CB1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IKG

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

June 5, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

19 interactions (Click to see)

LIGANDS

3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole - Agonist pubchem

PHYSIOLOGICAL LIGANDS

anandamide, 2-arachidonoylglycerol



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 K 225 - G.H5 D 350 G.H5.22
Polar ICL2 K 225 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 225 - G.H5 D 350 G.H5.22
Polar TM2 S 152 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 H 304 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 M 308 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 M 308 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 221 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 221 - G.H5 I 344 G.H5.16
Aromatic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 340 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 M 337 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 218 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 218 3x54 G.H5 L 348 G.H5.20
Polar TM3 S 217 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 222 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 222 - G.H5 I 343 G.H5.15
Hydrophobic TM6 L 341 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 341 6x33 G.H5 L 353 G.H5.25
Polar ICL4 S 401 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 S 401 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 S 401 - G.H5 G 352 G.H5.24
Hydrophobic TM3 S 217 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 222 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 R 226 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 226 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 T 313 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 T 313 - G.H5 F 334 G.H5.06
Hydrophobic TM5 R 311 5x75 G.H5 F 334 G.H5.06
Hydrophobic TM6 L 341 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 345 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 214 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 214 3x50 G.H5 C 351 G.H5.23
Ionic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Polar TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 311 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 311 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 H 304 5x68 G.H5 D 341 G.H5.13
Polar ICL2 P 221 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 221 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 224 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 224 - G.H5 N 347 G.H5.19
Hydrophobic TM3 R 214 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 337 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 M 337 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 341 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 341 6x33 G.H5 F 354 G.H5.26
Ionic TM2 R 150 2x37 G.H5 D 350 G.H5.22
Polar TM2 R 150 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 150 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 150 2x37 G.H5 D 350 G.H5.22