Refined structure (6OIJ) of G11 - M1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (62.7%), 134 from model (37.3%)
Residue sidechains - 188 from structure (52.4%), 171 from model (47.6%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 T G.HN.02 AF2 AF2
G.HN 3 L G.HN.03 AF2 AF2
G.HN 4 E G.HN.04 AF2 AF2
G.HN 5 S G.HN.05 AF2 AF2
G.HN 6 M G.HN.06 AF2 AF2
G.HN 7 M G.HN.07 AF2 AF2
G.HN 8 A G.HN.08 AF2 AF2
G.HN 9 C G.HN.09 Structure Structure
G.HN 10 C G.HN.10 Structure AF2
G.HN 11 L G.HN.11 Structure Structure
G.HN 12 S G.HN.30 Structure Structure
G.HN 13 D G.HN.31 Structure AF2
G.HN 14 E G.HN.32 Structure Structure
G.HN 15 V G.HN.33 Structure AF2
G.HN 16 K G.HN.34 Structure Structure
G.HN 17 E G.HN.35 Structure AF2
G.HN 18 S G.HN.36 Structure AF2
G.HN 19 K G.HN.37 Structure AF2
G.HN 20 R G.HN.38 Structure AF2
G.HN 21 I G.HN.39 Structure AF2
G.HN 22 N G.HN.40 Structure AF2
G.HN 23 A G.HN.41 Structure AF2
G.HN 24 E G.HN.42 Structure AF2
G.HN 25 I G.HN.43 Structure Structure
G.HN 26 E G.HN.44 Structure AF2
G.HN 27 K G.HN.45 Structure AF2
G.HN 28 Q G.HN.46 Structure AF2
G.HN 29 L G.HN.47 Structure Structure
G.HN 30 R G.HN.48 Structure Structure
G.HN 31 R G.HN.49 Structure AF2
G.HN 32 D G.HN.50 Structure Structure
G.HN 33 K G.HN.51 Structure AF2
G.HN 34 R G.HN.52 Structure AF2
G.HN 35 D G.HN.53 Structure AF2
G.hns1 36 A G.hns1.01 Structure Structure
G.hns1 37 R G.hns1.02 Structure Structure
G.hns1 38 R G.hns1.03 Structure Structure
G.S1 39 E G.S1.01 Structure Structure
G.S1 40 L G.S1.02 Structure Structure
G.S1 41 K G.S1.03 Structure Structure
G.S1 42 L G.S1.04 Structure Structure
G.S1 43 L G.S1.05 Structure Structure
G.S1 44 L G.S1.06 Structure Structure
G.S1 45 L G.S1.07 Structure Structure
G.s1h1 46 G G.s1h1.01 Structure Structure
G.s1h1 47 T G.s1h1.02 Structure Structure
G.s1h1 48 G G.s1h1.03 Structure Structure
G.s1h1 49 E G.s1h1.04 Structure AF2
G.s1h1 50 S G.s1h1.05 Structure Structure
G.s1h1 51 G G.s1h1.06 Structure Structure
G.H1 52 K G.H1.01 Structure Structure
G.H1 53 S G.H1.02 Structure Structure
G.H1 54 T G.H1.03 Structure Structure
G.H1 55 F G.H1.04 Structure Structure
G.H1 56 I G.H1.05 Structure Structure
G.H1 57 K G.H1.06 Structure Structure
G.H1 58 Q G.H1.07 Structure Structure
G.H1 59 M G.H1.08 Structure Structure
G.H1 60 R G.H1.09 Structure AF2
G.H1 61 I G.H1.10 Structure AF2
G.H1 62 I G.H1.11 Structure AF2
G.H1 63 H G.H1.12 Structure Structure
G.h1ha 64 G G.h1ha.01 Structure Structure
G.h1ha 65 A G.h1ha.02 AF2 AF2
G.h1ha 66 G G.h1ha.03 AF2 AF2
G.h1ha 67 Y G.h1ha.04 AF2 AF2
G.h1ha 68 S G.h1ha.05 AF2 AF2
H.HA 69 E H.HA.01 AF2 AF2
H.HA 70 E H.HA.02 AF2 AF2
H.HA 71 D H.HA.03 AF2 AF2
H.HA 72 K H.HA.04 AF2 AF2
H.HA 73 R H.HA.05 AF2 AF2
H.HA 74 G H.HA.06 AF2 AF2
H.HA 75 F H.HA.07 AF2 AF2
H.HA 76 T H.HA.08 AF2 AF2
H.HA 77 K H.HA.09 AF2 AF2
H.HA 78 L H.HA.10 AF2 AF2
H.HA 79 V H.HA.11 AF2 AF2
H.HA 80 Y H.HA.12 AF2 AF2
H.HA 81 Q H.HA.13 AF2 AF2
H.HA 82 N H.HA.14 AF2 AF2
H.HA 83 I H.HA.15 AF2 AF2
H.HA 84 F H.HA.16 AF2 AF2
H.HA 85 T H.HA.17 AF2 AF2
H.HA 86 A H.HA.18 AF2 AF2
H.HA 87 M H.HA.19 AF2 AF2
H.HA 88 Q H.HA.20 AF2 AF2
H.HA 89 A H.HA.21 AF2 AF2
H.HA 90 M H.HA.22 AF2 AF2
H.HA 91 I H.HA.23 AF2 AF2
H.HA 92 R H.HA.24 AF2 AF2
H.HA 93 A H.HA.25 AF2 AF2
H.HA 94 M H.HA.26 AF2 AF2
H.HA 95 E H.HA.27 AF2 AF2
H.HA 96 T H.HA.28 AF2 AF2
H.HA 97 L H.HA.29 AF2 AF2
H.hahb 98 K H.hahb.01 AF2 AF2
H.hahb 99 I H.hahb.04 AF2 AF2
H.hahb 100 L H.hahb.05 AF2 AF2
H.hahb 101 Y H.hahb.06 AF2 AF2
H.hahb 102 K H.hahb.07 AF2 AF2
H.hahb 103 Y H.hahb.08 AF2 AF2
H.hahb 104 E H.hahb.09 AF2 AF2
H.HB 105 Q H.HB.01 AF2 AF2
H.HB 106 N H.HB.02 AF2 AF2
H.HB 107 K H.HB.03 AF2 AF2
H.HB 108 A H.HB.04 AF2 AF2
H.HB 109 N H.HB.05 AF2 AF2
H.HB 110 A H.HB.06 AF2 AF2
H.HB 111 L H.HB.07 AF2 AF2
H.HB 112 L H.HB.08 AF2 AF2
H.HB 113 I H.HB.09 AF2 AF2
H.HB 114 R H.HB.10 AF2 AF2
H.HB 115 E H.HB.11 AF2 AF2
H.HB 116 V H.HB.12 AF2 AF2
H.HB 117 D H.HB.13 AF2 AF2
H.HB 118 V H.HB.14 AF2 AF2
H.hbhc 119 E H.hbhc.01 AF2 AF2
H.hbhc 120 K H.hbhc.02 AF2 AF2
H.hbhc 121 V H.hbhc.03 AF2 AF2
H.hbhc 122 T H.hbhc.04 AF2 AF2
H.hbhc 123 T H.hbhc.05 AF2 AF2
H.hbhc 124 F H.hbhc.14 AF2 AF2
H.hbhc 125 E H.hbhc.15 AF2 AF2
H.HC 126 H H.HC.01 AF2 AF2
H.HC 127 Q H.HC.02 AF2 AF2
H.HC 128 Y H.HC.03 AF2 AF2
H.HC 129 V H.HC.04 AF2 AF2
H.HC 130 S H.HC.05 AF2 AF2
H.HC 131 A H.HC.06 AF2 AF2
H.HC 132 I H.HC.07 AF2 AF2
H.HC 133 K H.HC.08 AF2 AF2
H.HC 134 T H.HC.09 AF2 AF2
H.HC 135 L H.HC.10 AF2 AF2
H.HC 136 W H.HC.11 AF2 AF2
H.HC 137 E H.HC.12 AF2 AF2
H.hchd 138 D H.hchd.01 AF2 AF2
H.HD 139 P H.HD.01 AF2 AF2
H.HD 140 G H.HD.02 AF2 AF2
H.HD 141 I H.HD.03 AF2 AF2
H.HD 142 Q H.HD.04 AF2 AF2
H.HD 143 E H.HD.05 AF2 AF2
H.HD 144 C H.HD.06 AF2 AF2
H.HD 145 Y H.HD.07 AF2 AF2
H.HD 146 D H.HD.08 AF2 AF2
H.HD 147 R H.HD.09 AF2 AF2
H.HD 148 R H.HD.10 AF2 AF2
H.HD 149 R H.HD.11 AF2 AF2
H.HD 150 E H.HD.12 AF2 AF2
H.hdhe 151 Y H.hdhe.01 AF2 AF2
H.hdhe 152 Q H.hdhe.02 AF2 AF2
H.hdhe 153 L H.hdhe.03 AF2 AF2
H.hdhe 154 S H.hdhe.04 AF2 AF2
H.hdhe 155 D H.hdhe.05 AF2 AF2
H.HE 156 S H.HE.01 AF2 AF2
H.HE 157 A H.HE.02 AF2 AF2
H.HE 158 K H.HE.03 AF2 AF2
H.HE 159 Y H.HE.04 AF2 AF2
H.HE 160 Y H.HE.05 AF2 AF2
H.HE 161 L H.HE.06 AF2 AF2
H.HE 162 T H.HE.07 AF2 AF2
H.HE 163 D H.HE.08 AF2 AF2
H.HE 164 V H.HE.09 AF2 AF2
H.HE 165 D H.HE.10 AF2 AF2
H.HE 166 R H.HE.11 AF2 AF2
H.HE 167 I H.HE.12 AF2 AF2
H.HE 168 A H.HE.13 AF2 AF2
H.hehf 169 T H.hehf.01 AF2 AF2
H.hehf 170 L H.hehf.02 AF2 AF2
H.hehf 171 G H.hehf.03 AF2 AF2
H.hehf 172 Y H.hehf.04 AF2 AF2
H.hehf 173 L H.hehf.05 AF2 AF2
H.hehf 174 P H.hehf.06 AF2 AF2
H.hehf 175 T H.hehf.07 AF2 AF2
H.HF 176 Q H.HF.01 AF2 AF2
H.HF 177 Q H.HF.02 AF2 AF2
H.HF 178 D H.HF.03 AF2 AF2
H.HF 179 V H.HF.04 AF2 AF2
H.HF 180 L H.HF.05 AF2 AF2
H.HF 181 R H.HF.06 AF2 AF2
G.hfs2 182 V G.hfs2.01 AF2 AF2
G.hfs2 183 R G.hfs2.02 AF2 AF2
G.hfs2 184 V G.hfs2.03 AF2 AF2
G.hfs2 185 P G.hfs2.04 AF2 AF2
G.hfs2 186 T G.hfs2.05 AF2 AF2
G.hfs2 187 T G.hfs2.06 Structure Structure
G.hfs2 188 G G.hfs2.07 Structure Structure
G.S2 189 I G.S2.01 Structure Structure
G.S2 190 I G.S2.02 Structure Structure
G.S2 191 E G.S2.03 Structure Structure
G.S2 192 Y G.S2.04 Structure Structure
G.S2 193 P G.S2.05 Structure Structure
G.S2 194 F G.S2.06 Structure Structure
G.S2 195 D G.S2.07 Structure Structure
G.S2 196 L G.S2.08 Structure Structure
G.s2s3 197 E G.s2s3.01 Structure AF2
G.s2s3 198 N G.s2s3.02 Structure Structure
G.S3 199 I G.S3.01 Structure Structure
G.S3 200 I G.S3.02 Structure Structure
G.S3 201 F G.S3.03 Structure Structure
G.S3 202 R G.S3.04 Structure Structure
G.S3 203 M G.S3.05 Structure Structure
G.S3 204 V G.S3.06 Structure Structure
G.S3 205 D G.S3.07 Structure Structure
G.S3 206 V G.S3.08 Structure Structure
G.s3h2 207 G G.s3h2.01 Structure Structure
G.s3h2 208 G G.s3h2.02 Structure Structure
G.s3h2 209 Q G.s3h2.03 Structure Structure
G.H2 210 R G.H2.01 Structure AF2
G.H2 211 S G.H2.02 Structure Structure
G.H2 212 E G.H2.03 Structure Structure
G.H2 213 R G.H2.04 Structure Structure
G.H2 214 R G.H2.05 Structure Structure
G.H2 215 K G.H2.06 Structure Structure
G.H2 216 W G.H2.07 Structure Structure
G.H2 217 I G.H2.08 Structure Structure
G.H2 218 H G.H2.09 Structure Structure
G.H2 219 C G.H2.10 Structure Structure
G.h2s4 220 F G.h2s4.01 Structure Structure
G.h2s4 221 E G.h2s4.02 Structure Structure
G.h2s4 222 N G.h2s4.03 Structure Structure
G.h2s4 223 V G.h2s4.04 Structure Structure
G.h2s4 224 T G.h2s4.05 Structure Structure
G.S4 225 S G.S4.01 Structure Structure
G.S4 226 I G.S4.02 Structure Structure
G.S4 227 M G.S4.03 Structure Structure
G.S4 228 F G.S4.04 Structure Structure
G.S4 229 L G.S4.05 Structure Structure
G.S4 230 V G.S4.06 Structure Structure
G.S4 231 A G.S4.07 Structure Structure
G.s4h3 232 L G.s4h3.01 Structure Structure
G.s4h3 233 S G.s4h3.02 Structure Structure
G.s4h3 234 E G.s4h3.03 Structure AF2
G.s4h3 235 Y G.s4h3.04 Structure Structure
G.s4h3 236 D G.s4h3.05 Structure Structure
G.s4h3 237 Q G.s4h3.06 Structure AF2
G.s4h3 238 V G.s4h3.07 Structure AF2
G.s4h3 239 L G.s4h3.08 AF2 AF2
G.s4h3 240 V G.s4h3.09 AF2 AF2
G.s4h3 241 E G.s4h3.10 AF2 AF2
G.s4h3 242 S G.s4h3.11 AF2 AF2
G.s4h3 243 D G.s4h3.12 Structure AF2
G.s4h3 244 N G.s4h3.13 Structure AF2
G.s4h3 245 E G.s4h3.14 Structure AF2
G.s4h3 246 N G.s4h3.15 Structure Structure
G.H3 247 R G.H3.01 Structure Structure
G.H3 248 M G.H3.02 Structure Structure
G.H3 249 E G.H3.03 Structure Structure
G.H3 250 E G.H3.04 Structure AF2
G.H3 251 S G.H3.05 Structure Structure
G.H3 252 K G.H3.06 Structure Structure
G.H3 253 A G.H3.07 Structure Structure
G.H3 254 L G.H3.08 Structure Structure
G.H3 255 F G.H3.09 Structure Structure
G.H3 256 R G.H3.10 Structure Structure
G.H3 257 T G.H3.11 Structure Structure
G.H3 258 I G.H3.12 Structure Structure
G.H3 259 I G.H3.13 Structure Structure
G.H3 260 T G.H3.14 Structure Structure
G.H3 261 Y G.H3.15 Structure Structure
G.H3 262 P G.H3.16 Structure Structure
G.H3 263 W G.H3.17 Structure Structure
G.H3 264 F G.H3.18 Structure Structure
G.h3s5 265 Q G.h3s5.01 Structure Structure
G.h3s5 266 N G.h3s5.02 Structure Structure
G.h3s5 267 S G.h3s5.03 Structure Structure
G.S5 268 S G.S5.01 Structure Structure
G.S5 269 V G.S5.02 Structure Structure
G.S5 270 I G.S5.03 Structure Structure
G.S5 271 L G.S5.04 Structure Structure
G.S5 272 F G.S5.05 Structure Structure
G.S5 273 L G.S5.06 Structure Structure
G.S5 274 N G.S5.07 Structure Structure
G.s5hg 275 K G.s5hg.01 Structure Structure
G.HG 276 K G.HG.01 Structure Structure
G.HG 277 D G.HG.02 Structure AF2
G.HG 278 L G.HG.03 Structure AF2
G.HG 279 L G.HG.04 Structure Structure
G.HG 280 E G.HG.05 Structure Structure
G.HG 281 D G.HG.06 Structure Structure
G.HG 282 K G.HG.07 Structure Structure
G.HG 283 I G.HG.08 Structure Structure
G.HG 284 L G.HG.09 Structure Structure
G.HG 285 Y G.HG.12 Structure Structure
G.HG 286 S G.HG.13 Structure Structure
G.HG 287 H G.HG.14 Structure Structure
G.HG 288 L G.HG.15 Structure Structure
G.HG 289 V G.HG.16 Structure Structure
G.HG 290 D G.HG.17 Structure Structure
G.hgh4 291 Y G.hgh4.01 Structure Structure
G.hgh4 292 F G.hgh4.02 Structure Structure
G.hgh4 293 P G.hgh4.03 Structure Structure
G.hgh4 294 E G.hgh4.04 Structure Structure
G.hgh4 295 F G.hgh4.05 Structure Structure
G.hgh4 296 D G.hgh4.06 Structure Structure
G.hgh4 297 G G.hgh4.07 Structure Structure
G.hgh4 298 P G.hgh4.08 Structure Structure
G.H4 299 Q G.H4.01 Structure Structure
G.H4 300 R G.H4.02 Structure Structure
G.H4 301 D G.H4.03 Structure Structure
G.H4 302 A G.H4.04 Structure Structure
G.H4 303 Q G.H4.05 Structure Structure
G.H4 304 A G.H4.06 Structure Structure
G.H4 305 A G.H4.07 Structure Structure
G.H4 306 R G.H4.08 Structure Structure
G.H4 307 E G.H4.09 Structure Structure
G.H4 308 F G.H4.10 Structure Structure
G.H4 309 I G.H4.11 Structure Structure
G.H4 310 L G.H4.12 Structure Structure
G.H4 311 K G.H4.13 Structure Structure
G.H4 312 M G.H4.14 Structure Structure
G.H4 313 F G.H4.15 Structure Structure
G.H4 314 V G.H4.16 Structure Structure
G.H4 315 D G.H4.17 Structure Structure
G.h4s6 316 L G.h4s6.01 Structure Structure
G.h4s6 317 N G.h4s6.08 Structure AF2
G.h4s6 318 P G.h4s6.09 Structure Structure
G.h4s6 319 D G.h4s6.10 Structure AF2
G.h4s6 320 S G.h4s6.11 Structure AF2
G.h4s6 321 D G.h4s6.12 Structure Structure
G.h4s6 322 K G.h4s6.13 Structure Structure
G.h4s6 323 I G.h4s6.20 Structure Structure
G.S6 324 I G.S6.01 Structure Structure
G.S6 325 Y G.S6.02 Structure Structure
G.S6 326 S G.S6.03 Structure Structure
G.S6 327 H G.S6.04 Structure Structure
G.S6 328 F G.S6.05 Structure Structure
G.s6h5 329 T G.s6h5.01 Structure Structure
G.s6h5 330 C G.s6h5.02 Structure Structure
G.s6h5 331 A G.s6h5.03 Structure Structure
G.s6h5 332 T G.s6h5.04 Structure Structure
G.s6h5 333 D G.s6h5.05 Structure Structure
G.H5 334 T G.H5.01 Structure Structure
G.H5 335 E G.H5.02 Structure AF2
G.H5 336 N G.H5.03 Structure Structure
G.H5 337 I G.H5.04 Structure Structure
G.H5 338 R G.H5.05 Structure Structure
G.H5 339 F G.H5.06 Structure Structure
G.H5 340 V G.H5.07 Structure Structure
G.H5 341 F G.H5.08 Structure Structure
G.H5 342 A G.H5.09 Structure Structure
G.H5 343 A G.H5.10 Structure Structure
G.H5 344 V G.H5.11 Structure Structure
G.H5 345 K G.H5.12 Structure Structure
G.H5 346 D G.H5.13 Structure Structure
G.H5 347 T G.H5.14 Structure Structure
G.H5 348 I G.H5.15 Structure Structure
G.H5 349 L G.H5.16 Structure Structure
G.H5 350 Q G.H5.17 Structure Structure
G.H5 351 L G.H5.18 Structure Structure
G.H5 352 N G.H5.19 Structure Structure
G.H5 353 L G.H5.20 Structure Structure
G.H5 354 K G.H5.21 Structure Structure
G.H5 355 E G.H5.22 Structure Structure
G.H5 356 Y G.H5.23 Structure Structure
G.H5 357 N G.H5.24 Structure Structure
G.H5 358 L G.H5.25 Structure Structure
G.H5 359 V G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 291 from structure (87.9%), 40 from model (12.1%)
Residue sidechains - 270 from structure (81.6%), 61 from model (18.4%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 S - AF2 AF2
N-term 5 A - AF2 AF2
N-term 6 P - AF2 AF2
N-term 7 P - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 V - AF2 AF2
N-term 10 S - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 N - AF2 AF2
N-term 13 I - AF2 AF2
N-term 14 T - AF2 AF2
N-term 15 V - AF2 AF2
N-term 16 L - AF2 AF2
N-term 17 A - AF2 AF2
N-term 18 P - AF2 AF2
N-term 19 G - AF2 AF2
N-term 20 K - AF2 AF2
TM1 21 G 1.28x28 AF2 AF2
TM1 22 P 1.29x29 AF2 AF2
TM1 23 W 1.30x30 Structure Structure
TM1 24 Q 1.31x31 Structure AF2
TM1 25 V 1.32x32 Structure Structure
TM1 26 A 1.33x33 Structure Structure
TM1 27 F 1.34x34 Structure Structure
TM1 28 I 1.35x35 Structure Structure
TM1 29 G 1.36x36 Structure Structure
TM1 30 I 1.37x37 Structure AF2
TM1 31 T 1.38x38 Structure Structure
TM1 32 T 1.39x39 Structure Structure
TM1 33 G 1.40x40 Structure Structure
TM1 34 L 1.41x41 Structure Structure
TM1 35 L 1.42x42 Structure Structure
TM1 36 S 1.43x43 Structure Structure
TM1 37 L 1.44x44 Structure Structure
TM1 38 A 1.45x45 Structure Structure
TM1 39 T 1.46x46 Structure Structure
TM1 40 V 1.47x47 Structure Structure
TM1 41 T 1.48x48 Structure Structure
TM1 42 G 1.49x49 Structure Structure
TM1 43 N 1.50x50 Structure Structure
TM1 44 L 1.51x51 Structure Structure
TM1 45 L 1.52x52 Structure Structure
TM1 46 V 1.53x53 Structure Structure
TM1 47 L 1.54x54 Structure Structure
TM1 48 I 1.55x55 Structure Structure
TM1 49 S 1.56x56 Structure Structure
TM1 50 F 1.57x57 Structure Structure
TM1 51 K 1.58x58 Structure Structure
TM1 52 V 1.59x59 Structure Structure
TM1 53 N 1.60x60 Structure Structure
ICL1 54 T 12.48x48 Structure Structure
ICL1 55 E 12.49x49 Structure AF2
ICL1 56 L 12.50x50 Structure Structure
ICL1 57 K 12.51x51 Structure Structure
TM2 58 T 2.37x37 Structure Structure
TM2 59 V 2.38x38 Structure Structure
TM2 60 N 2.39x39 Structure Structure
TM2 61 N 2.40x40 Structure Structure
TM2 62 Y 2.41x41 Structure Structure
TM2 63 F 2.42x42 Structure Structure
TM2 64 L 2.43x43 Structure Structure
TM2 65 L 2.44x44 Structure Structure
TM2 66 S 2.45x45 Structure Structure
TM2 67 L 2.46x46 Structure Structure
TM2 68 A 2.47x47 Structure Structure
TM2 69 C 2.48x48 Structure Structure
TM2 70 A 2.49x49 Structure Structure
TM2 71 D 2.50x50 Structure Structure
TM2 72 L 2.51x51 Structure Structure
TM2 73 I 2.52x52 Structure Structure
TM2 74 I 2.53x53 Structure Structure
TM2 75 G 2.54x54 Structure Structure
TM2 76 T 2.55x55 Structure Structure
TM2 77 F 2.56x551 Structure Structure
TM2 78 S 2.57x56 Structure Structure
TM2 79 M 2.58x57 Structure Structure
TM2 80 N 2.59x58 Structure Structure
TM2 81 L 2.60x59 Structure Structure
TM2 82 Y 2.61x60 Structure Structure
TM2 83 T 2.62x61 Structure Structure
TM2 84 T 2.63x62 Structure Structure
TM2 85 Y 2.64x63 Structure Structure
TM2 86 L 2.65x64 Structure Structure
TM2 87 L 2.66x65 Structure Structure
TM2 88 M 2.67x66 Structure Structure
TM2 89 G 2.68x67 Structure Structure
ECL1 90 H 23.49x49 Structure Structure
ECL1 91 W 23.50x50 Structure Structure
ECL1 92 A 23.51x51 Structure Structure
ECL1 93 L 23.52x52 Structure Structure
TM3 94 G 3.21x21 Structure Structure
TM3 95 T 3.22x22 Structure Structure
TM3 96 L 3.23x23 Structure Structure
TM3 97 A 3.24x24 Structure Structure
TM3 98 C 3.25x25 Structure Structure
TM3 99 D 3.26x26 Structure AF2
TM3 100 L 3.27x27 Structure Structure
TM3 101 W 3.28x28 Structure Structure
TM3 102 L 3.29x29 Structure Structure
TM3 103 A 3.30x30 Structure Structure
TM3 104 L 3.31x31 Structure Structure
TM3 105 D 3.32x32 Structure Structure
TM3 106 Y 3.33x33 Structure Structure
TM3 107 V 3.34x34 Structure Structure
TM3 108 A 3.35x35 Structure Structure
TM3 109 S 3.36x36 Structure Structure
TM3 110 N 3.37x37 Structure AF2
TM3 111 A 3.38x38 Structure Structure
TM3 112 S 3.39x39 Structure Structure
TM3 113 V 3.40x40 Structure Structure
TM3 114 M 3.41x41 Structure Structure
TM3 115 N 3.42x42 Structure Structure
TM3 116 L 3.43x43 Structure Structure
TM3 117 L 3.44x44 Structure Structure
TM3 118 L 3.45x45 Structure Structure
TM3 119 I 3.46x46 Structure Structure
TM3 120 S 3.47x47 Structure Structure
TM3 121 F 3.48x48 Structure Structure
TM3 122 D 3.49x49 Structure Structure
TM3 123 R 3.50x50 Structure Structure
TM3 124 Y 3.51x51 Structure Structure
TM3 125 F 3.52x52 Structure Structure
TM3 126 S 3.53x53 Structure Structure
TM3 127 V 3.54x54 Structure Structure
TM3 128 T 3.55x55 Structure Structure
TM3 129 R 3.56x56 Structure Structure
ICL2 130 P 34.50x50 Structure Structure
ICL2 131 L 34.51x51 Structure Structure
ICL2 132 S 34.52x52 Structure Structure
ICL2 133 Y 34.53x53 Structure Structure
ICL2 134 R 34.54x54 Structure Structure
ICL2 135 A 34.55x55 Structure Structure
ICL2 136 K 34.56x56 Structure Structure
ICL2 137 R 34.57x57 Structure Structure
TM4 138 T 4.38x38 Structure Structure
TM4 139 P 4.39x39 Structure Structure
TM4 140 R 4.40x40 Structure AF2
TM4 141 R 4.41x41 Structure Structure
TM4 142 A 4.42x42 Structure Structure
TM4 143 A 4.43x43 Structure Structure
TM4 144 L 4.44x44 Structure Structure
TM4 145 M 4.45x45 Structure Structure
TM4 146 I 4.46x46 Structure Structure
TM4 147 G 4.47x47 Structure Structure
TM4 148 L 4.48x48 Structure Structure
TM4 149 A 4.49x49 Structure Structure
TM4 150 W 4.50x50 Structure Structure
TM4 151 L 4.51x51 Structure Structure
TM4 152 V 4.52x52 Structure Structure
TM4 153 S 4.53x53 Structure Structure
TM4 154 F 4.54x54 Structure Structure
TM4 155 V 4.55x55 Structure Structure
TM4 156 L 4.56x56 Structure Structure
TM4 157 W 4.57x57 Structure Structure
TM4 158 A 4.58x58 Structure Structure
TM4 159 P 4.59x59 Structure Structure
TM4 160 A 4.60x60 Structure Structure
TM4 161 I 4.61x61 Structure Structure
TM4 162 L 4.62x62 Structure Structure
TM4 163 F 4.63x63 Structure Structure
TM4 164 W 4.64x64 Structure Structure
TM4 165 Q 4.65x65 Structure Structure
TM4 166 Y 4.66x66 Structure Structure
TM4 167 L 4.67x67 Structure Structure
TM4 168 V 4.68x68 Structure AF2
TM4 169 G 4.69x69 Structure Structure
ECL2 170 E - Structure AF2
ECL2 171 R - Structure Structure
ECL2 172 T - Structure Structure
ECL2 173 V - Structure Structure
ECL2 174 L - Structure Structure
ECL2 175 A - Structure Structure
ECL2 176 G - Structure Structure
ECL2 177 Q - Structure Structure
ECL2 178 C 45.50x50 Structure Structure
ECL2 179 Y 45.51x51 Structure Structure
ECL2 180 I 45.52x52 Structure Structure
ECL2 181 Q - Structure Structure
ECL2 182 F - Structure Structure
ECL2 183 L - Structure Structure
ECL2 184 S - Structure Structure
TM5 185 Q 5.35x36 Structure AF2
TM5 186 P 5.36x37 Structure Structure
TM5 187 I 5.37x38 Structure Structure
TM5 188 I 5.38x39 Structure Structure
TM5 189 T 5.39x40 Structure Structure
TM5 190 F 5.40x41 Structure Structure
TM5 191 G 5.41x42 Structure Structure
TM5 192 T 5.42x43 Structure Structure
TM5 193 A 5.43x44 Structure Structure
TM5 194 M 5.44x45 Structure AF2
TM5 195 A 5.45x46 Structure Structure
TM5 196 A 5.46x461 Structure Structure
TM5 197 F 5.47x47 Structure Structure
TM5 198 Y 5.48x48 Structure Structure
TM5 199 L 5.49x49 Structure Structure
TM5 200 P 5.50x50 Structure Structure
TM5 201 V 5.51x51 Structure Structure
TM5 202 T 5.52x52 Structure Structure
TM5 203 V 5.53x53 Structure Structure
TM5 204 M 5.54x54 Structure Structure
TM5 205 C 5.55x55 Structure Structure
TM5 206 T 5.56x56 Structure Structure
TM5 207 L 5.57x57 Structure Structure
TM5 208 Y 5.58x58 Structure Structure
TM5 209 W 5.59x59 Structure Structure
TM5 210 R 5.60x60 Structure Structure
TM5 211 I 5.61x61 Structure Structure
TM5 212 Y 5.62x62 Structure Structure
TM5 213 R 5.63x63 Structure Structure
TM5 214 E 5.64x64 Structure Structure
TM5 215 T 5.65x65 Structure Structure
TM5 216 E 5.66x66 Structure Structure
TM5 217 N 5.67x67 Structure Structure
TM5 218 R 5.68x68 Structure Structure
TM5 219 A 5.69x69 Structure Structure
TM5 220 R 5.70x70 Structure Structure
TM5 221 E 5.71x71 Structure Structure
TM5 222 L 5.72x72 Structure Structure
TM5 223 A 5.73x73 Structure Structure
TM5 224 A 5.74x74 Structure Structure
TM5 225 L 5.75x75 Structure Structure
ICL3 226 Q - Structure Structure
ICL3 227 G - Structure Structure
ICL3 228 S - AF2 AF2
ICL3 229 E - AF2 AF2
ICL3 230 T - AF2 AF2
ICL3 231 P - AF2 AF2
ICL3 232 G - AF2 AF2
ICL3 347 E - AF2 AF2
ICL3 348 Q - AF2 AF2
ICL3 349 L - AF2 AF2
ICL3 350 A - AF2 AF2
ICL3 351 K - AF2 AF2
ICL3 352 R - AF2 AF2
ICL3 353 K - AF2 AF2
TM6 354 T 6.24x24 AF2 AF2
TM6 355 F 6.25x25 AF2 AF2
TM6 356 S 6.26x26 AF2 AF2
TM6 357 L 6.27x27 AF2 AF2
TM6 358 V 6.28x28 AF2 AF2
TM6 359 K 6.29x29 AF2 AF2
TM6 360 E 6.30x30 Structure Structure
TM6 361 K 6.31x31 Structure Structure
TM6 362 K 6.32x32 Structure Structure
TM6 363 A 6.33x33 Structure Structure
TM6 364 A 6.34x34 Structure Structure
TM6 365 R 6.35x35 Structure Structure
TM6 366 T 6.36x36 Structure Structure
TM6 367 L 6.37x37 Structure Structure
TM6 368 S 6.38x38 Structure Structure
TM6 369 A 6.39x39 Structure Structure
TM6 370 I 6.40x40 Structure Structure
TM6 371 L 6.41x41 Structure Structure
TM6 372 L 6.42x42 Structure Structure
TM6 373 A 6.43x43 Structure Structure
TM6 374 F 6.44x44 Structure Structure
TM6 375 I 6.45x45 Structure Structure
TM6 376 L 6.46x46 Structure Structure
TM6 377 T 6.47x47 Structure Structure
TM6 378 W 6.48x48 Structure Structure
TM6 379 T 6.49x49 Structure Structure
TM6 380 P 6.50x50 Structure Structure
TM6 381 Y 6.51x51 Structure Structure
TM6 382 N 6.52x52 Structure Structure
TM6 383 I 6.53x53 Structure Structure
TM6 384 M 6.54x54 Structure Structure
TM6 385 V 6.55x55 Structure Structure
TM6 386 L 6.56x56 Structure Structure
TM6 387 V 6.57x57 Structure Structure
TM6 388 S 6.58x58 Structure Structure
TM6 389 T 6.59x59 Structure Structure
TM6 390 F 6.60x60 Structure Structure
TM6 391 C 6.61x61 Structure Structure
ECL3 392 K - Structure Structure
ECL3 393 D - Structure Structure
ECL3 394 C - Structure Structure
ECL3 395 V - Structure Structure
TM7 396 P 7.31x30 Structure Structure
TM7 397 E 7.32x31 Structure Structure
TM7 398 T 7.33x32 Structure Structure
TM7 399 L 7.34x33 Structure Structure
TM7 400 W 7.35x34 Structure Structure
TM7 401 E 7.36x35 Structure AF2
TM7 402 L 7.37x36 Structure Structure
TM7 403 G 7.38x37 Structure Structure
TM7 404 Y 7.39x38 Structure Structure
TM7 405 W 7.40x39 Structure Structure
TM7 406 L 7.41x40 Structure Structure
TM7 407 C 7.42x41 Structure Structure
TM7 408 Y 7.43x42 Structure Structure
TM7 409 V 7.44x43 Structure Structure
TM7 410 N 7.45x45 Structure Structure
TM7 411 S 7.46x46 Structure Structure
TM7 412 T 7.47x47 Structure Structure
TM7 413 I 7.48x48 Structure Structure
TM7 414 N 7.49x49 Structure Structure
TM7 415 P 7.50x50 Structure Structure
TM7 416 M 7.51x51 Structure Structure
TM7 417 C 7.52x52 Structure Structure
TM7 418 Y 7.53x53 Structure Structure
TM7 419 A 7.54x54 Structure Structure
TM7 420 L 7.55x55 Structure Structure
TM7 421 C 7.56x56 Structure Structure
H8 422 N 8.47x47 Structure Structure
H8 423 K 8.48x48 Structure Structure
H8 424 A 8.49x49 Structure Structure
H8 425 F 8.50x50 Structure Structure
H8 426 R 8.51x51 Structure Structure
H8 427 D 8.52x52 Structure AF2
H8 428 T 8.53x53 Structure Structure
H8 429 F 8.54x54 Structure Structure
H8 430 R 8.55x55 Structure AF2
H8 431 L 8.56x56 Structure Structure
H8 432 L 8.57x57 Structure Structure
H8 433 L 8.58x58 Structure Structure
H8 434 L 8.59x59 Structure AF2
H8 435 C 8.60x60 Structure Structure
C-term 436 R - Structure Structure
C-term 437 W - Structure Structure
C-term 438 D - Structure AF2
C-term 439 K - Structure AF2
C-term 440 R - Structure AF2
C-term 441 R - Structure AF2
C-term 442 W - Structure Structure
C-term 443 R - Structure AF2
C-term 444 K - Structure AF2
C-term 445 I - Structure AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 131 34x51 G.H5 V 344 G.H5.11
Hydrophobic TM5 I 211 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 366 6x36 G.H5 N 357 G.H5.24
Hydrophobic ICL2 P 130 34x50 G.H5 L 349 G.H5.16
Hydrophobic ICL3 G 227 - G.S6 F 328 G.S6.05
Van-der-waals ICL3 G 227 - G.S6 F 328 G.S6.05
Polar ICL2 A 135 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 A 135 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic TM4 R 140 4x40 G.HN R 34 G.HN.52
Van-der-waals TM4 R 140 4x40 G.HN R 34 G.HN.52
Polar ICL3 E 229 - G.H4 E 307 G.H4.09
Hydrophobic ICL3 E 229 - G.H4 E 307 G.H4.09
Van-der-waals ICL3 E 229 - G.H4 E 307 G.H4.09
Polar TM6 E 360 6x30 G.H5 V 359 G.H5.26
Van-der-waals TM6 E 360 6x30 G.H5 V 359 G.H5.26
Hydrophobic TM6 A 363 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL3 Q 226 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 Q 226 - G.h4s6 I 323 G.h4s6.20
Ionic ICL3 E 229 - G.H4 R 306 G.H4.08
Polar H8 N 422 8x47 G.H5 E 355 G.H5.22
Hydrophobic H8 N 422 8x47 G.H5 E 355 G.H5.22
Van-der-waals H8 N 422 8x47 G.H5 E 355 G.H5.22
Polar TM2 N 60 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 60 2x39 G.H5 E 355 G.H5.22
Hydrophobic TM5 L 222 5x72 G.S6 Y 325 G.S6.02
Hydrophobic ICL3 S 228 - G.H4 L 310 G.H4.12
Hydrophobic ICL2 L 131 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 131 34x51 G.H5 F 341 G.H5.08
Polar TM6 K 359 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 359 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 359 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM6 L 367 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM3 V 127 3x54 G.H5 Y 356 G.H5.23
Polar TM4 T 138 4x38 G.HN R 34 G.HN.52
Hydrophobic TM4 T 138 4x38 G.HN R 34 G.HN.52
Van-der-waals TM4 T 138 4x38 G.HN R 34 G.HN.52
Hydrophobic ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 V 127 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 353 G.H5.20
Polar TM5 T 215 5x65 G.H5 L 358 G.H5.25
Hydrophobic TM5 T 215 5x65 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 131 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Polar ICL2 R 134 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 134 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 T 366 6x36 G.H5 L 358 G.H5.25
Polar TM6 K 359 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 K 359 6x29 G.H5 Q 350 G.H5.17
Polar TM5 R 218 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 218 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 R 218 5x68 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 P 130 34x50 G.H5 I 348 G.H5.15
Polar TM7 C 421 7x56 G.H5 Y 356 G.H5.23
Hydrophobic TM7 C 421 7x56 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 G 227 - G.S6 S 326 G.S6.03
Van-der-waals TM7 C 421 7x56 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 131 34x51 G.H5 K 345 G.H5.12
Polar TM3 S 126 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 S 126 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL3 S 228 - G.H4 E 307 G.H4.09
Polar ICL3 Q 348 - G.H4 K 311 G.H4.13
Hydrophobic ICL3 Q 348 - G.H4 K 311 G.H4.13
Van-der-waals ICL3 Q 348 - G.H4 K 311 G.H4.13
Hydrophobic ICL3 T 230 - G.H4 A 304 G.H4.06
Hydrophobic ICL2 A 135 34x55 G.S3 I 199 G.S3.01
Van-der-waals ICL2 A 135 34x55 G.S3 I 199 G.S3.01
Polar ICL3 Q 226 - G.S6 S 326 G.S6.03
Hydrophobic ICL3 Q 226 - G.S6 S 326 G.S6.03
Hydrophobic TM5 R 218 5x68 G.H5 L 353 G.H5.20
Van-der-waals TM5 R 218 5x68 G.H5 L 353 G.H5.20
Polar ICL3 T 230 - G.H4 E 307 G.H4.09
Hydrophobic ICL3 T 230 - G.H4 E 307 G.H4.09
Van-der-waals ICL3 T 230 - G.H4 E 307 G.H4.09
Polar TM5 L 225 5x75 G.S6 S 326 G.S6.03
Van-der-waals TM5 L 225 5x75 G.S6 S 326 G.S6.03
Polar ICL2 R 137 34x57 G.hns1 R 37 G.hns1.02
Polar TM6 K 362 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 362 6x32 G.H5 N 357 G.H5.24
Ionic TM5 R 218 5x68 G.H5 D 346 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 346 G.H5.13
Hydrophobic C-term I 445 - G.H3 P 262 G.H3.16
Hydrophobic TM5 T 215 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM6 K 362 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM3 V 127 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 349 G.H5.16
Polar ICL3 E 229 - G.H4 Q 303 G.H4.05
Van-der-waals ICL3 E 229 - G.H4 Q 303 G.H4.05
Hydrophobic ICL2 R 134 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 134 34x54 G.S1 L 40 G.S1.02
Hydrophobic ICL2 A 135 34x55 G.hns1 R 38 G.hns1.03
Aromatic TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Polar TM3 D 122 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 222 5x72 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM5 L 225 5x75 G.H5 D 346 G.H5.13
Van-der-waals TM5 L 225 5x75 G.H5 D 346 G.H5.13
Polar TM7 C 421 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 C 421 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 C 421 7x56 G.H5 N 357 G.H5.24
Hydrophobic ICL3 G 227 - G.H4 L 310 G.H4.12
Hydrophobic ICL3 Q 348 - G.H4 V 314 G.H4.16
Van-der-waals ICL3 Q 348 - G.H4 V 314 G.H4.16
Hydrophobic TM5 L 225 5x75 G.H5 F 339 G.H5.06
Hydrophobic ICL2 R 134 34x54 G.H5 I 348 G.H5.15
Hydrophobic TM5 L 225 5x75 G.S6 Y 325 G.S6.02
Van-der-waals TM5 L 225 5x75 G.S6 Y 325 G.S6.02
Hydrophobic ICL2 L 131 34x51 G.S3 I 199 G.S3.01
Hydrophobic TM5 L 225 5x75 G.H5 A 342 G.H5.09
Polar TM3 S 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM5 R 218 5x68 G.H5 L 349 G.H5.16