V 4.44x44 Structure Structure
TM4 143 M 4.45x45 Structure Structure
TM4 144 I 4.46x46 Structure Structure
TM4 145 F 4.47x47 Structure Structure
TM4 146 I 4.48x48 Structure Structure
TM4 147 S 4.49x49 Structure Structure
TM4 148 W 4.50x50 Structure Structure
TM4 149 S 4.51x51 Structure Structure
TM4 150 V 4.52x52 Structure Structure
TM4 151 P 4.53x53 Structure Structure
TM4 152 A 4.54x54 Structure Structure
TM4 153 V 4.55x55 Structure Structure
TM4 154 F 4.56x56 Structure Structure
TM4 155 A 4.57x57 Structure Structure
TM4 156 F 4.58x58 Structure Structure
TM4 157 G 4.59x59 Structure Structure
TM4 158 M 4.60x60 Structure Structure
TM4 159 I 4.61x61 Structure Structure
TM4 160 F 4.62x62 Structure Structure
TM4 161 L 4.63x63 Structure Structure
TM4 162 E 4.64x64 Structure Structure
ECL2 163 L - Structure Structure
ECL2 164 N - Structure Structure
ECL2 165 F - Structure Structure
ECL2 166 K - Structure Structure
ECL2 167 G - Structure Structure
ECL2 168 A - Structure Structure
ECL2 169 E - Structure Structure
ECL2 170 E - Structure Structure
ECL2 171 I - Structure Structure
ECL2 172 Y - Structure Structure
ECL2 173 Y - Structure Structure
ECL2 174 K - Structure Structure
ECL2 175 H - Structure Structure
ECL2 176 V - Structure Structure
ECL2 177 H - Structure Structure
ECL2 178 C - Structure Structure
ECL2 179 R - Structure Structure
ECL2 180 G - Structure Structure
ECL2 181 G - Structure Structure
ECL2 182 C 45.50x50 Structure Structure
ECL2 183 S 45.51x51 Structure Structure
ECL2 184 V 45.52x52 Structure Structure
ECL2 185 F - Structure Structure
ECL2 186 F - Structure Structure
TM5 187 S 5.35x36 Structure Structure
TM5 188 K 5.36x37 Structure Structure
TM5 189 I 5.37x38 Structure Structure
TM5 190 S 5.38x39 Structure Structure
TM5 191 G 5.39x40 Structure Structure
TM5 192 V 5.40x41 Structure Structure
TM5 193 L 5.41x42 Structure Structure
TM5 194 T 5.42x43 Structure Structure
TM5 195 F 5.43x44 Structure Structure
TM5 196 M 5.44x45 Structure Structure
TM5 197 T 5.45x46 Structure Structure
TM5 198 S 5.46x461 Structure Structure
TM5 199 F 5.47x47 Structure Structure
TM5 200 Y 5.48x48 Structure Structure
TM5 201 I 5.49x49 Structure Structure
TM5 202 P 5.50x50 Structure Structure
TM5 203 G 5.51x51 Structure Structure
TM5 204 S 5.52x52 Structure Structure
TM5 205 I 5.53x53 Structure Structure
TM5 206 M 5.54x54 Structure Structure
TM5 207 L 5.55x55 Structure Structure
TM5 208 C 5.56x56 Structure Structure
TM5 209 V 5.57x57 Structure Structure
TM5 210 Y 5.58x58 Structure Structure
TM5 211 Y 5.59x59 Structure Structure
TM5 212 R 5.60x60 Structure Structure
TM5 213 I 5.61x61 Structure Structure
TM5 214 Y 5.62x62 Structure Structure
TM5 215 L 5.63x63 Structure Structure
TM5 216 I 5.64x64 Structure Structure
TM5 217 A 5.65x65 Structure Structure
TM5 218 K 5.66x66 Structure Structure
TM5 219 E 5.67x67 Structure Structure
TM5 220 Q 5.68x68 Structure Structure
TM5 221 A 5.69x69 Structure Structure
TM5 222 R 5.70x70 Structure Structure
TM5 223 L 5.71x71 Structure Structure
TM5 224 I 5.72x72 Structure Structure
TM5 225 S 5.73x73 Structure Structure
TM5 226 D 5.74x74 Structure Structure
TM5 227 A 5.75x75 Structure Structure
TM5 228 N 5.76x76 Structure Structure
TM5 229 Q 5.77x77 AF2 AF2
TM5 230 K 5.78x78 AF2 AF2
TM5 231 L 5.79x79 AF2 AF2
TM5 232 Q 5.80x80 AF2 AF2
ICL3 233 I - AF2 AF2
ICL3 234 G - AF2 AF2
ICL3 235 L - AF2 AF2
ICL3 236 E - AF2 AF2
ICL3 237 M - AF2 AF2
ICL3 238 K - AF2 AF2
TM6 239 N 6.23x23 AF2 AF2
TM6 240 G 6.24x24 AF2 AF2
TM6 241 I 6.25x25 AF2 AF2
TM6 242 S 6.26x26 AF2 AF2
TM6 243 Q 6.27x27 AF2 AF2
TM6 244 S 6.28x28 AF2 AF2
TM6 245 K 6.29x29 AF2 AF2
TM6 246 E 6.30x30 AF2 AF2
TM6 247 R 6.31x31 Structure Structure
TM6 248 K 6.32x32 Structure Structure
TM6 249 A 6.33x33 Structure Structure
TM6 250 V 6.34x34 Structure Structure
TM6 251 K 6.35x35 Structure Structure
TM6 252 T 6.36x36 Structure Structure
TM6 253 L 6.37x37 Structure Structure
TM6 254 G 6.38x38 Structure Structure
TM6 255 I 6.39x39 Structure Structure
TM6 256 V 6.40x40 Structure Structure
TM6 257 M 6.41x41 Structure Structure
TM6 258 G 6.42x42 Structure Structure
TM6 259 V 6.43x43 Structure Structure
TM6 260 F 6.44x44 Structure Structure
TM6 261 L 6.45x45 Structure Structure
TM6 262 I 6.46x46 Structure Structure
TM6 263 C 6.47x47 Structure Structure
TM6 264 W 6.48x48 Structure Structure
TM6 265 C 6.49x49 Structure Structure
TM6 266 P 6.50x50 Structure Structure
TM6 267 F 6.51x51 Structure Structure
TM6 268 F 6.52x52 Structure Structure
TM6 269 I 6.53x53 Structure Structure
TM6 270 C 6.54x54 Structure Structure
TM6 271 T 6.55x55 Structure Structure
TM6 272 V 6.56x56 Structure Structure
TM6 273 M 6.57x57 Structure Structure
TM6 274 D 6.58x58 Structure Structure
TM6 275 P 6.59x59 Structure Structure
TM6 276 F 6.60x60 Structure Structure
TM6 277 L 6.61x61 Structure Structure
ECL3 278 H - Structure Structure
ECL3 279 Y - Structure Structure
ECL3 280 I - Structure Structure
ECL3 281 I - Structure Structure
TM7 282 P 7.31x30 Structure Structure
TM7 283 P 7.32x31 Structure Structure
TM7 284 T 7.33x32 Structure Structure
TM7 285 L 7.34x33 Structure Structure
TM7 286 N 7.35x34 Structure Structure
TM7 287 D 7.36x35 Structure Structure
TM7 288 V 7.37x36 Structure Structure
TM7 289 L 7.38x37 Structure Structure
TM7 290 I 7.39x38 Structure Structure
TM7 291 W 7.40x39 Structure Structure
TM7 292 F 7.41x40 Structure Structure
TM7 293 G 7.42x41 Structure Structure
TM7 294 Y 7.43x42 Structure Structure
TM7 295 L 7.44x43 Structure Structure
TM7 296 N 7.45x45 Structure Structure
TM7 297 S 7.46x46 Structure Structure
TM7 298 T 7.47x47 Structure Structure
TM7 299 F 7.48x48 Structure Structure
TM7 300 N 7.49x49 Structure Structure
TM7 301 P 7.50x50 Structure Structure
TM7 302 M 7.51x51 Structure Structure
TM7 303 V 7.52x52 Structure Structure
TM7 304 Y 7.53x53 Structure Structure
TM7 305 A 7.54x54 Structure Structure
TM7 306 F 7.55x55 Structure Structure
TM7 307 F 7.56x56 Structure Structure
H8 308 Y 8.47x47 Structure Structure
H8 309 P 8.48x48 Structure Structure
H8 310 W 8.49x49 Structure Structure
H8 311 F 8.50x50 Structure Structure
H8 312 R 8.51x51 Structure Structure
H8 313 K 8.52x52 Structure Structure
H8 314 A 8.53x53 Structure Structure
H8 315 L 8.54x54 Structure Structure
H8 316 K 8.55x55 Structure Structure
H8 317 M 8.56x56 Structure Structure
H8 318 M 8.57x57 Structure Structure
H8 319 L 8.58x58 Structure Structure
H8 320 F 8.59x59 AF2 AF2
C-term 321 G - AF2 AF2
C-term 322 K - AF2 AF2
C-term 323 I - AF2 AF2
C-term 324 F - AF2 AF2
C-term 325 Q - AF2 AF2
C-term 326 K - AF2 AF2
C-term 327 D - AF2 AF2
C-term 328 S - AF2 AF2
C-term 329 S - AF2 AF2
C-term 330 R - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 217 5x65 G.H5 L 388 G.H5.20
Polar TM6 A 249 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 393 G.H5.25
Hydrophobic ICL2 L 129 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 129 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM5 I 224 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 224 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 129 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 P 128 34x50 G.H5 R 380 G.H5.12
Polar ICL2 K 132 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 132 34x54 G.hns1 R 38 G.hns1.02
Polar ICL3 G 234 - G.H4 R 347 G.H4.17
Hydrophobic TM3 V 125 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 V 125 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 129 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 I 224 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 224 5x72 G.h4s6 Y 358 G.h4s6.20
Ionic ICL2 R 130 34x52 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 130 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 130 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM5 L 231 5x79 G.H4 L 346 G.H4.16
Hydrophobic TM6 K 248 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 248 6x32 G.H5 L 394 G.H5.26
Polar ICL2 Y 131 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 130 34x52 G.S3 V 217 G.S3.01
Polar TM5 Q 220 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 Q 220 5x68 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 129 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM4 N 136 4x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM4 N 136 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM5 I 213 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 393 G.H5.25
Aromatic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 121 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 Q 220 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 231 5x79 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM5 L 231 5x79 G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 L 235 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 L 235 - G.h4s6 T 350 G.h4s6.03
Polar TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 Q 220 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 L 235 - G.H4 R 347 G.H4.17
Van-der-waals ICL3 L 235 - G.H4 R 347 G.H4.17
Ionic TM6 K 248 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 252 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 252 6x36 G.H5 E 392 G.H5.24
Polar ICL2 L 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 129 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 129 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 I 216 5x64 G.H5 L 388 G.H5.20
Hydrophobic H8 P 309 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 P 309 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 124 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 128 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Q 220 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 129 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 129 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM5 I 216 5x64 G.H5 Q 384 G.H5.16
Polar TM3 V 125 3x54 G.H5 Q 384 G.H5.16
Aromatic ICL2 Y 131 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 131 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 I 224 5x72 G.H5 L 394 G.H5.26
Ionic TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Polar TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM5 K 230 5x78 G.hgh4 D 323 G.hgh4.13
Polar TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 V 125 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 133 34x55 G.hns1 A 39 G.hns1.03