M1 receptor - G11

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6OIJ

RESOLUTION

3.3 Å

REFERENCE

10.1126/SCIENCE.AAW5188

PUBLICATION DATE

May 8, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

iperoxo - Agonist pubchem gtoplig chembl_ligand

ENDOGENOUS LIGANDS

acetylcholine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 225 5x75 G.H5 A 342 G.H5.09
Ionic TM5 R 218 5x68 G.H5 D 346 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM6 A 363 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 A 135 34x55 G.S3 I 199 G.S3.01
Van-der-waals ICL2 A 135 34x55 G.S3 I 199 G.S3.01
Aromatic TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 211 5x61 G.H5 L 358 G.H5.25
Hydrophobic ICL2 R 134 34x54 G.H5 I 348 G.H5.15
Hydrophobic ICL2 L 131 34x51 G.S1 L 40 G.S1.02
Hydrophobic ICL3 G 227 - G.H4 L 310 G.H4.12
Hydrophobic ICL3 G 227 - G.S6 F 328 G.S6.05
Van-der-waals TM5 L 225 5x75 G.S6 S 326 G.S6.03
Hydrophobic TM5 T 215 5x65 G.H5 L 353 G.H5.20
Polar TM2 N 60 2x39 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 60 2x39 G.H5 E 355 G.H5.22
Hydrophobic ICL2 P 130 34x50 G.H5 I 348 G.H5.15
Polar ICL2 R 137 34x57 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 T 366 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM5 R 218 5x68 G.H5 L 353 G.H5.20
Van-der-waals TM5 R 218 5x68 G.H5 L 353 G.H5.20
Hydrophobic ICL3 Q 226 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 Q 226 - G.h4s6 I 323 G.h4s6.20
Hydrophobic ICL2 L 131 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 131 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM6 T 366 6x36 G.H5 N 357 G.H5.24
Hydrophobic ICL3 Q 226 - G.S6 Y 325 G.S6.02
Polar TM3 S 126 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 S 126 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 V 127 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM3 V 127 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 R 134 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 R 134 34x54 G.S1 L 40 G.S1.02
Hydrophobic TM4 P 139 4x39 G.HN E 28 G.HN.52
Hydrophobic TM5 L 222 5x72 G.h4s6 I 323 G.h4s6.20
Polar TM6 K 362 6x32 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 362 6x32 G.H5 N 357 G.H5.24
Polar TM7 C 421 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 C 421 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 C 421 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM5 L 222 5x72 G.S6 Y 325 G.S6.02
Polar TM3 D 122 3x49 G.H5 Y 356 G.H5.23
Polar H8 N 422 8x47 G.H5 E 355 G.H5.22
Hydrophobic H8 N 422 8x47 G.H5 E 355 G.H5.22
Van-der-waals H8 N 422 8x47 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 131 34x51 G.H5 V 344 G.H5.11
Hydrophobic ICL2 P 130 34x50 G.H5 K 345 G.H5.12
Van-der-waals TM7 C 421 7x56 G.H5 E 355 G.H5.22
Hydrophobic ICL2 L 131 34x51 G.S3 I 199 G.S3.01
Polar ICL2 A 135 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 A 135 34x55 G.hns1 R 37 G.hns1.02
Polar TM3 S 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 P 130 34x50 G.H5 L 349 G.H5.16
Polar TM5 R 218 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM5 R 218 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 R 218 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM5 L 225 5x75 G.H5 F 339 G.H5.06
Hydrophobic TM5 R 218 5x68 G.H5 L 349 G.H5.16
Polar ICL2 R 134 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 134 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 L 367 6x37 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 131 34x51 G.H5 K 345 G.H5.12
Polar TM5 T 215 5x65 G.H5 L 358 G.H5.25
Hydrophobic TM5 T 215 5x65 G.H5 L 358 G.H5.25
Hydrophobic ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 V 127 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 349 G.H5.16
Polar TM7 C 421 7x56 G.H5 Y 356 G.H5.23
Hydrophobic TM7 C 421 7x56 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 225 5x75 G.S6 Y 325 G.S6.02
Hydrophobic TM5 L 225 5x75 G.H5 D 346 G.H5.13
Van-der-waals TM5 L 225 5x75 G.H5 D 346 G.H5.13
Hydrophobic ICL2 A 135 34x55 G.hns1 R 38 G.hns1.03