Y1 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

July 31, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

neuropeptide Y, peptide YY, pancreatic polypeptide



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 R 237 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 237 5x64 G.H5 I 345 G.H5.16
Polar TM3 L 141 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 I 142 3x54 G.H5 N 348 G.H5.19
Polar TM6 R 254 6x26 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM3 R 138 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 E 257 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 E 257 6x29 G.H5 F 355 G.H5.26
Polar TM6 R 260 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 141 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 L 141 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM4 R 153 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 153 4x40 G.HN R 24 G.HN.48
Hydrophobic ICL2 P 145 - G.H5 I 344 G.H5.15
Hydrophobic TM6 M 264 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 R 146 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 146 - G.S3 L 195 G.S3.01
Van-der-waals ICL3 D 246 - G.H5 D 342 G.H5.13
Ionic TM4 R 153 4x40 G.HN E 28 G.HN.52
Polar TM4 R 153 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 R 153 4x40 G.HN E 28 G.HN.52
Hydrophobic TM3 I 142 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 349 G.H5.20
Hydrophobic H8 K 325 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 K 325 8x48 G.H5 F 355 G.H5.26
Hydrophobic ICL2 R 146 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 R 146 - G.H5 F 337 G.H5.08
Hydrophobic TM3 I 142 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 I 345 G.H5.16
Polar ICL2 R 146 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 R 146 - G.H5 T 341 G.H5.12
Hydrophobic H8 N 324 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 N 324 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 I 142 3x54 G.H5 C 352 G.H5.23
Polar TM4 N 151 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 N 151 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 P 145 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 145 - G.H5 I 345 G.H5.16
Hydrophobic TM5 L 238 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 238 5x65 G.H5 L 349 G.H5.20
Polar TM3 R 138 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 I 261 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 261 6x33 G.H5 L 354 G.H5.25
Aromatic TM6 R 260 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 260 6x32 G.H5 F 355 G.H5.26
Polar TM6 Y 253 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 Y 253 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 Y 253 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 I 261 6x33 G.H5 F 355 G.H5.26